318161:SDEN RS15075
gene id: 318161:SDEN_RS15075
uniprot id: Q12K47
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

318161:SDEN RS14085
gene id: 318161:SDEN_RS14085
uniprot id: Q12KN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS05715
gene id: 318161:SDEN_RS05715
uniprot id: Q12Q91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase chaperone family.
messages: Cell inner membrane
messages: May be involved in the folding of the extracellular lipase during its passage through the periplasm.

318161:SDEN RS13050
gene id: 318161:SDEN_RS13050
uniprot id: Q12L79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CysZ family.
messages: Cell inner membrane
messages: High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway.

318161:SDEN RS02465
gene id: 318161:SDEN_RS02465
uniprot id: Q12S16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS19185
gene id: 318161:SDEN_RS19185
uniprot id: Q12HW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

318161:SDEN RS03905
gene id: 318161:SDEN_RS03905
uniprot id: Q12R83
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

318161:SDEN RS10990
gene id: 318161:SDEN_RS10990
uniprot id: Q12MD5
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.

318161:SDEN RS04210
gene id: 318161:SDEN_RS04210
uniprot id: Q12R24
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

318161:SDEN RS00150
gene id: 318161:SDEN_RS00150
uniprot id: Q12T99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

318161:SDEN RS19555
gene id: 318161:SDEN_RS19555
uniprot id: Q12HP4
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS10155
gene id: 318161:SDEN_RS10155
uniprot id: Q12MU7
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

318161:SDEN RS05955
gene id: 318161:SDEN_RS05955
uniprot id: Q12Q44
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

318161:SDEN RS18900
gene id: 318161:SDEN_RS18900
uniprot id: Q12I14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

318161:SDEN RS09730
gene id: 318161:SDEN_RS09730
uniprot id: Q12N30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

318161:SDEN RS17620
gene id: 318161:SDEN_RS17620
uniprot id: Q12IQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapD family.
messages: Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
messages: Cytoplasm
messages: Interacts with FtsZ.

318161:SDEN RS06245
gene id: 318161:SDEN_RS06245
uniprot id: Q12PY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

318161:SDEN RS10425
gene id: 318161:SDEN_RS10425
uniprot id: Q12MP3
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

318161:SDEN RS15880
gene id: 318161:SDEN_RS15880
uniprot id: Q12JP6
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

318161:SDEN RS02815
gene id: 318161:SDEN_RS02815
uniprot id: Q12RU7
names: Similarity
messages: Belongs to the PhoH family.

318161:SDEN RS16930
gene id: 318161:SDEN_RS16930
uniprot id: Q12J44
names: Similarity
messages: Belongs to the glycosyl hydrolase 24 family.

318161:SDEN RS07670
gene id: 318161:SDEN_RS07670
uniprot id: Q12P76
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

318161:SDEN RS06150
gene id: 318161:SDEN_RS06150
uniprot id: Q12Q07
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

318161:SDEN RS05930
gene id: 318161:SDEN_RS05930
uniprot id: Q12Q49
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

318161:SDEN RS19055
gene id: 318161:SDEN_RS19055
uniprot id: Q12HY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

318161:SDEN RS10650
gene id: 318161:SDEN_RS10650
uniprot id: Q12MK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

318161:SDEN RS01715
gene id: 318161:SDEN_RS01715
uniprot id: Q12SF7
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

318161:SDEN RS04620
gene id: 318161:SDEN_RS04620
uniprot id: Q12QV1
names: Similarity
messages: Belongs to the peptidase M24B family.

318161:SDEN RS14625
gene id: 318161:SDEN_RS14625
uniprot id: Q12KD2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters for at least IspG.

318161:SDEN RS18720
gene id: 318161:SDEN_RS18720
uniprot id: Q12I50
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

318161:SDEN RS02030
gene id: 318161:SDEN_RS02030
uniprot id: Q12S98
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS06960
gene id: 318161:SDEN_RS06960
uniprot id: Q12PK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

318161:SDEN RS08110
gene id: 318161:SDEN_RS08110
uniprot id: Q12NY9
names: Activity Regulation
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

318161:SDEN RS12830
gene id: 318161:SDEN_RS12830
uniprot id: Q12LC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0283 family.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS10355
gene id: 318161:SDEN_RS10355
uniprot id: Q12MQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SeqA family.
messages: Cytoplasm
messages: Homodimer. Polymerizes to form helical filaments.
messages: Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.

318161:SDEN RS12035
gene id: 318161:SDEN_RS12035
uniprot id: Q12LS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS14360
gene id: 318161:SDEN_RS14360
uniprot id: Q12KI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

318161:SDEN RS04910
gene id: 318161:SDEN_RS04910
uniprot id: Q12QP3
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS00865
gene id: 318161:SDEN_RS00865
uniprot id: Q12SX0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

318161:SDEN RS13935
gene id: 318161:SDEN_RS13935
uniprot id: Q12KR7
names: Similarity
messages: Belongs to the GSP E family.

318161:SDEN RS17365
gene id: 318161:SDEN_RS17365
uniprot id: Q12IV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

318161:SDEN RS00080
gene id: 318161:SDEN_RS00080
uniprot id: Q12TB3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Splits dipeptides with a prolyl residue in the C-terminal position.

318161:SDEN RS00220
gene id: 318161:SDEN_RS00220
uniprot id: Q12T88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Membrane

318161:SDEN RS07505
gene id: 318161:SDEN_RS07505
uniprot id: Q12PA5
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS00435
gene id: 318161:SDEN_RS00435
uniprot id: Q12T45
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
messages: Cytoplasm

318161:SDEN RS06460
gene id: 318161:SDEN_RS06460
uniprot id: Q12PV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

318161:SDEN RS06215
gene id: 318161:SDEN_RS06215
uniprot id: Q12PZ4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

318161:SDEN RS11935
gene id: 318161:SDEN_RS11935
uniprot id: Q12LU5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

318161:SDEN RS14670
gene id: 318161:SDEN_RS14670
uniprot id: Q12KC3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane.
messages: Belongs to the Lpp family.
messages: Cell outer membrane
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: cell wall

318161:SDEN RS17925
gene id: 318161:SDEN_RS17925
uniprot id: Q12IK4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS14555
gene id: 318161:SDEN_RS14555
uniprot id: Q12KE6
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
messages: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.

318161:SDEN RS10270
gene id: 318161:SDEN_RS10270
uniprot id: Q12MS4
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS05980
gene id: 318161:SDEN_RS05980
uniprot id: Q12Q39
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

318161:SDEN RS00145
gene id: 318161:SDEN_RS00145
uniprot id: Q12TA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family. TsaC subfamily.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.

318161:SDEN RS14990
gene id: 318161:SDEN_RS14990
uniprot id: Q12K65
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homodimer.
messages: Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.
messages: The transmembrane domain is a dimerization domain.

318161:SDEN RS01230
gene id: 318161:SDEN_RS01230
uniprot id: Q12SP7
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

318161:SDEN RS11840
gene id: 318161:SDEN_RS11840
uniprot id: Q12LW4
names: Similarity
messages: Belongs to the UPF0502 family.

318161:SDEN RS10660
gene id: 318161:SDEN_RS10660
uniprot id: Q12MK0
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

318161:SDEN RS03090
gene id: 318161:SDEN_RS03090
uniprot id: Q12RP6
names: Similarity
names: Subunit
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family. SbnA subfamily.
messages: Homodimer.

318161:SDEN RS18215
gene id: 318161:SDEN_RS18215
uniprot id: Q12IE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

318161:SDEN RS08510
gene id: 318161:SDEN_RS08510
uniprot id: Q12NR0
names: Similarity
messages: Belongs to the UPF0260 family.

318161:SDEN RS04335
gene id: 318161:SDEN_RS04335
uniprot id: Q12R05
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

318161:SDEN RS10915
gene id: 318161:SDEN_RS10915
uniprot id: Q12ME9
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

318161:SDEN RS00870
gene id: 318161:SDEN_RS00870
uniprot id: Q12SW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

318161:SDEN RS01465
gene id: 318161:SDEN_RS01465
uniprot id: Q12SK8
names: Similarity
messages: Belongs to the UPF0102 family.

318161:SDEN RS18235
gene id: 318161:SDEN_RS18235
uniprot id: Q12IE3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

318161:SDEN RS05125
gene id: 318161:SDEN_RS05125
uniprot id: Q12QK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

318161:SDEN RS11320
gene id: 318161:SDEN_RS11320
uniprot id: Q12M68
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

318161:SDEN RS14500
gene id: 318161:SDEN_RS14500
uniprot id: Q12KF7
names: Similarity
messages: Belongs to the glutamate synthase family.

318161:SDEN RS07345
gene id: 318161:SDEN_RS07345
uniprot id: Q12PD7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

318161:SDEN RS07080
gene id: 318161:SDEN_RS07080
uniprot id: Q12PH9
names: Similarity
names: Subunit
messages: Belongs to the threonine aldolase family.
messages: Homotetramer.

318161:SDEN RS02675
gene id: 318161:SDEN_RS02675
uniprot id: Q12RX5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

318161:SDEN RS03865
gene id: 318161:SDEN_RS03865
uniprot id: Q12R91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).

318161:SDEN RS11260
gene id: 318161:SDEN_RS11260
uniprot id: Q12M81
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

318161:SDEN RS08520
gene id: 318161:SDEN_RS08520
uniprot id: Q12NQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
messages: Cell inner membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

318161:SDEN RS01775
gene id: 318161:SDEN_RS01775
uniprot id: Q12SE5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

318161:SDEN RS18965
gene id: 318161:SDEN_RS18965
uniprot id: Q12I01
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

318161:SDEN RS00530
gene id: 318161:SDEN_RS00530
uniprot id: Q12T27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

318161:SDEN RS06210
gene id: 318161:SDEN_RS06210
uniprot id: Q12PZ5
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

318161:SDEN RS11110
gene id: 318161:SDEN_RS11110
uniprot id: Q12MB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO8N (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in the Shewanella genus.
messages: Belongs to the KdsB family.
messages: Cytoplasm

318161:SDEN RS04990
gene id: 318161:SDEN_RS04990
uniprot id: Q12QM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

318161:SDEN RS11345
gene id: 318161:SDEN_RS11345
uniprot id: Q12M64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

318161:SDEN RS01335
gene id: 318161:SDEN_RS01335
uniprot id: Q12SN4
names: Similarity
messages: Belongs to the CinA family.

318161:SDEN RS09430
gene id: 318161:SDEN_RS09430
uniprot id: Q12N83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

318161:SDEN RS11305
gene id: 318161:SDEN_RS11305
uniprot id: Q12M72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS04490
gene id: 318161:SDEN_RS04490
uniprot id: Q12QX7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

318161:SDEN RS14165
gene id: 318161:SDEN_RS14165
uniprot id: Q12KM3
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

318161:SDEN RS03250
gene id: 318161:SDEN_RS03250
uniprot id: Q12RL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS13735
gene id: 318161:SDEN_RS13735
uniprot id: Q12KV7
names: Cofactor
names: Similarity
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.

318161:SDEN RS14370
gene id: 318161:SDEN_RS14370
uniprot id: Q12KI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

318161:SDEN RS04345
gene id: 318161:SDEN_RS04345
uniprot id: Q12R03
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

318161:SDEN RS14880
gene id: 318161:SDEN_RS14880
uniprot id: Q12K85
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

318161:SDEN RS17715
gene id: 318161:SDEN_RS17715
uniprot id: Q12IP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

318161:SDEN RS15940
gene id: 318161:SDEN_RS15940
uniprot id: Q12JN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS08645
gene id: 318161:SDEN_RS08645
uniprot id: Q12NN4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

318161:SDEN RS14610
gene id: 318161:SDEN_RS14610
uniprot id: Q12KD5
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

318161:SDEN RS14905
gene id: 318161:SDEN_RS14905
uniprot id: Q12K82
names: Subcellular Location Annotation
messages: Cytoplasm

318161:SDEN RS04775
gene id: 318161:SDEN_RS04775
uniprot id: Q12QS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolB family.
messages: Cell outer membrane
messages: Monomer.
messages: Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.

318161:SDEN RS10215
gene id: 318161:SDEN_RS10215
uniprot id: Q12MT5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS09990
gene id: 318161:SDEN_RS09990
uniprot id: Q12MX9
names: Similarity
messages: Belongs to the ice-binding protein family.

318161:SDEN RS19495
gene id: 318161:SDEN_RS19495
uniprot id: Q12HQ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

318161:SDEN RS16825
gene id: 318161:SDEN_RS16825
uniprot id: Q12J65
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

318161:SDEN RS13000
gene id: 318161:SDEN_RS13000
uniprot id: Q12L89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

318161:SDEN RS08385
gene id: 318161:SDEN_RS08385
uniprot id: Q12NT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

318161:SDEN RS07330
gene id: 318161:SDEN_RS07330
uniprot id: Q12PE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

318161:SDEN RS08420
gene id: 318161:SDEN_RS08420
uniprot id: Q12NS8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

318161:SDEN RS08155
gene id: 318161:SDEN_RS08155
uniprot id: Q12NY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

318161:SDEN RS01140
gene id: 318161:SDEN_RS01140
uniprot id: Q12SR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

318161:SDEN RS05055
gene id: 318161:SDEN_RS05055
uniprot id: Q12QL7
names: Function
names: Similarity
messages: Belongs to the CsgG family.
messages: May be involved in the biogenesis of curli organelles.

318161:SDEN RS02355
gene id: 318161:SDEN_RS02355
uniprot id: Q12S38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

318161:SDEN RS10165
gene id: 318161:SDEN_RS10165
uniprot id: Q12MU5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

318161:SDEN RS18805
gene id: 318161:SDEN_RS18805
uniprot id: Q12I33
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS10935
gene id: 318161:SDEN_RS10935
uniprot id: Q12ME5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

318161:SDEN RS14635
gene id: 318161:SDEN_RS14635
uniprot id: Q12KD0
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS06180
gene id: 318161:SDEN_RS06180
uniprot id: Q12Q01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

318161:SDEN RS03650
gene id: 318161:SDEN_RS03650
uniprot id: Q12RD4
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

318161:SDEN RS05705
gene id: 318161:SDEN_RS05705
uniprot id: Q12Q93
names: Similarity
messages: Belongs to the peptidase S11 family.

318161:SDEN RS16025
gene id: 318161:SDEN_RS16025
uniprot id: Q12JL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

318161:SDEN RS12785
gene id: 318161:SDEN_RS12785
uniprot id: Q12LD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

318161:SDEN RS12615
gene id: 318161:SDEN_RS12615
uniprot id: Q12LG4
names: Similarity
messages: Belongs to the UPF0319 family.

318161:SDEN RS17740
gene id: 318161:SDEN_RS17740
uniprot id: Q12IN5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS09910
gene id: 318161:SDEN_RS09910
uniprot id: Q12MZ4
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

318161:SDEN RS11870
gene id: 318161:SDEN_RS11870
uniprot id: Q12LV8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion.
messages: Homodimer.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

318161:SDEN RS01355
gene id: 318161:SDEN_RS01355
uniprot id: Q12SN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

318161:SDEN RS12930
gene id: 318161:SDEN_RS12930
uniprot id: Q12LA0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

318161:SDEN RS08650
gene id: 318161:SDEN_RS08650
uniprot id: Q12NN3
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

318161:SDEN RS07070
gene id: 318161:SDEN_RS07070
uniprot id: Q12PI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
messages: Membrane

318161:SDEN RS05115
gene id: 318161:SDEN_RS05115
uniprot id: Q12QK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

318161:SDEN RS17370
gene id: 318161:SDEN_RS17370
uniprot id: Q12IV6
names: Similarity
messages: Belongs to the GSP E family.

318161:SDEN RS01210
gene id: 318161:SDEN_RS01210
uniprot id: Q12SQ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

318161:SDEN RS13255
gene id: 318161:SDEN_RS13255
uniprot id: Q12L53
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS00985
gene id: 318161:SDEN_RS00985
uniprot id: Q12SU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

318161:SDEN RS14385
gene id: 318161:SDEN_RS14385
uniprot id: Q12KH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

318161:SDEN RS03635
gene id: 318161:SDEN_RS03635
uniprot id: Q12RD7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cell membrane
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS11050
gene id: 318161:SDEN_RS11050
uniprot id: Q12MC2
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

318161:SDEN RS08715
gene id: 318161:SDEN_RS08715
uniprot id: Q12NM0
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS16640
gene id: 318161:SDEN_RS16640
uniprot id: Q12J98
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

318161:SDEN RS08620
gene id: 318161:SDEN_RS08620
uniprot id: Q12NN8
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

318161:SDEN RS04840
gene id: 318161:SDEN_RS04840
uniprot id: Q12QQ7
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

318161:SDEN RS10670
gene id: 318161:SDEN_RS10670
uniprot id: Q12MJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.

318161:SDEN RS11425
gene id: 318161:SDEN_RS11425
uniprot id: Q12M47
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

318161:SDEN RS05305
gene id: 318161:SDEN_RS05305
uniprot id: Q12QG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

318161:SDEN RS12725
gene id: 318161:SDEN_RS12725
uniprot id: Q12LE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

318161:SDEN RS00935
gene id: 318161:SDEN_RS00935
uniprot id: Q12SV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

318161:SDEN RS07660
gene id: 318161:SDEN_RS07660
uniprot id: Q12P78
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

318161:SDEN RS02370
gene id: 318161:SDEN_RS02370
uniprot id: Q12S35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. RhlB subfamily.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

318161:SDEN RS09370
gene id: 318161:SDEN_RS09370
uniprot id: Q12N95
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

318161:SDEN RS14890
gene id: 318161:SDEN_RS14890
uniprot id: Q12K83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamD family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

318161:SDEN RS05105
gene id: 318161:SDEN_RS05105
uniprot id: Q12QK7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

318161:SDEN RS05390
gene id: 318161:SDEN_RS05390
uniprot id: Q12QF2
names: Function
names: Subunit
messages: Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second-messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a possible effector protein.
messages: Monomer in both c-di-GMP-bound and free forms.

318161:SDEN RS05595
gene id: 318161:SDEN_RS05595
uniprot id: Q12QB5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutB family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

318161:SDEN RS01770
gene id: 318161:SDEN_RS01770
uniprot id: Q12SE6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS08125
gene id: 318161:SDEN_RS08125
uniprot id: Q12NY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

318161:SDEN RS04150
gene id: 318161:SDEN_RS04150
uniprot id: Q12R34
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS18675
gene id: 318161:SDEN_RS18675
uniprot id: Q12I59
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

318161:SDEN RS15105
gene id: 318161:SDEN_RS15105
uniprot id: Q12K41
names: Similarity
messages: Belongs to the UPF0231 family.

318161:SDEN RS11145
gene id: 318161:SDEN_RS11145
uniprot id: Q12MA4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

318161:SDEN RS04540
gene id: 318161:SDEN_RS04540
uniprot id: Q12QW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

318161:SDEN RS10240
gene id: 318161:SDEN_RS10240
uniprot id: Q12MT0
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

318161:SDEN RS17960
gene id: 318161:SDEN_RS17960
uniprot id: Q12IJ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

318161:SDEN RS08690
gene id: 318161:SDEN_RS08690
uniprot id: Q12NM5
names: Similarity
messages: Belongs to the PrpF family.

318161:SDEN RS03610
gene id: 318161:SDEN_RS03610
uniprot id: Q12RE2
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS04005
gene id: 318161:SDEN_RS04005
uniprot id: Q12R63
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

318161:SDEN RS11125
gene id: 318161:SDEN_RS11125
uniprot id: Q12MA8
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

318161:SDEN RS05215
gene id: 318161:SDEN_RS05215
uniprot id: Q12QI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

318161:SDEN RS02360
gene id: 318161:SDEN_RS02360
uniprot id: Q12S37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.

318161:SDEN RS18905
gene id: 318161:SDEN_RS18905
uniprot id: Q12I13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

318161:SDEN RS02835
gene id: 318161:SDEN_RS02835
uniprot id: Q12RU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm

318161:SDEN RS02690
gene id: 318161:SDEN_RS02690
uniprot id: Q12RX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

318161:SDEN RS04110
gene id: 318161:SDEN_RS04110
uniprot id: Q12R42
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

318161:SDEN RS00065
gene id: 318161:SDEN_RS00065
uniprot id: Q12TB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfur carrier protein TusA family.
messages: Cytoplasm
messages: Sulfur carrier protein which probably makes part of a sulfur-relay system.

318161:SDEN RS01845
gene id: 318161:SDEN_RS01845
uniprot id: Q12SD1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS06565
gene id: 318161:SDEN_RS06565
uniprot id: Q12PT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamB family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

318161:SDEN RS09830
gene id: 318161:SDEN_RS09830
uniprot id: Q12N10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

318161:SDEN RS09530
gene id: 318161:SDEN_RS09530
uniprot id: Q12N64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm

318161:SDEN RS03705
gene id: 318161:SDEN_RS03705
uniprot id: Q12RC3
names: Function
messages: Repressor involved in choline regulation of the bet genes.
messages: Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine.

318161:SDEN RS12310
gene id: 318161:SDEN_RS12310
uniprot id: Q12LM5
names: Similarity
messages: Belongs to the alkaline phosphatase family.

318161:SDEN RS00605
gene id: 318161:SDEN_RS00605
uniprot id: Q12T12
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Monomer.

318161:SDEN RS14240
gene id: 318161:SDEN_RS14240
uniprot id: Q12KK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

318161:SDEN RS12080
gene id: 318161:SDEN_RS12080
uniprot id: Q12LR6
names: Similarity
messages: Belongs to the intimin/invasin family.

318161:SDEN RS17460
gene id: 318161:SDEN_RS17460
uniprot id: Q12IT9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

318161:SDEN RS15975
gene id: 318161:SDEN_RS15975
uniprot id: Q12JM7
names: Similarity
messages: Belongs to the band 7/mec-2 family.

318161:SDEN RS09505
gene id: 318161:SDEN_RS09505
uniprot id: Q12N69
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.

318161:SDEN RS14145
gene id: 318161:SDEN_RS14145
uniprot id: Q12KM7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

318161:SDEN RS07610
gene id: 318161:SDEN_RS07610
uniprot id: Q12P88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PsiE family.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS11080
gene id: 318161:SDEN_RS11080
uniprot id: Q12MB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0312 family. Type 1 subfamily.
messages: Periplasm

318161:SDEN RS19230
gene id: 318161:SDEN_RS19230
uniprot id: Q12HV3
names: Similarity
messages: Belongs to the peptidase S41A family.

318161:SDEN RS09045
gene id: 318161:SDEN_RS09045
uniprot id: Q12NF8
names: Subcellular Location Annotation
messages: Cytoplasm

318161:SDEN RS13895
gene id: 318161:SDEN_RS13895
uniprot id: Q12KS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RfaH family.
messages: Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components.
messages: Interacts with both the nontemplate DNA and the RNA polymerase (RNAP).

318161:SDEN RS06770
gene id: 318161:SDEN_RS06770
uniprot id: Q12PP1
names: Function
names: Similarity
messages: Belongs to the FlgM family.
messages: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

318161:SDEN RS07580
gene id: 318161:SDEN_RS07580
uniprot id: Q12P94
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

318161:SDEN RS18810
gene id: 318161:SDEN_RS18810
uniprot id: Q12I32
names: Function
names: Similarity
messages: Belongs to the peptidase C56 family.
messages: Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate.

318161:SDEN RS13350
gene id: 318161:SDEN_RS13350
uniprot id: Q12L34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

318161:SDEN RS00230
gene id: 318161:SDEN_RS00230
uniprot id: Q12T86
names: Similarity
messages: Belongs to the type III secretion exporter family.

318161:SDEN RS00260
gene id: 318161:SDEN_RS00260
uniprot id: Q12T80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: Periplasm
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

318161:SDEN RS14695
gene id: 318161:SDEN_RS14695
uniprot id: Q12KB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

318161:SDEN RS01005
gene id: 318161:SDEN_RS01005
uniprot id: Q12SU2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

318161:SDEN RS13230
gene id: 318161:SDEN_RS13230
uniprot id: Q12L58
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

318161:SDEN RS14520
gene id: 318161:SDEN_RS14520
uniprot id: Q12KF3
names: Similarity
messages: Belongs to the nitroreductase family.

318161:SDEN RS08025
gene id: 318161:SDEN_RS08025
uniprot id: Q12P05
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.
messages: Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue.

318161:SDEN RS18415
gene id: 318161:SDEN_RS18415
uniprot id: Q12IA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CopD family.
messages: Cell inner membrane
messages: Involved in copper resistance. Appears to be involved in copper uptake.
messages: Membrane

318161:SDEN RS14265
gene id: 318161:SDEN_RS14265
uniprot id: Q12KK3
names: PTM
messages: Binds 1 heme group per subunit.

318161:SDEN RS06955
gene id: 318161:SDEN_RS06955
uniprot id: Q12PK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

318161:SDEN RS06570
gene id: 318161:SDEN_RS06570
uniprot id: Q12PT0
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

318161:SDEN RS03070
gene id: 318161:SDEN_RS03070
uniprot id: Q12RQ0
names: Similarity
messages: Belongs to the IucA/IucC family.

318161:SDEN RS15995
gene id: 318161:SDEN_RS15995
uniprot id: Q12JM3
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

318161:SDEN RS13975
gene id: 318161:SDEN_RS13975
uniprot id: Q12KQ9
names: Function
messages: Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.

318161:SDEN RS12530
gene id: 318161:SDEN_RS12530
uniprot id: Q12LI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

318161:SDEN RS00275
gene id: 318161:SDEN_RS00275
uniprot id: Q12T77
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

318161:SDEN RS11940
gene id: 318161:SDEN_RS11940
uniprot id: Q12LU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase E/G family. RNase E subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per homotetramer.
messages: Cell inner membrane
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.
messages: Cytoplasm
messages: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.

318161:SDEN RS00505
gene id: 318161:SDEN_RS00505
uniprot id: Q12T32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 1618 of 23S rRNA.

318161:SDEN RS13245
gene id: 318161:SDEN_RS13245
uniprot id: Q12L55
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

318161:SDEN RS08480
gene id: 318161:SDEN_RS08480
uniprot id: Q12NR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase D family.
messages: Cytoplasm
messages: Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.

318161:SDEN RS16705
gene id: 318161:SDEN_RS16705
uniprot id: Q12J88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

318161:SDEN RS08940
gene id: 318161:SDEN_RS08940
uniprot id: Q12NH9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

318161:SDEN RS12635
gene id: 318161:SDEN_RS12635
uniprot id: Q12LG0
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

318161:SDEN RS09265
gene id: 318161:SDEN_RS09265
uniprot id: Q12NB3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.

318161:SDEN RS14965
gene id: 318161:SDEN_RS14965
uniprot id: Q12K70
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

318161:SDEN RS12950
gene id: 318161:SDEN_RS12950
uniprot id: Q12L99
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

318161:SDEN RS14450
gene id: 318161:SDEN_RS14450
uniprot id: Q12KG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

318161:SDEN RS01795
gene id: 318161:SDEN_RS01795
uniprot id: Q12SE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

318161:SDEN RS19515
gene id: 318161:SDEN_RS19515
uniprot id: Q12HQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

318161:SDEN RS19765
gene id: 318161:SDEN_RS19765
uniprot id: Q12PL1
names: Function
names: Similarity
messages: Belongs to the FliK family.
messages: Controls the length of the flagellar hook.

318161:SDEN RS06625
gene id: 318161:SDEN_RS06625
uniprot id: Q12PR9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

318161:SDEN RS02645
gene id: 318161:SDEN_RS02645
uniprot id: Q12RY1
names: Similarity
messages: Belongs to the peptidase S1C family.

318161:SDEN RS11815
gene id: 318161:SDEN_RS11815
uniprot id: Q12LW9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.

318161:SDEN RS02780
gene id: 318161:SDEN_RS02780
uniprot id: Q12RV4
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

318161:SDEN RS18240
gene id: 318161:SDEN_RS18240
uniprot id: Q12IE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

318161:SDEN RS06775
gene id: 318161:SDEN_RS06775
uniprot id: Q12PP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgA family.
messages: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
messages: Periplasm

318161:SDEN RS11175
gene id: 318161:SDEN_RS11175
uniprot id: Q12M98
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

318161:SDEN RS15510
gene id: 318161:SDEN_RS15510
uniprot id: Q12JW6
names: Similarity
messages: Belongs to the aspartokinase family.

318161:SDEN RS06450
gene id: 318161:SDEN_RS06450
uniprot id: Q12PV3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

318161:SDEN RS08380
gene id: 318161:SDEN_RS08380
uniprot id: Q12NT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily.
messages: Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A.
messages: Cell inner membrane

318161:SDEN RS19600
gene id: 318161:SDEN_RS19600
uniprot id: Q12HN5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS19520
gene id: 318161:SDEN_RS19520
uniprot id: Q12HQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

318161:SDEN RS03590
gene id: 318161:SDEN_RS03590
uniprot id: Q12RE6
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS17690
gene id: 318161:SDEN_RS17690
uniprot id: Q12IP5
names: Similarity
messages: Belongs to the GARS family.

318161:SDEN RS00890
gene id: 318161:SDEN_RS00890
uniprot id: Q12SW5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

318161:SDEN RS05500
gene id: 318161:SDEN_RS05500
uniprot id: Q12QD2
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family. AstD subfamily.
messages: Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.

318161:SDEN RS07350
gene id: 318161:SDEN_RS07350
uniprot id: Q12PD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

318161:SDEN RS08435
gene id: 318161:SDEN_RS08435
uniprot id: Q12NS5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

318161:SDEN RS18360
gene id: 318161:SDEN_RS18360
uniprot id: Q12IB9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: In the C-terminal section; belongs to the NRP synthetase family.

318161:SDEN RS02590
gene id: 318161:SDEN_RS02590
uniprot id: Q12RZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptC family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptA and the LptBFG transporter complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA.
messages: Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

318161:SDEN RS10520
gene id: 318161:SDEN_RS10520
uniprot id: Q12MM7
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS01460
gene id: 318161:SDEN_RS01460
uniprot id: Q12SK9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Homotetramer.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

318161:SDEN RS00635
gene id: 318161:SDEN_RS00635
uniprot id: Q12T06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

318161:SDEN RS04235
gene id: 318161:SDEN_RS04235
uniprot id: Q12R19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

318161:SDEN RS00310
gene id: 318161:SDEN_RS00310
uniprot id: Q12T70
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

318161:SDEN RS16480
gene id: 318161:SDEN_RS16480
uniprot id: Q12JD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.

318161:SDEN RS14235
gene id: 318161:SDEN_RS14235
uniprot id: Q12KK9
names: Similarity
messages: Belongs to the threonine synthase family.

318161:SDEN RS12155
gene id: 318161:SDEN_RS12155
uniprot id: Q12LQ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrQ family.
messages: Binds 1 FMN per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Cell inner membrane
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Membrane
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.

318161:SDEN RS13835
gene id: 318161:SDEN_RS13835
uniprot id: Q12KT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

318161:SDEN RS01625
gene id: 318161:SDEN_RS01625
uniprot id: Q12SH4
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

318161:SDEN RS15375
gene id: 318161:SDEN_RS15375
uniprot id: Q12JZ3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

318161:SDEN RS13590
gene id: 318161:SDEN_RS13590
uniprot id: Q12KY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

318161:SDEN RS02070
gene id: 318161:SDEN_RS02070
uniprot id: Q12S90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS15785
gene id: 318161:SDEN_RS15785
uniprot id: Q12JR4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

318161:SDEN RS09130
gene id: 318161:SDEN_RS09130
uniprot id: Q12NE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

318161:SDEN RS04770
gene id: 318161:SDEN_RS04770
uniprot id: Q12QS1
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

318161:SDEN RS03225
gene id: 318161:SDEN_RS03225
uniprot id: Q12RM0
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

318161:SDEN RS01755
gene id: 318161:SDEN_RS01755
uniprot id: Q12SE9
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

318161:SDEN RS16570
gene id: 318161:SDEN_RS16570
uniprot id: Q12JB2
names: Similarity
messages: Belongs to the phosphoribulokinase family.

318161:SDEN RS04220
gene id: 318161:SDEN_RS04220
uniprot id: Q12R22
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

318161:SDEN RS09560
gene id: 318161:SDEN_RS09560
uniprot id: Q12N58
names: Similarity
messages: Belongs to the ClpA/ClpB family.

318161:SDEN RS00010
gene id: 318161:SDEN_RS00010
uniprot id: Q12TC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

318161:SDEN RS14705
gene id: 318161:SDEN_RS14705
uniprot id: Q12KB6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

318161:SDEN RS14410
gene id: 318161:SDEN_RS14410
uniprot id: Q12KH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

318161:SDEN RS02080
gene id: 318161:SDEN_RS02080
uniprot id: Q12S88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

318161:SDEN RS04780
gene id: 318161:SDEN_RS04780
uniprot id: Q12QR9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

318161:SDEN RS04880
gene id: 318161:SDEN_RS04880
uniprot id: Q12QP9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

318161:SDEN RS18315
gene id: 318161:SDEN_RS18315
uniprot id: Q12IC8
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS12255
gene id: 318161:SDEN_RS12255
uniprot id: Q12LN2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS14605
gene id: 318161:SDEN_RS14605
uniprot id: Q12KD6
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS04520
gene id: 318161:SDEN_RS04520
uniprot id: Q12QX1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

318161:SDEN RS01890
gene id: 318161:SDEN_RS01890
uniprot id: Q12SC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

318161:SDEN RS03080
gene id: 318161:SDEN_RS03080
uniprot id: Q12RP8
names: Similarity
messages: Belongs to the IucA/IucC family.

318161:SDEN RS09630
gene id: 318161:SDEN_RS09630
uniprot id: Q12N44
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CcoP / FixP family.
messages: Binds 2 heme C groups per subunit.
messages: C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.
messages: Cell inner membrane
messages: Component of the cbb3-type cytochrome c oxidase.

318161:SDEN RS11355
gene id: 318161:SDEN_RS11355
uniprot id: Q12M62
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

318161:SDEN RS18920
gene id: 318161:SDEN_RS18920
uniprot id: Q12I10
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Secreted

318161:SDEN RS18210
gene id: 318161:SDEN_RS18210
uniprot id: Q12IE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

318161:SDEN RS08140
gene id: 318161:SDEN_RS08140
uniprot id: Q12NY3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
messages: Homodimer.

318161:SDEN RS04320
gene id: 318161:SDEN_RS04320
uniprot id: Q12R08
names: Function
names: Similarity
names: Subunit
messages: Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
messages: Belongs to the ZapA family. Type 1 subfamily.
messages: Homodimer. Interacts with FtsZ.

318161:SDEN RS00330
gene id: 318161:SDEN_RS00330
uniprot id: Q12T66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

318161:SDEN RS08130
gene id: 318161:SDEN_RS08130
uniprot id: Q12NY5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.

318161:SDEN RS16115
gene id: 318161:SDEN_RS16115
uniprot id: Q12JJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

318161:SDEN RS19175
gene id: 318161:SDEN_RS19175
uniprot id: Q12HW4
names: Similarity
messages: Belongs to the peptidase C40 family.

318161:SDEN RS01740
gene id: 318161:SDEN_RS01740
uniprot id: Q12SF2
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.

318161:SDEN RS10895
gene id: 318161:SDEN_RS10895
uniprot id: Q12MF3
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

318161:SDEN RS11680
gene id: 318161:SDEN_RS11680
uniprot id: Q12LZ6
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

318161:SDEN RS14545
gene id: 318161:SDEN_RS14545
uniprot id: Q12KE8
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS01855
gene id: 318161:SDEN_RS01855
uniprot id: Q12SC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane

318161:SDEN RS14150
gene id: 318161:SDEN_RS14150
uniprot id: Q12KM6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

318161:SDEN RS06790
gene id: 318161:SDEN_RS06790
uniprot id: Q12PN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

318161:SDEN RS11865
gene id: 318161:SDEN_RS11865
uniprot id: Q12LV9
names: Cofactor
messages: Binds 2 Mg(2+) ions per monomer.

318161:SDEN RS09060
gene id: 318161:SDEN_RS09060
uniprot id: Q12NF5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

318161:SDEN RS02695
gene id: 318161:SDEN_RS02695
uniprot id: Q12RX1
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS13280
gene id: 318161:SDEN_RS13280
uniprot id: Q12L48
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

318161:SDEN RS13755
gene id: 318161:SDEN_RS13755
uniprot id: Q12KV3
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

318161:SDEN RS17315
gene id: 318161:SDEN_RS17315
uniprot id: Q12IW7
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

318161:SDEN RS06800
gene id: 318161:SDEN_RS06800
uniprot id: Q12PN5
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

318161:SDEN RS09435
gene id: 318161:SDEN_RS09435
uniprot id: Q12N82
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS09155
gene id: 318161:SDEN_RS09155
uniprot id: Q12ND6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapB family.
messages: Cell inner membrane
messages: Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.

318161:SDEN RS12595
gene id: 318161:SDEN_RS12595
uniprot id: Q12LG8
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

318161:SDEN RS05655
gene id: 318161:SDEN_RS05655
uniprot id: Q12QA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

318161:SDEN RS14665
gene id: 318161:SDEN_RS14665
uniprot id: Q12KC4
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
messages: Comprises two domains: an N-terminal domain containing the nucleotidyltransferase activity and a C-terminal HD domain associated with both phosphodiesterase and phosphatase activities.
messages: Magnesium is required for nucleotidyltransferase activity.
messages: Monomer. Can also form homodimers and oligomers.
messages: Nickel for phosphatase activity.

318161:SDEN RS02945
gene id: 318161:SDEN_RS02945
uniprot id: Q12RS5
names: Similarity
messages: Belongs to the MipA/OmpV family.

318161:SDEN RS05315
gene id: 318161:SDEN_RS05315
uniprot id: Q12QG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

318161:SDEN RS01215
gene id: 318161:SDEN_RS01215
uniprot id: Q12SQ0
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS02350
gene id: 318161:SDEN_RS02350
uniprot id: Q12S39
names: Function
names: Similarity
messages: Belongs to the Dus family. DusB subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

318161:SDEN RS15285
gene id: 318161:SDEN_RS15285
uniprot id: Q12K06
names: Caution
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS03835
gene id: 318161:SDEN_RS03835
uniprot id: Q12R97
names: Similarity
messages: Belongs to the GST superfamily.

318161:SDEN RS12495
gene id: 318161:SDEN_RS12495
uniprot id: Q12LI9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

318161:SDEN RS19550
gene id: 318161:SDEN_RS19550
uniprot id: Q12HP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.

318161:SDEN RS13905
gene id: 318161:SDEN_RS13905
uniprot id: Q12KS3
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

318161:SDEN RS04340
gene id: 318161:SDEN_RS04340
uniprot id: Q12R04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

318161:SDEN RS11665
gene id: 318161:SDEN_RS11665
uniprot id: Q12LZ9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

318161:SDEN RS00405
gene id: 318161:SDEN_RS00405
uniprot id: Q12T51
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

318161:SDEN RS19585
gene id: 318161:SDEN_RS19585
uniprot id: Q12HN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Membrane

318161:SDEN RS18365
gene id: 318161:SDEN_RS18365
uniprot id: Q12IB8
names: Similarity
messages: Belongs to the asparagine synthetase family.

318161:SDEN RS18225
gene id: 318161:SDEN_RS18225
uniprot id: Q12IE5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmD family.
messages: Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle.

318161:SDEN RS14030
gene id: 318161:SDEN_RS14030
uniprot id: Q12KP8
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.

318161:SDEN RS07865
gene id: 318161:SDEN_RS07865
uniprot id: Q12P38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

318161:SDEN RS02650
gene id: 318161:SDEN_RS02650
uniprot id: Q12RY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Periplasm

318161:SDEN RS15990
gene id: 318161:SDEN_RS15990
uniprot id: Q12JM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
messages: Cytoplasm

318161:SDEN RS13035
gene id: 318161:SDEN_RS13035
uniprot id: Q12L82
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

318161:SDEN RS07260
gene id: 318161:SDEN_RS07260
uniprot id: Q12PE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

318161:SDEN RS00270
gene id: 318161:SDEN_RS00270
uniprot id: Q12T78
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

318161:SDEN RS02655
gene id: 318161:SDEN_RS02655
uniprot id: Q12RX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AFG1 ATPase family. ZapE subfamily.
messages: Cytoplasm
messages: Interacts with FtsZ.
messages: Reduces the stability of FtsZ polymers in the presence of ATP.

318161:SDEN RS03930
gene id: 318161:SDEN_RS03930
uniprot id: Q12R78
names: Similarity
names: Subunit
messages: Belongs to the RNase H family.
messages: Monomer.

318161:SDEN RS07680
gene id: 318161:SDEN_RS07680
uniprot id: Q12P74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YciB family.
messages: Cell inner membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.

318161:SDEN RS01960
gene id: 318161:SDEN_RS01960
uniprot id: Q12SB2
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

318161:SDEN RS03075
gene id: 318161:SDEN_RS03075
uniprot id: Q12RP9
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS03595
gene id: 318161:SDEN_RS03595
uniprot id: Q12RE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

318161:SDEN RS15680
gene id: 318161:SDEN_RS15680
uniprot id: Q12JT3
names: Similarity
messages: Belongs to the peptidase M4 family.

318161:SDEN RS18340
gene id: 318161:SDEN_RS18340
uniprot id: Q12IC3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NfuA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is presumably bound at the interface of two monomers.
messages: Homodimer.
messages: Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.

318161:SDEN RS16560
gene id: 318161:SDEN_RS16560
uniprot id: Q12JB4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

318161:SDEN RS17540
gene id: 318161:SDEN_RS17540
uniprot id: Q12IS3
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

318161:SDEN RS10550
gene id: 318161:SDEN_RS10550
uniprot id: Q12MM1
names: Similarity
messages: Belongs to the transglycosylase Slt family.

318161:SDEN RS18045
gene id: 318161:SDEN_RS18045
uniprot id: Q12II0
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS09565
gene id: 318161:SDEN_RS09565
uniprot id: Q12N57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

318161:SDEN RS03965
gene id: 318161:SDEN_RS03965
uniprot id: Q12R71
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS07800
gene id: 318161:SDEN_RS07800
uniprot id: Q12P51
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS00810
gene id: 318161:SDEN_RS00810
uniprot id: Q12SX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

318161:SDEN RS12720
gene id: 318161:SDEN_RS12720
uniprot id: Q12LE3
names: Function
names: Similarity
messages: Belongs to the TrpC family.
messages: Belongs to the TrpF family.
messages: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain.
messages: In the C-terminal section; belongs to the TrpF family.
messages: In the N-terminal section; belongs to the TrpC family.

318161:SDEN RS19000
gene id: 318161:SDEN_RS19000
uniprot id: Q12HZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliH family.
messages: Cytoplasm
messages: Needed for flagellar regrowth and assembly.

318161:SDEN RS04290
gene id: 318161:SDEN_RS04290
uniprot id: Q12R14
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

318161:SDEN RS18260
gene id: 318161:SDEN_RS18260
uniprot id: Q12ID8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.
messages: Cell inner membrane
messages: Involved in transporting aromatic amino acids across the cytoplasmic membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

318161:SDEN RS08340
gene id: 318161:SDEN_RS08340
uniprot id: Q12NU5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

318161:SDEN RS02135
gene id: 318161:SDEN_RS02135
uniprot id: Q12S78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.

318161:SDEN RS10790
gene id: 318161:SDEN_RS10790
uniprot id: Q12MH4
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

318161:SDEN RS09325
gene id: 318161:SDEN_RS09325
uniprot id: Q12NA1
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

318161:SDEN RS04970
gene id: 318161:SDEN_RS04970
uniprot id: Q12QN2
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

318161:SDEN RS14175
gene id: 318161:SDEN_RS14175
uniprot id: Q12KM1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

318161:SDEN RS16475
gene id: 318161:SDEN_RS16475
uniprot id: Q12JD1
names: Similarity
messages: Belongs to the SfsA family.

318161:SDEN RS06700
gene id: 318161:SDEN_RS06700
uniprot id: Q12PQ4
names: Similarity
messages: Belongs to the polysaccharide synthase family.

318161:SDEN RS00615
gene id: 318161:SDEN_RS00615
uniprot id: Q12T10
names: Similarity
messages: Belongs to the HSP15 family.

318161:SDEN RS13235
gene id: 318161:SDEN_RS13235
uniprot id: Q12L57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone-like protein H-NS family.
messages: nucleoid

318161:SDEN RS06820
gene id: 318161:SDEN_RS06820
uniprot id: Q12PN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: Membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

318161:SDEN RS14400
gene id: 318161:SDEN_RS14400
uniprot id: Q12KH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E.
messages: Belongs to the RseA family.
messages: Cell inner membrane
messages: Interacts 1:1 with ECF RNA polymerase sigma-E (RpoE); this inhibits the interaction of sigma-E with the RNA polymerase catalytic core and leads to a decreased expression of sigma-E-regulated genes. Interacts with RseB.

318161:SDEN RS11900
gene id: 318161:SDEN_RS11900
uniprot id: Q12LV2
names: Similarity
messages: Belongs to the fabD family.

318161:SDEN RS08675
gene id: 318161:SDEN_RS08675
uniprot id: Q12NM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.
messages: Homotetramer; dimer of dimers.
messages: Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.

318161:SDEN RS05195
gene id: 318161:SDEN_RS05195
uniprot id: Q12QI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

318161:SDEN RS06200
gene id: 318161:SDEN_RS06200
uniprot id: Q12PZ7
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

318161:SDEN RS18090
gene id: 318161:SDEN_RS18090
uniprot id: Q12IH1
names: Similarity
messages: Belongs to the SCO1/2 family.

318161:SDEN RS17730
gene id: 318161:SDEN_RS17730
uniprot id: Q12IN7
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

318161:SDEN RS08535
gene id: 318161:SDEN_RS08535
uniprot id: Q12NQ5
names: Similarity
messages: Belongs to the UPF0229 family.

318161:SDEN RS11915
gene id: 318161:SDEN_RS11915
uniprot id: Q12LU9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

318161:SDEN RS03050
gene id: 318161:SDEN_RS03050
uniprot id: Q12RQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS15020
gene id: 318161:SDEN_RS15020
uniprot id: Q12K59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

318161:SDEN RS04465
gene id: 318161:SDEN_RS04465
uniprot id: Q12QY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

318161:SDEN RS00895
gene id: 318161:SDEN_RS00895
uniprot id: Q12SW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

318161:SDEN RS13160
gene id: 318161:SDEN_RS13160
uniprot id: Q12L63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

318161:SDEN RS07760
gene id: 318161:SDEN_RS07760
uniprot id: Q12P59
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

318161:SDEN RS08565
gene id: 318161:SDEN_RS08565
uniprot id: Q12NP9
names: Similarity
messages: Belongs to the DnaA family.

318161:SDEN RS17840
gene id: 318161:SDEN_RS17840
uniprot id: Q12IL5
names: Similarity
messages: Belongs to the RutC family.

318161:SDEN RS05975
gene id: 318161:SDEN_RS05975
uniprot id: Q12Q40
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

318161:SDEN RS12480
gene id: 318161:SDEN_RS12480
uniprot id: Q12LJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS00420
gene id: 318161:SDEN_RS00420
uniprot id: Q12T48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

318161:SDEN RS10830
gene id: 318161:SDEN_RS10830
uniprot id: Q12MG5
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS18165
gene id: 318161:SDEN_RS18165
uniprot id: Q12IF7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

318161:SDEN RS00240
gene id: 318161:SDEN_RS00240
uniprot id: Q12T84
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

318161:SDEN RS11845
gene id: 318161:SDEN_RS11845
uniprot id: Q12LW3
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS18110
gene id: 318161:SDEN_RS18110
uniprot id: Q12IG7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

318161:SDEN RS19615
gene id: 318161:SDEN_RS19615
uniprot id: Q12HN2
names: Similarity
messages: Belongs to the asparagine synthetase family.

318161:SDEN RS05000
gene id: 318161:SDEN_RS05000
uniprot id: Q12QM6
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

318161:SDEN RS07225
gene id: 318161:SDEN_RS07225
uniprot id: Q12PF5
names: Similarity
messages: Belongs to the GST superfamily.

318161:SDEN RS01635
gene id: 318161:SDEN_RS01635
uniprot id: Q12SH2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

318161:SDEN RS10710
gene id: 318161:SDEN_RS10710
uniprot id: Q12MJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

318161:SDEN RS05410
gene id: 318161:SDEN_RS05410
uniprot id: Q12QE8
names: Function
names: Similarity
messages: Belongs to the UbiT family.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Likely functions as an accessory factor.

318161:SDEN RS05660
gene id: 318161:SDEN_RS05660
uniprot id: Q12QA2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

318161:SDEN RS06610
gene id: 318161:SDEN_RS06610
uniprot id: Q12PS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

318161:SDEN RS10810
gene id: 318161:SDEN_RS10810
uniprot id: Q12MG9
names: Similarity
messages: Belongs to the asparagine synthetase family.

318161:SDEN RS14445
gene id: 318161:SDEN_RS14445
uniprot id: Q12KG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

318161:SDEN RS11220
gene id: 318161:SDEN_RS11220
uniprot id: Q12M89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

318161:SDEN RS10815
gene id: 318161:SDEN_RS10815
uniprot id: Q12MG8
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

318161:SDEN RS09080
gene id: 318161:SDEN_RS09080
uniprot id: Q12NF1
names: Similarity
messages: Belongs to the AlaDH/PNT family.

318161:SDEN RS18270
gene id: 318161:SDEN_RS18270
uniprot id: Q12ID6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

318161:SDEN RS14190
gene id: 318161:SDEN_RS14190
uniprot id: Q12KL8
names: Similarity
messages: Belongs to the UPF0246 family.

318161:SDEN RS09685
gene id: 318161:SDEN_RS09685
uniprot id: Q12N34
names: Similarity
messages: Belongs to the MbcT/ParT/Res family.

318161:SDEN RS17705
gene id: 318161:SDEN_RS17705
uniprot id: Q12IP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

318161:SDEN RS07765
gene id: 318161:SDEN_RS07765
uniprot id: Q12P58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
messages: Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS05220
gene id: 318161:SDEN_RS05220
uniprot id: Q12QI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

318161:SDEN RS03430
gene id: 318161:SDEN_RS03430
uniprot id: Q12RH7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS07675
gene id: 318161:SDEN_RS07675
uniprot id: Q12P75
names: Similarity
messages: Belongs to the YciI family.

318161:SDEN RS00650
gene id: 318161:SDEN_RS00650
uniprot id: Q12T03
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GSP I family.
messages: Cell inner membrane
messages: Cleaved by prepilin peptidase.
messages: Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane
messages: Type II secretion is composed of four main components: the outer membrane complex, the inner membrane complex, the cytoplasmic secretion ATPase and the periplasm-spanning pseudopilus.

318161:SDEN RS00955
gene id: 318161:SDEN_RS00955
uniprot id: Q12SV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

318161:SDEN RS17435
gene id: 318161:SDEN_RS17435
uniprot id: Q12IU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

318161:SDEN RS18070
gene id: 318161:SDEN_RS18070
uniprot id: Q12IH5
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

318161:SDEN RS08355
gene id: 318161:SDEN_RS08355
uniprot id: Q12NU2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

318161:SDEN RS13605
gene id: 318161:SDEN_RS13605
uniprot id: Q12KY3
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.

318161:SDEN RS11180
gene id: 318161:SDEN_RS11180
uniprot id: Q12M97
names: Subcellular Location Annotation
messages: Cell inner membrane

318161:SDEN RS18850
gene id: 318161:SDEN_RS18850
uniprot id: Q12I24
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.

318161:SDEN RS17855
gene id: 318161:SDEN_RS17855
uniprot id: Q12IL2
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

318161:SDEN RS06835
gene id: 318161:SDEN_RS06835
uniprot id: Q12PM8
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

318161:SDEN RS17440
gene id: 318161:SDEN_RS17440
uniprot id: Q12IU3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

318161:SDEN RS19485
gene id: 318161:SDEN_RS19485
uniprot id: Q12HQ7
names: Similarity
messages: Belongs to the pirin family.

318161:SDEN RS14170
gene id: 318161:SDEN_RS14170
uniprot id: Q12KM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

318161:SDEN RS01825
gene id: 318161:SDEN_RS01825
uniprot id: Q12SD5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

318161:SDEN RS19590
gene id: 318161:SDEN_RS19590
uniprot id: Q12HN7
names: Function
names: Similarity
messages: Belongs to the esterase D family.
messages: Serine hydrolase involved in the detoxification of formaldehyde.

318161:SDEN RS00170
gene id: 318161:SDEN_RS00170
uniprot id: Q12T95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

318161:SDEN RS01780
gene id: 318161:SDEN_RS01780
uniprot id: Q12SE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

318161:SDEN RS13405
gene id: 318161:SDEN_RS13405
uniprot id: Q12L23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell inner membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

318161:SDEN RS05965
gene id: 318161:SDEN_RS05965
uniprot id: Q12Q42
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

318161:SDEN RS05240
gene id: 318161:SDEN_RS05240
uniprot id: Q12QI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

318161:SDEN RS01040
gene id: 318161:SDEN_RS01040
uniprot id: Q12ST4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

318161:SDEN RS13725
gene id: 318161:SDEN_RS13725
uniprot id: Q12KV9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

318161:SDEN RS14680
gene id: 318161:SDEN_RS14680
uniprot id: Q12KC1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane

318161:SDEN RS16715
gene id: 318161:SDEN_RS16715
uniprot id: Q12J86
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

318161:SDEN RS01850
gene id: 318161:SDEN_RS01850
uniprot id: Q12SD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

318161:SDEN RS00980
gene id: 318161:SDEN_RS00980
uniprot id: Q12SU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

318161:SDEN RS01225
gene id: 318161:SDEN_RS01225
uniprot id: Q12SP8
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
messages: Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).

318161:SDEN RS17070
gene id: 318161:SDEN_RS17070
uniprot id: Q12J16
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

318161:SDEN RS13490
gene id: 318161:SDEN_RS13490
uniprot id: Q12L06
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

318161:SDEN RS09835
gene id: 318161:SDEN_RS09835
uniprot id: Q12N09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

318161:SDEN RS05325
gene id: 318161:SDEN_RS05325
uniprot id: Q12QG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

318161:SDEN RS02595
gene id: 318161:SDEN_RS02595
uniprot id: Q12RZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
messages: Homotetramer.

318161:SDEN RS03015
gene id: 318161:SDEN_RS03015
uniprot id: Q12RR1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

318161:SDEN RS08285
gene id: 318161:SDEN_RS08285
uniprot id: Q12NV6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

318161:SDEN RS05165
gene id: 318161:SDEN_RS05165
uniprot id: Q12QJ5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

318161:SDEN RS05695
gene id: 318161:SDEN_RS05695
uniprot id: Q12Q95
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.

318161:SDEN RS09925
gene id: 318161:SDEN_RS09925
uniprot id: Q12MZ1
names: Similarity
messages: Belongs to the asparaginase 1 family.

318161:SDEN RS10980
gene id: 318161:SDEN_RS10980
uniprot id: Q12MD7
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

318161:SDEN RS12535
gene id: 318161:SDEN_RS12535
uniprot id: Q12LI1
names: Similarity
messages: Belongs to the FeoA family.

318161:SDEN RS17800
gene id: 318161:SDEN_RS17800
uniprot id: Q12IM3
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS01550
gene id: 318161:SDEN_RS01550
uniprot id: Q12SJ1
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

318161:SDEN RS05675
gene id: 318161:SDEN_RS05675
uniprot id: Q12Q99
names: Similarity
messages: Belongs to the peptidase M13 family.

318161:SDEN RS16540
gene id: 318161:SDEN_RS16540
uniprot id: Q12JB8
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS08440
gene id: 318161:SDEN_RS08440
uniprot id: Q12NS4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

318161:SDEN RS03200
gene id: 318161:SDEN_RS03200
uniprot id: Q12RM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

318161:SDEN RS15185
gene id: 318161:SDEN_RS15185
uniprot id: Q12K26
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

318161:SDEN RS01190
gene id: 318161:SDEN_RS01190
uniprot id: Q12SQ5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

318161:SDEN RS11430
gene id: 318161:SDEN_RS11430
uniprot id: Q12M46
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
messages: Cell inner membrane
messages: Homodimer.
messages: In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.

318161:SDEN RS07180
gene id: 318161:SDEN_RS07180
uniprot id: Q12PF9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

318161:SDEN RS12005
gene id: 318161:SDEN_RS12005
uniprot id: Q12LT1
names: Cofactor
names: Similarity
messages: Belongs to the nitroreductase family.
messages: Binds 1 FMN per subunit.

318161:SDEN RS14440
gene id: 318161:SDEN_RS14440
uniprot id: Q12KG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS15915
gene id: 318161:SDEN_RS15915
uniprot id: Q12JN9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
messages: Cell membrane
messages: Homohexamer.

318161:SDEN RS11350
gene id: 318161:SDEN_RS11350
uniprot id: Q12M63
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

318161:SDEN RS06070
gene id: 318161:SDEN_RS06070
uniprot id: Q12Q24
names: Similarity
messages: Belongs to the isopentenyl phosphate kinase family.

318161:SDEN RS01735
gene id: 318161:SDEN_RS01735
uniprot id: Q12SF3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

318161:SDEN RS02385
gene id: 318161:SDEN_RS02385
uniprot id: Q12S32
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

318161:SDEN RS10800
gene id: 318161:SDEN_RS10800
uniprot id: Q12MH1
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

318161:SDEN RS04785
gene id: 318161:SDEN_RS04785
uniprot id: Q12QR8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

318161:SDEN RS18195
gene id: 318161:SDEN_RS18195
uniprot id: Q12IF1
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS11390
gene id: 318161:SDEN_RS11390
uniprot id: Q12M55
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS08175
gene id: 318161:SDEN_RS08175
uniprot id: Q12NX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

318161:SDEN RS09755
gene id: 318161:SDEN_RS09755
uniprot id: Q12N25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

318161:SDEN RS14915
gene id: 318161:SDEN_RS14915
uniprot id: Q12K80
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

318161:SDEN RS18845
gene id: 318161:SDEN_RS18845
uniprot id: Q12I25
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

318161:SDEN RS00090
gene id: 318161:SDEN_RS00090
uniprot id: Q12TB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

318161:SDEN RS05970
gene id: 318161:SDEN_RS05970
uniprot id: Q12Q41
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

318161:SDEN RS19875
gene id: 318161:SDEN_RS19875
uniprot id: Q12LP4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.
messages: The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
messages: The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.

318161:SDEN RS08115
gene id: 318161:SDEN_RS08115
uniprot id: Q12NY8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

318161:SDEN RS14435
gene id: 318161:SDEN_RS14435
uniprot id: Q12KG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

318161:SDEN RS11340
gene id: 318161:SDEN_RS11340
uniprot id: Q12M65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

318161:SDEN RS14110
gene id: 318161:SDEN_RS14110
uniprot id: Q12KN4
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS09160
gene id: 318161:SDEN_RS09160
uniprot id: Q12ND5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

318161:SDEN RS17805
gene id: 318161:SDEN_RS17805
uniprot id: Q12IM2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

318161:SDEN RS08900
gene id: 318161:SDEN_RS08900
uniprot id: Q12NI7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS02440
gene id: 318161:SDEN_RS02440
uniprot id: Q12S21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RraA family.
messages: Cytoplasm
messages: Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome.
messages: Homotrimer. Binds to both RNA-binding sites in the C-terminal region of Rne and to RhlB.

318161:SDEN RS00855
gene id: 318161:SDEN_RS00855
uniprot id: Q12SX2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS12500
gene id: 318161:SDEN_RS12500
uniprot id: Q12LI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0208 family.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS06440
gene id: 318161:SDEN_RS06440
uniprot id: Q12PV5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

318161:SDEN RS01700
gene id: 318161:SDEN_RS01700
uniprot id: Q12SG0
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Toroid-shaped homodecamer, composed of two pentamers of five dimers.

318161:SDEN RS04845
gene id: 318161:SDEN_RS04845
uniprot id: Q12QQ6
names: Cofactor
names: Function
names: Subunit
messages: Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.
messages: Binds 1 FAD per subunit.
messages: Binds 1 FMN per subunit.
messages: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.

318161:SDEN RS00345
gene id: 318161:SDEN_RS00345
uniprot id: Q12T63
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS09240
gene id: 318161:SDEN_RS09240
uniprot id: Q12NB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

318161:SDEN RS15485
gene id: 318161:SDEN_RS15485
uniprot id: Q12JX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. RsmC family.
messages: Cytoplasm
messages: Monomer.
messages: Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.

318161:SDEN RS11240
gene id: 318161:SDEN_RS11240
uniprot id: Q12M85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS12400
gene id: 318161:SDEN_RS12400
uniprot id: Q12LK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

318161:SDEN RS08525
gene id: 318161:SDEN_RS08525
uniprot id: Q12NQ7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: Multifunctional regulator of fatty acid metabolism.

318161:SDEN RS05945
gene id: 318161:SDEN_RS05945
uniprot id: Q12Q46
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

318161:SDEN RS18940
gene id: 318161:SDEN_RS18940
uniprot id: Q12I06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: Membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

318161:SDEN RS18955
gene id: 318161:SDEN_RS18955
uniprot id: Q12I03
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

318161:SDEN RS03995
gene id: 318161:SDEN_RS03995
uniprot id: Q12R65
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS01725
gene id: 318161:SDEN_RS01725
uniprot id: Q12SF5
names: Similarity
messages: Belongs to the UPF0758 family.

318161:SDEN RS01870
gene id: 318161:SDEN_RS01870
uniprot id: Q12SC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

318161:SDEN RS05405
gene id: 318161:SDEN_RS05405
uniprot id: Q12QE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiU subfamily.
messages: Forms an heterodimer with UbiV.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

318161:SDEN RS11890
gene id: 318161:SDEN_RS11890
uniprot id: Q12LV4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

318161:SDEN RS02980
gene id: 318161:SDEN_RS02980
uniprot id: Q12RR8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

318161:SDEN RS15055
gene id: 318161:SDEN_RS15055
uniprot id: Q12K52
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

318161:SDEN RS15390
gene id: 318161:SDEN_RS15390
uniprot id: Q12JZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

318161:SDEN RS01450
gene id: 318161:SDEN_RS01450
uniprot id: Q12SL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS18820
gene id: 318161:SDEN_RS18820
uniprot id: Q12I30
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

318161:SDEN RS01840
gene id: 318161:SDEN_RS01840
uniprot id: Q12SD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
messages: Cell inner membrane

318161:SDEN RS17465
gene id: 318161:SDEN_RS17465
uniprot id: Q12IT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

318161:SDEN RS19575
gene id: 318161:SDEN_RS19575
uniprot id: Q12HP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

318161:SDEN RS09920
gene id: 318161:SDEN_RS09920
uniprot id: Q12MZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S49 family.
messages: Cell inner membrane

318161:SDEN RS05740
gene id: 318161:SDEN_RS05740
uniprot id: Q12Q86
names: Similarity
messages: Belongs to the PhzF family.

318161:SDEN RS00970
gene id: 318161:SDEN_RS00970
uniprot id: Q12SU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

318161:SDEN RS17825
gene id: 318161:SDEN_RS17825
uniprot id: Q12IL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

318161:SDEN RS08725
gene id: 318161:SDEN_RS08725
uniprot id: Q12NL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

318161:SDEN RS08550
gene id: 318161:SDEN_RS08550
uniprot id: Q12NQ2
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.

318161:SDEN RS14010
gene id: 318161:SDEN_RS14010
uniprot id: Q12KQ2
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

318161:SDEN RS17215
gene id: 318161:SDEN_RS17215
uniprot id: Q12IY6
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS00720
gene id: 318161:SDEN_RS00720
uniprot id: Q12SZ2
names: Subcellular Location Annotation
messages: Secreted

318161:SDEN RS03040
gene id: 318161:SDEN_RS03040
uniprot id: Q12RQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS00495
gene id: 318161:SDEN_RS00495
uniprot id: Q12T34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiC family.
messages: Cytoplasm
messages: Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.

318161:SDEN RS04075
gene id: 318161:SDEN_RS04075
uniprot id: Q12R49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

318161:SDEN RS12265
gene id: 318161:SDEN_RS12265
uniprot id: Q12LN0
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS10475
gene id: 318161:SDEN_RS10475
uniprot id: Q12MN3
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

318161:SDEN RS07050
gene id: 318161:SDEN_RS07050
uniprot id: Q12PI5
names: Similarity
messages: Belongs to the MlaA family.

318161:SDEN RS07620
gene id: 318161:SDEN_RS07620
uniprot id: Q12P86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS17160
gene id: 318161:SDEN_RS17160
uniprot id: Q12IZ8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

318161:SDEN RS00920
gene id: 318161:SDEN_RS00920
uniprot id: Q12SV9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

318161:SDEN RS19340
gene id: 318161:SDEN_RS19340
uniprot id: Q12HT6
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

318161:SDEN RS02415
gene id: 318161:SDEN_RS02415
uniprot id: Q12S26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

318161:SDEN RS15095
gene id: 318161:SDEN_RS15095
uniprot id: Q12K43
names: Similarity
messages: Belongs to the P(II) protein family.

318161:SDEN RS07515
gene id: 318161:SDEN_RS07515
uniprot id: Q12PA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

318161:SDEN RS13950
gene id: 318161:SDEN_RS13950
uniprot id: Q12KR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

318161:SDEN RS09475
gene id: 318161:SDEN_RS09475
uniprot id: Q12N75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

318161:SDEN RS04715
gene id: 318161:SDEN_RS04715
uniprot id: Q12QT2
names: Similarity
messages: Belongs to the Nudix hydrolase family.

318161:SDEN RS18320
gene id: 318161:SDEN_RS18320
uniprot id: Q12IC7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell inner membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.

318161:SDEN RS19045
gene id: 318161:SDEN_RS19045
uniprot id: Q12HY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

318161:SDEN RS10515
gene id: 318161:SDEN_RS10515
uniprot id: Q12MM8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

318161:SDEN RS07480
gene id: 318161:SDEN_RS07480
uniprot id: Q12PB0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

318161:SDEN RS05750
gene id: 318161:SDEN_RS05750
uniprot id: Q12Q84
names: Cofactor
messages: Binds 3 heme c groups covalently per subunit.

318161:SDEN RS13065
gene id: 318161:SDEN_RS13065
uniprot id: Q12L76
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

318161:SDEN RS08415
gene id: 318161:SDEN_RS08415
uniprot id: Q12NS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

318161:SDEN RS18335
gene id: 318161:SDEN_RS18335
uniprot id: Q12IC4
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS03400
gene id: 318161:SDEN_RS03400
uniprot id: Q12RI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS11130
gene id: 318161:SDEN_RS11130
uniprot id: Q12MA7
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

318161:SDEN RS01565
gene id: 318161:SDEN_RS01565
uniprot id: Q12SI6
names: Function
names: Subunit
messages: Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins.
messages: Homodimer.

318161:SDEN RS16450
gene id: 318161:SDEN_RS16450
uniprot id: Q12JD6
names: Function
names: Similarity
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

318161:SDEN RS08950
gene id: 318161:SDEN_RS08950
uniprot id: Q12NH7
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

318161:SDEN RS02235
gene id: 318161:SDEN_RS02235
uniprot id: Q12S62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

318161:SDEN RS18980
gene id: 318161:SDEN_RS18980
uniprot id: Q12HZ8
names: Function
names: Similarity
messages: Belongs to the FlgM family.
messages: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

318161:SDEN RS04485
gene id: 318161:SDEN_RS04485
uniprot id: Q12QX8
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS02640
gene id: 318161:SDEN_RS02640
uniprot id: Q12RY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

318161:SDEN RS06830
gene id: 318161:SDEN_RS06830
uniprot id: Q12PM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.
messages: In the C-terminal section; belongs to the glycosyl hydrolase 73 family.
messages: In the N-terminal section; belongs to the FlgJ family.
messages: Periplasm

318161:SDEN RS13380
gene id: 318161:SDEN_RS13380
uniprot id: Q12L28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

318161:SDEN RS03715
gene id: 318161:SDEN_RS03715
uniprot id: Q12RC1
names: Function
names: Similarity
messages: Belongs to the GMC oxidoreductase family.
messages: Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.

318161:SDEN RS13090
gene id: 318161:SDEN_RS13090
uniprot id: Q12L71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell inner membrane
messages: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).

318161:SDEN RS04735
gene id: 318161:SDEN_RS04735
uniprot id: Q12QS8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

318161:SDEN RS07635
gene id: 318161:SDEN_RS07635
uniprot id: Q12P83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

318161:SDEN RS05400
gene id: 318161:SDEN_RS05400
uniprot id: Q12QF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiV subfamily.
messages: Forms an heterodimer with UbiU.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiU, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

318161:SDEN RS11515
gene id: 318161:SDEN_RS11515
uniprot id: Q12M30
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS14100
gene id: 318161:SDEN_RS14100
uniprot id: Q12KN6
names: Similarity
messages: Belongs to the P(II) protein family.

318161:SDEN RS18020
gene id: 318161:SDEN_RS18020
uniprot id: Q12II5
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

318161:SDEN RS14690
gene id: 318161:SDEN_RS14690
uniprot id: Q12KB9
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

318161:SDEN RS17630
gene id: 318161:SDEN_RS17630
uniprot id: Q12IQ5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

318161:SDEN RS12960
gene id: 318161:SDEN_RS12960
uniprot id: Q12L97
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

318161:SDEN RS08590
gene id: 318161:SDEN_RS08590
uniprot id: Q12NP4
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

318161:SDEN RS07275
gene id: 318161:SDEN_RS07275
uniprot id: Q12PE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

318161:SDEN RS16710
gene id: 318161:SDEN_RS16710
uniprot id: Q12J87
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

318161:SDEN RS05255
gene id: 318161:SDEN_RS05255
uniprot id: Q12QH9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

318161:SDEN RS10940
gene id: 318161:SDEN_RS10940
uniprot id: Q12ME4
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

318161:SDEN RS00135
gene id: 318161:SDEN_RS00135
uniprot id: Q12TA2
names: Similarity
messages: Belongs to the Smg family.

318161:SDEN RS06500
gene id: 318161:SDEN_RS06500
uniprot id: Q12PU4
names: Cofactor
messages: Can also use Mn(2+) ion.

318161:SDEN RS13295
gene id: 318161:SDEN_RS13295
uniprot id: Q12L45
names: Similarity
messages: Belongs to the glutathione peroxidase family.

318161:SDEN RS13370
gene id: 318161:SDEN_RS13370
uniprot id: Q12L30
names: Similarity
messages: Belongs to the MotB family.

318161:SDEN RS09445
gene id: 318161:SDEN_RS09445
uniprot id: Q12N81
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

318161:SDEN RS14645
gene id: 318161:SDEN_RS14645
uniprot id: Q12KC8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS03215
gene id: 318161:SDEN_RS03215
uniprot id: Q12RM2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MetJ family.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS07770
gene id: 318161:SDEN_RS07770
uniprot id: Q12P57
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS04625
gene id: 318161:SDEN_RS04625
uniprot id: Q12QV0
names: Similarity
messages: Belongs to the peptidase M24B family.

318161:SDEN RS12915
gene id: 318161:SDEN_RS12915
uniprot id: Q12LA3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

318161:SDEN RS02365
gene id: 318161:SDEN_RS02365
uniprot id: Q12S36
names: Similarity
messages: Belongs to the thioredoxin family.

318161:SDEN RS12330
gene id: 318161:SDEN_RS12330
uniprot id: Q12LM1
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS17735
gene id: 318161:SDEN_RS17735
uniprot id: Q12IN6
names: Caution
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS01910
gene id: 318161:SDEN_RS01910
uniprot id: Q12SB8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: May bind 1 zinc ion per subunit.
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

318161:SDEN RS05155
gene id: 318161:SDEN_RS05155
uniprot id: Q12QJ7
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

318161:SDEN RS03600
gene id: 318161:SDEN_RS03600
uniprot id: Q12RE4
names: Similarity
messages: Belongs to the UPF0111 family.

318161:SDEN RS15660
gene id: 318161:SDEN_RS15660
uniprot id: Q12JT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

318161:SDEN RS06990
gene id: 318161:SDEN_RS06990
uniprot id: Q12PJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sigma-70 factor family. FliA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.

318161:SDEN RS06845
gene id: 318161:SDEN_RS06845
uniprot id: Q12PM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

318161:SDEN RS08640
gene id: 318161:SDEN_RS08640
uniprot id: Q12NN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS19690
gene id: 318161:SDEN_RS19690
uniprot id: Q12SJ9
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS15190
gene id: 318161:SDEN_RS15190
uniprot id: Q12K25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

318161:SDEN RS09545
gene id: 318161:SDEN_RS09545
uniprot id: Q12N61
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

318161:SDEN RS05810
gene id: 318161:SDEN_RS05810
uniprot id: Q12Q73
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

318161:SDEN RS08985
gene id: 318161:SDEN_RS08985
uniprot id: Q12NH0
names: Similarity
messages: Belongs to the peptidase S41A family.

318161:SDEN RS12925
gene id: 318161:SDEN_RS12925
uniprot id: Q12LA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

318161:SDEN RS04050
gene id: 318161:SDEN_RS04050
uniprot id: Q12R54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

318161:SDEN RS18960
gene id: 318161:SDEN_RS18960
uniprot id: Q12I02
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

318161:SDEN RS01205
gene id: 318161:SDEN_RS01205
uniprot id: Q12SQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SelU family.
messages: Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
messages: Monomer.

318161:SDEN RS14065
gene id: 318161:SDEN_RS14065
uniprot id: Q12KP3
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

318161:SDEN RS00910
gene id: 318161:SDEN_RS00910
uniprot id: Q12SW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

318161:SDEN RS10225
gene id: 318161:SDEN_RS10225
uniprot id: Q12MT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

318161:SDEN RS18835
gene id: 318161:SDEN_RS18835
uniprot id: Q12I27
names: Function
names: Similarity
names: Subunit
messages: A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis.
messages: Belongs to the YihI family.
messages: Interacts with Der.

318161:SDEN RS03980
gene id: 318161:SDEN_RS03980
uniprot id: Q12R68
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

318161:SDEN RS04790
gene id: 318161:SDEN_RS04790
uniprot id: Q12QR7
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

318161:SDEN RS12100
gene id: 318161:SDEN_RS12100
uniprot id: Q12LR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

318161:SDEN RS02475
gene id: 318161:SDEN_RS02475
uniprot id: Q12S14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS06620
gene id: 318161:SDEN_RS06620
uniprot id: Q12PS0
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

318161:SDEN RS15070
gene id: 318161:SDEN_RS15070
uniprot id: Q12K49
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS08490
gene id: 318161:SDEN_RS08490
uniprot id: Q12NR4
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

318161:SDEN RS10375
gene id: 318161:SDEN_RS10375
uniprot id: Q12MQ3
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

318161:SDEN RS19205
gene id: 318161:SDEN_RS19205
uniprot id: Q12HV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

318161:SDEN RS07040
gene id: 318161:SDEN_RS07040
uniprot id: Q12PI7
names: Similarity
messages: Belongs to the type III secretion exporter family.

318161:SDEN RS12780
gene id: 318161:SDEN_RS12780
uniprot id: Q12LD2
names: Similarity
messages: Belongs to the peptidase S16 family.

318161:SDEN RS16100
gene id: 318161:SDEN_RS16100
uniprot id: Q12JK2
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

318161:SDEN RS11055
gene id: 318161:SDEN_RS11055
uniprot id: Q12MC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

318161:SDEN RS06635
gene id: 318161:SDEN_RS06635
uniprot id: Q12PR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

318161:SDEN RS01025
gene id: 318161:SDEN_RS01025
uniprot id: Q12ST7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

318161:SDEN RS06300
gene id: 318161:SDEN_RS06300
uniprot id: Q12PX7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

318161:SDEN RS15835
gene id: 318161:SDEN_RS15835
uniprot id: Q12JQ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.

318161:SDEN RS08430
gene id: 318161:SDEN_RS08430
uniprot id: Q12NS6
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

318161:SDEN RS09300
gene id: 318161:SDEN_RS09300
uniprot id: Q12NA6
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

318161:SDEN RS09335
gene id: 318161:SDEN_RS09335
uniprot id: Q12N99
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

318161:SDEN RS13445
gene id: 318161:SDEN_RS13445
uniprot id: Q12L15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

318161:SDEN RS05200
gene id: 318161:SDEN_RS05200
uniprot id: Q12QI8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS18405
gene id: 318161:SDEN_RS18405
uniprot id: Q12IB0
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

318161:SDEN RS18265
gene id: 318161:SDEN_RS18265
uniprot id: Q12ID7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Cell inner membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

318161:SDEN RS08265
gene id: 318161:SDEN_RS08265
uniprot id: Q12NW0
names: Similarity
messages: Belongs to the Gfa family.

318161:SDEN RS17100
gene id: 318161:SDEN_RS17100
uniprot id: Q12J10
names: Similarity
messages: Belongs to the peptidase S8 family.

318161:SDEN RS01530
gene id: 318161:SDEN_RS01530
uniprot id: Q12SJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

318161:SDEN RS06240
gene id: 318161:SDEN_RS06240
uniprot id: Q12PY9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

318161:SDEN RS14795
gene id: 318161:SDEN_RS14795
uniprot id: Q12K99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

318161:SDEN RS07645
gene id: 318161:SDEN_RS07645
uniprot id: Q12P81
names: Similarity
messages: Belongs to the HesB/IscA family.

318161:SDEN RS18205
gene id: 318161:SDEN_RS18205
uniprot id: Q12IE9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

318161:SDEN RS09480
gene id: 318161:SDEN_RS09480
uniprot id: Q12N74
names: Subcellular Location Annotation
messages: Cytoplasm

318161:SDEN RS08695
gene id: 318161:SDEN_RS08695
uniprot id: Q12NM4
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

318161:SDEN RS02050
gene id: 318161:SDEN_RS02050
uniprot id: Q12S94
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

318161:SDEN RS06970
gene id: 318161:SDEN_RS06970
uniprot id: Q12PK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

318161:SDEN RS07795
gene id: 318161:SDEN_RS07795
uniprot id: Q12P52
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS05490
gene id: 318161:SDEN_RS05490
uniprot id: Q12QD4
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

318161:SDEN RS01835
gene id: 318161:SDEN_RS01835
uniprot id: Q12SD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsL family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Membrane
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

318161:SDEN RS07335
gene id: 318161:SDEN_RS07335
uniprot id: Q12PD9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

318161:SDEN RS18455
gene id: 318161:SDEN_RS18455
uniprot id: Q12IA0
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

318161:SDEN RS19535
gene id: 318161:SDEN_RS19535
uniprot id: Q12HP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

318161:SDEN RS16225
gene id: 318161:SDEN_RS16225
uniprot id: Q12JH7
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

318161:SDEN RS15045
gene id: 318161:SDEN_RS15045
uniprot id: Q12K54
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS01365
gene id: 318161:SDEN_RS01365
uniprot id: Q12SM8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS15755
gene id: 318161:SDEN_RS15755
uniprot id: Q12JS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

318161:SDEN RS06160
gene id: 318161:SDEN_RS06160
uniprot id: Q12Q05
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

318161:SDEN RS11820
gene id: 318161:SDEN_RS11820
uniprot id: Q12LW8
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

318161:SDEN RS11090
gene id: 318161:SDEN_RS11090
uniprot id: Q12MB4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane

318161:SDEN RS13360
gene id: 318161:SDEN_RS13360
uniprot id: Q12L32
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS04800
gene id: 318161:SDEN_RS04800
uniprot id: Q12QR5
names: Similarity
messages: Belongs to the UPF0162 family.

318161:SDEN RS11395
gene id: 318161:SDEN_RS11395
uniprot id: Q12M54
names: Similarity
messages: Belongs to the band 7/mec-2 family.

318161:SDEN RS12570
gene id: 318161:SDEN_RS12570
uniprot id: Q12LH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

318161:SDEN RS02430
gene id: 318161:SDEN_RS02430
uniprot id: Q12S23
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

318161:SDEN RS00610
gene id: 318161:SDEN_RS00610
uniprot id: Q12T11
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

318161:SDEN RS09745
gene id: 318161:SDEN_RS09745
uniprot id: Q12N27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

318161:SDEN RS18565
gene id: 318161:SDEN_RS18565
uniprot id: Q12I80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

318161:SDEN RS17745
gene id: 318161:SDEN_RS17745
uniprot id: Q12IN4
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS16405
gene id: 318161:SDEN_RS16405
uniprot id: Q12JE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmI family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.

318161:SDEN RS10310
gene id: 318161:SDEN_RS10310
uniprot id: Q12MR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

318161:SDEN RS05385
gene id: 318161:SDEN_RS05385
uniprot id: Q12QF3
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

318161:SDEN RS11575
gene id: 318161:SDEN_RS11575
uniprot id: Q12M17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Gram-negative porin family.
messages: Cell outer membrane
messages: Membrane

318161:SDEN RS17565
gene id: 318161:SDEN_RS17565
uniprot id: Q12IR8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 3 lipoyl cofactors covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

318161:SDEN RS10160
gene id: 318161:SDEN_RS10160
uniprot id: Q12MU6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS19570
gene id: 318161:SDEN_RS19570
uniprot id: Q12HP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

318161:SDEN RS07420
gene id: 318161:SDEN_RS07420
uniprot id: Q12PC2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS07740
gene id: 318161:SDEN_RS07740
uniprot id: Q12P63
names: Similarity
messages: Belongs to the Gfa family.

318161:SDEN RS13395
gene id: 318161:SDEN_RS13395
uniprot id: Q12L25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

318161:SDEN RS17135
gene id: 318161:SDEN_RS17135
uniprot id: Q12J03
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

318161:SDEN RS12380
gene id: 318161:SDEN_RS12380
uniprot id: Q12LL0
names: Similarity
messages: Belongs to the UPF0276 family.

318161:SDEN RS12715
gene id: 318161:SDEN_RS12715
uniprot id: Q12LE4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

318161:SDEN RS03385
gene id: 318161:SDEN_RS03385
uniprot id: Q12RI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS15220
gene id: 318161:SDEN_RS15220
uniprot id: Q12K19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

318161:SDEN RS01110
gene id: 318161:SDEN_RS01110
uniprot id: Q12SS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

318161:SDEN RS07995
gene id: 318161:SDEN_RS07995
uniprot id: Q12P11
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

318161:SDEN RS08990
gene id: 318161:SDEN_RS08990
uniprot id: Q12NG9
names: Similarity
messages: Belongs to the peptidase M1 family.

318161:SDEN RS09095
gene id: 318161:SDEN_RS09095
uniprot id: Q12NE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolA family.
messages: Monomer.
messages: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
messages: Periplasm

318161:SDEN RS12910
gene id: 318161:SDEN_RS12910
uniprot id: Q12LA4
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

318161:SDEN RS05130
gene id: 318161:SDEN_RS05130
uniprot id: Q12QK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

318161:SDEN RS00325
gene id: 318161:SDEN_RS00325
uniprot id: Q12T67
names: Similarity
messages: Belongs to the FliN/MopA/SpaO family.

318161:SDEN RS08425
gene id: 318161:SDEN_RS08425
uniprot id: Q12NS7
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: In the N-terminal section; belongs to the histidinol-phosphatase family.

318161:SDEN RS18295
gene id: 318161:SDEN_RS18295
uniprot id: Q12ID1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

318161:SDEN RS17980
gene id: 318161:SDEN_RS17980
uniprot id: Q12IJ3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

318161:SDEN RS09145
gene id: 318161:SDEN_RS09145
uniprot id: Q12ND8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

318161:SDEN RS14025
gene id: 318161:SDEN_RS14025
uniprot id: Q12KP9
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

318161:SDEN RS03830
gene id: 318161:SDEN_RS03830
uniprot id: Q12R98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS10695
gene id: 318161:SDEN_RS10695
uniprot id: Q12MJ3
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

318161:SDEN RS08450
gene id: 318161:SDEN_RS08450
uniprot id: Q12NS2
names: Similarity
messages: Belongs to the KAE1 / TsaD family. TsaB subfamily.

318161:SDEN RS18910
gene id: 318161:SDEN_RS18910
uniprot id: Q12I12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

318161:SDEN RS09760
gene id: 318161:SDEN_RS09760
uniprot id: Q12N24
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

318161:SDEN RS12490
gene id: 318161:SDEN_RS12490
uniprot id: Q12LJ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS09190
gene id: 318161:SDEN_RS09190
uniprot id: Q12NC8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

318161:SDEN RS03885
gene id: 318161:SDEN_RS03885
uniprot id: Q12R87
names: Similarity
messages: Belongs to the RecJ family.

318161:SDEN RS17180
gene id: 318161:SDEN_RS17180
uniprot id: Q12IZ4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

318161:SDEN RS07780
gene id: 318161:SDEN_RS07780
uniprot id: Q12P55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.

318161:SDEN RS00020
gene id: 318161:SDEN_RS00020
uniprot id: Q12TC5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

318161:SDEN RS08485
gene id: 318161:SDEN_RS08485
uniprot id: Q12NR5
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

318161:SDEN RS09465
gene id: 318161:SDEN_RS09465
uniprot id: Q12N77
names: Similarity
messages: Belongs to the ArsC family.

318161:SDEN RS16080
gene id: 318161:SDEN_RS16080
uniprot id: Q12JK6
names: Similarity
messages: Belongs to the peptidase S8 family.

318161:SDEN RS09915
gene id: 318161:SDEN_RS09915
uniprot id: Q12MZ3
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

318161:SDEN RS13575
gene id: 318161:SDEN_RS13575
uniprot id: Q12KY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
messages: Membrane

318161:SDEN RS11370
gene id: 318161:SDEN_RS11370
uniprot id: Q12M59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS03785
gene id: 318161:SDEN_RS03785
uniprot id: Q12RA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS08365
gene id: 318161:SDEN_RS08365
uniprot id: Q12NU0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

318161:SDEN RS16755
gene id: 318161:SDEN_RS16755
uniprot id: Q12J78
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-III family.

318161:SDEN RS06660
gene id: 318161:SDEN_RS06660
uniprot id: Q12PR2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

318161:SDEN RS13440
gene id: 318161:SDEN_RS13440
uniprot id: Q12L16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

318161:SDEN RS15115
gene id: 318161:SDEN_RS15115
uniprot id: Q12K39
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

318161:SDEN RS09975
gene id: 318161:SDEN_RS09975
uniprot id: Q12MY2
names: Similarity
messages: Belongs to the peptidase S9C family.

318161:SDEN RS15770
gene id: 318161:SDEN_RS15770
uniprot id: Q12JR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

318161:SDEN RS06270
gene id: 318161:SDEN_RS06270
uniprot id: Q12PY3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

318161:SDEN RS10305
gene id: 318161:SDEN_RS10305
uniprot id: Q12MR7
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS04615
gene id: 318161:SDEN_RS04615
uniprot id: Q12QV2
names: Similarity
messages: Belongs to the DEAD box helicase family.

318161:SDEN RS13475
gene id: 318161:SDEN_RS13475
uniprot id: Q12L09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.

318161:SDEN RS10510
gene id: 318161:SDEN_RS10510
uniprot id: Q12MM9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS14640
gene id: 318161:SDEN_RS14640
uniprot id: Q12KC9
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

318161:SDEN RS16630
gene id: 318161:SDEN_RS16630
uniprot id: Q12JA0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

318161:SDEN RS01540
gene id: 318161:SDEN_RS01540
uniprot id: Q12SJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapB family.
messages: Cytoplasm
messages: Homodimer. The ends of the coiled-coil dimer bind to each other, forming polymers. Interacts with FtsZ.
messages: Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.

318161:SDEN RS02660
gene id: 318161:SDEN_RS02660
uniprot id: Q12RX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

318161:SDEN RS14920
gene id: 318161:SDEN_RS14920
uniprot id: Q12K79
names: Similarity
messages: Belongs to the peptidase S8 family.

318161:SDEN RS09865
gene id: 318161:SDEN_RS09865
uniprot id: Q12N03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
messages: Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
messages: Homotetramer.

318161:SDEN RS03030
gene id: 318161:SDEN_RS03030
uniprot id: Q12RQ8
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

318161:SDEN RS13450
gene id: 318161:SDEN_RS13450
uniprot id: Q12L14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS13945
gene id: 318161:SDEN_RS13945
uniprot id: Q12KR5
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

318161:SDEN RS02685
gene id: 318161:SDEN_RS02685
uniprot id: Q12RX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

318161:SDEN RS18745
gene id: 318161:SDEN_RS18745
uniprot id: Q12I45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

318161:SDEN RS14365
gene id: 318161:SDEN_RS14365
uniprot id: Q12KI3
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

318161:SDEN RS04630
gene id: 318161:SDEN_RS04630
uniprot id: Q12QU9
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

318161:SDEN RS15535
gene id: 318161:SDEN_RS15535
uniprot id: Q12JW1
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS19530
gene id: 318161:SDEN_RS19530
uniprot id: Q12HP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

318161:SDEN RS12520
gene id: 318161:SDEN_RS12520
uniprot id: Q12LI4
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS15210
gene id: 318161:SDEN_RS15210
uniprot id: Q12K21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

318161:SDEN RS06430
gene id: 318161:SDEN_RS06430
uniprot id: Q12PV7
names: Similarity
messages: Belongs to the YjdM family.

318161:SDEN RS00945
gene id: 318161:SDEN_RS00945
uniprot id: Q12SV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

318161:SDEN RS00245
gene id: 318161:SDEN_RS00245
uniprot id: Q12T83
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

318161:SDEN RS19355
gene id: 318161:SDEN_RS19355
uniprot id: Q12HT3
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

318161:SDEN RS02665
gene id: 318161:SDEN_RS02665
uniprot id: Q12RX7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

318161:SDEN RS10125
gene id: 318161:SDEN_RS10125
uniprot id: Q12MV3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

318161:SDEN RS12450
gene id: 318161:SDEN_RS12450
uniprot id: Q12LJ8
names: Cofactor
names: Similarity
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.

318161:SDEN RS01375
gene id: 318161:SDEN_RS01375
uniprot id: Q12SM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

318161:SDEN RS01050
gene id: 318161:SDEN_RS01050
uniprot id: Q12ST2
names: Subcellular Location Annotation
messages: Secreted

318161:SDEN RS11625
gene id: 318161:SDEN_RS11625
uniprot id: Q12M07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

318161:SDEN RS14455
gene id: 318161:SDEN_RS14455
uniprot id: Q12KG5
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

318161:SDEN RS08685
gene id: 318161:SDEN_RS08685
uniprot id: Q12NM6
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

318161:SDEN RS05180
gene id: 318161:SDEN_RS05180
uniprot id: Q12QJ2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS06980
gene id: 318161:SDEN_RS06980
uniprot id: Q12PJ9
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

318161:SDEN RS09100
gene id: 318161:SDEN_RS09100
uniprot id: Q12NE7
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

318161:SDEN RS14715
gene id: 318161:SDEN_RS14715
uniprot id: Q12KB4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

318161:SDEN RS18815
gene id: 318161:SDEN_RS18815
uniprot id: Q12I31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

318161:SDEN RS11910
gene id: 318161:SDEN_RS11910
uniprot id: Q12LV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

318161:SDEN RS10900
gene id: 318161:SDEN_RS10900
uniprot id: Q12MF2
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS15650
gene id: 318161:SDEN_RS15650
uniprot id: Q12JT8
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

318161:SDEN RS19560
gene id: 318161:SDEN_RS19560
uniprot id: Q12HP3
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

318161:SDEN RS17930
gene id: 318161:SDEN_RS17930
uniprot id: Q12IK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0761 family.
messages: Cell inner membrane

318161:SDEN RS00960
gene id: 318161:SDEN_RS00960
uniprot id: Q12SV1
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

318161:SDEN RS01300
gene id: 318161:SDEN_RS01300
uniprot id: Q12SP0
names: Similarity
messages: Belongs to the thioesterase family.

318161:SDEN RS03550
gene id: 318161:SDEN_RS03550
uniprot id: Q12RF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

318161:SDEN RS09220
gene id: 318161:SDEN_RS09220
uniprot id: Q12NC2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

318161:SDEN RS13880
gene id: 318161:SDEN_RS13880
uniprot id: Q12KS8
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS09840
gene id: 318161:SDEN_RS09840
uniprot id: Q12N08
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

318161:SDEN RS12840
gene id: 318161:SDEN_RS12840
uniprot id: Q12LB8
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS05340
gene id: 318161:SDEN_RS05340
uniprot id: Q12QG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.
messages: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

318161:SDEN RS01940
gene id: 318161:SDEN_RS01940
uniprot id: Q12SB7
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

318161:SDEN RS07845
gene id: 318161:SDEN_RS07845
uniprot id: Q12P42
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NapC/NirT/NrfH family.
messages: Binds 4 heme groups per subunit.
messages: Membrane

318161:SDEN RS16665
gene id: 318161:SDEN_RS16665
uniprot id: Q12J93
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

318161:SDEN RS08745
gene id: 318161:SDEN_RS08745
uniprot id: Q12NL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

318161:SDEN RS09555
gene id: 318161:SDEN_RS09555
uniprot id: Q12N59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

318161:SDEN RS05210
gene id: 318161:SDEN_RS05210
uniprot id: Q12QI6
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

318161:SDEN RS09395
gene id: 318161:SDEN_RS09395
uniprot id: Q12N90
names: Function
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.

318161:SDEN RS04125
gene id: 318161:SDEN_RS04125
uniprot id: Q12R39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

318161:SDEN RS17285
gene id: 318161:SDEN_RS17285
uniprot id: Q12IX3
names: Similarity
messages: Belongs to the peptidase U62 family.

318161:SDEN RS13510
gene id: 318161:SDEN_RS13510
uniprot id: Q12L02
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

318161:SDEN RS11380
gene id: 318161:SDEN_RS11380
uniprot id: Q12M57
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.
messages: The heme is bound between the two transmembrane subunits.

318161:SDEN RS05150
gene id: 318161:SDEN_RS05150
uniprot id: Q12QJ8
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

318161:SDEN RS14215
gene id: 318161:SDEN_RS14215
uniprot id: Q12KL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

318161:SDEN RS07280
gene id: 318161:SDEN_RS07280
uniprot id: Q12PE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

318161:SDEN RS01150
gene id: 318161:SDEN_RS01150
uniprot id: Q12SR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

318161:SDEN RS15985
gene id: 318161:SDEN_RS15985
uniprot id: Q12JM5
names: Similarity
messages: Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family.

318161:SDEN RS14310
gene id: 318161:SDEN_RS14310
uniprot id: Q12KJ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

318161:SDEN RS09620
gene id: 318161:SDEN_RS09620
uniprot id: Q12N46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

318161:SDEN RS01445
gene id: 318161:SDEN_RS01445
uniprot id: Q12SL2
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

318161:SDEN RS04090
gene id: 318161:SDEN_RS04090
uniprot id: Q12R46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS07640
gene id: 318161:SDEN_RS07640
uniprot id: Q12P82
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

318161:SDEN RS07685
gene id: 318161:SDEN_RS07685
uniprot id: Q12P73
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

318161:SDEN RS07465
gene id: 318161:SDEN_RS07465
uniprot id: Q12PB3
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

318161:SDEN RS02140
gene id: 318161:SDEN_RS02140
uniprot id: Q12S77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. UvrD subfamily.
messages: Homodimer.
messages: Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.

318161:SDEN RS14200
gene id: 318161:SDEN_RS14200
uniprot id: Q12KL6
names: Similarity
messages: Belongs to the XFP family.

318161:SDEN RS07955
gene id: 318161:SDEN_RS07955
uniprot id: Q12P19
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

318161:SDEN RS16465
gene id: 318161:SDEN_RS16465
uniprot id: Q12JD3
names: Caution
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS11920
gene id: 318161:SDEN_RS11920
uniprot id: Q12LU8
names: Function
names: Similarity
messages: Belongs to the DUF177 domain family.
messages: Plays a role in synthesis, processing and/or stability of 23S rRNA.

318161:SDEN RS10705
gene id: 318161:SDEN_RS10705
uniprot id: Q12MJ1
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

318161:SDEN RS07010
gene id: 318161:SDEN_RS07010
uniprot id: Q12PJ3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

318161:SDEN RS18570
gene id: 318161:SDEN_RS18570
uniprot id: Q12I79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmD/CycX/HelD family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

318161:SDEN RS13965
gene id: 318161:SDEN_RS13965
uniprot id: Q12KR1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

318161:SDEN RS12955
gene id: 318161:SDEN_RS12955
uniprot id: Q12L98
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

318161:SDEN RS13345
gene id: 318161:SDEN_RS13345
uniprot id: Q12L35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
messages: Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
messages: Cytoplasm
messages: Monomer.

318161:SDEN RS07250
gene id: 318161:SDEN_RS07250
uniprot id: Q12PF0
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

318161:SDEN RS10480
gene id: 318161:SDEN_RS10480
uniprot id: Q12MN2
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

318161:SDEN RS06470
gene id: 318161:SDEN_RS06470
uniprot id: Q12PU9
names: Similarity
messages: Belongs to the UPF0125 (RnfH) family.

318161:SDEN RS05250
gene id: 318161:SDEN_RS05250
uniprot id: Q12QI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

318161:SDEN RS15215
gene id: 318161:SDEN_RS15215
uniprot id: Q12K20
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

318161:SDEN RS06795
gene id: 318161:SDEN_RS06795
uniprot id: Q12PN6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

318161:SDEN RS11565
gene id: 318161:SDEN_RS11565
uniprot id: Q12M19
names: Similarity
messages: Belongs to the peptidase S33 family.

318161:SDEN RS05690
gene id: 318161:SDEN_RS05690
uniprot id: Q12Q96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

318161:SDEN RS04640
gene id: 318161:SDEN_RS04640
uniprot id: Q12QU7
names: Similarity
messages: Belongs to the DEAD box helicase family.

318161:SDEN RS16470
gene id: 318161:SDEN_RS16470
uniprot id: Q12JD2
names: Similarity
messages: Belongs to the peptidase M17 family.

318161:SDEN RS16240
gene id: 318161:SDEN_RS16240
uniprot id: Q12JH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS07150
gene id: 318161:SDEN_RS07150
uniprot id: Q12PG5
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

318161:SDEN RS11375
gene id: 318161:SDEN_RS11375
uniprot id: Q12M58
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.
messages: The heme is bound between the two transmembrane subunits.

318161:SDEN RS07000
gene id: 318161:SDEN_RS07000
uniprot id: Q12PJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CheZ family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).

318161:SDEN RS18120
gene id: 318161:SDEN_RS18120
uniprot id: Q12IG5
names: Similarity
messages: Belongs to the peptidase M16 family.

318161:SDEN RS07655
gene id: 318161:SDEN_RS07655
uniprot id: Q12P79
names: Function
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.

318161:SDEN RS18995
gene id: 318161:SDEN_RS18995
uniprot id: Q12HZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cytoplasm

318161:SDEN RS15125
gene id: 318161:SDEN_RS15125
uniprot id: Q12K37
names: Similarity
messages: Belongs to the SlyX family.

318161:SDEN RS02210
gene id: 318161:SDEN_RS02210
uniprot id: Q12S67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.

318161:SDEN RS06705
gene id: 318161:SDEN_RS06705
uniprot id: Q12PQ3
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

318161:SDEN RS05135
gene id: 318161:SDEN_RS05135
uniprot id: Q12QK1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrF family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

318161:SDEN RS10190
gene id: 318161:SDEN_RS10190
uniprot id: Q12MU0
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

318161:SDEN RS06765
gene id: 318161:SDEN_RS06765
uniprot id: Q12PP2
names: Function
names: Similarity
messages: Belongs to the FlgN family.
messages: Required for the efficient initiation of filament assembly.

318161:SDEN RS03190
gene id: 318161:SDEN_RS03190
uniprot id: Q12RM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS07650
gene id: 318161:SDEN_RS07650
uniprot id: Q12P80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HscB family.
messages: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.
messages: Interacts with HscA and stimulates its ATPase activity.

318161:SDEN RS18080
gene id: 318161:SDEN_RS18080
uniprot id: Q12IH3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

318161:SDEN RS17615
gene id: 318161:SDEN_RS17615
uniprot id: Q12IQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

318161:SDEN RS00540
gene id: 318161:SDEN_RS00540
uniprot id: Q12T25
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

318161:SDEN RS00900
gene id: 318161:SDEN_RS00900
uniprot id: Q12SW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

318161:SDEN RS06065
gene id: 318161:SDEN_RS06065
uniprot id: Q12Q25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.
messages: Homodimer.
messages: Involved in phosphonate degradation.

318161:SDEN RS13070
gene id: 318161:SDEN_RS13070
uniprot id: Q12L75
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family. L-methionine gamma-lyase subfamily.

318161:SDEN RS12795
gene id: 318161:SDEN_RS12795
uniprot id: Q12LC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

318161:SDEN RS10910
gene id: 318161:SDEN_RS10910
uniprot id: Q12MF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

318161:SDEN RS15690
gene id: 318161:SDEN_RS15690
uniprot id: Q12JT1
names: Function
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

318161:SDEN RS13325
gene id: 318161:SDEN_RS13325
uniprot id: Q12L39
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Xni family.
messages: Binds 1 K(+) per subunit. The potassium ion strongly increases the affinity for DNA.
messages: Binds 2 Mg(2+) per subunit. Only one magnesium ion has a direct interaction with the protein, the other interactions are indirect.
messages: Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.

318161:SDEN RS09150
gene id: 318161:SDEN_RS09150
uniprot id: Q12ND7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapA family.
messages: Cell inner membrane
messages: Involved in the assembly of lipopolysaccharide (LPS).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS12805
gene id: 318161:SDEN_RS12805
uniprot id: Q12LC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmKL family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.

318161:SDEN RS05650
gene id: 318161:SDEN_RS05650
uniprot id: Q12QA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
messages: Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
messages: Cytoplasm
messages: Homotetramer.

318161:SDEN RS08010
gene id: 318161:SDEN_RS08010
uniprot id: Q12P08
names: Function
names: Similarity
messages: Belongs to the peptidase M16 family.
messages: Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin.

318161:SDEN RS01830
gene id: 318161:SDEN_RS01830
uniprot id: Q12SD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

318161:SDEN RS19540
gene id: 318161:SDEN_RS19540
uniprot id: Q12HP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

318161:SDEN RS10150
gene id: 318161:SDEN_RS10150
uniprot id: Q12MU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
messages: Cytoplasm
messages: Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.

318161:SDEN RS14295
gene id: 318161:SDEN_RS14295
uniprot id: Q12KJ7
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

318161:SDEN RS08680
gene id: 318161:SDEN_RS08680
uniprot id: Q12NM7
names: Similarity
messages: Belongs to the citrate synthase family.

318161:SDEN RS14600
gene id: 318161:SDEN_RS14600
uniprot id: Q12KD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS12920
gene id: 318161:SDEN_RS12920
uniprot id: Q12LA2
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

318161:SDEN RS12870
gene id: 318161:SDEN_RS12870
uniprot id: Q12LB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

318161:SDEN RS04160
gene id: 318161:SDEN_RS04160
uniprot id: Q12R32
names: Similarity
messages: Belongs to the peptidase A1 family.

318161:SDEN RS07155
gene id: 318161:SDEN_RS07155
uniprot id: Q12PG4
names: Similarity
messages: Belongs to the TPP enzyme family.

318161:SDEN RS01035
gene id: 318161:SDEN_RS01035
uniprot id: Q12ST5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

318161:SDEN RS15200
gene id: 318161:SDEN_RS15200
uniprot id: Q12K23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

318161:SDEN RS18690
gene id: 318161:SDEN_RS18690
uniprot id: Q12I56
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

318161:SDEN RS08135
gene id: 318161:SDEN_RS08135
uniprot id: Q12NY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

318161:SDEN RS00975
gene id: 318161:SDEN_RS00975
uniprot id: Q12SU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

318161:SDEN RS02580
gene id: 318161:SDEN_RS02580
uniprot id: Q12RZ4
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.

318161:SDEN RS05685
gene id: 318161:SDEN_RS05685
uniprot id: Q12Q97
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

318161:SDEN RS08495
gene id: 318161:SDEN_RS08495
uniprot id: Q12NR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

318161:SDEN RS17720
gene id: 318161:SDEN_RS17720
uniprot id: Q12IN9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

318161:SDEN RS08930
gene id: 318161:SDEN_RS08930
uniprot id: Q12NI1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

318161:SDEN RS04305
gene id: 318161:SDEN_RS04305
uniprot id: Q12R11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.
messages: Homodimer.

318161:SDEN RS05730
gene id: 318161:SDEN_RS05730
uniprot id: Q12Q88
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS09420
gene id: 318161:SDEN_RS09420
uniprot id: Q12N85
names: Similarity
messages: Belongs to the DsrF/TusC family.

318161:SDEN RS13385
gene id: 318161:SDEN_RS13385
uniprot id: Q12L27
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

318161:SDEN RS15965
gene id: 318161:SDEN_RS15965
uniprot id: Q12JM9
names: Similarity
messages: Belongs to the intimin/invasin family.

318161:SDEN RS01000
gene id: 318161:SDEN_RS01000
uniprot id: Q12SU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

318161:SDEN RS17320
gene id: 318161:SDEN_RS17320
uniprot id: Q12IW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

318161:SDEN RS09110
gene id: 318161:SDEN_RS09110
uniprot id: Q12NE5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

318161:SDEN RS06810
gene id: 318161:SDEN_RS06810
uniprot id: Q12PN3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

318161:SDEN RS05935
gene id: 318161:SDEN_RS05935
uniprot id: Q12Q48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS13505
gene id: 318161:SDEN_RS13505
uniprot id: Q12L03
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

318161:SDEN RS12075
gene id: 318161:SDEN_RS12075
uniprot id: Q12LR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinylarginine dihydrolase family.
messages: Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
messages: Homodimer.

318161:SDEN RS08750
gene id: 318161:SDEN_RS08750
uniprot id: Q12NL3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.

318161:SDEN RS10820
gene id: 318161:SDEN_RS10820
uniprot id: Q12MG7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.

318161:SDEN RS12355
gene id: 318161:SDEN_RS12355
uniprot id: Q12LL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

318161:SDEN RS00520
gene id: 318161:SDEN_RS00520
uniprot id: Q12T29
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

318161:SDEN RS11100
gene id: 318161:SDEN_RS11100
uniprot id: Q12MB2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

318161:SDEN RS13460
gene id: 318161:SDEN_RS13460
uniprot id: Q12L12
names: Subcellular Location Annotation
messages: Cytoplasm

318161:SDEN RS15145
gene id: 318161:SDEN_RS15145
uniprot id: Q12K33
names: Similarity
messages: Belongs to the peptidase M1 family.

318161:SDEN RS12565
gene id: 318161:SDEN_RS12565
uniprot id: Q12LH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.

318161:SDEN RS14875
gene id: 318161:SDEN_RS14875
uniprot id: Q12K86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

318161:SDEN RS18535
gene id: 318161:SDEN_RS18535
uniprot id: Q12I86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbE subfamily.
messages: Cell inner membrane

318161:SDEN RS14685
gene id: 318161:SDEN_RS14685
uniprot id: Q12KC0
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

318161:SDEN RS06005
gene id: 318161:SDEN_RS06005
uniprot id: Q12Q34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 51 family.
messages: Cell inner membrane
messages: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.

318161:SDEN RS07520
gene id: 318161:SDEN_RS07520
uniprot id: Q12PA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

318161:SDEN RS06135
gene id: 318161:SDEN_RS06135
uniprot id: Q12Q10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

318161:SDEN RS06630
gene id: 318161:SDEN_RS06630
uniprot id: Q12PR8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: In the C-terminal section; belongs to the transglycosylase Slt family.
messages: In the N-terminal section; belongs to the bacterial solute-binding protein 3 family.
messages: Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
messages: The N-terminal domain does not have lytic activity and probably modulates enzymatic activity. The C-terminal domain is the catalytic active domain.

318161:SDEN RS09995
gene id: 318161:SDEN_RS09995
uniprot id: Q12MX8
names: Similarity
messages: Belongs to the ice-binding protein family.

318161:SDEN RS01875
gene id: 318161:SDEN_RS01875
uniprot id: Q12SC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

318161:SDEN RS18945
gene id: 318161:SDEN_RS18945
uniprot id: Q12I05
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

318161:SDEN RS14405
gene id: 318161:SDEN_RS14405
uniprot id: Q12KH5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

318161:SDEN RS19780
gene id: 318161:SDEN_RS19780
uniprot id: Q12P37
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS04355
gene id: 318161:SDEN_RS04355
uniprot id: Q12R01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

318161:SDEN RS06400
gene id: 318161:SDEN_RS06400
uniprot id: Q12PW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

318161:SDEN RS05050
gene id: 318161:SDEN_RS05050
uniprot id: Q12QL8
names: Function
messages: May be involved in the biogenesis of curli organelles.

318161:SDEN RS18790
gene id: 318161:SDEN_RS18790
uniprot id: Q12I36
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.

318161:SDEN RS19015
gene id: 318161:SDEN_RS19015
uniprot id: Q12HZ1
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

318161:SDEN RS07615
gene id: 318161:SDEN_RS07615
uniprot id: Q12P87
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

318161:SDEN RS07270
gene id: 318161:SDEN_RS07270
uniprot id: Q12PE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TolB family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: Periplasm
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

318161:SDEN RS07875
gene id: 318161:SDEN_RS07875
uniprot id: Q12P36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TamA family.
messages: Cell outer membrane
messages: Membrane

318161:SDEN RS14700
gene id: 318161:SDEN_RS14700
uniprot id: Q12KB7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

318161:SDEN RS06225
gene id: 318161:SDEN_RS06225
uniprot id: Q12PZ2
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

318161:SDEN RS08555
gene id: 318161:SDEN_RS08555
uniprot id: Q12NQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

318161:SDEN RS17570
gene id: 318161:SDEN_RS17570
uniprot id: Q12IR7
names: Function
names: Subunit
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
messages: Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

318161:SDEN RS11980
gene id: 318161:SDEN_RS11980
uniprot id: Q12LT6
names: Similarity
messages: Belongs to the UPF0438 family.

318161:SDEN RS08090
gene id: 318161:SDEN_RS08090
uniprot id: Q12NZ3
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS18305
gene id: 318161:SDEN_RS18305
uniprot id: Q12ID0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

318161:SDEN RS02710
gene id: 318161:SDEN_RS02710
uniprot id: Q12RW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PriB family.
messages: Binds single-stranded DNA at the primosome assembly site (PAS).
messages: Component of the preprimosomal complex composed of PriA, PriB, PriC, DnaB and DnaT. Upon transient interaction with DnaG it forms the primosome.

318161:SDEN RS10140
gene id: 318161:SDEN_RS10140
uniprot id: Q12MV0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

318161:SDEN RS14185
gene id: 318161:SDEN_RS14185
uniprot id: Q12KL9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Lysosome
messages: Secreted

318161:SDEN RS11360
gene id: 318161:SDEN_RS11360
uniprot id: Q12M61
names: Function
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

318161:SDEN RS09550
gene id: 318161:SDEN_RS09550
uniprot id: Q12N60
names: Subcellular Location Annotation
messages: Cytoplasm

318161:SDEN RS12850
gene id: 318161:SDEN_RS12850
uniprot id: Q12LB6
names: Similarity
messages: Belongs to the PspA/IM30 family.

318161:SDEN RS01690
gene id: 318161:SDEN_RS01690
uniprot id: Q12SG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

318161:SDEN RS06195
gene id: 318161:SDEN_RS06195
uniprot id: Q12PZ8
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.

318161:SDEN RS15035
gene id: 318161:SDEN_RS15035
uniprot id: Q12K56
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

318161:SDEN RS17610
gene id: 318161:SDEN_RS17610
uniprot id: Q12IQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

318161:SDEN RS09090
gene id: 318161:SDEN_RS09090
uniprot id: Q12NE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

318161:SDEN RS10130
gene id: 318161:SDEN_RS10130
uniprot id: Q12MV2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

318161:SDEN RS02435
gene id: 318161:SDEN_RS02435
uniprot id: Q12S22
names: Similarity
messages: Belongs to the arginase family.

318161:SDEN RS18170
gene id: 318161:SDEN_RS18170
uniprot id: Q12IF6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS03880
gene id: 318161:SDEN_RS03880
uniprot id: Q12R88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.

318161:SDEN RS13570
gene id: 318161:SDEN_RS13570
uniprot id: Q12KZ0
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

318161:SDEN RS02785
gene id: 318161:SDEN_RS02785
uniprot id: Q12RV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RraB family.
messages: Cytoplasm
messages: Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
messages: Interacts with the C-terminal region of Rne.

318161:SDEN RS11250
gene id: 318161:SDEN_RS11250
uniprot id: Q12M83
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS09405
gene id: 318161:SDEN_RS09405
uniprot id: Q12N88
names: Similarity
messages: Belongs to the YciI family.

318161:SDEN RS07830
gene id: 318161:SDEN_RS07830
uniprot id: Q12P45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapD family.
messages: Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

318161:SDEN RS08705
gene id: 318161:SDEN_RS08705
uniprot id: Q12NM2
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

318161:SDEN RS18575
gene id: 318161:SDEN_RS18575
uniprot id: Q12I78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell inner membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

318161:SDEN RS19050
gene id: 318161:SDEN_RS19050
uniprot id: Q12HY4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

318161:SDEN RS03425
gene id: 318161:SDEN_RS03425
uniprot id: Q12RH8
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

318161:SDEN RS04835
gene id: 318161:SDEN_RS04835
uniprot id: Q12QQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Heterodimer of an alpha and a beta chain.
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

318161:SDEN RS07910
gene id: 318161:SDEN_RS07910
uniprot id: Q12P28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS11045
gene id: 318161:SDEN_RS11045
uniprot id: Q12MC3
names: Similarity
messages: Belongs to the UPF0381 family.

318161:SDEN RS08165
gene id: 318161:SDEN_RS08165
uniprot id: Q12NX8
names: Similarity
messages: Belongs to the skp family.

318161:SDEN RS14380
gene id: 318161:SDEN_RS14380
uniprot id: Q12KI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

318161:SDEN RS08160
gene id: 318161:SDEN_RS08160
uniprot id: Q12NX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

318161:SDEN RS14960
gene id: 318161:SDEN_RS14960
uniprot id: Q12K71
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

318161:SDEN RS04470
gene id: 318161:SDEN_RS04470
uniprot id: Q12QY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

318161:SDEN RS13520
gene id: 318161:SDEN_RS13520
uniprot id: Q12L00
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

318161:SDEN RS06255
gene id: 318161:SDEN_RS06255
uniprot id: Q12PY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoS subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.

318161:SDEN RS04710
gene id: 318161:SDEN_RS04710
uniprot id: Q12QT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

318161:SDEN RS02905
gene id: 318161:SDEN_RS02905
uniprot id: Q12RT3
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

318161:SDEN RS08200
gene id: 318161:SDEN_RS08200
uniprot id: Q12NX1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

318161:SDEN RS06645
gene id: 318161:SDEN_RS06645
uniprot id: Q12PR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

318161:SDEN RS00940
gene id: 318161:SDEN_RS00940
uniprot id: Q12SV5
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

318161:SDEN RS06815
gene id: 318161:SDEN_RS06815
uniprot id: Q12PN2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

318161:SDEN RS06890
gene id: 318161:SDEN_RS06890
uniprot id: Q12PL7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

318161:SDEN RS03990
gene id: 318161:SDEN_RS03990
uniprot id: Q12R66
names: Similarity
names: Subunit
messages: Belongs to the UPF0234 family.
messages: Monomer.

318161:SDEN RS05645
gene id: 318161:SDEN_RS05645
uniprot id: Q12QA5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

318161:SDEN RS04330
gene id: 318161:SDEN_RS04330
uniprot id: Q12R06
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

318161:SDEN RS03805
gene id: 318161:SDEN_RS03805
uniprot id: Q12RA3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

318161:SDEN RS01360
gene id: 318161:SDEN_RS01360
uniprot id: Q12SM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

318161:SDEN RS06870
gene id: 318161:SDEN_RS06870
uniprot id: Q12PM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

318161:SDEN RS10325
gene id: 318161:SDEN_RS10325
uniprot id: Q12MR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

318161:SDEN RS17075
gene id: 318161:SDEN_RS17075
uniprot id: Q12J15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

318161:SDEN RS02605
gene id: 318161:SDEN_RS02605
uniprot id: Q12RY9
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS02715
gene id: 318161:SDEN_RS02715
uniprot id: Q12RW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

318161:SDEN RS16650
gene id: 318161:SDEN_RS16650
uniprot id: Q12J96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

318161:SDEN RS09050
gene id: 318161:SDEN_RS09050
uniprot id: Q12NF7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

318161:SDEN RS06230
gene id: 318161:SDEN_RS06230
uniprot id: Q12PZ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

318161:SDEN RS14300
gene id: 318161:SDEN_RS14300
uniprot id: Q12KJ6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

318161:SDEN RS00025
gene id: 318161:SDEN_RS00025
uniprot id: Q12TC4
names: Cofactor
names: PTM
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.

318161:SDEN RS02600
gene id: 318161:SDEN_RS02600
uniprot id: Q12RZ0
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

318161:SDEN RS17850
gene id: 318161:SDEN_RS17850
uniprot id: Q12IL3
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS18540
gene id: 318161:SDEN_RS18540
uniprot id: Q12I85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS12600
gene id: 318161:SDEN_RS12600
uniprot id: Q12LG7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the helicase family. DinG subfamily. Type 1 sub-subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA-dependent ATPase and 5'-3' DNA helicase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS07850
gene id: 318161:SDEN_RS07850
uniprot id: Q12P41
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

318161:SDEN RS09735
gene id: 318161:SDEN_RS09735
uniprot id: Q12N29
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

318161:SDEN RS10185
gene id: 318161:SDEN_RS10185
uniprot id: Q12MU1
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

318161:SDEN RS00040
gene id: 318161:SDEN_RS00040
uniprot id: Q12TC1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

318161:SDEN RS04995
gene id: 318161:SDEN_RS04995
uniprot id: Q12QM7
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS19345
gene id: 318161:SDEN_RS19345
uniprot id: Q12HT5
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.

318161:SDEN RS17420
gene id: 318161:SDEN_RS17420
uniprot id: Q12IU6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

318161:SDEN RS02800
gene id: 318161:SDEN_RS02800
uniprot id: Q12RV0
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

318161:SDEN RS03970
gene id: 318161:SDEN_RS03970
uniprot id: Q12R70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

318161:SDEN RS13840
gene id: 318161:SDEN_RS13840
uniprot id: Q12KT6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

318161:SDEN RS19840
gene id: 318161:SDEN_RS19840
uniprot id: Q12M88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

318161:SDEN RS15010
gene id: 318161:SDEN_RS15010
uniprot id: Q12K61
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

318161:SDEN RS01545
gene id: 318161:SDEN_RS01545
uniprot id: Q12SJ2
names: Similarity
messages: Belongs to the RutC family.

318161:SDEN RS16430
gene id: 318161:SDEN_RS16430
uniprot id: Q12JE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

318161:SDEN RS18875
gene id: 318161:SDEN_RS18875
uniprot id: Q12I19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

318161:SDEN RS14375
gene id: 318161:SDEN_RS14375
uniprot id: Q12KI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

318161:SDEN RS10385
gene id: 318161:SDEN_RS10385
uniprot id: Q12MQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

318161:SDEN RS05245
gene id: 318161:SDEN_RS05245
uniprot id: Q12QI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

318161:SDEN RS04060
gene id: 318161:SDEN_RS04060
uniprot id: Q12R52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (HmuV), two transmembrane proteins (HmuU) and a solute-binding protein (HmuT).

318161:SDEN RS06900
gene id: 318161:SDEN_RS06900
uniprot id: Q12PL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

318161:SDEN RS09105
gene id: 318161:SDEN_RS09105
uniprot id: Q12NE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

318161:SDEN RS10470
gene id: 318161:SDEN_RS10470
uniprot id: Q12MN4
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

318161:SDEN RS02215
gene id: 318161:SDEN_RS02215
uniprot id: Q12S66
names: Similarity
messages: Belongs to the CutA family.

318161:SDEN RS13565
gene id: 318161:SDEN_RS13565
uniprot id: Q12KZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.
messages: Membrane

318161:SDEN RS19595
gene id: 318161:SDEN_RS19595
uniprot id: Q12HN6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

318161:SDEN RS10545
gene id: 318161:SDEN_RS10545
uniprot id: Q12MM2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Monomer.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

318161:SDEN RS03315
gene id: 318161:SDEN_RS03315
uniprot id: Q12RK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the P-Pant transferase superfamily. EntD family.
messages: EntB, EntD, EntE, and EntF form a multienzyme complex called enterobactin synthase.
messages: Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. Plays an essential role in the assembly of the enterobactin by catalyzing the transfer of the 4'-phosphopantetheine (Ppant) moiety from coenzyme A to the apo-domains of both EntB (ArCP domain) and EntF (PCP domain) to yield their holo-forms which make them competent for the activation of 2,3-dihydroxybenzoate (DHB) and L-serine, respectively.

318161:SDEN RS16735
gene id: 318161:SDEN_RS16735
uniprot id: Q12J82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

318161:SDEN RS12460
gene id: 318161:SDEN_RS12460
uniprot id: Q12LJ6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Binds two Mg(2+) per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

318161:SDEN RS17305
gene id: 318161:SDEN_RS17305
uniprot id: Q12IW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

318161:SDEN RS03560
gene id: 318161:SDEN_RS03560
uniprot id: Q12RF2
names: Function
names: Similarity
messages: Belongs to the peptidase S46 family.
messages: Catalyzes the removal of dipeptides from the N-terminus of oligopeptides.

318161:SDEN RS03575
gene id: 318161:SDEN_RS03575
uniprot id: Q12RE9
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS18325
gene id: 318161:SDEN_RS18325
uniprot id: Q12IC6
names: Similarity
messages: Belongs to the SCO1/2 family.

318161:SDEN RS10055
gene id: 318161:SDEN_RS10055
uniprot id: Q12MW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBS4 family.
messages: Membrane
messages: centrosome
messages: cilium membrane

318161:SDEN RS19525
gene id: 318161:SDEN_RS19525
uniprot id: Q12HQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

318161:SDEN RS18970
gene id: 318161:SDEN_RS18970
uniprot id: Q12I00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

318161:SDEN RS00995
gene id: 318161:SDEN_RS00995
uniprot id: Q12SU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

318161:SDEN RS02720
gene id: 318161:SDEN_RS02720
uniprot id: Q12RW6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

318161:SDEN RS18825
gene id: 318161:SDEN_RS18825
uniprot id: Q12I29
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

318161:SDEN RS00800
gene id: 318161:SDEN_RS00800
uniprot id: Q12SY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

318161:SDEN RS04765
gene id: 318161:SDEN_RS04765
uniprot id: Q12QS2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

318161:SDEN RS10680
gene id: 318161:SDEN_RS10680
uniprot id: Q12MJ6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

318161:SDEN RS07430
gene id: 318161:SDEN_RS07430
uniprot id: Q12PC0
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

318161:SDEN RS04240
gene id: 318161:SDEN_RS04240
uniprot id: Q12R18
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

318161:SDEN RS03220
gene id: 318161:SDEN_RS03220
uniprot id: Q12RM1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

318161:SDEN RS15530
gene id: 318161:SDEN_RS15530
uniprot id: Q12JW2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

318161:SDEN RS05080
gene id: 318161:SDEN_RS05080
uniprot id: Q12QL2
names: Similarity
messages: Belongs to the universal stress protein A family.

318161:SDEN RS06640
gene id: 318161:SDEN_RS06640
uniprot id: Q12PR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS00430
gene id: 318161:SDEN_RS00430
uniprot id: Q12T46
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm

318161:SDEN RS14305
gene id: 318161:SDEN_RS14305
uniprot id: Q12KJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

318161:SDEN RS14865
gene id: 318161:SDEN_RS14865
uniprot id: Q12K88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

318161:SDEN RS08335
gene id: 318161:SDEN_RS08335
uniprot id: Q12NU6
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

318161:SDEN RS05100
gene id: 318161:SDEN_RS05100
uniprot id: Q12QK8
names: Similarity
messages: Belongs to the BolA/IbaG family.

318161:SDEN RS02550
gene id: 318161:SDEN_RS02550
uniprot id: Q12S00
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

318161:SDEN RS04850
gene id: 318161:SDEN_RS04850
uniprot id: Q12QQ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Binds 1 siroheme per subunit.
messages: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.

318161:SDEN RS00005
gene id: 318161:SDEN_RS00005
uniprot id: Q12TC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

318161:SDEN RS13275
gene id: 318161:SDEN_RS13275
uniprot id: Q12L49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

318161:SDEN RS19470
gene id: 318161:SDEN_RS19470
uniprot id: Q12HR0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS00515
gene id: 318161:SDEN_RS00515
uniprot id: Q12T30
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

318161:SDEN RS11655
gene id: 318161:SDEN_RS11655
uniprot id: Q12M01
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

318161:SDEN RS07145
gene id: 318161:SDEN_RS07145
uniprot id: Q12PG6
names: Similarity
messages: Belongs to the Gfa family.

318161:SDEN RS08915
gene id: 318161:SDEN_RS08915
uniprot id: Q12NI4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

318161:SDEN RS04980
gene id: 318161:SDEN_RS04980
uniprot id: Q12QN0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

318161:SDEN RS05185
gene id: 318161:SDEN_RS05185
uniprot id: Q12QJ1
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

318161:SDEN RS17685
gene id: 318161:SDEN_RS17685
uniprot id: Q12IP6
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS02575
gene id: 318161:SDEN_RS02575
uniprot id: Q12RZ5
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

318161:SDEN RS00905
gene id: 318161:SDEN_RS00905
uniprot id: Q12SW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

318161:SDEN RS17990
gene id: 318161:SDEN_RS17990
uniprot id: Q12IJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

318161:SDEN RS01015
gene id: 318161:SDEN_RS01015
uniprot id: Q12SU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

318161:SDEN RS01710
gene id: 318161:SDEN_RS01710
uniprot id: Q12SF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoid occlusion factor SlmA family.
messages: Homodimer. Interacts with FtsZ.
messages: Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
messages: nucleoid

318161:SDEN RS05120
gene id: 318161:SDEN_RS05120
uniprot id: Q12QK4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrC family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

318161:SDEN RS00095
gene id: 318161:SDEN_RS00095
uniprot id: Q12TB0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HemG family.
messages: Binds 1 FMN non-covalently per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic conditions uses ubiquinone as an electron acceptor.
messages: Cell inner membrane

318161:SDEN RS01475
gene id: 318161:SDEN_RS01475
uniprot id: Q12SK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

318161:SDEN RS06840
gene id: 318161:SDEN_RS06840
uniprot id: Q12PM7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Secreted

318161:SDEN RS16645
gene id: 318161:SDEN_RS16645
uniprot id: Q12J97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

318161:SDEN RS13375
gene id: 318161:SDEN_RS13375
uniprot id: Q12L29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

318161:SDEN RS12705
gene id: 318161:SDEN_RS12705
uniprot id: Q12LE6
names: Cofactor
names: Similarity
messages: Belongs to the anthranilate synthase component I family.
messages: Binds 1 Mg(2+) ion per subunit.

318161:SDEN RS10840
gene id: 318161:SDEN_RS10840
uniprot id: Q12MG3
names: Similarity
messages: Belongs to the pyruvate kinase family.

318161:SDEN RS08170
gene id: 318161:SDEN_RS08170
uniprot id: Q12NX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

318161:SDEN RS12885
gene id: 318161:SDEN_RS12885
uniprot id: Q12LA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TER reductase family.
messages: Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
messages: Monomer.

318161:SDEN RS04545
gene id: 318161:SDEN_RS04545
uniprot id: Q12QW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

318161:SDEN RS14745
gene id: 318161:SDEN_RS14745
uniprot id: Q12KA9
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Belongs to the DNA photolyase family.

318161:SDEN RS09315
gene id: 318161:SDEN_RS09315
uniprot id: Q12NA3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

318161:SDEN RS08105
gene id: 318161:SDEN_RS08105
uniprot id: Q12NZ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

318161:SDEN RS03950
gene id: 318161:SDEN_RS03950
uniprot id: Q12R74
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

318161:SDEN RS09290
gene id: 318161:SDEN_RS09290
uniprot id: Q12NA8
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

318161:SDEN RS06235
gene id: 318161:SDEN_RS06235
uniprot id: Q12PZ0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

318161:SDEN RS14490
gene id: 318161:SDEN_RS14490
uniprot id: Q12KF9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS03900
gene id: 318161:SDEN_RS03900
uniprot id: Q12R84
names: Similarity
messages: Belongs to the SufE family.

318161:SDEN RS18985
gene id: 318161:SDEN_RS18985
uniprot id: Q12HZ7
names: Function
names: Similarity
messages: Belongs to the FlgN family.
messages: Required for the efficient initiation of filament assembly.

318161:SDEN RS09575
gene id: 318161:SDEN_RS09575
uniprot id: Q12N55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

318161:SDEN RS14355
gene id: 318161:SDEN_RS14355
uniprot id: Q12KI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

318161:SDEN RS18280
gene id: 318161:SDEN_RS18280
uniprot id: Q12ID4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Cell membrane
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

318161:SDEN RS10255
gene id: 318161:SDEN_RS10255
uniprot id: Q12MS7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

318161:SDEN RS08145
gene id: 318161:SDEN_RS08145
uniprot id: Q12NY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

318161:SDEN RS17695
gene id: 318161:SDEN_RS17695
uniprot id: Q12IP4
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

318161:SDEN RS19640
gene id: 318161:SDEN_RS19640
uniprot id: Q12HM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

318161:SDEN RS09055
gene id: 318161:SDEN_RS09055
uniprot id: Q12NF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamC family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

318161:SDEN RS07915
gene id: 318161:SDEN_RS07915
uniprot id: Q12P27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Syd family.
messages: Cell inner membrane
messages: Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.

318161:SDEN RS07085
gene id: 318161:SDEN_RS07085
uniprot id: Q12PH8
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS09750
gene id: 318161:SDEN_RS09750
uniprot id: Q12N26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

318161:SDEN RS02000
gene id: 318161:SDEN_RS02000
uniprot id: Q12SA4
names: Similarity
messages: Belongs to the OsmC/Ohr family.

318161:SDEN RS01745
gene id: 318161:SDEN_RS01745
uniprot id: Q12SF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

318161:SDEN RS01525
gene id: 318161:SDEN_RS01525
uniprot id: Q12SJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.
messages: Belongs to the SrkA/RdoA protein kinase family.
messages: Cytoplasm
messages: Monomer.

318161:SDEN RS15655
gene id: 318161:SDEN_RS15655
uniprot id: Q12JT7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.

318161:SDEN RS18950
gene id: 318161:SDEN_RS18950
uniprot id: Q12I04
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

318161:SDEN RS13970
gene id: 318161:SDEN_RS13970
uniprot id: Q12KR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

318161:SDEN RS05350
gene id: 318161:SDEN_RS05350
uniprot id: Q12QG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.

318161:SDEN RS00315
gene id: 318161:SDEN_RS00315
uniprot id: Q12T69
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

318161:SDEN RS02060
gene id: 318161:SDEN_RS02060
uniprot id: Q12S92
names: Function
names: Similarity
messages: Belongs to the frataxin family.
messages: Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.

318161:SDEN RS07485
gene id: 318161:SDEN_RS07485
uniprot id: Q12PA9
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the phosphorylation of guanosine and inosine to GMP and IMP, respectively.

318161:SDEN RS05365
gene id: 318161:SDEN_RS05365
uniprot id: Q12QF7
names: Similarity
messages: Belongs to the Smp family.

318161:SDEN RS16585
gene id: 318161:SDEN_RS16585
uniprot id: Q12JA9
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family. AstD subfamily.
messages: Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.

318161:SDEN RS00625
gene id: 318161:SDEN_RS00625
uniprot id: Q12T08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family. GSP D subfamily.
messages: Cell outer membrane
messages: Membrane

318161:SDEN RS16090
gene id: 318161:SDEN_RS16090
uniprot id: Q12JK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CsgA/CsgB family.
messages: Fimbrium

318161:SDEN RS06555
gene id: 318161:SDEN_RS06555
uniprot id: Q12PT3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS11400
gene id: 318161:SDEN_RS11400
uniprot id: Q12M53
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

318161:SDEN RS11530
gene id: 318161:SDEN_RS11530
uniprot id: Q12M27
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NosZ family.
messages: Binds 2 calcium ions per subunit.
messages: Binds 6 Cu cations per subunit. Each subunit contains 2 copper centers; Cu(A) (binuclear) and Cu(Z) (tetranuclear). Cu(Z) is thought to be the site of nitrous oxide reduction.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.
messages: Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

318161:SDEN RS01415
gene id: 318161:SDEN_RS01415
uniprot id: Q12SL8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

318161:SDEN RS07395
gene id: 318161:SDEN_RS07395
uniprot id: Q12PC7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

318161:SDEN RS02635
gene id: 318161:SDEN_RS02635
uniprot id: Q12RY3
names: Similarity
messages: Belongs to the BolA/IbaG family.

318161:SDEN RS09540
gene id: 318161:SDEN_RS09540
uniprot id: Q12N62
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

318161:SDEN RS18925
gene id: 318161:SDEN_RS18925
uniprot id: Q12I09
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

318161:SDEN RS15765
gene id: 318161:SDEN_RS15765
uniprot id: Q12JR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

318161:SDEN RS01120
gene id: 318161:SDEN_RS01120
uniprot id: Q12SR9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

318161:SDEN RS05940
gene id: 318161:SDEN_RS05940
uniprot id: Q12Q47
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

318161:SDEN RS19545
gene id: 318161:SDEN_RS19545
uniprot id: Q12HP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.

318161:SDEN RS11885
gene id: 318161:SDEN_RS11885
uniprot id: Q12LV5
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

318161:SDEN RS04695
gene id: 318161:SDEN_RS04695
uniprot id: Q12QT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm

318161:SDEN RS12245
gene id: 318161:SDEN_RS12245
uniprot id: Q12LN4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

318161:SDEN RS03300
gene id: 318161:SDEN_RS03300
uniprot id: Q12RK5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS07900
gene id: 318161:SDEN_RS07900
uniprot id: Q12P30
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

318161:SDEN RS13040
gene id: 318161:SDEN_RS13040
uniprot id: Q12L81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZipA family.
messages: Cell inner membrane
messages: Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.
messages: Interacts with FtsZ via their C-terminal domains.

318161:SDEN RS02740
gene id: 318161:SDEN_RS02740
uniprot id: Q12RW2
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

318161:SDEN RS11070
gene id: 318161:SDEN_RS11070
uniprot id: Q12MB8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

318161:SDEN RS06850
gene id: 318161:SDEN_RS06850
uniprot id: Q12PM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

318161:SDEN RS15110
gene id: 318161:SDEN_RS15110
uniprot id: Q12K40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

318161:SDEN RS12995
gene id: 318161:SDEN_RS12995
uniprot id: Q12L90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

318161:SDEN RS06910
gene id: 318161:SDEN_RS06910
uniprot id: Q12PL3
names: Subcellular Location Annotation
messages: Cytoplasm

318161:SDEN RS03625
gene id: 318161:SDEN_RS03625
uniprot id: Q12RD9
names: Similarity
messages: Belongs to the PspA/IM30 family.

318161:SDEN RS07840
gene id: 318161:SDEN_RS07840
uniprot id: Q12P43
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapB family.
messages: Binds 2 heme C groups per subunit.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Electron transfer subunit of the periplasmic nitrate reductase complex NapAB.
messages: Periplasm

318161:SDEN RS10100
gene id: 318161:SDEN_RS10100
uniprot id: Q12MV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

318161:SDEN RS01370
gene id: 318161:SDEN_RS01370
uniprot id: Q12SM7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

318161:SDEN RS17165
gene id: 318161:SDEN_RS17165
uniprot id: Q12IZ7
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS11095
gene id: 318161:SDEN_RS11095
uniprot id: Q12MB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S51 family.
messages: Cytoplasm
messages: Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.

318161:SDEN RS00820
gene id: 318161:SDEN_RS00820
uniprot id: Q12SX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

318161:SDEN RS13585
gene id: 318161:SDEN_RS13585
uniprot id: Q12KY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS07990
gene id: 318161:SDEN_RS07990
uniprot id: Q12P12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
messages: Cytoplasm
messages: Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).

318161:SDEN RS09180
gene id: 318161:SDEN_RS09180
uniprot id: Q12ND1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

318161:SDEN RS06905
gene id: 318161:SDEN_RS06905
uniprot id: Q12PL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliH family.
messages: Cytoplasm
messages: Needed for flagellar regrowth and assembly.

318161:SDEN RS16255
gene id: 318161:SDEN_RS16255
uniprot id: Q12JH2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS05270
gene id: 318161:SDEN_RS05270
uniprot id: Q12QH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

318161:SDEN RS13680
gene id: 318161:SDEN_RS13680
uniprot id: Q12KW8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS03555
gene id: 318161:SDEN_RS03555
uniprot id: Q12RF3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS10530
gene id: 318161:SDEN_RS10530
uniprot id: Q12MM5
names: Function
names: Subunit
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

318161:SDEN RS16620
gene id: 318161:SDEN_RS16620
uniprot id: Q12JA2
names: Similarity
messages: Belongs to the GST superfamily. HSP26 family.

318161:SDEN RS04820
gene id: 318161:SDEN_RS04820
uniprot id: Q12QR1
names: Subcellular Location Annotation
messages: Cytoplasm

318161:SDEN RS15415
gene id: 318161:SDEN_RS15415
uniprot id: Q12JY5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS13765
gene id: 318161:SDEN_RS13765
uniprot id: Q12KV1
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

318161:SDEN RS17210
gene id: 318161:SDEN_RS17210
uniprot id: Q12IY7
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

318161:SDEN RS09850
gene id: 318161:SDEN_RS09850
uniprot id: Q12N06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS16795
gene id: 318161:SDEN_RS16795
uniprot id: Q12J70
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS15130
gene id: 318161:SDEN_RS15130
uniprot id: Q12K36
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

318161:SDEN RS15340
gene id: 318161:SDEN_RS15340
uniprot id: Q12JZ9
names: Similarity
messages: Belongs to the DEAD box helicase family.

318161:SDEN RS05310
gene id: 318161:SDEN_RS05310
uniprot id: Q12QG8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer.
messages: May be involved in cell division.

318161:SDEN RS11995
gene id: 318161:SDEN_RS11995
uniprot id: Q12LT3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

318161:SDEN RS11690
gene id: 318161:SDEN_RS11690
uniprot id: Q12LZ4
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

318161:SDEN RS13805
gene id: 318161:SDEN_RS13805
uniprot id: Q12KU3
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

318161:SDEN RS15250
gene id: 318161:SDEN_RS15250
uniprot id: Q12K13
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS11895
gene id: 318161:SDEN_RS11895
uniprot id: Q12LV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

318161:SDEN RS17005
gene id: 318161:SDEN_RS17005
uniprot id: Q12J30
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

318161:SDEN RS08095
gene id: 318161:SDEN_RS08095
uniprot id: Q12NZ2
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

318161:SDEN RS07565
gene id: 318161:SDEN_RS07565
uniprot id: Q12P97
names: Similarity
messages: Belongs to the extradiol ring-cleavage dioxygenase family.

318161:SDEN RS05205
gene id: 318161:SDEN_RS05205
uniprot id: Q12QI7
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

318161:SDEN RS03410
gene id: 318161:SDEN_RS03410
uniprot id: Q12RI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm
messages: Purine salvage pathway enzyme which catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of hypoxanthine to yield IMP (inosine 5'-monophosphate). To a lesser extent, can also act on guanine leading to GMP, but shows a highly less efficient activity with xanthine.

318161:SDEN RS13415
gene id: 318161:SDEN_RS13415
uniprot id: Q12L21
names: Similarity
messages: Belongs to the DEAD box helicase family.

318161:SDEN RS07060
gene id: 318161:SDEN_RS07060
uniprot id: Q12PI3
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS16770
gene id: 318161:SDEN_RS16770
uniprot id: Q12J75
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

318161:SDEN RS07570
gene id: 318161:SDEN_RS07570
uniprot id: Q12P96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS00355
gene id: 318161:SDEN_RS00355
uniprot id: Q12T61
names: Similarity
messages: Belongs to the peptidase S33 family.

318161:SDEN RS00500
gene id: 318161:SDEN_RS00500
uniprot id: Q12T33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

318161:SDEN RS13845
gene id: 318161:SDEN_RS13845
uniprot id: Q12KT5
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

318161:SDEN RS19210
gene id: 318161:SDEN_RS19210
uniprot id: Q12HV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

318161:SDEN RS00400
gene id: 318161:SDEN_RS00400
uniprot id: Q12T52
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Monomer.

318161:SDEN RS13225
gene id: 318161:SDEN_RS13225
uniprot id: Q12L59
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

318161:SDEN RS09570
gene id: 318161:SDEN_RS09570
uniprot id: Q12N56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-transferase family. Bpt subfamily.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.

318161:SDEN RS00670
gene id: 318161:SDEN_RS00670
uniprot id: Q12SZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP M family.
messages: Cell inner membrane
messages: Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

318161:SDEN RS10720
gene id: 318161:SDEN_RS10720
uniprot id: Q12MI8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

318161:SDEN RS17590
gene id: 318161:SDEN_RS17590
uniprot id: Q12IR3
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

318161:SDEN RS08035
gene id: 318161:SDEN_RS08035
uniprot id: Q12P03
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS01345
gene id: 318161:SDEN_RS01345
uniprot id: Q12SN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

318161:SDEN RS10380
gene id: 318161:SDEN_RS10380
uniprot id: Q12MQ2
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 104 family.
messages: Protein-arginine rhamnosyltransferase that catalyzes the transfer of a single rhamnose to elongation factor P (EF-P) on 'Lys-32', a modification required for EF-P-dependent rescue of polyproline stalled ribosomes.

318161:SDEN RS18285
gene id: 318161:SDEN_RS18285
uniprot id: Q12ID3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

318161:SDEN RS08360
gene id: 318161:SDEN_RS08360
uniprot id: Q12NU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

318161:SDEN RS17765
gene id: 318161:SDEN_RS17765
uniprot id: Q12IN0
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

318161:SDEN RS09675
gene id: 318161:SDEN_RS09675
uniprot id: Q12N35
names: Similarity
messages: Belongs to the transglycosylase Slt family.

318161:SDEN RS07190
gene id: 318161:SDEN_RS07190
uniprot id: Q12PF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

318161:SDEN RS18220
gene id: 318161:SDEN_RS18220
uniprot id: Q12IE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

318161:SDEN RS17830
gene id: 318161:SDEN_RS17830
uniprot id: Q12IL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

318161:SDEN RS13390
gene id: 318161:SDEN_RS13390
uniprot id: Q12L26
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

318161:SDEN RS08185
gene id: 318161:SDEN_RS08185
uniprot id: Q12NX4
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

318161:SDEN RS02195
gene id: 318161:SDEN_RS02195
uniprot id: Q12S70
names: Similarity
messages: Belongs to the aldose epimerase family.

318161:SDEN RS14315
gene id: 318161:SDEN_RS14315
uniprot id: Q12KJ3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

318161:SDEN RS09980
gene id: 318161:SDEN_RS09980
uniprot id: Q12MY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

318161:SDEN RS14245
gene id: 318161:SDEN_RS14245
uniprot id: Q12KK7
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

318161:SDEN RS10905
gene id: 318161:SDEN_RS10905
uniprot id: Q12MF1
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

318161:SDEN RS01805
gene id: 318161:SDEN_RS01805
uniprot id: Q12SD9
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

318161:SDEN RS03920
gene id: 318161:SDEN_RS03920
uniprot id: Q12R80
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

318161:SDEN RS17605
gene id: 318161:SDEN_RS17605
uniprot id: Q12IR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS13125
gene id: 318161:SDEN_RS13125
uniprot id: Q12L64
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS04565
gene id: 318161:SDEN_RS04565
uniprot id: Q12QW2
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS08370
gene id: 318161:SDEN_RS08370
uniprot id: Q12NT9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

318161:SDEN RS05960
gene id: 318161:SDEN_RS05960
uniprot id: Q12Q43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

318161:SDEN RS04145
gene id: 318161:SDEN_RS04145
uniprot id: Q12R35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS13365
gene id: 318161:SDEN_RS13365
uniprot id: Q12L31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

318161:SDEN RS05825
gene id: 318161:SDEN_RS05825
uniprot id: Q12Q70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell inner membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

318161:SDEN RS16745
gene id: 318161:SDEN_RS16745
uniprot id: Q12J80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

318161:SDEN RS14395
gene id: 318161:SDEN_RS14395
uniprot id: Q12KH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RseB family.
messages: Periplasm

318161:SDEN RS17310
gene id: 318161:SDEN_RS17310
uniprot id: Q12IW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Cell inner membrane
messages: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.
messages: Membrane

318161:SDEN RS07470
gene id: 318161:SDEN_RS07470
uniprot id: Q12PB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Molecular chaperone. Has ATPase activity.

318161:SDEN RS07220
gene id: 318161:SDEN_RS07220
uniprot id: Q12PF6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.

318161:SDEN RS16015
gene id: 318161:SDEN_RS16015
uniprot id: Q12JL9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

318161:SDEN RS15205
gene id: 318161:SDEN_RS15205
uniprot id: Q12K22
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

318161:SDEN RS06355
gene id: 318161:SDEN_RS06355
uniprot id: Q12PX2
names: Similarity
messages: Belongs to the peptidase M16 family.

318161:SDEN RS10350
gene id: 318161:SDEN_RS10350
uniprot id: Q12MQ8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

318161:SDEN RS06945
gene id: 318161:SDEN_RS06945
uniprot id: Q12PK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell membrane
messages: FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

318161:SDEN RS18400
gene id: 318161:SDEN_RS18400
uniprot id: Q12IB1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

318161:SDEN RS02130
gene id: 318161:SDEN_RS02130
uniprot id: Q12S79
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

318161:SDEN RS05635
gene id: 318161:SDEN_RS05635
uniprot id: Q12QA7
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

318161:SDEN RS08120
gene id: 318161:SDEN_RS08120
uniprot id: Q12NY7
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

318161:SDEN RS17965
gene id: 318161:SDEN_RS17965
uniprot id: Q12IJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

318161:SDEN RS13670
gene id: 318161:SDEN_RS13670
uniprot id: Q12KX0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

318161:SDEN RS13045
gene id: 318161:SDEN_RS13045
uniprot id: Q12L80
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

318161:SDEN RS05235
gene id: 318161:SDEN_RS05235
uniprot id: Q12QI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

318161:SDEN RS08180
gene id: 318161:SDEN_RS08180
uniprot id: Q12NX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

318161:SDEN RS17955
gene id: 318161:SDEN_RS17955
uniprot id: Q12IJ8
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS00535
gene id: 318161:SDEN_RS00535
uniprot id: Q12T26
names: Similarity
messages: Belongs to the MoaD family.

318161:SDEN RS01440
gene id: 318161:SDEN_RS01440
uniprot id: Q12SL3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

318161:SDEN RS12965
gene id: 318161:SDEN_RS12965
uniprot id: Q12L96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxH family.
messages: Binds 2 Mn(2+) ions per subunit in a binuclear metal center.
messages: Cell inner membrane
messages: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

318161:SDEN RS15475
gene id: 318161:SDEN_RS15475
uniprot id: Q12JX3
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

318161:SDEN RS14800
gene id: 318161:SDEN_RS14800
uniprot id: Q12K98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

318161:SDEN RS18100
gene id: 318161:SDEN_RS18100
uniprot id: Q12IG9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Binds 1 Cu(+) ion.
messages: Homotrimer.
messages: Periplasm

318161:SDEN RS15775
gene id: 318161:SDEN_RS15775
uniprot id: Q12JR6
names: Similarity
messages: Belongs to the glutamine synthetase family.

318161:SDEN RS10395
gene id: 318161:SDEN_RS10395
uniprot id: Q12MP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 5DNU family.
messages: Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS18290
gene id: 318161:SDEN_RS18290
uniprot id: Q12ID2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX11/CtaG family.
messages: Cell inner membrane
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.

318161:SDEN RS16635
gene id: 318161:SDEN_RS16635
uniprot id: Q12J99
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

318161:SDEN RS14885
gene id: 318161:SDEN_RS14885
uniprot id: Q12K84
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

318161:SDEN RS04675
gene id: 318161:SDEN_RS04675
uniprot id: Q12QU0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

318161:SDEN RS12810
gene id: 318161:SDEN_RS12810
uniprot id: Q12LC5
names: Similarity
messages: Belongs to the peptidase S49 family.

318161:SDEN RS15030
gene id: 318161:SDEN_RS15030
uniprot id: Q12K57
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

318161:SDEN RS00070
gene id: 318161:SDEN_RS00070
uniprot id: Q12TB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
messages: Cytoplasm
messages: Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).

318161:SDEN RS00825
gene id: 318161:SDEN_RS00825
uniprot id: Q12SX5
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
messages: Belongs to the biotin--protein ligase family.

318161:SDEN RS12110
gene id: 318161:SDEN_RS12110
uniprot id: Q12LR0
names: Similarity
messages: Belongs to the UPF0352 family.

318161:SDEN RS01895
gene id: 318161:SDEN_RS01895
uniprot id: Q12SC1
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

318161:SDEN RS14650
gene id: 318161:SDEN_RS14650
uniprot id: Q12KC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
messages: Membrane

318161:SDEN RS12165
gene id: 318161:SDEN_RS12165
uniprot id: Q12LQ0
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

318161:SDEN RS18350
gene id: 318161:SDEN_RS18350
uniprot id: Q12IC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
messages: Cytoplasm
messages: Monomer.
messages: The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.

318161:SDEN RS15740
gene id: 318161:SDEN_RS15740
uniprot id: Q12JS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. RhlE subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

318161:SDEN RS18885
gene id: 318161:SDEN_RS18885
uniprot id: Q12I17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

318161:SDEN RS09520
gene id: 318161:SDEN_RS09520
uniprot id: Q12N66
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

318161:SDEN RS07855
gene id: 318161:SDEN_RS07855
uniprot id: Q12P40
names: Similarity
messages: Belongs to the YkuD family.

318161:SDEN RS11365
gene id: 318161:SDEN_RS11365
uniprot id: Q12M60
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

318161:SDEN RS02970
gene id: 318161:SDEN_RS02970
uniprot id: Q12RS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Slam family.
messages: Cell outer membrane
messages: Membrane

318161:SDEN RS00885
gene id: 318161:SDEN_RS00885
uniprot id: Q12SW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

318161:SDEN RS17560
gene id: 318161:SDEN_RS17560
uniprot id: Q12IR9
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

318161:SDEN RS11585
gene id: 318161:SDEN_RS11585
uniprot id: Q12M15
names: Similarity
messages: Belongs to the FrmR/RcnR family.

318161:SDEN RS11255
gene id: 318161:SDEN_RS11255
uniprot id: Q12M82
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

318161:SDEN RS11960
gene id: 318161:SDEN_RS11960
uniprot id: Q12LU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

318161:SDEN RS12105
gene id: 318161:SDEN_RS12105
uniprot id: Q12LR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

318161:SDEN RS06615
gene id: 318161:SDEN_RS06615
uniprot id: Q12PS1
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

318161:SDEN RS09645
gene id: 318161:SDEN_RS09645
uniprot id: Q12N41
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

318161:SDEN RS00665
gene id: 318161:SDEN_RS00665
uniprot id: Q12T00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP L family.
messages: Cell inner membrane
messages: Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

318161:SDEN RS03795
gene id: 318161:SDEN_RS03795
uniprot id: Q12RA5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS05540
gene id: 318161:SDEN_RS05540
uniprot id: Q12QC6
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.

318161:SDEN RS08740
gene id: 318161:SDEN_RS08740
uniprot id: Q12NL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
messages: The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).

318161:SDEN RS14220
gene id: 318161:SDEN_RS14220
uniprot id: Q12KL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

318161:SDEN RS15230
gene id: 318161:SDEN_RS15230
uniprot id: Q12K17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS12750
gene id: 318161:SDEN_RS12750
uniprot id: Q12LD7
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS15260
gene id: 318161:SDEN_RS15260
uniprot id: Q12K11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmG family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.

318161:SDEN RS10920
gene id: 318161:SDEN_RS10920
uniprot id: Q12ME8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS02730
gene id: 318161:SDEN_RS02730
uniprot id: Q12RW4
names: Similarity
messages: Belongs to the peptidase S46 family.

318161:SDEN RS12435
gene id: 318161:SDEN_RS12435
uniprot id: Q12LK1
names: Similarity
messages: Belongs to the Gfa family.

318161:SDEN RS13515
gene id: 318161:SDEN_RS13515
uniprot id: Q12L01
names: Similarity
messages: Belongs to the UDPGP type 2 family.

318161:SDEN RS05345
gene id: 318161:SDEN_RS05345
uniprot id: Q12QG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

318161:SDEN RS08410
gene id: 318161:SDEN_RS08410
uniprot id: Q12NT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

318161:SDEN RS05640
gene id: 318161:SDEN_RS05640
uniprot id: Q12QA6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

318161:SDEN RS06975
gene id: 318161:SDEN_RS06975
uniprot id: Q12PK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

318161:SDEN RS04740
gene id: 318161:SDEN_RS04740
uniprot id: Q12QS7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

318161:SDEN RS20015
gene id: 318161:SDEN_RS20015
uniprot id: Q12ST8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

318161:SDEN RS06530
gene id: 318161:SDEN_RS06530
uniprot id: Q12PT8
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

318161:SDEN RS09860
gene id: 318161:SDEN_RS09860
uniprot id: Q12N04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
messages: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
messages: Homodimer.

318161:SDEN RS12350
gene id: 318161:SDEN_RS12350
uniprot id: Q12LL7
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

318161:SDEN RS02560
gene id: 318161:SDEN_RS02560
uniprot id: Q12RZ8
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

318161:SDEN RS17495
gene id: 318161:SDEN_RS17495
uniprot id: Q12IT2
names: Similarity
messages: Belongs to the CFA/CMAS family.

318161:SDEN RS03820
gene id: 318161:SDEN_RS03820
uniprot id: Q12RA0
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.
messages: Homotetramer.

318161:SDEN RS11855
gene id: 318161:SDEN_RS11855
uniprot id: Q12LW1
names: Subcellular Location Annotation
messages: Cytoplasm

318161:SDEN RS00930
gene id: 318161:SDEN_RS00930
uniprot id: Q12SV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

318161:SDEN RS08735
gene id: 318161:SDEN_RS08735
uniprot id: Q12NL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

318161:SDEN RS02705
gene id: 318161:SDEN_RS02705
uniprot id: Q12RW9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

318161:SDEN RS04080
gene id: 318161:SDEN_RS04080
uniprot id: Q12R48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

318161:SDEN RS02040
gene id: 318161:SDEN_RS02040
uniprot id: Q12S96
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS00805
gene id: 318161:SDEN_RS00805
uniprot id: Q12SX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

318161:SDEN RS11925
gene id: 318161:SDEN_RS11925
uniprot id: Q12LU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YceF subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

318161:SDEN RS08050
gene id: 318161:SDEN_RS08050
uniprot id: Q12P00
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

318161:SDEN RS12205
gene id: 318161:SDEN_RS12205
uniprot id: Q12LP2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

318161:SDEN RS01195
gene id: 318161:SDEN_RS01195
uniprot id: Q12SQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

318161:SDEN RS15470
gene id: 318161:SDEN_RS15470
uniprot id: Q12JX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

318161:SDEN RS01425
gene id: 318161:SDEN_RS01425
uniprot id: Q12SL6
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

318161:SDEN RS01410
gene id: 318161:SDEN_RS01410
uniprot id: Q12SL9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

318161:SDEN RS02585
gene id: 318161:SDEN_RS02585
uniprot id: Q12RZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptA family.
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
messages: Periplasm

318161:SDEN RS12580
gene id: 318161:SDEN_RS12580
uniprot id: Q12LH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

318161:SDEN RS13115
gene id: 318161:SDEN_RS13115
uniprot id: Q12L66
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

318161:SDEN RS01020
gene id: 318161:SDEN_RS01020
uniprot id: Q12ST9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

318161:SDEN RS06560
gene id: 318161:SDEN_RS06560
uniprot id: Q12PT2
names: Similarity
messages: Belongs to the YfgM family.

318161:SDEN RS17625
gene id: 318161:SDEN_RS17625
uniprot id: Q12IQ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA gyrase inhibitor YacG family.
messages: Binds 1 zinc ion.
messages: Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
messages: Interacts with GyrB.

318161:SDEN RS03230
gene id: 318161:SDEN_RS03230
uniprot id: Q12RL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS06965
gene id: 318161:SDEN_RS06965
uniprot id: Q12PK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

318161:SDEN RS03415
gene id: 318161:SDEN_RS03415
uniprot id: Q12RI1
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS16485
gene id: 318161:SDEN_RS16485
uniprot id: Q12JC9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

318161:SDEN RS07255
gene id: 318161:SDEN_RS07255
uniprot id: Q12PE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

318161:SDEN RS14550
gene id: 318161:SDEN_RS14550
uniprot id: Q12KE7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS00675
gene id: 318161:SDEN_RS00675
uniprot id: Q12SZ8
names: Similarity
messages: Belongs to the GSP N family.

318161:SDEN RS02425
gene id: 318161:SDEN_RS02425
uniprot id: Q12S24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiJ family.
messages: Cytoplasm
messages: Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.

318161:SDEN RS02020
gene id: 318161:SDEN_RS02020
uniprot id: Q12SA0
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

318161:SDEN RS19635
gene id: 318161:SDEN_RS19635
uniprot id: Q12HM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

318161:SDEN RS06305
gene id: 318161:SDEN_RS06305
uniprot id: Q12PX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

318161:SDEN RS07490
gene id: 318161:SDEN_RS07490
uniprot id: Q12PA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

318161:SDEN RS19220
gene id: 318161:SDEN_RS19220
uniprot id: Q12HV5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

318161:SDEN RS09015
gene id: 318161:SDEN_RS09015
uniprot id: Q12NG4
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS09070
gene id: 318161:SDEN_RS09070
uniprot id: Q12NF3
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS06090
gene id: 318161:SDEN_RS06090
uniprot id: Q12Q20
names: Cofactor
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.

318161:SDEN RS16765
gene id: 318161:SDEN_RS16765
uniprot id: Q12J76
names: Function
names: Similarity
messages: Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process.
messages: Belongs to the Nudix hydrolase family. NudF subfamily.

318161:SDEN RS16085
gene id: 318161:SDEN_RS16085
uniprot id: Q12JK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CsgA/CsgB family.
messages: Fimbrium

318161:SDEN RS14330
gene id: 318161:SDEN_RS14330
uniprot id: Q12KJ0
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS14105
gene id: 318161:SDEN_RS14105
uniprot id: Q12KN5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS16595
gene id: 318161:SDEN_RS16595
uniprot id: Q12JA7
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

318161:SDEN RS11830
gene id: 318161:SDEN_RS11830
uniprot id: Q12LW6
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

318161:SDEN RS08580
gene id: 318161:SDEN_RS08580
uniprot id: Q12NP6
names: Similarity
messages: Belongs to the ArsC family.

318161:SDEN RS12605
gene id: 318161:SDEN_RS12605
uniprot id: Q12LG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

318161:SDEN RS00480
gene id: 318161:SDEN_RS00480
uniprot id: Q12T37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS00990
gene id: 318161:SDEN_RS00990
uniprot id: Q12SU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

318161:SDEN RS02305
gene id: 318161:SDEN_RS02305
uniprot id: Q12S48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0114 family.
messages: Cell membrane

318161:SDEN RS06385
gene id: 318161:SDEN_RS06385
uniprot id: Q12PW6
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

318161:SDEN RS05475
gene id: 318161:SDEN_RS05475
uniprot id: Q12QD7
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

318161:SDEN RS04985
gene id: 318161:SDEN_RS04985
uniprot id: Q12QM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PAPS reductase family. CysD subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

318161:SDEN RS03700
gene id: 318161:SDEN_RS03700
uniprot id: Q12RC4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

318161:SDEN RS12865
gene id: 318161:SDEN_RS12865
uniprot id: Q12LB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

318161:SDEN RS02240
gene id: 318161:SDEN_RS02240
uniprot id: Q12S61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

318161:SDEN RS16820
gene id: 318161:SDEN_RS16820
uniprot id: Q12J66
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

318161:SDEN RS03330
gene id: 318161:SDEN_RS03330
uniprot id: Q12RJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS01505
gene id: 318161:SDEN_RS01505
uniprot id: Q12SK0
names: Similarity
messages: Belongs to the peptidase S9C family.

318161:SDEN RS11880
gene id: 318161:SDEN_RS11880
uniprot id: Q12LV6
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

318161:SDEN RS15720
gene id: 318161:SDEN_RS15720
uniprot id: Q12JS6
names: Similarity
messages: Belongs to the Gfa family.

318161:SDEN RS11905
gene id: 318161:SDEN_RS11905
uniprot id: Q12LV1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

318161:SDEN RS08770
gene id: 318161:SDEN_RS08770
uniprot id: Q12NK9
names: Subcellular Location Annotation
messages: Cell inner membrane

318161:SDEN RS14955
gene id: 318161:SDEN_RS14955
uniprot id: Q12K72
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS14095
gene id: 318161:SDEN_RS14095
uniprot id: Q12KN7
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

318161:SDEN RS04055
gene id: 318161:SDEN_RS04055
uniprot id: Q12R53
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS14460
gene id: 318161:SDEN_RS14460
uniprot id: Q12KG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MutH family.
messages: Cytoplasm
messages: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.

318161:SDEN RS13850
gene id: 318161:SDEN_RS13850
uniprot id: Q12KT4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

318161:SDEN RS11950
gene id: 318161:SDEN_RS11950
uniprot id: Q12LU2
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

318161:SDEN RS16500
gene id: 318161:SDEN_RS16500
uniprot id: Q12JC6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

318161:SDEN RS13110
gene id: 318161:SDEN_RS13110
uniprot id: Q12L67
names: Similarity
messages: Belongs to the DEAD box helicase family.

318161:SDEN RS14560
gene id: 318161:SDEN_RS14560
uniprot id: Q12KE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Membrane

318161:SDEN RS14830
gene id: 318161:SDEN_RS14830
uniprot id: Q12K92
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein S18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS03265
gene id: 318161:SDEN_RS03265
uniprot id: Q12RL2
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS01010
gene id: 318161:SDEN_RS01010
uniprot id: Q12SU1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

318161:SDEN RS01880
gene id: 318161:SDEN_RS01880
uniprot id: Q12SC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsQ/DivIB family. FtsQ subfamily.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

318161:SDEN RS12525
gene id: 318161:SDEN_RS12525
uniprot id: Q12LI3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

318161:SDEN RS02735
gene id: 318161:SDEN_RS02735
uniprot id: Q12RW3
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

318161:SDEN RS11810
gene id: 318161:SDEN_RS11810
uniprot id: Q12LX0
names: Similarity
messages: Belongs to the UPF0178 family.

318161:SDEN RS13985
gene id: 318161:SDEN_RS13985
uniprot id: Q12KQ7
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

318161:SDEN RS18560
gene id: 318161:SDEN_RS18560
uniprot id: Q12I81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

318161:SDEN RS02410
gene id: 318161:SDEN_RS02410
uniprot id: Q12S27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

318161:SDEN RS14000
gene id: 318161:SDEN_RS14000
uniprot id: Q12KQ4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS03685
gene id: 318161:SDEN_RS03685
uniprot id: Q12RC7
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytidylyltransferase family.
messages: In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

318161:SDEN RS06860
gene id: 318161:SDEN_RS06860
uniprot id: Q12PM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

318161:SDEN RS08320
gene id: 318161:SDEN_RS08320
uniprot id: Q12NU9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

318161:SDEN RS03420
gene id: 318161:SDEN_RS03420
uniprot id: Q12RI0
names: Function
names: Similarity
messages: Belongs to the MurCDEF family. Mpl subfamily.
messages: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.

318161:SDEN RS05625
gene id: 318161:SDEN_RS05625
uniprot id: Q12QA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

318161:SDEN RS15700
gene id: 318161:SDEN_RS15700
uniprot id: Q12JS9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS13825
gene id: 318161:SDEN_RS13825
uniprot id: Q12KT9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

318161:SDEN RS15935
gene id: 318161:SDEN_RS15935
uniprot id: Q12JN5
names: Similarity
messages: Belongs to the SAICAR synthetase family.

318161:SDEN RS10170
gene id: 318161:SDEN_RS10170
uniprot id: Q12MU4
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

318161:SDEN RS12160
gene id: 318161:SDEN_RS12160
uniprot id: Q12LQ1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrP family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

318161:SDEN RS09185
gene id: 318161:SDEN_RS09185
uniprot id: Q12ND0
names: Similarity
messages: Belongs to the YciI family.

318161:SDEN RS15090
gene id: 318161:SDEN_RS15090
uniprot id: Q12K44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

318161:SDEN RS12370
gene id: 318161:SDEN_RS12370
uniprot id: Q12LL3
names: Subcellular Location Annotation
messages: Cell inner membrane

318161:SDEN RS00875
gene id: 318161:SDEN_RS00875
uniprot id: Q12SW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

318161:SDEN RS02775
gene id: 318161:SDEN_RS02775
uniprot id: Q12RV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

318161:SDEN RS18725
gene id: 318161:SDEN_RS18725
uniprot id: Q12I49
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

318161:SDEN RS17415
gene id: 318161:SDEN_RS17415
uniprot id: Q12IU7
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

318161:SDEN RS14320
gene id: 318161:SDEN_RS14320
uniprot id: Q12KJ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

318161:SDEN RS08375
gene id: 318161:SDEN_RS08375
uniprot id: Q12NT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

318161:SDEN RS03860
gene id: 318161:SDEN_RS03860
uniprot id: Q12R92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. SrmB subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity.
messages: Interacts with the 50S ribosomal subunit.

318161:SDEN RS13215
gene id: 318161:SDEN_RS13215
uniprot id: Q12L61
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

318161:SDEN RS04200
gene id: 318161:SDEN_RS04200
uniprot id: Q12R26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS05170
gene id: 318161:SDEN_RS05170
uniprot id: Q12QJ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

318161:SDEN RS00045
gene id: 318161:SDEN_RS00045
uniprot id: Q12TC0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

318161:SDEN RS19645
gene id: 318161:SDEN_RS19645
uniprot id: Q12HM5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

318161:SDEN RS09025
gene id: 318161:SDEN_RS09025
uniprot id: Q12NG2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

318161:SDEN RS12985
gene id: 318161:SDEN_RS12985
uniprot id: Q12L92
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS04720
gene id: 318161:SDEN_RS04720
uniprot id: Q12QT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

318161:SDEN RS00590
gene id: 318161:SDEN_RS00590
uniprot id: Q12T15
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

318161:SDEN RS06465
gene id: 318161:SDEN_RS06465
uniprot id: Q12PV0
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

318161:SDEN RS03710
gene id: 318161:SDEN_RS03710
uniprot id: Q12RC2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

318161:SDEN RS00015
gene id: 318161:SDEN_RS00015
uniprot id: Q12TC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

318161:SDEN RS09460
gene id: 318161:SDEN_RS09460
uniprot id: Q12N78
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

318161:SDEN RS19325
gene id: 318161:SDEN_RS19325
uniprot id: Q12HT9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

318161:SDEN RS08545
gene id: 318161:SDEN_RS08545
uniprot id: Q12NQ3
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

318161:SDEN RS16655
gene id: 318161:SDEN_RS16655
uniprot id: Q12J95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

318161:SDEN RS15345
gene id: 318161:SDEN_RS15345
uniprot id: Q12JZ8
names: Similarity
messages: Belongs to the pirin family.

318161:SDEN RS05110
gene id: 318161:SDEN_RS05110
uniprot id: Q12QK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

318161:SDEN RS17230
gene id: 318161:SDEN_RS17230
uniprot id: Q12IY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

318161:SDEN RS11835
gene id: 318161:SDEN_RS11835
uniprot id: Q12LW5
names: Similarity
messages: Belongs to the CvfB family.

318161:SDEN RS15980
gene id: 318161:SDEN_RS15980
uniprot id: Q12JM6
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS19010
gene id: 318161:SDEN_RS19010
uniprot id: Q12HZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively.

318161:SDEN RS06550
gene id: 318161:SDEN_RS06550
uniprot id: Q12PT4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

318161:SDEN RS04690
gene id: 318161:SDEN_RS04690
uniprot id: Q12QT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS01695
gene id: 318161:SDEN_RS01695
uniprot id: Q12SG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

318161:SDEN RS18775
gene id: 318161:SDEN_RS18775
uniprot id: Q12I39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. KdkA/RfaP family.
messages: Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS02065
gene id: 318161:SDEN_RS02065
uniprot id: Q12S91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

318161:SDEN RS00115
gene id: 318161:SDEN_RS00115
uniprot id: Q12TA6
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

318161:SDEN RS09030
gene id: 318161:SDEN_RS09030
uniprot id: Q12NG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapC family.
messages: Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.
messages: Cytoplasm
messages: Interacts directly with FtsZ.

318161:SDEN RS19630
gene id: 318161:SDEN_RS19630
uniprot id: Q12HM9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

318161:SDEN RS13300
gene id: 318161:SDEN_RS13300
uniprot id: Q12L44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Periplasm
messages: Secreted

318161:SDEN RS11720
gene id: 318161:SDEN_RS11720
uniprot id: Q12LY8
names: Similarity
messages: Belongs to the aerolysin family.

318161:SDEN RS11580
gene id: 318161:SDEN_RS11580
uniprot id: Q12M16
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS00965
gene id: 318161:SDEN_RS00965
uniprot id: Q12SV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

318161:SDEN RS01765
gene id: 318161:SDEN_RS01765
uniprot id: Q12SE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

318161:SDEN RS05370
gene id: 318161:SDEN_RS05370
uniprot id: Q12QF6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

318161:SDEN RS00640
gene id: 318161:SDEN_RS00640
uniprot id: Q12T05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS07315
gene id: 318161:SDEN_RS07315
uniprot id: Q12PE3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase T family.
messages: Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.
messages: Homodimer.
messages: Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.

318161:SDEN RS16505
gene id: 318161:SDEN_RS16505
uniprot id: Q12JC5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

318161:SDEN RS06275
gene id: 318161:SDEN_RS06275
uniprot id: Q12PY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

318161:SDEN RS00645
gene id: 318161:SDEN_RS00645
uniprot id: Q12T04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP H family.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS14260
gene id: 318161:SDEN_RS14260
uniprot id: Q12KK4
names: Similarity
messages: Belongs to the TrpR family.

318161:SDEN RS17835
gene id: 318161:SDEN_RS17835
uniprot id: Q12IL6
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

318161:SDEN RS13270
gene id: 318161:SDEN_RS13270
uniprot id: Q12L50
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS09310
gene id: 318161:SDEN_RS09310
uniprot id: Q12NA4
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

318161:SDEN RS19490
gene id: 318161:SDEN_RS19490
uniprot id: Q12HQ6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS10825
gene id: 318161:SDEN_RS10825
uniprot id: Q12MG6
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

318161:SDEN RS05615
gene id: 318161:SDEN_RS05615
uniprot id: Q12QB1
names: Subcellular Location Annotation
messages: Membrane

318161:SDEN RS00620
gene id: 318161:SDEN_RS00620
uniprot id: Q12T09
names: Similarity
messages: Belongs to the GSP C family.

318161:SDEN RS15695
gene id: 318161:SDEN_RS15695
uniprot id: Q12JT0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

318161:SDEN RS13625
gene id: 318161:SDEN_RS13625
uniprot id: Q12KX9
names: Similarity
messages: Belongs to the Gfa family.

318161:SDEN RS00950
gene id: 318161:SDEN_RS00950
uniprot id: Q12SV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

318161:SDEN RS06145
gene id: 318161:SDEN_RS06145
uniprot id: Q12Q08
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

318161:SDEN RS03005
gene id: 318161:SDEN_RS03005
uniprot id: Q12RR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.

318161:SDEN RS16495
gene id: 318161:SDEN_RS16495
uniprot id: Q12JC7
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

318161:SDEN RS15955
gene id: 318161:SDEN_RS15955
uniprot id: Q12JN1
names: Similarity
messages: Belongs to the peptidase U62 family.

318161:SDEN RS05260
gene id: 318161:SDEN_RS05260
uniprot id: Q12QH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

318161:SDEN RS18765
gene id: 318161:SDEN_RS18765
uniprot id: Q12I41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmJ family.
messages: Cytoplasm
messages: Specifically methylates the guanosine in position 1516 of 16S rRNA.

318161:SDEN RS04460
gene id: 318161:SDEN_RS04460
uniprot id: Q12QY3
names: Function
names: Similarity
messages: Belongs to the transpeptidase family. MrdA subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall.

318161:SDEN RS12010
gene id: 318161:SDEN_RS12010
uniprot id: Q12LT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

318161:SDEN RS03355
gene id: 318161:SDEN_RS03355
uniprot id: Q12RJ4
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

318161:SDEN RS01860
gene id: 318161:SDEN_RS01860
uniprot id: Q12SC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

318161:SDEN RS06915
gene id: 318161:SDEN_RS06915
uniprot id: Q12PL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

318161:SDEN RS11970
gene id: 318161:SDEN_RS11970
uniprot id: Q12LT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS02345
gene id: 318161:SDEN_RS02345
uniprot id: Q12S40
names: Function
names: Similarity
names: Subunit
messages: Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.
messages: Belongs to the transcriptional regulatory Fis family.
messages: Homodimer.

318161:SDEN RS07705
gene id: 318161:SDEN_RS07705
uniprot id: Q12P69
names: Function
names: Similarity
messages: Belongs to the nucleoside phosphorylase PpnP family.
messages: Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.

318161:SDEN RS07835
gene id: 318161:SDEN_RS07835
uniprot id: Q12P44
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

318161:SDEN RS00655
gene id: 318161:SDEN_RS00655
uniprot id: Q12T02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP J family.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS00925
gene id: 318161:SDEN_RS00925
uniprot id: Q12SV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

318161:SDEN RS12590
gene id: 318161:SDEN_RS12590
uniprot id: Q12LG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS07945
gene id: 318161:SDEN_RS07945
uniprot id: Q12P21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell inner membrane
messages: Membrane

318161:SDEN RS13980
gene id: 318161:SDEN_RS13980
uniprot id: Q12KQ8
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

318161:SDEN RS14570
gene id: 318161:SDEN_RS14570
uniprot id: Q12KE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

318161:SDEN RS00860
gene id: 318161:SDEN_RS00860
uniprot id: Q12SX1
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

318161:SDEN RS09410
gene id: 318161:SDEN_RS09410
uniprot id: Q12N87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dsrC/tusE family.
messages: Cytoplasm
messages: Part of a sulfur-relay system.

318161:SDEN RS09845
gene id: 318161:SDEN_RS09845
uniprot id: Q12N07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

318161:SDEN RS12510
gene id: 318161:SDEN_RS12510
uniprot id: Q12LI6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homohexamer.
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

318161:SDEN RS11975
gene id: 318161:SDEN_RS11975
uniprot id: Q12LT7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

318161:SDEN RS12980
gene id: 318161:SDEN_RS12980
uniprot id: Q12L93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

318161:SDEN RS07625
gene id: 318161:SDEN_RS07625
uniprot id: Q12P85
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

318161:SDEN RS16565
gene id: 318161:SDEN_RS16565
uniprot id: Q12JB3
names: Similarity
messages: Belongs to the UPF0270 family.

318161:SDEN RS19040
gene id: 318161:SDEN_RS19040
uniprot id: Q12HY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Membrane

318161:SDEN RS02460
gene id: 318161:SDEN_RS02460
uniprot id: Q12S17
names: Similarity
messages: Belongs to the Rsd/AlgQ family.

318161:SDEN RS02420
gene id: 318161:SDEN_RS02420
uniprot id: Q12S25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC1 family. UbiB subfamily.
messages: Cell inner membrane
messages: Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.

318161:SDEN RS17600
gene id: 318161:SDEN_RS17600
uniprot id: Q12IR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP E family.
messages: Cytoplasm

318161:SDEN RS09125
gene id: 318161:SDEN_RS09125
uniprot id: Q12NE2
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

318161:SDEN RS14020
gene id: 318161:SDEN_RS14020
uniprot id: Q12KQ0
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

318161:SDEN RS13525
gene id: 318161:SDEN_RS13525
uniprot id: Q12KZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapF family.
messages: Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

318161:SDEN RS15005
gene id: 318161:SDEN_RS15005
uniprot id: Q12K62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptD family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptE and LptA.
messages: Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.

318161:SDEN RS00880
gene id: 318161:SDEN_RS00880
uniprot id: Q12SW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

318161:SDEN RS01640
gene id: 318161:SDEN_RS01640
uniprot id: Q12SH1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

318161:SDEN RS01045
gene id: 318161:SDEN_RS01045
uniprot id: Q12ST3
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

318161:SDEN RS06535
gene id: 318161:SDEN_RS06535
uniprot id: Q12PT7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

318161:SDEN RS02810
gene id: 318161:SDEN_RS02810
uniprot id: Q12RU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
messages: Interacts with the RNAP. Has a higher affinity for the core RNAP than for the holoenzyme. Its ATPase activity is stimulated by binding to RNAP.
messages: Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair.

318161:SDEN RS12730
gene id: 318161:SDEN_RS12730
uniprot id: Q12LE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

318161:SDEN RS08595
gene id: 318161:SDEN_RS08595
uniprot id: Q12NP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

318161:SDEN RS03520
gene id: 318161:SDEN_RS03520
uniprot id: Q12RF9
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

318161:SDEN RS02405
gene id: 318161:SDEN_RS02405
uniprot id: Q12S28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

318161:SDEN RS04455
gene id: 318161:SDEN_RS04455
uniprot id: Q12QY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

318161:SDEN RS11955
gene id: 318161:SDEN_RS11955
uniprot id: Q12LU1
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

318161:SDEN RS13455
gene id: 318161:SDEN_RS13455
uniprot id: Q12L13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

318161:SDEN RS08660
gene id: 318161:SDEN_RS08660
uniprot id: Q12NN1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

318161:SDEN RS13990
gene id: 318161:SDEN_RS13990
uniprot id: Q12KQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

318161:SDEN RS09135
gene id: 318161:SDEN_RS09135
uniprot id: Q12NE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

318161:SDEN RS02025
gene id: 318161:SDEN_RS02025
uniprot id: Q12S99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

318161:SDEN RS10730
gene id: 318161:SDEN_RS10730
uniprot id: Q12MI6
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

318161:SDEN RS07895
gene id: 318161:SDEN_RS07895
uniprot id: Q12P31
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

318161:SDEN RS10890
gene id: 318161:SDEN_RS10890
uniprot id: Q12MF4
names: Subunit
messages: Monomer.

318161:SDEN RS01885
gene id: 318161:SDEN_RS01885
uniprot id: Q12SC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

318161:SDEN RS00915
gene id: 318161:SDEN_RS00915
uniprot id: Q12SW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

318161:SDEN RS18870
gene id: 318161:SDEN_RS18870
uniprot id: Q12I20
names: Similarity
messages: Belongs to the MotB family.

318161:SDEN RS07375
gene id: 318161:SDEN_RS07375
uniprot id: Q12PD1
names: Similarity
messages: Belongs to the peptidase S8 family.

318161:SDEN RS01030
gene id: 318161:SDEN_RS01030
uniprot id: Q12ST6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

318161:SDEN RS08030
gene id: 318161:SDEN_RS08030
uniprot id: Q12P04
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

318161:SDEN RS12130
gene id: 318161:SDEN_RS12130
uniprot id: Q12LQ7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

318161:SDEN RS00550
gene id: 318161:SDEN_RS00550
uniprot id: Q12T23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

318161:SDEN RS00120
gene id: 318161:SDEN_RS00120
uniprot id: Q12TA5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.