312153:PNUC RS01205
gene id: 312153:PNUC_RS01205
uniprot id: A4SVD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

312153:PNUC RS00980
gene id: 312153:PNUC_RS00980
uniprot id: A4SV89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapD family.
messages: Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
messages: Cytoplasm
messages: Interacts with FtsZ.

312153:PNUC RS10775
gene id: 312153:PNUC_RS10775
uniprot id: A4T0M7
names: Similarity
messages: Belongs to the DprA/Smf family.

312153:PNUC RS09285
gene id: 312153:PNUC_RS09285
uniprot id: A4SZT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

312153:PNUC RS00685
gene id: 312153:PNUC_RS00685
uniprot id: A4SV33
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

312153:PNUC RS08740
gene id: 312153:PNUC_RS08740
uniprot id: A4SZH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

312153:PNUC RS00635
gene id: 312153:PNUC_RS00635
uniprot id: A4SV24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

312153:PNUC RS00405
gene id: 312153:PNUC_RS00405
uniprot id: A4SUX9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

312153:PNUC RS09245
gene id: 312153:PNUC_RS09245
uniprot id: A4SZS9
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

312153:PNUC RS00810
gene id: 312153:PNUC_RS00810
uniprot id: A4SV56
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

312153:PNUC RS02700
gene id: 312153:PNUC_RS02700
uniprot id: A4SW74
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

312153:PNUC RS03870
gene id: 312153:PNUC_RS03870
uniprot id: A4SWU5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

312153:PNUC RS08250
gene id: 312153:PNUC_RS08250
uniprot id: A4SZ82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

312153:PNUC RS02220
gene id: 312153:PNUC_RS02220
uniprot id: A4SVX9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

312153:PNUC RS10050
gene id: 312153:PNUC_RS10050
uniprot id: A4T087
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

312153:PNUC RS04295
gene id: 312153:PNUC_RS04295
uniprot id: A4SX30
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

312153:PNUC RS09190
gene id: 312153:PNUC_RS09190
uniprot id: A4SZR8
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

312153:PNUC RS04805
gene id: 312153:PNUC_RS04805
uniprot id: A4SXC5
names: Subcellular Location Annotation
messages: Cytoplasm

312153:PNUC RS00315
gene id: 312153:PNUC_RS00315
uniprot id: A4SUW1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

312153:PNUC RS00395
gene id: 312153:PNUC_RS00395
uniprot id: A4SUX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

312153:PNUC RS10125
gene id: 312153:PNUC_RS10125
uniprot id: A4T0A2
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

312153:PNUC RS04940
gene id: 312153:PNUC_RS04940
uniprot id: A4SXF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsB family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

312153:PNUC RS05455
gene id: 312153:PNUC_RS05455
uniprot id: A4SXP7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 75 kDa subunit family.
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

312153:PNUC RS03965
gene id: 312153:PNUC_RS03965
uniprot id: A4SWW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

312153:PNUC RS09860
gene id: 312153:PNUC_RS09860
uniprot id: A4T050
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm
messages: Homodimer.

312153:PNUC RS00325
gene id: 312153:PNUC_RS00325
uniprot id: A4SUW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

312153:PNUC RS04110
gene id: 312153:PNUC_RS04110
uniprot id: A4SWZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

312153:PNUC RS03595
gene id: 312153:PNUC_RS03595
uniprot id: A4SWP3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

312153:PNUC RS01020
gene id: 312153:PNUC_RS01020
uniprot id: A4SV97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

312153:PNUC RS10785
gene id: 312153:PNUC_RS10785
uniprot id: A4T0N0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

312153:PNUC RS07570
gene id: 312153:PNUC_RS07570
uniprot id: A4SYU7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

312153:PNUC RS04050
gene id: 312153:PNUC_RS04050
uniprot id: A4SWY1
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS08955
gene id: 312153:PNUC_RS08955
uniprot id: A4SZM1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

312153:PNUC RS08490
gene id: 312153:PNUC_RS08490
uniprot id: A4SZD1
names: Similarity
messages: Belongs to the hyi family.

312153:PNUC RS03245
gene id: 312153:PNUC_RS03245
uniprot id: A4SWH5
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS05230
gene id: 312153:PNUC_RS05230
uniprot id: A4SXK4
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.

312153:PNUC RS05315
gene id: 312153:PNUC_RS05315
uniprot id: A4SXL9
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

312153:PNUC RS00915
gene id: 312153:PNUC_RS00915
uniprot id: A4SV76
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

312153:PNUC RS06685
gene id: 312153:PNUC_RS06685
uniprot id: A4SYC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

312153:PNUC RS10615
gene id: 312153:PNUC_RS10615
uniprot id: A4T0J9
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

312153:PNUC RS06755
gene id: 312153:PNUC_RS06755
uniprot id: A4SYD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamB family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

312153:PNUC RS01560
gene id: 312153:PNUC_RS01560
uniprot id: A4SVK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the high-potential iron-sulfur protein (HiPIP) family.
messages: Homodimer.
messages: Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria.

312153:PNUC RS04000
gene id: 312153:PNUC_RS04000
uniprot id: A4SWX1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS00270
gene id: 312153:PNUC_RS00270
uniprot id: A4SUV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

312153:PNUC RS10305
gene id: 312153:PNUC_RS10305
uniprot id: A4T0D8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

312153:PNUC RS04335
gene id: 312153:PNUC_RS04335
uniprot id: A4SX37
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

312153:PNUC RS10085
gene id: 312153:PNUC_RS10085
uniprot id: A4T094
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

312153:PNUC RS01630
gene id: 312153:PNUC_RS01630
uniprot id: A4SVL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

312153:PNUC RS01000
gene id: 312153:PNUC_RS01000
uniprot id: A4SV93
names: Similarity
messages: Belongs to the GSP E family.

312153:PNUC RS05440
gene id: 312153:PNUC_RS05440
uniprot id: A4SXP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

312153:PNUC RS00995
gene id: 312153:PNUC_RS00995
uniprot id: A4SV92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

312153:PNUC RS09080
gene id: 312153:PNUC_RS09080
uniprot id: A4SZP6
names: Function
messages: Might have a role analogous to that of eukaryotic histone proteins.

312153:PNUC RS09055
gene id: 312153:PNUC_RS09055
uniprot id: A4SZP1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS09170
gene id: 312153:PNUC_RS09170
uniprot id: A4SZR4
names: Function
names: Similarity
messages: Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

312153:PNUC RS08405
gene id: 312153:PNUC_RS08405
uniprot id: A4SZB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

312153:PNUC RS01435
gene id: 312153:PNUC_RS01435
uniprot id: A4SVH9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

312153:PNUC RS07780
gene id: 312153:PNUC_RS07780
uniprot id: A4SYY8
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

312153:PNUC RS07710
gene id: 312153:PNUC_RS07710
uniprot id: A4SYX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

312153:PNUC RS07400
gene id: 312153:PNUC_RS07400
uniprot id: A4SYR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RlmJ family.
messages: Monomer.
messages: Specifically methylates the adenine in position 2030 of 23S rRNA.

312153:PNUC RS06780
gene id: 312153:PNUC_RS06780
uniprot id: A4SYE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

312153:PNUC RS09695
gene id: 312153:PNUC_RS09695
uniprot id: A4T017
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

312153:PNUC RS03600
gene id: 312153:PNUC_RS03600
uniprot id: A4SWP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif.
messages: Membrane

312153:PNUC RS09315
gene id: 312153:PNUC_RS09315
uniprot id: A4SZU3
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

312153:PNUC RS04860
gene id: 312153:PNUC_RS04860
uniprot id: A4SXD5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

312153:PNUC RS05465
gene id: 312153:PNUC_RS05465
uniprot id: A4SXP9
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

312153:PNUC RS03485
gene id: 312153:PNUC_RS03485
uniprot id: A4SWM3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

312153:PNUC RS00135
gene id: 312153:PNUC_RS00135
uniprot id: A4SUT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

312153:PNUC RS06995
gene id: 312153:PNUC_RS06995
uniprot id: A4SYI4
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS06305
gene id: 312153:PNUC_RS06305
uniprot id: A4SY51
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS09880
gene id: 312153:PNUC_RS09880
uniprot id: A4T054
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.

312153:PNUC RS06815
gene id: 312153:PNUC_RS06815
uniprot id: A4SYF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

312153:PNUC RS01140
gene id: 312153:PNUC_RS01140
uniprot id: A4SVC0
names: Function
names: Similarity
messages: Belongs to the MurCDEF family. Mpl subfamily.
messages: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.

312153:PNUC RS07580
gene id: 312153:PNUC_RS07580
uniprot id: A4SYU9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS08440
gene id: 312153:PNUC_RS08440
uniprot id: A4SZC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

312153:PNUC RS06195
gene id: 312153:PNUC_RS06195
uniprot id: A4SY30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

312153:PNUC RS08970
gene id: 312153:PNUC_RS08970
uniprot id: A4SZM4
names: Caution
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

312153:PNUC RS05625
gene id: 312153:PNUC_RS05625
uniprot id: A4SXS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

312153:PNUC RS02490
gene id: 312153:PNUC_RS02490
uniprot id: A4SW32
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

312153:PNUC RS05100
gene id: 312153:PNUC_RS05100
uniprot id: A4SXH9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

312153:PNUC RS00305
gene id: 312153:PNUC_RS00305
uniprot id: A4SUU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

312153:PNUC RS07445
gene id: 312153:PNUC_RS07445
uniprot id: A4SYS2
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

312153:PNUC RS07575
gene id: 312153:PNUC_RS07575
uniprot id: A4SYU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

312153:PNUC RS10500
gene id: 312153:PNUC_RS10500
uniprot id: A4T0H7
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

312153:PNUC RS00260
gene id: 312153:PNUC_RS00260
uniprot id: A4SUV0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

312153:PNUC RS08115
gene id: 312153:PNUC_RS08115
uniprot id: A4SZ55
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

312153:PNUC RS00365
gene id: 312153:PNUC_RS00365
uniprot id: A4SUX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

312153:PNUC RS00015
gene id: 312153:PNUC_RS00015
uniprot id: A4SUR1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

312153:PNUC RS07750
gene id: 312153:PNUC_RS07750
uniprot id: A4SYY2
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

312153:PNUC RS06235
gene id: 312153:PNUC_RS06235
uniprot id: A4SY38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

312153:PNUC RS09125
gene id: 312153:PNUC_RS09125
uniprot id: A4SZQ5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

312153:PNUC RS07785
gene id: 312153:PNUC_RS07785
uniprot id: A4SYY9
names: Function
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.

312153:PNUC RS09945
gene id: 312153:PNUC_RS09945
uniprot id: A4T067
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

312153:PNUC RS06620
gene id: 312153:PNUC_RS06620
uniprot id: A4SYB2
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.

312153:PNUC RS10355
gene id: 312153:PNUC_RS10355
uniprot id: A4T0E8
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

312153:PNUC RS09160
gene id: 312153:PNUC_RS09160
uniprot id: A4SZR2
names: Similarity
messages: Belongs to the DnaA family.

312153:PNUC RS00370
gene id: 312153:PNUC_RS00370
uniprot id: A4SUX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

312153:PNUC RS02465
gene id: 312153:PNUC_RS02465
uniprot id: A4SW27
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

312153:PNUC RS06285
gene id: 312153:PNUC_RS06285
uniprot id: A4SY47
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

312153:PNUC RS07720
gene id: 312153:PNUC_RS07720
uniprot id: A4SYX6
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

312153:PNUC RS02525
gene id: 312153:PNUC_RS02525
uniprot id: A4SW39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

312153:PNUC RS08870
gene id: 312153:PNUC_RS08870
uniprot id: A4SZK4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

312153:PNUC RS08670
gene id: 312153:PNUC_RS08670
uniprot id: A4SZG6
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS07425
gene id: 312153:PNUC_RS07425
uniprot id: A4SYR8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS06665
gene id: 312153:PNUC_RS06665
uniprot id: A4SYC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

312153:PNUC RS08500
gene id: 312153:PNUC_RS08500
uniprot id: A4SZD3
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

312153:PNUC RS06440
gene id: 312153:PNUC_RS06440
uniprot id: A4SY77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

312153:PNUC RS01215
gene id: 312153:PNUC_RS01215
uniprot id: A4SVD5
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

312153:PNUC RS04910
gene id: 312153:PNUC_RS04910
uniprot id: A4SXE4
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

312153:PNUC RS07465
gene id: 312153:PNUC_RS07465
uniprot id: A4SYS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

312153:PNUC RS03670
gene id: 312153:PNUC_RS03670
uniprot id: A4SWQ6
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

312153:PNUC RS09150
gene id: 312153:PNUC_RS09150
uniprot id: A4SZR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

312153:PNUC RS07970
gene id: 312153:PNUC_RS07970
uniprot id: A4SZ26
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

312153:PNUC RS04835
gene id: 312153:PNUC_RS04835
uniprot id: A4SXD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

312153:PNUC RS09175
gene id: 312153:PNUC_RS09175
uniprot id: A4SZR5
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

312153:PNUC RS02660
gene id: 312153:PNUC_RS02660
uniprot id: A4SW66
names: Similarity
messages: Belongs to the histone deacetylase family.

312153:PNUC RS03995
gene id: 312153:PNUC_RS03995
uniprot id: A4SWX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

312153:PNUC RS07895
gene id: 312153:PNUC_RS07895
uniprot id: A4SZ11
names: Function
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Possible subunit of a heme lyase.

312153:PNUC RS03160
gene id: 312153:PNUC_RS03160
uniprot id: A4SWF9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

312153:PNUC RS09870
gene id: 312153:PNUC_RS09870
uniprot id: A4T052
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS00380
gene id: 312153:PNUC_RS00380
uniprot id: A4SUX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

312153:PNUC RS09370
gene id: 312153:PNUC_RS09370
uniprot id: A4SZV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

312153:PNUC RS08175
gene id: 312153:PNUC_RS08175
uniprot id: A4SZ67
names: Similarity
messages: Belongs to the hyi family.

312153:PNUC RS02435
gene id: 312153:PNUC_RS02435
uniprot id: A4SW21
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

312153:PNUC RS08325
gene id: 312153:PNUC_RS08325
uniprot id: A4SZ97
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

312153:PNUC RS05075
gene id: 312153:PNUC_RS05075
uniprot id: A4SXH4
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

312153:PNUC RS07070
gene id: 312153:PNUC_RS07070
uniprot id: A4SYJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

312153:PNUC RS03785
gene id: 312153:PNUC_RS03785
uniprot id: A4SWS8
names: Similarity
messages: Belongs to the UxaA family.

312153:PNUC RS01125
gene id: 312153:PNUC_RS01125
uniprot id: A4SVB7
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

312153:PNUC RS06275
gene id: 312153:PNUC_RS06275
uniprot id: A4SY45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

312153:PNUC RS02210
gene id: 312153:PNUC_RS02210
uniprot id: A4SVX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PriB family.
messages: Binds single-stranded DNA at the primosome assembly site (PAS).
messages: Component of the preprimosomal complex composed of PriA, PriB, PriC, DnaB and DnaT. Upon transient interaction with DnaG it forms the primosome.

312153:PNUC RS00375
gene id: 312153:PNUC_RS00375
uniprot id: A4SUX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

312153:PNUC RS00925
gene id: 312153:PNUC_RS00925
uniprot id: A4SV78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

312153:PNUC RS04440
gene id: 312153:PNUC_RS04440
uniprot id: A4SX58
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

312153:PNUC RS08350
gene id: 312153:PNUC_RS08350
uniprot id: A4SZA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PstS family.
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

312153:PNUC RS03930
gene id: 312153:PNUC_RS03930
uniprot id: A4SWV7
names: Similarity
messages: Belongs to the UPF0246 family.

312153:PNUC RS04990
gene id: 312153:PNUC_RS04990
uniprot id: A4SXF7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

312153:PNUC RS09425
gene id: 312153:PNUC_RS09425
uniprot id: A4SZW5
names: Similarity
messages: Belongs to the pyruvate kinase family.

312153:PNUC RS07260
gene id: 312153:PNUC_RS07260
uniprot id: A4SYN6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

312153:PNUC RS10100
gene id: 312153:PNUC_RS10100
uniprot id: A4T097
names: Similarity
messages: Belongs to the peptidase S41A family.

312153:PNUC RS01985
gene id: 312153:PNUC_RS01985
uniprot id: A4SVT4
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

312153:PNUC RS04540
gene id: 312153:PNUC_RS04540
uniprot id: A4SX75
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

312153:PNUC RS05515
gene id: 312153:PNUC_RS05515
uniprot id: A4SXQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

312153:PNUC RS04840
gene id: 312153:PNUC_RS04840
uniprot id: A4SXD2
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

312153:PNUC RS09070
gene id: 312153:PNUC_RS09070
uniprot id: A4SZP4
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS03985
gene id: 312153:PNUC_RS03985
uniprot id: A4SWW8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

312153:PNUC RS07600
gene id: 312153:PNUC_RS07600
uniprot id: A4SYV3
names: Activity Regulation
names: Caution
names: Domain
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

312153:PNUC RS06000
gene id: 312153:PNUC_RS06000
uniprot id: A4SXZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

312153:PNUC RS07355
gene id: 312153:PNUC_RS07355
uniprot id: A4SYQ4
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS07505
gene id: 312153:PNUC_RS07505
uniprot id: A4SYT4
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

312153:PNUC RS00620
gene id: 312153:PNUC_RS00620
uniprot id: A4SV21
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

312153:PNUC RS06520
gene id: 312153:PNUC_RS06520
uniprot id: A4SY93
names: Similarity
messages: Belongs to the PrpD family.

312153:PNUC RS02150
gene id: 312153:PNUC_RS02150
uniprot id: A4SVW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
messages: Cytoplasm
messages: Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.

312153:PNUC RS10360
gene id: 312153:PNUC_RS10360
uniprot id: A4T0E9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

312153:PNUC RS02760
gene id: 312153:PNUC_RS02760
uniprot id: A4SW86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

312153:PNUC RS10230
gene id: 312153:PNUC_RS10230
uniprot id: A4T0C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

312153:PNUC RS05365
gene id: 312153:PNUC_RS05365
uniprot id: A4SXM9
names: Function
names: Subunit
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

312153:PNUC RS09995
gene id: 312153:PNUC_RS09995
uniprot id: A4T076
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

312153:PNUC RS08055
gene id: 312153:PNUC_RS08055
uniprot id: A4SZ43
names: Similarity
messages: Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family.

312153:PNUC RS02085
gene id: 312153:PNUC_RS02085
uniprot id: A4SVV4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

312153:PNUC RS06720
gene id: 312153:PNUC_RS06720
uniprot id: A4SYD1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

312153:PNUC RS02365
gene id: 312153:PNUC_RS02365
uniprot id: A4SW07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

312153:PNUC RS01095
gene id: 312153:PNUC_RS01095
uniprot id: A4SVB2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

312153:PNUC RS09825
gene id: 312153:PNUC_RS09825
uniprot id: A4T043
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiJ family.
messages: Cytoplasm
messages: Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.

312153:PNUC RS04030
gene id: 312153:PNUC_RS04030
uniprot id: A4SWX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

312153:PNUC RS06860
gene id: 312153:PNUC_RS06860
uniprot id: A4SYF8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS06445
gene id: 312153:PNUC_RS06445
uniprot id: A4SY78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

312153:PNUC RS06460
gene id: 312153:PNUC_RS06460
uniprot id: A4SY81
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

312153:PNUC RS01265
gene id: 312153:PNUC_RS01265
uniprot id: A4SVE5
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

312153:PNUC RS00145
gene id: 312153:PNUC_RS00145
uniprot id: A4SUT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

312153:PNUC RS10095
gene id: 312153:PNUC_RS10095
uniprot id: A4T096
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Homodimer.

312153:PNUC RS06745
gene id: 312153:PNUC_RS06745
uniprot id: A4SYD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

312153:PNUC RS09865
gene id: 312153:PNUC_RS09865
uniprot id: A4T051
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

312153:PNUC RS09495
gene id: 312153:PNUC_RS09495
uniprot id: A4SZX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

312153:PNUC RS03630
gene id: 312153:PNUC_RS03630
uniprot id: A4SWP9
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

312153:PNUC RS09685
gene id: 312153:PNUC_RS09685
uniprot id: A4T015
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

312153:PNUC RS05630
gene id: 312153:PNUC_RS05630
uniprot id: A4SXT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

312153:PNUC RS04200
gene id: 312153:PNUC_RS04200
uniprot id: A4SX11
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

312153:PNUC RS00740
gene id: 312153:PNUC_RS00740
uniprot id: A4SV43
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

312153:PNUC RS09035
gene id: 312153:PNUC_RS09035
uniprot id: A4SZN7
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

312153:PNUC RS02195
gene id: 312153:PNUC_RS02195
uniprot id: A4SVX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

312153:PNUC RS03455
gene id: 312153:PNUC_RS03455
uniprot id: A4SWL7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.

312153:PNUC RS07800
gene id: 312153:PNUC_RS07800
uniprot id: A4SYZ2
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

312153:PNUC RS07385
gene id: 312153:PNUC_RS07385
uniprot id: A4SYR0
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS08745
gene id: 312153:PNUC_RS08745
uniprot id: A4SZI0
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

312153:PNUC RS06050
gene id: 312153:PNUC_RS06050
uniprot id: A4SY02
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

312153:PNUC RS06905
gene id: 312153:PNUC_RS06905
uniprot id: A4SYG7
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS08925
gene id: 312153:PNUC_RS08925
uniprot id: A4SZL5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

312153:PNUC RS02045
gene id: 312153:PNUC_RS02045
uniprot id: A4SVU6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

312153:PNUC RS09130
gene id: 312153:PNUC_RS09130
uniprot id: A4SZQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

312153:PNUC RS09000
gene id: 312153:PNUC_RS09000
uniprot id: A4SZN0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

312153:PNUC RS02240
gene id: 312153:PNUC_RS02240
uniprot id: A4SVY3
names: Similarity
messages: Belongs to the peptidase C40 family.

312153:PNUC RS09665
gene id: 312153:PNUC_RS09665
uniprot id: A4T011
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

312153:PNUC RS00100
gene id: 312153:PNUC_RS00100
uniprot id: A4SUS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

312153:PNUC RS01965
gene id: 312153:PNUC_RS01965
uniprot id: A4SVT1
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

312153:PNUC RS09835
gene id: 312153:PNUC_RS09835
uniprot id: A4T045
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

312153:PNUC RS07820
gene id: 312153:PNUC_RS07820
uniprot id: A4SYZ6
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

312153:PNUC RS07025
gene id: 312153:PNUC_RS07025
uniprot id: A4SYJ0
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

312153:PNUC RS09415
gene id: 312153:PNUC_RS09415
uniprot id: A4SZW3
names: Similarity
messages: Belongs to the SAICAR synthetase family.

312153:PNUC RS09730
gene id: 312153:PNUC_RS09730
uniprot id: A4T024
names: Similarity
messages: Belongs to the transcriptional regulatory Fis family.

312153:PNUC RS03665
gene id: 312153:PNUC_RS03665
uniprot id: A4SWQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

312153:PNUC RS01935
gene id: 312153:PNUC_RS01935
uniprot id: A4SVS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Cell outer membrane
messages: Homodimer.
messages: Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.

312153:PNUC RS01590
gene id: 312153:PNUC_RS01590
uniprot id: A4SVK9
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS01190
gene id: 312153:PNUC_RS01190
uniprot id: A4SVD0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

312153:PNUC RS07380
gene id: 312153:PNUC_RS07380
uniprot id: A4SYQ9
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS05995
gene id: 312153:PNUC_RS05995
uniprot id: A4SXZ2
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

312153:PNUC RS01075
gene id: 312153:PNUC_RS01075
uniprot id: A4SVA8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

312153:PNUC RS05950
gene id: 312153:PNUC_RS05950
uniprot id: A4SXY5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

312153:PNUC RS00745
gene id: 312153:PNUC_RS00745
uniprot id: A4SV44
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

312153:PNUC RS01345
gene id: 312153:PNUC_RS01345
uniprot id: A4SVG1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

312153:PNUC RS03980
gene id: 312153:PNUC_RS03980
uniprot id: A4SWW7
names: Similarity
messages: Belongs to the citrate synthase family.

312153:PNUC RS09850
gene id: 312153:PNUC_RS09850
uniprot id: A4T048
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

312153:PNUC RS05280
gene id: 312153:PNUC_RS05280
uniprot id: A4SXL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

312153:PNUC RS07220
gene id: 312153:PNUC_RS07220
uniprot id: A4SYM8
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

312153:PNUC RS06485
gene id: 312153:PNUC_RS06485
uniprot id: A4SY86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

312153:PNUC RS02105
gene id: 312153:PNUC_RS02105
uniprot id: A4SVV8
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

312153:PNUC RS07455
gene id: 312153:PNUC_RS07455
uniprot id: A4SYS4
names: Similarity
messages: Belongs to the UPF0125 (RnfH) family.

312153:PNUC RS08890
gene id: 312153:PNUC_RS08890
uniprot id: A4SZK8
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS10220
gene id: 312153:PNUC_RS10220
uniprot id: A4T0C1
names: Similarity
messages: Belongs to the CFA/CMAS family.

312153:PNUC RS03605
gene id: 312153:PNUC_RS03605
uniprot id: A4SWP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolA family.
messages: Monomer.
messages: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
messages: Periplasm

312153:PNUC RS03095
gene id: 312153:PNUC_RS03095
uniprot id: A4SWE7
names: Similarity
messages: Belongs to the KdgT transporter family.

312153:PNUC RS02055
gene id: 312153:PNUC_RS02055
uniprot id: A4SVU8
names: Similarity
messages: Belongs to the peptidase S49 family.

312153:PNUC RS10390
gene id: 312153:PNUC_RS10390
uniprot id: A4T0F5
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

312153:PNUC RS05710
gene id: 312153:PNUC_RS05710
uniprot id: A4SXU4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

312153:PNUC RS03895
gene id: 312153:PNUC_RS03895
uniprot id: A4SWV0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

312153:PNUC RS04850
gene id: 312153:PNUC_RS04850
uniprot id: A4SXD4
names: Similarity
messages: Belongs to the nitroreductase family. HadB/RutE subfamily.

312153:PNUC RS05770
gene id: 312153:PNUC_RS05770
uniprot id: A4SXV6
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

312153:PNUC RS10450
gene id: 312153:PNUC_RS10450
uniprot id: A4T0G7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

312153:PNUC RS09725
gene id: 312153:PNUC_RS09725
uniprot id: A4T023
names: Function
names: Similarity
messages: Belongs to the Dus family. DusB subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

312153:PNUC RS08865
gene id: 312153:PNUC_RS08865
uniprot id: A4SZK3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS07410
gene id: 312153:PNUC_RS07410
uniprot id: A4SYR5
names: Similarity
messages: Belongs to the peptidase S66 family.

312153:PNUC RS05035
gene id: 312153:PNUC_RS05035
uniprot id: A4SXG6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

312153:PNUC RS03035
gene id: 312153:PNUC_RS03035
uniprot id: A4SWD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

312153:PNUC RS03840
gene id: 312153:PNUC_RS03840
uniprot id: A4SWT9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

312153:PNUC RS00470
gene id: 312153:PNUC_RS00470
uniprot id: A4SUZ1
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

312153:PNUC RS09375
gene id: 312153:PNUC_RS09375
uniprot id: A4SZV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

312153:PNUC RS10300
gene id: 312153:PNUC_RS10300
uniprot id: A4T0D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

312153:PNUC RS02375
gene id: 312153:PNUC_RS02375
uniprot id: A4SW09
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

312153:PNUC RS05080
gene id: 312153:PNUC_RS05080
uniprot id: A4SXH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YciB family.
messages: Cell inner membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.

312153:PNUC RS01170
gene id: 312153:PNUC_RS01170
uniprot id: A4SVC6
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

312153:PNUC RS01480
gene id: 312153:PNUC_RS01480
uniprot id: A4SVI8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

312153:PNUC RS02140
gene id: 312153:PNUC_RS02140
uniprot id: A4SVW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

312153:PNUC RS09775
gene id: 312153:PNUC_RS09775
uniprot id: A4T033
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

312153:PNUC RS07520
gene id: 312153:PNUC_RS07520
uniprot id: A4SYT7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

312153:PNUC RS09745
gene id: 312153:PNUC_RS09745
uniprot id: A4T027
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

312153:PNUC RS00675
gene id: 312153:PNUC_RS00675
uniprot id: A4SV31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

312153:PNUC RS00345
gene id: 312153:PNUC_RS00345
uniprot id: A4SUW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

312153:PNUC RS01340
gene id: 312153:PNUC_RS01340
uniprot id: A4SVG0
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

312153:PNUC RS08290
gene id: 312153:PNUC_RS08290
uniprot id: A4SZ91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Cell inner membrane
messages: Membrane

312153:PNUC RS04100
gene id: 312153:PNUC_RS04100
uniprot id: A4SWZ1
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

312153:PNUC RS00300
gene id: 312153:PNUC_RS00300
uniprot id: A4SUV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

312153:PNUC RS06790
gene id: 312153:PNUC_RS06790
uniprot id: A4SYE5
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.

312153:PNUC RS02535
gene id: 312153:PNUC_RS02535
uniprot id: A4SW41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

312153:PNUC RS09400
gene id: 312153:PNUC_RS09400
uniprot id: A4SZW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

312153:PNUC RS05285
gene id: 312153:PNUC_RS05285
uniprot id: A4SXL3
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

312153:PNUC RS01445
gene id: 312153:PNUC_RS01445
uniprot id: A4SVI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

312153:PNUC RS00080
gene id: 312153:PNUC_RS00080
uniprot id: A4SUS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

312153:PNUC RS05190
gene id: 312153:PNUC_RS05190
uniprot id: A4SXJ6
names: Function
names: Similarity
messages: Belongs to the cyanase family.
messages: Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.

312153:PNUC RS03225
gene id: 312153:PNUC_RS03225
uniprot id: A4SWH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

312153:PNUC RS07590
gene id: 312153:PNUC_RS07590
uniprot id: A4SYV1
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

312153:PNUC RS02015
gene id: 312153:PNUC_RS02015
uniprot id: A4SVU0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

312153:PNUC RS00725
gene id: 312153:PNUC_RS00725
uniprot id: A4SV40
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

312153:PNUC RS06940
gene id: 312153:PNUC_RS06940
uniprot id: A4SYH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

312153:PNUC RS09965
gene id: 312153:PNUC_RS09965
uniprot id: A4T070
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

312153:PNUC RS02620
gene id: 312153:PNUC_RS02620
uniprot id: A4SW58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapB family.
messages: Cell inner membrane
messages: Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.

312153:PNUC RS08990
gene id: 312153:PNUC_RS08990
uniprot id: A4SZM8
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS04935
gene id: 312153:PNUC_RS04935
uniprot id: A4SXE9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

312153:PNUC RS08275
gene id: 312153:PNUC_RS08275
uniprot id: A4SZ87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Membrane

312153:PNUC RS03345
gene id: 312153:PNUC_RS03345
uniprot id: A4SWJ5
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

312153:PNUC RS07180
gene id: 312153:PNUC_RS07180
uniprot id: A4SYM1
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

312153:PNUC RS07620
gene id: 312153:PNUC_RS07620
uniprot id: A4SYV7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

312153:PNUC RS06675
gene id: 312153:PNUC_RS06675
uniprot id: A4SYC2
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS08415
gene id: 312153:PNUC_RS08415
uniprot id: A4SZB6
names: Similarity
messages: Belongs to the MQO family.

312153:PNUC RS01520
gene id: 312153:PNUC_RS01520
uniprot id: A4SVJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

312153:PNUC RS00475
gene id: 312153:PNUC_RS00475
uniprot id: A4SUZ2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

312153:PNUC RS07795
gene id: 312153:PNUC_RS07795
uniprot id: A4SYZ1
names: Similarity
messages: Belongs to the HesB/IscA family.

312153:PNUC RS05495
gene id: 312153:PNUC_RS05495
uniprot id: A4SXQ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

312153:PNUC RS06255
gene id: 312153:PNUC_RS06255
uniprot id: A4SY41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

312153:PNUC RS04375
gene id: 312153:PNUC_RS04375
uniprot id: A4SX44
names: Function
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

312153:PNUC RS00105
gene id: 312153:PNUC_RS00105
uniprot id: A4SUS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

312153:PNUC RS03300
gene id: 312153:PNUC_RS03300
uniprot id: A4SWI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

312153:PNUC RS03860
gene id: 312153:PNUC_RS03860
uniprot id: A4SWU3
names: Similarity
messages: Belongs to the peptidase S11 family.

312153:PNUC RS04690
gene id: 312153:PNUC_RS04690
uniprot id: A4SXA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

312153:PNUC RS06725
gene id: 312153:PNUC_RS06725
uniprot id: A4SYD2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

312153:PNUC RS03835
gene id: 312153:PNUC_RS03835
uniprot id: A4SWT8
names: Function
names: Subunit
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
messages: Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

312153:PNUC RS03945
gene id: 312153:PNUC_RS03945
uniprot id: A4SWW0
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

312153:PNUC RS00515
gene id: 312153:PNUC_RS00515
uniprot id: A4SV00
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

312153:PNUC RS00735
gene id: 312153:PNUC_RS00735
uniprot id: A4SV42
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

312153:PNUC RS09735
gene id: 312153:PNUC_RS09735
uniprot id: A4T025
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

312153:PNUC RS09485
gene id: 312153:PNUC_RS09485
uniprot id: A4SZX7
names: Similarity
messages: Belongs to the N-Me-Phe pilin family.

312153:PNUC RS10160
gene id: 312153:PNUC_RS10160
uniprot id: A4T0A9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

312153:PNUC RS05210
gene id: 312153:PNUC_RS05210
uniprot id: A4SXK0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

312153:PNUC RS10630
gene id: 312153:PNUC_RS10630
uniprot id: A4T0K2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

312153:PNUC RS01385
gene id: 312153:PNUC_RS01385
uniprot id: A4SVG9
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS03500
gene id: 312153:PNUC_RS03500
uniprot id: A4SWM6
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS04925
gene id: 312153:PNUC_RS04925
uniprot id: A4SXE7
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

312153:PNUC RS09325
gene id: 312153:PNUC_RS09325
uniprot id: A4SZU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm

312153:PNUC RS10350
gene id: 312153:PNUC_RS10350
uniprot id: A4T0E7
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

312153:PNUC RS05160
gene id: 312153:PNUC_RS05160
uniprot id: A4SXJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

312153:PNUC RS07555
gene id: 312153:PNUC_RS07555
uniprot id: A4SYU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

312153:PNUC RS10415
gene id: 312153:PNUC_RS10415
uniprot id: A4T0G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

312153:PNUC RS05545
gene id: 312153:PNUC_RS05545
uniprot id: A4SXR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

312153:PNUC RS08095
gene id: 312153:PNUC_RS08095
uniprot id: A4SZ51
names: Function
names: Subunit
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
messages: Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

312153:PNUC RS02880
gene id: 312153:PNUC_RS02880
uniprot id: A4SWA9
names: Similarity
messages: Belongs to the TPP enzyme family.

312153:PNUC RS05660
gene id: 312153:PNUC_RS05660
uniprot id: A4SXT6
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.

312153:PNUC RS07905
gene id: 312153:PNUC_RS07905
uniprot id: A4SZ13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

312153:PNUC RS04875
gene id: 312153:PNUC_RS04875
uniprot id: A4SXD8
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

312153:PNUC RS08485
gene id: 312153:PNUC_RS08485
uniprot id: A4SZD0
names: Similarity
messages: Belongs to the peptidase C56 family.

312153:PNUC RS00445
gene id: 312153:PNUC_RS00445
uniprot id: A4SUY6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

312153:PNUC RS08650
gene id: 312153:PNUC_RS08650
uniprot id: A4SZG2
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS06990
gene id: 312153:PNUC_RS06990
uniprot id: A4SYI3
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

312153:PNUC RS04025
gene id: 312153:PNUC_RS04025
uniprot id: A4SWX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

312153:PNUC RS03405
gene id: 312153:PNUC_RS03405
uniprot id: A4SWK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

312153:PNUC RS09045
gene id: 312153:PNUC_RS09045
uniprot id: A4SZN9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

312153:PNUC RS01585
gene id: 312153:PNUC_RS01585
uniprot id: A4SVK8
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

312153:PNUC RS09920
gene id: 312153:PNUC_RS09920
uniprot id: A4T062
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

312153:PNUC RS07530
gene id: 312153:PNUC_RS07530
uniprot id: A4SYT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

312153:PNUC RS03290
gene id: 312153:PNUC_RS03290
uniprot id: A4SWI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

312153:PNUC RS03375
gene id: 312153:PNUC_RS03375
uniprot id: A4SWK1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

312153:PNUC RS02745
gene id: 312153:PNUC_RS02745
uniprot id: A4SW83
names: Similarity
messages: Belongs to the peptidase U62 family.

312153:PNUC RS10170
gene id: 312153:PNUC_RS10170
uniprot id: A4T0B1
names: Similarity
messages: Belongs to the UPF0250 family.

312153:PNUC RS00350
gene id: 312153:PNUC_RS00350
uniprot id: A4SUW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

312153:PNUC RS00605
gene id: 312153:PNUC_RS00605
uniprot id: A4SV18
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

312153:PNUC RS02670
gene id: 312153:PNUC_RS02670
uniprot id: A4SW68
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

312153:PNUC RS09185
gene id: 312153:PNUC_RS09185
uniprot id: A4SZR7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

312153:PNUC RS06505
gene id: 312153:PNUC_RS06505
uniprot id: A4SY90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

312153:PNUC RS07690
gene id: 312153:PNUC_RS07690
uniprot id: A4SYX0
names: Similarity
messages: Belongs to the RecJ family.

312153:PNUC RS03340
gene id: 312153:PNUC_RS03340
uniprot id: A4SWJ4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CoA-transferase III family. Frc subfamily.
messages: Homodimer.
messages: Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS00500
gene id: 312153:PNUC_RS00500
uniprot id: A4SUZ7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

312153:PNUC RS00790
gene id: 312153:PNUC_RS00790
uniprot id: A4SV52
names: Similarity
messages: Belongs to the TrpC family.

312153:PNUC RS09925
gene id: 312153:PNUC_RS09925
uniprot id: A4T063
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

312153:PNUC RS02585
gene id: 312153:PNUC_RS02585
uniprot id: A4SW51
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

312153:PNUC RS04930
gene id: 312153:PNUC_RS04930
uniprot id: A4SXE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

312153:PNUC RS10035
gene id: 312153:PNUC_RS10035
uniprot id: A4T084
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

312153:PNUC RS04005
gene id: 312153:PNUC_RS04005
uniprot id: A4SWX2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS00950
gene id: 312153:PNUC_RS00950
uniprot id: A4SV83
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: May bind 1 zinc ion per subunit.
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

312153:PNUC RS08390
gene id: 312153:PNUC_RS08390
uniprot id: A4SZB1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

312153:PNUC RS00420
gene id: 312153:PNUC_RS00420
uniprot id: A4SUY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

312153:PNUC RS05420
gene id: 312153:PNUC_RS05420
uniprot id: A4SXP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

312153:PNUC RS00795
gene id: 312153:PNUC_RS00795
uniprot id: A4SV53
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

312153:PNUC RS10070
gene id: 312153:PNUC_RS10070
uniprot id: A4T091
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

312153:PNUC RS00335
gene id: 312153:PNUC_RS00335
uniprot id: A4SUW5
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

312153:PNUC RS03410
gene id: 312153:PNUC_RS03410
uniprot id: A4SWK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

312153:PNUC RS02790
gene id: 312153:PNUC_RS02790
uniprot id: A4SW91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

312153:PNUC RS10015
gene id: 312153:PNUC_RS10015
uniprot id: A4T080
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS02730
gene id: 312153:PNUC_RS02730
uniprot id: A4SW80
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

312153:PNUC RS07205
gene id: 312153:PNUC_RS07205
uniprot id: A4SYM5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

312153:PNUC RS00775
gene id: 312153:PNUC_RS00775
uniprot id: A4SV49
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

312153:PNUC RS03005
gene id: 312153:PNUC_RS03005
uniprot id: A4SWD0
names: Similarity
messages: Belongs to the peptidase C59 family.

312153:PNUC RS04325
gene id: 312153:PNUC_RS04325
uniprot id: A4SX35
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

312153:PNUC RS01540
gene id: 312153:PNUC_RS01540
uniprot id: A4SVK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

312153:PNUC RS10760
gene id: 312153:PNUC_RS10760
uniprot id: A4T0M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

312153:PNUC RS02695
gene id: 312153:PNUC_RS02695
uniprot id: A4SW73
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

312153:PNUC RS05750
gene id: 312153:PNUC_RS05750
uniprot id: A4SXV2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

312153:PNUC RS00280
gene id: 312153:PNUC_RS00280
uniprot id: A4SUV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

312153:PNUC RS02115
gene id: 312153:PNUC_RS02115
uniprot id: A4SVW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

312153:PNUC RS02065
gene id: 312153:PNUC_RS02065
uniprot id: A4SVV0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YceF subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

312153:PNUC RS05680
gene id: 312153:PNUC_RS05680
uniprot id: A4SXU0
names: Similarity
messages: Belongs to the TPP enzyme family.

312153:PNUC RS00250
gene id: 312153:PNUC_RS00250
uniprot id: A4SUU8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS03250
gene id: 312153:PNUC_RS03250
uniprot id: A4SWH6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

312153:PNUC RS09990
gene id: 312153:PNUC_RS09990
uniprot id: A4T075
names: Similarity
messages: Belongs to the peptidase M16 family.

312153:PNUC RS06770
gene id: 312153:PNUC_RS06770
uniprot id: A4SYE1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

312153:PNUC RS08045
gene id: 312153:PNUC_RS08045
uniprot id: A4SZ41
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

312153:PNUC RS08015
gene id: 312153:PNUC_RS08015
uniprot id: A4SZ35
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

312153:PNUC RS03430
gene id: 312153:PNUC_RS03430
uniprot id: A4SWL2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiC family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.

312153:PNUC RS01485
gene id: 312153:PNUC_RS01485
uniprot id: A4SVI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

312153:PNUC RS02245
gene id: 312153:PNUC_RS02245
uniprot id: A4SVY4
names: Similarity
messages: Belongs to the PhoH family.

312153:PNUC RS04810
gene id: 312153:PNUC_RS04810
uniprot id: A4SXC6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

312153:PNUC RS03465
gene id: 312153:PNUC_RS03465
uniprot id: A4SWL9
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS00835
gene id: 312153:PNUC_RS00835
uniprot id: A4SV60
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS06475
gene id: 312153:PNUC_RS06475
uniprot id: A4SY84
names: Similarity
messages: Belongs to the peptidase C40 family.

312153:PNUC RS03115
gene id: 312153:PNUC_RS03115
uniprot id: A4SWF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

312153:PNUC RS07510
gene id: 312153:PNUC_RS07510
uniprot id: A4SYT5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

312153:PNUC RS10780
gene id: 312153:PNUC_RS10780
uniprot id: A4T0M8
names: Similarity
messages: Belongs to the type IA topoisomerase family.

312153:PNUC RS04470
gene id: 312153:PNUC_RS04470
uniprot id: A4SX64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

312153:PNUC RS02590
gene id: 312153:PNUC_RS02590
uniprot id: A4SW52
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

312153:PNUC RS00285
gene id: 312153:PNUC_RS00285
uniprot id: A4SUV5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

312153:PNUC RS02280
gene id: 312153:PNUC_RS02280
uniprot id: A4SVZ0
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

312153:PNUC RS05835
gene id: 312153:PNUC_RS05835
uniprot id: A4SXW7
names: Similarity
messages: Belongs to the YciI family.

312153:PNUC RS04900
gene id: 312153:PNUC_RS04900
uniprot id: A4SXE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

312153:PNUC RS07730
gene id: 312153:PNUC_RS07730
uniprot id: A4SYX8
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS06500
gene id: 312153:PNUC_RS06500
uniprot id: A4SY89
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

312153:PNUC RS07700
gene id: 312153:PNUC_RS07700
uniprot id: A4SYX2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

312153:PNUC RS06070
gene id: 312153:PNUC_RS06070
uniprot id: A4SY06
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SoxA family.
messages: Binds 2 heme groups per subunit.
messages: Heterodimer of SoxA and SoxX.
messages: Periplasm

312153:PNUC RS03550
gene id: 312153:PNUC_RS03550
uniprot id: A4SWN4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

312153:PNUC RS07415
gene id: 312153:PNUC_RS07415
uniprot id: A4SYR6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

312153:PNUC RS00005
gene id: 312153:PNUC_RS00005
uniprot id: A4SUQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

312153:PNUC RS05575
gene id: 312153:PNUC_RS05575
uniprot id: A4SXS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

312153:PNUC RS05155
gene id: 312153:PNUC_RS05155
uniprot id: A4SXI9
names: Similarity
messages: Belongs to the ABC transporter superfamily.

312153:PNUC RS01760
gene id: 312153:PNUC_RS01760
uniprot id: A4SVP2
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS09230
gene id: 312153:PNUC_RS09230
uniprot id: A4SZS6
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

312153:PNUC RS10520
gene id: 312153:PNUC_RS10520
uniprot id: A4T0I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate across the membrane.

312153:PNUC RS06510
gene id: 312153:PNUC_RS06510
uniprot id: A4SY91
names: Function
names: Similarity
messages: Belongs to the transposase IS30 family.
messages: Required for the transposition of the insertion element.

312153:PNUC RS02710
gene id: 312153:PNUC_RS02710
uniprot id: A4SW76
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

312153:PNUC RS02720
gene id: 312153:PNUC_RS02720
uniprot id: A4SW78
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

312153:PNUC RS09085
gene id: 312153:PNUC_RS09085
uniprot id: A4SZP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.

312153:PNUC RS08675
gene id: 312153:PNUC_RS08675
uniprot id: A4SZG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell inner membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

312153:PNUC RS08110
gene id: 312153:PNUC_RS08110
uniprot id: A4SZ54
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

312153:PNUC RS02335
gene id: 312153:PNUC_RS02335
uniprot id: A4SW01
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

312153:PNUC RS04430
gene id: 312153:PNUC_RS04430
uniprot id: A4SX56
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

312153:PNUC RS09500
gene id: 312153:PNUC_RS09500
uniprot id: A4SZY0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

312153:PNUC RS09760
gene id: 312153:PNUC_RS09760
uniprot id: A4T030
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

312153:PNUC RS09770
gene id: 312153:PNUC_RS09770
uniprot id: A4T032
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

312153:PNUC RS00175
gene id: 312153:PNUC_RS00175
uniprot id: A4SUU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

312153:PNUC RS04865
gene id: 312153:PNUC_RS04865
uniprot id: A4SXD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

312153:PNUC RS06010
gene id: 312153:PNUC_RS06010
uniprot id: A4SXZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

312153:PNUC RS09310
gene id: 312153:PNUC_RS09310
uniprot id: A4SZU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell inner membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

312153:PNUC RS00900
gene id: 312153:PNUC_RS00900
uniprot id: A4SV73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. FtsW subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell division.

312153:PNUC RS07540
gene id: 312153:PNUC_RS07540
uniprot id: A4SYU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

312153:PNUC RS05475
gene id: 312153:PNUC_RS05475
uniprot id: A4SXQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

312153:PNUC RS03060
gene id: 312153:PNUC_RS03060
uniprot id: A4SWE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

312153:PNUC RS01395
gene id: 312153:PNUC_RS01395
uniprot id: A4SVH1
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

312153:PNUC RS08900
gene id: 312153:PNUC_RS08900
uniprot id: A4SZL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

312153:PNUC RS10510
gene id: 312153:PNUC_RS10510
uniprot id: A4T0H9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

312153:PNUC RS00890
gene id: 312153:PNUC_RS00890
uniprot id: A4SV71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane

312153:PNUC RS02215
gene id: 312153:PNUC_RS02215
uniprot id: A4SVX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

312153:PNUC RS02865
gene id: 312153:PNUC_RS02865
uniprot id: A4SWA6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

312153:PNUC RS04085
gene id: 312153:PNUC_RS04085
uniprot id: A4SWY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

312153:PNUC RS05645
gene id: 312153:PNUC_RS05645
uniprot id: A4SXT3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

312153:PNUC RS02175
gene id: 312153:PNUC_RS02175
uniprot id: A4SVX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

312153:PNUC RS02040
gene id: 312153:PNUC_RS02040
uniprot id: A4SVU5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase E/G family. RNase E subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per homotetramer.
messages: Cell inner membrane
messages: Cytoplasm
messages: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.
messages: Homotetramer formed by a dimer of dimers.

312153:PNUC RS00385
gene id: 312153:PNUC_RS00385
uniprot id: A4SUX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

312153:PNUC RS04950
gene id: 312153:PNUC_RS04950
uniprot id: A4SXF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

312153:PNUC RS10250
gene id: 312153:PNUC_RS10250
uniprot id: A4T0C7
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

312153:PNUC RS03270
gene id: 312153:PNUC_RS03270
uniprot id: A4SWI0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

312153:PNUC RS09930
gene id: 312153:PNUC_RS09930
uniprot id: A4T064
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

312153:PNUC RS00575
gene id: 312153:PNUC_RS00575
uniprot id: A4SV12
names: Similarity
messages: Belongs to the BolA/IbaG family.

312153:PNUC RS08660
gene id: 312153:PNUC_RS08660
uniprot id: A4SZG4
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS04055
gene id: 312153:PNUC_RS04055
uniprot id: A4SWY2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS05450
gene id: 312153:PNUC_RS05450
uniprot id: A4SXP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

312153:PNUC RS09670
gene id: 312153:PNUC_RS09670
uniprot id: A4T012
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

312153:PNUC RS04315
gene id: 312153:PNUC_RS04315
uniprot id: A4SX33
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

312153:PNUC RS02145
gene id: 312153:PNUC_RS02145
uniprot id: A4SVW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

312153:PNUC RS09765
gene id: 312153:PNUC_RS09765
uniprot id: A4T031
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters.

312153:PNUC RS08255
gene id: 312153:PNUC_RS08255
uniprot id: A4SZ83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

312153:PNUC RS03820
gene id: 312153:PNUC_RS03820
uniprot id: A4SWT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

312153:PNUC RS00410
gene id: 312153:PNUC_RS00410
uniprot id: A4SUY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

312153:PNUC RS09335
gene id: 312153:PNUC_RS09335
uniprot id: A4SZU7
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

312153:PNUC RS00075
gene id: 312153:PNUC_RS00075
uniprot id: A4SUS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

312153:PNUC RS05805
gene id: 312153:PNUC_RS05805
uniprot id: A4SXW2
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

312153:PNUC RS01995
gene id: 312153:PNUC_RS01995
uniprot id: A4SVT6
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

312153:PNUC RS00765
gene id: 312153:PNUC_RS00765
uniprot id: A4SV47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.

312153:PNUC RS01165
gene id: 312153:PNUC_RS01165
uniprot id: A4SVC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 51 family.
messages: Cell inner membrane
messages: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.

312153:PNUC RS00715
gene id: 312153:PNUC_RS00715
uniprot id: A4SV38
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS10195
gene id: 312153:PNUC_RS10195
uniprot id: A4T0B6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS06585
gene id: 312153:PNUC_RS06585
uniprot id: A4SYA5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

312153:PNUC RS06270
gene id: 312153:PNUC_RS06270
uniprot id: A4SY44
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

312153:PNUC RS01005
gene id: 312153:PNUC_RS01005
uniprot id: A4SV94
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS05535
gene id: 312153:PNUC_RS05535
uniprot id: A4SXR2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

312153:PNUC RS09420
gene id: 312153:PNUC_RS09420
uniprot id: A4SZW4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

312153:PNUC RS04155
gene id: 312153:PNUC_RS04155
uniprot id: A4SX02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

312153:PNUC RS00595
gene id: 312153:PNUC_RS00595
uniprot id: A4SV16
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

312153:PNUC RS05425
gene id: 312153:PNUC_RS05425
uniprot id: A4SXP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

312153:PNUC RS08735
gene id: 312153:PNUC_RS08735
uniprot id: A4SZH8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

312153:PNUC RS06430
gene id: 312153:PNUC_RS06430
uniprot id: A4SY75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

312153:PNUC RS07140
gene id: 312153:PNUC_RS07140
uniprot id: A4SYL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.

312153:PNUC RS03435
gene id: 312153:PNUC_RS03435
uniprot id: A4SWL3
names: Similarity
messages: Belongs to the DEAD box helicase family.

312153:PNUC RS03770
gene id: 312153:PNUC_RS03770
uniprot id: A4SWS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

312153:PNUC RS02035
gene id: 312153:PNUC_RS02035
uniprot id: A4SVU4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

312153:PNUC RS05165
gene id: 312153:PNUC_RS05165
uniprot id: A4SXJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

312153:PNUC RS06545
gene id: 312153:PNUC_RS06545
uniprot id: A4SY98
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS01195
gene id: 312153:PNUC_RS01195
uniprot id: A4SVD1
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

312153:PNUC RS09260
gene id: 312153:PNUC_RS09260
uniprot id: A4SZT2
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

312153:PNUC RS04400
gene id: 312153:PNUC_RS04400
uniprot id: A4SX49
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS03155
gene id: 312153:PNUC_RS03155
uniprot id: A4SWF8
names: Similarity
messages: Belongs to the DEAD box helicase family.

312153:PNUC RS10495
gene id: 312153:PNUC_RS10495
uniprot id: A4T0H6
names: Similarity
messages: Belongs to the UPF0235 family.

312153:PNUC RS06735
gene id: 312153:PNUC_RS06735
uniprot id: A4SYD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

312153:PNUC RS00615
gene id: 312153:PNUC_RS00615
uniprot id: A4SV20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

312153:PNUC RS10440
gene id: 312153:PNUC_RS10440
uniprot id: A4T0G5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

312153:PNUC RS02075
gene id: 312153:PNUC_RS02075
uniprot id: A4SVV2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

312153:PNUC RS01050
gene id: 312153:PNUC_RS01050
uniprot id: A4SVA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

312153:PNUC RS02320
gene id: 312153:PNUC_RS02320
uniprot id: A4SVZ8
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

312153:PNUC RS10460
gene id: 312153:PNUC_RS10460
uniprot id: A4T0G9
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

312153:PNUC RS04435
gene id: 312153:PNUC_RS04435
uniprot id: A4SX57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

312153:PNUC RS09755
gene id: 312153:PNUC_RS09755
uniprot id: A4T029
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

312153:PNUC RS03565
gene id: 312153:PNUC_RS03565
uniprot id: A4SWN7
names: Similarity
messages: Belongs to the P(II) protein family.

312153:PNUC RS01185
gene id: 312153:PNUC_RS01185
uniprot id: A4SVC9
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

312153:PNUC RS09975
gene id: 312153:PNUC_RS09975
uniprot id: A4T072
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

312153:PNUC RS09275
gene id: 312153:PNUC_RS09275
uniprot id: A4SZT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
messages: Cell inner membrane

312153:PNUC RS01065
gene id: 312153:PNUC_RS01065
uniprot id: A4SVA6
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

312153:PNUC RS10455
gene id: 312153:PNUC_RS10455
uniprot id: A4T0G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

312153:PNUC RS05340
gene id: 312153:PNUC_RS05340
uniprot id: A4SXM4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Monomer.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

312153:PNUC RS08400
gene id: 312153:PNUC_RS08400
uniprot id: A4SZB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

312153:PNUC RS03675
gene id: 312153:PNUC_RS03675
uniprot id: A4SWQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OprB family.
messages: Cell outer membrane

312153:PNUC RS10055
gene id: 312153:PNUC_RS10055
uniprot id: A4T088
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Cell membrane
messages: Membrane
messages: Periplasm
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

312153:PNUC RS07350
gene id: 312153:PNUC_RS07350
uniprot id: A4SYQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

312153:PNUC RS00290
gene id: 312153:PNUC_RS00290
uniprot id: A4SUV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

312153:PNUC RS09040
gene id: 312153:PNUC_RS09040
uniprot id: A4SZN8
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

312153:PNUC RS08345
gene id: 312153:PNUC_RS08345
uniprot id: A4SZA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

312153:PNUC RS03480
gene id: 312153:PNUC_RS03480
uniprot id: A4SWM2
names: Similarity
messages: Belongs to the peptidase M1 family.

312153:PNUC RS10000
gene id: 312153:PNUC_RS10000
uniprot id: A4T077
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

312153:PNUC RS04340
gene id: 312153:PNUC_RS04340
uniprot id: A4SX38
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

312153:PNUC RS01255
gene id: 312153:PNUC_RS01255
uniprot id: A4SVE3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

312153:PNUC RS01795
gene id: 312153:PNUC_RS01795
uniprot id: A4SVP9
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

312153:PNUC RS05050
gene id: 312153:PNUC_RS05050
uniprot id: A4SXG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell inner membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

312153:PNUC RS01280
gene id: 312153:PNUC_RS01280
uniprot id: A4SVE8
names: Similarity
messages: Belongs to the DNA photolyase family.

312153:PNUC RS09395
gene id: 312153:PNUC_RS09395
uniprot id: A4SZV9
names: Similarity
messages: Belongs to the peptidase S13 family.

312153:PNUC RS04140
gene id: 312153:PNUC_RS04140
uniprot id: A4SWZ9
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS04825
gene id: 312153:PNUC_RS04825
uniprot id: A4SXC9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

312153:PNUC RS09195
gene id: 312153:PNUC_RS09195
uniprot id: A4SZR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

312153:PNUC RS00940
gene id: 312153:PNUC_RS00940
uniprot id: A4SV81
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

312153:PNUC RS05500
gene id: 312153:PNUC_RS05500
uniprot id: A4SXQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

312153:PNUC RS03240
gene id: 312153:PNUC_RS03240
uniprot id: A4SWH4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

312153:PNUC RS05530
gene id: 312153:PNUC_RS05530
uniprot id: A4SXR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

312153:PNUC RS00320
gene id: 312153:PNUC_RS00320
uniprot id: A4SUW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

312153:PNUC RS07870
gene id: 312153:PNUC_RS07870
uniprot id: A4SZ06
names: Cofactor
messages: Can also use Mn(2+) ion.

312153:PNUC RS00295
gene id: 312153:PNUC_RS00295
uniprot id: A4SUV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

312153:PNUC RS10150
gene id: 312153:PNUC_RS10150
uniprot id: A4T0A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.

312153:PNUC RS01510
gene id: 312153:PNUC_RS01510
uniprot id: A4SVJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

312153:PNUC RS09800
gene id: 312153:PNUC_RS09800
uniprot id: A4T038
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS01330
gene id: 312153:PNUC_RS01330
uniprot id: A4SVF8
names: Similarity
messages: Belongs to the glycosyltransferase 10 family.

312153:PNUC RS09205
gene id: 312153:PNUC_RS09205
uniprot id: A4SZS1
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

312153:PNUC RS09505
gene id: 312153:PNUC_RS09505
uniprot id: A4SZY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

312153:PNUC RS10240
gene id: 312153:PNUC_RS10240
uniprot id: A4T0C5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

312153:PNUC RS09875
gene id: 312153:PNUC_RS09875
uniprot id: A4T053
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

312153:PNUC RS05780
gene id: 312153:PNUC_RS05780
uniprot id: A4SXV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

312153:PNUC RS04845
gene id: 312153:PNUC_RS04845
uniprot id: A4SXD3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS05705
gene id: 312153:PNUC_RS05705
uniprot id: A4SXU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

312153:PNUC RS01660
gene id: 312153:PNUC_RS01660
uniprot id: A4SVM3
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS01175
gene id: 312153:PNUC_RS01175
uniprot id: A4SVC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

312153:PNUC RS02520
gene id: 312153:PNUC_RS02520
uniprot id: A4SW38
names: Similarity
messages: Belongs to the PrpD family.

312153:PNUC RS06310
gene id: 312153:PNUC_RS06310
uniprot id: A4SY52
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS07605
gene id: 312153:PNUC_RS07605
uniprot id: A4SYV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

312153:PNUC RS09210
gene id: 312153:PNUC_RS09210
uniprot id: A4SZS2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS03490
gene id: 312153:PNUC_RS03490
uniprot id: A4SWM4
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).
messages: Homodimer.
messages: In the C-terminal section; belongs to the MurCDEF family.

312153:PNUC RS07280
gene id: 312153:PNUC_RS07280
uniprot id: A4SYP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell inner membrane

312153:PNUC RS01270
gene id: 312153:PNUC_RS01270
uniprot id: A4SVE6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

312153:PNUC RS06935
gene id: 312153:PNUC_RS06935
uniprot id: A4SYH2
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS02995
gene id: 312153:PNUC_RS02995
uniprot id: A4SWC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

312153:PNUC RS01070
gene id: 312153:PNUC_RS01070
uniprot id: A4SVA7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

312153:PNUC RS01495
gene id: 312153:PNUC_RS01495
uniprot id: A4SVJ1
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

312153:PNUC RS01505
gene id: 312153:PNUC_RS01505
uniprot id: A4SVJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

312153:PNUC RS06570
gene id: 312153:PNUC_RS06570
uniprot id: A4SYA2
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

312153:PNUC RS00115
gene id: 312153:PNUC_RS00115
uniprot id: A4SUT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

312153:PNUC RS00865
gene id: 312153:PNUC_RS00865
uniprot id: A4SV66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

312153:PNUC RS03590
gene id: 312153:PNUC_RS03590
uniprot id: A4SWP2
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

312153:PNUC RS01365
gene id: 312153:PNUC_RS01365
uniprot id: A4SVG5
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

312153:PNUC RS06750
gene id: 312153:PNUC_RS06750
uniprot id: A4SYD7
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

312153:PNUC RS03580
gene id: 312153:PNUC_RS03580
uniprot id: A4SWP0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell inner membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

312153:PNUC RS00600
gene id: 312153:PNUC_RS00600
uniprot id: A4SV17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

312153:PNUC RS06320
gene id: 312153:PNUC_RS06320
uniprot id: A4SY54
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

312153:PNUC RS07370
gene id: 312153:PNUC_RS07370
uniprot id: A4SYQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

312153:PNUC RS02080
gene id: 312153:PNUC_RS02080
uniprot id: A4SVV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

312153:PNUC RS04870
gene id: 312153:PNUC_RS04870
uniprot id: A4SXD7
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

312153:PNUC RS09300
gene id: 312153:PNUC_RS09300
uniprot id: A4SZU0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

312153:PNUC RS06785
gene id: 312153:PNUC_RS06785
uniprot id: A4SYE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

312153:PNUC RS09240
gene id: 312153:PNUC_RS09240
uniprot id: A4SZS8
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

312153:PNUC RS02310
gene id: 312153:PNUC_RS02310
uniprot id: A4SVZ6
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

312153:PNUC RS01040
gene id: 312153:PNUC_RS01040
uniprot id: A4SVA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

312153:PNUC RS02580
gene id: 312153:PNUC_RS02580
uniprot id: A4SW50
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS07640
gene id: 312153:PNUC_RS07640
uniprot id: A4SYW1
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

312153:PNUC RS09270
gene id: 312153:PNUC_RS09270
uniprot id: A4SZT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

312153:PNUC RS00540
gene id: 312153:PNUC_RS00540
uniprot id: A4SV05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane

312153:PNUC RS01855
gene id: 312153:PNUC_RS01855
uniprot id: A4SVQ9
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

312153:PNUC RS01200
gene id: 312153:PNUC_RS01200
uniprot id: A4SVD2
names: Similarity
messages: Belongs to the barstar family.

312153:PNUC RS09610
gene id: 312153:PNUC_RS09610
uniprot id: A4T000
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

312153:PNUC RS08510
gene id: 312153:PNUC_RS08510
uniprot id: A4SZD5
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS00855
gene id: 312153:PNUC_RS00855
uniprot id: A4SV64
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
messages: Cell membrane

312153:PNUC RS02160
gene id: 312153:PNUC_RS02160
uniprot id: A4SVW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

312153:PNUC RS10425
gene id: 312153:PNUC_RS10425
uniprot id: A4T0G2
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

312153:PNUC RS01220
gene id: 312153:PNUC_RS01220
uniprot id: A4SVD6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

312153:PNUC RS09740
gene id: 312153:PNUC_RS09740
uniprot id: A4T026
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

312153:PNUC RS07985
gene id: 312153:PNUC_RS07985
uniprot id: A4SZ29
names: Similarity
messages: Belongs to the histone deacetylase family.

312153:PNUC RS02615
gene id: 312153:PNUC_RS02615
uniprot id: A4SW57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

312153:PNUC RS02000
gene id: 312153:PNUC_RS02000
uniprot id: A4SVT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

312153:PNUC RS07565
gene id: 312153:PNUC_RS07565
uniprot id: A4SYU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

312153:PNUC RS03660
gene id: 312153:PNUC_RS03660
uniprot id: A4SWQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

312153:PNUC RS09885
gene id: 312153:PNUC_RS09885
uniprot id: A4T055
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

312153:PNUC RS02705
gene id: 312153:PNUC_RS02705
uniprot id: A4SW75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

312153:PNUC RS01425
gene id: 312153:PNUC_RS01425
uniprot id: A4SVH7
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

312153:PNUC RS00120
gene id: 312153:PNUC_RS00120
uniprot id: A4SUT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

312153:PNUC RS00360
gene id: 312153:PNUC_RS00360
uniprot id: A4SUX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

312153:PNUC RS09340
gene id: 312153:PNUC_RS09340
uniprot id: A4SZU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

312153:PNUC RS02120
gene id: 312153:PNUC_RS02120
uniprot id: A4SVW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

312153:PNUC RS03425
gene id: 312153:PNUC_RS03425
uniprot id: A4SWL1
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

312153:PNUC RS05430
gene id: 312153:PNUC_RS05430
uniprot id: A4SXP2
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS01915
gene id: 312153:PNUC_RS01915
uniprot id: A4SVS1
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

312153:PNUC RS05550
gene id: 312153:PNUC_RS05550
uniprot id: A4SXR5
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

312153:PNUC RS09220
gene id: 312153:PNUC_RS09220
uniprot id: A4SZS4
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

312153:PNUC RS06805
gene id: 312153:PNUC_RS06805
uniprot id: A4SYE8
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

312153:PNUC RS00805
gene id: 312153:PNUC_RS00805
uniprot id: A4SV55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

312153:PNUC RS10790
gene id: 312153:PNUC_RS10790
uniprot id: A4T0N1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

312153:PNUC RS04790
gene id: 312153:PNUC_RS04790
uniprot id: A4SXC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamD family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

312153:PNUC RS04445
gene id: 312153:PNUC_RS04445
uniprot id: A4SX59
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxH family.
messages: Binds 2 Mn(2+) ions per subunit in a binuclear metal center.
messages: Cell inner membrane
messages: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS05460
gene id: 312153:PNUC_RS05460
uniprot id: A4SXP8
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

312153:PNUC RS09430
gene id: 312153:PNUC_RS09430
uniprot id: A4SZW6
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

312153:PNUC RS04255
gene id: 312153:PNUC_RS04255
uniprot id: A4SX22
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

312153:PNUC RS02680
gene id: 312153:PNUC_RS02680
uniprot id: A4SW70
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

312153:PNUC RS10795
gene id: 312153:PNUC_RS10795
uniprot id: A4T0N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

312153:PNUC RS05085
gene id: 312153:PNUC_RS05085
uniprot id: A4SXH6
names: Similarity
messages: Belongs to the BolA/IbaG family.

312153:PNUC RS03185
gene id: 312153:PNUC_RS03185
uniprot id: A4SWG4
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS03360
gene id: 312153:PNUC_RS03360
uniprot id: A4SWJ8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

312153:PNUC RS08010
gene id: 312153:PNUC_RS08010
uniprot id: A4SZ34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

312153:PNUC RS00625
gene id: 312153:PNUC_RS00625
uniprot id: A4SV22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

312153:PNUC RS03415
gene id: 312153:PNUC_RS03415
uniprot id: A4SWK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

312153:PNUC RS08910
gene id: 312153:PNUC_RS08910
uniprot id: A4SZL2
names: Similarity
messages: Belongs to the pseudomonas-type ThrB family.

312153:PNUC RS00130
gene id: 312153:PNUC_RS00130
uniprot id: A4SUT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

312153:PNUC RS00045
gene id: 312153:PNUC_RS00045
uniprot id: A4SUR7
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS02495
gene id: 312153:PNUC_RS02495
uniprot id: A4SW33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

312153:PNUC RS05095
gene id: 312153:PNUC_RS05095
uniprot id: A4SXH8
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS03400
gene id: 312153:PNUC_RS03400
uniprot id: A4SWK6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

312153:PNUC RS04450
gene id: 312153:PNUC_RS04450
uniprot id: A4SX60
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

312153:PNUC RS10445
gene id: 312153:PNUC_RS10445
uniprot id: A4T0G6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

312153:PNUC RS00935
gene id: 312153:PNUC_RS00935
uniprot id: A4SV80
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

312153:PNUC RS09935
gene id: 312153:PNUC_RS09935
uniprot id: A4T065
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

312153:PNUC RS10315
gene id: 312153:PNUC_RS10315
uniprot id: A4T0E0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.
messages: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
messages: Cytoplasm
messages: Homodimer.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

312153:PNUC RS06065
gene id: 312153:PNUC_RS06065
uniprot id: A4SY05
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

312153:PNUC RS05525
gene id: 312153:PNUC_RS05525
uniprot id: A4SXR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

312153:PNUC RS03755
gene id: 312153:PNUC_RS03755
uniprot id: A4SWS2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
messages: Monomer.

312153:PNUC RS07165
gene id: 312153:PNUC_RS07165
uniprot id: A4SYL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

312153:PNUC RS02165
gene id: 312153:PNUC_RS02165
uniprot id: A4SVX0
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 104 family.
messages: Protein-arginine rhamnosyltransferase that catalyzes the transfer of a single rhamnose to elongation factor P (EF-P) on 'Lys-32', a modification required for EF-P-dependent rescue of polyproline stalled ribosomes.

312153:PNUC RS06825
gene id: 312153:PNUC_RS06825
uniprot id: A4SYF2
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

312153:PNUC RS02890
gene id: 312153:PNUC_RS02890
uniprot id: A4SWB1
names: Cofactor
messages: Binds 3 heme c groups covalently per subunit.

312153:PNUC RS00880
gene id: 312153:PNUC_RS00880
uniprot id: A4SV69
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS02895
gene id: 312153:PNUC_RS02895
uniprot id: A4SWB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

312153:PNUC RS02225
gene id: 312153:PNUC_RS02225
uniprot id: A4SVY0
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

312153:PNUC RS09955
gene id: 312153:PNUC_RS09955
uniprot id: A4T068
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

312153:PNUC RS03975
gene id: 312153:PNUC_RS03975
uniprot id: A4SWW6
names: Similarity
messages: Belongs to the SdhE FAD assembly factor family.

312153:PNUC RS03445
gene id: 312153:PNUC_RS03445
uniprot id: A4SWL5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

312153:PNUC RS01470
gene id: 312153:PNUC_RS01470
uniprot id: A4SVI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

312153:PNUC RS04225
gene id: 312153:PNUC_RS04225
uniprot id: A4SX16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

312153:PNUC RS08430
gene id: 312153:PNUC_RS08430
uniprot id: A4SZB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cdh family.
messages: Membrane

312153:PNUC RS09890
gene id: 312153:PNUC_RS09890
uniprot id: A4T056
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

312153:PNUC RS02480
gene id: 312153:PNUC_RS02480
uniprot id: A4SW30
names: PTM
messages: Binds 1 heme group per subunit.

312153:PNUC RS01350
gene id: 312153:PNUC_RS01350
uniprot id: A4SVG2
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

312153:PNUC RS06660
gene id: 312153:PNUC_RS06660
uniprot id: A4SYC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

312153:PNUC RS06740
gene id: 312153:PNUC_RS06740
uniprot id: A4SYD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

312153:PNUC RS04645
gene id: 312153:PNUC_RS04645
uniprot id: A4SX94
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS03530
gene id: 312153:PNUC_RS03530
uniprot id: A4SWN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

312153:PNUC RS00255
gene id: 312153:PNUC_RS00255
uniprot id: A4SUU9
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

312153:PNUC RS08850
gene id: 312153:PNUC_RS08850
uniprot id: A4SZK0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

312153:PNUC RS09480
gene id: 312153:PNUC_RS09480
uniprot id: A4SZX6
names: Similarity
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.

312153:PNUC RS00585
gene id: 312153:PNUC_RS00585
uniprot id: A4SV14
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

312153:PNUC RS00440
gene id: 312153:PNUC_RS00440
uniprot id: A4SUY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

312153:PNUC RS03880
gene id: 312153:PNUC_RS03880
uniprot id: A4SWU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

312153:PNUC RS05045
gene id: 312153:PNUC_RS05045
uniprot id: A4SXG8
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

312153:PNUC RS07725
gene id: 312153:PNUC_RS07725
uniprot id: A4SYX7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

312153:PNUC RS07460
gene id: 312153:PNUC_RS07460
uniprot id: A4SYS5
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

312153:PNUC RS04770
gene id: 312153:PNUC_RS04770
uniprot id: A4SXB8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein S18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS10330
gene id: 312153:PNUC_RS10330
uniprot id: A4T0E3
names: Subcellular Location Annotation
messages: Mitochondrion

312153:PNUC RS01970
gene id: 312153:PNUC_RS01970
uniprot id: A4SVT2
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

312153:PNUC RS06810
gene id: 312153:PNUC_RS06810
uniprot id: A4SYE9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

312153:PNUC RS07740
gene id: 312153:PNUC_RS07740
uniprot id: A4SYY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

312153:PNUC RS06265
gene id: 312153:PNUC_RS06265
uniprot id: A4SY43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

312153:PNUC RS02635
gene id: 312153:PNUC_RS02635
uniprot id: A4SW61
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

312153:PNUC RS08165
gene id: 312153:PNUC_RS08165
uniprot id: A4SZ65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.

312153:PNUC RS02010
gene id: 312153:PNUC_RS02010
uniprot id: A4SVT9
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

312153:PNUC RS05470
gene id: 312153:PNUC_RS05470
uniprot id: A4SXQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

312153:PNUC RS02235
gene id: 312153:PNUC_RS02235
uniprot id: A4SVY2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
messages: Membrane

312153:PNUC RS06260
gene id: 312153:PNUC_RS06260
uniprot id: A4SY42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreF family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

312153:PNUC RS10310
gene id: 312153:PNUC_RS10310
uniprot id: A4T0D9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

312153:PNUC RS03690
gene id: 312153:PNUC_RS03690
uniprot id: A4SWR0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrQ family.
messages: Binds 1 FMN per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Cell inner membrane
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.

312153:PNUC RS03045
gene id: 312153:PNUC_RS03045
uniprot id: A4SWD8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

312153:PNUC RS06975
gene id: 312153:PNUC_RS06975
uniprot id: A4SYI0
names: Similarity
messages: Belongs to the FeoA family.

312153:PNUC RS03355
gene id: 312153:PNUC_RS03355
uniprot id: A4SWJ7
names: Similarity
messages: Belongs to the peptidase C59 family.

312153:PNUC RS00415
gene id: 312153:PNUC_RS00415
uniprot id: A4SUY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

312153:PNUC RS09015
gene id: 312153:PNUC_RS09015
uniprot id: A4SZN3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

312153:PNUC RS04330
gene id: 312153:PNUC_RS04330
uniprot id: A4SX36
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

312153:PNUC RS08920
gene id: 312153:PNUC_RS08920
uniprot id: A4SZL4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

312153:PNUC RS09650
gene id: 312153:PNUC_RS09650
uniprot id: A4T008
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

312153:PNUC RS06105
gene id: 312153:PNUC_RS06105
uniprot id: A4SY13
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS05985
gene id: 312153:PNUC_RS05985
uniprot id: A4SXZ0
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS10140
gene id: 312153:PNUC_RS10140
uniprot id: A4T0A5
names: Similarity
messages: Belongs to the P(II) protein family.

312153:PNUC RS03475
gene id: 312153:PNUC_RS03475
uniprot id: A4SWM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

312153:PNUC RS02090
gene id: 312153:PNUC_RS02090
uniprot id: A4SVV5
names: Similarity
messages: Belongs to the fabD family.

312153:PNUC RS07615
gene id: 312153:PNUC_RS07615
uniprot id: A4SYV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZipA family.
messages: Cell inner membrane
messages: Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.

312153:PNUC RS01460
gene id: 312153:PNUC_RS01460
uniprot id: A4SVI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

312153:PNUC RS02285
gene id: 312153:PNUC_RS02285
uniprot id: A4SVZ1
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS05745
gene id: 312153:PNUC_RS05745
uniprot id: A4SXV1
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

312153:PNUC RS05070
gene id: 312153:PNUC_RS05070
uniprot id: A4SXH3
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

312153:PNUC RS04190
gene id: 312153:PNUC_RS04190
uniprot id: A4SX09
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SoxA family.
messages: Binds 2 heme groups per subunit.
messages: Heterodimer of SoxA and SoxX.
messages: Periplasm

312153:PNUC RS09135
gene id: 312153:PNUC_RS09135
uniprot id: A4SZQ7
names: Similarity
messages: Belongs to the UPF0162 family.

312153:PNUC RS02305
gene id: 312153:PNUC_RS02305
uniprot id: A4SVZ5
names: Similarity
messages: Belongs to the threonine synthase family.

312153:PNUC RS07235
gene id: 312153:PNUC_RS07235
uniprot id: A4SYN1
names: Similarity
messages: Belongs to the bacterial secretin family.

312153:PNUC RS02445
gene id: 312153:PNUC_RS02445
uniprot id: A4SW23
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

312153:PNUC RS03055
gene id: 312153:PNUC_RS03055
uniprot id: A4SWE0
names: Subcellular Location Annotation
messages: Cytoplasm

312153:PNUC RS02005
gene id: 312153:PNUC_RS02005
uniprot id: A4SVT8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

312153:PNUC RS03570
gene id: 312153:PNUC_RS03570
uniprot id: A4SWN8
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS02095
gene id: 312153:PNUC_RS02095
uniprot id: A4SVV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

312153:PNUC RS01130
gene id: 312153:PNUC_RS01130
uniprot id: A4SVB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

312153:PNUC RS01275
gene id: 312153:PNUC_RS01275
uniprot id: A4SVE7
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

312153:PNUC RS01295
gene id: 312153:PNUC_RS01295
uniprot id: A4SVF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

312153:PNUC RS10080
gene id: 312153:PNUC_RS10080
uniprot id: A4T093
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

312153:PNUC RS09810
gene id: 312153:PNUC_RS09810
uniprot id: A4T040
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

312153:PNUC RS09690
gene id: 312153:PNUC_RS09690
uniprot id: A4T016
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

312153:PNUC RS02625
gene id: 312153:PNUC_RS02625
uniprot id: A4SW59
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

312153:PNUC RS02330
gene id: 312153:PNUC_RS02330
uniprot id: A4SW00
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS08875
gene id: 312153:PNUC_RS08875
uniprot id: A4SZK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

312153:PNUC RS04285
gene id: 312153:PNUC_RS04285
uniprot id: A4SX28
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

312153:PNUC RS02565
gene id: 312153:PNUC_RS02565
uniprot id: A4SW47
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

312153:PNUC RS10205
gene id: 312153:PNUC_RS10205
uniprot id: A4T0B8
names: Similarity
messages: Belongs to the glutathione peroxidase family.

312153:PNUC RS09215
gene id: 312153:PNUC_RS09215
uniprot id: A4SZS3
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

312153:PNUC RS03200
gene id: 312153:PNUC_RS03200
uniprot id: A4SWG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

312153:PNUC RS01475
gene id: 312153:PNUC_RS01475
uniprot id: A4SVI7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

312153:PNUC RS05485
gene id: 312153:PNUC_RS05485
uniprot id: A4SXQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

312153:PNUC RS03610
gene id: 312153:PNUC_RS03610
uniprot id: A4SWP6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

312153:PNUC RS06470
gene id: 312153:PNUC_RS06470
uniprot id: A4SY83
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS00755
gene id: 312153:PNUC_RS00755
uniprot id: A4SV45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

312153:PNUC RS04060
gene id: 312153:PNUC_RS04060
uniprot id: A4SWY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MetZ subfamily.
messages: Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
messages: Homotetramer.

312153:PNUC RS04665
gene id: 312153:PNUC_RS04665
uniprot id: A4SX98
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

312153:PNUC RS05570
gene id: 312153:PNUC_RS05570
uniprot id: A4SXR9
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS07745
gene id: 312153:PNUC_RS07745
uniprot id: A4SYY1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

312153:PNUC RS07910
gene id: 312153:PNUC_RS07910
uniprot id: A4SZ14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

312153:PNUC RS08125
gene id: 312153:PNUC_RS08125
uniprot id: A4SZ57
names: Similarity
messages: Belongs to the HIBADH-related family.

312153:PNUC RS02500
gene id: 312153:PNUC_RS02500
uniprot id: A4SW34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

312153:PNUC RS01930
gene id: 312153:PNUC_RS01930
uniprot id: A4SVS4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrP family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

312153:PNUC RS00965
gene id: 312153:PNUC_RS00965
uniprot id: A4SV86
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

312153:PNUC RS10465
gene id: 312153:PNUC_RS10465
uniprot id: A4T0H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

312153:PNUC RS07320
gene id: 312153:PNUC_RS07320
uniprot id: A4SYP8
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

312153:PNUC RS09750
gene id: 312153:PNUC_RS09750
uniprot id: A4T028
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

312153:PNUC RS01525
gene id: 312153:PNUC_RS01525
uniprot id: A4SVJ7
names: Similarity
messages: Belongs to the UPF0234 family.

312153:PNUC RS00580
gene id: 312153:PNUC_RS00580
uniprot id: A4SV13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

312153:PNUC RS02030
gene id: 312153:PNUC_RS02030
uniprot id: A4SVU3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

312153:PNUC RS07630
gene id: 312153:PNUC_RS07630
uniprot id: A4SYV9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

312153:PNUC RS06165
gene id: 312153:PNUC_RS06165
uniprot id: A4SY25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

312153:PNUC RS09675
gene id: 312153:PNUC_RS09675
uniprot id: A4T013
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gmhB family.
messages: Cytoplasm
messages: Monomer.

312153:PNUC RS05200
gene id: 312153:PNUC_RS05200
uniprot id: A4SXJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

312153:PNUC RS06765
gene id: 312153:PNUC_RS06765
uniprot id: A4SYE0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

312153:PNUC RS10110
gene id: 312153:PNUC_RS10110
uniprot id: A4T099
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

312153:PNUC RS02325
gene id: 312153:PNUC_RS02325
uniprot id: A4SVZ9
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

312153:PNUC RS09410
gene id: 312153:PNUC_RS09410
uniprot id: A4SZW2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

312153:PNUC RS00340
gene id: 312153:PNUC_RS00340
uniprot id: A4SUW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

312153:PNUC RS08230
gene id: 312153:PNUC_RS08230
uniprot id: A4SZ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

312153:PNUC RS09295
gene id: 312153:PNUC_RS09295
uniprot id: A4SZT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

312153:PNUC RS04460
gene id: 312153:PNUC_RS04460
uniprot id: A4SX62
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

312153:PNUC RS00930
gene id: 312153:PNUC_RS00930
uniprot id: A4SV79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

312153:PNUC RS08680
gene id: 312153:PNUC_RS08680
uniprot id: A4SZG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell inner membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

312153:PNUC RS02425
gene id: 312153:PNUC_RS02425
uniprot id: A4SW19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

312153:PNUC RS03905
gene id: 312153:PNUC_RS03905
uniprot id: A4SWV2
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

312153:PNUC RS09145
gene id: 312153:PNUC_RS09145
uniprot id: A4SZQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Monomer.

312153:PNUC RS09025
gene id: 312153:PNUC_RS09025
uniprot id: A4SZN5
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS05110
gene id: 312153:PNUC_RS05110
uniprot id: A4SXI1
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS00920
gene id: 312153:PNUC_RS00920
uniprot id: A4SV77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsQ/DivIB family. FtsQ subfamily.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

312153:PNUC RS09660
gene id: 312153:PNUC_RS09660
uniprot id: A4T010
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

312153:PNUC RS06700
gene id: 312153:PNUC_RS06700
uniprot id: A4SYC7
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS03325
gene id: 312153:PNUC_RS03325
uniprot id: A4SWJ1
names: Similarity
messages: Belongs to the TPP enzyme family.

312153:PNUC RS07065
gene id: 312153:PNUC_RS07065
uniprot id: A4SYJ8
names: Function
messages: Might have a role analogous to that of eukaryotic histone proteins.

312153:PNUC RS08855
gene id: 312153:PNUC_RS08855
uniprot id: A4SZK1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

312153:PNUC RS09330
gene id: 312153:PNUC_RS09330
uniprot id: A4SZU6
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

312153:PNUC RS00990
gene id: 312153:PNUC_RS00990
uniprot id: A4SV91
names: Similarity
messages: Belongs to the peptidase A24 family.

312153:PNUC RS09050
gene id: 312153:PNUC_RS09050
uniprot id: A4SZP0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

312153:PNUC RS08340
gene id: 312153:PNUC_RS08340
uniprot id: A4SZA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

312153:PNUC RS04260
gene id: 312153:PNUC_RS04260
uniprot id: A4SX23
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS06715
gene id: 312153:PNUC_RS06715
uniprot id: A4SYD0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the malate synthase family. GlcB subfamily.
messages: Cytoplasm
messages: Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

312153:PNUC RS01090
gene id: 312153:PNUC_RS01090
uniprot id: A4SVB1
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

312153:PNUC RS01045
gene id: 312153:PNUC_RS01045
uniprot id: A4SVA2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

312153:PNUC RS03915
gene id: 312153:PNUC_RS03915
uniprot id: A4SWV4
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

312153:PNUC RS00390
gene id: 312153:PNUC_RS00390
uniprot id: A4SUX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

312153:PNUC RS01955
gene id: 312153:PNUC_RS01955
uniprot id: A4SVS9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

312153:PNUC RS01235
gene id: 312153:PNUC_RS01235
uniprot id: A4SVD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

312153:PNUC RS07875
gene id: 312153:PNUC_RS07875
uniprot id: A4SZ07
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS06155
gene id: 312153:PNUC_RS06155
uniprot id: A4SY23
names: Subcellular Location Annotation
messages: Cell inner membrane

312153:PNUC RS01865
gene id: 312153:PNUC_RS01865
uniprot id: A4SVR1
names: Similarity
messages: Belongs to the leucine-binding protein family.

312153:PNUC RS03955
gene id: 312153:PNUC_RS03955
uniprot id: A4SWW2
names: Cofactor
names: Subunit
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.
messages: The heme is bound between the two transmembrane subunits.

312153:PNUC RS07215
gene id: 312153:PNUC_RS07215
uniprot id: A4SYM7
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

312153:PNUC RS07880
gene id: 312153:PNUC_RS07880
uniprot id: A4SZ08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

312153:PNUC RS04385
gene id: 312153:PNUC_RS04385
uniprot id: A4SX46
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

312153:PNUC RS07665
gene id: 312153:PNUC_RS07665
uniprot id: A4SYW5
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS02980
gene id: 312153:PNUC_RS02980
uniprot id: A4SWC6
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS00640
gene id: 312153:PNUC_RS00640
uniprot id: A4SV25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

312153:PNUC RS03800
gene id: 312153:PNUC_RS03800
uniprot id: A4SWT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PsiE family.
messages: Cell inner membrane
messages: Membrane

312153:PNUC RS10045
gene id: 312153:PNUC_RS10045
uniprot id: A4T086
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX11/CtaG family.
messages: Cell inner membrane
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.

312153:PNUC RS04600
gene id: 312153:PNUC_RS04600
uniprot id: A4SX86
names: Similarity
messages: Belongs to the IlvD/Edd family.

312153:PNUC RS04480
gene id: 312153:PNUC_RS04480
uniprot id: A4SX66
names: Similarity
messages: Belongs to the aspartokinase family.

312153:PNUC RS07625
gene id: 312153:PNUC_RS07625
uniprot id: A4SYV8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

312153:PNUC RS01400
gene id: 312153:PNUC_RS01400
uniprot id: A4SVH2
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

312153:PNUC RS10380
gene id: 312153:PNUC_RS10380
uniprot id: A4T0F3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

312153:PNUC RS00010
gene id: 312153:PNUC_RS00010
uniprot id: A4SUR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

312153:PNUC RS01870
gene id: 312153:PNUC_RS01870
uniprot id: A4SVR2
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS03315
gene id: 312153:PNUC_RS03315
uniprot id: A4SWI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

312153:PNUC RS04585
gene id: 312153:PNUC_RS04585
uniprot id: A4SX83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

312153:PNUC RS04150
gene id: 312153:PNUC_RS04150
uniprot id: A4SX01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the high-potential iron-sulfur protein (HiPIP) family.
messages: Homodimer.
messages: Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria.

312153:PNUC RS00645
gene id: 312153:PNUC_RS00645
uniprot id: A4SV26
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

312153:PNUC RS03395
gene id: 312153:PNUC_RS03395
uniprot id: A4SWK5
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

312153:PNUC RS10565
gene id: 312153:PNUC_RS10565
uniprot id: A4T0I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

312153:PNUC RS02605
gene id: 312153:PNUC_RS02605
uniprot id: A4SW55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

312153:PNUC RS03205
gene id: 312153:PNUC_RS03205
uniprot id: A4SWG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

312153:PNUC RS00460
gene id: 312153:PNUC_RS00460
uniprot id: A4SUY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Membrane

312153:PNUC RS10010
gene id: 312153:PNUC_RS10010
uniprot id: A4T079
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.

312153:PNUC RS03970
gene id: 312153:PNUC_RS03970
uniprot id: A4SWW5
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

312153:PNUC RS09435
gene id: 312153:PNUC_RS09435
uniprot id: A4SZW7
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

312153:PNUC RS02360
gene id: 312153:PNUC_RS02360
uniprot id: A4SW06
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS05640
gene id: 312153:PNUC_RS05640
uniprot id: A4SXT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

312153:PNUC RS01535
gene id: 312153:PNUC_RS01535
uniprot id: A4SVJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

312153:PNUC RS00870
gene id: 312153:PNUC_RS00870
uniprot id: A4SV67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsL family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Membrane
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

312153:PNUC RS02110
gene id: 312153:PNUC_RS02110
uniprot id: A4SVV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Periplasm

312153:PNUC RS06110
gene id: 312153:PNUC_RS06110
uniprot id: A4SY14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

312153:PNUC RS03125
gene id: 312153:PNUC_RS03125
uniprot id: A4SWF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

312153:PNUC RS09605
gene id: 312153:PNUC_RS09605
uniprot id: A4SZZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

312153:PNUC RS03960
gene id: 312153:PNUC_RS03960
uniprot id: A4SWW3
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.
messages: The heme is bound between the two transmembrane subunits.

312153:PNUC RS05395
gene id: 312153:PNUC_RS05395
uniprot id: A4SXN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

312153:PNUC RS09005
gene id: 312153:PNUC_RS09005
uniprot id: A4SZN1
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

312153:PNUC RS02300
gene id: 312153:PNUC_RS02300
uniprot id: A4SVZ4
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

312153:PNUC RS05510
gene id: 312153:PNUC_RS05510
uniprot id: A4SXQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

312153:PNUC RS05350
gene id: 312153:PNUC_RS05350
uniprot id: A4SXM6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

312153:PNUC RS00485
gene id: 312153:PNUC_RS00485
uniprot id: A4SUZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

312153:PNUC RS03735
gene id: 312153:PNUC_RS03735
uniprot id: A4SWR8
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

312153:PNUC RS08840
gene id: 312153:PNUC_RS08840
uniprot id: A4SZJ8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

312153:PNUC RS02100
gene id: 312153:PNUC_RS02100
uniprot id: A4SVV7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

312153:PNUC RS01735
gene id: 312153:PNUC_RS01735
uniprot id: A4SVN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

312153:PNUC RS06290
gene id: 312153:PNUC_RS06290
uniprot id: A4SY48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

312153:PNUC RS05615
gene id: 312153:PNUC_RS05615
uniprot id: A4SXS7
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family. GreB subfamily.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.

312153:PNUC RS04475
gene id: 312153:PNUC_RS04475
uniprot id: A4SX65
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

312153:PNUC RS06630
gene id: 312153:PNUC_RS06630
uniprot id: A4SYB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

312153:PNUC RS08085
gene id: 312153:PNUC_RS08085
uniprot id: A4SZ49
names: Similarity
messages: Belongs to the leucine-binding protein family.

312153:PNUC RS04220
gene id: 312153:PNUC_RS04220
uniprot id: A4SX15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

312153:PNUC RS00695
gene id: 312153:PNUC_RS00695
uniprot id: A4SV35
names: Similarity
messages: Belongs to the GST superfamily. HSP26 family.

312153:PNUC RS09720
gene id: 312153:PNUC_RS09720
uniprot id: A4T022
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

312153:PNUC RS04745
gene id: 312153:PNUC_RS04745
uniprot id: A4SXB3
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

312153:PNUC RS09020
gene id: 312153:PNUC_RS09020
uniprot id: A4SZN4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

312153:PNUC RS04525
gene id: 312153:PNUC_RS04525
uniprot id: A4SX72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

312153:PNUC RS01055
gene id: 312153:PNUC_RS01055
uniprot id: A4SVA4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS00110
gene id: 312153:PNUC_RS00110
uniprot id: A4SUT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

312153:PNUC RS07735
gene id: 312153:PNUC_RS07735
uniprot id: A4SYX9
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

312153:PNUC RS01305
gene id: 312153:PNUC_RS01305
uniprot id: A4SVF3
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

312153:PNUC RS04035
gene id: 312153:PNUC_RS04035
uniprot id: A4SWX8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

312153:PNUC RS03845
gene id: 312153:PNUC_RS03845
uniprot id: A4SWU0
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

312153:PNUC RS06425
gene id: 312153:PNUC_RS06425
uniprot id: A4SY74
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS04755
gene id: 312153:PNUC_RS04755
uniprot id: A4SXB5
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.

312153:PNUC RS10560
gene id: 312153:PNUC_RS10560
uniprot id: A4T0I7
names: Similarity
messages: Belongs to the MipA/OmpV family.

312153:PNUC RS05175
gene id: 312153:PNUC_RS05175
uniprot id: A4SXJ3
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

312153:PNUC RS00240
gene id: 312153:PNUC_RS00240
uniprot id: A4SUU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

312153:PNUC RS06855
gene id: 312153:PNUC_RS06855
uniprot id: A4SYF7
names: Similarity
messages: Belongs to the thioredoxin family.

312153:PNUC RS00275
gene id: 312153:PNUC_RS00275
uniprot id: A4SUV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

312153:PNUC RS09060
gene id: 312153:PNUC_RS09060
uniprot id: A4SZP2
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

312153:PNUC RS00310
gene id: 312153:PNUC_RS00310
uniprot id: A4SUW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

312153:PNUC RS02390
gene id: 312153:PNUC_RS02390
uniprot id: A4SW12
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CcoP / FixP family.
messages: Binds 2 heme C groups per subunit.
messages: C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.
messages: Cell inner membrane
messages: Component of the cbb3-type cytochrome c oxidase.

312153:PNUC RS08145
gene id: 312153:PNUC_RS08145
uniprot id: A4SZ61
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS03450
gene id: 312153:PNUC_RS03450
uniprot id: A4SWL6
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

312153:PNUC RS07305
gene id: 312153:PNUC_RS07305
uniprot id: A4SYP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

312153:PNUC RS00875
gene id: 312153:PNUC_RS00875
uniprot id: A4SV68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
messages: Cell inner membrane

312153:PNUC RS03575
gene id: 312153:PNUC_RS03575
uniprot id: A4SWN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

312153:PNUC RS09095
gene id: 312153:PNUC_RS09095
uniprot id: A4SZP9
names: Subcellular Location Annotation
messages: Cytoplasm

312153:PNUC RS06455
gene id: 312153:PNUC_RS06455
uniprot id: A4SY80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

312153:PNUC RS10805
gene id: 312153:PNUC_RS10805
uniprot id: A4T0N5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

312153:PNUC RS03710
gene id: 312153:PNUC_RS03710
uniprot id: A4SWR4
names: Similarity
messages: Belongs to the YjdM family.

312153:PNUC RS00730
gene id: 312153:PNUC_RS00730
uniprot id: A4SV41
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.

312153:PNUC RS02345
gene id: 312153:PNUC_RS02345
uniprot id: A4SW03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.

312153:PNUC RS08330
gene id: 312153:PNUC_RS08330
uniprot id: A4SZ98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

312153:PNUC RS08425
gene id: 312153:PNUC_RS08425
uniprot id: A4SZB8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

312153:PNUC RS03220
gene id: 312153:PNUC_RS03220
uniprot id: A4SWH1
names: Similarity
messages: Belongs to the GARS family.

312153:PNUC RS08625
gene id: 312153:PNUC_RS08625
uniprot id: A4SZF7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

312153:PNUC RS06450
gene id: 312153:PNUC_RS06450
uniprot id: A4SY79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

312153:PNUC RS07035
gene id: 312153:PNUC_RS07035
uniprot id: A4SYJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. RhlE subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

312153:PNUC RS07585
gene id: 312153:PNUC_RS07585
uniprot id: A4SYV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

312153:PNUC RS07500
gene id: 312153:PNUC_RS07500
uniprot id: A4SYT3
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

312153:PNUC RS01025
gene id: 312153:PNUC_RS01025
uniprot id: A4SV98
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

312153:PNUC RS04015
gene id: 312153:PNUC_RS04015
uniprot id: A4SWX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.

312153:PNUC RS02735
gene id: 312153:PNUC_RS02735
uniprot id: A4SW81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

312153:PNUC RS05540
gene id: 312153:PNUC_RS05540
uniprot id: A4SXR3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

312153:PNUC RS10765
gene id: 312153:PNUC_RS10765
uniprot id: A4T0M5
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

312153:PNUC RS09405
gene id: 312153:PNUC_RS09405
uniprot id: A4SZW1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS03120
gene id: 312153:PNUC_RS03120
uniprot id: A4SWF1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

312153:PNUC RS02505
gene id: 312153:PNUC_RS02505
uniprot id: A4SW35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

312153:PNUC RS10165
gene id: 312153:PNUC_RS10165
uniprot id: A4T0B0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

312153:PNUC RS05990
gene id: 312153:PNUC_RS05990
uniprot id: A4SXZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

312153:PNUC RS03195
gene id: 312153:PNUC_RS03195
uniprot id: A4SWG6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

312153:PNUC RS06435
gene id: 312153:PNUC_RS06435
uniprot id: A4SY76
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

312153:PNUC RS07050
gene id: 312153:PNUC_RS07050
uniprot id: A4SYJ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

312153:PNUC RS01290
gene id: 312153:PNUC_RS01290
uniprot id: A4SVF0
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

312153:PNUC RS01920
gene id: 312153:PNUC_RS01920
uniprot id: A4SVS2
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

312153:PNUC RS08310
gene id: 312153:PNUC_RS08310
uniprot id: A4SZ95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Cell inner membrane
messages: Membrane

312153:PNUC RS10135
gene id: 312153:PNUC_RS10135
uniprot id: A4T0A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

312153:PNUC RS07420
gene id: 312153:PNUC_RS07420
uniprot id: A4SYR7
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

312153:PNUC RS10585
gene id: 312153:PNUC_RS10585
uniprot id: A4T0J3
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.
messages: Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids.

312153:PNUC RS09465
gene id: 312153:PNUC_RS09465
uniprot id: A4SZX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

312153:PNUC RS09645
gene id: 312153:PNUC_RS09645
uniprot id: A4T007
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

312153:PNUC RS02650
gene id: 312153:PNUC_RS02650
uniprot id: A4SW64
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

312153:PNUC RS08100
gene id: 312153:PNUC_RS08100
uniprot id: A4SZ52
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

312153:PNUC RS07255
gene id: 312153:PNUC_RS07255
uniprot id: A4SYN5
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

312153:PNUC RS05320
gene id: 312153:PNUC_RS05320
uniprot id: A4SXM0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS06865
gene id: 312153:PNUC_RS06865
uniprot id: A4SYF9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

312153:PNUC RS05435
gene id: 312153:PNUC_RS05435
uniprot id: A4SXP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

312153:PNUC RS10405
gene id: 312153:PNUC_RS10405
uniprot id: A4T0F8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.

312153:PNUC RS00435
gene id: 312153:PNUC_RS00435
uniprot id: A4SUY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

312153:PNUC RS11170
gene id: 312153:PNUC_RS11170
uniprot id: A4T0E4
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

312153:PNUC RS02725
gene id: 312153:PNUC_RS02725
uniprot id: A4SW79
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

312153:PNUC RS01710
gene id: 312153:PNUC_RS01710
uniprot id: A4SVN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

312153:PNUC RS08685
gene id: 312153:PNUC_RS08685
uniprot id: A4SZG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell inner membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

312153:PNUC RS01440
gene id: 312153:PNUC_RS01440
uniprot id: A4SVI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

312153:PNUC RS06945
gene id: 312153:PNUC_RS06945
uniprot id: A4SYH4
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.
messages: Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids.

312153:PNUC RS00895
gene id: 312153:PNUC_RS00895
uniprot id: A4SV72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

312153:PNUC RS04365
gene id: 312153:PNUC_RS04365
uniprot id: A4SX42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone-like protein H-NS family.
messages: nucleoid

312153:PNUC RS10575
gene id: 312153:PNUC_RS10575
uniprot id: A4T0J1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.

312153:PNUC RS10475
gene id: 312153:PNUC_RS10475
uniprot id: A4T0H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

312153:PNUC RS05205
gene id: 312153:PNUC_RS05205
uniprot id: A4SXJ9
names: Similarity
messages: Belongs to the CmpA/NrtA family.

312153:PNUC RS03875
gene id: 312153:PNUC_RS03875
uniprot id: A4SWU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-transferase family. Bpt subfamily.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.

312153:PNUC RS00050
gene id: 312153:PNUC_RS00050
uniprot id: A4SUR8
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS03470
gene id: 312153:PNUC_RS03470
uniprot id: A4SWM0
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

312153:PNUC RS08060
gene id: 312153:PNUC_RS08060
uniprot id: A4SZ44
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS02125
gene id: 312153:PNUC_RS02125
uniprot id: A4SVW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

312153:PNUC RS02205
gene id: 312153:PNUC_RS02205
uniprot id: A4SVX6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

312153:PNUC RS02200
gene id: 312153:PNUC_RS02200
uniprot id: A4SVX5
names: Similarity
messages: Belongs to the asparaginase 1 family.

312153:PNUC RS07360
gene id: 312153:PNUC_RS07360
uniprot id: A4SYQ5
names: Similarity
messages: Belongs to the UPF0111 family.

312153:PNUC RS01035
gene id: 312153:PNUC_RS01035
uniprot id: A4SVA0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

312153:PNUC RS06355
gene id: 312153:PNUC_RS06355
uniprot id: A4SY61
names: Similarity
messages: Belongs to the glutamate synthase family.

312153:PNUC RS04280
gene id: 312153:PNUC_RS04280
uniprot id: A4SX27
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 nickel ion per subunit.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

312153:PNUC RS03385
gene id: 312153:PNUC_RS03385
uniprot id: A4SWK3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS09305
gene id: 312153:PNUC_RS09305
uniprot id: A4SZU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

312153:PNUC RS04830
gene id: 312153:PNUC_RS04830
uniprot id: A4SXD0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

312153:PNUC RS02455
gene id: 312153:PNUC_RS02455
uniprot id: A4SW25
names: Similarity
messages: Belongs to the DapA family.

312153:PNUC RS06135
gene id: 312153:PNUC_RS06135
uniprot id: A4SY19
names: Similarity
messages: Belongs to the glycosyl hydrolase 8 (cellulase D) family.

312153:PNUC RS00450
gene id: 312153:PNUC_RS00450
uniprot id: A4SUY7
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

312153:PNUC RS09155
gene id: 312153:PNUC_RS09155
uniprot id: A4SZR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

312153:PNUC RS09940
gene id: 312153:PNUC_RS09940
uniprot id: A4T066
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolB family.
messages: Cell outer membrane
messages: Membrane
messages: Monomer.

312153:PNUC RS07030
gene id: 312153:PNUC_RS07030
uniprot id: A4SYJ1
names: Similarity
messages: Belongs to the cysteine dioxygenase family.

312153:PNUC RS02675
gene id: 312153:PNUC_RS02675
uniprot id: A4SW69
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

312153:PNUC RS09180
gene id: 312153:PNUC_RS09180
uniprot id: A4SZR6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

312153:PNUC RS05445
gene id: 312153:PNUC_RS05445
uniprot id: A4SXP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

312153:PNUC RS01675
gene id: 312153:PNUC_RS01675
uniprot id: A4SVM6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

312153:PNUC RS02460
gene id: 312153:PNUC_RS02460
uniprot id: A4SW26
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

312153:PNUC RS00590
gene id: 312153:PNUC_RS00590
uniprot id: A4SV15
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

312153:PNUC RS04380
gene id: 312153:PNUC_RS04380
uniprot id: A4SX45
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

312153:PNUC RS08410
gene id: 312153:PNUC_RS08410
uniprot id: A4SZB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

312153:PNUC RS09265
gene id: 312153:PNUC_RS09265
uniprot id: A4SZT3
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

312153:PNUC RS01225
gene id: 312153:PNUC_RS01225
uniprot id: A4SVD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamE family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

312153:PNUC RS07915
gene id: 312153:PNUC_RS07915
uniprot id: A4SZ15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmD/CycX/HelD family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

312153:PNUC RS05115
gene id: 312153:PNUC_RS05115
uniprot id: A4SXI2
names: Similarity
messages: Belongs to the WrbA family.

312153:PNUC RS00850
gene id: 312153:PNUC_RS00850
uniprot id: A4SV63
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

312153:PNUC RS03790
gene id: 312153:PNUC_RS03790
uniprot id: A4SWS9
names: Similarity
messages: Belongs to the pirin family.

312153:PNUC RS09960
gene id: 312153:PNUC_RS09960
uniprot id: A4T069
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

312153:PNUC RS00430
gene id: 312153:PNUC_RS00430
uniprot id: A4SUY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

312153:PNUC RS07650
gene id: 312153:PNUC_RS07650
uniprot id: A4SYW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell inner membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

312153:PNUC RS00330
gene id: 312153:PNUC_RS00330
uniprot id: A4SUW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

312153:PNUC RS01750
gene id: 312153:PNUC_RS01750
uniprot id: A4SVP0
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

312153:PNUC RS02070
gene id: 312153:PNUC_RS02070
uniprot id: A4SVV1
names: Function
names: Similarity
messages: Belongs to the DUF177 domain family.
messages: Plays a role in synthesis, processing and/or stability of 23S rRNA.

312153:PNUC RS10385
gene id: 312153:PNUC_RS10385
uniprot id: A4T0F4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

312153:PNUC RS05480
gene id: 312153:PNUC_RS05480
uniprot id: A4SXQ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).

312153:PNUC RS01240
gene id: 312153:PNUC_RS01240
uniprot id: A4SVE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LptE lipoprotein family.
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.
messages: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.

312153:PNUC RS06575
gene id: 312153:PNUC_RS06575
uniprot id: A4SYA3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

312153:PNUC RS06125
gene id: 312153:PNUC_RS06125
uniprot id: A4SY17
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS00125
gene id: 312153:PNUC_RS00125
uniprot id: A4SUT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

312153:PNUC RS09780
gene id: 312153:PNUC_RS09780
uniprot id: A4T034
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

312153:PNUC RS09110
gene id: 312153:PNUC_RS09110
uniprot id: A4SZQ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

312153:PNUC RS10115
gene id: 312153:PNUC_RS10115
uniprot id: A4T0A0
names: Subcellular Location Annotation
messages: Cytoplasm

312153:PNUC RS02135
gene id: 312153:PNUC_RS02135
uniprot id: A4SVW4
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

312153:PNUC RS09790
gene id: 312153:PNUC_RS09790
uniprot id: A4T036
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS03380
gene id: 312153:PNUC_RS03380
uniprot id: A4SWK2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

312153:PNUC RS00400
gene id: 312153:PNUC_RS00400
uniprot id: A4SUX8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

312153:PNUC RS06730
gene id: 312153:PNUC_RS06730
uniprot id: A4SYD3
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

312153:PNUC RS09090
gene id: 312153:PNUC_RS09090
uniprot id: A4SZP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

312153:PNUC RS04020
gene id: 312153:PNUC_RS04020
uniprot id: A4SWX5
names: Similarity
messages: Belongs to the TrpF family.

312153:PNUC RS07535
gene id: 312153:PNUC_RS07535
uniprot id: A4SYU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

312153:PNUC RS06915
gene id: 312153:PNUC_RS06915
uniprot id: A4SYG8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

312153:PNUC RS09985
gene id: 312153:PNUC_RS09985
uniprot id: A4T074
names: Similarity
messages: Belongs to the peptidase M16 family.

312153:PNUC RS10620
gene id: 312153:PNUC_RS10620
uniprot id: A4T0K0
names: Function
names: Similarity
messages: Belongs to the catalase family.
messages: Has an organic peroxide-dependent peroxidase activity.

312153:PNUC RS00090
gene id: 312153:PNUC_RS00090
uniprot id: A4SUS6
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

312153:PNUC RS05355
gene id: 312153:PNUC_RS05355
uniprot id: A4SXM7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

312153:PNUC RS06210
gene id: 312153:PNUC_RS06210
uniprot id: A4SY33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

312153:PNUC RS06625
gene id: 312153:PNUC_RS06625
uniprot id: A4SYB3
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.

312153:PNUC RS00975
gene id: 312153:PNUC_RS00975
uniprot id: A4SV88
names: Similarity
messages: Belongs to the Nudix hydrolase family.

312153:PNUC RS06900
gene id: 312153:PNUC_RS06900
uniprot id: A4SYG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0065 (bug) family.
messages: Periplasm

312153:PNUC RS04075
gene id: 312153:PNUC_RS04075
uniprot id: A4SWY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

312153:PNUC RS01405
gene id: 312153:PNUC_RS01405
uniprot id: A4SVH3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

312153:PNUC RS04345
gene id: 312153:PNUC_RS04345
uniprot id: A4SX39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

312153:PNUC RS01380
gene id: 312153:PNUC_RS01380
uniprot id: A4SVG8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

312153:PNUC RS08295
gene id: 312153:PNUC_RS08295
uniprot id: A4SZ92
names: Similarity
messages: Belongs to the alkaline phosphatase family.

312153:PNUC RS03330
gene id: 312153:PNUC_RS03330
uniprot id: A4SWJ2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CoA-transferase III family. Frc subfamily.
messages: Homodimer.
messages: Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

312153:PNUC RS02545
gene id: 312153:PNUC_RS02545
uniprot id: A4SW43
names: Similarity
messages: Belongs to the pirin family.

312153:PNUC RS07450
gene id: 312153:PNUC_RS07450
uniprot id: A4SYS3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

312153:PNUC RS05300
gene id: 312153:PNUC_RS05300
uniprot id: A4SXL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

312153:PNUC RS10770
gene id: 312153:PNUC_RS10770
uniprot id: A4T0M6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

312153:PNUC RS03090
gene id: 312153:PNUC_RS03090
uniprot id: A4SWE6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

312153:PNUC RS02750
gene id: 312153:PNUC_RS02750
uniprot id: A4SW84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 7 family.
messages: Homodimer.
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: Periplasm

312153:PNUC RS02130
gene id: 312153:PNUC_RS02130
uniprot id: A4SVW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

312153:PNUC RS00610
gene id: 312153:PNUC_RS00610
uniprot id: A4SV19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

312153:PNUC RS08930
gene id: 312153:PNUC_RS08930
uniprot id: A4SZL6
names: Similarity
messages: Belongs to the UDPGP type 2 family.

312153:PNUC RS02575
gene id: 312153:PNUC_RS02575
uniprot id: A4SW49
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

312153:PNUC RS03815
gene id: 312153:PNUC_RS03815
uniprot id: A4SWT4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

312153:PNUC RS10430
gene id: 312153:PNUC_RS10430
uniprot id: A4T0G3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

312153:PNUC RS04650
gene id: 312153:PNUC_RS04650
uniprot id: A4SX95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

312153:PNUC RS09715
gene id: 312153:PNUC_RS09715
uniprot id: A4T021
names: Similarity
messages: Belongs to the peptidase M24B family.

312153:PNUC RS08725
gene id: 312153:PNUC_RS08725
uniprot id: A4SZH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

312153:PNUC RS00455
gene id: 312153:PNUC_RS00455
uniprot id: A4SUY8
names: Similarity
messages: Belongs to the CutA family.

312153:PNUC RS04820
gene id: 312153:PNUC_RS04820
uniprot id: A4SXC8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

312153:PNUC RS07920
gene id: 312153:PNUC_RS07920
uniprot id: A4SZ16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

312153:PNUC RS08940
gene id: 312153:PNUC_RS08940
uniprot id: A4SZL8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

312153:PNUC RS10005
gene id: 312153:PNUC_RS10005
uniprot id: A4T078
names: Similarity
messages: Belongs to the SCO1/2 family.

312153:PNUC RS10075
gene id: 312153:PNUC_RS10075
uniprot id: A4T092
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

312153:PNUC RS02610
gene id: 312153:PNUC_RS02610
uniprot id: A4SW56
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

312153:PNUC RS08130
gene id: 312153:PNUC_RS08130
uniprot id: A4SZ58
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

312153:PNUC RS03265
gene id: 312153:PNUC_RS03265
uniprot id: A4SWH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

312153:PNUC RS02025
gene id: 312153:PNUC_RS02025
uniprot id: A4SVU2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

312153:PNUC RS09600
gene id: 312153:PNUC_RS09600
uniprot id: A4SZZ8
names: Subcellular Location Annotation
messages: Membrane

312153:PNUC RS06775
gene id: 312153:PNUC_RS06775
uniprot id: A4SYE2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

312153:PNUC RS00680
gene id: 312153:PNUC_RS00680
uniprot id: A4SV32
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

312153:PNUC RS07270
gene id: 312153:PNUC_RS07270
uniprot id: A4SYN8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

312153:PNUC RS07545
gene id: 312153:PNUC_RS07545
uniprot id: A4SYU2
names: Similarity
messages: Belongs to the skp family.

312153:PNUC RS00265
gene id: 312153:PNUC_RS00265
uniprot id: A4SUV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

312153:PNUC RS01640
gene id: 312153:PNUC_RS01640
uniprot id: A4SVL9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

312153:PNUC RS07900
gene id: 312153:PNUC_RS07900
uniprot id: A4SZ12
names: Similarity
messages: Belongs to the thioredoxin family. DsbE subfamily.

312153:PNUC RS06005
gene id: 312153:PNUC_RS06005
uniprot id: A4SXZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

312153:PNUC RS02515
gene id: 312153:PNUC_RS02515
uniprot id: A4SW37
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

312153:PNUC RS00910
gene id: 312153:PNUC_RS00910
uniprot id: A4SV75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

312153:PNUC RS05800
gene id: 312153:PNUC_RS05800
uniprot id: A4SXW1
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

312153:PNUC RS01120
gene id: 312153:PNUC_RS01120
uniprot id: A4SVB6
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

312153:PNUC RS00905
gene id: 312153:PNUC_RS00905
uniprot id: A4SV74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

312153:PNUC RS01465
gene id: 312153:PNUC_RS01465
uniprot id: A4SVI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

312153:PNUC RS10365
gene id: 312153:PNUC_RS10365
uniprot id: A4T0F0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.