300852:TTH RS02215
gene id: 300852:TTH_RS02215
uniprot id: Q60049
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the nitroreductase family.
messages: Binds 1 FMN per subunit.
messages: Can oxidize either NADH or NADPH with a preference for NADH. Can catalyze electron transfer from NADH to various electron acceptors which include, in addition to molecular oxygen, cytochrome c, 2,6 dichlorphenolindophenol, methylene blue, ferricyanide or P-nitroblue tetrazolium.
messages: Homodimer.

300852:TTH RS01150
gene id: 300852:TTH_RS01150
uniprot id: Q5SLS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

300852:TTH RS02725
gene id: 300852:TTH_RS02725
uniprot id: Q5SKX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

300852:TTH RS07390
gene id: 300852:TTH_RS07390
uniprot id: Q5SIB4
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS02935
gene id: 300852:TTH_RS02935
uniprot id: Q5SKT0
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

300852:TTH RS11115
gene id: 300852:TTH_RS11115
uniprot id: Q53VV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

300852:TTH RS05775
gene id: 300852:TTH_RS05775
uniprot id: Q5SJ77
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS01840
gene id: 300852:TTH_RS01840
uniprot id: Q5SLE3
names: Similarity
messages: Belongs to the universal stress protein A family.

300852:TTH RS00560
gene id: 300852:TTH_RS00560
uniprot id: Q5SM36
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS05460
gene id: 300852:TTH_RS05460
uniprot id: Q5SJE1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

300852:TTH RS06860
gene id: 300852:TTH_RS06860
uniprot id: Q7SIA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CutA family.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in resistance toward heavy metals.

300852:TTH RS08450
gene id: 300852:TTH_RS08450
uniprot id: Q5SHR0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

300852:TTH RS07010
gene id: 300852:TTH_RS07010
uniprot id: Q5SII5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

300852:TTH RS07880
gene id: 300852:TTH_RS07880
uniprot id: P29253
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

300852:TTH RS07720
gene id: 300852:TTH_RS07720
uniprot id: Q5SI55
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

300852:TTH RS10290
gene id: 300852:TTH_RS10290
uniprot id: Q53WA2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

300852:TTH RS02090
gene id: 300852:TTH_RS02090
uniprot id: Q5SL93
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

300852:TTH RS02305
gene id: 300852:TTH_RS02305
uniprot id: Q5SL50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

300852:TTH RS09600
gene id: 300852:TTH_RS09600
uniprot id: Q5SH37
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms trimers in the presence of calcium.
messages: S-layer
messages: The S-layer is a paracrystalline mono-layered assembly of proteins which coat the surface of bacteria.

300852:TTH RS09560
gene id: 300852:TTH_RS09560
uniprot id: Q5SH44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

300852:TTH RS01895
gene id: 300852:TTH_RS01895
uniprot id: Q5SLD1
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

300852:TTH RS02270
gene id: 300852:TTH_RS02270
uniprot id: Q5SL57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

300852:TTH RS06850
gene id: 300852:TTH_RS06850
uniprot id: Q5SIL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

300852:TTH RS01225
gene id: 300852:TTH_RS01225
uniprot id: Q5SJJ0
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

300852:TTH RS00480
gene id: 300852:TTH_RS00480
uniprot id: Q56224
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit. The [4Fe-4S] clusters are referred to as N6a and N6b.
messages: Cell membrane
messages: NDH-1 is composed of 15 different subunits, Nqo1 to Nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8 and Nqo10 to Nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9 and Nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP. The role of the Nqo9 subunit appears to provide a 'connecting chain' of two clusters between cluster N5 and the terminal cluster N2, and to stabilize the structure of the complex by interacting with other subunits.

300852:TTH RS04960
gene id: 300852:TTH_RS04960
uniprot id: Q5SJN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

300852:TTH RS05250
gene id: 300852:TTH_RS05250
uniprot id: P60490
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: Contacts the 16S rRNA of the 30S subunit (part of bridge B6), connecting the 2 subunits.
messages: Part of the 50S risobomal subunit. Contacts protein L14. Forms a bridge to the 30S subunit in the 70S ribosome, contacting the 16S rRNA.

300852:TTH RS02025
gene id: 300852:TTH_RS02025
uniprot id: Q5SLA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

300852:TTH RS11245
gene id: 300852:TTH_RS11245
uniprot id: Q53WH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetaldehyde dehydrogenase family.
messages: Catalyzes the conversion of acetaldehyde or propanal to acetyl-CoA or propanoyl-CoA, respectively, using NAD(+) and coenzyme A. The aldehyde substrates can be directly channeled from the aldolase TTHB246 to the dehydrogenase TTHB247. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
messages: Monomer. Can also form a heterotetramer composed of two aldolase (TTHB246) and two dehydrogenase (TTHB247) subunits. Upon complex formation, the aldolase shows a 5-fold increase in substrate affinity, while the dehydrogenase shows a 3-fold decrease; the kcat values of each enzyme are reduced by 2-fold when they are in a complex.

300852:TTH RS07445
gene id: 300852:TTH_RS07445
uniprot id: Q5SIA4
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

300852:TTH RS05790
gene id: 300852:TTH_RS05790
uniprot id: Q5SJ74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

300852:TTH RS05840
gene id: 300852:TTH_RS05840
uniprot id: Q5SJ64
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

300852:TTH RS01125
gene id: 300852:TTH_RS01125
uniprot id: Q5SLS7
names: Similarity
messages: Belongs to the AlaDH/PNT family.

300852:TTH RS00435
gene id: 300852:TTH_RS00435
uniprot id: Q5SM60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

300852:TTH RS04980
gene id: 300852:TTH_RS04980
uniprot id: Q5SJM8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS03980
gene id: 300852:TTH_RS03980
uniprot id: Q5SK81
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS08495
gene id: 300852:TTH_RS08495
uniprot id: P0DOY6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S3 and S10, which cover it.
messages: Required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity). Binds 16S rRNA in center of the 30S subunit head.

300852:TTH RS08960
gene id: 300852:TTH_RS08960
uniprot id: Q5SHG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

300852:TTH RS00125
gene id: 300852:TTH_RS00125
uniprot id: Q5SMC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

300852:TTH RS09530
gene id: 300852:TTH_RS09530
uniprot id: Q5SH50
names: Similarity
messages: Belongs to the Nudix hydrolase family.

300852:TTH RS01680
gene id: 300852:TTH_RS01680
uniprot id: Q5SLH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

300852:TTH RS06470
gene id: 300852:TTH_RS06470
uniprot id: P74901
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

300852:TTH RS09460
gene id: 300852:TTH_RS09460
uniprot id: Q5SH65
names: Similarity
messages: Belongs to the peptidase S8 family.

300852:TTH RS09505
gene id: 300852:TTH_RS09505
uniprot id: P56881
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The C-terminal domain recognizes the anticodon bases.

300852:TTH RS07435
gene id: 300852:TTH_RS07435
uniprot id: Q5SIA6
names: Similarity
messages: Belongs to the glutamate synthase family.

300852:TTH RS03840
gene id: 300852:TTH_RS03840
uniprot id: Q5SKA9
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

300852:TTH RS10150
gene id: 300852:TTH_RS10150
uniprot id: Q53WD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YdjC deacetylase family.
messages: Homodimer.
messages: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

300852:TTH RS06645
gene id: 300852:TTH_RS06645
uniprot id: Q5SIQ7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

300852:TTH RS01495
gene id: 300852:TTH_RS01495
uniprot id: Q5SLL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

300852:TTH RS02805
gene id: 300852:TTH_RS02805
uniprot id: Q5SKV5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

300852:TTH RS08500
gene id: 300852:TTH_RS08500
uniprot id: Q5SHQ0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: In PubMed:11154066 there is uncertainty about the number of Arg residues at position 10 and whether position 25 is Pro or Tyr.
messages: Note that in Ref.3 it was shown that the initiator methionine is not removed, in PubMed:11154066 it was shown the initiator methionine is removed, and the mass determined in PubMed:16287167 is compatible with initiator methionine removal.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 (TL5) subcomplex; has also been isolated as a complex with 5S rRNA, RL25 (TL5) and DNA binding protein II. Forms a bridge to the 30S subunit in the 70S ribosome, contacting protein S13; this bridge is straddled by the 5S rRNA. Contacts the P site tRNA.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (forming bridge B1b) connecting the head of the 30S subunit to the top of the 50S subunit. The bridge itself contacts the P site tRNA and is implicated in movement during ribosome translocation. Also contacts the P site tRNA independently of the intersubunit bridge; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

300852:TTH RS05420
gene id: 300852:TTH_RS05420
uniprot id: Q5SJE9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS04305
gene id: 300852:TTH_RS04305
uniprot id: Q5SK19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

300852:TTH RS07315
gene id: 300852:TTH_RS07315
uniprot id: Q5SIC9
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

300852:TTH RS05550
gene id: 300852:TTH_RS05550
uniprot id: Q5SJC4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

300852:TTH RS03300
gene id: 300852:TTH_RS03300
uniprot id: Q5SKL2
names: Similarity
messages: Belongs to the peptidase T1B family. HslV subfamily.

300852:TTH RS07420
gene id: 300852:TTH_RS07420
uniprot id: Q5SIA8
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate (PubMed:15296735). GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition (By similarity).
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (PubMed:15296735). Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates (By similarity).
messages: Homotetramer in the presence of UTP and ATP. Is in a protein concentration-dependent equilibrium between monomer, dimer, and tetramer in the absence of UTP and ATP.

300852:TTH RS08855
gene id: 300852:TTH_RS08855
uniprot id: Q5SHI3
names: Similarity
messages: Belongs to the thioredoxin family.

300852:TTH RS03750
gene id: 300852:TTH_RS03750
uniprot id: Q5SKC1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

300852:TTH RS04040
gene id: 300852:TTH_RS04040
uniprot id: Q5SK69
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

300852:TTH RS07225
gene id: 300852:TTH_RS07225
uniprot id: Q5SIE7
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

300852:TTH RS07495
gene id: 300852:TTH_RS07495
uniprot id: Q5SI94
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

300852:TTH RS10890
gene id: 300852:TTH_RS10890
uniprot id: Q53VZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

300852:TTH RS08425
gene id: 300852:TTH_RS08425
uniprot id: P80373
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Binds 1 zinc ion per subunit (PubMed:11866529). In a number of structures (e.g. 4Y4O, 5FDV) a 4Fe-4S cluster is seen in place of the zinc cofactor (PubMed:25775268, PubMed:26792896).
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the body and platform of the 30S subunit. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit (PubMed:11014182, PubMed:11007480, PubMed:11163189, PubMed:11014183, PubMed:11511350, PubMed:11296217, PubMed:11228145, PubMed:11228145, PubMed:11283358, PubMed:11340196, PubMed:11866529, PubMed:25775268, PubMed:26792896). Contacts protein S5 (PubMed:11340196). The interaction surface between S4 and S5 is involved in control of translational fidelity.

300852:TTH RS05260
gene id: 300852:TTH_RS05260
uniprot id: Q5SJH5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

300852:TTH RS06245
gene id: 300852:TTH_RS06245
uniprot id: Q9ZND4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

300852:TTH RS09175
gene id: 300852:TTH_RS09175
uniprot id: Q5SHC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

300852:TTH RS11035
gene id: 300852:TTH_RS11035
uniprot id: Q53VX2
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

300852:TTH RS07005
gene id: 300852:TTH_RS07005
uniprot id: Q5SII6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family.
messages: Cell outer membrane

300852:TTH RS09710
gene id: 300852:TTH_RS09710
uniprot id: Q5SH15
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

300852:TTH RS06480
gene id: 300852:TTH_RS06480
uniprot id: Q5SIT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

300852:TTH RS06595
gene id: 300852:TTH_RS06595
uniprot id: Q5SIR2
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS03180
gene id: 300852:TTH_RS03180
uniprot id: Q5SKN1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

300852:TTH RS03535
gene id: 300852:TTH_RS03535
uniprot id: Q5SKG5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

300852:TTH RS01140
gene id: 300852:TTH_RS01140
uniprot id: Q5SLS4
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

300852:TTH RS00460
gene id: 300852:TTH_RS00460
uniprot id: Q56221
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster. This [2Fe-2S] cluster is referred to as N1a.
messages: Cell membrane
messages: NDH-1 is composed of 15 different subunits, Nqo1 to Nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8 and Nqo10 to Nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9 and Nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP.
messages: The subunit can be divided into two domains: an N-terminal four-helical bundle (residues 2 to 74) involved in interactions with subunits Nqo1 and Nqo3, and a thioredoxin-like C-terminal domain (residues 75 to 180) that coordinates the binuclear cluster N1a.

300852:TTH RS01820
gene id: 300852:TTH_RS01820
uniprot id: Q5SLE7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

300852:TTH RS03160
gene id: 300852:TTH_RS03160
uniprot id: Q5SKN5
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

300852:TTH RS04085
gene id: 300852:TTH_RS04085
uniprot id: Q5SK63
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

300852:TTH RS08825
gene id: 300852:TTH_RS08825
uniprot id: Q5SHI7
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

300852:TTH RS07030
gene id: 300852:TTH_RS07030
uniprot id: Q5SII1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

300852:TTH RS05180
gene id: 300852:TTH_RS05180
uniprot id: Q5SJJ0
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

300852:TTH RS07860
gene id: 300852:TTH_RS07860
uniprot id: Q5SI28
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

300852:TTH RS02670
gene id: 300852:TTH_RS02670
uniprot id: Q5SKY1
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

300852:TTH RS00755
gene id: 300852:TTH_RS00755
uniprot id: Q5SM00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

300852:TTH RS03945
gene id: 300852:TTH_RS03945
uniprot id: Q5SK88
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family.
messages: Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway. Has weak activity with O-acetyl-L-serine, O-phospho-L-serine, L-serine, O-succinyl-L-homoserine and L-homoserine. Shows low CTT beta-lyase activity and very low CTT gamma-synthase activity.
messages: Homotetramer.
messages: Inhibited by the carbonyl reagents hydroxylamine and phenylhydrazine. Also inhibited by methionine and propargylglycine.

300852:TTH RS04155
gene id: 300852:TTH_RS04155
uniprot id: Q5SK49
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

300852:TTH RS07485
gene id: 300852:TTH_RS07485
uniprot id: Q5SI96
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS07670
gene id: 300852:TTH_RS07670
uniprot id: Q5SI59
names: Similarity
messages: Belongs to the SAICAR synthetase family.

300852:TTH RS02885
gene id: 300852:TTH_RS02885
uniprot id: P60491
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity).

300852:TTH RS01475
gene id: 300852:TTH_RS01475
uniprot id: Q5SLL3
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

300852:TTH RS09305
gene id: 300852:TTH_RS09305
uniprot id: Q5SH97
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS10675
gene id: 300852:TTH_RS10675
uniprot id: Q53W31
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

300852:TTH RS02975
gene id: 300852:TTH_RS02975
uniprot id: Q5SKS2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

300852:TTH RS06475
gene id: 300852:TTH_RS06475
uniprot id: Q5SIT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

300852:TTH RS00510
gene id: 300852:TTH_RS00510
uniprot id: Q5SM45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

300852:TTH RS10640
gene id: 300852:TTH_RS10640
uniprot id: Q5SIU5
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

300852:TTH RS00650
gene id: 300852:TTH_RS00650
uniprot id: Q5SM20
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

300852:TTH RS08040
gene id: 300852:TTH_RS08040
uniprot id: Q5SHZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

300852:TTH RS01805
gene id: 300852:TTH_RS01805
uniprot id: Q5SLF0
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

300852:TTH RS03540
gene id: 300852:TTH_RS03540
uniprot id: Q5SKG4
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS07175
gene id: 300852:TTH_RS07175
uniprot id: Q5SIF2
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

300852:TTH RS08375
gene id: 300852:TTH_RS08375
uniprot id: Q5SHS5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

300852:TTH RS08520
gene id: 300852:TTH_RS08520
uniprot id: Q5SHP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL29 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: Part of the 50S ribosomal subunit.

300852:TTH RS09685
gene id: 300852:TTH_RS09685
uniprot id: Q5SH20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

300852:TTH RS07020
gene id: 300852:TTH_RS07020
uniprot id: Q5SII3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS02985
gene id: 300852:TTH_RS02985
uniprot id: Q9LCX3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Also acts on Asp-tRNA(Asn).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

300852:TTH RS00010
gene id: 300852:TTH_RS00010
uniprot id: Q5SME1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

300852:TTH RS07230
gene id: 300852:TTH_RS07230
uniprot id: Q5SIE6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

300852:TTH RS02180
gene id: 300852:TTH_RS02180
uniprot id: P80339
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL32 family.
messages: Found on the solvent side of the large subunit.
messages: Part of the 50S ribosomal subunit.

300852:TTH RS06740
gene id: 300852:TTH_RS06740
uniprot id: Q5SIN8
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS09585
gene id: 300852:TTH_RS09585
uniprot id: Q5SH40
names: Similarity
messages: Belongs to the peptidase M29 family.

300852:TTH RS06420
gene id: 300852:TTH_RS06420
uniprot id: Q5SIU8
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

300852:TTH RS03480
gene id: 300852:TTH_RS03480
uniprot id: Q5SKH6
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

300852:TTH RS05930
gene id: 300852:TTH_RS05930
uniprot id: Q5SJ45
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

300852:TTH RS04780
gene id: 300852:TTH_RS04780
uniprot id: Q5SJR9
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

300852:TTH RS10045
gene id: 300852:TTH_RS10045
uniprot id: Q53WE6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

300852:TTH RS04520
gene id: 300852:TTH_RS04520
uniprot id: Q9LCX4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

300852:TTH RS02235
gene id: 300852:TTH_RS02235
uniprot id: Q5SL64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

300852:TTH RS08990
gene id: 300852:TTH_RS08990
uniprot id: Q5SHF7
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

300852:TTH RS08630
gene id: 300852:TTH_RS08630
uniprot id: Q5SHM4
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS09330
gene id: 300852:TTH_RS09330
uniprot id: Q5SH92
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

300852:TTH RS05970
gene id: 300852:TTH_RS05970
uniprot id: Q5SJ37
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine-5'-phosphate glycosidase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
messages: Homotrimer.

300852:TTH RS09240
gene id: 300852:TTH_RS09240
uniprot id: Q5SHB0
names: Similarity
messages: Belongs to the CinA family.

300852:TTH RS00500
gene id: 300852:TTH_RS00500
uniprot id: Q56228
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 15 different subunits, Nqo1 to Nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8 and Nqo10 to Nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9 and Nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP.

300852:TTH RS06230
gene id: 300852:TTH_RS06230
uniprot id: Q5SIY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS06690
gene id: 300852:TTH_RS06690
uniprot id: Q5SIP8
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

300852:TTH RS02865
gene id: 300852:TTH_RS02865
uniprot id: Q5SKU4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

300852:TTH RS09800
gene id: 300852:TTH_RS09800
uniprot id: Q5SH01
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS08200
gene id: 300852:TTH_RS08200
uniprot id: Q5SHW0
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activity increases by approximately two-fold in the presence of GCBP.
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily.
messages: Catalyzes the transformation of cystathionine to homocysteine. Can also use cystine or S-methylcysteine as substrate.
messages: Interacts with GCBP (TTHA1554).

300852:TTH RS05585
gene id: 300852:TTH_RS05585
uniprot id: P26996
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

300852:TTH RS05525
gene id: 300852:TTH_RS05525
uniprot id: Q5SJC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

300852:TTH RS06520
gene id: 300852:TTH_RS06520
uniprot id: Q5SIS8
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS09625
gene id: 300852:TTH_RS09625
uniprot id: Q5SH32
names: Similarity
messages: Belongs to the Nth/MutY family.

300852:TTH RS03805
gene id: 300852:TTH_RS03805
uniprot id: Q5SKB6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

300852:TTH RS10720
gene id: 300852:TTH_RS10720
uniprot id: Q53W24
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS02960
gene id: 300852:TTH_RS02960
uniprot id: Q5SKS5
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS07015
gene id: 300852:TTH_RS07015
uniprot id: Q5SII4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

300852:TTH RS02050
gene id: 300852:TTH_RS02050
uniprot id: Q5SLA1
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

300852:TTH RS04075
gene id: 300852:TTH_RS04075
uniprot id: Q5SMG6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

300852:TTH RS05640
gene id: 300852:TTH_RS05640
uniprot id: Q5SJA6
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS06920
gene id: 300852:TTH_RS06920
uniprot id: Q5SIK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

300852:TTH RS05710
gene id: 300852:TTH_RS05710
uniprot id: Q5SJ91
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

300852:TTH RS05705
gene id: 300852:TTH_RS05705
uniprot id: Q5SJ92
names: Similarity
messages: Belongs to the asp23 family.

300852:TTH RS03650
gene id: 300852:TTH_RS03650
uniprot id: Q56425
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

300852:TTH RS05015
gene id: 300852:TTH_RS05015
uniprot id: Q5SJM1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

300852:TTH RS10265
gene id: 300852:TTH_RS10265
uniprot id: Q53WA7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

300852:TTH RS07895
gene id: 300852:TTH_RS07895
uniprot id: Q5SI21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

300852:TTH RS03420
gene id: 300852:TTH_RS03420
uniprot id: Q84BQ9
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Contains an N-terminal substrate recognition domain and a C-terminal methyltransferase domain, connected by a flexible linker.
messages: Cytoplasm
messages: Methylates ribosomal protein L11 (PubMed:15317787). Preferentially recognizes free L11 before its incorporation into 50S subunits (PubMed:15317787). This function is dispensable for growth and thermostability (PubMed:15317787).
messages: Mutant contains unmethylated protein L11 (PubMed:15317787). Null mutant is perfectly viable (PubMed:15317787).

300852:TTH RS10325
gene id: 300852:TTH_RS10325
uniprot id: Q53W95
names: Similarity
messages: Belongs to the alkaline phosphatase family.

300852:TTH RS05940
gene id: 300852:TTH_RS05940
uniprot id: Q5SJ43
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

300852:TTH RS01000
gene id: 300852:TTH_RS01000
uniprot id: Q5SLV2
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

300852:TTH RS10010
gene id: 300852:TTH_RS10010
uniprot id: Q5SGV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

300852:TTH RS04270
gene id: 300852:TTH_RS04270
uniprot id: Q5SK25
names: Similarity
messages: Belongs to the Skp family.

300852:TTH RS10410
gene id: 300852:TTH_RS10410
uniprot id: Q5SIU5
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

300852:TTH RS03950
gene id: 300852:TTH_RS03950
uniprot id: Q5SK87
names: Similarity
messages: Belongs to the SufE family.

300852:TTH RS04435
gene id: 300852:TTH_RS04435
uniprot id: P43891
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

300852:TTH RS10660
gene id: 300852:TTH_RS10660
uniprot id: Q53W34
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

300852:TTH RS09990
gene id: 300852:TTH_RS09990
uniprot id: Q5SGW2
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS04890
gene id: 300852:TTH_RS04890
uniprot id: Q5SJP6
names: Similarity
messages: Belongs to the extradiol ring-cleavage dioxygenase family.

300852:TTH RS03985
gene id: 300852:TTH_RS03985
uniprot id: Q5SK80
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

300852:TTH RS01090
gene id: 300852:TTH_RS01090
uniprot id: Q8VVE3
names: Caution
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Note that in PubMed:11154066 it was found that the N-terminus is blocked, whereas the mass determined in PubMed:16287167 suggests that the initiator methionine is removed. No extra mass for a blocking group was found.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which 3 L12 dimers bind in a sequential fashion.
messages: The N-terminus is blocked.

300852:TTH RS06160
gene id: 300852:TTH_RS06160
uniprot id: Q5SJ01
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

300852:TTH RS10485
gene id: 300852:TTH_RS10485
uniprot id: Q53W63
names: Function
names: Subunit
messages: Activates transcription. Positively regulates PcrtB promoter upstream of the crtB operon in a cAMP-independent manner. Regulated genes include genes encoding DNA photolyase, phytoene synthase and cytochrome P450 monooxygenase, which are involved in carotenoid biosynthesis. Positively regulates the light-inducible gene cluster in the megaplasmid in a cAMP-independent manner.
messages: Homodimer.

300852:TTH RS00495
gene id: 300852:TTH_RS00495
uniprot id: Q56227
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 5 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 15 different subunits, Nqo1 to Nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8 and Nqo10 to Nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9 and Nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP.

300852:TTH RS08700
gene id: 300852:TTH_RS08700
uniprot id: Q5SHL3
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

300852:TTH RS10505
gene id: 300852:TTH_RS10505
uniprot id: Q53W59
names: Similarity
messages: Belongs to the cytochrome P450 family.

300852:TTH RS08385
gene id: 300852:TTH_RS08385
uniprot id: Q5SHS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

300852:TTH RS06240
gene id: 300852:TTH_RS06240
uniprot id: Q9ZND5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

300852:TTH RS09410
gene id: 300852:TTH_RS09410
uniprot id: Q5SH75
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS05360
gene id: 300852:TTH_RS05360
uniprot id: Q5SJF5
names: Similarity
messages: Belongs to the IMPACT family.

300852:TTH RS08940
gene id: 300852:TTH_RS08940
uniprot id: Q5SHG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

300852:TTH RS01395
gene id: 300852:TTH_RS01395
uniprot id: Q5SLN0
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS01610
gene id: 300852:TTH_RS01610
uniprot id: Q5SLI7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

300852:TTH RS02590
gene id: 300852:TTH_RS02590
uniprot id: Q5SKZ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I Nqo15 family.
messages: Cell membrane
messages: Has a similar fold to the mitochondrial iron chaperone frataxin.
messages: NDH-1 is composed of 15 different subunits, Nqo1 to Nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8 and Nqo10 to Nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9 and Nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers. Nqo15 is bound to the side of the complex near the N-terminus of Nqo3, where it interacts with subunits Nqo3, Nqo2, Nqo1, Nqo9 and Nqo4.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP. The Nqo15 subunit has probably a role in complex stabilization, and may be also involved in the storage of iron for iron-sulfur cluster regeneration in the complex.

300852:TTH RS01295
gene id: 300852:TTH_RS01295
uniprot id: Q5SLP6
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. The stalk extends beyond the surface of the 70S ribosome and is preferentially stabilized in 70S versus 50S crystals.
messages: In the 70S ribosome is in a position where it could interact transiently with the A site tRNA during translation.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which 3 L12 dimers bind in a sequential fashion forming a heptameric L10(L12)2(L12)2(L12)2 complex. Contacts one of the L7 dimers. Interacts with RF2 (release factor 2) (PubMed:18988853).
messages: The protein probably contains twelve methyl groups; at least one lysine residue (Lys-3) is known to be trimethylated. Methylation of the protein is not required for function.

300852:TTH RS05545
gene id: 300852:TTH_RS05545
uniprot id: Q5SJC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

300852:TTH RS11260
gene id: 300852:TTH_RS11260
uniprot id: Q53VT5
names: Similarity
messages: Belongs to the extradiol ring-cleavage dioxygenase family.

300852:TTH RS00845
gene id: 300852:TTH_RS00845
uniprot id: Q5SLY2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS09715
gene id: 300852:TTH_RS09715
uniprot id: Q5SH14
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

300852:TTH RS08135
gene id: 300852:TTH_RS08135
uniprot id: Q5SHX3
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

300852:TTH RS05355
gene id: 300852:TTH_RS05355
uniprot id: Q5SJF6
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

300852:TTH RS07595
gene id: 300852:TTH_RS07595
uniprot id: Q5SI74
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

300852:TTH RS02280
gene id: 300852:TTH_RS02280
uniprot id: P27000
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: In the absence of bound tRNA, ATP is bound in a non-productive mode, and the enzyme cannot activate amino acids.
messages: Monomer.

300852:TTH RS01600
gene id: 300852:TTH_RS01600
uniprot id: Q5SLI9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

300852:TTH RS04460
gene id: 300852:TTH_RS04460
uniprot id: Q5SJY9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

300852:TTH RS01860
gene id: 300852:TTH_RS01860
uniprot id: Q5SLE0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

300852:TTH RS03970
gene id: 300852:TTH_RS03970
uniprot id: Q5SK83
names: Similarity
messages: Belongs to the peptidase S58 family.

300852:TTH RS01005
gene id: 300852:TTH_RS01005
uniprot id: Q5SLV1
names: Similarity
messages: Belongs to the universal stress protein A family.

300852:TTH RS03975
gene id: 300852:TTH_RS03975
uniprot id: Q5SK82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 7 family.
messages: Homodimer. The complex comprises the extracytoplasmic solute receptor protein TTHA0766, and the two putative transmembrane proteins TTHA0767 and TTHA0768.
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system involved in the uptake of lactate. This protein specifically binds L-lactate.
messages: Periplasm

300852:TTH RS00740
gene id: 300852:TTH_RS00740
uniprot id: Q5SM03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

300852:TTH RS02595
gene id: 300852:TTH_RS02595
uniprot id: Q5SKZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

300852:TTH RS00770
gene id: 300852:TTH_RS00770
uniprot id: Q5SLZ7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

300852:TTH RS02175
gene id: 300852:TTH_RS02175
uniprot id: Q5SL76
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

300852:TTH RS01340
gene id: 300852:TTH_RS01340
uniprot id: Q5SLP1
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family.
messages: Binds 2 Zn(2+) ions.
messages: Cytoplasm
messages: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro).
messages: Inhibited by cadmium, cobalt, manganese, magnesium, calcium and nickel ions.
messages: Monomer.

300852:TTH RS04540
gene id: 300852:TTH_RS04540
uniprot id: Q5SJX2
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS09590
gene id: 300852:TTH_RS09590
uniprot id: Q5SH39
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

300852:TTH RS10990
gene id: 300852:TTH_RS10990
uniprot id: Q53WG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

300852:TTH RS00960
gene id: 300852:TTH_RS00960
uniprot id: Q5SLW0
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

300852:TTH RS07415
gene id: 300852:TTH_RS07415
uniprot id: P60488
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

300852:TTH RS09030
gene id: 300852:TTH_RS09030
uniprot id: Q5SHE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

300852:TTH RS02940
gene id: 300852:TTH_RS02940
uniprot id: Q5SKS9
names: Subcellular Location Annotation
messages: Cytoplasm

300852:TTH RS02955
gene id: 300852:TTH_RS02955
uniprot id: Q5SKS6
names: Similarity
messages: Belongs to the acylphosphatase family.

300852:TTH RS01025
gene id: 300852:TTH_RS01025
uniprot id: Q5SLU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 7 family.
messages: Homodimer.
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: Periplasm

300852:TTH RS06040
gene id: 300852:TTH_RS06040
uniprot id: Q5SJ25
names: Similarity
messages: Belongs to the MreC family.

300852:TTH RS06175
gene id: 300852:TTH_RS06175
uniprot id: Q5SIZ7
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Cell outer membrane
messages: Membrane
messages: Periplasm

300852:TTH RS05920
gene id: 300852:TTH_RS05920
uniprot id: Q5SJ47
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RecJ family.
messages: Monomer. Intact protein binds ss- but not dsDNA.
messages: Requires a divalent cation; Mg(2+) > Mn(2+) > Co(2+). Structures with 1 Mg(2+), or 1 or 2 Mn(2+) were determined; the authors conclude 2 metal ions are required for activity.
messages: Single-stranded-DNA-specific exonuclease acting in a 5' to 3' direction; has no detectable activity on ssRNA.

300852:TTH RS09840
gene id: 300852:TTH_RS09840
uniprot id: Q5SGZ3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

300852:TTH RS04745
gene id: 300852:TTH_RS04745
uniprot id: Q5SJS6
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

300852:TTH RS09950
gene id: 300852:TTH_RS09950
uniprot id: Q5SGX1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

300852:TTH RS06270
gene id: 300852:TTH_RS06270
uniprot id: Q5SIY0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

300852:TTH RS02695
gene id: 300852:TTH_RS02695
uniprot id: Q5SKX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

300852:TTH RS03060
gene id: 300852:TTH_RS03060
uniprot id: Q5SKQ4
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS06390
gene id: 300852:TTH_RS06390
uniprot id: Q5SIV4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

300852:TTH RS06020
gene id: 300852:TTH_RS06020
uniprot id: Q5SJ29
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

300852:TTH RS06465
gene id: 300852:TTH_RS06465
uniprot id: P74902
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

300852:TTH RS03490
gene id: 300852:TTH_RS03490
uniprot id: Q5SKH4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

300852:TTH RS03215
gene id: 300852:TTH_RS03215
uniprot id: Q5SKM6
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

300852:TTH RS00800
gene id: 300852:TTH_RS00800
uniprot id: Q5SLZ1
names: Similarity
messages: Belongs to the AOR/FOR family.

300852:TTH RS01865
gene id: 300852:TTH_RS01865
uniprot id: Q5SLD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

300852:TTH RS09470
gene id: 300852:TTH_RS09470
uniprot id: Q5SIU5
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

300852:TTH RS02745
gene id: 300852:TTH_RS02745
uniprot id: Q5SKW6
names: Similarity
messages: Belongs to the ribF family.

300852:TTH RS05575
gene id: 300852:TTH_RS05575
uniprot id: Q5SJB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

300852:TTH RS02820
gene id: 300852:TTH_RS02820
uniprot id: Q5SKV2
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

300852:TTH RS06345
gene id: 300852:TTH_RS06345
uniprot id: Q5SIW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
messages: Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved. Monomer and homodimer.

300852:TTH RS05700
gene id: 300852:TTH_RS05700
uniprot id: Q5SJ93
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

300852:TTH RS03720
gene id: 300852:TTH_RS03720
uniprot id: Q5SKC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

300852:TTH RS00285
gene id: 300852:TTH_RS00285
uniprot id: Q5SM89
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS01310
gene id: 300852:TTH_RS01310
uniprot id: P35871
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL33 family.
messages: Contacts the E site tRNA.
messages: Found on the solvent side of the large subunit.
messages: Part of the 50S ribosomal subunit.

300852:TTH RS06600
gene id: 300852:TTH_RS06600
uniprot id: Q5SIR1
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS05765
gene id: 300852:TTH_RS05765
uniprot id: Q5SJ79
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 2 heme groups.
messages: Binds a copper B center.
messages: Cell membrane

300852:TTH RS04440
gene id: 300852:TTH_RS04440
uniprot id: P43895
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm
messages: Heterotetramer composed of two EF-Ts.EF-Tu dimer complexes.

300852:TTH RS03285
gene id: 300852:TTH_RS03285
uniprot id: Q5SKL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

300852:TTH RS06450
gene id: 300852:TTH_RS06450
uniprot id: Q56404
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

300852:TTH RS03760
gene id: 300852:TTH_RS03760
uniprot id: Q5SKB9
names: Similarity
messages: Belongs to the peptidase S8 family.

300852:TTH RS04595
gene id: 300852:TTH_RS04595
uniprot id: Q5SJW1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

300852:TTH RS03880
gene id: 300852:TTH_RS03880
uniprot id: Q5SKA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

300852:TTH RS08320
gene id: 300852:TTH_RS08320
uniprot id: Q5SHT6
names: Similarity
messages: Belongs to the LOG family.

300852:TTH RS06765
gene id: 300852:TTH_RS06765
uniprot id: Q5SIN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

300852:TTH RS00640
gene id: 300852:TTH_RS00640
uniprot id: Q5SM22
names: Similarity
messages: Belongs to the DprA/Smf family.

300852:TTH RS04060
gene id: 300852:TTH_RS04060
uniprot id: Q5SK65
names: Function
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Probably regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. In contrast to pyr attenuation in Bacillus, PyrR from Thermus could act as a translational repressor: the binding of PyrR at its proposed recognition site in the transcript would prevent initiation of translation of the leader peptide, resulting in terminator formation and reduced expression of downstream genes (By similarity). Also displays uracil phosphoribosyltransferase activity (By similarity).

300852:TTH RS01085
gene id: 300852:TTH_RS01085
uniprot id: Q5SLT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

300852:TTH RS01375
gene id: 300852:TTH_RS01375
uniprot id: Q5SLN4
names: Function
names: Similarity
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.

300852:TTH RS08285
gene id: 300852:TTH_RS08285
uniprot id: Q5SHU3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS10615
gene id: 300852:TTH_RS10615
uniprot id: Q53W42
names: Similarity
messages: Belongs to the ParB family.

300852:TTH RS09440
gene id: 300852:TTH_RS09440
uniprot id: Q5SH69
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

300852:TTH RS06075
gene id: 300852:TTH_RS06075
uniprot id: Q5SJ18
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

300852:TTH RS08525
gene id: 300852:TTH_RS08525
uniprot id: P60489
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds directly to 23S rRNA. Interacts with the A site tRNA.

300852:TTH RS06305
gene id: 300852:TTH_RS06305
uniprot id: Q5SIX2
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

300852:TTH RS09850
gene id: 300852:TTH_RS09850
uniprot id: Q5SGZ1
names: Similarity
messages: Belongs to the Nudix hydrolase family.

300852:TTH RS11095
gene id: 300852:TTH_RS11095
uniprot id: Q53VW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

300852:TTH RS01460
gene id: 300852:TTH_RS01460
uniprot id: Q5SLL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

300852:TTH RS01075
gene id: 300852:TTH_RS01075
uniprot id: Q5SLT7
names: Similarity
messages: Belongs to the AlaDH/PNT family.

300852:TTH RS03220
gene id: 300852:TTH_RS03220
uniprot id: Q5SKM5
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

300852:TTH RS08775
gene id: 300852:TTH_RS08775
uniprot id: Q5SHJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

300852:TTH RS11205
gene id: 300852:TTH_RS11205
uniprot id: Q53VT9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

300852:TTH RS09015
gene id: 300852:TTH_RS09015
uniprot id: Q5SHF2
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

300852:TTH RS05570
gene id: 300852:TTH_RS05570
uniprot id: Q5SJC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

300852:TTH RS05105
gene id: 300852:TTH_RS05105
uniprot id: Q5SJK3
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

300852:TTH RS01315
gene id: 300852:TTH_RS01315
uniprot id: P60339
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: Phosphorylated on a threonine.
messages: Protects glycyl-tRNA(Gly) from hydrolysis by E.coli D-aminoacyl-tRNA deacylase (dtd) (PubMed:27224426).
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

300852:TTH RS09220
gene id: 300852:TTH_RS09220
uniprot id: Q5SHB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS05910
gene id: 300852:TTH_RS05910
uniprot id: Q5SJ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

300852:TTH RS07280
gene id: 300852:TTH_RS07280
uniprot id: Q5SID6
names: Similarity
messages: Belongs to the ComB family.

300852:TTH RS01250
gene id: 300852:TTH_RS01250
uniprot id: Q5SLQ4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

300852:TTH RS07660
gene id: 300852:TTH_RS07660
uniprot id: Q5SI61
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

300852:TTH RS07070
gene id: 300852:TTH_RS07070
uniprot id: Q5SIH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bTHX family.
messages: Binds at the top of the head of the 30S subunit. It stabilizes a number of different RNA elements and thus is important for subunit structure.
messages: Part of the 30S ribosomal subunit.

300852:TTH RS07755
gene id: 300852:TTH_RS07755
uniprot id: Q5SI48
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

300852:TTH RS07715
gene id: 300852:TTH_RS07715
uniprot id: Q5SI56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS06110
gene id: 300852:TTH_RS06110
uniprot id: Q5SJ11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

300852:TTH RS09965
gene id: 300852:TTH_RS09965
uniprot id: Q5SGW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

300852:TTH RS03800
gene id: 300852:TTH_RS03800
uniprot id: Q5SKB7
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

300852:TTH RS00780
gene id: 300852:TTH_RS00780
uniprot id: Q5SLZ5
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

300852:TTH RS03115
gene id: 300852:TTH_RS03115
uniprot id: Q5SKP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

300852:TTH RS10540
gene id: 300852:TTH_RS10540
uniprot id: Q53W52
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS04255
gene id: 300852:TTH_RS04255
uniprot id: Q5SK28
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Cells lacking both speB and speE genes show defective growth at 70 degrees Celsius and significantly defective growth at 78 degrees Celsius. They accumulate agmatine and N1-aminopropylagmatine.
messages: Cytoplasm
messages: Homotetramer.
messages: In T.thermophilus, the biosynthetic pathways of spermidine operates via N1-aminopropylagmatine without the production of putrescine.
messages: Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high-temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to agmatine to yield N1-aminopropylagmatine. An efficient aminopropyltransferase activity has been also observed with norspermidine which produces thermine, and spermidine which produces spermine and thermospermine. The aminopropyl activity with homospermidine, mitsubishine, thermine, 1,3-diaminopropane, putrescine (1,4-diaminobutane), spermine and caldopentamine are very low. The reaction involves a nucleophilic attack on the C-3 methylene of the propylamine moiety adjacent to the positively charged sulfur of decarboxy-AdoMet.

300852:TTH RS09845
gene id: 300852:TTH_RS09845
uniprot id: Q5SGZ2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

300852:TTH RS03025
gene id: 300852:TTH_RS03025
uniprot id: Q5SKR1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

300852:TTH RS02150
gene id: 300852:TTH_RS02150
uniprot id: Q5SL81
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

300852:TTH RS03665
gene id: 300852:TTH_RS03665
uniprot id: Q5SKD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

300852:TTH RS05005
gene id: 300852:TTH_RS05005
uniprot id: Q5SJM3
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

300852:TTH RS07980
gene id: 300852:TTH_RS07980
uniprot id: Q5SI04
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

300852:TTH RS02245
gene id: 300852:TTH_RS02245
uniprot id: Q5SL62
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

300852:TTH RS02980
gene id: 300852:TTH_RS02980
uniprot id: Q5SKS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Monomer.

300852:TTH RS06080
gene id: 300852:TTH_RS06080
uniprot id: Q5SJ17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

300852:TTH RS02680
gene id: 300852:TTH_RS02680
uniprot id: Q5SKX9
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

300852:TTH RS09945
gene id: 300852:TTH_RS09945
uniprot id: Q5SGX2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

300852:TTH RS03915
gene id: 300852:TTH_RS03915
uniprot id: Q5SK94
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS00680
gene id: 300852:TTH_RS00680
uniprot id: Q5SM14
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

300852:TTH RS09080
gene id: 300852:TTH_RS09080
uniprot id: Q5SHE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

300852:TTH RS06435
gene id: 300852:TTH_RS06435
uniprot id: Q5SIU5
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

300852:TTH RS05530
gene id: 300852:TTH_RS05530
uniprot id: Q5SJC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

300852:TTH RS01360
gene id: 300852:TTH_RS01360
uniprot id: Q5SLN7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

300852:TTH RS10560
gene id: 300852:TTH_RS10560
uniprot id: Q53WF7
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

300852:TTH RS04840
gene id: 300852:TTH_RS04840
uniprot id: Q5SJQ6
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

300852:TTH RS00620
gene id: 300852:TTH_RS00620
uniprot id: Q5SM25
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NrnA oligoribonuclease family.
messages: Bifunctional enzyme which has both oligoribonuclease and pAp-phosphatase activities. Degrades short RNA and DNA oligonucleotides with a length of up to 33 nucleotides, although the enzyme is most active on shorter substrates, in a 5' to 3' direction. Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP, has very low activity on cAMP and cGMP.
messages: Oligomeric.
messages: Reduced growth in minimal medium, possibly also affected in cysteine assimilation.
messages: Requires a divalent cation; Co(2+) > Mn(2+) >Zn(2+) > Mg(2+).

300852:TTH RS09655
gene id: 300852:TTH_RS09655
uniprot id: Q5SH26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Catalyzes the NADPH-dependent reduction of [LysW]-aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde.
messages: Cytoplasm

300852:TTH RS09040
gene id: 300852:TTH_RS09040
uniprot id: P60492
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Contacts protein L20 (By similarity). Part of the 50S ribosomal subunit.
messages: This protein binds to 23S rRNA in the presence of protein L20 (By similarity). Found on the solvent side of the large subunit.

300852:TTH RS08905
gene id: 300852:TTH_RS08905
uniprot id: Q5SHH3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine.
messages: Cytoplasm

300852:TTH RS10975
gene id: 300852:TTH_RS10975
uniprot id: Q53WG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

300852:TTH RS00090
gene id: 300852:TTH_RS00090
uniprot id: Q5SMC8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

300852:TTH RS08315
gene id: 300852:TTH_RS08315
uniprot id: Q5SHT7
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

300852:TTH RS00930
gene id: 300852:TTH_RS00930
uniprot id: P03942
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

300852:TTH RS10300
gene id: 300852:TTH_RS10300
uniprot id: Q53WA0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

300852:TTH RS10535
gene id: 300852:TTH_RS10535
uniprot id: Q53W53
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

300852:TTH RS05540
gene id: 300852:TTH_RS05540
uniprot id: Q5SJC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

300852:TTH RS09975
gene id: 300852:TTH_RS09975
uniprot id: P38576
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

300852:TTH RS02105
gene id: 300852:TTH_RS02105
uniprot id: Q5SL90
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS07360
gene id: 300852:TTH_RS07360
uniprot id: Q5SIC0
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

300852:TTH RS01915
gene id: 300852:TTH_RS01915
uniprot id: Q9LCX2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

300852:TTH RS08245
gene id: 300852:TTH_RS08245
uniprot id: Q5SHV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

300852:TTH RS09090
gene id: 300852:TTH_RS09090
uniprot id: Q8RQP5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

300852:TTH RS08095
gene id: 300852:TTH_RS08095
uniprot id: Q5SHY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

300852:TTH RS08565
gene id: 300852:TTH_RS08565
uniprot id: Q5SHN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes (By similarity). Part of the top of the 30S subunit head.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S3 and S14. Also contacts protein S9.

300852:TTH RS06195
gene id: 300852:TTH_RS06195
uniprot id: Q5SIZ3
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Periplasm

300852:TTH RS01435
gene id: 300852:TTH_RS01435
uniprot id: Q5SLM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

300852:TTH RS04685
gene id: 300852:TTH_RS04685
uniprot id: Q5SJU9
names: Caution
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

300852:TTH RS00180
gene id: 300852:TTH_RS00180
uniprot id: Q5SMB0
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

300852:TTH RS08430
gene id: 300852:TTH_RS08430
uniprot id: P80376
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the upper part of the platform of the 30S subunit, where it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome, where it interacts both with the Shine-Dalgarno helix and mRNA.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to the C-terminus of IF-3; however exactly how IF-3 interacts with the 30S subunit is unclear. May contact the C-terminus of Era.

300852:TTH RS09230
gene id: 300852:TTH_RS09230
uniprot id: Q5SHB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

300852:TTH RS09285
gene id: 300852:TTH_RS09285
uniprot id: Q5SHA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF nuclease family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

300852:TTH RS02435
gene id: 300852:TTH_RS02435
uniprot id: Q5SL24
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

300852:TTH RS03390
gene id: 300852:TTH_RS03390
uniprot id: Q5SKJ3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

300852:TTH RS02165
gene id: 300852:TTH_RS02165
uniprot id: Q5SL78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

300852:TTH RS01910
gene id: 300852:TTH_RS01910
uniprot id: Q5SLC8
names: Similarity
messages: Belongs to the GSP E family.

300852:TTH RS08550
gene id: 300852:TTH_RS08550
uniprot id: Q5SHP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Contacts protein L29, and trigger factor when it is bound to the ribosome (By similarity). Part of the 50S ribosomal subunit.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.

300852:TTH RS08555
gene id: 300852:TTH_RS08555
uniprot id: Q5SHN9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).
messages: Part of the 50S ribosomal subunit.
messages: The N-terminus is blocked.
messages: This protein can be incorporated into E.coli ribosomes in vivo, which resulted in decreased peptidyltransferase (Ptase) activity of the hybrid ribosomes. The hybrid 50S subunits associate less well with 30S subunits to form the ribosome.

300852:TTH RS02310
gene id: 300852:TTH_RS02310
uniprot id: Q5SL49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

300852:TTH RS03590
gene id: 300852:TTH_RS03590
uniprot id: Q5SKF3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

300852:TTH RS11125
gene id: 300852:TTH_RS11125
uniprot id: Q53VV4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

300852:TTH RS07410
gene id: 300852:TTH_RS07410
uniprot id: P80374
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS9 family.
messages: Part of the 30S ribosomal subunit. Contacts proteins S7 and S10.
messages: Part of the top of the head of the 30S subunit. The C-terminal region penetrates the head emerging in the P-site where it contacts tRNA.

300852:TTH RS07310
gene id: 300852:TTH_RS07310
uniprot id: Q7SIB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

300852:TTH RS10585
gene id: 300852:TTH_RS10585
uniprot id: Q53W47
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Periplasm

300852:TTH RS03560
gene id: 300852:TTH_RS03560
uniprot id: Q5SKG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

300852:TTH RS05995
gene id: 300852:TTH_RS05995
uniprot id: Q5SJ32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS03165
gene id: 300852:TTH_RS03165
uniprot id: Q5SKN4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Contains a large catalytic C-terminal domain that binds S-adenosyl-L-methionine and a smaller N-terminal domain that may play a role in tRNA recognition. Domains are connected by a linker region.
messages: Homotetramer composed of a dimer of dimers.

300852:TTH RS01120
gene id: 300852:TTH_RS01120
uniprot id: Q5SLS8
names: Similarity
messages: Belongs to the asp23 family.

300852:TTH RS07540
gene id: 300852:TTH_RS07540
uniprot id: Q56237
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Cytoplasm
messages: Does not influence ATP binding or hydrolysis nor ADP release. Exerts influence on the interaction of DnaK with substrates; in the presence of DafA, DnaJ inhibits substrate binding, and substrate already bound to DnaK is displaced by DnaJ and DafA.
messages: Forms a heterononamer with DnaJ and DafA in the resting state. Three copies of each protein are present in the complex.

300852:TTH RS09010
gene id: 300852:TTH_RS09010
uniprot id: Q5SHF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

300852:TTH RS02485
gene id: 300852:TTH_RS02485
uniprot id: Q5SL14
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

300852:TTH RS10050
gene id: 300852:TTH_RS10050
uniprot id: Q53WE5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

300852:TTH RS06395
gene id: 300852:TTH_RS06395
uniprot id: Q5SIV3
names: Similarity
messages: Belongs to the disproportionating enzyme family.

300852:TTH RS06155
gene id: 300852:TTH_RS06155
uniprot id: Q5SJ02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

300852:TTH RS01290
gene id: 300852:TTH_RS01290
uniprot id: Q5SLP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Directly binds to 23S rRNA. Forms what is known as the L1 stalk, which protrudes beyond the 70S ribosome surface. The stalk is preferentially stabilized in 70S versus 50S crystals. Interacts with the E site tRNA, blocking the exit path. This blockage implies that this section of the ribosome must be able to move to release the deacetylated tRNA.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

300852:TTH RS09295
gene id: 300852:TTH_RS09295
uniprot id: P74941
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

300852:TTH RS01825
gene id: 300852:TTH_RS01825
uniprot id: Q5SLE6
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

300852:TTH RS08340
gene id: 300852:TTH_RS08340
uniprot id: Q5SHT2
names: Similarity
messages: Belongs to the HepT RNase toxin family.

300852:TTH RS05580
gene id: 300852:TTH_RS05580
uniprot id: Q5SJB8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

300852:TTH RS07260
gene id: 300852:TTH_RS07260
uniprot id: Q5SIE0
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

300852:TTH RS10420
gene id: 300852:TTH_RS10420
uniprot id: Q53W76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

300852:TTH RS07265
gene id: 300852:TTH_RS07265
uniprot id: Q5SID9
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

300852:TTH RS09960
gene id: 300852:TTH_RS09960
uniprot id: P21777
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides (By similarity). Allosterically inhibited by phosphoenolpyruvate which induces the dissociation of the active tetramer into an inactive two-subunit forms.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.

300852:TTH RS09720
gene id: 300852:TTH_RS09720
uniprot id: Q5SH13
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS03775
gene id: 300852:TTH_RS03775
uniprot id: Q5SMF6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Also able to catalyze the hydration of cis-homoaconitate to yield (R)-homocitrate, but with a lower efficiency (PubMed:23106124). Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein (By similarity).
messages: Monomer.

300852:TTH RS03295
gene id: 300852:TTH_RS03295
uniprot id: Q5SKL3
names: Similarity
messages: Belongs to the ClpX chaperone family. HslU subfamily.

300852:TTH RS08810
gene id: 300852:TTH_RS08810
uniprot id: Q5SHJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

300852:TTH RS07110
gene id: 300852:TTH_RS07110
uniprot id: Q5SIG5
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

300852:TTH RS02870
gene id: 300852:TTH_RS02870
uniprot id: Q5SKU3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

300852:TTH RS02125
gene id: 300852:TTH_RS02125
uniprot id: Q5SL86
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

300852:TTH RS10385
gene id: 300852:TTH_RS10385
uniprot id: Q53W83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Homohexamer; trimer of dimers.
messages: Involved in the degradation of glucose via the semi-phosphorylative Entner-Doudoroff pathway. Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG).

300852:TTH RS06735
gene id: 300852:TTH_RS06735
uniprot id: Q5SIN9
names: Similarity
messages: Belongs to the leucine-binding protein family.

300852:TTH RS05865
gene id: 300852:TTH_RS05865
uniprot id: Q5SJ58
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family.
messages: Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway. Has weak activity with O-acetyl-L-serine, O-phospho-L-serine, L-serine, O-succinyl-L-homoserine and L-homoserine. Shows a very low CTT gamma-synthase activity.
messages: Homotetramer.
messages: Inhibited by the carbonyl reagents hydroxylamine and phenylhydrazine. Also inhibited by methionine and propargylglycine.

300852:TTH RS08545
gene id: 300852:TTH_RS08545
uniprot id: P60405
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial (By similarity). Makes several contacts with the 16S rRNA (forming bridge B7b) in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome, contacting the 16S rRNA. May also make transient contacts with protein S6 during translation in the 70S ribosome.

300852:TTH RS00335
gene id: 300852:TTH_RS00335
uniprot id: Q5SM79
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS00565
gene id: 300852:TTH_RS00565
uniprot id: Q5SM35
names: Similarity
messages: Belongs to the transketolase family.

300852:TTH RS09675
gene id: 300852:TTH_RS09675
uniprot id: Q5SH22
names: Function
names: Miscellaneous
names: PTM
messages: Carrier protein that bears the covalently bound substrates for lysine biosynthesis; the bound alpha-aminoadipate (AAA) is sequentially converted to L-lysine.
messages: Formation of an isopeptide bond between the gamma-carboxyl group of the C-terminal glutamate and the amino group of alpha-aminoadipate (AAA) is catalyzed by LysX. The bound AAA is then converted to L-lysine in a series of reactions catalyzed by LysZ, LysY and LysJ. Release of the product L-lysine is catalyzed by LysK (PubMed:19620981).
messages: The purified protein is red, and its absorption spectrum suggests that it binds iron ions, possibly via the predicted zinc finger domain (PubMed:19620981). In contrast, the ortholog from Sulfolobus clearly binds zinc ions via its zinc finger domain, as shown by X-ray crystallography.

300852:TTH RS04605
gene id: 300852:TTH_RS04605
uniprot id: Q5SJV9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

300852:TTH RS01520
gene id: 300852:TTH_RS01520
uniprot id: Q5SLK5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

300852:TTH RS00685
gene id: 300852:TTH_RS00685
uniprot id: Q5SM13
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS01960
gene id: 300852:TTH_RS01960
uniprot id: Q5SLC1
names: Similarity
messages: Belongs to the UPF0102 family.

300852:TTH RS00645
gene id: 300852:TTH_RS00645
uniprot id: Q5SM21
names: Similarity
messages: Belongs to the manganese catalase family.

300852:TTH RS07055
gene id: 300852:TTH_RS07055
uniprot id: Q5SIH6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

300852:TTH RS06815
gene id: 300852:TTH_RS06815
uniprot id: Q5SIM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

300852:TTH RS07840
gene id: 300852:TTH_RS07840
uniprot id: Q5SI32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

300852:TTH RS02160
gene id: 300852:TTH_RS02160
uniprot id: Q5SL79
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

300852:TTH RS00830
gene id: 300852:TTH_RS00830
uniprot id: Q5SLY5
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

300852:TTH RS10500
gene id: 300852:TTH_RS10500
uniprot id: P61497
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.
messages: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation (By similarity).
messages: Monomer.

300852:TTH RS04995
gene id: 300852:TTH_RS04995
uniprot id: Q5SJM5
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

300852:TTH RS03850
gene id: 300852:TTH_RS03850
uniprot id: Q5SKA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

300852:TTH RS05945
gene id: 300852:TTH_RS05945
uniprot id: Q5SJ42
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

300852:TTH RS09160
gene id: 300852:TTH_RS09160
uniprot id: Q5SHC6
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

300852:TTH RS02740
gene id: 300852:TTH_RS02740
uniprot id: Q5SKW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

300852:TTH RS03645
gene id: 300852:TTH_RS03645
uniprot id: P48514
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

300852:TTH RS04615
gene id: 300852:TTH_RS04615
uniprot id: Q5SJV7
names: Similarity
messages: Belongs to the universal stress protein A family.

300852:TTH RS03685
gene id: 300852:TTH_RS03685
uniprot id: P54263
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS04340
gene id: 300852:TTH_RS04340
uniprot id: Q5SK12
names: Similarity
messages: Belongs to the Lgt family.

300852:TTH RS02380
gene id: 300852:TTH_RS02380
uniprot id: Q5SL35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

300852:TTH RS08460
gene id: 300852:TTH_RS08460
uniprot id: Q5SHQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

300852:TTH RS02545
gene id: 300852:TTH_RS02545
uniprot id: Q5SL04
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

300852:TTH RS05270
gene id: 300852:TTH_RS05270
uniprot id: Q5SJH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS16 family.
messages: Binds to the lower part of the body of the 30S subunit, where it stabilizes two of its domains.
messages: Part of the 30S ribosomal subunit.

300852:TTH RS03350
gene id: 300852:TTH_RS03350
uniprot id: Q5SKK2
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS04730
gene id: 300852:TTH_RS04730
uniprot id: Q5SJS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer. All subunits in the hexamer bind substrate. Is in equilibrium between two trimers and a hexamer, and the trimer may be a physiologically important form in T.thermophilus.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

300852:TTH RS01430
gene id: 300852:TTH_RS01430
uniprot id: Q5SLM3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues, but not Pro. Has lower activity with substrates ending with Gly or Glu.
messages: Homodimer.

300852:TTH RS02930
gene id: 300852:TTH_RS02930
uniprot id: Q5SKT1
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

300852:TTH RS02710
gene id: 300852:TTH_RS02710
uniprot id: Q5SKX3
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

300852:TTH RS07330
gene id: 300852:TTH_RS07330
uniprot id: Q5SIC6
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

300852:TTH RS01920
gene id: 300852:TTH_RS01920
uniprot id: Q5SLC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

300852:TTH RS07465
gene id: 300852:TTH_RS07465
uniprot id: Q5SIA0
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS10995
gene id: 300852:TTH_RS10995
uniprot id: Q53WG4
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

300852:TTH RS08035
gene id: 300852:TTH_RS08035
uniprot id: Q5SHZ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

300852:TTH RS07075
gene id: 300852:TTH_RS07075
uniprot id: P80380
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the bottom of the body of the 30S subunit, by binding to several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit.

300852:TTH RS00450
gene id: 300852:TTH_RS00450
uniprot id: Q56219
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 15 different subunits, Nqo1 to Nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8 and Nqo10 to Nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9 and Nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers. The N-terminal domain of this subunit (residues 1 to 153) wraps around Nqo4 on one side, and the subunit interacts also with Nqo9 via a two-stranded beta sheet (residues 154 to 171) and with Nqo3 via an extended C-terminal loop (residues 172 to 196).
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP. The Nqo5 subunit may be involved in the stabilization of the complex.

300852:TTH RS00445
gene id: 300852:TTH_RS00445
uniprot id: Q56218
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster per subunit. This [4Fe-4S] cluster is referred to as N2.
messages: Cell membrane
messages: NDH-1 is composed of 15 different subunits, Nqo1 to Nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8 and Nqo10 to Nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9 and Nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers. This subunit interacts extensively with Nqo4.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP.

300852:TTH RS03085
gene id: 300852:TTH_RS03085
uniprot id: Q5SKP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 7 family.
messages: Homodimer.
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: Periplasm

300852:TTH RS01625
gene id: 300852:TTH_RS01625
uniprot id: Q5SLI3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell inner membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: In the N-terminal section; belongs to the COX15/CtaA family.

300852:TTH RS01965
gene id: 300852:TTH_RS01965
uniprot id: Q5SLC0
names: Similarity
messages: Belongs to the UbiD family.

300852:TTH RS07890
gene id: 300852:TTH_RS07890
uniprot id: Q5SI22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

300852:TTH RS11160
gene id: 300852:TTH_RS11160
uniprot id: Q5SJJ0
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

300852:TTH RS04670
gene id: 300852:TTH_RS04670
uniprot id: P09403
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

300852:TTH RS07695
gene id: 300852:TTH_RS07695
uniprot id: Q5SMH7
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

300852:TTH RS07060
gene id: 300852:TTH_RS07060
uniprot id: Q5SIH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

300852:TTH RS05415
gene id: 300852:TTH_RS05415
uniprot id: Q5SJF0
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

300852:TTH RS05985
gene id: 300852:TTH_RS05985
uniprot id: Q5SJ34
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

300852:TTH RS10425
gene id: 300852:TTH_RS10425
uniprot id: Q53W75
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

300852:TTH RS04395
gene id: 300852:TTH_RS04395
uniprot id: Q5SK01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

300852:TTH RS05760
gene id: 300852:TTH_RS05760
uniprot id: Q5SJ80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Cell membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

300852:TTH RS07990
gene id: 300852:TTH_RS07990
uniprot id: Q5SI02
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

300852:TTH RS03570
gene id: 300852:TTH_RS03570
uniprot id: Q5SKF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

300852:TTH RS04865
gene id: 300852:TTH_RS04865
uniprot id: Q5SJQ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

300852:TTH RS07650
gene id: 300852:TTH_RS07650
uniprot id: Q5SI63
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

300852:TTH RS00635
gene id: 300852:TTH_RS00635
uniprot id: Q5SM23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity).
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer (Probable). Binds to the 30S ribosomal subunit, between the head and platform, contacting the 16S rRNA. Contacts ribosomal proteins S7 and S18 and may contact proteins S2 and S11.
messages: The Era binding site on the 30S subunit overlaps that of protein S1 and is in direct contact with 5 nucleotides directly upstream of the anti-Shine-Dalgarno sequence; the presence of Era may prevent mRNA recruitment. 30S subunits bound to Era are not able to bind to the 50S subunit to make functional ribosomes. Era may serve a role in the final stages of 30S ribosomal subunit assembly.

300852:TTH RS00505
gene id: 300852:TTH_RS00505
uniprot id: Q56229
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 15 different subunits, Nqo1 to Nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8 and Nqo10 to Nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9 and Nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP.

300852:TTH RS01705
gene id: 300852:TTH_RS01705
uniprot id: Q5SLH0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

300852:TTH RS09705
gene id: 300852:TTH_RS09705
uniprot id: Q5SH16
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.
messages: Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway.

300852:TTH RS02810
gene id: 300852:TTH_RS02810
uniprot id: Q5SKV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

300852:TTH RS01050
gene id: 300852:TTH_RS01050
uniprot id: Q5SLU2
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

300852:TTH RS04880
gene id: 300852:TTH_RS04880
uniprot id: Q5SJP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FADH(2)-utilizing monooxygenase family.
messages: Homotetramer consisting of a dimer of dimers. 4-HPA 3-monooxygenase consists of a reductase component HpaC and an oxygenase component HpaB.
messages: Utilizes FADH(2) supplied by HpaC, to catalyze the hydroxylation of 4-hydroxyphenylacetic acid, leading to the production of 3,4-dihydroxyphenylacetic acid (DHPA).

300852:TTH RS09235
gene id: 300852:TTH_RS09235
uniprot id: Q5SHB1
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

300852:TTH RS08015
gene id: 300852:TTH_RS08015
uniprot id: P29749
names: Function
names: Similarity
messages: A gamma subtype methylase, recognizes the double-stranded sequence 5'-TCGA-3', methylates A-4 on both strands and protects the DNA from cleavage by the TthHB8I endonuclease.
messages: Belongs to the N(4)/N(6)-methyltransferase family.

300852:TTH RS05785
gene id: 300852:TTH_RS05785
uniprot id: Q5SJ75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

300852:TTH RS08785
gene id: 300852:TTH_RS08785
uniprot id: Q5SHJ5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

300852:TTH RS02880
gene id: 300852:TTH_RS02880
uniprot id: Q5SKU1
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Part of the 50S ribosomal subunit.

300852:TTH RS03110
gene id: 300852:TTH_RS03110
uniprot id: Q5SKP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

300852:TTH RS04515
gene id: 300852:TTH_RS04515
uniprot id: Q5SJX7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

300852:TTH RS00325
gene id: 300852:TTH_RS00325
uniprot id: Q5SM81
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

300852:TTH RS07870
gene id: 300852:TTH_RS07870
uniprot id: Q5SI26
names: Function
names: Subunit
messages: Binds to glutamine synthetase and cystathionine beta-lyase. May be utilized for the efficient use of nitrogen in the global nitrogen regulation of T.thermophilus.
messages: Interacts with glutamine synthetase (TTHA1329) and cystathionine beta-lyase (TTHA1620), but proteins do not form a ternary complex.

300852:TTH RS02965
gene id: 300852:TTH_RS02965
uniprot id: Q5SKS4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit. Contains one structural ion and one catalytic ion that may be less tightly bound at the site.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Cytoplasm
messages: Homotetramer.

300852:TTH RS07545
gene id: 300852:TTH_RS07545
uniprot id: Q56236
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
messages: Required to stimulate the ATPase activity of DnaK.

300852:TTH RS00030
gene id: 300852:TTH_RS00030
uniprot id: Q5SMD7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

300852:TTH RS05455
gene id: 300852:TTH_RS05455
uniprot id: Q5SJE2
names: Function
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

300852:TTH RS07750
gene id: 300852:TTH_RS07750
uniprot id: Q5SI49
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

300852:TTH RS08010
gene id: 300852:TTH_RS08010
uniprot id: Q5SHZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide (By similarity). Can also use pimeloyl-CoA instead of pimeloyl-ACP as substrate. It also converts 2-amino-3-ketobutyrate and CoA to glycine and acetyl-CoA. Activity is also observed with the following combinations of substrates: acetyl-CoA and either L-alanine or L-serine, pimeloyl-CoA and either glycine or L-serine, and palmitoyl-CoA with L-alanine.
messages: Homodimer.

300852:TTH RS01210
gene id: 300852:TTH_RS01210
uniprot id: Q5SLR1
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

300852:TTH RS04070
gene id: 300852:TTH_RS04070
uniprot id: Q5SMG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

300852:TTH RS07120
gene id: 300852:TTH_RS07120
uniprot id: Q5SIG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

300852:TTH RS05735
gene id: 300852:TTH_RS05735
uniprot id: Q5SJ85
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Cells lacking this gene show a significant defect of growth at 78 degrees Celsius and accumulate N1-aminopropylagmatine. The double mutant of speB and speE shows defective growth at 70 degrees Celsius and significant defective growth at 78 degrees Celsius. It accumulates agmatine and N1-aminopropylagmatine.
messages: Cytoplasm
messages: In T.thermophilus, the biosynthetic pathways of spermidine operates via N1-aminopropylagmatine without the production of putrescine.
messages: Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high-temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the decarboxylation of N1-(3-aminopropyl)agmatine to yield spermidine and urea. It cannot use agmatine as substrate.

300852:TTH RS08660
gene id: 300852:TTH_RS08660
uniprot id: Q5SHM0
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

300852:TTH RS06575
gene id: 300852:TTH_RS06575
uniprot id: P23395
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

300852:TTH RS02340
gene id: 300852:TTH_RS02340
uniprot id: Q5SL43
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS00520
gene id: 300852:TTH_RS00520
uniprot id: Q5SM43
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS08560
gene id: 300852:TTH_RS08560
uniprot id: Q5SHN8
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.
messages: The mass differences between the observed and calculated masses are suggested to be due to methylation, which is known to occur in the E.coli and R.palustris orthologs.

300852:TTH RS07165
gene id: 300852:TTH_RS07165
uniprot id: Q5SIF4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SoxA family.
messages: Binds 2 heme groups per subunit.
messages: Heterodimer of SoxA and SoxX.
messages: Periplasm

300852:TTH RS10525
gene id: 300852:TTH_RS10525
uniprot id: Q53W55
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

300852:TTH RS06025
gene id: 300852:TTH_RS06025
uniprot id: Q5SJ28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm
messages: Homotetramer, in solution and in the crystal structure.

300852:TTH RS05335
gene id: 300852:TTH_RS05335
uniprot id: Q5SJG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flotillin-like FloA family.
messages: Cell membrane
messages: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.
messages: Homooligomerizes.
messages: Membrane raft

300852:TTH RS02015
gene id: 300852:TTH_RS02015
uniprot id: Q5SLA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

300852:TTH RS01080
gene id: 300852:TTH_RS01080
uniprot id: Q5SLT6
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

300852:TTH RS07050
gene id: 300852:TTH_RS07050
uniprot id: Q5SIH7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-66 and Arg-69) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

300852:TTH RS08850
gene id: 300852:TTH_RS08850
uniprot id: Q5SHI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

300852:TTH RS01695
gene id: 300852:TTH_RS01695
uniprot id: Q5SLH2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

300852:TTH RS07025
gene id: 300852:TTH_RS07025
uniprot id: Q5SII2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosines at positions 1400 (m5C1400), 1404 (m5C1404) and 1407 (m5C1407) of 16S rRNA. C1400, C1404 and C1407 are methylated in a 30S subunit substrate, but only C1400 and C1404 are methylated when naked 16S rRNA is the substrate. Methylation by RsmF may facilitate growth at temperatures outside the optimal growth temperature.

300852:TTH RS08415
gene id: 300852:TTH_RS08415
uniprot id: Q9Z9H5
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

300852:TTH RS04400
gene id: 300852:TTH_RS04400
uniprot id: Q5SK00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

300852:TTH RS08715
gene id: 300852:TTH_RS08715
uniprot id: Q5SHL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

300852:TTH RS04160
gene id: 300852:TTH_RS04160
uniprot id: Q5SK48
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is likely coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

300852:TTH RS11045
gene id: 300852:TTH_RS11045
uniprot id: Q53VX0
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.

300852:TTH RS04575
gene id: 300852:TTH_RS04575
uniprot id: Q5SJW4
names: Similarity
messages: Belongs to the peptidase C15 family.

300852:TTH RS05890
gene id: 300852:TTH_RS05890
uniprot id: Q5SJ53
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS02625
gene id: 300852:TTH_RS02625
uniprot id: Q5SKZ0
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

300852:TTH RS09205
gene id: 300852:TTH_RS09205
uniprot id: Q8RQE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

300852:TTH RS10985
gene id: 300852:TTH_RS10985
uniprot id: Q53WG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

300852:TTH RS05300
gene id: 300852:TTH_RS05300
uniprot id: Q5SJG7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS06150
gene id: 300852:TTH_RS06150
uniprot id: Q5SJ03
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

300852:TTH RS01010
gene id: 300852:TTH_RS01010
uniprot id: Q5SLV0
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS04200
gene id: 300852:TTH_RS04200
uniprot id: Q5SK40
names: Similarity
messages: Belongs to the GARS family.

300852:TTH RS04680
gene id: 300852:TTH_RS04680
uniprot id: Q5SJV0
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

300852:TTH RS01885
gene id: 300852:TTH_RS01885
uniprot id: Q5SLD4
names: Subcellular Location Annotation
messages: Cytoplasm

300852:TTH RS03105
gene id: 300852:TTH_RS03105
uniprot id: Q5SKP5
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS09865
gene id: 300852:TTH_RS09865
uniprot id: Q5SGY8
names: Similarity
messages: Belongs to the SCO1/2 family.

300852:TTH RS10570
gene id: 300852:TTH_RS10570
uniprot id: Q53W50
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

300852:TTH RS05255
gene id: 300852:TTH_RS05255
uniprot id: Q5SJH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

300852:TTH RS09905
gene id: 300852:TTH_RS09905
uniprot id: Q5SGY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

300852:TTH RS06300
gene id: 300852:TTH_RS06300
uniprot id: Q5SIX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

300852:TTH RS01510
gene id: 300852:TTH_RS01510
uniprot id: Q5SLK7
names: Similarity
messages: Belongs to the peptidase S8 family.

300852:TTH RS03120
gene id: 300852:TTH_RS03120
uniprot id: Q5SKP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS06535
gene id: 300852:TTH_RS06535
uniprot id: Q5SIS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

300852:TTH RS05240
gene id: 300852:TTH_RS05240
uniprot id: Q5SJH9
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

300852:TTH RS02540
gene id: 300852:TTH_RS02540
uniprot id: Q5SL05
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

300852:TTH RS06875
gene id: 300852:TTH_RS06875
uniprot id: Q5SIL0
names: Disruption Phenotype
names: Function
names: Induction
names: Subunit
messages: Activates transcription. The consensus DNA-binding site of this transcriptional regulator is 5'-WWGTGAN(5-7)ACACWW-3' in which W is A or T and N is G, A, T or C. Regulated genes include those encoding proteins involved in nutrient and energy supply, redox control and polyadenylation of mRNA (PubMed:18699868). Also regulates genes involved in oxidative stress response such as genes encoding manganese superoxide dismutase and catalase, and genes encoding a protein involved in nucleotide excision repair of damaged DNA and putative proteins involved in redox control, protein degradation and transcriptional regulation (PubMed:21054499).
messages: Homodimer.
messages: Increased expression during the stationary phase when grown at 70 degrees Celsius (PubMed:18699868). Increased expression during the logarithmic growth phase in oxidative stress and upon treatment with diamide. Increased expression by heavy metal ion, antibiotic, high salt and organic solvent stresses (PubMed:21054499).
messages: Viable, but has growth defects, particularly when grown in a synthetic medium. Increased sensitivity to disulfide stress. Decreased expression of TTHA0986, TTHA0770, TTHA0337, TTHA1028, TTHA0654, TTHA0655, TTHA0769, TTHA0425, TTHA0634, TTHA0635, TTHA0636, TTHA0637, TTHA0638, TTHA0570, TTHA0030, TTHA0460, TTHB243, TTHA1128, TTHA0035, TTHA0520 and TTHA1803 genes.

300852:TTH RS03635
gene id: 300852:TTH_RS03635
uniprot id: P48515
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).

300852:TTH RS02210
gene id: 300852:TTH_RS02210
uniprot id: Q5SL69
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

300852:TTH RS05175
gene id: 300852:TTH_RS05175
uniprot id: Q5SJJ1
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

300852:TTH RS09595
gene id: 300852:TTH_RS09595
uniprot id: Q56243
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex (By similarity).
messages: The ATPase activity is stimulated by single-stranded DNA. UvrB is stable up to 80 Celsius degrees.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity).
messages: The beta-hairpin motif is involved in DNA binding.

300852:TTH RS08085
gene id: 300852:TTH_RS08085
uniprot id: Q5SHY3
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS06650
gene id: 300852:TTH_RS06650
uniprot id: Q5SIQ6
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS07985
gene id: 300852:TTH_RS07985
uniprot id: Q5SI03
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

300852:TTH RS09395
gene id: 300852:TTH_RS09395
uniprot id: Q5SH78
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

300852:TTH RS08895
gene id: 300852:TTH_RS08895
uniprot id: Q5SHH5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the transfer of the amino group of L-glutamate to [LysW]-aminoadipate 6-semialdehyde, generating [LysW]-gamma-L-lysine.
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS00305
gene id: 300852:TTH_RS00305
uniprot id: Q5SM85
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

300852:TTH RS09025
gene id: 300852:TTH_RS09025
uniprot id: Q5SHF0
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

300852:TTH RS04815
gene id: 300852:TTH_RS04815
uniprot id: Q5SJR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

300852:TTH RS01135
gene id: 300852:TTH_RS01135
uniprot id: Q5SLS5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

300852:TTH RS10015
gene id: 300852:TTH_RS10015
uniprot id: Q9X9D5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
messages: Some 16-18 DnaA protein molecules bind their sites in oriC.

300852:TTH RS06980
gene id: 300852:TTH_RS06980
uniprot id: Q5SIJ1
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the NAD(+)-dependent oxidative decarboxylation of homoisocitrate to 2-oxoadipate (alpha-ketoadipate), a reaction involved in lysine biosynthesis through the alpha-aminoadipate pathway (PubMed:21813504). In addition, has high activity with isocitrate, but is inactive with 3-isopropylmalate (By similarity).
messages: Competitively inhibited by (2S,3S)-thiahomoisocitrate in vitro.
messages: Homotetramer. Dimer of dimers. The homotetramer can transiently dissociate into homodimers.

300852:TTH RS07675
gene id: 300852:TTH_RS07675
uniprot id: Q5SI58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

300852:TTH RS05720
gene id: 300852:TTH_RS05720
uniprot id: Q76G20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).

300852:TTH RS00005
gene id: 300852:TTH_RS00005
uniprot id: Q5SME2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

300852:TTH RS08540
gene id: 300852:TTH_RS08540
uniprot id: Q5SHP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Located at the top of the head of the 30S subunit, extending towards the 50S subunit, which it may contact in the 70S complex. Contacts several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a loose dimer with protein S13.

300852:TTH RS09185
gene id: 300852:TTH_RS09185
uniprot id: Q5SHC1
names: Similarity
messages: Belongs to the peptidase S33 family.

300852:TTH RS02555
gene id: 300852:TTH_RS02555
uniprot id: Q5SL02
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

300852:TTH RS08445
gene id: 300852:TTH_RS08445
uniprot id: Q5SHR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Binds to the 30S ribosomal subunit, contacting protein S12 and the 16S rRNA (ECO:0000269|PubMed:11228145). Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Binds in the vicinity of the A-site (ECO:0000269|PubMed:11228145). Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

300852:TTH RS08480
gene id: 300852:TTH_RS08480
uniprot id: Q5SHQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and probably the 23S rRNA; has been isolated in a complex with the 5S rRNA and RL25 (Ref.2).
messages: This is one of the proteins that binds and mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

300852:TTH RS08435
gene id: 300852:TTH_RS08435
uniprot id: P80377
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome structure it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the top of the two subunits; these bridges are in contact with the A site and P site tRNAs respectively and are implicated in movement during ribosome translocation. Separately contacts the tRNAs in the A and P sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome, contacting protein L5 and the 23S rRNA; these bridges are straddled by the 5S rRNA.

300852:TTH RS10705
gene id: 300852:TTH_RS10705
uniprot id: Q53W27
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS06555
gene id: 300852:TTH_RS06555
uniprot id: Q5SIS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

300852:TTH RS08265
gene id: 300852:TTH_RS08265
uniprot id: Q5SHU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

300852:TTH RS05320
gene id: 300852:TTH_RS05320
uniprot id: Q5SJG3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

300852:TTH RS00705
gene id: 300852:TTH_RS00705
uniprot id: Q5SM09
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

300852:TTH RS02390
gene id: 300852:TTH_RS02390
uniprot id: Q5SL33
names: Similarity
messages: Belongs to the Nudix hydrolase family.

300852:TTH RS07690
gene id: 300852:TTH_RS07690
uniprot id: Q5SMH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

300852:TTH RS08100
gene id: 300852:TTH_RS08100
uniprot id: Q5SHY0
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

300852:TTH RS04485
gene id: 300852:TTH_RS04485
uniprot id: Q5SJY4
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.
messages: Cytoplasm

300852:TTH RS10415
gene id: 300852:TTH_RS10415
uniprot id: Q53W77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

300852:TTH RS07205
gene id: 300852:TTH_RS07205
uniprot id: Q5SME3
names: Function
names: PTM
messages: Binds 1 heme c group covalently per subunit.
messages: This monoheme basic protein appears to function as an electron donor to cytochrome oxidase in T.thermophilus.

300852:TTH RS09790
gene id: 300852:TTH_RS09790
uniprot id: Q5SH03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

300852:TTH RS06145
gene id: 300852:TTH_RS06145
uniprot id: Q5SJ04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

300852:TTH RS01190
gene id: 300852:TTH_RS01190
uniprot id: Q5SLR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BCKDHA family.
messages: Heterotetramer of two alpha and two beta chains. Directly associated with ODBB in the E1 complex.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).

300852:TTH RS01760
gene id: 300852:TTH_RS01760
uniprot id: Q5SLF9
names: Similarity
messages: Belongs to the UPF0166 family.

300852:TTH RS08820
gene id: 300852:TTH_RS08820
uniprot id: Q5SHI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

300852:TTH RS01095
gene id: 300852:TTH_RS01095
uniprot id: Q8VVE2
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation. It extends beyond the surface of the 70S ribosome. The stalk is preferentially stabilized in 70S versus 50S crystals.
messages: Homodimer. Part of the 50S ribosomal subunit; present in 6 copies per ribosome. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which 3 L12 dimers bind in a sequential fashion. Contacts protein L11.
messages: The ion at m/z 12978 is suggested to be the N-acetylated form of the protein (L7). The ion at m/z 12964 is suggested to be consistent with dimethylation or formylation and is present in very small quantities in the sample.
messages: The ion at m/z 13016 is probably phosphorylated; treatment with phosphatase in the presence of kinase inhibitors decreases it weight. This form is only detected on 70S ribosomes and not in isolated ribosomal stalk complexes.

300852:TTH RS08310
gene id: 300852:TTH_RS08310
uniprot id: Q5SHT8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

300852:TTH RS00995
gene id: 300852:TTH_RS00995
uniprot id: Q5SLV3
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

300852:TTH RS06250
gene id: 300852:TTH_RS06250
uniprot id: Q5SIY4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS02785
gene id: 300852:TTH_RS02785
uniprot id: Q5SKV9
names: Similarity
messages: Belongs to the aspartokinase family.

300852:TTH RS09730
gene id: 300852:TTH_RS09730
uniprot id: Q5SH10
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

300852:TTH RS01020
gene id: 300852:TTH_RS01020
uniprot id: Q5SLU8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

300852:TTH RS09360
gene id: 300852:TTH_RS09360
uniprot id: P05378
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Feedback inhibited by tryptophan.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).

300852:TTH RS01130
gene id: 300852:TTH_RS01130
uniprot id: Q5SLS6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

300852:TTH RS00950
gene id: 300852:TTH_RS00950
uniprot id: Q5SLW2
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

300852:TTH RS07535
gene id: 300852:TTH_RS07535
uniprot id: P77527
names: Function
names: PTM
names: Subunit
messages: Forms a heterononamer with DnaK and DnaJ. Three copies of each protein are present in the complex.
messages: Required for correct assembly of the DnaK-DnaJ complex in the resting state. Seems to stabilize this ternary complex until it is replaced by substrate proteins under heat-shock conditions.
messages: The N-terminus is blocked.

300852:TTH RS02735
gene id: 300852:TTH_RS02735
uniprot id: Q5SKW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

300852:TTH RS00610
gene id: 300852:TTH_RS00610
uniprot id: Q5SM27
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

300852:TTH RS02375
gene id: 300852:TTH_RS02375
uniprot id: Q5SL36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

300852:TTH RS02335
gene id: 300852:TTH_RS02335
uniprot id: Q5SL44
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS00555
gene id: 300852:TTH_RS00555
uniprot id: Q5SM37
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

300852:TTH RS05430
gene id: 300852:TTH_RS05430
uniprot id: P56690
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)) (By similarity).
messages: Monomer.
messages: The ATP consumption with regard to L-valine is nonproductive and is solely for substrate selection, which demonstrates the high cost of accuracy.

300852:TTH RS03010
gene id: 300852:TTH_RS03010
uniprot id: Q5SKR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

300852:TTH RS10245
gene id: 300852:TTH_RS10245
uniprot id: Q53WB1
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

300852:TTH RS07625
gene id: 300852:TTH_RS07625
uniprot id: Q5SI68
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

300852:TTH RS05950
gene id: 300852:TTH_RS05950
uniprot id: Q5SJ41
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS03265
gene id: 300852:TTH_RS03265
uniprot id: Q5SKL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

300852:TTH RS01780
gene id: 300852:TTH_RS01780
uniprot id: Q5SLF5
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

300852:TTH RS05130
gene id: 300852:TTH_RS05130
uniprot id: Q5SJJ8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

300852:TTH RS08845
gene id: 300852:TTH_RS08845
uniprot id: Q5SHI5
names: Similarity
messages: Belongs to the archease family.

300852:TTH RS09130
gene id: 300852:TTH_RS09130
uniprot id: Q5SHD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

300852:TTH RS04760
gene id: 300852:TTH_RS04760
uniprot id: Q5SJS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

300852:TTH RS00465
gene id: 300852:TTH_RS00465
uniprot id: Q56222
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 51 kDa subunit family.
messages: Binds 1 FMN per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit. This [4Fe-4S] cluster is referred to as N3.
messages: Cell membrane
messages: NDH-1 is composed of 15 different subunits, Nqo1 to Nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8 and Nqo10 to Nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9 and Nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP. The Nqo1 subunit contains the NADH-binding site and the primary electron acceptor FMN.
messages: The subunit can be separated roughly into four domains: an N-terminal domain (residues 7 to 72) ending with a glycine-rich loop, followed by a Rossman-fold domain (73 to 240), a ubiquitin-like domain (241 to 335) and a C-terminal four-helical bundle containing cluster N3 (336 to 438).

300852:TTH RS07680
gene id: 300852:TTH_RS07680
uniprot id: Q5SI57
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

300852:TTH RS09110
gene id: 300852:TTH_RS09110
uniprot id: Q5SHD6
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

300852:TTH RS01710
gene id: 300852:TTH_RS01710
uniprot id: Q5SLG9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

300852:TTH RS07930
gene id: 300852:TTH_RS07930
uniprot id: Q5SI14
names: Similarity
messages: Belongs to the BshC family.

300852:TTH RS02775
gene id: 300852:TTH_RS02775
uniprot id: Q5SKW1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

300852:TTH RS02360
gene id: 300852:TTH_RS02360
uniprot id: Q5SL39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

300852:TTH RS00605
gene id: 300852:TTH_RS00605
uniprot id: Q5SM28
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). Can inadvertently accommodate and process cysteine.
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension. The C-terminal extension binds a zinc ion, which probably plays a non-essential structural role in stabilizing the fold of C-terminal domain.
messages: Cytoplasm
messages: Homodimer. Only one tRNA molecule binds per dimer.

300852:TTH RS05365
gene id: 300852:TTH_RS05365
uniprot id: P52028
names: Similarity
messages: Belongs to the DNA polymerase type-A family.

300852:TTH RS10220
gene id: 300852:TTH_RS10220
uniprot id: Q53WB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell inner membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

300852:TTH RS00095
gene id: 300852:TTH_RS00095
uniprot id: Q5SMC7
names: Function
names: Similarity
messages: Belongs to the Dus family. DusA subfamily.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.

300852:TTH RS02795
gene id: 300852:TTH_RS02795
uniprot id: Q5SKV7
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

300852:TTH RS08505
gene id: 300852:TTH_RS08505
uniprot id: Q5SHP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

300852:TTH RS06045
gene id: 300852:TTH_RS06045
uniprot id: Q5SJ24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

300852:TTH RS01465
gene id: 300852:TTH_RS01465
uniprot id: Q5SLL5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by calcium.
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Dimer of dimers.
messages: Involved in gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA (By similarity).

300852:TTH RS05305
gene id: 300852:TTH_RS05305
uniprot id: Q5SJG6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GreA/GreB family.
messages: Inhibitory activity is regulated via a pH-induced conformational change of the structure. At pH above 7, Gfh1 is in an inactive flipped orientation that prevents binding to RNAP. At lower pH, Gfh1 switches to an active orientation, which enables binding to RNAP and inhibitory activity (By similarity).
messages: Inhibits all catalytic activities of RNA polymerase (RNAP) by partially occluding its substrate-binding site and preventing NTP binding.
messages: Interacts with RNAP.

300852:TTH RS07585
gene id: 300852:TTH_RS07585
uniprot id: Q5SI76
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

300852:TTH RS06730
gene id: 300852:TTH_RS06730
uniprot id: Q5SIP0
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity increases by approximately two-fold in the presence of GCBP.
messages: Belongs to the glutamine synthetase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
messages: Cytoplasm
messages: Interacts with GCBP (TTHA1554).

300852:TTH RS01380
gene id: 300852:TTH_RS01380
uniprot id: Q5SLN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

300852:TTH RS06310
gene id: 300852:TTH_RS06310
uniprot id: Q5SIX1
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

300852:TTH RS02445
gene id: 300852:TTH_RS02445
uniprot id: Q5SL22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

300852:TTH RS02845
gene id: 300852:TTH_RS02845
uniprot id: Q5SKU8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS04445
gene id: 300852:TTH_RS04445
uniprot id: P80371
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S8 and may contact the N-terminus of Era.
messages: Spans the head-body hinge region of the 30S subunit. Is loosely associated with the 30S subunit.

300852:TTH RS09225
gene id: 300852:TTH_RS09225
uniprot id: Q5SHB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

300852:TTH RS01745
gene id: 300852:TTH_RS01745
uniprot id: Q5SLG2
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

300852:TTH RS10950
gene id: 300852:TTH_RS10950
uniprot id: Q53VY1
names: Function
names: Similarity
names: Subunit
messages: A component of Cascade, which participates in CRISPR interference, the third stage of CRISPR immunity. Cascade binds both crRNA and in a sequence-specific manner negatively supercoiled dsDNA target. This leads to the formation of an R-loop in which the crRNA binds the target DNA, displacing the noncomplementary strand. Cas3 is recruited to Cascade, probably via interactions with CasA, nicks target DNA and then unwinds and cleaves the target, leading to DNA degradation and invader neutralization. CasA is not required for formation of Cascade, but probably enhances binding to and subsequent recognition of both target dsDNA and ssDNA (By similarity).
messages: Belongs to the CRISPR associated protein CasA/Cse1 family. Type I-E/Ecoli subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).
messages: Monomer. Part of the Cascade ribonucleoprotein complex. Interacts directly with the 5' end of crRNA, CasB, CasD and CasE. Binding of target ssRNA or dsDNA causes a conformational change in the Cascade complex; CasA is required for high affinity target DNA binding. Interacts with Cas3 once Cascade has recognized target DNA (By similarity).

300852:TTH RS10510
gene id: 300852:TTH_RS10510
uniprot id: Q53W58
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS02170
gene id: 300852:TTH_RS02170
uniprot id: Q5SL77
names: Similarity
messages: Belongs to the fabD family.

300852:TTH RS01995
gene id: 300852:TTH_RS01995
uniprot id: Q5SLB3
names: Similarity
messages: Belongs to the AOR/FOR family.

300852:TTH RS08325
gene id: 300852:TTH_RS08325
uniprot id: Q5SHT5
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Contains an N-terminal DNA-binding domain, followed by a dimerization domain and a C-terminal domain, called the small MutS-related (Smr) domain, which is absent from MutS and contains the endonuclease activity. The Smr domain can also bind DNA.
messages: Disruption causes an increase in the frequency of recombination between perfectly matched sequences.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity. Cleaves the phosphate backbone of oligodeoxynucleotides non-sequence-specifically at the 3' side of the phosphates. Preferably incises the branched DNA structures, especially the D-loop structure over the Holliday junction. Has ATPase activity. Binds to dsDNA but not to ssDNA.
messages: Homodimer. Interacts with MutL.
messages: Nuclease activity is stimulated by interaction with MutL. ATPase activity is stimulated by dsDNA.

300852:TTH RS02130
gene id: 300852:TTH_RS02130
uniprot id: Q5SL85
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

300852:TTH RS02075
gene id: 300852:TTH_RS02075
uniprot id: Q5SL96
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS00590
gene id: 300852:TTH_RS00590
uniprot id: Q5SM31
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

300852:TTH RS06135
gene id: 300852:TTH_RS06135
uniprot id: Q5SJ06
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

300852:TTH RS03210
gene id: 300852:TTH_RS03210
uniprot id: Q5SKM7
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

300852:TTH RS03820
gene id: 300852:TTH_RS03820
uniprot id: Q5SKB3
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

300852:TTH RS07530
gene id: 300852:TTH_RS07530
uniprot id: Q9RA63
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.
messages: The Clp repeat (R) domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer.

300852:TTH RS00490
gene id: 300852:TTH_RS00490
uniprot id: Q56226
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: NDH-1 is composed of 15 different subunits, Nqo1 to Nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8 and Nqo10 to Nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9 and Nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP.

300852:TTH RS05960
gene id: 300852:TTH_RS05960
uniprot id: Q5SJ39
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

300852:TTH RS04050
gene id: 300852:TTH_RS04050
uniprot id: Q5SK67
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

300852:TTH RS03355
gene id: 300852:TTH_RS03355
uniprot id: Q5SKK1
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

300852:TTH RS05630
gene id: 300852:TTH_RS05630
uniprot id: Q5SJA8
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS08980
gene id: 300852:TTH_RS08980
uniprot id: Q5SHF9
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

300852:TTH RS06810
gene id: 300852:TTH_RS06810
uniprot id: Q5SIM3
names: Similarity
messages: Belongs to the PGI/PMI family.

300852:TTH RS10175
gene id: 300852:TTH_RS10175
uniprot id: Q53WC6
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS02615
gene id: 300852:TTH_RS02615
uniprot id: Q5SKZ2
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

300852:TTH RS01015
gene id: 300852:TTH_RS01015
uniprot id: Q5SLU9
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS02135
gene id: 300852:TTH_RS02135
uniprot id: Q5SL84
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

300852:TTH RS07905
gene id: 300852:TTH_RS07905
uniprot id: Q8RQE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

300852:TTH RS05315
gene id: 300852:TTH_RS05315
uniprot id: Q5SJG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane

300852:TTH RS06685
gene id: 300852:TTH_RS06685
uniprot id: Q5SIP9
names: Similarity
messages: Belongs to the peptidase S1C family.

300852:TTH RS02750
gene id: 300852:TTH_RS02750
uniprot id: Q5SKW5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

300852:TTH RS08195
gene id: 300852:TTH_RS08195
uniprot id: Q5SHW1
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

300852:TTH RS01685
gene id: 300852:TTH_RS01685
uniprot id: Q5SLH4
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

300852:TTH RS03625
gene id: 300852:TTH_RS03625
uniprot id: Q5SKE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Conducts protons, which can be regulated by a proton gradient or by binding of an unfolded protein. Proton conduction requires the large periplasmic domain of the SecD.
messages: In the C-terminal section; belongs to the SecD/SecF family. SecF subfamily.
messages: In the N-terminal section; belongs to the SecD/SecF family. SecD subfamily.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
messages: Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary protein SecDF. Other proteins may also be involved (By similarity). Monomer.

300852:TTH RS04675
gene id: 300852:TTH_RS04675
uniprot id: Q5SJV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Interacts with the 30S ribosomal subunit as a monomer, binding in a position overlapping the sites of the A and P site tRNAs, and displacing segments of the 16S rRNA. Probably contacts 16S rRNA and ribosomal protein S9 and S13.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes) (PubMed:17996707). Required for efficient processing of 16S rRNA. Probably interacts with the 5'-terminal helix region of 16S rRNA, bringing together different domains of the 30S ribosomal subunit which aids assembly (PubMed:17996707).

300852:TTH RS04265
gene id: 300852:TTH_RS04265
uniprot id: Q5SK26
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.

300852:TTH RS08965
gene id: 300852:TTH_RS08965
uniprot id: Q5SHG2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

300852:TTH RS09795
gene id: 300852:TTH_RS09795
uniprot id: Q5SH02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

300852:TTH RS07995
gene id: 300852:TTH_RS07995
uniprot id: Q5SI01
names: Cofactor
messages: Binds 1 FAD per subunit.

300852:TTH RS06565
gene id: 300852:TTH_RS06565
uniprot id: Q5SIR8
names: Similarity
messages: Belongs to the peptidase S41A family.

300852:TTH RS09120
gene id: 300852:TTH_RS09120
uniprot id: Q5SHD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

300852:TTH RS08485
gene id: 300852:TTH_RS08485
uniprot id: P0DOY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

300852:TTH RS01690
gene id: 300852:TTH_RS01690
uniprot id: Q5SLH3
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

300852:TTH RS01990
gene id: 300852:TTH_RS01990
uniprot id: Q5SLB4
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

300852:TTH RS06770
gene id: 300852:TTH_RS06770
uniprot id: Q5SIN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

300852:TTH RS09915
gene id: 300852:TTH_RS09915
uniprot id: Q5SGX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

300852:TTH RS05110
gene id: 300852:TTH_RS05110
uniprot id: Q5SJK2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

300852:TTH RS03200
gene id: 300852:TTH_RS03200
uniprot id: Q5SKM9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

300852:TTH RS08510
gene id: 300852:TTH_RS08510
uniprot id: Q5SHP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Contacts the 16S rRNA of the 30S subunit in two different positions helping to form bridges B5 and B8.
messages: Part of the 50S ribosomal subunit. Contacts protein L19. Forms a bridge to the 30S subunit in the 70S ribosome, contacting the 16S rRNA.
messages: This protein binds directly to 23S ribosomal RNA.

300852:TTH RS00455
gene id: 300852:TTH_RS00455
uniprot id: Q56220
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 15 different subunits, Nqo1 to Nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8 and Nqo10 to Nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9 and Nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers. This subunit interacts extensively with Nqo6.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP. The Nqo4 subunit may contain the quinone-binding site.

300852:TTH RS03515
gene id: 300852:TTH_RS03515
uniprot id: Q5SKG9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

300852:TTH RS00385
gene id: 300852:TTH_RS00385
uniprot id: Q5SM69
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

300852:TTH RS05505
gene id: 300852:TTH_RS05505
uniprot id: Q5SJD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Membrane

300852:TTH RS07325
gene id: 300852:TTH_RS07325
uniprot id: Q5SIC7
names: Similarity
messages: Belongs to the AlaDH/PNT family.

300852:TTH RS05980
gene id: 300852:TTH_RS05980
uniprot id: Q5SJ35
names: Function
names: Similarity
messages: Belongs to the fructosamine kinase family.
messages: Ketoamine kinase that phosphorylates ketoamines, such as erythruloselysine and ribuloselysine, on the third carbon of the sugar moiety to generate ketoamine 3-phosphate (PubMed:17681011). Has higher activity on free lysine (erythruloselysine and ribuloselysine), than on ribuloselysine and erythruloselysine residues on glycated proteins (PubMed:17681011).

300852:TTH RS06545
gene id: 300852:TTH_RS06545
uniprot id: Q5SIS2
names: Similarity
messages: Belongs to the Fur family.

300852:TTH RS06560
gene id: 300852:TTH_RS06560
uniprot id: Q5SIR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

300852:TTH RS05590
gene id: 300852:TTH_RS05590
uniprot id: Q5SJB6
names: Similarity
messages: Belongs to the BMP lipoprotein family.

300852:TTH RS06460
gene id: 300852:TTH_RS06460
uniprot id: P74903
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

300852:TTH RS10955
gene id: 300852:TTH_RS10955
uniprot id: Q53VY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated CasB/Cse2 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).
messages: Homodimer.

300852:TTH RS04825
gene id: 300852:TTH_RS04825
uniprot id: Q5SJQ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS02370
gene id: 300852:TTH_RS02370
uniprot id: Q5SL37
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

300852:TTH RS00725
gene id: 300852:TTH_RS00725
uniprot id: Q5SM06
names: Similarity
messages: Belongs to the RutC family.

300852:TTH RS00275
gene id: 300852:TTH_RS00275
uniprot id: Q5SM91
names: Similarity
messages: Belongs to the histone deacetylase family.

300852:TTH RS03765
gene id: 300852:TTH_RS03765
uniprot id: Q5SMF7
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

300852:TTH RS03445
gene id: 300852:TTH_RS03445
uniprot id: Q5SKI3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

300852:TTH RS01300
gene id: 300852:TTH_RS01300
uniprot id: P35872
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

300852:TTH RS10370
gene id: 300852:TTH_RS10370
uniprot id: Q53W86
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

300852:TTH RS10205
gene id: 300852:TTH_RS10205
uniprot id: Q53WB9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

300852:TTH RS00905
gene id: 300852:TTH_RS00905
uniprot id: Q5SLX1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane

300852:TTH RS00920
gene id: 300852:TTH_RS00920
uniprot id: Q5SLW8
names: Subcellular Location Annotation
messages: Cytoplasm

300852:TTH RS02465
gene id: 300852:TTH_RS02465
uniprot id: Q5SL18
names: Similarity
messages: Belongs to the histone deacetylase family.

300852:TTH RS00295
gene id: 300852:TTH_RS00295
uniprot id: Q5SM87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

300852:TTH RS01515
gene id: 300852:TTH_RS01515
uniprot id: Q5SLK6
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

300852:TTH RS01440
gene id: 300852:TTH_RS01440
uniprot id: P61493
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

300852:TTH RS07630
gene id: 300852:TTH_RS07630
uniprot id: Q5SI67
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

300852:TTH RS04420
gene id: 300852:TTH_RS04420
uniprot id: Q5SJZ6
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

300852:TTH RS06745
gene id: 300852:TTH_RS06745
uniprot id: Q5SIN7
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS05425
gene id: 300852:TTH_RS05425
uniprot id: Q5SJE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

300852:TTH RS05405
gene id: 300852:TTH_RS05405
uniprot id: Q5SJF2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

300852:TTH RS05440
gene id: 300852:TTH_RS05440
uniprot id: Q5SJE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Membrane

300852:TTH RS01410
gene id: 300852:TTH_RS01410
uniprot id: Q5SLM7
names: Similarity
messages: Belongs to the peptidase C40 family.

300852:TTH RS06290
gene id: 300852:TTH_RS06290
uniprot id: Q5SIX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

300852:TTH RS01635
gene id: 300852:TTH_RS01635
uniprot id: P98005
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 copper B ion per subunit.
messages: Binds 2 heme groups per subunit.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.
messages: In the C-terminal section; belongs to the cytochrome c oxidase subunit 3 family.
messages: In the N-terminal section; belongs to the heme-copper respiratory oxidase family.
messages: Possibly a heterodimer of A-protein (contains: cytochrome c oxidase subunits I and III) and subunit II. The A-protein could also present a precursor form of subunits I and III.

300852:TTH RS07940
gene id: 300852:TTH_RS07940
uniprot id: Q5SI12
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: The tartarate seen in the active site in the crystallographic structure may partially mimic the substrate; it is suspected that the tartarate may resemble the open-chain form of the ribose part of the substrate, cyclic dehypoxanthine futalosine.

300852:TTH RS02490
gene id: 300852:TTH_RS02490
uniprot id: Q5SL13
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

300852:TTH RS01530
gene id: 300852:TTH_RS01530
uniprot id: Q5SLK3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

300852:TTH RS09860
gene id: 300852:TTH_RS09860
uniprot id: Q5SGY9
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS03385
gene id: 300852:TTH_RS03385
uniprot id: Q5SKJ4
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS06035
gene id: 300852:TTH_RS06035
uniprot id: Q5SJ26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

300852:TTH RS06445
gene id: 300852:TTH_RS06445
uniprot id: O87880
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

300852:TTH RS05780
gene id: 300852:TTH_RS05780
uniprot id: Q5SJ76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

300852:TTH RS04380
gene id: 300852:TTH_RS04380
uniprot id: Q9AJ99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

300852:TTH RS02230
gene id: 300852:TTH_RS02230
uniprot id: Q5SL65
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

300852:TTH RS01415
gene id: 300852:TTH_RS01415
uniprot id: Q5SLM6
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

300852:TTH RS10725
gene id: 300852:TTH_RS10725
uniprot id: Q53W23
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

300852:TTH RS01845
gene id: 300852:TTH_RS01845
uniprot id: Q5SLE2
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS08355
gene id: 300852:TTH_RS08355
uniprot id: Q5SHS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

300852:TTH RS04055
gene id: 300852:TTH_RS04055
uniprot id: Q5SK66
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

300852:TTH RS05385
gene id: 300852:TTH_RS05385
uniprot id: Q5SMH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

300852:TTH RS03460
gene id: 300852:TTH_RS03460
uniprot id: Q5SKI0
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

300852:TTH RS01170
gene id: 300852:TTH_RS01170
uniprot id: Q5SLR8
names: Caution
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS05100
gene id: 300852:TTH_RS05100
uniprot id: Q5SJK4
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

300852:TTH RS05835
gene id: 300852:TTH_RS05835
uniprot id: Q5SJ65
names: Function
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.
messages: DNA glycosylase with broad substrate specificity. Can remove uracil from double-stranded DNA containing either a U/G, U/A, U/C or U/T base pair (PubMed:12000829, PubMed:17870091, PubMed:24838246). Can also excise hypoxanthine from double-stranded DNA containing G/I, T/I, and A/I base pairs, xanthine from both double-stranded and single stranded DNA, thymine from G/T mismatched DNA, 5'-hydroxymethyluracil and 5'-fluorouracil (PubMed:17870091, PubMed:24838246).

300852:TTH RS02320
gene id: 300852:TTH_RS02320
uniprot id: P80340
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL34 family.
messages: Found on the solvent side of the large subunit.
messages: Part of the 50S ribosomal subunit.
messages: The open reading frame (ORF) for this protein is entirely within the ORF for the RNase P protein (RnaP). The two start codons are separated by four nucleotides.

300852:TTH RS00225
gene id: 300852:TTH_RS00225
uniprot id: P60494
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL28 family.
messages: Part of the 50S ribosomal subunit.

300852:TTH RS10490
gene id: 300852:TTH_RS10490
uniprot id: Q53W62
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CarA/CarH B12-binding photoregulator family.
messages: Homotetramer in the dark in the presence of cobalamin. Monomer in the light or in the absence of cobalamin.
messages: Negative regulator of genes involved in carotenoid biosynthesis.
messages: Requires cobalamin (vitamin B12) for repressor activity. In the dark, binding of cobalamin to CarH induces its oligomerization, which enhances binding to the DNA and repressor activity. Light causes cobalamin photolysis and disruption of the cobalamin-CarH complex, which decreases interaction with DNA and allows transcription of the target genes.
messages: The N-terminal region interacts with DNA, and the C-terminal region is involved in oligomerization and binding of cobalamin.

300852:TTH RS03705
gene id: 300852:TTH_RS03705
uniprot id: P56194
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS04600
gene id: 300852:TTH_RS04600
uniprot id: Q5SJW0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

300852:TTH RS08490
gene id: 300852:TTH_RS08490
uniprot id: P0DOY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit central domain. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S2, S5 and S12.

300852:TTH RS02905
gene id: 300852:TTH_RS02905
uniprot id: P61503
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.

300852:TTH RS06590
gene id: 300852:TTH_RS06590
uniprot id: Q5SIR3
names: Similarity
messages: Belongs to the BMP lipoprotein family.

300852:TTH RS06950
gene id: 300852:TTH_RS06950
uniprot id: Q5SIJ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS00040
gene id: 300852:TTH_RS00040
uniprot id: Q5SMD5
names: Similarity
messages: Belongs to the PspA/IM30 family.

300852:TTH RS01145
gene id: 300852:TTH_RS01145
uniprot id: Q5SLS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

300852:TTH RS04690
gene id: 300852:TTH_RS04690
uniprot id: Q5SJU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

300852:TTH RS04740
gene id: 300852:TTH_RS04740
uniprot id: Q5SJS7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

300852:TTH RS03030
gene id: 300852:TTH_RS03030
uniprot id: P68591
names: Similarity
messages: Belongs to the UPF0340 family.

300852:TTH RS00515
gene id: 300852:TTH_RS00515
uniprot id: Q5SM44
names: Similarity
messages: Belongs to the peptidase S1C family.

300852:TTH RS05480
gene id: 300852:TTH_RS05480
uniprot id: Q5SJD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

300852:TTH RS02385
gene id: 300852:TTH_RS02385
uniprot id: Q5SL34
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

300852:TTH RS08465
gene id: 300852:TTH_RS08465
uniprot id: Q5SHQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

300852:TTH RS00895
gene id: 300852:TTH_RS00895
uniprot id: P83700
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

300852:TTH RS02830
gene id: 300852:TTH_RS02830
uniprot id: P56206
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS04215
gene id: 300852:TTH_RS04215
uniprot id: Q5SK37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

300852:TTH RS03955
gene id: 300852:TTH_RS03955
uniprot id: Q5SK86
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

300852:TTH RS07565
gene id: 300852:TTH_RS07565
uniprot id: Q5SI80
names: Similarity
messages: Belongs to the peptidase S49 family.

300852:TTH RS02900
gene id: 300852:TTH_RS02900
uniprot id: Q5SKT7
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.
messages: Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Is highly specific to futalosine since it does not accept aminodeoxyfutalosine (AFL), or any structurally related nucleotides and nucleosides as substrate.
messages: Homotetramer.
messages: No enhancing of inhibitory effects are observed with divalent metal ions. Slightly inhibited by hypoxanthine.

300852:TTH RS04310
gene id: 300852:TTH_RS04310
uniprot id: Q5SK18
names: Similarity
messages: Belongs to the AP endonuclease 2 family.

300852:TTH RS07300
gene id: 300852:TTH_RS07300
uniprot id: Q5SID2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

300852:TTH RS06170
gene id: 300852:TTH_RS06170
uniprot id: Q5SIZ8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Cell outer membrane
messages: Membrane
messages: Periplasm

300852:TTH RS03435
gene id: 300852:TTH_RS03435
uniprot id: Q5SKI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

300852:TTH RS01035
gene id: 300852:TTH_RS01035
uniprot id: Q5SLU5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

300852:TTH RS06660
gene id: 300852:TTH_RS06660
uniprot id: Q5SIQ4
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS04610
gene id: 300852:TTH_RS04610
uniprot id: Q5SJV8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

300852:TTH RS03095
gene id: 300852:TTH_RS03095
uniprot id: Q5SKP7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

300852:TTH RS05510
gene id: 300852:TTH_RS05510
uniprot id: Q5SJD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

300852:TTH RS03815
gene id: 300852:TTH_RS03815
uniprot id: Q5SKB4
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS09320
gene id: 300852:TTH_RS09320
uniprot id: Q5SH94
names: Cofactor
messages: Can also use Mn(2+) ion.

300852:TTH RS06580
gene id: 300852:TTH_RS06580
uniprot id: Q5SIR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

300852:TTH RS07725
gene id: 300852:TTH_RS07725
uniprot id: Q5SI54
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

300852:TTH RS06795
gene id: 300852:TTH_RS06795
uniprot id: Q5SIM6
names: Similarity
messages: Belongs to the citrate synthase family.

300852:TTH RS08535
gene id: 300852:TTH_RS08535
uniprot id: Q5SHP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is one of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that penetrates into the center of the 70S ribosome. This extension seems to form part of the wall of the exit tunnel.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

300852:TTH RS08045
gene id: 300852:TTH_RS08045
uniprot id: Q5SHZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit. Contacts the 5S rRNA; has been isolated in a complex with 5S rRNA and RL5, 5S rRNA and DNA binding protein II; 5S rRNA and RL18; 5S rRNA, RL5 and DNA binding protein II (Ref.4).
messages: This is one of 3 proteins that mediate the attachment of the 5S rRNA onto the large ribosomal subunit.

300852:TTH RS09335
gene id: 300852:TTH_RS09335
uniprot id: Q5SH91
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

300852:TTH RS02525
gene id: 300852:TTH_RS02525
uniprot id: Q5SL08
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

300852:TTH RS03940
gene id: 300852:TTH_RS03940
uniprot id: Q5SK89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

300852:TTH RS07350
gene id: 300852:TTH_RS07350
uniprot id: Q5SIC2
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartate mischarged on tRNA(Asn) is then converted into asparagine by the tRNA-dependent amidotransferase GatCAB.
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn) with similar efficiencies. Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Constitutively expressed in a constant ratio along the growth of the bacterium.
messages: Cytoplasm
messages: Homodimer. Makes part of a ribonucleoprotein particle (RNP) called transamidosome that allows channelling of the aa-tRNA from non-discriminating aspartyl-tRNA synthetase active site to the GatCAB amidotransferase site. The transamidosome complex is formed by two GatCABs, one dimeric ND-AspRSs and two tRNAs(Asn) molecules.

300852:TTH RS09550
gene id: 300852:TTH_RS09550
uniprot id: Q5SH46
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

300852:TTH RS02915
gene id: 300852:TTH_RS02915
uniprot id: Q5SKT4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

300852:TTH RS04885
gene id: 300852:TTH_RS04885
uniprot id: Q5SJP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the non-flavoprotein flavin reductase family. HpaC subfamily.
messages: Catalyzes the reduction of free flavins (FMN, FAD and riboflavin) by NADH. Subsequently, the reduced flavins diffuse to the large HpaB component. It utilizes NADH, but not NADPH as an electron donor, and both FAD and FMN as electron acceptors.
messages: Homodimer. 4-HPA 3-monooxygenase consists of a reductase component HpaC and an oxygenase component HpaB.

300852:TTH RS07100
gene id: 300852:TTH_RS07100
uniprot id: Q5SIG7
names: Function
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Possible subunit of a heme lyase.

300852:TTH RS09875
gene id: 300852:TTH_RS09875
uniprot id: Q5SGY6
names: Similarity
messages: Belongs to the UPF0145 family.

300852:TTH RS01195
gene id: 300852:TTH_RS01195
uniprot id: Q5SLR3
names: Function
names: Subunit
messages: Heterotetramer of two alpha and two beta chains. Directly associated with ODBA in the E1 complex.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).

300852:TTH RS10340
gene id: 300852:TTH_RS10340
uniprot id: Q53W92
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

300852:TTH RS01155
gene id: 300852:TTH_RS01155
uniprot id: Q5SLS1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

300852:TTH RS03240
gene id: 300852:TTH_RS03240
uniprot id: Q5SKM1
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

300852:TTH RS08475
gene id: 300852:TTH_RS08475
uniprot id: Q5SHQ5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Is positioned such that it could physically interact with spectinomycin.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

300852:TTH RS10970
gene id: 300852:TTH_RS10970
uniprot id: Q53WG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family. Subtype I-E/Ecoli subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This enzyme processes pre-crRNA into individual crRNA units, but may not actually undergo enzyme turnover, retaining the crRNA product (PubMed:21572442). Generates a 2',3'-cyclic phosphodiester.
messages: Probably part of the Cascade ribonucleoprotein complex (Probable). Monomer, retains crRNA after it is processed.

300852:TTH RS10710
gene id: 300852:TTH_RS10710
uniprot id: Q53W26
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

300852:TTH RS04990
gene id: 300852:TTH_RS04990
uniprot id: Q5SJM6
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

300852:TTH RS09155
gene id: 300852:TTH_RS09155
uniprot id: Q5SHC7
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

300852:TTH RS05395
gene id: 300852:TTH_RS05395
uniprot id: Q5SMG8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC41A transporter family.
messages: Cell inner membrane
messages: Highly selective magnesium channel that plays an important role in Mg(2+) homeostasis (PubMed:17700703, PubMed:19798051, PubMed:25367295, PubMed:33905418). Functions as a Mg(2+)-dependent gating channel (PubMed:19798051, PubMed:25367295, PubMed:33905418). Exhibits low activity with cobalt, suggesting that it might also be involved in the uptake of Co(2+) as a micronutrient (PubMed:19798051). Also exhibits low activity with Ca(2+), but it shows almost no activity with Mn(2+) (PubMed:25367295).
messages: Homodimer.
messages: The channel activity is regulated via the N-terminal cytoplasmic region, which acts as a Mg(2+) sensor to regulate the gating of the ion-conducting pore in response to the intracellular magnesium concentration (PubMed:19798051, PubMed:25367295, PubMed:33905418). Under high-intracellular magnesium conditions, binding of magnesium to the N-terminal cytoplasmic domain stabilizes the closed conformation of the channel (PubMed:19798051, PubMed:25367295, PubMed:33905418). Under low-intracellular magnesium conditions, the channel is in equilibrium between the open and closed states (PubMed:19798051). A cation-binding site within the membrane (M1) strictly recognizes the size and geometry of the Mg(2+) hydration shells, which may be important for the selective transport of Mg(2+) over other cations (PubMed:25367295). Cation-binding sites on the periplasmic side (M2 and M3) regulate channel opening and prevent conduction of near-cognate cations (PubMed:25367295). Binding of Mn(2+) to the periplasmic sites strongly inhibits the Mg(2+) transport activity (PubMed:25367295). In addition, activity is regulated by ATP, which binds to MgtE and modulates its Mg(2+)-dependent channel gating (PubMed:28747715). ATP binding enhances the intracellular domain affinity for Mg(2+) within physiological concentrations of this divalent cation, enabling MgtE to function as an in vivo Mg(2+) sensor (PubMed:28747715). ATP dissociation from MgtE upregulates Mg(2+) influx at both high and low intracellular Mg(2+) concentrations (PubMed:28747715).

300852:TTH RS10735
gene id: 300852:TTH_RS10735
uniprot id: Q53W21
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.
messages: Probably encoded in a type III-A CRISPR locus.

300852:TTH RS08350
gene id: 300852:TTH_RS08350
uniprot id: Q5SHT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

300852:TTH RS07900
gene id: 300852:TTH_RS07900
uniprot id: Q5SI20
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS04755
gene id: 300852:TTH_RS04755
uniprot id: Q5SJS4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS01630
gene id: 300852:TTH_RS01630
uniprot id: Q5SLI2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Cell membrane
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

300852:TTH RS06855
gene id: 300852:TTH_RS06855
uniprot id: Q5SIL4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state (PubMed:23804759, PubMed:11850422). It probably also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes (PubMed:11850422). Relaxes negatively supercoiled DNA in an ATP-independent manner (PubMed:23804759, PubMed:11850422). At comparable concentrations T.thermophilus gyrase does not introduce as many negative supercoils into DNA as the E.coli enzyme (PubMed:23804759).
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: For the electron microscopy studies a GyrB-GyrA fusion protein was made with a Gly-Asp-Leu linker between the 2 subunits. It forms the expected dimer (PubMed:23804759).
messages: Heterotetramer, composed of two GyrA and two GyrB chains (PubMed:23804759). The two subunits form an intertwined dimer where the GyrB ATPase transducer helix of 1 subunit connects to the Toprim domain of the other GyrB subunit through a 10 residue linker (PubMed:23804759). In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with the DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.
messages: Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

300852:TTH RS05935
gene id: 300852:TTH_RS05935
uniprot id: Q5SJ44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

300852:TTH RS00580
gene id: 300852:TTH_RS00580
uniprot id: Q5SM33
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

300852:TTH RS03700
gene id: 300852:TTH_RS03700
uniprot id: Q5SKD2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp). Is specific for tRNA(Asp) since it aspartylates tRNA(Asn) 3 orders of magnitude less efficiently than tRNA(Asp).
messages: Constitutively expressed in a constant ratio along the growth of the bacterium.
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS05120
gene id: 300852:TTH_RS05120
uniprot id: Q5SJK0
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS00910
gene id: 300852:TTH_RS00910
uniprot id: Q5SLX0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

300852:TTH RS09855
gene id: 300852:TTH_RS09855
uniprot id: P96077
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Interacts with the ribosome (PubMed:16377566).
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1 (By similarity).
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (Probable).

300852:TTH RS01765
gene id: 300852:TTH_RS01765
uniprot id: Q5SLF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

300852:TTH RS02675
gene id: 300852:TTH_RS02675
uniprot id: Q5SKY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

300852:TTH RS01725
gene id: 300852:TTH_RS01725
uniprot id: Q5SLG6
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

300852:TTH RS03255
gene id: 300852:TTH_RS03255
uniprot id: Q5SKL8
names: Similarity
messages: Belongs to the CapA family.

300852:TTH RS10110
gene id: 300852:TTH_RS10110
uniprot id: Q53WE0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

300852:TTH RS06285
gene id: 300852:TTH_RS06285
uniprot id: Q5SIX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

300852:TTH RS10240
gene id: 300852:TTH_RS10240
uniprot id: Q53WB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

300852:TTH RS10945
gene id: 300852:TTH_RS10945
uniprot id: Q53VY2
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity. The N-terminal domain (residues 6-260) acts as a ssDNA endonuclease, has no activity on dsDNA.
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.
messages: Inhibited by EDTA, Mg(2+) and Ca(2+).
messages: Proteins of this family have an N-terminal nuclease domain and a C-terminal helicase/ATPase domain. In some CRISPR/Cas systems the domains are swapped, in others they are encoded separately.
messages: The ssDNA endonuclease activity (residues 6-260) is stimulated by Mn(2+), Co(2+), Ni(2+), Cu(2+) and Zn(2+), but not by Mg(2+) or Ca(2+). A Ni(2+) ion is seen in crystals upon soaking.

300852:TTH RS06090
gene id: 300852:TTH_RS06090
uniprot id: Q5SJ15
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS09405
gene id: 300852:TTH_RS09405
uniprot id: Q5SH76
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

300852:TTH RS05715
gene id: 300852:TTH_RS05715
uniprot id: Q5SJ90
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

300852:TTH RS10365
gene id: 300852:TTH_RS10365
uniprot id: Q53W87
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS01255
gene id: 300852:TTH_RS01255
uniprot id: Q5SLQ3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

300852:TTH RS05000
gene id: 300852:TTH_RS05000
uniprot id: Q5SJM4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

300852:TTH RS00485
gene id: 300852:TTH_RS00485
uniprot id: Q56225
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 15 different subunits, Nqo1 to Nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8 and Nqo10 to Nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9 and Nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP.

300852:TTH RS04315
gene id: 300852:TTH_RS04315
uniprot id: Q5SK17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

300852:TTH RS00585
gene id: 300852:TTH_RS00585
uniprot id: Q5SM32
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS09650
gene id: 300852:TTH_RS09650
uniprot id: Q5SH27
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Catalyzes the phosphorylation of LysW-gamma-alpha-aminoadipate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS01870
gene id: 300852:TTH_RS01870
uniprot id: Q5SLD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

300852:TTH RS01305
gene id: 300852:TTH_RS01305
uniprot id: P38383
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with SecDF, and other proteins may be involved. The channel interacts with SecA via subunit SecY.
messages: Essential subunit of the protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

300852:TTH RS02850
gene id: 300852:TTH_RS02850
uniprot id: Q5SKU7
names: Similarity
messages: Belongs to the TlyA family.

300852:TTH RS02420
gene id: 300852:TTH_RS02420
uniprot id: Q5SL28
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

300852:TTH RS07245
gene id: 300852:TTH_RS07245
uniprot id: Q5SIE3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dodecin family.
messages: Dodecin family members from different organisms have non-identical ligand binding specificity.
messages: Homododecamer; four homotrimers assemble to form a dodecameric hollow sphere with an outer diameter of about 60 Angstroms. Flavin dimers are bound between subunits with a stoichiometry of 6 flavin dimers per dodecamer. Besides, trimeric coenzyme A molecules can be bound between subunits. A dodecamer can bind simultaneously 12 flavin and 12 coenzyme A molecules.
messages: May function as storage protein that sequesters various flavins and other cofactors, thereby protecting the cell against undesirable reactions mediated by the free cofactors. Binds and sequesters FMN, FAD, lumiflavin and lumichrome, and can also bind coenzyme A.

300852:TTH RS01605
gene id: 300852:TTH_RS01605
uniprot id: Q5SLI8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

300852:TTH RS05615
gene id: 300852:TTH_RS05615
uniprot id: Q5SJB1
names: Similarity
messages: Belongs to the FemABX family.

300852:TTH RS01500
gene id: 300852:TTH_RS01500
uniprot id: P59846
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

300852:TTH RS04710
gene id: 300852:TTH_RS04710
uniprot id: Q56416
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

300852:TTH RS06330
gene id: 300852:TTH_RS06330
uniprot id: Q5SIW6
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

300852:TTH RS01270
gene id: 300852:TTH_RS01270
uniprot id: Q5SLQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Located on the back of the platform of the 30S subunit where it stabilizes the close packing of several RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome, where it probably interacts with the Shine-Dalgarno helix.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6, also interacts with protein S11. Binds to the C-terminus of IF3 and to the central section of Era.

300852:TTH RS04230
gene id: 300852:TTH_RS04230
uniprot id: Q5SK33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

300852:TTH RS10760
gene id: 300852:TTH_RS10760
uniprot id: Q53WF6
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

300852:TTH RS03830
gene id: 300852:TTH_RS03830
uniprot id: Q5SKB1
names: Similarity
messages: Belongs to the DapA family.

300852:TTH RS00440
gene id: 300852:TTH_RS00440
uniprot id: Q56217
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 15 different subunits, Nqo1 to Nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8 and Nqo10 to Nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9 and Nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP.

300852:TTH RS05855
gene id: 300852:TTH_RS05855
uniprot id: Q5SJ61
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

300852:TTH RS01555
gene id: 300852:TTH_RS01555
uniprot id: Q5SLJ8
names: Similarity
messages: Belongs to the universal stress protein A family.

300852:TTH RS01620
gene id: 300852:TTH_RS01620
uniprot id: Q5SLI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

300852:TTH RS09415
gene id: 300852:TTH_RS09415
uniprot id: Q5SH74
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS03675
gene id: 300852:TTH_RS03675
uniprot id: Q5SKD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

300852:TTH RS09645
gene id: 300852:TTH_RS09645
uniprot id: Q5SH28
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.
messages: Catalyzes the formation of branch points in alpha-glucans by cleavage of an alpha-1,4 glycosidic bond and subsequent transfer of the cleaved-off oligosaccharide to a new alpha-1,6 position. The branch chain-length distribution of the reaction products shows degree of polymerization (DP) of 3 to 13, with two local maxima at DP 7 and DP 11. Exhibits an alpha-retaining catalytic mechanism. Is involved in glycogen biosynthesis. Shows a secondary activity, i.e. the hydrolysis of the substrate, being 4% of the total activity. Can use amylose as substrate but not alpha-1,4-linked oligosaccharides of 2-7 glucose residues, beta-cyclodextrin, 6-O-glucosyl-beta-cyclodextrin and 6-O-maltosyl-beta-cyclodextrin. Is not able to branch amylopectin further, it only hydrolyzes amylopectin. Thus, displays preference for linear and long substrates (amylose) over branched structures (amylopectin).

300852:TTH RS02020
gene id: 300852:TTH_RS02020
uniprot id: Q5SLA8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

300852:TTH RS04430
gene id: 300852:TTH_RS04430
uniprot id: Q9WX76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

300852:TTH RS04455
gene id: 300852:TTH_RS04455
uniprot id: Q5SJZ0
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

300852:TTH RS00300
gene id: 300852:TTH_RS00300
uniprot id: Q5SM86
names: Similarity
messages: Belongs to the P(II) protein family.

300852:TTH RS07320
gene id: 300852:TTH_RS07320
uniprot id: Q5SIC8
names: Similarity
messages: Belongs to the FBPase class 2 family.

300852:TTH RS01355
gene id: 300852:TTH_RS01355
uniprot id: Q5SLN8
names: Similarity
messages: Belongs to the Fur family.

300852:TTH RS08260
gene id: 300852:TTH_RS08260
uniprot id: Q5SHU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

300852:TTH RS01040
gene id: 300852:TTH_RS01040
uniprot id: Q5SLU4
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

300852:TTH RS08570
gene id: 300852:TTH_RS08570
uniprot id: Q5SHN6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: EF-Tu-GDP binds to the acceptor arm of tmRNA by interacting with its acceptor arm, suggesting that GTP hydrolysis by EF-Tu is essential for tmRNA function.
messages: Monomer (By similarity). Binds to the 70S ribosome, contacts tmRNA during trans-translation (PubMed:12677067).
messages: Phosphorylated on a threonine.
messages: Protects glycyl-tRNA(Gly) from hydrolysis by E.coli D-aminoacyl-tRNA deacylase (dtd) (PubMed:27224426).
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

300852:TTH RS02030
gene id: 300852:TTH_RS02030
uniprot id: Q5SLA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

300852:TTH RS09995
gene id: 300852:TTH_RS09995
uniprot id: Q5SGW1
names: Similarity
messages: Belongs to the ParB family.

300852:TTH RS07515
gene id: 300852:TTH_RS07515
uniprot id: Q5SI90
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

300852:TTH RS02265
gene id: 300852:TTH_RS02265
uniprot id: Q5SL58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family. BdbC subfamily.
messages: Membrane

300852:TTH RS03995
gene id: 300852:TTH_RS03995
uniprot id: Q5SK78
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

300852:TTH RS02895
gene id: 300852:TTH_RS02895
uniprot id: Q5SKT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

300852:TTH RS06370
gene id: 300852:TTH_RS06370
uniprot id: Q5SIV8
names: Similarity
messages: Belongs to the UPF0145 family.

300852:TTH RS08580
gene id: 300852:TTH_RS08580
uniprot id: P17291
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 3'-end of the 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center. Binds mRNA and the E site tRNA blocking its exit path in the ribosome. This blockage implies that this section of the ribosome must be able to move to release the deacetylated tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. Binds to the C-terminus of IF3 and to the C-terminus of Era.

300852:TTH RS02910
gene id: 300852:TTH_RS02910
uniprot id: Q5SKT5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

300852:TTH RS01425
gene id: 300852:TTH_RS01425
uniprot id: Q5SLM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

300852:TTH RS10755
gene id: 300852:TTH_RS10755
uniprot id: Q53W19
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (Probable). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities (Probable).
messages: Encoded in a type III-A CRISPR locus.
messages: Probably part of the Csm effector complex, that includes Cas10, Csm2, Csm3, Csm4, Csm5 and mature crRNA.
messages: The N-terminal HD domain has ssDNase activity. The C-terminal GGDEF domain has the cOA synthesis activity.
messages: This subunit is a single-strand-specific deoxyribonuclease (ssDNase) which digests both linear and circular ssDNA; it has both exo- and endonuclease activity.
messages: When associated with the ternary Csm effector complex (the crRNA, Cas proteins and a cognate target ssRNA) synthesizes cyclic oligoadenylates (cOA) from ATP. The active cOA in this bacteria is cyclic tetraadenylate (cA4), presumably made by this enzyme. cOAs are second messengers that stimulate the ssRNase activity of Csm6, inducing an antiviral state important for defense against invading nucleic acids.
messages: ssDNase activity is stimulated in the ternary Csm effector complex; binding of cognate target RNA activates the ssDNase, as the target RNA is degraded ssDNA activity decreases.

300852:TTH RS00245
gene id: 300852:TTH_RS00245
uniprot id: Q56232
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the reversible conversion of aspartate and 2-oxoglutarate to glutamate and oxaloacetate (PubMed:8907187, PubMed:25070637). Can also transaminate prephenate in the presence of aspartate (PubMed:25070637, PubMed:30771275).
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS01230
gene id: 300852:TTH_RS01230
uniprot id: Q5SLQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

300852:TTH RS06200
gene id: 300852:TTH_RS06200
uniprot id: Q5SIZ2
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Periplasm

300852:TTH RS01265
gene id: 300852:TTH_RS01265
uniprot id: Q5SLQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA. Extends more that 50 Angstroms beyond the surface of the 70S ribosome.
messages: Part of the 50S ribosomal subunit.

300852:TTH RS01815
gene id: 300852:TTH_RS01815
uniprot id: Q5SLE8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

300852:TTH RS03155
gene id: 300852:TTH_RS03155
uniprot id: Q5SKN6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

300852:TTH RS09700
gene id: 300852:TTH_RS09700
uniprot id: Q5SH17
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

300852:TTH RS03485
gene id: 300852:TTH_RS03485
uniprot id: Q5SKH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

300852:TTH RS04295
gene id: 300852:TTH_RS04295
uniprot id: Q5SK21
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

300852:TTH RS07550
gene id: 300852:TTH_RS07550
uniprot id: Q56235
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock (By similarity).
messages: Cooperates with DnaJ, GrpE and ClpB to reactivate heat-inactivated proteins.
messages: Forms a heterononamer with DnaJ and DafA in the resting state. Three copies of each protein are present in the complex.
messages: In the resting state, the DnaK-DnaJ-DafA complex cannot bind substrate. As the substrate becomes sufficiently high, DafA is displaced and an active DnaK-substrate-DnaJ complex is formed.

300852:TTH RS08690
gene id: 300852:TTH_RS08690
uniprot id: Q5SHL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

300852:TTH RS10260
gene id: 300852:TTH_RS10260
uniprot id: Q53WA8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

300852:TTH RS02205
gene id: 300852:TTH_RS02205
uniprot id: Q5SL70
names: Similarity
messages: Belongs to the ComB family.

300852:TTH RS01905
gene id: 300852:TTH_RS01905
uniprot id: Q5SLC9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers (By similarity) (PubMed:29717025). Acts as a molecular motor to provide the energy that is required for biogenesis of the pilus and the extrusion of substrates generated in the cytoplasm (PubMed:27667690). PilB ATPase activity is also essential for T4P extension while antagonist PilT ATPase activity is required for T4P retraction (By similarity).
messages: Belongs to the GSP E family.
messages: Cytoplasm
messages: Homohexamer (PubMed:29717025, PubMed:27667690). Interacts with PilC (By similarity).
messages: The ATP-binding site is essential for assembly of pili.

300852:TTH RS10835
gene id: 300852:TTH_RS10835
uniprot id: Q53W05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CRISPR system Cmr5 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Part of the Cmr ribonucleoprotein complex (By similarity).
messages: Cytoplasm
messages: Homotrimer.

300852:TTH RS10230
gene id: 300852:TTH_RS10230
uniprot id: Q7SIC7
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

300852:TTH RS08530
gene id: 300852:TTH_RS08530
uniprot id: P80372
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

300852:TTH RS00915
gene id: 300852:TTH_RS00915
uniprot id: Q5SLW9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

300852:TTH RS04415
gene id: 300852:TTH_RS04415
uniprot id: Q5SJZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

300852:TTH RS05755
gene id: 300852:TTH_RS05755
uniprot id: P82543
names: Subcellular Location Annotation
messages: Cell membrane

300852:TTH RS11240
gene id: 300852:TTH_RS11240
uniprot id: Q53WI0
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Appears to be allosterically activated by NADH.
messages: Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
messages: Catalyzes the retro-aldol cleavage of both 4-hydroxy-2-oxopentanoate (HOPA) and 4-hydroxy-2-oxohexanoate (HOHA) to pyruvate and acetaldehyde or propanaldehyde, respectively. The aldehydes produced by this reaction are directly channeled to the dehydrogenase TTHB247, ensuring that these toxic aldehydes are sequestered from cellular components. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds. Appears to be stereospecific since it can cleave (4S)-4-hydroxy-2-oxopentanoate but not the (4R) isomer. Is not able to catalyze the aldol addition of 2-oxobutyrate with acetaldehyde; this indicates that the enzyme is specific for pyruvate as the carbonyl donor.
messages: Divalent metal cation. Has the highest activity with Co(2+) as cofactor, followed by Ni(2+) and Mn(2+). Mg(2+) and Ca(2+) are very poor metal cofactors.
messages: Homodimer. Can also form a heterotetramer composed of two aldolase (TTHB246) and two dehydrogenase (TTHB247) subunits. Upon complex formation, the aldolase shows a 5-fold increase in substrate affinity, while the dehydrogenase shows a 3-fold decrease; the kcat values of each enzyme are reduced by 2-fold when they are in a complex.

300852:TTH RS02815
gene id: 300852:TTH_RS02815
uniprot id: Q5SKV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PINc/VapC protein family.
messages: Membrane
messages: Part of a toxin-antitoxin (TA) system. An RNase.

300852:TTH RS04650
gene id: 300852:TTH_RS04650
uniprot id: Q8RR57
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Athough the Valle et al., electron microscopy paper indicates this protein came from T.thermophilus, its sequence maps to A.aeolicus (PubMed:12677067). The Fu et al., paper maps the coordinates of T.thermophilus to E.coli (PubMed:20940705).
messages: Belongs to the SmpB family.
messages: Binds tmRNA (PubMed:12677067, PubMed:20953161, PubMed:22422985, PubMed:17488812, PubMed:20940705, PubMed:22622583). Binds to both the 50S and 30S ribosomal subunits via rRNA contacts, bridges tmRNA binding to stalled ribosomes.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to tmRNA (also known as SsrA and 10Sa), required for stable association of tmRNA with ribosomes, probably by bridging tmRNA to 50S subunit. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB (PubMed:22422985, PubMed:17488812). tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

300852:TTH RS08995
gene id: 300852:TTH_RS08995
uniprot id: Q5SHF6
names: Similarity
messages: Belongs to the GSP E family.

300852:TTH RS09775
gene id: 300852:TTH_RS09775
uniprot id: Q5SH04
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

300852:TTH RS09275
gene id: 300852:TTH_RS09275
uniprot id: Q5SHA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

300852:TTH RS05475
gene id: 300852:TTH_RS05475
uniprot id: Q5SJD9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

300852:TTH RS05660
gene id: 300852:TTH_RS05660
uniprot id: Q5SJA1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.

300852:TTH RS07290
gene id: 300852:TTH_RS07290
uniprot id: Q56242
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

300852:TTH RS03205
gene id: 300852:TTH_RS03205
uniprot id: Q5SKM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

300852:TTH RS00900
gene id: 300852:TTH_RS00900
uniprot id: Q5SLX2
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

300852:TTH RS05345
gene id: 300852:TTH_RS05345
uniprot id: Q5SJF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

300852:TTH RS00015
gene id: 300852:TTH_RS00015
uniprot id: Q5SME0
names: Similarity
messages: Belongs to the pyruvate kinase family.

300852:TTH RS00475
gene id: 300852:TTH_RS00475
uniprot id: Q60019
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 15 different subunits, Nqo1 to Nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8 and Nqo10 to Nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9 and Nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP.

300852:TTH RS02640
gene id: 300852:TTH_RS02640
uniprot id: Q5SKY7
names: Similarity
messages: Belongs to the malate synthase family.

300852:TTH RS09000
gene id: 300852:TTH_RS09000
uniprot id: Q5SHF5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: PDB 1UFV apparently has a Val-49-Ala mutation.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

300852:TTH RS10075
gene id: 300852:TTH_RS10075
uniprot id: Q53WH7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

300852:TTH RS08575
gene id: 300852:TTH_RS08575
uniprot id: Q5SHN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

300852:TTH RS01060
gene id: 300852:TTH_RS01060
uniprot id: Q5SLU0
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS09200
gene id: 300852:TTH_RS09200
uniprot id: Q8RQE8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

300852:TTH RS09635
gene id: 300852:TTH_RS09635
uniprot id: Q5SH30
names: Similarity
messages: Belongs to the NAD synthetase family.

300852:TTH RS08515
gene id: 300852:TTH_RS08515
uniprot id: P0DOY7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: Increased generation time and a temperature-sensitive phenotype.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform and body of the 30S subunit by bringing together and stabilizing interactions between several different RNA helices. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S12.

300852:TTH RS07275
gene id: 300852:TTH_RS07275
uniprot id: Q5SID7
names: Disruption Phenotype
names: Function
names: Subunit
messages: Activates transcription. Positively regulates six promoters upstream of the TTHB186, TTHB147, TTHB178, TTHB159, TTHA0771 and TTHA0176 genes in a cAMP-dependent manner. Regulated genes include clustered regularly interspaced short palindromic repeat (CRISPR) associated (Cas) genes, and the genes encoding a putative transcriptional regulator, a protein containing the exonuclease III-like domain of DNA polymerase, a GCN5-related acetyltransferase homolog, and some T.thermophilus-specific proteins of unknown function. The consensus DNA-binding site of this transcriptional regulator is 5'-(CT)NNG(G/T)(G/T)C(A/C)N(A/T)NNTCACAN(G/C)(G/C)-3' in which N is G, A, T or C.
messages: Decreased expression of genes downstream of the TTHB186, TTHB147 and TTHB159 genes. Decreased expression of TTHB178, TTHA0771 and TTHA0176 genes.
messages: Homodimer.

300852:TTH RS03425
gene id: 300852:TTH_RS03425
uniprot id: Q5SKI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

300852:TTH RS02730
gene id: 300852:TTH_RS02730
uniprot id: Q5SKW9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H (By similarity). Monomer.

300852:TTH RS03260
gene id: 300852:TTH_RS03260
uniprot id: Q5SKL7
names: Function
names: Similarity
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.

300852:TTH RS07045
gene id: 300852:TTH_RS07045
uniprot id: Q5SIH8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

300852:TTH RS08685
gene id: 300852:TTH_RS08685
uniprot id: Q5SHL6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ChdC family. Type 1 subfamily.
messages: Fe-coproporphyrin III acts as both substrate and redox cofactor (By similarity). Was originally thought to use heme as a cofactor (PubMed:15965735).
messages: Homopentamer.
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate harderoheme intermediate (By similarity). When reconstituted with heme, can generate oxygen using chlorite or hydrogen peroxide as substrate (in vitro), but has very low affinity for hydrogen peroxide and chlorite and extremely low enzyme activity (PubMed:15965735).

300852:TTH RS06695
gene id: 300852:TTH_RS06695
uniprot id: Q5SIP7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Competitively inhibited by oxalate, a pyruvate enolate analog.
messages: Divalent metal cation. Has preference for nickel and cobalt ions for the HMG aldolase activity. Has preference for zinc ions for the OAA decarboxylase activity.
messages: Homotrimer.

300852:TTH RS07600
gene id: 300852:TTH_RS07600
uniprot id: Q5SI73
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS01800
gene id: 300852:TTH_RS01800
uniprot id: Q5SLF1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

300852:TTH RS00130
gene id: 300852:TTH_RS00130
uniprot id: Q5SMC0
names: Similarity
messages: Belongs to the peptidase S16 family.

300852:TTH RS06665
gene id: 300852:TTH_RS06665
uniprot id: Q5SIQ3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

300852:TTH RS03730
gene id: 300852:TTH_RS03730
uniprot id: Q5SKC5
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.
messages: Monomer.
messages: Product-inhibited by apurinic/apyrimidinic sites.
messages: Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G, U/A, U/C or U/T base pair as well as from single-stranded DNA (PubMed:12000829, PubMed:14556741). Specifically recognizes uracil that is flipped out from double-stranded DNA (PubMed:14556741).
messages: The 4Fe-4S cluster may have a structural rather than a catalytic role. Does not appear to be essential for enzyme activity.

300852:TTH RS03725
gene id: 300852:TTH_RS03725
uniprot id: Q5SKC6
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

300852:TTH RS00675
gene id: 300852:TTH_RS00675
uniprot id: Q5SM15
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

300852:TTH RS09060
gene id: 300852:TTH_RS09060
uniprot id: Q5SHE5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

300852:TTH RS08030
gene id: 300852:TTH_RS08030
uniprot id: Q5SHZ4
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner (PubMed:23804759, PubMed:11850422). It probably also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes (PubMed:11850422). Relaxes negatively supercoiled DNA in an ATP-independent manner (PubMed:23804759, PubMed:11850422). At comparable concentrations T.thermophilus gyrase does not introduce as many negative supercoils into DNA as the E.coli enzyme (PubMed:23804759).
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Consists of 3 domains; the ATPase domain (residues 1-220), the transducer domain (221-390) and the toprim domain (391-634) (PubMed:11850422). Removal of the N-terminal ATPase domain (residues 2-392) increases ATP-independent DNA relaxation, showing it is not required for DNA binding or cleavage, this enzyme still has some supercoiling activity, but in this case it introduces positive supercoils (PubMed:23804759).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: For the electron microscopy studies a GyrB-GyrA fusion protein was made with a Gly-Asp-Leu linker between the 2 subunits. It forms the expected dimer (PubMed:23804759).
messages: Heterotetramer, composed of two GyrA and two GyrB chains (PubMed:23804759). Non-hydrolyzable ATP analogs induce dimerization, novobiocin also induces a small amount of dimerization (PubMed:11850422). The two subunits form an intertwined dimer where the GyrB ATPase transducer helix of 1 subunit connects to the Toprim domain of the other GyrB subunit through a 10 residue linker (PubMed:23804759). In the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.
messages: Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

300852:TTH RS10780
gene id: 300852:TTH_RS10780
uniprot id: Q53W17
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single-strand-specific endoribonuclease (ssRNase) producing free 5'-OH (PubMed:26763118). Activity is approximately 1000-fold stimulated by cyclic oligoadenylate (cOA); only cyclic tetraadenylate (cA4) stimulates the ssRNase activity while linear oligoadenylates do not activate the RNase (PubMed:28663439). Another study showed stimulation by linear tetraadenylate at very high concentrations, but did not examine stimulation by cA4 (PubMed:28722012).
messages: Belongs to the CRISPR-associated Csm6 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (Probable). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities. This protein is not part of the Csm effector complex (Probable).
messages: Does not require a metal cofactor.
messages: Homodimer. The protein forms a twisted, head-to-head dimer; the composite ssRNase active site is formed at the dimer interface.
messages: Non-specific ssRNase activity is allosterically activated about 1000-fold by cyclic tetraadenylate (cA4), which probably binds to its CARF domain.
messages: Probably encoded in a type III-A CRISPR locus.
messages: The N-terminal CRISPR-associated Rossman fold (CARF) probably binds the cA4 effector. ssRNase activity resides in the C-terminal HEPN domain.

300852:TTH RS07185
gene id: 300852:TTH_RS07185
uniprot id: Q5SME7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SoxA family.
messages: Binds 2 heme groups per subunit.
messages: Heterodimer of SoxA and SoxX.
messages: Periplasm

300852:TTH RS02155
gene id: 300852:TTH_RS02155
uniprot id: Q5SL80
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

300852:TTH RS09610
gene id: 300852:TTH_RS09610
uniprot id: Q56213
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS08255
gene id: 300852:TTH_RS08255
uniprot id: Q5SHU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.

300852:TTH RS08615
gene id: 300852:TTH_RS08615
uniprot id: Q5SHM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

300852:TTH RS01535
gene id: 300852:TTH_RS01535
uniprot id: Q9F1Q3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

300852:TTH RS09670
gene id: 300852:TTH_RS09670
uniprot id: Q5SH23
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RimK family. LysX subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the ATP-dependent formation of a covalent bond between the amino group of alpha-aminoadipate (AAA) and the gamma-carboxyl group of the C-terminal glutamate residue in LysW.
messages: Homodimer.

300852:TTH RS04965
gene id: 300852:TTH_RS04965
uniprot id: Q5SJN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

300852:TTH RS04565
gene id: 300852:TTH_RS04565
uniprot id: Q5SJW6
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

300852:TTH RS03040
gene id: 300852:TTH_RS03040
uniprot id: Q5SKQ8
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS04110
gene id: 300852:TTH_RS04110
uniprot id: Q5SK58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Essential inner membrane component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers. Controls both pilus assembly and disassembly and plays an important role in PilB localization to the complex and ATPase activity.
messages: Homotetramer (PubMed:20455262). Interacts with PilB (By similarity).

300852:TTH RS06845
gene id: 300852:TTH_RS06845
uniprot id: Q5SIL6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

300852:TTH RS03680
gene id: 300852:TTH_RS03680
uniprot id: Q5SKD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

300852:TTH RS09215
gene id: 300852:TTH_RS09215
uniprot id: Q5SHB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

300852:TTH RS07855
gene id: 300852:TTH_RS07855
uniprot id: Q5SI29
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

300852:TTH RS08440
gene id: 300852:TTH_RS08440
uniprot id: Q5SHR2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL36 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 50S ribosomal subunit.

300852:TTH RS07920
gene id: 300852:TTH_RS07920
uniprot id: Q5SI16
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MGMT family. ATL subfamily.
messages: Disruption increases the spontaneous mutation rate.
messages: Interacts with several proteins, including UvrA, UvrD and the three subunits of the RNA polymerase.
messages: Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine and larger O(6)-alkylguanine adducts (PubMed:18483064, PubMed:23112169). Binds to the damaged base and flips the base out of the DNA duplex into an extrahelical conformation, which allows processing by repair proteins (PubMed:18483064). Also affects the regulation of gene expression in response to alkylation (PubMed:21531768).

300852:TTH RS00720
gene id: 300852:TTH_RS00720
uniprot id: Q5SM07
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

300852:TTH RS02250
gene id: 300852:TTH_RS02250
uniprot id: Q5SL61
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

300852:TTH RS00075
gene id: 300852:TTH_RS00075
uniprot id: Q5SMD0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

300852:TTH RS00230
gene id: 300852:TTH_RS00230
uniprot id: Q5SMA0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

300852:TTH RS01275
gene id: 300852:TTH_RS01275
uniprot id: Q5SLP9
names: Function
names: Subunit
messages: Homodimer.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

300852:TTH RS03565
gene id: 300852:TTH_RS03565
uniprot id: Q5SKF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

300852:TTH RS04240
gene id: 300852:TTH_RS04240
uniprot id: Q5SK31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

300852:TTH RS07355
gene id: 300852:TTH_RS07355
uniprot id: Q5SIC1
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

300852:TTH RS09035
gene id: 300852:TTH_RS09035
uniprot id: P60493
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL27 family.
messages: Found on the solvent side of the large subunit.
messages: Part of the 50S ribosomal subunit.

300852:TTH RS00670
gene id: 300852:TTH_RS00670
uniprot id: Q5SM16
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Binding of TrmH to tRNA is composed of at least three steps: the first is bi-molecular binding and the subsequent two are uni-molecular induced-fit processes.
messages: Both N- and C-terminal regions function in tRNA binding, but the substrate tRNA is determined by the catalytic domain.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA. Type I methylase, which methylates all tRNAs.
messages: Homodimer.

300852:TTH RS05275
gene id: 300852:TTH_RS05275
uniprot id: Q5SJH2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

300852:TTH RS08020
gene id: 300852:TTH_RS08020
uniprot id: P29748
names: Function
messages: A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-TCGA-3' and cleaves after T-1.

300852:TTH RS05265
gene id: 300852:TTH_RS05265
uniprot id: Q5SJH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

300852:TTH RS07570
gene id: 300852:TTH_RS07570
uniprot id: Q5SI79
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS07125
gene id: 300852:TTH_RS07125
uniprot id: Q5SIG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Membrane

300852:TTH RS00470
gene id: 300852:TTH_RS00470
uniprot id: Q56223
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit. The [2Fe-2S] cluster 1 is referred to as N1b.
messages: Binds 3 [4Fe-4S] clusters per subunit. The [4Fe-4S] clusters 2, 3, and 4 are referred to as N5, N4, and N7, respectively. The [4Fe-4S] cluster 4 is too far away from the main redox chain to participate in electron transfer but probably confers structural stability.
messages: Cell membrane
messages: NDH-1 is composed of 15 different subunits, Nqo1 to Nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8 and Nqo10 to Nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9 and Nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP.
messages: The subunit comprises two main parts, an N-terminal [FeFe]-hydrogenase-like domain (residues 1 to 240) that coordinates clusters 1, 2 and 3, and a domain similar to molybdopterin-containing enzymes (residues 241 to 767) whose first subdomain coordinates cluster 4.

300852:TTH RS10350
gene id: 300852:TTH_RS10350
uniprot id: Q53W90
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

300852:TTH RS05560
gene id: 300852:TTH_RS05560
uniprot id: Q5SJC2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

300852:TTH RS06455
gene id: 300852:TTH_RS06455
uniprot id: Q56403
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

300852:TTH RS00400
gene id: 300852:TTH_RS00400
uniprot id: Q5SM66
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

300852:TTH RS05375
gene id: 300852:TTH_RS05375
uniprot id: Q5SMH2
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

300852:TTH RS05850
gene id: 300852:TTH_RS05850
uniprot id: P42778
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M29 family.
messages: Binds 2 divalent metal cations per subunit. Can use cobalt, zinc, and possibly also magnesium ions.
messages: Homodimer.
messages: Metal-dependent exopeptidase.

300852:TTH RS00985
gene id: 300852:TTH_RS00985
uniprot id: Q5SLV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

300852:TTH RS02080
gene id: 300852:TTH_RS02080
uniprot id: Q5SL95
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS01770
gene id: 300852:TTH_RS01770
uniprot id: Q5SLF7
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

300852:TTH RS04425
gene id: 300852:TTH_RS04425
uniprot id: Q5SJZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

300852:TTH RS02120
gene id: 300852:TTH_RS02120
uniprot id: Q5SL87
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvB is a Mg(2+)-dependent, DNA-dependent ATPase with an equal preference for supercoiled and linear duplex DNA. It can promote Holliday junction migration alone.
messages: The activity of RuvB is enhanced by RuvA.

300852:TTH RS01810
gene id: 300852:TTH_RS01810
uniprot id: Q5SLE9
names: Similarity
messages: Belongs to the Fur family.

300852:TTH RS10005
gene id: 300852:TTH_RS10005
uniprot id: Q9LCY2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Low-level streptomycin resistance.
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. Shows a marked preference for deproteinized 16S rRNA as substrate and is completely inactive with native 30S subunits as substrate.

300852:TTH RS00975
gene id: 300852:TTH_RS00975
uniprot id: Q5SLV7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

300852:TTH RS01390
gene id: 300852:TTH_RS01390
uniprot id: Q5SLN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

300852:TTH RS06700
gene id: 300852:TTH_RS06700
uniprot id: Q9RA54
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

300852:TTH RS08680
gene id: 300852:TTH_RS08680
uniprot id: Q5SHL7
names: Similarity
messages: Belongs to the UPF0047 family.

300852:TTH RS06505
gene id: 300852:TTH_RS06505
uniprot id: Q5SIT1
names: Similarity
messages: Belongs to the UPF0173 family.

300852:TTH RS10765
gene id: 300852:TTH_RS10765
uniprot id: Q53WF5
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

300852:TTH RS07555
gene id: 300852:TTH_RS07555
uniprot id: Q5SI82
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Degrades preferentially unfolded substrates in a processive, ATP-dependent manner, usually after hydrophobic residues.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: The isolated soluble domain (residues 126-624) forms a stable hexamer in which the AAA+ domains (residues 126-400) are alternatively open or closed.
messages: The open AAA+ domain (residues 126-400) probably allows nucleotide exchange and has the protease active site, while the closed domain is the active ATPase domain but the protease is inactive.
messages: The proteolytic activity is dependent on ATP, both the ATPase and protease activities are inhibited by ADP.

300852:TTH RS03595
gene id: 300852:TTH_RS03595
uniprot id: Q5SKF2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

300852:TTH RS03450
gene id: 300852:TTH_RS03450
uniprot id: Q5SKI2
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS01280
gene id: 300852:TTH_RS01280
uniprot id: Q5SLP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Located on the outer edge of the platform on the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S18. May make transient contacts with protein L2 of the 50S subunit during translation.

300852:TTH RS01370
gene id: 300852:TTH_RS01370
uniprot id: Q5SLN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm

300852:TTH RS09340
gene id: 300852:TTH_RS09340
uniprot id: Q5SH90
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

300852:TTH RS07085
gene id: 300852:TTH_RS07085
uniprot id: Q5SIH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

300852:TTH RS01400
gene id: 300852:TTH_RS01400
uniprot id: Q5SLM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

300852:TTH RS00965
gene id: 300852:TTH_RS00965
uniprot id: Q5SLV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

300852:TTH RS09805
gene id: 300852:TTH_RS09805
uniprot id: Q5SH00
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS02800
gene id: 300852:TTH_RS02800
uniprot id: Q5SKV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

300852:TTH RS01185
gene id: 300852:TTH_RS01185
uniprot id: Q5SLR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

300852:TTH RS04665
gene id: 300852:TTH_RS04665
uniprot id: Q5SMF8
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

300852:TTH RS08455
gene id: 300852:TTH_RS08455
uniprot id: Q5SHQ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

300852:TTH RS00970
gene id: 300852:TTH_RS00970
uniprot id: Q5SLV8
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

300852:TTH RS05650
gene id: 300852:TTH_RS05650
uniprot id: Q5SJA3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

300852:TTH RS07805
gene id: 300852:TTH_RS07805
uniprot id: Q5SI38
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity).
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

300852:TTH RS09170
gene id: 300852:TTH_RS09170
uniprot id: O50606
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
messages: Monomer.

300852:TTH RS08470
gene id: 300852:TTH_RS08470
uniprot id: Q5SHQ6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

300852:TTH RS08130
gene id: 300852:TTH_RS08130
uniprot id: Q5SHX4
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

300852:TTH RS04585
gene id: 300852:TTH_RS04585
uniprot id: Q5SJW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

300852:TTH RS10870
gene id: 300852:TTH_RS10870
uniprot id: Q53VZ7
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

300852:TTH RS09350
gene id: 300852:TTH_RS09350
uniprot id: Q5SH88
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

300852:TTH RS05295
gene id: 300852:TTH_RS05295
uniprot id: Q5SJG8
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS07115
gene id: 300852:TTH_RS07115
uniprot id: Q5SIG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell inner membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

300852:TTH RS08420
gene id: 300852:TTH_RS08420
uniprot id: Q5SHR6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription (By similarity).
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

300852:TTH RS04510
gene id: 300852:TTH_RS04510
uniprot id: Q5SJX8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Acts as a N-succinylamino acid racemase (NSAR) that catalyzes the racemization of N-succinyl-L-phenylglycine (PubMed:24872444). Also converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:24872444). Catalyzes both N-succinylamino acid racemization and OSB synthesis at equivalent rates (PubMed:24872444). However, NSAR activity is probably the protein's biological function, because menaquinone biosynthesis genes are missing in this species (Probable).
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.
messages: Binds 1 divalent metal cation per subunit.
messages: Homooctamer. Tetramer of dimers.

300852:TTH RS05695
gene id: 300852:TTH_RS05695
uniprot id: Q5SJ94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

300852:TTH RS00395
gene id: 300852:TTH_RS00395
uniprot id: Q5SM67
names: Similarity
messages: Belongs to the TrpF family.

300852:TTH RS08155
gene id: 300852:TTH_RS08155
uniprot id: Q5SHW9
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

300852:TTH RS06725
gene id: 300852:TTH_RS06725
uniprot id: Q5SIP1
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

300852:TTH RS04135
gene id: 300852:TTH_RS04135
uniprot id: Q5SK53
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

300852:TTH RS03410
gene id: 300852:TTH_RS03410
uniprot id: Q5SKI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

300852:TTH RS03525
gene id: 300852:TTH_RS03525
uniprot id: Q5SKG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

300852:TTH RS01100
gene id: 300852:TTH_RS01100
uniprot id: Q5SLT2
names: Subcellular Location Annotation
messages: Membrane

300852:TTH RS07770
gene id: 300852:TTH_RS07770
uniprot id: P33197
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Homodimer.