292459:STH RS12470
gene id: 292459:STH_RS12470
uniprot id: Q67LF4
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS08290
gene id: 292459:STH_RS08290
uniprot id: Q67NW3
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

292459:STH RS15205
gene id: 292459:STH_RS15205
uniprot id: Q67JV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

292459:STH RS07575
gene id: 292459:STH_RS07575
uniprot id: Q67PA7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

292459:STH RS02610
gene id: 292459:STH_RS02610
uniprot id: Q67S55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

292459:STH RS02010
gene id: 292459:STH_RS02010
uniprot id: Q67SH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS05290
gene id: 292459:STH_RS05290
uniprot id: Q67QM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

292459:STH RS05810
gene id: 292459:STH_RS05810
uniprot id: Q67QC1
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

292459:STH RS08130
gene id: 292459:STH_RS08130
uniprot id: Q67NZ6
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

292459:STH RS00645
gene id: 292459:STH_RS00645
uniprot id: Q67T87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

292459:STH RS09260
gene id: 292459:STH_RS09260
uniprot id: Q67NB6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

292459:STH RS04015
gene id: 292459:STH_RS04015
uniprot id: Q67RD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

292459:STH RS08575
gene id: 292459:STH_RS08575
uniprot id: Q67NQ5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.

292459:STH RS17680
gene id: 292459:STH_RS17680
uniprot id: Q67QH7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

292459:STH RS00210
gene id: 292459:STH_RS00210
uniprot id: Q67TI1
names: Similarity
messages: Belongs to the OsmC/Ohr family.

292459:STH RS07425
gene id: 292459:STH_RS07425
uniprot id: Q67PD7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

292459:STH RS00795
gene id: 292459:STH_RS00795
uniprot id: Q67T57
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

292459:STH RS15165
gene id: 292459:STH_RS15165
uniprot id: Q67JW7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

292459:STH RS08770
gene id: 292459:STH_RS08770
uniprot id: Q67NL6
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS09650
gene id: 292459:STH_RS09650
uniprot id: Q67N37
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

292459:STH RS02855
gene id: 292459:STH_RS02855
uniprot id: Q67S06
names: Similarity
messages: Belongs to the phosphopentomutase family.

292459:STH RS00080
gene id: 292459:STH_RS00080
uniprot id: Q67TJ3
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

292459:STH RS06100
gene id: 292459:STH_RS06100
uniprot id: Q67Q62
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

292459:STH RS11935
gene id: 292459:STH_RS11935
uniprot id: Q67LR7
names: Similarity
messages: Belongs to the universal stress protein A family.

292459:STH RS15210
gene id: 292459:STH_RS15210
uniprot id: Q67JV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

292459:STH RS12170
gene id: 292459:STH_RS12170
uniprot id: Q67LL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

292459:STH RS15990
gene id: 292459:STH_RS15990
uniprot id: Q67JF3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

292459:STH RS01245
gene id: 292459:STH_RS01245
uniprot id: Q67SW6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

292459:STH RS04920
gene id: 292459:STH_RS04920
uniprot id: Q67QU8
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

292459:STH RS15845
gene id: 292459:STH_RS15845
uniprot id: Q67JI1
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

292459:STH RS05650
gene id: 292459:STH_RS05650
uniprot id: Q67QF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS00775
gene id: 292459:STH_RS00775
uniprot id: Q67T61
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

292459:STH RS15235
gene id: 292459:STH_RS15235
uniprot id: Q67JV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

292459:STH RS12120
gene id: 292459:STH_RS12120
uniprot id: Q67LM6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

292459:STH RS07865
gene id: 292459:STH_RS07865
uniprot id: Q67P48
names: Similarity
messages: Belongs to the Fur family.

292459:STH RS07025
gene id: 292459:STH_RS07025
uniprot id: Q67PM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

292459:STH RS11840
gene id: 292459:STH_RS11840
uniprot id: Q67LT6
names: Similarity
messages: Belongs to the peptidase S11 family.

292459:STH RS17565
gene id: 292459:STH_RS17565
uniprot id: Q67KB3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

292459:STH RS16115
gene id: 292459:STH_RS16115
uniprot id: Q67JC8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

292459:STH RS10810
gene id: 292459:STH_RS10810
uniprot id: Q67MF3
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

292459:STH RS12060
gene id: 292459:STH_RS12060
uniprot id: Q67LN8
names: Similarity
messages: Belongs to the peptidase S51 family.

292459:STH RS05920
gene id: 292459:STH_RS05920
uniprot id: Q67Q97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

292459:STH RS16515
gene id: 292459:STH_RS16515
uniprot id: Q67J55
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

292459:STH RS06365
gene id: 292459:STH_RS06365
uniprot id: Q67Q10
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS08630
gene id: 292459:STH_RS08630
uniprot id: Q67NP4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

292459:STH RS02540
gene id: 292459:STH_RS02540
uniprot id: Q67S69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS00875
gene id: 292459:STH_RS00875
uniprot id: Q67T41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

292459:STH RS05410
gene id: 292459:STH_RS05410
uniprot id: Q67QJ8
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

292459:STH RS07165
gene id: 292459:STH_RS07165
uniprot id: Q67PJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

292459:STH RS15825
gene id: 292459:STH_RS15825
uniprot id: Q67JI5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

292459:STH RS00895
gene id: 292459:STH_RS00895
uniprot id: Q67T37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

292459:STH RS10885
gene id: 292459:STH_RS10885
uniprot id: Q67MD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAE transporter (TC 2.A.81) family.
messages: Cell membrane

292459:STH RS13280
gene id: 292459:STH_RS13280
uniprot id: Q67KY9
names: Similarity
messages: Belongs to the OsmC/Ohr family.

292459:STH RS14145
gene id: 292459:STH_RS14145
uniprot id: Q08897
names: Similarity
names: Subunit
messages: Belongs to the beta-eliminating lyase family.
messages: Homotetramer.

292459:STH RS07480
gene id: 292459:STH_RS07480
uniprot id: Q67PC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

292459:STH RS00570
gene id: 292459:STH_RS00570
uniprot id: Q67TA3
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

292459:STH RS15745
gene id: 292459:STH_RS15745
uniprot id: Q67JK1
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

292459:STH RS06155
gene id: 292459:STH_RS06155
uniprot id: Q67Q52
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

292459:STH RS15305
gene id: 292459:STH_RS15305
uniprot id: Q67JT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

292459:STH RS01900
gene id: 292459:STH_RS01900
uniprot id: Q67SJ7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

292459:STH RS04170
gene id: 292459:STH_RS04170
uniprot id: Q67RA4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

292459:STH RS08670
gene id: 292459:STH_RS08670
uniprot id: Q67NN6
names: Function
names: Similarity
messages: Belongs to the peptidase S51 family.
messages: Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.

292459:STH RS16545
gene id: 292459:STH_RS16545
uniprot id: Q67J49
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

292459:STH RS06670
gene id: 292459:STH_RS06670
uniprot id: Q67PU4
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

292459:STH RS05765
gene id: 292459:STH_RS05765
uniprot id: Q67QD4
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS07680
gene id: 292459:STH_RS07680
uniprot id: Q67P85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

292459:STH RS07190
gene id: 292459:STH_RS07190
uniprot id: Q67PI7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

292459:STH RS07725
gene id: 292459:STH_RS07725
uniprot id: Q67P76
names: Similarity
messages: Belongs to the peptidase M16 family.

292459:STH RS04080
gene id: 292459:STH_RS04080
uniprot id: Q67RC3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

292459:STH RS09510
gene id: 292459:STH_RS09510
uniprot id: Q67N65
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

292459:STH RS00670
gene id: 292459:STH_RS00670
uniprot id: Q67T82
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

292459:STH RS00665
gene id: 292459:STH_RS00665
uniprot id: Q67T83
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: May bind 1 zinc ion per subunit.
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

292459:STH RS00045
gene id: 292459:STH_RS00045
uniprot id: Q67TJ9
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

292459:STH RS12465
gene id: 292459:STH_RS12465
uniprot id: Q67LF5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS14335
gene id: 292459:STH_RS14335
uniprot id: Q67KD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

292459:STH RS03770
gene id: 292459:STH_RS03770
uniprot id: Q67RH1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

292459:STH RS12415
gene id: 292459:STH_RS12415
uniprot id: Q67LG5
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

292459:STH RS02710
gene id: 292459:STH_RS02710
uniprot id: Q67S35
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

292459:STH RS00700
gene id: 292459:STH_RS00700
uniprot id: Q67T76
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

292459:STH RS01180
gene id: 292459:STH_RS01180
uniprot id: Q67SX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

292459:STH RS08280
gene id: 292459:STH_RS08280
uniprot id: Q67NW5
names: Similarity
messages: Belongs to the CinA family.

292459:STH RS05750
gene id: 292459:STH_RS05750
uniprot id: Q67QD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

292459:STH RS08415
gene id: 292459:STH_RS08415
uniprot id: Q67R61
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS07690
gene id: 292459:STH_RS07690
uniprot id: Q67P83
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

292459:STH RS04705
gene id: 292459:STH_RS04705
uniprot id: Q67QZ1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the nitrate reductase NapAB complex composed of NapA and NapB.
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.
messages: Secreted

292459:STH RS07955
gene id: 292459:STH_RS07955
uniprot id: Q67P31
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

292459:STH RS04725
gene id: 292459:STH_RS04725
uniprot id: Q67QY7
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS07155
gene id: 292459:STH_RS07155
uniprot id: Q67PJ5
names: Similarity
messages: Belongs to the TrpF family.

292459:STH RS05615
gene id: 292459:STH_RS05615
uniprot id: Q67QF8
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS07660
gene id: 292459:STH_RS07660
uniprot id: Q67P89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

292459:STH RS07625
gene id: 292459:STH_RS07625
uniprot id: Q67P96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

292459:STH RS02160
gene id: 292459:STH_RS02160
uniprot id: Q67SE5
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

292459:STH RS04685
gene id: 292459:STH_RS04685
uniprot id: Q67QZ5
names: Similarity
messages: Belongs to the peptidase M16 family.

292459:STH RS06550
gene id: 292459:STH_RS06550
uniprot id: Q67PX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

292459:STH RS07550
gene id: 292459:STH_RS07550
uniprot id: Q67PB2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

292459:STH RS12605
gene id: 292459:STH_RS12605
uniprot id: Q67LC7
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

292459:STH RS14860
gene id: 292459:STH_RS14860
uniprot id: Q3V817
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliR/MopE/SpaR family.
messages: Membrane

292459:STH RS04195
gene id: 292459:STH_RS04195
uniprot id: Q67R98
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

292459:STH RS15220
gene id: 292459:STH_RS15220
uniprot id: Q67JV6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

292459:STH RS14855
gene id: 292459:STH_RS14855
uniprot id: Q67K27
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

292459:STH RS09430
gene id: 292459:STH_RS09430
uniprot id: Q67N82
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

292459:STH RS09390
gene id: 292459:STH_RS09390
uniprot id: Q67N90
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS08030
gene id: 292459:STH_RS08030
uniprot id: Q67P16
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

292459:STH RS01905
gene id: 292459:STH_RS01905
uniprot id: Q67SJ6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

292459:STH RS08490
gene id: 292459:STH_RS08490
uniprot id: Q67NS2
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

292459:STH RS01025
gene id: 292459:STH_RS01025
uniprot id: Q67T10
names: Similarity
messages: Belongs to the glutamine synthetase family.

292459:STH RS09910
gene id: 292459:STH_RS09910
uniprot id: Q67MY2
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

292459:STH RS02720
gene id: 292459:STH_RS02720
uniprot id: Q67S33
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

292459:STH RS15690
gene id: 292459:STH_RS15690
uniprot id: Q67JL1
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

292459:STH RS13305
gene id: 292459:STH_RS13305
uniprot id: Q67KY4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

292459:STH RS15195
gene id: 292459:STH_RS15195
uniprot id: Q67JW1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

292459:STH RS06210
gene id: 292459:STH_RS06210
uniprot id: Q67Q41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sbp family.
messages: Cell membrane

292459:STH RS07430
gene id: 292459:STH_RS07430
uniprot id: Q67PD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

292459:STH RS14050
gene id: 292459:STH_RS14050
uniprot id: Q67KI8
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

292459:STH RS15070
gene id: 292459:STH_RS15070
uniprot id: Q67JY5
names: Similarity
messages: Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family.

292459:STH RS07805
gene id: 292459:STH_RS07805
uniprot id: Q67P60
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

292459:STH RS14965
gene id: 292459:STH_RS14965
uniprot id: Q67K07
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

292459:STH RS08285
gene id: 292459:STH_RS08285
uniprot id: Q67NW4
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.
messages: Transcriptional repressor of xylose-utilizing enzymes.

292459:STH RS07090
gene id: 292459:STH_RS07090
uniprot id: Q67PK8
names: Caution
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

292459:STH RS09730
gene id: 292459:STH_RS09730
uniprot id: Q67N21
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

292459:STH RS06415
gene id: 292459:STH_RS06415
uniprot id: Q67Q00
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

292459:STH RS05175
gene id: 292459:STH_RS05175
uniprot id: Q67QP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

292459:STH RS02075
gene id: 292459:STH_RS02075
uniprot id: Q67SG2
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS03610
gene id: 292459:STH_RS03610
uniprot id: Q67RK3
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS10610
gene id: 292459:STH_RS10610
uniprot id: Q67MJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

292459:STH RS12250
gene id: 292459:STH_RS12250
uniprot id: Q67LJ8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

292459:STH RS09370
gene id: 292459:STH_RS09370
uniprot id: Q67N94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

292459:STH RS13780
gene id: 292459:STH_RS13780
uniprot id: Q67KP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
messages: Membrane

292459:STH RS05510
gene id: 292459:STH_RS05510
uniprot id: Q67QH9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

292459:STH RS02935
gene id: 292459:STH_RS02935
uniprot id: Q67RZ0
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

292459:STH RS16130
gene id: 292459:STH_RS16130
uniprot id: Q67JC5
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

292459:STH RS13140
gene id: 292459:STH_RS13140
uniprot id: Q67L19
names: Similarity
messages: Belongs to the class-I fumarase family.

292459:STH RS13325
gene id: 292459:STH_RS13325
uniprot id: Q67KY0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

292459:STH RS04215
gene id: 292459:STH_RS04215
uniprot id: Q67R92
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.

292459:STH RS07400
gene id: 292459:STH_RS07400
uniprot id: Q67PE2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

292459:STH RS01195
gene id: 292459:STH_RS01195
uniprot id: Q67SX6
names: Similarity
messages: Belongs to the asp23 family.

292459:STH RS15150
gene id: 292459:STH_RS15150
uniprot id: Q67JX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

292459:STH RS16295
gene id: 292459:STH_RS16295
uniprot id: Q67J97
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

292459:STH RS08350
gene id: 292459:STH_RS08350
uniprot id: Q67NV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.
messages: Membrane

292459:STH RS08040
gene id: 292459:STH_RS08040
uniprot id: Q67P14
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

292459:STH RS08420
gene id: 292459:STH_RS08420
uniprot id: Q67NT6
names: Similarity
messages: Belongs to the type IA topoisomerase family.

292459:STH RS00005
gene id: 292459:STH_RS00005
uniprot id: Q67TK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

292459:STH RS09295
gene id: 292459:STH_RS09295
uniprot id: Q67NA9
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

292459:STH RS00495
gene id: 292459:STH_RS00495
uniprot id: Q67TB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

292459:STH RS01215
gene id: 292459:STH_RS01215
uniprot id: Q67SX2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

292459:STH RS02260
gene id: 292459:STH_RS02260
uniprot id: Q67SC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

292459:STH RS03355
gene id: 292459:STH_RS03355
uniprot id: Q67RQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

292459:STH RS08495
gene id: 292459:STH_RS08495
uniprot id: Q67NS1
names: Similarity
messages: Belongs to the DinB family.

292459:STH RS04735
gene id: 292459:STH_RS04735
uniprot id: Q67QY5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS06390
gene id: 292459:STH_RS06390
uniprot id: Q67Q05
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

292459:STH RS01880
gene id: 292459:STH_RS01880
uniprot id: Q67SK1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

292459:STH RS19160
gene id: 292459:STH_RS19160
uniprot id: Q67N17
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS15065
gene id: 292459:STH_RS15065
uniprot id: Q67JY6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

292459:STH RS00060
gene id: 292459:STH_RS00060
uniprot id: Q67TJ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

292459:STH RS00485
gene id: 292459:STH_RS00485
uniprot id: Q67TC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

292459:STH RS10825
gene id: 292459:STH_RS10825
uniprot id: Q67MF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

292459:STH RS02150
gene id: 292459:STH_RS02150
uniprot id: Q67SE7
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

292459:STH RS16595
gene id: 292459:STH_RS16595
uniprot id: Q67J37
names: Similarity
messages: Belongs to the ParB family.

292459:STH RS00690
gene id: 292459:STH_RS00690
uniprot id: Q67T78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS16885
gene id: 292459:STH_RS16885
uniprot id: Q67RL5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

292459:STH RS16840
gene id: 292459:STH_RS16840
uniprot id: Q67RT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

292459:STH RS13810
gene id: 292459:STH_RS13810
uniprot id: Q67KN8
names: Function
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

292459:STH RS06125
gene id: 292459:STH_RS06125
uniprot id: Q67Q57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

292459:STH RS16875
gene id: 292459:STH_RS16875
uniprot id: Q67RM0
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS08270
gene id: 292459:STH_RS08270
uniprot id: Q67NW7
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

292459:STH RS12225
gene id: 292459:STH_RS12225
uniprot id: Q67LK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TatA/E family.
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

292459:STH RS01280
gene id: 292459:STH_RS01280
uniprot id: Q67SV9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

292459:STH RS13335
gene id: 292459:STH_RS13335
uniprot id: Q67KX8
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

292459:STH RS13990
gene id: 292459:STH_RS13990
uniprot id: Q67KK0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.

292459:STH RS07250
gene id: 292459:STH_RS07250
uniprot id: Q67PH5
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.
messages: Belongs to the peptidase A25 family.
messages: Homotetramer.
messages: Initiates the rapid degradation of small, acid-soluble proteins during spore germination.

292459:STH RS10525
gene id: 292459:STH_RS10525
uniprot id: Q67ML0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

292459:STH RS08345
gene id: 292459:STH_RS08345
uniprot id: Q67NV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit C family.
messages: Membrane

292459:STH RS15510
gene id: 292459:STH_RS15510
uniprot id: Q67R61
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS03340
gene id: 292459:STH_RS03340
uniprot id: Q67RQ9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS10010
gene id: 292459:STH_RS10010
uniprot id: Q67MW5
names: Similarity
messages: Belongs to the UPF0473 family.

292459:STH RS05915
gene id: 292459:STH_RS05915
uniprot id: Q67Q98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

292459:STH RS15280
gene id: 292459:STH_RS15280
uniprot id: Q67JU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

292459:STH RS16390
gene id: 292459:STH_RS16390
uniprot id: Q67J78
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CutC family.
messages: Cytoplasm
messages: Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.

292459:STH RS00475
gene id: 292459:STH_RS00475
uniprot id: Q67TC2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

292459:STH RS05840
gene id: 292459:STH_RS05840
uniprot id: Q67QB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

292459:STH RS12255
gene id: 292459:STH_RS12255
uniprot id: Q67LJ7
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

292459:STH RS04910
gene id: 292459:STH_RS04910
uniprot id: Q67QV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Membrane

292459:STH RS10545
gene id: 292459:STH_RS10545
uniprot id: Q67MK6
names: Similarity
messages: Belongs to the peptidase S9C family.

292459:STH RS05430
gene id: 292459:STH_RS05430
uniprot id: Q67QJ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

292459:STH RS05940
gene id: 292459:STH_RS05940
uniprot id: Q67Q93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

292459:STH RS03815
gene id: 292459:STH_RS03815
uniprot id: Q67RG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

292459:STH RS03320
gene id: 292459:STH_RS03320
uniprot id: Q67RR3
names: Cofactor
messages: Binds 1 FAD per subunit.

292459:STH RS08145
gene id: 292459:STH_RS08145
uniprot id: Q67NZ3
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS11445
gene id: 292459:STH_RS11445
uniprot id: Q67M13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

292459:STH RS15135
gene id: 292459:STH_RS15135
uniprot id: Q67JX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).

292459:STH RS15570
gene id: 292459:STH_RS15570
uniprot id: Q67JN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

292459:STH RS01325
gene id: 292459:STH_RS01325
uniprot id: Q67SU9
names: Similarity
messages: Belongs to the asparagine synthetase family.

292459:STH RS07885
gene id: 292459:STH_RS07885
uniprot id: Q67P44
names: Similarity
messages: Belongs to the UbiD family.

292459:STH RS02595
gene id: 292459:STH_RS02595
uniprot id: Q67S58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

292459:STH RS11960
gene id: 292459:STH_RS11960
uniprot id: Q67LR2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS01220
gene id: 292459:STH_RS01220
uniprot id: Q67SX1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

292459:STH RS01305
gene id: 292459:STH_RS01305
uniprot id: Q67SV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS01590
gene id: 292459:STH_RS01590
uniprot id: Q67SQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS06075
gene id: 292459:STH_RS06075
uniprot id: Q67Q67
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

292459:STH RS13775
gene id: 292459:STH_RS13775
uniprot id: Q67KP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

292459:STH RS05640
gene id: 292459:STH_RS05640
uniprot id: Q67QF2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

292459:STH RS06280
gene id: 292459:STH_RS06280
uniprot id: Q67Q27
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

292459:STH RS01975
gene id: 292459:STH_RS01975
uniprot id: Q67SI2
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

292459:STH RS14560
gene id: 292459:STH_RS14560
uniprot id: Q67K88
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

292459:STH RS08680
gene id: 292459:STH_RS08680
uniprot id: Q67NN4
names: Subcellular Location Annotation
messages: Cell membrane

292459:STH RS05475
gene id: 292459:STH_RS05475
uniprot id: Q67QI5
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

292459:STH RS00355
gene id: 292459:STH_RS00355
uniprot id: Q67TE6
names: Similarity
messages: Belongs to the peptidase S8 family.

292459:STH RS06160
gene id: 292459:STH_RS06160
uniprot id: Q67Q51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

292459:STH RS09095
gene id: 292459:STH_RS09095
uniprot id: Q67NF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

292459:STH RS16020
gene id: 292459:STH_RS16020
uniprot id: Q67JE7
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS07770
gene id: 292459:STH_RS07770
uniprot id: Q67P67
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

292459:STH RS14535
gene id: 292459:STH_RS14535
uniprot id: Q67K93
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

292459:STH RS05145
gene id: 292459:STH_RS05145
uniprot id: Q67QQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

292459:STH RS10035
gene id: 292459:STH_RS10035
uniprot id: Q67MW0
names: Similarity
messages: Belongs to the UPF0297 family.

292459:STH RS17310
gene id: 292459:STH_RS17310
uniprot id: Q67ML4
names: Similarity
messages: Belongs to the SCO1/2 family.

292459:STH RS13110
gene id: 292459:STH_RS13110
uniprot id: Q67L25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

292459:STH RS00175
gene id: 292459:STH_RS00175
uniprot id: Q67TI9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

292459:STH RS08005
gene id: 292459:STH_RS08005
uniprot id: Q67P21
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

292459:STH RS04780
gene id: 292459:STH_RS04780
uniprot id: Q67QX6
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

292459:STH RS14960
gene id: 292459:STH_RS14960
uniprot id: Q67K08
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

292459:STH RS02390
gene id: 292459:STH_RS02390
uniprot id: Q67S99
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

292459:STH RS14530
gene id: 292459:STH_RS14530
uniprot id: Q67K94
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

292459:STH RS06055
gene id: 292459:STH_RS06055
uniprot id: Q67Q70
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

292459:STH RS16005
gene id: 292459:STH_RS16005
uniprot id: Q67JF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS14100
gene id: 292459:STH_RS14100
uniprot id: Q67KI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

292459:STH RS01775
gene id: 292459:STH_RS01775
uniprot id: Q67SL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

292459:STH RS07350
gene id: 292459:STH_RS07350
uniprot id: Q67PF3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

292459:STH RS10855
gene id: 292459:STH_RS10855
uniprot id: Q67ME4
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

292459:STH RS14980
gene id: 292459:STH_RS14980
uniprot id: Q67K04
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

292459:STH RS01230
gene id: 292459:STH_RS01230
uniprot id: Q67SW9
names: Similarity
messages: Belongs to the sigma-54 factor family.

292459:STH RS06265
gene id: 292459:STH_RS06265
uniprot id: Q67Q30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

292459:STH RS11370
gene id: 292459:STH_RS11370
uniprot id: Q67M29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

292459:STH RS16500
gene id: 292459:STH_RS16500
uniprot id: Q67R61
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS08230
gene id: 292459:STH_RS08230
uniprot id: Q67NX5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

292459:STH RS14615
gene id: 292459:STH_RS14615
uniprot id: Q67K77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

292459:STH RS13350
gene id: 292459:STH_RS13350
uniprot id: Q67KX5
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

292459:STH RS07580
gene id: 292459:STH_RS07580
uniprot id: Q67PA6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

292459:STH RS06270
gene id: 292459:STH_RS06270
uniprot id: Q67Q29
names: Similarity
messages: Belongs to the YggT family.

292459:STH RS14880
gene id: 292459:STH_RS14880
uniprot id: Q67K24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

292459:STH RS04370
gene id: 292459:STH_RS04370
uniprot id: Q67R63
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

292459:STH RS01585
gene id: 292459:STH_RS01585
uniprot id: Q67SR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS00575
gene id: 292459:STH_RS00575
uniprot id: Q67TA2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

292459:STH RS11980
gene id: 292459:STH_RS11980
uniprot id: Q67LQ8
names: Similarity
messages: Belongs to the threonine aldolase family.

292459:STH RS14510
gene id: 292459:STH_RS14510
uniprot id: Q67K98
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

292459:STH RS14890
gene id: 292459:STH_RS14890
uniprot id: Q67K22
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

292459:STH RS00975
gene id: 292459:STH_RS00975
uniprot id: Q67T21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

292459:STH RS06140
gene id: 292459:STH_RS06140
uniprot id: Q67Q54
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

292459:STH RS15190
gene id: 292459:STH_RS15190
uniprot id: Q67JW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

292459:STH RS15160
gene id: 292459:STH_RS15160
uniprot id: Q67JW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

292459:STH RS13010
gene id: 292459:STH_RS13010
uniprot id: Q67L47
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

292459:STH RS15835
gene id: 292459:STH_RS15835
uniprot id: Q67JI3
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

292459:STH RS03730
gene id: 292459:STH_RS03730
uniprot id: Q67RH9
names: Similarity
messages: Belongs to the cytochrome c-552 family.

292459:STH RS16455
gene id: 292459:STH_RS16455
uniprot id: Q67J65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

292459:STH RS12235
gene id: 292459:STH_RS12235
uniprot id: Q67LK2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

292459:STH RS06790
gene id: 292459:STH_RS06790
uniprot id: Q67PR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

292459:STH RS08710
gene id: 292459:STH_RS08710
uniprot id: Q67NM8
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS06780
gene id: 292459:STH_RS06780
uniprot id: Q67PS0
names: Similarity
messages: Belongs to the RemA family.

292459:STH RS10380
gene id: 292459:STH_RS10380
uniprot id: Q67MP0
names: Function
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

292459:STH RS06175
gene id: 292459:STH_RS06175
uniprot id: Q67Q48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

292459:STH RS07820
gene id: 292459:STH_RS07820
uniprot id: Q67P57
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS16550
gene id: 292459:STH_RS16550
uniprot id: Q67J48
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

292459:STH RS10115
gene id: 292459:STH_RS10115
uniprot id: Q67R61
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS07275
gene id: 292459:STH_RS07275
uniprot id: Q67PG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

292459:STH RS14495
gene id: 292459:STH_RS14495
uniprot id: Q67KA1
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS04245
gene id: 292459:STH_RS04245
uniprot id: Q67R86
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS07710
gene id: 292459:STH_RS07710
uniprot id: Q67P79
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

292459:STH RS09285
gene id: 292459:STH_RS09285
uniprot id: Q67NB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

292459:STH RS10470
gene id: 292459:STH_RS10470
uniprot id: Q67MM1
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS12215
gene id: 292459:STH_RS12215
uniprot id: Q67LK7
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

292459:STH RS03960
gene id: 292459:STH_RS03960
uniprot id: Q67RE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

292459:STH RS00625
gene id: 292459:STH_RS00625
uniprot id: Q67T91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

292459:STH RS18640
gene id: 292459:STH_RS18640
uniprot id: Q67S98
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS09190
gene id: 292459:STH_RS09190
uniprot id: Q67ND2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family.
messages: Cytoplasm

292459:STH RS00565
gene id: 292459:STH_RS00565
uniprot id: Q67TA4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

292459:STH RS04155
gene id: 292459:STH_RS04155
uniprot id: Q67RA7
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS16160
gene id: 292459:STH_RS16160
uniprot id: Q67JB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

292459:STH RS01960
gene id: 292459:STH_RS01960
uniprot id: Q67SI5
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

292459:STH RS06640
gene id: 292459:STH_RS06640
uniprot id: Q67PV0
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

292459:STH RS01945
gene id: 292459:STH_RS01945
uniprot id: Q67SI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

292459:STH RS06880
gene id: 292459:STH_RS06880
uniprot id: Q67PP9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

292459:STH RS06285
gene id: 292459:STH_RS06285
uniprot id: Q67Q26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TatA/E family.
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

292459:STH RS14450
gene id: 292459:STH_RS14450
uniprot id: Q67KB0
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
messages: May be involved in the biosynthesis of molybdopterin.

292459:STH RS10145
gene id: 292459:STH_RS10145
uniprot id: Q67MT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CotF family.
messages: Spore coat

292459:STH RS03010
gene id: 292459:STH_RS03010
uniprot id: Q67RX5
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

292459:STH RS15290
gene id: 292459:STH_RS15290
uniprot id: Q67JU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

292459:STH RS00440
gene id: 292459:STH_RS00440
uniprot id: Q67TC9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

292459:STH RS15345
gene id: 292459:STH_RS15345
uniprot id: Q67JS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

292459:STH RS16310
gene id: 292459:STH_RS16310
uniprot id: Q67J94
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

292459:STH RS14230
gene id: 292459:STH_RS14230
uniprot id: Q67KF3
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

292459:STH RS12565
gene id: 292459:STH_RS12565
uniprot id: Q67LD5
names: Function
names: Similarity
messages: Belongs to the PduL family.
messages: Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.

292459:STH RS07135
gene id: 292459:STH_RS07135
uniprot id: Q67PJ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

292459:STH RS02655
gene id: 292459:STH_RS02655
uniprot id: Q67S46
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

292459:STH RS12865
gene id: 292459:STH_RS12865
uniprot id: Q67L76
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

292459:STH RS05005
gene id: 292459:STH_RS05005
uniprot id: Q67QT1
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS06335
gene id: 292459:STH_RS06335
uniprot id: Q67Q16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

292459:STH RS08120
gene id: 292459:STH_RS08120
uniprot id: Q67NZ8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.

292459:STH RS04385
gene id: 292459:STH_RS04385
uniprot id: Q67R60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

292459:STH RS16075
gene id: 292459:STH_RS16075
uniprot id: Q67JD6
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS14490
gene id: 292459:STH_RS14490
uniprot id: Q67KA2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

292459:STH RS15665
gene id: 292459:STH_RS15665
uniprot id: Q67JL5
names: Cofactor
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.

292459:STH RS08300
gene id: 292459:STH_RS08300
uniprot id: Q67NW1
names: Similarity
messages: Belongs to the DEAD box helicase family.

292459:STH RS09945
gene id: 292459:STH_RS09945
uniprot id: Q67MX5
names: Cofactor
messages: Binds 1 zinc ion per subunit.

292459:STH RS07595
gene id: 292459:STH_RS07595
uniprot id: Q67PA2
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

292459:STH RS02380
gene id: 292459:STH_RS02380
uniprot id: Q67SA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

292459:STH RS09925
gene id: 292459:STH_RS09925
uniprot id: Q67MX9
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.

292459:STH RS00505
gene id: 292459:STH_RS00505
uniprot id: Q67TB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

292459:STH RS02500
gene id: 292459:STH_RS02500
uniprot id: Q67S78
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

292459:STH RS14605
gene id: 292459:STH_RS14605
uniprot id: Q67K79
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

292459:STH RS13075
gene id: 292459:STH_RS13075
uniprot id: Q67L32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS05040
gene id: 292459:STH_RS05040
uniprot id: Q67QS4
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS15225
gene id: 292459:STH_RS15225
uniprot id: Q67JV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

292459:STH RS07395
gene id: 292459:STH_RS07395
uniprot id: Q67PE3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

292459:STH RS16235
gene id: 292459:STH_RS16235
uniprot id: Q67JB0
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

292459:STH RS08340
gene id: 292459:STH_RS08340
uniprot id: Q67NV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit B family.
messages: Cell membrane
messages: Membrane

292459:STH RS07340
gene id: 292459:STH_RS07340
uniprot id: Q67PF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

292459:STH RS04600
gene id: 292459:STH_RS04600
uniprot id: Q67R14
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS00430
gene id: 292459:STH_RS00430
uniprot id: Q67TD1
names: Similarity
messages: Belongs to the LacAB/RpiB family.

292459:STH RS15265
gene id: 292459:STH_RS15265
uniprot id: Q67JU7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

292459:STH RS14675
gene id: 292459:STH_RS14675
uniprot id: Q67K65
names: Similarity
messages: Belongs to the UPF0312 family.

292459:STH RS00490
gene id: 292459:STH_RS00490
uniprot id: Q67TB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

292459:STH RS14240
gene id: 292459:STH_RS14240
uniprot id: Q67KF1
names: Similarity
messages: Belongs to the ThiD family.

292459:STH RS12185
gene id: 292459:STH_RS12185
uniprot id: Q67LL3
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS03240
gene id: 292459:STH_RS03240
uniprot id: Q67RS8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

292459:STH RS07420
gene id: 292459:STH_RS07420
uniprot id: Q67PD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

292459:STH RS15125
gene id: 292459:STH_RS15125
uniprot id: Q67JX5
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS00270
gene id: 292459:STH_RS00270
uniprot id: Q67TG8
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

292459:STH RS06165
gene id: 292459:STH_RS06165
uniprot id: Q67Q50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane

292459:STH RS15140
gene id: 292459:STH_RS15140
uniprot id: Q67JX2
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

292459:STH RS07445
gene id: 292459:STH_RS07445
uniprot id: Q67PD3
names: Similarity
messages: Belongs to the UPF0102 family.

292459:STH RS15310
gene id: 292459:STH_RS15310
uniprot id: Q67JT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

292459:STH RS00525
gene id: 292459:STH_RS00525
uniprot id: Q67TB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

292459:STH RS13745
gene id: 292459:STH_RS13745
uniprot id: Q67KQ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class U subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

292459:STH RS01675
gene id: 292459:STH_RS01675
uniprot id: Q67SN7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

292459:STH RS00620
gene id: 292459:STH_RS00620
uniprot id: Q67T93
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

292459:STH RS02170
gene id: 292459:STH_RS02170
uniprot id: Q67SE3
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS14015
gene id: 292459:STH_RS14015
uniprot id: Q67KJ5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

292459:STH RS12720
gene id: 292459:STH_RS12720
uniprot id: Q67LA4
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

292459:STH RS02955
gene id: 292459:STH_RS02955
uniprot id: Q67RY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS08295
gene id: 292459:STH_RS08295
uniprot id: Q67NW2
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

292459:STH RS04535
gene id: 292459:STH_RS04535
uniprot id: Q67R27
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

292459:STH RS07695
gene id: 292459:STH_RS07695
uniprot id: Q67P82
names: Similarity
messages: Belongs to the ribF family.

292459:STH RS01010
gene id: 292459:STH_RS01010
uniprot id: Q67T14
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

292459:STH RS00410
gene id: 292459:STH_RS00410
uniprot id: Q67TD5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

292459:STH RS14925
gene id: 292459:STH_RS14925
uniprot id: Q67K15
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

292459:STH RS06095
gene id: 292459:STH_RS06095
uniprot id: Q67Q63
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the FGGY kinase family.
messages: Homotetramer and homodimer (in equilibrium).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

292459:STH RS08925
gene id: 292459:STH_RS08925
uniprot id: Q67NI4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

292459:STH RS07200
gene id: 292459:STH_RS07200
uniprot id: Q67PI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS04545
gene id: 292459:STH_RS04545
uniprot id: Q67R25
names: Similarity
messages: Belongs to the CapA family.

292459:STH RS00860
gene id: 292459:STH_RS00860
uniprot id: Q67T44
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

292459:STH RS09685
gene id: 292459:STH_RS09685
uniprot id: Q67N30
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

292459:STH RS06275
gene id: 292459:STH_RS06275
uniprot id: Q67Q28
names: Subcellular Location Annotation
messages: Cytoplasm

292459:STH RS10500
gene id: 292459:STH_RS10500
uniprot id: Q67ML5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Interacts with CtaA.

292459:STH RS03760
gene id: 292459:STH_RS03760
uniprot id: Q67RH3
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS14180
gene id: 292459:STH_RS14180
uniprot id: Q67KG4
names: Similarity
messages: Belongs to the GARS family.

292459:STH RS09255
gene id: 292459:STH_RS09255
uniprot id: Q67NB7
names: Similarity
messages: Belongs to the TlyA family.

292459:STH RS15725
gene id: 292459:STH_RS15725
uniprot id: Q67JK4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

292459:STH RS12960
gene id: 292459:STH_RS12960
uniprot id: Q67L57
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

292459:STH RS02450
gene id: 292459:STH_RS02450
uniprot id: Q67S87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

292459:STH RS13300
gene id: 292459:STH_RS13300
uniprot id: Q67KY5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

292459:STH RS16065
gene id: 292459:STH_RS16065
uniprot id: Q67JD8
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

292459:STH RS06205
gene id: 292459:STH_RS06205
uniprot id: Q67Q42
names: Similarity
messages: Belongs to the UPF0749 family.

292459:STH RS02760
gene id: 292459:STH_RS02760
uniprot id: Q67S25
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

292459:STH RS00180
gene id: 292459:STH_RS00180
uniprot id: Q67R61
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS13225
gene id: 292459:STH_RS13225
uniprot id: Q67L01
names: Similarity
messages: Belongs to the arginase family.

292459:STH RS14385
gene id: 292459:STH_RS14385
uniprot id: Q67KC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

292459:STH RS02510
gene id: 292459:STH_RS02510
uniprot id: Q67S76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

292459:STH RS11120
gene id: 292459:STH_RS11120
uniprot id: Q67M86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

292459:STH RS16105
gene id: 292459:STH_RS16105
uniprot id: Q67JD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

292459:STH RS00415
gene id: 292459:STH_RS00415
uniprot id: Q67TD4
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

292459:STH RS17155
gene id: 292459:STH_RS17155
uniprot id: Q67NZ9
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS07565
gene id: 292459:STH_RS07565
uniprot id: Q67PA9
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

292459:STH RS12645
gene id: 292459:STH_RS12645
uniprot id: Q67LB9
names: Similarity
messages: Belongs to the citrate synthase family.

292459:STH RS03035
gene id: 292459:STH_RS03035
uniprot id: Q67RX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

292459:STH RS00840
gene id: 292459:STH_RS00840
uniprot id: Q67T48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.

292459:STH RS05835
gene id: 292459:STH_RS05835
uniprot id: Q67QB5
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

292459:STH RS04320
gene id: 292459:STH_RS04320
uniprot id: Q67R72
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

292459:STH RS01020
gene id: 292459:STH_RS01020
uniprot id: Q67T12
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

292459:STH RS02970
gene id: 292459:STH_RS02970
uniprot id: Q67RY3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

292459:STH RS10440
gene id: 292459:STH_RS10440
uniprot id: Q67MM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

292459:STH RS04990
gene id: 292459:STH_RS04990
uniprot id: Q67QT4
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS06250
gene id: 292459:STH_RS06250
uniprot id: Q67Q33
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

292459:STH RS08385
gene id: 292459:STH_RS08385
uniprot id: Q67NU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

292459:STH RS09220
gene id: 292459:STH_RS09220
uniprot id: Q67NC6
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cytoplasm
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS03045
gene id: 292459:STH_RS03045
uniprot id: Q67RW8
names: Cofactor
messages: Can also use Mn(2+) ion.

292459:STH RS06410
gene id: 292459:STH_RS06410
uniprot id: Q67Q01
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

292459:STH RS09960
gene id: 292459:STH_RS09960
uniprot id: Q67MX2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.
messages: Membrane

292459:STH RS07180
gene id: 292459:STH_RS07180
uniprot id: Q67PI9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

292459:STH RS03170
gene id: 292459:STH_RS03170
uniprot id: Q67RU2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

292459:STH RS12135
gene id: 292459:STH_RS12135
uniprot id: Q67LM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

292459:STH RS00735
gene id: 292459:STH_RS00735
uniprot id: Q67T69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

292459:STH RS04390
gene id: 292459:STH_RS04390
uniprot id: Q67R59
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

292459:STH RS12610
gene id: 292459:STH_RS12610
uniprot id: Q67LC6
names: Similarity
messages: Belongs to the class-I fumarase family.

292459:STH RS02800
gene id: 292459:STH_RS02800
uniprot id: Q67S17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

292459:STH RS15850
gene id: 292459:STH_RS15850
uniprot id: Q67JI0
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

292459:STH RS15180
gene id: 292459:STH_RS15180
uniprot id: Q67JW4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

292459:STH RS05270
gene id: 292459:STH_RS05270
uniprot id: Q67QM8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

292459:STH RS10190
gene id: 292459:STH_RS10190
uniprot id: Q67MS9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

292459:STH RS02205
gene id: 292459:STH_RS02205
uniprot id: Q67SD7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

292459:STH RS06150
gene id: 292459:STH_RS06150
uniprot id: Q67Q53
names: Similarity
messages: Belongs to the transpeptidase family.

292459:STH RS02770
gene id: 292459:STH_RS02770
uniprot id: Q67S23
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

292459:STH RS11995
gene id: 292459:STH_RS11995
uniprot id: Q67LQ4
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS04690
gene id: 292459:STH_RS04690
uniprot id: Q67QZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

292459:STH RS08310
gene id: 292459:STH_RS08310
uniprot id: Q67NV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

292459:STH RS15385
gene id: 292459:STH_RS15385
uniprot id: Q67JS2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS17735
gene id: 292459:STH_RS17735
uniprot id: Q67JC7
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

292459:STH RS03945
gene id: 292459:STH_RS03945
uniprot id: Q67RF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS07330
gene id: 292459:STH_RS07330
uniprot id: Q67PF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

292459:STH RS09380
gene id: 292459:STH_RS09380
uniprot id: Q67N92
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

292459:STH RS14780
gene id: 292459:STH_RS14780
uniprot id: Q67K42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

292459:STH RS00030
gene id: 292459:STH_RS00030
uniprot id: Q67TK2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

292459:STH RS16630
gene id: 292459:STH_RS16630
uniprot id: Q67J30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

292459:STH RS02140
gene id: 292459:STH_RS02140
uniprot id: Q67SE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

292459:STH RS15590
gene id: 292459:STH_RS15590
uniprot id: Q67JN2
names: Similarity
messages: Belongs to the CtsR family.

292459:STH RS02245
gene id: 292459:STH_RS02245
uniprot id: Q67SC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

292459:STH RS07705
gene id: 292459:STH_RS07705
uniprot id: Q67P80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

292459:STH RS05635
gene id: 292459:STH_RS05635
uniprot id: Q67QF3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

292459:STH RS15300
gene id: 292459:STH_RS15300
uniprot id: Q67JU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

292459:STH RS05580
gene id: 292459:STH_RS05580
uniprot id: Q67QG5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

292459:STH RS10005
gene id: 292459:STH_RS10005
uniprot id: Q67MW6
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

292459:STH RS08485
gene id: 292459:STH_RS08485
uniprot id: Q67NS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

292459:STH RS14025
gene id: 292459:STH_RS14025
uniprot id: Q67KJ3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

292459:STH RS05260
gene id: 292459:STH_RS05260
uniprot id: Q67QN0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

292459:STH RS05280
gene id: 292459:STH_RS05280
uniprot id: Q67QM6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

292459:STH RS15350
gene id: 292459:STH_RS15350
uniprot id: Q67JS8
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

292459:STH RS07655
gene id: 292459:STH_RS07655
uniprot id: Q67P90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

292459:STH RS05515
gene id: 292459:STH_RS05515
uniprot id: Q67QH8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

292459:STH RS14115
gene id: 292459:STH_RS14115
uniprot id: Q67KH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

292459:STH RS10520
gene id: 292459:STH_RS10520
uniprot id: Q67ML1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

292459:STH RS14090
gene id: 292459:STH_RS14090
uniprot id: Q67KI2
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

292459:STH RS05910
gene id: 292459:STH_RS05910
uniprot id: Q67Q99
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

292459:STH RS09165
gene id: 292459:STH_RS09165
uniprot id: Q67ND7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

292459:STH RS13535
gene id: 292459:STH_RS13535
uniprot id: Q67KS8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

292459:STH RS14895
gene id: 292459:STH_RS14895
uniprot id: Q67K21
names: Similarity
messages: Belongs to the FlgD family.

292459:STH RS10100
gene id: 292459:STH_RS10100
uniprot id: Q67MU7
names: Similarity
messages: Belongs to the DtxR/MntR family.

292459:STH RS17570
gene id: 292459:STH_RS17570
uniprot id: Q67JZ2
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS06360
gene id: 292459:STH_RS06360
uniprot id: Q67Q11
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS03475
gene id: 292459:STH_RS03475
uniprot id: Q67RN0
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS00075
gene id: 292459:STH_RS00075
uniprot id: Q67TJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

292459:STH RS09170
gene id: 292459:STH_RS09170
uniprot id: Q67ND6
names: Similarity
messages: Belongs to the AlaDH/PNT family.

292459:STH RS14940
gene id: 292459:STH_RS14940
uniprot id: Q67K12
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

292459:STH RS02755
gene id: 292459:STH_RS02755
uniprot id: Q67S26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane

292459:STH RS12030
gene id: 292459:STH_RS12030
uniprot id: Q67LP5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.

292459:STH RS03715
gene id: 292459:STH_RS03715
uniprot id: Q67RI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

292459:STH RS07570
gene id: 292459:STH_RS07570
uniprot id: Q67PA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

292459:STH RS12210
gene id: 292459:STH_RS12210
uniprot id: Q67LK8
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

292459:STH RS04795
gene id: 292459:STH_RS04795
uniprot id: Q67QX3
names: Similarity
messages: Belongs to the class-D beta-lactamase family.

292459:STH RS00610
gene id: 292459:STH_RS00610
uniprot id: Q67T95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

292459:STH RS13710
gene id: 292459:STH_RS13710
uniprot id: Q67KQ8
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

292459:STH RS08460
gene id: 292459:STH_RS08460
uniprot id: Q67NS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

292459:STH RS17185
gene id: 292459:STH_RS17185
uniprot id: Q67NP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

292459:STH RS16385
gene id: 292459:STH_RS16385
uniprot id: Q67J79
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS11650
gene id: 292459:STH_RS11650
uniprot id: Q67LX4
names: Similarity
messages: Belongs to the LacAB/RpiB family.

292459:STH RS00995
gene id: 292459:STH_RS00995
uniprot id: Q67T17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

292459:STH RS00185
gene id: 292459:STH_RS00185
uniprot id: Q67TI7
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS04885
gene id: 292459:STH_RS04885
uniprot id: Q67QV5
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

292459:STH RS12895
gene id: 292459:STH_RS12895
uniprot id: Q67L70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

292459:STH RS13365
gene id: 292459:STH_RS13365
uniprot id: Q67KX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

292459:STH RS06450
gene id: 292459:STH_RS06450
uniprot id: Q67PZ3
names: Similarity
messages: Belongs to the UPF0145 family.

292459:STH RS10590
gene id: 292459:STH_RS10590
uniprot id: Q67MJ7
names: Similarity
messages: Belongs to the EamA transporter family.

292459:STH RS04580
gene id: 292459:STH_RS04580
uniprot id: Q67R18
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

292459:STH RS04940
gene id: 292459:STH_RS04940
uniprot id: Q67QU4
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

292459:STH RS12600
gene id: 292459:STH_RS12600
uniprot id: Q67LC8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

292459:STH RS07110
gene id: 292459:STH_RS07110
uniprot id: Q67PK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

292459:STH RS15715
gene id: 292459:STH_RS15715
uniprot id: Q67JK6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS00740
gene id: 292459:STH_RS00740
uniprot id: Q67T68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.

292459:STH RS04530
gene id: 292459:STH_RS04530
uniprot id: Q67R28
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS08025
gene id: 292459:STH_RS08025
uniprot id: Q67P17
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

292459:STH RS14105
gene id: 292459:STH_RS14105
uniprot id: Q67KH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

292459:STH RS00400
gene id: 292459:STH_RS00400
uniprot id: Q67TD7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

292459:STH RS16350
gene id: 292459:STH_RS16350
uniprot id: Q67J86
names: Similarity
messages: Belongs to the AOR/FOR family.

292459:STH RS03310
gene id: 292459:STH_RS03310
uniprot id: Q67RR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

292459:STH RS06885
gene id: 292459:STH_RS06885
uniprot id: Q67PP8
names: Similarity
messages: Belongs to the asp23 family.

292459:STH RS05590
gene id: 292459:STH_RS05590
uniprot id: Q67QG3
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS06675
gene id: 292459:STH_RS06675
uniprot id: Q67PU3
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

292459:STH RS15260
gene id: 292459:STH_RS15260
uniprot id: Q67JU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

292459:STH RS01770
gene id: 292459:STH_RS01770
uniprot id: Q67SL6
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

292459:STH RS00050
gene id: 292459:STH_RS00050
uniprot id: Q67TJ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

292459:STH RS09500
gene id: 292459:STH_RS09500
uniprot id: Q67N67
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.

292459:STH RS06220
gene id: 292459:STH_RS06220
uniprot id: Q67Q39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

292459:STH RS14555
gene id: 292459:STH_RS14555
uniprot id: Q67K89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

292459:STH RS12515
gene id: 292459:STH_RS12515
uniprot id: Q67LE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS00220
gene id: 292459:STH_RS00220
uniprot id: Q67TH9
names: Similarity
messages: Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family.

292459:STH RS15000
gene id: 292459:STH_RS15000
uniprot id: Q67JZ9
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS03685
gene id: 292459:STH_RS03685
uniprot id: Q67RI8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

292459:STH RS15240
gene id: 292459:STH_RS15240
uniprot id: Q67JV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

292459:STH RS12725
gene id: 292459:STH_RS12725
uniprot id: Q67LA3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

292459:STH RS00685
gene id: 292459:STH_RS00685
uniprot id: Q67T79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS11620
gene id: 292459:STH_RS11620
uniprot id: Q67LY0
names: Function
messages: Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.

292459:STH RS02605
gene id: 292459:STH_RS02605
uniprot id: Q67S56
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

292459:STH RS04420
gene id: 292459:STH_RS04420
uniprot id: Q67R53
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS05465
gene id: 292459:STH_RS05465
uniprot id: Q67QI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

292459:STH RS12385
gene id: 292459:STH_RS12385
uniprot id: Q67LH1
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

292459:STH RS12510
gene id: 292459:STH_RS12510
uniprot id: Q67LE6
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

292459:STH RS13080
gene id: 292459:STH_RS13080
uniprot id: Q67L31
names: Similarity
messages: Belongs to the ABC transporter superfamily.

292459:STH RS14455
gene id: 292459:STH_RS14455
uniprot id: Q67KA9
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
messages: May be involved in the biosynthesis of molybdopterin.

292459:STH RS08540
gene id: 292459:STH_RS08540
uniprot id: Q67NR2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase involved in purine salvage.

292459:STH RS15155
gene id: 292459:STH_RS15155
uniprot id: Q67JW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

292459:STH RS13860
gene id: 292459:STH_RS13860
uniprot id: Q67KM6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

292459:STH RS02080
gene id: 292459:STH_RS02080
uniprot id: Q67SG1
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS09800
gene id: 292459:STH_RS09800
uniprot id: Q67N07
names: Similarity
messages: Belongs to the peptidase A24 family.

292459:STH RS03820
gene id: 292459:STH_RS03820
uniprot id: Q67RG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

292459:STH RS14295
gene id: 292459:STH_RS14295
uniprot id: Q67KE1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

292459:STH RS00655
gene id: 292459:STH_RS00655
uniprot id: Q67T85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

292459:STH RS15145
gene id: 292459:STH_RS15145
uniprot id: Q67JX1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

292459:STH RS09160
gene id: 292459:STH_RS09160
uniprot id: Q67ND8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

292459:STH RS00580
gene id: 292459:STH_RS00580
uniprot id: Q67TA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

292459:STH RS14125
gene id: 292459:STH_RS14125
uniprot id: Q67KH5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

292459:STH RS16780
gene id: 292459:STH_RS16780
uniprot id: Q67S32
names: Similarity
messages: Belongs to the CapA family.

292459:STH RS06795
gene id: 292459:STH_RS06795
uniprot id: Q67PR7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

292459:STH RS02635
gene id: 292459:STH_RS02635
uniprot id: Q67S50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

292459:STH RS00455
gene id: 292459:STH_RS00455
uniprot id: Q67TC6
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

292459:STH RS09675
gene id: 292459:STH_RS09675
uniprot id: Q67N32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

292459:STH RS06350
gene id: 292459:STH_RS06350
uniprot id: Q67Q13
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

292459:STH RS05315
gene id: 292459:STH_RS05315
uniprot id: Q67QL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
messages: Homodimer.

292459:STH RS07415
gene id: 292459:STH_RS07415
uniprot id: Q67PD9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

292459:STH RS16520
gene id: 292459:STH_RS16520
uniprot id: Q67J54
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

292459:STH RS03835
gene id: 292459:STH_RS03835
uniprot id: Q67RF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

292459:STH RS12055
gene id: 292459:STH_RS12055
uniprot id: Q67LN9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

292459:STH RS15515
gene id: 292459:STH_RS15515
uniprot id: Q67JP6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

292459:STH RS15705
gene id: 292459:STH_RS15705
uniprot id: Q67JK8
names: Similarity
messages: Belongs to the UPF0173 family.

292459:STH RS02255
gene id: 292459:STH_RS02255
uniprot id: Q67SC7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

292459:STH RS15355
gene id: 292459:STH_RS15355
uniprot id: Q67JS7
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

292459:STH RS10220
gene id: 292459:STH_RS10220
uniprot id: Q67MS3
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

292459:STH RS09025
gene id: 292459:STH_RS09025
uniprot id: Q67NG4
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS00765
gene id: 292459:STH_RS00765
uniprot id: Q67T63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS15185
gene id: 292459:STH_RS15185
uniprot id: Q67JW3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

292459:STH RS01255
gene id: 292459:STH_RS01255
uniprot id: Q67SW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

292459:STH RS03225
gene id: 292459:STH_RS03225
uniprot id: Q67RT1
names: Similarity
messages: Belongs to the ArsC family.

292459:STH RS03115
gene id: 292459:STH_RS03115
uniprot id: Q67RV3
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

292459:STH RS08480
gene id: 292459:STH_RS08480
uniprot id: Q67NS4
names: Function
names: Subcellular Location Annotation
messages: ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
messages: Cytoplasm

292459:STH RS01955
gene id: 292459:STH_RS01955
uniprot id: Q67SI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

292459:STH RS10155
gene id: 292459:STH_RS10155
uniprot id: Q67MT6
names: Similarity
messages: Belongs to the UPF0236 family.

292459:STH RS13135
gene id: 292459:STH_RS13135
uniprot id: Q67L20
names: Similarity
messages: Belongs to the class-I fumarase family.

292459:STH RS00380
gene id: 292459:STH_RS00380
uniprot id: Q67TE1
names: Similarity
messages: Belongs to the FBPase class 2 family.

292459:STH RS11755
gene id: 292459:STH_RS11755
uniprot id: Q67LV4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

292459:STH RS09630
gene id: 292459:STH_RS09630
uniprot id: Q67N41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

292459:STH RS04860
gene id: 292459:STH_RS04860
uniprot id: Q67QW0
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

292459:STH RS09195
gene id: 292459:STH_RS09195
uniprot id: Q67ND1
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

292459:STH RS08045
gene id: 292459:STH_RS08045
uniprot id: Q67P13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

292459:STH RS01780
gene id: 292459:STH_RS01780
uniprot id: Q67SL4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

292459:STH RS11780
gene id: 292459:STH_RS11780
uniprot id: Q67LU9
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

292459:STH RS09780
gene id: 292459:STH_RS09780
uniprot id: Q67N11
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine-5'-phosphate glycosidase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
messages: Homotrimer.

292459:STH RS13125
gene id: 292459:STH_RS13125
uniprot id: Q67L22
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

292459:STH RS12435
gene id: 292459:STH_RS12435
uniprot id: Q67LG1
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.

292459:STH RS16450
gene id: 292459:STH_RS16450
uniprot id: Q67J66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

292459:STH RS14035
gene id: 292459:STH_RS14035
uniprot id: Q67KJ1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

292459:STH RS06425
gene id: 292459:STH_RS06425
uniprot id: Q67PZ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

292459:STH RS00040
gene id: 292459:STH_RS00040
uniprot id: Q67TK0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

292459:STH RS08545
gene id: 292459:STH_RS08545
uniprot id: Q67NR1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

292459:STH RS12155
gene id: 292459:STH_RS12155
uniprot id: Q67LL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

292459:STH RS14375
gene id: 292459:STH_RS14375
uniprot id: Q67KC5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

292459:STH RS05470
gene id: 292459:STH_RS05470
uniprot id: Q67QI6
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

292459:STH RS06555
gene id: 292459:STH_RS06555
uniprot id: Q67PX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

292459:STH RS02270
gene id: 292459:STH_RS02270
uniprot id: Q67SC4
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

292459:STH RS04915
gene id: 292459:STH_RS04915
uniprot id: Q67QU9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

292459:STH RS01300
gene id: 292459:STH_RS01300
uniprot id: Q67SV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
messages: Cell membrane
messages: Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ).

292459:STH RS14445
gene id: 292459:STH_RS14445
uniprot id: Q67KB1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

292459:STH RS04160
gene id: 292459:STH_RS04160
uniprot id: Q67RA6
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS07845
gene id: 292459:STH_RS07845
uniprot id: Q67P52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

292459:STH RS14785
gene id: 292459:STH_RS14785
uniprot id: Q67K41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

292459:STH RS03030
gene id: 292459:STH_RS03030
uniprot id: Q67RX1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

292459:STH RS08500
gene id: 292459:STH_RS08500
uniprot id: Q67NS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuC/DcuD transporter (TC 2.A.61) family.
messages: Membrane

292459:STH RS03645
gene id: 292459:STH_RS03645
uniprot id: Q67RJ6
names: Function
messages: Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.

292459:STH RS13170
gene id: 292459:STH_RS13170
uniprot id: Q67L13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0756 family.
messages: Cell membrane

292459:STH RS16240
gene id: 292459:STH_RS16240
uniprot id: Q67JA9
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

292459:STH RS07390
gene id: 292459:STH_RS07390
uniprot id: Q67PE4
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

292459:STH RS02600
gene id: 292459:STH_RS02600
uniprot id: Q67S57
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

292459:STH RS01240
gene id: 292459:STH_RS01240
uniprot id: Q67SW7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

292459:STH RS07785
gene id: 292459:STH_RS07785
uniprot id: Q67P64
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

292459:STH RS00780
gene id: 292459:STH_RS00780
uniprot id: Q67T60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS04380
gene id: 292459:STH_RS04380
uniprot id: Q67R61
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS07140
gene id: 292459:STH_RS07140
uniprot id: Q67PJ8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

292459:STH RS13525
gene id: 292459:STH_RS13525
uniprot id: Q67KT0
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS06750
gene id: 292459:STH_RS06750
uniprot id: Q67PS6
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

292459:STH RS03765
gene id: 292459:STH_RS03765
uniprot id: Q67RH2
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS07610
gene id: 292459:STH_RS07610
uniprot id: Q67P99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

292459:STH RS06385
gene id: 292459:STH_RS06385
uniprot id: Q67Q06
names: Similarity
messages: Belongs to the SIS family. AgaS subfamily.

292459:STH RS01275
gene id: 292459:STH_RS01275
uniprot id: Q67SW0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

292459:STH RS14215
gene id: 292459:STH_RS14215
uniprot id: Q67KF7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

292459:STH RS14410
gene id: 292459:STH_RS14410
uniprot id: Q67KB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

292459:STH RS15270
gene id: 292459:STH_RS15270
uniprot id: Q67JU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

292459:STH RS08790
gene id: 292459:STH_RS08790
uniprot id: Q67NL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

292459:STH RS03500
gene id: 292459:STH_RS03500
uniprot id: Q67RM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

292459:STH RS06820
gene id: 292459:STH_RS06820
uniprot id: Q67R61
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS12965
gene id: 292459:STH_RS12965
uniprot id: Q67L56
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

292459:STH RS04630
gene id: 292459:STH_RS04630
uniprot id: Q67R08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

292459:STH RS01965
gene id: 292459:STH_RS01965
uniprot id: Q67SI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

292459:STH RS03970
gene id: 292459:STH_RS03970
uniprot id: Q67RE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

292459:STH RS13690
gene id: 292459:STH_RS13690
uniprot id: Q67KR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

292459:STH RS11405
gene id: 292459:STH_RS11405
uniprot id: Q67M21
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

292459:STH RS00390
gene id: 292459:STH_RS00390
uniprot id: Q67TD9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

292459:STH RS14420
gene id: 292459:STH_RS14420
uniprot id: Q67KB6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

292459:STH RS10835
gene id: 292459:STH_RS10835
uniprot id: Q67ME8
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

292459:STH RS10045
gene id: 292459:STH_RS10045
uniprot id: Q67MV8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

292459:STH RS16475
gene id: 292459:STH_RS16475
uniprot id: Q67J61
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS13875
gene id: 292459:STH_RS13875
uniprot id: Q67KM3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

292459:STH RS15970
gene id: 292459:STH_RS15970
uniprot id: Q67JF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family.
messages: Cell membrane
messages: Membrane

292459:STH RS16980
gene id: 292459:STH_RS16980
uniprot id: Q67QI4
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS00630
gene id: 292459:STH_RS00630
uniprot id: Q67T90
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

292459:STH RS01980
gene id: 292459:STH_RS01980
uniprot id: Q67SI1
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

292459:STH RS08795
gene id: 292459:STH_RS08795
uniprot id: Q67NL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Monomer.

292459:STH RS06785
gene id: 292459:STH_RS06785
uniprot id: Q67PR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

292459:STH RS09410
gene id: 292459:STH_RS09410
uniprot id: Q67N86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

292459:STH RS16615
gene id: 292459:STH_RS16615
uniprot id: Q67J33
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

292459:STH RS08785
gene id: 292459:STH_RS08785
uniprot id: Q67NL3
names: Similarity
messages: Belongs to the CbxX/CfxQ family.

292459:STH RS05720
gene id: 292459:STH_RS05720
uniprot id: Q67QE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

292459:STH RS15985
gene id: 292459:STH_RS15985
uniprot id: Q67JF4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS02315
gene id: 292459:STH_RS02315
uniprot id: Q67SB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

292459:STH RS12635
gene id: 292459:STH_RS12635
uniprot id: Q67LC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

292459:STH RS02515
gene id: 292459:STH_RS02515
uniprot id: Q67S75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

292459:STH RS12140
gene id: 292459:STH_RS12140
uniprot id: Q67LM2
names: Similarity
messages: Belongs to the RecJ family.

292459:STH RS05140
gene id: 292459:STH_RS05140
uniprot id: Q67QQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

292459:STH RS09205
gene id: 292459:STH_RS09205
uniprot id: Q67NC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family.
messages: Cytoplasm

292459:STH RS15640
gene id: 292459:STH_RS15640
uniprot id: Q67JM1
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS00820
gene id: 292459:STH_RS00820
uniprot id: Q67T52
names: Similarity
messages: Belongs to the ThiD family.

292459:STH RS01925
gene id: 292459:STH_RS01925
uniprot id: Q67SJ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

292459:STH RS14005
gene id: 292459:STH_RS14005
uniprot id: Q67KJ7
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

292459:STH RS12715
gene id: 292459:STH_RS12715
uniprot id: Q67LA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

292459:STH RS15295
gene id: 292459:STH_RS15295
uniprot id: Q67JU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

292459:STH RS08820
gene id: 292459:STH_RS08820
uniprot id: Q67NK6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

292459:STH RS14235
gene id: 292459:STH_RS14235
uniprot id: Q67KF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

292459:STH RS05625
gene id: 292459:STH_RS05625
uniprot id: Q67QF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

292459:STH RS06635
gene id: 292459:STH_RS06635
uniprot id: Q67PV1
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

292459:STH RS09110
gene id: 292459:STH_RS09110
uniprot id: Q67NE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

292459:STH RS09230
gene id: 292459:STH_RS09230
uniprot id: Q67NC3
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

292459:STH RS17150
gene id: 292459:STH_RS17150
uniprot id: Q67P01
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

292459:STH RS08080
gene id: 292459:STH_RS08080
uniprot id: Q67P06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

292459:STH RS04610
gene id: 292459:STH_RS04610
uniprot id: Q67R12
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

292459:STH RS08065
gene id: 292459:STH_RS08065
uniprot id: Q67N91
names: Similarity
messages: Belongs to the UPF0236 family.

292459:STH RS03740
gene id: 292459:STH_RS03740
uniprot id: Q67RH7
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS00010
gene id: 292459:STH_RS00010
uniprot id: Q67TK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

292459:STH RS00450
gene id: 292459:STH_RS00450
uniprot id: Q67TC7
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS11460
gene id: 292459:STH_RS11460
uniprot id: Q3V818
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxA family. PdxA2 subfamily.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP).
messages: Homodimer.

292459:STH RS15250
gene id: 292459:STH_RS15250
uniprot id: Q67JV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

292459:STH RS16015
gene id: 292459:STH_RS16015
uniprot id: Q67JE8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS07040
gene id: 292459:STH_RS07040
uniprot id: Q67PL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.

292459:STH RS04585
gene id: 292459:STH_RS04585
uniprot id: Q67R17
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

292459:STH RS07490
gene id: 292459:STH_RS07490
uniprot id: Q67PC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CodY family.
messages: Cytoplasm
messages: DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor.

292459:STH RS04710
gene id: 292459:STH_RS04710
uniprot id: Q67QZ0
names: Subcellular Location Annotation
messages: Cytoplasm

292459:STH RS11800
gene id: 292459:STH_RS11800
uniprot id: Q67LU5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

292459:STH RS09475
gene id: 292459:STH_RS09475
uniprot id: Q67N73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
messages: Cytoplasm
messages: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.

292459:STH RS03325
gene id: 292459:STH_RS03325
uniprot id: Q67RR2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

292459:STH RS09805
gene id: 292459:STH_RS09805
uniprot id: Q67N06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

292459:STH RS14970
gene id: 292459:STH_RS14970
uniprot id: Q67K06
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

292459:STH RS00650
gene id: 292459:STH_RS00650
uniprot id: Q67T86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

292459:STH RS01845
gene id: 292459:STH_RS01845
uniprot id: Q67SK8
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS15830
gene id: 292459:STH_RS15830
uniprot id: Q67JI4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

292459:STH RS09395
gene id: 292459:STH_RS09395
uniprot id: Q67N89
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS00715
gene id: 292459:STH_RS00715
uniprot id: Q67T73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

292459:STH RS08075
gene id: 292459:STH_RS08075
uniprot id: Q67P07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

292459:STH RS09240
gene id: 292459:STH_RS09240
uniprot id: Q67NC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

292459:STH RS05755
gene id: 292459:STH_RS05755
uniprot id: Q67QD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

292459:STH RS09460
gene id: 292459:STH_RS09460
uniprot id: Q67N76
names: Similarity
messages: Belongs to the Fur family.

292459:STH RS15455
gene id: 292459:STH_RS15455
uniprot id: Q67R61
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS01270
gene id: 292459:STH_RS01270
uniprot id: Q67SW1
names: Similarity
messages: Belongs to the thioredoxin family.

292459:STH RS15005
gene id: 292459:STH_RS15005
uniprot id: Q67JZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

292459:STH RS10235
gene id: 292459:STH_RS10235
uniprot id: Q67MS0
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

292459:STH RS02285
gene id: 292459:STH_RS02285
uniprot id: Q67SC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

292459:STH RS00085
gene id: 292459:STH_RS00085
uniprot id: Q67TJ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

292459:STH RS03300
gene id: 292459:STH_RS03300
uniprot id: Q67RR7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

292459:STH RS08860
gene id: 292459:STH_RS08860
uniprot id: Q67NJ7
names: Caution
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
messages: In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.
messages: In the N-terminal section; belongs to the MsrA Met sulfoxide reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

292459:STH RS02790
gene id: 292459:STH_RS02790
uniprot id: Q67S19
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

292459:STH RS07310
gene id: 292459:STH_RS07310
uniprot id: Q67PG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

292459:STH RS09100
gene id: 292459:STH_RS09100
uniprot id: Q67NF0
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS10850
gene id: 292459:STH_RS10850
uniprot id: Q67ME5
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

292459:STH RS15875
gene id: 292459:STH_RS15875
uniprot id: Q67JH5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm

292459:STH RS06860
gene id: 292459:STH_RS06860
uniprot id: Q67PQ4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

292459:STH RS08050
gene id: 292459:STH_RS08050
uniprot id: Q67P12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

292459:STH RS09385
gene id: 292459:STH_RS09385
uniprot id: Q67N91
names: Similarity
messages: Belongs to the UPF0236 family.

292459:STH RS03800
gene id: 292459:STH_RS03800
uniprot id: Q67QD4
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS08135
gene id: 292459:STH_RS08135
uniprot id: Q67NZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

292459:STH RS14815
gene id: 292459:STH_RS14815
uniprot id: Q67K35
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

292459:STH RS04165
gene id: 292459:STH_RS04165
uniprot id: Q67RA5
names: Similarity
messages: Belongs to the leucine-binding protein family.

292459:STH RS04400
gene id: 292459:STH_RS04400
uniprot id: Q67R57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

292459:STH RS06370
gene id: 292459:STH_RS06370
uniprot id: Q67Q09
names: Subcellular Location Annotation
messages: Cytoplasm

292459:STH RS04655
gene id: 292459:STH_RS04655
uniprot id: Q67R02
names: Similarity
messages: Belongs to the peptidase S9C family.

292459:STH RS06835
gene id: 292459:STH_RS06835
uniprot id: Q67PQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusB family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

292459:STH RS11795
gene id: 292459:STH_RS11795
uniprot id: Q67LU6
names: Subcellular Location Annotation
messages: Cell membrane

292459:STH RS02440
gene id: 292459:STH_RS02440
uniprot id: Q67S89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS02475
gene id: 292459:STH_RS02475
uniprot id: Q67S82
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

292459:STH RS19165
gene id: 292459:STH_RS19165
uniprot id: Q67N16
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS15335
gene id: 292459:STH_RS15335
uniprot id: Q67JT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

292459:STH RS14285
gene id: 292459:STH_RS14285
uniprot id: Q67KE3
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

292459:STH RS14195
gene id: 292459:STH_RS14195
uniprot id: Q67KG1
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

292459:STH RS05350
gene id: 292459:STH_RS05350
uniprot id: Q67QL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

292459:STH RS12475
gene id: 292459:STH_RS12475
uniprot id: Q67LF3
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

292459:STH RS05830
gene id: 292459:STH_RS05830
uniprot id: Q67QB6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

292459:STH RS01165
gene id: 292459:STH_RS01165
uniprot id: Q67SY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

292459:STH RS10015
gene id: 292459:STH_RS10015
uniprot id: Q67MW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF nuclease family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

292459:STH RS13250
gene id: 292459:STH_RS13250
uniprot id: Q67KZ5
names: Similarity
messages: Belongs to the Nth/MutY family.

292459:STH RS05355
gene id: 292459:STH_RS05355
uniprot id: Q67QL1
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

292459:STH RS12100
gene id: 292459:STH_RS12100
uniprot id: Q67LN0
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS06295
gene id: 292459:STH_RS06295
uniprot id: Q67Q24
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS16560
gene id: 292459:STH_RS16560
uniprot id: Q67J46
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS11525
gene id: 292459:STH_RS11525
uniprot id: Q67LZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS13055
gene id: 292459:STH_RS13055
uniprot id: Q67L36
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

292459:STH RS15780
gene id: 292459:STH_RS15780
uniprot id: Q67JJ4
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

292459:STH RS04675
gene id: 292459:STH_RS04675
uniprot id: Q67QZ7
names: Similarity
messages: Belongs to the UPF0162 family.

292459:STH RS13375
gene id: 292459:STH_RS13375
uniprot id: Q67KX0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS03205
gene id: 292459:STH_RS03205
uniprot id: Q67RT5
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS08740
gene id: 292459:STH_RS08740
uniprot id: Q67NM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

292459:STH RS02045
gene id: 292459:STH_RS02045
uniprot id: Q67SG8
names: Similarity
messages: Belongs to the GSP E family.

292459:STH RS09640
gene id: 292459:STH_RS09640
uniprot id: Q67N39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

292459:STH RS14485
gene id: 292459:STH_RS14485
uniprot id: Q67KA3
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

292459:STH RS14320
gene id: 292459:STH_RS14320
uniprot id: Q67KD6
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

292459:STH RS06690
gene id: 292459:STH_RS06690
uniprot id: Q67PU0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

292459:STH RS08800
gene id: 292459:STH_RS08800
uniprot id: Q67NL0
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

292459:STH RS17045
gene id: 292459:STH_RS17045
uniprot id: Q67Q44
names: Similarity
messages: Belongs to the diacylglycerol/lipid kinase family.

292459:STH RS14200
gene id: 292459:STH_RS14200
uniprot id: Q67KG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

292459:STH RS09305
gene id: 292459:STH_RS09305
uniprot id: Q67NA7
names: Similarity
messages: Belongs to the asp23 family.

292459:STH RS05105
gene id: 292459:STH_RS05105
uniprot id: Q67QR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

292459:STH RS04660
gene id: 292459:STH_RS04660
uniprot id: Q67R01
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

292459:STH RS07525
gene id: 292459:STH_RS07525
uniprot id: Q67PB7
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

292459:STH RS05945
gene id: 292459:STH_RS05945
uniprot id: Q67Q92
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

292459:STH RS07530
gene id: 292459:STH_RS07530
uniprot id: Q67PB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

292459:STH RS14770
gene id: 292459:STH_RS14770
uniprot id: Q67K44
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

292459:STH RS14545
gene id: 292459:STH_RS14545
uniprot id: Q67R61
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS16635
gene id: 292459:STH_RS16635
uniprot id: Q67J29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

292459:STH RS15100
gene id: 292459:STH_RS15100
uniprot id: Q67JX9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

292459:STH RS07980
gene id: 292459:STH_RS07980
uniprot id: Q67P26
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

292459:STH RS07210
gene id: 292459:STH_RS07210
uniprot id: Q67PI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diaminopimelate dehydrogenase family.
messages: Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate.
messages: Homodimer.

292459:STH RS13200
gene id: 292459:STH_RS13200
uniprot id: Q67L07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS13355
gene id: 292459:STH_RS13355
uniprot id: Q67KX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

292459:STH RS05080
gene id: 292459:STH_RS05080
uniprot id: Q67QR6
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

292459:STH RS13965
gene id: 292459:STH_RS13965
uniprot id: Q67KK5
names: Similarity
messages: Belongs to the peptidase S66 family.

292459:STH RS15215
gene id: 292459:STH_RS15215
uniprot id: Q67JV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

292459:STH RS07765
gene id: 292459:STH_RS07765
uniprot id: Q67P68
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS12650
gene id: 292459:STH_RS12650
uniprot id: Q67LB8
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

292459:STH RS10330
gene id: 292459:STH_RS10330
uniprot id: Q67R61
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS10990
gene id: 292459:STH_RS10990
uniprot id: Q67MB3
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS07325
gene id: 292459:STH_RS07325
uniprot id: Q67PF8
names: Similarity
messages: Belongs to the fabD family.

292459:STH RS02920
gene id: 292459:STH_RS02920
uniprot id: Q67RZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

292459:STH RS14775
gene id: 292459:STH_RS14775
uniprot id: Q67K43
names: Similarity
messages: Belongs to the MotB family.

292459:STH RS02310
gene id: 292459:STH_RS02310
uniprot id: Q67SB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

292459:STH RS00760
gene id: 292459:STH_RS00760
uniprot id: Q67T64
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

292459:STH RS06345
gene id: 292459:STH_RS06345
uniprot id: Q67Q14
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

292459:STH RS09965
gene id: 292459:STH_RS09965
uniprot id: Q67MX1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

292459:STH RS06460
gene id: 292459:STH_RS06460
uniprot id: Q67PZ1
names: Cofactor
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

292459:STH RS04085
gene id: 292459:STH_RS04085
uniprot id: Q67RC2
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. NagD family.
messages: Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro.

292459:STH RS07260
gene id: 292459:STH_RS07260
uniprot id: Q67PH3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

292459:STH RS14330
gene id: 292459:STH_RS14330
uniprot id: Q67KD4
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

292459:STH RS15255
gene id: 292459:STH_RS15255
uniprot id: Q67JU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

292459:STH RS00235
gene id: 292459:STH_RS00235
uniprot id: Q67TH5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

292459:STH RS09065
gene id: 292459:STH_RS09065
uniprot id: Q67NF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpB family.
messages: Cytoplasm
messages: Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.

292459:STH RS07760
gene id: 292459:STH_RS07760
uniprot id: Q67P69
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

292459:STH RS06510
gene id: 292459:STH_RS06510
uniprot id: Q67PY2
names: Subcellular Location Annotation
messages: Cytoplasm

292459:STH RS07035
gene id: 292459:STH_RS07035
uniprot id: Q67PL8
names: Similarity
messages: Belongs to the peptidase C56 family.

292459:STH RS13815
gene id: 292459:STH_RS13815
uniprot id: Q67KN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

292459:STH RS12755
gene id: 292459:STH_RS12755
uniprot id: Q67L97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

292459:STH RS08195
gene id: 292459:STH_RS08195
uniprot id: Q67NY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

292459:STH RS14300
gene id: 292459:STH_RS14300
uniprot id: Q67KE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

292459:STH RS05535
gene id: 292459:STH_RS05535
uniprot id: Q67QH4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

292459:STH RS06340
gene id: 292459:STH_RS06340
uniprot id: Q67Q15
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

292459:STH RS05525
gene id: 292459:STH_RS05525
uniprot id: Q67QH6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

292459:STH RS03575
gene id: 292459:STH_RS03575
uniprot id: Q67RL0
names: Similarity
messages: Belongs to the UPF0312 family.

292459:STH RS04620
gene id: 292459:STH_RS04620
uniprot id: Q67R10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

292459:STH RS15130
gene id: 292459:STH_RS15130
uniprot id: Q67JX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).

292459:STH RS11055
gene id: 292459:STH_RS11055
uniprot id: Q67MA0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

292459:STH RS14945
gene id: 292459:STH_RS14945
uniprot id: Q67K11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

292459:STH RS16280
gene id: 292459:STH_RS16280
uniprot id: Q67JA0
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

292459:STH RS15170
gene id: 292459:STH_RS15170
uniprot id: Q67JW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

292459:STH RS14610
gene id: 292459:STH_RS14610
uniprot id: Q67K78
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

292459:STH RS14690
gene id: 292459:STH_RS14690
uniprot id: Q67R61
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS03535
gene id: 292459:STH_RS03535
uniprot id: Q67RL8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS14415
gene id: 292459:STH_RS14415
uniprot id: Q67KB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

292459:STH RS16610
gene id: 292459:STH_RS16610
uniprot id: Q67J34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

292459:STH RS17530
gene id: 292459:STH_RS17530
uniprot id: Q67KP1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

292459:STH RS15855
gene id: 292459:STH_RS15855
uniprot id: Q67JH9
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

292459:STH RS15545
gene id: 292459:STH_RS15545
uniprot id: Q67JP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DisA family.
messages: Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
messages: Homooctamer.
messages: Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation.

292459:STH RS02545
gene id: 292459:STH_RS02545
uniprot id: Q67S68
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

292459:STH RS15550
gene id: 292459:STH_RS15550
uniprot id: Q67JP0
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

292459:STH RS09090
gene id: 292459:STH_RS09090
uniprot id: Q67NF2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

292459:STH RS04300
gene id: 292459:STH_RS04300
uniprot id: Q67R76
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family. L-methionine gamma-lyase subfamily.

292459:STH RS07145
gene id: 292459:STH_RS07145
uniprot id: Q67PJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

292459:STH RS07815
gene id: 292459:STH_RS07815
uniprot id: Q67R61
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS14280
gene id: 292459:STH_RS14280
uniprot id: Q67KE4
names: Similarity
messages: Belongs to the thioredoxin family.

292459:STH RS01755
gene id: 292459:STH_RS01755
uniprot id: Q67SL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

292459:STH RS14505
gene id: 292459:STH_RS14505
uniprot id: Q67K99
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

292459:STH RS16420
gene id: 292459:STH_RS16420
uniprot id: Q67J72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

292459:STH RS14355
gene id: 292459:STH_RS14355
uniprot id: Q67KC9
names: Similarity
messages: Belongs to the AOR/FOR family.

292459:STH RS11500
gene id: 292459:STH_RS11500
uniprot id: Q67M03
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS09275
gene id: 292459:STH_RS09275
uniprot id: Q67NB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

292459:STH RS11785
gene id: 292459:STH_RS11785
uniprot id: Q67LU8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

292459:STH RS08000
gene id: 292459:STH_RS08000
uniprot id: Q67P22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

292459:STH RS12595
gene id: 292459:STH_RS12595
uniprot id: Q67LC9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

292459:STH RS05575
gene id: 292459:STH_RS05575
uniprot id: Q67QG6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

292459:STH RS04505
gene id: 292459:STH_RS04505
uniprot id: Q67R33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS00070
gene id: 292459:STH_RS00070
uniprot id: Q67TJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

292459:STH RS00425
gene id: 292459:STH_RS00425
uniprot id: Q67TD2
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

292459:STH RS14305
gene id: 292459:STH_RS14305
uniprot id: Q67KD9
names: Similarity
messages: Belongs to the Fur family.

292459:STH RS07535
gene id: 292459:STH_RS07535
uniprot id: Q67PB5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.

292459:STH RS14665
gene id: 292459:STH_RS14665
uniprot id: Q67K67
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

292459:STH RS16335
gene id: 292459:STH_RS16335
uniprot id: Q67J89
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

292459:STH RS07125
gene id: 292459:STH_RS07125
uniprot id: Q67PK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

292459:STH RS06530
gene id: 292459:STH_RS06530
uniprot id: Q67PX8
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

292459:STH RS01910
gene id: 292459:STH_RS01910
uniprot id: Q67SJ5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

292459:STH RS02525
gene id: 292459:STH_RS02525
uniprot id: Q67S72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

292459:STH RS15325
gene id: 292459:STH_RS15325
uniprot id: Q67JT4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

292459:STH RS05820
gene id: 292459:STH_RS05820
uniprot id: Q67QB8
names: Subcellular Location Annotation
messages: Cell membrane

292459:STH RS14985
gene id: 292459:STH_RS14985
uniprot id: Q67K03
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

292459:STH RS16205
gene id: 292459:STH_RS16205
uniprot id: Q67JB6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

292459:STH RS14595
gene id: 292459:STH_RS14595
uniprot id: Q67K81
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

292459:STH RS00020
gene id: 292459:STH_RS00020
uniprot id: Q67TK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

292459:STH RS15085
gene id: 292459:STH_RS15085
uniprot id: Q67JY2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

292459:STH RS13570
gene id: 292459:STH_RS13570
uniprot id: Q67KS1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

292459:STH RS00395
gene id: 292459:STH_RS00395
uniprot id: Q67TD8
names: Similarity
messages: Belongs to the peptidase S45 family.

292459:STH RS02630
gene id: 292459:STH_RS02630
uniprot id: Q67S51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

292459:STH RS02750
gene id: 292459:STH_RS02750
uniprot id: Q67S27
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

292459:STH RS08815
gene id: 292459:STH_RS08815
uniprot id: Q67NK7
names: Similarity
messages: Belongs to the EamA transporter family.

292459:STH RS11115
gene id: 292459:STH_RS11115
uniprot id: Q67M87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

292459:STH RS00470
gene id: 292459:STH_RS00470
uniprot id: Q67TC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.

292459:STH RS04890
gene id: 292459:STH_RS04890
uniprot id: Q67QV4
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

292459:STH RS14500
gene id: 292459:STH_RS14500
uniprot id: Q67KA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

292459:STH RS15425
gene id: 292459:STH_RS15425
uniprot id: Q67JR5
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

292459:STH RS08455
gene id: 292459:STH_RS08455
uniprot id: Q67NS9
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

292459:STH RS14885
gene id: 292459:STH_RS14885
uniprot id: Q67K23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

292459:STH RS00165
gene id: 292459:STH_RS00165
uniprot id: Q67TJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

292459:STH RS02665
gene id: 292459:STH_RS02665
uniprot id: Q67S44
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

292459:STH RS07315
gene id: 292459:STH_RS07315
uniprot id: Q67PG0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

292459:STH RS08320
gene id: 292459:STH_RS08320
uniprot id: Q67NV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS12160
gene id: 292459:STH_RS12160
uniprot id: Q67LL8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

292459:STH RS07020
gene id: 292459:STH_RS07020
uniprot id: Q67PM1
names: Similarity
messages: Belongs to the PspA/IM30 family.

292459:STH RS02295
gene id: 292459:STH_RS02295
uniprot id: P31015
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the beta-eliminating lyase family.
messages: Homotetramer.
messages: Tna2 is expressed in strain T but expression in strain IAM 13621 has not been proven.

292459:STH RS09645
gene id: 292459:STH_RS09645
uniprot id: Q67N38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

292459:STH RS16605
gene id: 292459:STH_RS16605
uniprot id: Q67J35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

292459:STH RS00375
gene id: 292459:STH_RS00375
uniprot id: Q67TE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

292459:STH RS16090
gene id: 292459:STH_RS16090
uniprot id: Q67JD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

292459:STH RS01890
gene id: 292459:STH_RS01890
uniprot id: Q67SJ9
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

292459:STH RS10925
gene id: 292459:STH_RS10925
uniprot id: Q67MC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS01885
gene id: 292459:STH_RS01885
uniprot id: Q67SK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

292459:STH RS14120
gene id: 292459:STH_RS14120
uniprot id: Q67KH6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

292459:STH RS10080
gene id: 292459:STH_RS10080
uniprot id: Q67MV1
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS01190
gene id: 292459:STH_RS01190
uniprot id: Q67SX7
names: Similarity
messages: Belongs to the asparagine synthetase family.

292459:STH RS14865
gene id: 292459:STH_RS14865
uniprot id: Q3V816
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

292459:STH RS12615
gene id: 292459:STH_RS12615
uniprot id: Q67LC5
names: Similarity
messages: Belongs to the class-I fumarase family.

292459:STH RS13260
gene id: 292459:STH_RS13260
uniprot id: Q67KZ3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

292459:STH RS08430
gene id: 292459:STH_RS08430
uniprot id: Q67NT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

292459:STH RS05655
gene id: 292459:STH_RS05655
uniprot id: Q67QE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

292459:STH RS13735
gene id: 292459:STH_RS13735
uniprot id: Q67KQ2
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

292459:STH RS15920
gene id: 292459:STH_RS15920
uniprot id: Q67JG7
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

292459:STH RS10905
gene id: 292459:STH_RS10905
uniprot id: Q67MD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

292459:STH RS14110
gene id: 292459:STH_RS14110
uniprot id: Q67KH8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

292459:STH RS13330
gene id: 292459:STH_RS13330
uniprot id: Q67KX9
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

292459:STH RS15330
gene id: 292459:STH_RS15330
uniprot id: Q67JT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

292459:STH RS15285
gene id: 292459:STH_RS15285
uniprot id: Q67JU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

292459:STH RS15245
gene id: 292459:STH_RS15245
uniprot id: Q67JV1
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

292459:STH RS16285
gene id: 292459:STH_RS16285
uniprot id: Q67J99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

292459:STH RS16540
gene id: 292459:STH_RS16540
uniprot id: Q67J50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

292459:STH RS10405
gene id: 292459:STH_RS10405
uniprot id: Q67MN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

292459:STH RS04770
gene id: 292459:STH_RS04770
uniprot id: Q67QX8
names: Similarity
messages: Belongs to the glutamate synthase family.

292459:STH RS02765
gene id: 292459:STH_RS02765
uniprot id: Q67S24
names: Function
names: Similarity
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Monomer.

292459:STH RS12810
gene id: 292459:STH_RS12810
uniprot id: Q67L86
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

292459:STH RS15565
gene id: 292459:STH_RS15565
uniprot id: Q67JN7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

292459:STH RS01970
gene id: 292459:STH_RS01970
uniprot id: Q67SI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

292459:STH RS17030
gene id: 292459:STH_RS17030
uniprot id: Q67Q83
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

292459:STH RS04670
gene id: 292459:STH_RS04670
uniprot id: Q67QZ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

292459:STH RS01760
gene id: 292459:STH_RS01760
uniprot id: Q67SL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

292459:STH RS03195
gene id: 292459:STH_RS03195
uniprot id: Q67RT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease PrsW family.
messages: Cell membrane
messages: Membrane

292459:STH RS12885
gene id: 292459:STH_RS12885
uniprot id: Q67L72
names: Function
names: Similarity
messages: Belongs to the BshC family.
messages: Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH.

292459:STH RS04625
gene id: 292459:STH_RS04625
uniprot id: Q67R09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

292459:STH RS04895
gene id: 292459:STH_RS04895
uniprot id: Q67QV3
names: Function
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

292459:STH RS15575
gene id: 292459:STH_RS15575
uniprot id: Q67JN5
names: Similarity
messages: Belongs to the ClpA/ClpB family.

292459:STH RS14825
gene id: 292459:STH_RS14825
uniprot id: Q67K33
names: Similarity
messages: Belongs to the FlgM family.

292459:STH RS05120
gene id: 292459:STH_RS05120
uniprot id: Q67QQ8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

292459:STH RS14910
gene id: 292459:STH_RS14910
uniprot id: Q67K18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

292459:STH RS13880
gene id: 292459:STH_RS13880
uniprot id: Q67KM2
names: Subcellular Location Annotation
messages: Membrane

292459:STH RS12730
gene id: 292459:STH_RS12730
uniprot id: Q67R61
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

292459:STH RS07995
gene id: 292459:STH_RS07995
uniprot id: Q67P23
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

292459:STH RS09130
gene id: 292459:STH_RS09130
uniprot id: Q67NE4
names: Function
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.
messages: In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition.

292459:STH RS11955
gene id: 292459:STH_RS11955
uniprot id: Q67LR3
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

292459:STH RS08530
gene id: 292459:STH_RS08530
uniprot id: Q67NR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

292459:STH RS02615
gene id: 292459:STH_RS02615
uniprot id: Q67S54
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

292459:STH RS13740
gene id: 292459:STH_RS13740
uniprot id: Q67KQ1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

292459:STH RS14950
gene id: 292459:STH_RS14950
uniprot id: Q67K10
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.