289377:HL41 RS05760
gene id: 289377:HL41_RS05760
uniprot id: A0A075WSS1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

289377:HL41 RS06325
gene id: 289377:HL41_RS06325
uniprot id: A0A075X093
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS00440
gene id: 289377:HL41_RS00440
uniprot id: A0A075WQ02
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

289377:HL41 RS05575
gene id: 289377:HL41_RS05575
uniprot id: A0A075WV21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

289377:HL41 RS05200
gene id: 289377:HL41_RS05200
uniprot id: A0A075WT84
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

289377:HL41 RS00615
gene id: 289377:HL41_RS00615
uniprot id: A0A075WR77
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS08615
gene id: 289377:HL41_RS08615
uniprot id: A0A075WV30
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

289377:HL41 RS02935
gene id: 289377:HL41_RS02935
uniprot id: A0A075WRA4
names: Similarity
messages: Belongs to the UPF0111 family.

289377:HL41 RS01540
gene id: 289377:HL41_RS01540
uniprot id: A0A075WYE6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

289377:HL41 RS03910
gene id: 289377:HL41_RS03910
uniprot id: A0A075WUC6
names: Similarity
messages: Belongs to the TrpC family.

289377:HL41 RS00985
gene id: 289377:HL41_RS00985
uniprot id: A0A075WRN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

289377:HL41 RS03190
gene id: 289377:HL41_RS03190
uniprot id: A0A075WSP4
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

289377:HL41 RS07485
gene id: 289377:HL41_RS07485
uniprot id: A0A075WVU3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS01050
gene id: 289377:HL41_RS01050
uniprot id: A0A075WT00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

289377:HL41 RS03930
gene id: 289377:HL41_RS03930
uniprot id: A0A075WT17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

289377:HL41 RS08650
gene id: 289377:HL41_RS08650
uniprot id: A0A075WW94
names: Similarity
messages: Belongs to the FlgM family.

289377:HL41 RS04975
gene id: 289377:HL41_RS04975
uniprot id: A0A075WSE8
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

289377:HL41 RS01265
gene id: 289377:HL41_RS01265
uniprot id: A0A075WRX0
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

289377:HL41 RS02210
gene id: 289377:HL41_RS02210
uniprot id: A0A075WQY1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

289377:HL41 RS04620
gene id: 289377:HL41_RS04620
uniprot id: A0A075WS94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

289377:HL41 RS05860
gene id: 289377:HL41_RS05860
uniprot id: A0A075WST1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

289377:HL41 RS03980
gene id: 289377:HL41_RS03980
uniprot id: A0A075WT26
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS06175
gene id: 289377:HL41_RS06175
uniprot id: A0A075WVA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

289377:HL41 RS03940
gene id: 289377:HL41_RS03940
uniprot id: A0A075WUC9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS02205
gene id: 289377:HL41_RS02205
uniprot id: A0A075WTK1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

289377:HL41 RS02525
gene id: 289377:HL41_RS02525
uniprot id: A0A075WRW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

289377:HL41 RS02690
gene id: 289377:HL41_RS02690
uniprot id: A0A075WYR9
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS05785
gene id: 289377:HL41_RS05785
uniprot id: A0A075WTX0
names: Similarity
messages: Belongs to the OprB family.

289377:HL41 RS05845
gene id: 289377:HL41_RS05845
uniprot id: A0A075WTX9
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

289377:HL41 RS02790
gene id: 289377:HL41_RS02790
uniprot id: A0A075WR81
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

289377:HL41 RS08590
gene id: 289377:HL41_RS08590
uniprot id: A0A075WV27
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

289377:HL41 RS01890
gene id: 289377:HL41_RS01890
uniprot id: A0A075WYH6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

289377:HL41 RS04590
gene id: 289377:HL41_RS04590
uniprot id: A0A075WS89
names: Similarity
messages: Belongs to the MEMO1 family.

289377:HL41 RS04585
gene id: 289377:HL41_RS04585
uniprot id: A0A075WUN1
names: Similarity
messages: Belongs to the TrpF family.

289377:HL41 RS05190
gene id: 289377:HL41_RS05190
uniprot id: A0A075WUW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

289377:HL41 RS04545
gene id: 289377:HL41_RS04545
uniprot id: A0A075WT03
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

289377:HL41 RS08800
gene id: 289377:HL41_RS08800
uniprot id: A0A075WTA2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS06460
gene id: 289377:HL41_RS06460
uniprot id: A0A075WU68
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

289377:HL41 RS05235
gene id: 289377:HL41_RS05235
uniprot id: A0A075WZV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

289377:HL41 RS00770
gene id: 289377:HL41_RS00770
uniprot id: A0A075WY20
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS06425
gene id: 289377:HL41_RS06425
uniprot id: A0A075WTA2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS01970
gene id: 289377:HL41_RS01970
uniprot id: A0A075WYI4
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

289377:HL41 RS03430
gene id: 289377:HL41_RS03430
uniprot id: A0A075WSC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

289377:HL41 RS01405
gene id: 289377:HL41_RS01405
uniprot id: A0A075WQK6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

289377:HL41 RS01310
gene id: 289377:HL41_RS01310
uniprot id: A0A075WRJ0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS05405
gene id: 289377:HL41_RS05405
uniprot id: A0A075WTR1
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

289377:HL41 RS00830
gene id: 289377:HL41_RS00830
uniprot id: A0A075WQ74
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

289377:HL41 RS01295
gene id: 289377:HL41_RS01295
uniprot id: A0A075WYC2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

289377:HL41 RS03505
gene id: 289377:HL41_RS03505
uniprot id: A0A075WU65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

289377:HL41 RS07390
gene id: 289377:HL41_RS07390
uniprot id: A0A075X0S0
names: Similarity
messages: Belongs to the peptidase M16 family.

289377:HL41 RS04820
gene id: 289377:HL41_RS04820
uniprot id: A0A075WZQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Membrane

289377:HL41 RS01320
gene id: 289377:HL41_RS01320
uniprot id: A0A075WYC7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

289377:HL41 RS03245
gene id: 289377:HL41_RS03245
uniprot id: A0A075WS91
names: Similarity
messages: Belongs to the universal stress protein A family.

289377:HL41 RS01065
gene id: 289377:HL41_RS01065
uniprot id: A0A075WRQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

289377:HL41 RS08480
gene id: 289377:HL41_RS08480
uniprot id: A0A075WTZ2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS00150
gene id: 289377:HL41_RS00150
uniprot id: A0A075WSI9
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS05455
gene id: 289377:HL41_RS05455
uniprot id: A0A075WTS1
names: Similarity
messages: Belongs to the band 7/mec-2 family.

289377:HL41 RS01365
gene id: 289377:HL41_RS01365
uniprot id: A0A075WT92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

289377:HL41 RS00100
gene id: 289377:HL41_RS00100
uniprot id: A0A075WQY3
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS02160
gene id: 289377:HL41_RS02160
uniprot id: A0A075WS75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

289377:HL41 RS04765
gene id: 289377:HL41_RS04765
uniprot id: A0A075WTG7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

289377:HL41 RS07700
gene id: 289377:HL41_RS07700
uniprot id: A0A075WUJ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

289377:HL41 RS06415
gene id: 289377:HL41_RS06415
uniprot id: A0A075WVC5
names: Similarity
messages: Belongs to the peptidase S49 family.

289377:HL41 RS06915
gene id: 289377:HL41_RS06915
uniprot id: A0A075WU46
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

289377:HL41 RS00580
gene id: 289377:HL41_RS00580
uniprot id: A0A075WR74
names: Similarity
messages: Belongs to the WrbA family.

289377:HL41 RS03510
gene id: 289377:HL41_RS03510
uniprot id: A0A075WRJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

289377:HL41 RS01185
gene id: 289377:HL41_RS01185
uniprot id: A0A075WYA5
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

289377:HL41 RS02030
gene id: 289377:HL41_RS02030
uniprot id: A0A075WS61
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS00975
gene id: 289377:HL41_RS00975
uniprot id: A0A075WQA3
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS06265
gene id: 289377:HL41_RS06265
uniprot id: A0A075WU37
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

289377:HL41 RS03520
gene id: 289377:HL41_RS03520
uniprot id: A0A075WSU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

289377:HL41 RS05060
gene id: 289377:HL41_RS05060
uniprot id: A0A075WTK4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS01195
gene id: 289377:HL41_RS01195
uniprot id: A0A075WQH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

289377:HL41 RS07360
gene id: 289377:HL41_RS07360
uniprot id: A0A075X0R6
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

289377:HL41 RS02410
gene id: 289377:HL41_RS02410
uniprot id: A0A075WYN3
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS02310
gene id: 289377:HL41_RS02310
uniprot id: A0A075WQZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

289377:HL41 RS01610
gene id: 289377:HL41_RS01610
uniprot id: A0A075WRL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

289377:HL41 RS05375
gene id: 289377:HL41_RS05375
uniprot id: A0A075WTQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm

289377:HL41 RS05290
gene id: 289377:HL41_RS05290
uniprot id: A0A075WUX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

289377:HL41 RS03615
gene id: 289377:HL41_RS03615
uniprot id: A0A075WU86
names: Similarity
messages: Belongs to the DEAD box helicase family.

289377:HL41 RS02280
gene id: 289377:HL41_RS02280
uniprot id: A0A075WTL2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

289377:HL41 RS02275
gene id: 289377:HL41_RS02275
uniprot id: A0A075WYL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

289377:HL41 RS08585
gene id: 289377:HL41_RS08585
uniprot id: A0A075WUW4
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

289377:HL41 RS07850
gene id: 289377:HL41_RS07850
uniprot id: A0A075WUL1
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

289377:HL41 RS03865
gene id: 289377:HL41_RS03865
uniprot id: A0A075WSK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

289377:HL41 RS00710
gene id: 289377:HL41_RS00710
uniprot id: A0A075WY11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

289377:HL41 RS06165
gene id: 289377:HL41_RS06165
uniprot id: A0A075WU27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

289377:HL41 RS05135
gene id: 289377:HL41_RS05135
uniprot id: A0A075WZT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

289377:HL41 RS02750
gene id: 289377:HL41_RS02750
uniprot id: A0A075WYS6
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

289377:HL41 RS08470
gene id: 289377:HL41_RS08470
uniprot id: A0A075X160
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

289377:HL41 RS05295
gene id: 289377:HL41_RS05295
uniprot id: A0A075WSK5
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

289377:HL41 RS01055
gene id: 289377:HL41_RS01055
uniprot id: A0A075WQB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

289377:HL41 RS03035
gene id: 289377:HL41_RS03035
uniprot id: A0A075WTZ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

289377:HL41 RS00510
gene id: 289377:HL41_RS00510
uniprot id: A0A075WXY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

289377:HL41 RS04770
gene id: 289377:HL41_RS04770
uniprot id: A0A075WZQ2
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

289377:HL41 RS08565
gene id: 289377:HL41_RS08565
uniprot id: A0A075WW80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

289377:HL41 RS04120
gene id: 289377:HL41_RS04120
uniprot id: A0A075WT55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

289377:HL41 RS00445
gene id: 289377:HL41_RS00445
uniprot id: A0A075WR49
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

289377:HL41 RS02590
gene id: 289377:HL41_RS02590
uniprot id: A0A075WRX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

289377:HL41 RS05220
gene id: 289377:HL41_RS05220
uniprot id: A0A075WSJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

289377:HL41 RS05250
gene id: 289377:HL41_RS05250
uniprot id: A0A075WT93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

289377:HL41 RS03405
gene id: 289377:HL41_RS03405
uniprot id: A0A075WSS8
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

289377:HL41 RS08285
gene id: 289377:HL41_RS08285
uniprot id: A0A075X138
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

289377:HL41 RS05925
gene id: 289377:HL41_RS05925
uniprot id: A0A075WST7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

289377:HL41 RS00035
gene id: 289377:HL41_RS00035
uniprot id: A0A075WQX5
names: Similarity
messages: Belongs to the peptidase A31 family.

289377:HL41 RS08315
gene id: 289377:HL41_RS08315
uniprot id: A0A075X143
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS02315
gene id: 289377:HL41_RS02315
uniprot id: A0A075WRT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

289377:HL41 RS05470
gene id: 289377:HL41_RS05470
uniprot id: A0A075WSN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

289377:HL41 RS02475
gene id: 289377:HL41_RS02475
uniprot id: A0A075WRW2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

289377:HL41 RS04600
gene id: 289377:HL41_RS04600
uniprot id: A0A075WTF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

289377:HL41 RS07090
gene id: 289377:HL41_RS07090
uniprot id: A0A075X0K4
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS02940
gene id: 289377:HL41_RS02940
uniprot id: A0A075WS34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

289377:HL41 RS05130
gene id: 289377:HL41_RS05130
uniprot id: A0A075WTL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

289377:HL41 RS00575
gene id: 289377:HL41_RS00575
uniprot id: A0A075WQ31
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

289377:HL41 RS00785
gene id: 289377:HL41_RS00785
uniprot id: A0A075WRA6
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

289377:HL41 RS01790
gene id: 289377:HL41_RS01790
uniprot id: A0A075WYG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

289377:HL41 RS00530
gene id: 289377:HL41_RS00530
uniprot id: A0A075WRE7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

289377:HL41 RS07770
gene id: 289377:HL41_RS07770
uniprot id: A0A075WVX2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

289377:HL41 RS00680
gene id: 289377:HL41_RS00680
uniprot id: A0A075WRH0
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

289377:HL41 RS06925
gene id: 289377:HL41_RS06925
uniprot id: A0A075X0H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

289377:HL41 RS06295
gene id: 289377:HL41_RS06295
uniprot id: A0A075X090
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

289377:HL41 RS05445
gene id: 289377:HL41_RS05445
uniprot id: A0A075WSM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

289377:HL41 RS06815
gene id: 289377:HL41_RS06815
uniprot id: A0A075WVH9
names: Similarity
messages: Belongs to the myoviridae tail sheath protein family.

289377:HL41 RS03020
gene id: 289377:HL41_RS03020
uniprot id: A0A075WS51
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

289377:HL41 RS03345
gene id: 289377:HL41_RS03345
uniprot id: A0A075WSA8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

289377:HL41 RS05145
gene id: 289377:HL41_RS05145
uniprot id: A0A075WSH4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

289377:HL41 RS03830
gene id: 289377:HL41_RS03830
uniprot id: A0A075WSK1
names: Similarity
messages: Belongs to the glutamine synthetase family.

289377:HL41 RS03530
gene id: 289377:HL41_RS03530
uniprot id: A0A075WU70
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

289377:HL41 RS03220
gene id: 289377:HL41_RS03220
uniprot id: A0A075WSQ0
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS00700
gene id: 289377:HL41_RS00700
uniprot id: A0A075WR89
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

289377:HL41 RS04235
gene id: 289377:HL41_RS04235
uniprot id: A0A075WTA2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS03525
gene id: 289377:HL41_RS03525
uniprot id: A0A075WZ36
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

289377:HL41 RS08110
gene id: 289377:HL41_RS08110
uniprot id: A0A075WUQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

289377:HL41 RS05865
gene id: 289377:HL41_RS05865
uniprot id: A0A075WTM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 5 family.
messages: Membrane

289377:HL41 RS09860
gene id: 289377:HL41_RS09860
uniprot id: A0A075WSI8
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

289377:HL41 RS07440
gene id: 289377:HL41_RS07440
uniprot id: A0A075X0S8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

289377:HL41 RS08570
gene id: 289377:HL41_RS08570
uniprot id: A0A075WU18
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

289377:HL41 RS01120
gene id: 289377:HL41_RS01120
uniprot id: A0A075WRR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

289377:HL41 RS08460
gene id: 289377:HL41_RS08460
uniprot id: A0A075WUU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

289377:HL41 RS03905
gene id: 289377:HL41_RS03905
uniprot id: A0A075WZA7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

289377:HL41 RS03705
gene id: 289377:HL41_RS03705
uniprot id: A0A075WUA1
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

289377:HL41 RS07875
gene id: 289377:HL41_RS07875
uniprot id: A0A075WUL7
names: Function
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

289377:HL41 RS07785
gene id: 289377:HL41_RS07785
uniprot id: A0A075WUK5
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

289377:HL41 RS01255
gene id: 289377:HL41_RS01255
uniprot id: A0A075WQI4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

289377:HL41 RS06520
gene id: 289377:HL41_RS06520
uniprot id: A0A075WVD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

289377:HL41 RS07905
gene id: 289377:HL41_RS07905
uniprot id: A0A075WUU4
names: Similarity
messages: Belongs to the universal stress protein A family.

289377:HL41 RS07170
gene id: 289377:HL41_RS07170
uniprot id: A0A075WU97
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

289377:HL41 RS03425
gene id: 289377:HL41_RS03425
uniprot id: A0A075WRI2
names: Similarity
messages: Belongs to the CutA family.

289377:HL41 RS06000
gene id: 289377:HL41_RS06000
uniprot id: A0A075WV72
names: Similarity
messages: Belongs to the thioredoxin family.

289377:HL41 RS08290
gene id: 289377:HL41_RS08290
uniprot id: A0A075WW39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

289377:HL41 RS00675
gene id: 289377:HL41_RS00675
uniprot id: A0A075WR85
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

289377:HL41 RS01090
gene id: 289377:HL41_RS01090
uniprot id: A0A075WRR0
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

289377:HL41 RS08295
gene id: 289377:HL41_RS08295
uniprot id: A0A075WTW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

289377:HL41 RS03475
gene id: 289377:HL41_RS03475
uniprot id: A0A075WZ30
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

289377:HL41 RS01100
gene id: 289377:HL41_RS01100
uniprot id: A0A075WY76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

289377:HL41 RS00720
gene id: 289377:HL41_RS00720
uniprot id: A0A075WQ54
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS01070
gene id: 289377:HL41_RS01070
uniprot id: A0A075WY72
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

289377:HL41 RS06985
gene id: 289377:HL41_RS06985
uniprot id: A0A075X0I3
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

289377:HL41 RS06035
gene id: 289377:HL41_RS06035
uniprot id: A0A075WV78
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

289377:HL41 RS00075
gene id: 289377:HL41_RS00075
uniprot id: A0A075WQY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

289377:HL41 RS08765
gene id: 289377:HL41_RS08765
uniprot id: A0A075WUY9
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

289377:HL41 RS05990
gene id: 289377:HL41_RS05990
uniprot id: A0A075WU03
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS03850
gene id: 289377:HL41_RS03850
uniprot id: A0A075WRR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

289377:HL41 RS02855
gene id: 289377:HL41_RS02855
uniprot id: A0A075WS18
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

289377:HL41 RS02195
gene id: 289377:HL41_RS02195
uniprot id: A0A075WS79
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS07380
gene id: 289377:HL41_RS07380
uniprot id: A0A075WUG8
names: Similarity
messages: Belongs to the bacterial glucokinase family.

289377:HL41 RS02555
gene id: 289377:HL41_RS02555
uniprot id: A0A075WSE2
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

289377:HL41 RS06250
gene id: 289377:HL41_RS06250
uniprot id: A0A075WVA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

289377:HL41 RS01955
gene id: 289377:HL41_RS01955
uniprot id: A0A075WQU8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS00625
gene id: 289377:HL41_RS00625
uniprot id: A0A075WRG3
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

289377:HL41 RS01660
gene id: 289377:HL41_RS01660
uniprot id: A0A075WQQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family.
messages: Cell outer membrane

289377:HL41 RS07140
gene id: 289377:HL41_RS07140
uniprot id: A0A075WUF4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

289377:HL41 RS08165
gene id: 289377:HL41_RS08165
uniprot id: A0A075WTT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

289377:HL41 RS00425
gene id: 289377:HL41_RS00425
uniprot id: A0A075WRC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

289377:HL41 RS01940
gene id: 289377:HL41_RS01940
uniprot id: A0A075WS53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

289377:HL41 RS02560
gene id: 289377:HL41_RS02560
uniprot id: A0A075WYQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

289377:HL41 RS01480
gene id: 289377:HL41_RS01480
uniprot id: A0A075WYE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

289377:HL41 RS01030
gene id: 289377:HL41_RS01030
uniprot id: A0A075WQB5
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS04835
gene id: 289377:HL41_RS04835
uniprot id: A0A075WT38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

289377:HL41 RS04070
gene id: 289377:HL41_RS04070
uniprot id: A0A075WUF2
names: Similarity
messages: Belongs to the Ahb/Nir family.

289377:HL41 RS02085
gene id: 289377:HL41_RS02085
uniprot id: A0A075WS68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

289377:HL41 RS05320
gene id: 289377:HL41_RS05320
uniprot id: A0A075WUY2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS03280
gene id: 289377:HL41_RS03280
uniprot id: A0A075WZ06
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

289377:HL41 RS00740
gene id: 289377:HL41_RS00740
uniprot id: A0A075WY14
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

289377:HL41 RS02365
gene id: 289377:HL41_RS02365
uniprot id: A0A075WR08
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS08155
gene id: 289377:HL41_RS08155
uniprot id: A0A075X121
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

289377:HL41 RS01620
gene id: 289377:HL41_RS01620
uniprot id: A0A075WYF7
names: Similarity
messages: Belongs to the hemerythrin family.

289377:HL41 RS03495
gene id: 289377:HL41_RS03495
uniprot id: A0A075WSU0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

289377:HL41 RS00205
gene id: 289377:HL41_RS00205
uniprot id: A0A075WPW0
names: Similarity
messages: Belongs to the Ahb/Nir family.

289377:HL41 RS00725
gene id: 289377:HL41_RS00725
uniprot id: A0A075WR94
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

289377:HL41 RS01755
gene id: 289377:HL41_RS01755
uniprot id: A0A075WYG6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS01725
gene id: 289377:HL41_RS01725
uniprot id: A0A075WRN4
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

289377:HL41 RS05185
gene id: 289377:HL41_RS05185
uniprot id: A0A075WZU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

289377:HL41 RS03390
gene id: 289377:HL41_RS03390
uniprot id: A0A075WU45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

289377:HL41 RS03060
gene id: 289377:HL41_RS03060
uniprot id: A0A075WSM2
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS01705
gene id: 289377:HL41_RS01705
uniprot id: A0A075WTE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

289377:HL41 RS00210
gene id: 289377:HL41_RS00210
uniprot id: A0A075WR05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

289377:HL41 RS01300
gene id: 289377:HL41_RS01300
uniprot id: A0A075WT83
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

289377:HL41 RS05695
gene id: 289377:HL41_RS05695
uniprot id: A0A075WTJ5
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

289377:HL41 RS05385
gene id: 289377:HL41_RS05385
uniprot id: A0A075WTA2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS01915
gene id: 289377:HL41_RS01915
uniprot id: A0A075WS48
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

289377:HL41 RS06150
gene id: 289377:HL41_RS06150
uniprot id: A0A075WV96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

289377:HL41 RS08610
gene id: 289377:HL41_RS08610
uniprot id: A0A075WUW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

289377:HL41 RS03675
gene id: 289377:HL41_RS03675
uniprot id: A0A075WZ61
names: Similarity
messages: Belongs to the UxaA family.

289377:HL41 RS02305
gene id: 289377:HL41_RS02305
uniprot id: A0A075WTL7
names: Similarity
messages: Belongs to the AOR/FOR family.

289377:HL41 RS01045
gene id: 289377:HL41_RS01045
uniprot id: A0A075WY67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

289377:HL41 RS02350
gene id: 289377:HL41_RS02350
uniprot id: A0A075WYM5
names: Similarity
messages: Belongs to the SAICAR synthetase family.

289377:HL41 RS03025
gene id: 289377:HL41_RS03025
uniprot id: A0A075WSL6
names: Similarity
messages: Belongs to the MEMO1 family.

289377:HL41 RS03120
gene id: 289377:HL41_RS03120
uniprot id: A0A075WSN3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

289377:HL41 RS01980
gene id: 289377:HL41_RS01980
uniprot id: A0A075WTH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

289377:HL41 RS04375
gene id: 289377:HL41_RS04375
uniprot id: A0A075WTC6
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

289377:HL41 RS03400
gene id: 289377:HL41_RS03400
uniprot id: A0A075WSB8
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS04605
gene id: 289377:HL41_RS04605
uniprot id: A0A075WZN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

289377:HL41 RS04970
gene id: 289377:HL41_RS04970
uniprot id: A0A075WUT4
names: Similarity
messages: Belongs to the HupF/HypC family.

289377:HL41 RS00515
gene id: 289377:HL41_RS00515
uniprot id: A0A075WSQ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

289377:HL41 RS08370
gene id: 289377:HL41_RS08370
uniprot id: A0A075WV00
names: Similarity
messages: Belongs to the HypE family.

289377:HL41 RS06275
gene id: 289377:HL41_RS06275
uniprot id: A0A075WVB1
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS04800
gene id: 289377:HL41_RS04800
uniprot id: A0A075WUR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

289377:HL41 RS04265
gene id: 289377:HL41_RS04265
uniprot id: A0A075WSV9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

289377:HL41 RS08160
gene id: 289377:HL41_RS08160
uniprot id: A0A075WW17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Membrane

289377:HL41 RS02335
gene id: 289377:HL41_RS02335
uniprot id: A0A075WR03
names: Similarity
messages: Belongs to the pyruvate kinase family.

289377:HL41 RS01165
gene id: 289377:HL41_RS01165
uniprot id: A0A075WQG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

289377:HL41 RS09090
gene id: 289377:HL41_RS09090
uniprot id: A0A075WSS7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

289377:HL41 RS03955
gene id: 289377:HL41_RS03955
uniprot id: A0A075WT21
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

289377:HL41 RS03635
gene id: 289377:HL41_RS03635
uniprot id: A0A075WSW4
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

289377:HL41 RS00930
gene id: 289377:HL41_RS00930
uniprot id: A0A075WRM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

289377:HL41 RS00820
gene id: 289377:HL41_RS00820
uniprot id: A0A075WY31
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

289377:HL41 RS05240
gene id: 289377:HL41_RS05240
uniprot id: A0A075WUX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

289377:HL41 RS05150
gene id: 289377:HL41_RS05150
uniprot id: A0A075WT73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

289377:HL41 RS08745
gene id: 289377:HL41_RS08745
uniprot id: A0A075X192
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

289377:HL41 RS01965
gene id: 289377:HL41_RS01965
uniprot id: A0A075WS56
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

289377:HL41 RS02400
gene id: 289377:HL41_RS02400
uniprot id: A0A075WRV0
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS00160
gene id: 289377:HL41_RS00160
uniprot id: A0A075WQZ3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

289377:HL41 RS03840
gene id: 289377:HL41_RS03840
uniprot id: A0A075WZ96
names: Function
names: Subunit
messages: Interacts with sigma-54.
messages: Required for activation of most nif operons, which are directly involved in nitrogen fixation.

289377:HL41 RS04845
gene id: 289377:HL41_RS04845
uniprot id: A0A075WZR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

289377:HL41 RS07155
gene id: 289377:HL41_RS07155
uniprot id: A0A075X0L3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

289377:HL41 RS04290
gene id: 289377:HL41_RS04290
uniprot id: A0A075WSW2
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

289377:HL41 RS08635
gene id: 289377:HL41_RS08635
uniprot id: A0A075WUX1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

289377:HL41 RS05115
gene id: 289377:HL41_RS05115
uniprot id: A0A075WSG9
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

289377:HL41 RS00475
gene id: 289377:HL41_RS00475
uniprot id: A0A075WRE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

289377:HL41 RS09180
gene id: 289377:HL41_RS09180
uniprot id: A0A075WUV9
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS04165
gene id: 289377:HL41_RS04165
uniprot id: A0A075WS01
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

289377:HL41 RS03415
gene id: 289377:HL41_RS03415
uniprot id: A0A075WZ23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

289377:HL41 RS00945
gene id: 289377:HL41_RS00945
uniprot id: A0A075WSX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

289377:HL41 RS02945
gene id: 289377:HL41_RS02945
uniprot id: A0A075WSK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

289377:HL41 RS07625
gene id: 289377:HL41_RS07625
uniprot id: A0A075WVV4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

289377:HL41 RS07670
gene id: 289377:HL41_RS07670
uniprot id: A0A075WTM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

289377:HL41 RS03655
gene id: 289377:HL41_RS03655
uniprot id: A0A075WRM5
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

289377:HL41 RS07900
gene id: 289377:HL41_RS07900
uniprot id: A0A075WUM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

289377:HL41 RS05205
gene id: 289377:HL41_RS05205
uniprot id: A0A075WTM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

289377:HL41 RS08595
gene id: 289377:HL41_RS08595
uniprot id: A0A075X176
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

289377:HL41 RS02950
gene id: 289377:HL41_RS02950
uniprot id: A0A075WYV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

289377:HL41 RS05890
gene id: 289377:HL41_RS05890
uniprot id: A0A075WV52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

289377:HL41 RS02845
gene id: 289377:HL41_RS02845
uniprot id: A0A075WTW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

289377:HL41 RS00070
gene id: 289377:HL41_RS00070
uniprot id: A0A075WPT6
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

289377:HL41 RS00080
gene id: 289377:HL41_RS00080
uniprot id: A0A075WR76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

289377:HL41 RS07765
gene id: 289377:HL41_RS07765
uniprot id: A0A075X0X1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS08890
gene id: 289377:HL41_RS08890
uniprot id: A0A075WY54
names: Similarity
messages: Belongs to the bacterial flagellin family.

289377:HL41 RS07525
gene id: 289377:HL41_RS07525
uniprot id: A0A075X0T5
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

289377:HL41 RS04280
gene id: 289377:HL41_RS04280
uniprot id: A0A075WUJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

289377:HL41 RS06300
gene id: 289377:HL41_RS06300
uniprot id: A0A075WVB3
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

289377:HL41 RS03145
gene id: 289377:HL41_RS03145
uniprot id: A0A075WSN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

289377:HL41 RS01085
gene id: 289377:HL41_RS01085
uniprot id: A0A075WRF4
names: Similarity
messages: Belongs to the archease family.

289377:HL41 RS01010
gene id: 289377:HL41_RS01010
uniprot id: A0A075WRP0
names: Similarity
messages: Belongs to the threonine synthase family.

289377:HL41 RS05105
gene id: 289377:HL41_RS05105
uniprot id: A0A075WZT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

289377:HL41 RS00145
gene id: 289377:HL41_RS00145
uniprot id: A0A075WXS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

289377:HL41 RS04805
gene id: 289377:HL41_RS04805
uniprot id: A0A075WSC3
names: Similarity
messages: Belongs to the Ahb/Nir family.

289377:HL41 RS05710
gene id: 289377:HL41_RS05710
uniprot id: A0A075WTW0
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

289377:HL41 RS06665
gene id: 289377:HL41_RS06665
uniprot id: A0A075WYS4
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS00540
gene id: 289377:HL41_RS00540
uniprot id: A0A075WSQ6
names: Subcellular Location Annotation
messages: Cytoplasm

289377:HL41 RS05905
gene id: 289377:HL41_RS05905
uniprot id: A0A075WTN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

289377:HL41 RS04635
gene id: 289377:HL41_RS04635
uniprot id: A0A075WT16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

289377:HL41 RS00235
gene id: 289377:HL41_RS00235
uniprot id: A0A075WSK3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

289377:HL41 RS00350
gene id: 289377:HL41_RS00350
uniprot id: A0A075WPY6
names: Similarity
messages: Belongs to the peptidase C56 family.

289377:HL41 RS01785
gene id: 289377:HL41_RS01785
uniprot id: A0A075WS31
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

289377:HL41 RS04950
gene id: 289377:HL41_RS04950
uniprot id: A0A075WT49
names: Similarity
messages: Belongs to the AOR/FOR family.

289377:HL41 RS08260
gene id: 289377:HL41_RS08260
uniprot id: A0A075X135
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

289377:HL41 RS02260
gene id: 289377:HL41_RS02260
uniprot id: A0A075WQY7
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

289377:HL41 RS03455
gene id: 289377:HL41_RS03455
uniprot id: A0A075WRI7
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

289377:HL41 RS04870
gene id: 289377:HL41_RS04870
uniprot id: A0A075WTI1
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

289377:HL41 RS01510
gene id: 289377:HL41_RS01510
uniprot id: A0A075WYE5
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS01115
gene id: 289377:HL41_RS01115
uniprot id: A0A075WRF7
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

289377:HL41 RS01815
gene id: 289377:HL41_RS01815
uniprot id: A0A075WS36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS01710
gene id: 289377:HL41_RS01710
uniprot id: A0A075WQR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

289377:HL41 RS07415
gene id: 289377:HL41_RS07415
uniprot id: A0A075X0S3
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

289377:HL41 RS01835
gene id: 289377:HL41_RS01835
uniprot id: A0A075WQS7
names: Similarity
messages: Belongs to the GSP E family.

289377:HL41 RS02055
gene id: 289377:HL41_RS02055
uniprot id: A0A075WS64
names: Similarity
messages: Belongs to the glutamine synthetase family.

289377:HL41 RS06400
gene id: 289377:HL41_RS06400
uniprot id: A0A075WTX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

289377:HL41 RS07825
gene id: 289377:HL41_RS07825
uniprot id: A0A075WUT3
names: Caution
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

289377:HL41 RS05165
gene id: 289377:HL41_RS05165
uniprot id: A0A075WUV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

289377:HL41 RS05140
gene id: 289377:HL41_RS05140
uniprot id: A0A075WUV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

289377:HL41 RS00815
gene id: 289377:HL41_RS00815
uniprot id: A0A075WRJ4
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS05790
gene id: 289377:HL41_RS05790
uniprot id: A0A075X019
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

289377:HL41 RS04665
gene id: 289377:HL41_RS04665
uniprot id: A0A075WTF9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

289377:HL41 RS04900
gene id: 289377:HL41_RS04900
uniprot id: A0A075WSD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

289377:HL41 RS08790
gene id: 289377:HL41_RS08790
uniprot id: A0A075WU61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

289377:HL41 RS01950
gene id: 289377:HL41_RS01950
uniprot id: A0A075WTG9
names: Similarity
messages: Belongs to the peptidase S66 family.

289377:HL41 RS00875
gene id: 289377:HL41_RS00875
uniprot id: A0A075WRB9
names: Similarity
messages: Belongs to the RemA family.

289377:HL41 RS00480
gene id: 289377:HL41_RS00480
uniprot id: A0A075WXX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

289377:HL41 RS07160
gene id: 289377:HL41_RS07160
uniprot id: A0A075WVP0
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

289377:HL41 RS03590
gene id: 289377:HL41_RS03590
uniprot id: A0A075WRL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

289377:HL41 RS08465
gene id: 289377:HL41_RS08465
uniprot id: A0A075WV11
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

289377:HL41 RS08675
gene id: 289377:HL41_RS08675
uniprot id: A0A075WW98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

289377:HL41 RS03825
gene id: 289377:HL41_RS03825
uniprot id: A0A075WRQ6
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS00305
gene id: 289377:HL41_RS00305
uniprot id: A0A075WR22
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

289377:HL41 RS03975
gene id: 289377:HL41_RS03975
uniprot id: A0A075WSN0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

289377:HL41 RS05755
gene id: 289377:HL41_RS05755
uniprot id: A0A075WV40
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

289377:HL41 RS06170
gene id: 289377:HL41_RS06170
uniprot id: A0A075X075
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

289377:HL41 RS03325
gene id: 289377:HL41_RS03325
uniprot id: A0A075WRG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

289377:HL41 RS01935
gene id: 289377:HL41_RS01935
uniprot id: A0A075WRQ2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

289377:HL41 RS01250
gene id: 289377:HL41_RS01250
uniprot id: A0A075WT76
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

289377:HL41 RS06895
gene id: 289377:HL41_RS06895
uniprot id: A0A075X0G8
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

289377:HL41 RS05110
gene id: 289377:HL41_RS05110
uniprot id: A0A075WUV0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

289377:HL41 RS03650
gene id: 289377:HL41_RS03650
uniprot id: A0A075WU91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

289377:HL41 RS00570
gene id: 289377:HL41_RS00570
uniprot id: A0A075WSR1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

289377:HL41 RS00180
gene id: 289377:HL41_RS00180
uniprot id: A0A075WPV4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS05670
gene id: 289377:HL41_RS05670
uniprot id: A0A075X007
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

289377:HL41 RS05325
gene id: 289377:HL41_RS05325
uniprot id: A0A075WSL0
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

289377:HL41 RS06080
gene id: 289377:HL41_RS06080
uniprot id: A0A075WU16
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

289377:HL41 RS01305
gene id: 289377:HL41_RS01305
uniprot id: A0A075WQJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

289377:HL41 RS01665
gene id: 289377:HL41_RS01665
uniprot id: A0A075WRM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

289377:HL41 RS06160
gene id: 289377:HL41_RS06160
uniprot id: A0A075WTT3
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

289377:HL41 RS01680
gene id: 289377:HL41_RS01680
uniprot id: A0A075WTE2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

289377:HL41 RS05780
gene id: 289377:HL41_RS05780
uniprot id: A0A075WTK8
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

289377:HL41 RS06405
gene id: 289377:HL41_RS06405
uniprot id: A0A075WU58
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

289377:HL41 RS03990
gene id: 289377:HL41_RS03990
uniprot id: A0A075WUD7
names: Similarity
messages: Belongs to the CinA family.

289377:HL41 RS05085
gene id: 289377:HL41_RS05085
uniprot id: A0A075WSG4
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS02910
gene id: 289377:HL41_RS02910
uniprot id: A0A075WS29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

289377:HL41 RS00765
gene id: 289377:HL41_RS00765
uniprot id: A0A075WRI3
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS06545
gene id: 289377:HL41_RS06545
uniprot id: A0A075X0B9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

289377:HL41 RS01545
gene id: 289377:HL41_RS01545
uniprot id: A0A075WTC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

289377:HL41 RS08455
gene id: 289377:HL41_RS08455
uniprot id: A0A075WTY6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

289377:HL41 RS01370
gene id: 289377:HL41_RS01370
uniprot id: A0A075WQK1
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

289377:HL41 RS02435
gene id: 289377:HL41_RS02435
uniprot id: A0A075WYN7
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

289377:HL41 RS01575
gene id: 289377:HL41_RS01575
uniprot id: A0A075WQN9
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS04205
gene id: 289377:HL41_RS04205
uniprot id: A0A075WSV2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

289377:HL41 RS04155
gene id: 289377:HL41_RS04155
uniprot id: A0A075WZF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

289377:HL41 RS04470
gene id: 289377:HL41_RS04470
uniprot id: A0A075WUL6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

289377:HL41 RS07310
gene id: 289377:HL41_RS07310
uniprot id: A0A075WUE9
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

289377:HL41 RS01805
gene id: 289377:HL41_RS01805
uniprot id: A0A075WQS4
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

289377:HL41 RS04490
gene id: 289377:HL41_RS04490
uniprot id: A0A075WS70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

289377:HL41 RS05285
gene id: 289377:HL41_RS05285
uniprot id: A0A075WZV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

289377:HL41 RS08440
gene id: 289377:HL41_RS08440
uniprot id: A0A075X157
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

289377:HL41 RS08325
gene id: 289377:HL41_RS08325
uniprot id: A0A075WTW5
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS04915
gene id: 289377:HL41_RS04915
uniprot id: A0A075WZR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

289377:HL41 RS01780
gene id: 289377:HL41_RS01780
uniprot id: A0A075WRN7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

289377:HL41 RS07960
gene id: 289377:HL41_RS07960
uniprot id: A0A075WUN2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

289377:HL41 RS02165
gene id: 289377:HL41_RS02165
uniprot id: A0A075WYK4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

289377:HL41 RS00935
gene id: 289377:HL41_RS00935
uniprot id: A0A075WY49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgA family.
messages: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
messages: Periplasm

289377:HL41 RS07675
gene id: 289377:HL41_RS07675
uniprot id: A0A075WUJ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

289377:HL41 RS06365
gene id: 289377:HL41_RS06365
uniprot id: A0A075WTW9
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

289377:HL41 RS03385
gene id: 289377:HL41_RS03385
uniprot id: A0A075WZ19
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

289377:HL41 RS04660
gene id: 289377:HL41_RS04660
uniprot id: A0A075WT20
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

289377:HL41 RS02860
gene id: 289377:HL41_RS02860
uniprot id: A0A075WSI7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

289377:HL41 RS08150
gene id: 289377:HL41_RS08150
uniprot id: A0A075WUW9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

289377:HL41 RS02680
gene id: 289377:HL41_RS02680
uniprot id: A0A075WRY8
names: Similarity
messages: Belongs to the sigma-54 factor family.

289377:HL41 RS07965
gene id: 289377:HL41_RS07965
uniprot id: A0A075WUV1
names: Similarity
messages: Belongs to the PstS family.

289377:HL41 RS04145
gene id: 289377:HL41_RS04145
uniprot id: A0A075WSR6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

289377:HL41 RS00660
gene id: 289377:HL41_RS00660
uniprot id: A0A075WY03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

289377:HL41 RS04320
gene id: 289377:HL41_RS04320
uniprot id: A0A075WSW5
names: Similarity
messages: Belongs to the peptidase S41A family.

289377:HL41 RS06260
gene id: 289377:HL41_RS06260
uniprot id: A0A075WTV0
names: Similarity
messages: Belongs to the TlyA family.

289377:HL41 RS04500
gene id: 289377:HL41_RS04500
uniprot id: A0A075WTE0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

289377:HL41 RS07395
gene id: 289377:HL41_RS07395
uniprot id: A0A075WVT8
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

289377:HL41 RS02630
gene id: 289377:HL41_RS02630
uniprot id: A0A075WYR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

289377:HL41 RS05260
gene id: 289377:HL41_RS05260
uniprot id: A0A075WZV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

289377:HL41 RS07355
gene id: 289377:HL41_RS07355
uniprot id: A0A075WUL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

289377:HL41 RS01125
gene id: 289377:HL41_RS01125
uniprot id: A0A075WY78
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

289377:HL41 RS07930
gene id: 289377:HL41_RS07930
uniprot id: A0A075WUM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

289377:HL41 RS03370
gene id: 289377:HL41_RS03370
uniprot id: A0A075WRH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

289377:HL41 RS07835
gene id: 289377:HL41_RS07835
uniprot id: A0A075X0X9
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

289377:HL41 RS08435
gene id: 289377:HL41_RS08435
uniprot id: A0A075WYS4
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS00905
gene id: 289377:HL41_RS00905
uniprot id: A0A075WRL3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

289377:HL41 RS05600
gene id: 289377:HL41_RS05600
uniprot id: A0A075WZZ9
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS02995
gene id: 289377:HL41_RS02995
uniprot id: A0A075WSL2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS00585
gene id: 289377:HL41_RS00585
uniprot id: A0A075WRF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

289377:HL41 RS03740
gene id: 289377:HL41_RS03740
uniprot id: A0A075WSI2
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS05300
gene id: 289377:HL41_RS05300
uniprot id: A0A075WTA5
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS00435
gene id: 289377:HL41_RS00435
uniprot id: A0A075WSN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

289377:HL41 RS05000
gene id: 289377:HL41_RS05000
uniprot id: A0A075WSF3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

289377:HL41 RS04405
gene id: 289377:HL41_RS04405
uniprot id: A0A075WTD1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

289377:HL41 RS06890
gene id: 289377:HL41_RS06890
uniprot id: A0A075WUB7
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

289377:HL41 RS01830
gene id: 289377:HL41_RS01830
uniprot id: A0A075WTF7
names: Similarity
messages: Belongs to the GSP E family.

289377:HL41 RS08660
gene id: 289377:HL41_RS08660
uniprot id: A0A075WUX6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

289377:HL41 RS03545
gene id: 289377:HL41_RS03545
uniprot id: A0A075WSU8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS05280
gene id: 289377:HL41_RS05280
uniprot id: A0A075WTP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

289377:HL41 RS05425
gene id: 289377:HL41_RS05425
uniprot id: A0A075WTC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

289377:HL41 RS02180
gene id: 289377:HL41_RS02180
uniprot id: A0A075WQX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

289377:HL41 RS06200
gene id: 289377:HL41_RS06200
uniprot id: A0A075WU31
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

289377:HL41 RS03620
gene id: 289377:HL41_RS03620
uniprot id: A0A075WRM1
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

289377:HL41 RS01560
gene id: 289377:HL41_RS01560
uniprot id: A0A075WS07
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

289377:HL41 RS02575
gene id: 289377:HL41_RS02575
uniprot id: A0A075WTR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

289377:HL41 RS08205
gene id: 289377:HL41_RS08205
uniprot id: A0A075X128
names: Cofactor
messages: Binds 4 [4Fe-4S] clusters per subunit.

289377:HL41 RS05265
gene id: 289377:HL41_RS05265
uniprot id: A0A075WUX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

289377:HL41 RS03080
gene id: 289377:HL41_RS03080
uniprot id: A0A075WS63
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

289377:HL41 RS05640
gene id: 289377:HL41_RS05640
uniprot id: A0A075WSQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

289377:HL41 RS00925
gene id: 289377:HL41_RS00925
uniprot id: A0A075WRC7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

289377:HL41 RS07385
gene id: 289377:HL41_RS07385
uniprot id: A0A075WUL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

289377:HL41 RS00560
gene id: 289377:HL41_RS00560
uniprot id: A0A075WRF3
names: Similarity
messages: Belongs to the Fur family.

289377:HL41 RS07515
gene id: 289377:HL41_RS07515
uniprot id: A0A075WUI1
names: Similarity
messages: Belongs to the Fur family.

289377:HL41 RS03805
gene id: 289377:HL41_RS03805
uniprot id: A0A075WZ90
names: Similarity
messages: Belongs to the CsgA/CsgB family.

289377:HL41 RS01075
gene id: 289377:HL41_RS01075
uniprot id: A0A075WT05
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

289377:HL41 RS01060
gene id: 289377:HL41_RS01060
uniprot id: A0A075WRF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

289377:HL41 RS06280
gene id: 289377:HL41_RS06280
uniprot id: A0A075WSZ0
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS05225
gene id: 289377:HL41_RS05225
uniprot id: A0A075WT88
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

289377:HL41 RS03960
gene id: 289377:HL41_RS03960
uniprot id: A0A075WZB8
names: Similarity
messages: Belongs to the ParB family.

289377:HL41 RS07220
gene id: 289377:HL41_RS07220
uniprot id: A0A075WVP9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

289377:HL41 RS07210
gene id: 289377:HL41_RS07210
uniprot id: A0A075WUG3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS02585
gene id: 289377:HL41_RS02585
uniprot id: A0A075WR50
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

289377:HL41 RS00520
gene id: 289377:HL41_RS00520
uniprot id: A0A075WQ20
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

289377:HL41 RS06380
gene id: 289377:HL41_RS06380
uniprot id: A0A075X097
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS07800
gene id: 289377:HL41_RS07800
uniprot id: A0A075X0X5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

289377:HL41 RS07080
gene id: 289377:HL41_RS07080
uniprot id: A0A075WU80
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS03915
gene id: 289377:HL41_RS03915
uniprot id: A0A075WRS1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

289377:HL41 RS05995
gene id: 289377:HL41_RS05995
uniprot id: A0A075X049
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

289377:HL41 RS02550
gene id: 289377:HL41_RS02550
uniprot id: A0A075WRX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

289377:HL41 RS04780
gene id: 289377:HL41_RS04780
uniprot id: A0A075WSB6
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

289377:HL41 RS05440
gene id: 289377:HL41_RS05440
uniprot id: A0A075WUZ8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

289377:HL41 RS08605
gene id: 289377:HL41_RS08605
uniprot id: A0A075WU33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

289377:HL41 RS00245
gene id: 289377:HL41_RS00245
uniprot id: A0A075WPW5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

289377:HL41 RS01230
gene id: 289377:HL41_RS01230
uniprot id: A0A075WRW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

289377:HL41 RS06395
gene id: 289377:HL41_RS06395
uniprot id: A0A075WT02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

289377:HL41 RS07890
gene id: 289377:HL41_RS07890
uniprot id: A0A075WVY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

289377:HL41 RS04965
gene id: 289377:HL41_RS04965
uniprot id: A0A075WZR8
names: Similarity
messages: Belongs to the HypD family.

289377:HL41 RS04315
gene id: 289377:HL41_RS04315
uniprot id: A0A075WS42
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS03485
gene id: 289377:HL41_RS03485
uniprot id: A0A075WRJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

289377:HL41 RS04525
gene id: 289377:HL41_RS04525
uniprot id: A0A075WTE3
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

289377:HL41 RS05930
gene id: 289377:HL41_RS05930
uniprot id: A0A075WTN7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

289377:HL41 RS05635
gene id: 289377:HL41_RS05635
uniprot id: A0A075WV29
names: Similarity
messages: Belongs to the RuvC family.

289377:HL41 RS03790
gene id: 289377:HL41_RS03790
uniprot id: A0A075WRQ1
names: Function
messages: May be involved in the biogenesis of curli organelles.

289377:HL41 RS02850
gene id: 289377:HL41_RS02850
uniprot id: A0A075WR92
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS08195
gene id: 289377:HL41_RS08195
uniprot id: A0A075WUR2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

289377:HL41 RS04555
gene id: 289377:HL41_RS04555
uniprot id: A0A075WZM8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

289377:HL41 RS04085
gene id: 289377:HL41_RS04085
uniprot id: A0A075WSQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

289377:HL41 RS04960
gene id: 289377:HL41_RS04960
uniprot id: A0A075WTI7
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

289377:HL41 RS07940
gene id: 289377:HL41_RS07940
uniprot id: A0A075X0Z5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

289377:HL41 RS07615
gene id: 289377:HL41_RS07615
uniprot id: A0A075WUQ1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS06245
gene id: 289377:HL41_RS06245
uniprot id: A0A075X083
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

289377:HL41 RS05870
gene id: 289377:HL41_RS05870
uniprot id: A0A075WTY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

289377:HL41 RS00170
gene id: 289377:HL41_RS00170
uniprot id: A0A075WXS7
names: Similarity
messages: Belongs to the LacAB/RpiB family.

289377:HL41 RS03030
gene id: 289377:HL41_RS03030
uniprot id: A0A075WYW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

289377:HL41 RS08340
gene id: 289377:HL41_RS08340
uniprot id: A0A075WUT2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

289377:HL41 RS06335
gene id: 289377:HL41_RS06335
uniprot id: A0A075WVB6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

289377:HL41 RS04125
gene id: 289377:HL41_RS04125
uniprot id: A0A075WZF2
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

289377:HL41 RS05725
gene id: 289377:HL41_RS05725
uniprot id: A0A075WSR7
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.

289377:HL41 RS05900
gene id: 289377:HL41_RS05900
uniprot id: A0A075WST5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

289377:HL41 RS00840
gene id: 289377:HL41_RS00840
uniprot id: A0A075WRK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

289377:HL41 RS04840
gene id: 289377:HL41_RS04840
uniprot id: A0A075WTH7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

289377:HL41 RS05840
gene id: 289377:HL41_RS05840
uniprot id: A0A075WTL8
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

289377:HL41 RS04795
gene id: 289377:HL41_RS04795
uniprot id: A0A075WZQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

289377:HL41 RS06450
gene id: 289377:HL41_RS06450
uniprot id: A0A075WT10
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

289377:HL41 RS06500
gene id: 289377:HL41_RS06500
uniprot id: A0A075X0B4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS01260
gene id: 289377:HL41_RS01260
uniprot id: A0A075WRI4
names: Similarity
messages: Belongs to the GARS family.

289377:HL41 RS01315
gene id: 289377:HL41_RS01315
uniprot id: A0A075WRX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

289377:HL41 RS05855
gene id: 289377:HL41_RS05855
uniprot id: A0A075WV49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

289377:HL41 RS08310
gene id: 289377:HL41_RS08310
uniprot id: A0A075WUZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

289377:HL41 RS04300
gene id: 289377:HL41_RS04300
uniprot id: A0A075WTB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

289377:HL41 RS02530
gene id: 289377:HL41_RS02530
uniprot id: A0A075WSD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliR/MopE/SpaR family.
messages: Membrane

289377:HL41 RS01535
gene id: 289377:HL41_RS01535
uniprot id: A0A075WS03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

289377:HL41 RS05350
gene id: 289377:HL41_RS05350
uniprot id: A0A075WTQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm

289377:HL41 RS05560
gene id: 289377:HL41_RS05560
uniprot id: A0A075WTH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

289377:HL41 RS08475
gene id: 289377:HL41_RS08475
uniprot id: A0A075WW67
names: Similarity
messages: Belongs to the universal stress protein A family.

289377:HL41 RS08375
gene id: 289377:HL41_RS08375
uniprot id: A0A075X150
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

289377:HL41 RS01850
gene id: 289377:HL41_RS01850
uniprot id: A0A075WYH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

289377:HL41 RS06945
gene id: 289377:HL41_RS06945
uniprot id: A0A075WU52
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

289377:HL41 RS04425
gene id: 289377:HL41_RS04425
uniprot id: A0A075WS59
names: Similarity
messages: Belongs to the YggT family.

289377:HL41 RS08880
gene id: 289377:HL41_RS08880
uniprot id: A0A075WY08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

289377:HL41 RS03010
gene id: 289377:HL41_RS03010
uniprot id: A0A075WTZ0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

289377:HL41 RS06290
gene id: 289377:HL41_RS06290
uniprot id: A0A075WU42
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS01925
gene id: 289377:HL41_RS01925
uniprot id: A0A075WTG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

289377:HL41 RS06870
gene id: 289377:HL41_RS06870
uniprot id: A0A075WT61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

289377:HL41 RS05815
gene id: 289377:HL41_RS05815
uniprot id: A0A075WTX5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

289377:HL41 RS08180
gene id: 289377:HL41_RS08180
uniprot id: A0A075X124
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

289377:HL41 RS08445
gene id: 289377:HL41_RS08445
uniprot id: A0A075WW62
names: Similarity
messages: Belongs to the Nudix hydrolase family.

289377:HL41 RS03075
gene id: 289377:HL41_RS03075
uniprot id: A0A075WRD0
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

289377:HL41 RS08360
gene id: 289377:HL41_RS08360
uniprot id: A0A075WTX1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

289377:HL41 RS03065
gene id: 289377:HL41_RS03065
uniprot id: A0A075WYX1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

289377:HL41 RS02605
gene id: 289377:HL41_RS02605
uniprot id: A0A075WTS4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS05195
gene id: 289377:HL41_RS05195
uniprot id: A0A075WSI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

289377:HL41 RS06310
gene id: 289377:HL41_RS06310
uniprot id: A0A075WYS4
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS06140
gene id: 289377:HL41_RS06140
uniprot id: A0A075WYS4
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS06455
gene id: 289377:HL41_RS06455
uniprot id: A0A075WTY5
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

289377:HL41 RS08700
gene id: 289377:HL41_RS08700
uniprot id: A0A075WV39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

289377:HL41 RS02045
gene id: 289377:HL41_RS02045
uniprot id: A0A075WQV6
names: Similarity
messages: Belongs to the glutamate synthase family.

289377:HL41 RS01520
gene id: 289377:HL41_RS01520
uniprot id: A0A075WTB8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

289377:HL41 RS00630
gene id: 289377:HL41_RS00630
uniprot id: A0A075WXZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

289377:HL41 RS01205
gene id: 289377:HL41_RS01205
uniprot id: A0A075WRW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

289377:HL41 RS04460
gene id: 289377:HL41_RS04460
uniprot id: A0A075WTD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

289377:HL41 RS07435
gene id: 289377:HL41_RS07435
uniprot id: A0A075WUN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

289377:HL41 RS05245
gene id: 289377:HL41_RS05245
uniprot id: A0A075WSJ5
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

289377:HL41 RS04450
gene id: 289377:HL41_RS04450
uniprot id: A0A075WS65
names: Similarity
messages: Belongs to the rubredoxin family.

289377:HL41 RS06535
gene id: 289377:HL41_RS06535
uniprot id: A0A075WTZ6
names: Similarity
messages: Belongs to the class-I fumarase family.

289377:HL41 RS00365
gene id: 289377:HL41_RS00365
uniprot id: A0A075WRB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

289377:HL41 RS00045
gene id: 289377:HL41_RS00045
uniprot id: A0A075WXR2
names: Similarity
messages: Belongs to the UPF0111 family.

289377:HL41 RS07980
gene id: 289377:HL41_RS07980
uniprot id: A0A075WTR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

289377:HL41 RS02515
gene id: 289377:HL41_RS02515
uniprot id: A0A075WTQ6
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

289377:HL41 RS02645
gene id: 289377:HL41_RS02645
uniprot id: A0A075WRY3
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

289377:HL41 RS00795
gene id: 289377:HL41_RS00795
uniprot id: A0A075WY25
names: Similarity
messages: Belongs to the peptidase M18 family.

289377:HL41 RS08680
gene id: 289377:HL41_RS08680
uniprot id: A0A075WU48
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

289377:HL41 RS01225
gene id: 289377:HL41_RS01225
uniprot id: A0A075WRI1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

289377:HL41 RS07280
gene id: 289377:HL41_RS07280
uniprot id: A0A075WYS4
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS02070
gene id: 289377:HL41_RS02070
uniprot id: A0A075WTI2
names: Similarity
messages: Belongs to the P(II) protein family.

289377:HL41 RS03215
gene id: 289377:HL41_RS03215
uniprot id: A0A075WYS4
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS01985
gene id: 289377:HL41_RS01985
uniprot id: A0A075WQV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

289377:HL41 RS04755
gene id: 289377:HL41_RS04755
uniprot id: A0A075WSB2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

289377:HL41 RS04110
gene id: 289377:HL41_RS04110
uniprot id: A0A075WRW5
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

289377:HL41 RS00165
gene id: 289377:HL41_RS00165
uniprot id: A0A075WR88
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

289377:HL41 RS01080
gene id: 289377:HL41_RS01080
uniprot id: A0A075WQC5
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS05100
gene id: 289377:HL41_RS05100
uniprot id: A0A075WTK9
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

289377:HL41 RS08665
gene id: 289377:HL41_RS08665
uniprot id: A0A075WV36
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

289377:HL41 RS00175
gene id: 289377:HL41_RS00175
uniprot id: A0A075WSJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

289377:HL41 RS02265
gene id: 289377:HL41_RS02265
uniprot id: A0A075WRT1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS02755
gene id: 289377:HL41_RS02755
uniprot id: A0A075WTU9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

289377:HL41 RS01015
gene id: 289377:HL41_RS01015
uniprot id: A0A075WY65
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

289377:HL41 RS04365
gene id: 289377:HL41_RS04365
uniprot id: A0A075WS50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

289377:HL41 RS00470
gene id: 289377:HL41_RS00470
uniprot id: A0A075WR53
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

289377:HL41 RS01930
gene id: 289377:HL41_RS01930
uniprot id: A0A075WQU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

289377:HL41 RS01675
gene id: 289377:HL41_RS01675
uniprot id: A0A075WYG2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

289377:HL41 RS01415
gene id: 289377:HL41_RS01415
uniprot id: A0A075WRY9
names: Similarity
messages: Belongs to the UPF0102 family.

289377:HL41 RS04540
gene id: 289377:HL41_RS04540
uniprot id: A0A075WS80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

289377:HL41 RS03460
gene id: 289377:HL41_RS03460
uniprot id: A0A075WSD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein S18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

289377:HL41 RS00190
gene id: 289377:HL41_RS00190
uniprot id: A0A075WR93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

289377:HL41 RS00105
gene id: 289377:HL41_RS00105
uniprot id: A0A075WR80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

289377:HL41 RS01885
gene id: 289377:HL41_RS01885
uniprot id: A0A075WS43
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS05950
gene id: 289377:HL41_RS05950
uniprot id: A0A075WSU1
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

289377:HL41 RS02520
gene id: 289377:HL41_RS02520
uniprot id: A0A075WR40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

289377:HL41 RS01530
gene id: 289377:HL41_RS01530
uniprot id: A0A075WRL1
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

289377:HL41 RS05335
gene id: 289377:HL41_RS05335
uniprot id: A0A075WTQ3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS00120
gene id: 289377:HL41_RS00120
uniprot id: A0A075WSI6
names: Similarity
messages: Belongs to the class-I fumarase family.

289377:HL41 RS01035
gene id: 289377:HL41_RS01035
uniprot id: A0A075WRE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

289377:HL41 RS01490
gene id: 289377:HL41_RS01490
uniprot id: A0A075WQM3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

289377:HL41 RS02830
gene id: 289377:HL41_RS02830
uniprot id: A0A075WS13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

289377:HL41 RS03730
gene id: 289377:HL41_RS03730
uniprot id: A0A075WUA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

289377:HL41 RS00880
gene id: 289377:HL41_RS00880
uniprot id: A0A075WRK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

289377:HL41 RS08775
gene id: 289377:HL41_RS08775
uniprot id: A0A075WV46
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

289377:HL41 RS05420
gene id: 289377:HL41_RS05420
uniprot id: A0A075WSM3
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS02540
gene id: 289377:HL41_RS02540
uniprot id: A0A075WTR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

289377:HL41 RS04910
gene id: 289377:HL41_RS04910
uniprot id: A0A075WTI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

289377:HL41 RS04495
gene id: 289377:HL41_RS04495
uniprot id: A0A075WSZ1
names: Similarity
messages: Belongs to the creatininase superfamily.

289377:HL41 RS01700
gene id: 289377:HL41_RS01700
uniprot id: A0A075WYG4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

289377:HL41 RS04640
gene id: 289377:HL41_RS04640
uniprot id: A0A075WTF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

289377:HL41 RS08300
gene id: 289377:HL41_RS08300
uniprot id: A0A075WUS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

289377:HL41 RS01690
gene id: 289377:HL41_RS01690
uniprot id: A0A075WRN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

289377:HL41 RS00215
gene id: 289377:HL41_RS00215
uniprot id: A0A075WR98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

289377:HL41 RS07375
gene id: 289377:HL41_RS07375
uniprot id: A0A075WTI8
names: Similarity
messages: Belongs to the Skp family.

289377:HL41 RS03565
gene id: 289377:HL41_RS03565
uniprot id: A0A075WRL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

289377:HL41 RS02425
gene id: 289377:HL41_RS02425
uniprot id: A0A075WRV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

289377:HL41 RS03440
gene id: 289377:HL41_RS03440
uniprot id: A0A075WZ26
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

289377:HL41 RS00590
gene id: 289377:HL41_RS00590
uniprot id: A0A075WXZ5
names: Similarity
messages: Belongs to the universal stress protein A family.

289377:HL41 RS04995
gene id: 289377:HL41_RS04995
uniprot id: A0A075WUT8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

289377:HL41 RS04090
gene id: 289377:HL41_RS04090
uniprot id: A0A075WT48
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

289377:HL41 RS03950
gene id: 289377:HL41_RS03950
uniprot id: A0A075WSM4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

289377:HL41 RS03900
gene id: 289377:HL41_RS03900
uniprot id: A0A075WT11
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

289377:HL41 RS03135
gene id: 289377:HL41_RS03135
uniprot id: A0A075WRE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

289377:HL41 RS06435
gene id: 289377:HL41_RS06435
uniprot id: A0A075WTA2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS04075
gene id: 289377:HL41_RS04075
uniprot id: A0A075WRV9
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

289377:HL41 RS07110
gene id: 289377:HL41_RS07110
uniprot id: A0A075WUE7
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

289377:HL41 RS05935
gene id: 289377:HL41_RS05935
uniprot id: A0A075WTZ5
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

289377:HL41 RS07805
gene id: 289377:HL41_RS07805
uniprot id: A0A075WVX5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

289377:HL41 RS05125
gene id: 289377:HL41_RS05125
uniprot id: A0A075WT71
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

289377:HL41 RS04035
gene id: 289377:HL41_RS04035
uniprot id: A0A075WZD6
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

289377:HL41 RS08720
gene id: 289377:HL41_RS08720
uniprot id: A0A075WU53
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

289377:HL41 RS06910
gene id: 289377:HL41_RS06910
uniprot id: A0A075WT65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

289377:HL41 RS01500
gene id: 289377:HL41_RS01500
uniprot id: A0A075WRZ9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS02835
gene id: 289377:HL41_RS02835
uniprot id: A0A075WSI3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

289377:HL41 RS00040
gene id: 289377:HL41_RS00040
uniprot id: A0A075WR72
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS07745
gene id: 289377:HL41_RS07745
uniprot id: A0A075WYS4
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS04095
gene id: 289377:HL41_RS04095
uniprot id: A0A075WZE7
names: Similarity
messages: Belongs to the GSP E family.

289377:HL41 RS07005
gene id: 289377:HL41_RS07005
uniprot id: A0A075WU64
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

289377:HL41 RS05175
gene id: 289377:HL41_RS05175
uniprot id: A0A075WT78
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

289377:HL41 RS05430
gene id: 289377:HL41_RS05430
uniprot id: A0A075WTR7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS02390
gene id: 289377:HL41_RS02390
uniprot id: A0A075WTN0
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

289377:HL41 RS08535
gene id: 289377:HL41_RS08535
uniprot id: A0A075WUW0
names: Similarity
messages: Belongs to the HdrA family.

289377:HL41 RS05275
gene id: 289377:HL41_RS05275
uniprot id: A0A075WW80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

289377:HL41 RS01240
gene id: 289377:HL41_RS01240
uniprot id: A0A075WYB7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

289377:HL41 RS05565
gene id: 289377:HL41_RS05565
uniprot id: A0A075WTU2
names: Similarity
messages: Belongs to the UPF0047 family.

289377:HL41 RS03835
gene id: 289377:HL41_RS03835
uniprot id: A0A075WT01
names: Similarity
messages: Belongs to the glutamate synthase family.

289377:HL41 RS00715
gene id: 289377:HL41_RS00715
uniprot id: A0A075WST3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

289377:HL41 RS00155
gene id: 289377:HL41_RS00155
uniprot id: A0A075WPU9
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS08620
gene id: 289377:HL41_RS08620
uniprot id: A0A075X180
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

289377:HL41 RS05415
gene id: 289377:HL41_RS05415
uniprot id: A0A075WUZ4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

289377:HL41 RS08120
gene id: 289377:HL41_RS08120
uniprot id: A0A075X117
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

289377:HL41 RS06195
gene id: 289377:HL41_RS06195
uniprot id: A0A075WTT9
names: Similarity
messages: Belongs to the RecJ family.

289377:HL41 RS00960
gene id: 289377:HL41_RS00960
uniprot id: A0A075WRM6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

289377:HL41 RS06100
gene id: 289377:HL41_RS06100
uniprot id: A0A075WSW3
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS03435
gene id: 289377:HL41_RS03435
uniprot id: A0A075WST2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

289377:HL41 RS05545
gene id: 289377:HL41_RS05545
uniprot id: A0A075WZZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

289377:HL41 RS00705
gene id: 289377:HL41_RS00705
uniprot id: A0A075WRH4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

289377:HL41 RS04045
gene id: 289377:HL41_RS04045
uniprot id: A0A075WRV2
names: Subunit
messages: Homodimer.

289377:HL41 RS03445
gene id: 289377:HL41_RS03445
uniprot id: A0A075WU55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

289377:HL41 RS07545
gene id: 289377:HL41_RS07545
uniprot id: A0A075WUP2
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS05400
gene id: 289377:HL41_RS05400
uniprot id: A0A075WTC3
names: Similarity
messages: Belongs to the aspartokinase family.

289377:HL41 RS05255
gene id: 289377:HL41_RS05255
uniprot id: A0A075WTP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

289377:HL41 RS07065
gene id: 289377:HL41_RS07065
uniprot id: A0A075X0K1
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS01430
gene id: 289377:HL41_RS01430
uniprot id: A0A075WTA4
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

289377:HL41 RS03745
gene id: 289377:HL41_RS03745
uniprot id: A0A075WSY7
names: Similarity
messages: Belongs to the ComB family.

289377:HL41 RS02970
gene id: 289377:HL41_RS02970
uniprot id: A0A075WSK7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

289377:HL41 RS00265
gene id: 289377:HL41_RS00265
uniprot id: A0A075WSK8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

289377:HL41 RS00275
gene id: 289377:HL41_RS00275
uniprot id: A0A075WR16
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS02535
gene id: 289377:HL41_RS02535
uniprot id: A0A075WYQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

289377:HL41 RS08630
gene id: 289377:HL41_RS08630
uniprot id: A0A075WU38
names: Similarity
messages: Belongs to the acylphosphatase family.

289377:HL41 RS05215
gene id: 289377:HL41_RS05215
uniprot id: A0A075WUW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

289377:HL41 RS05160
gene id: 289377:HL41_RS05160
uniprot id: A0A075WZU3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

289377:HL41 RS06950
gene id: 289377:HL41_RS06950
uniprot id: A0A075WUC3
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

289377:HL41 RS03090
gene id: 289377:HL41_RS03090
uniprot id: A0A075WYX9
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS01525
gene id: 289377:HL41_RS01525
uniprot id: A0A075WQM9
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

289377:HL41 RS04570
gene id: 289377:HL41_RS04570
uniprot id: A0A075WT09
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

289377:HL41 RS06550
gene id: 289377:HL41_RS06550
uniprot id: A0A075WVE4
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

289377:HL41 RS01335
gene id: 289377:HL41_RS01335
uniprot id: A0A075WQJ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

289377:HL41 RS02900
gene id: 289377:HL41_RS02900
uniprot id: A0A075WTX2
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

289377:HL41 RS00910
gene id: 289377:HL41_RS00910
uniprot id: A0A075WY44
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS01395
gene id: 289377:HL41_RS01395
uniprot id: A0A075WT97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

289377:HL41 RS04825
gene id: 289377:HL41_RS04825
uniprot id: A0A075WUR5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS08040
gene id: 289377:HL41_RS08040
uniprot id: A0A075WTA2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS03160
gene id: 289377:HL41_RS03160
uniprot id: A0A075WU09
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

289377:HL41 RS03755
gene id: 289377:HL41_RS03755
uniprot id: A0A075WZ78
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS02720
gene id: 289377:HL41_RS02720
uniprot id: A0A075WYS4
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS06155
gene id: 289377:HL41_RS06155
uniprot id: A0A075WSX3
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

289377:HL41 RS03315
gene id: 289377:HL41_RS03315
uniprot id: A0A075WU35
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS08715
gene id: 289377:HL41_RS08715
uniprot id: A0A075WWA3
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

289377:HL41 RS07120
gene id: 289377:HL41_RS07120
uniprot id: A0A075WVN4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

289377:HL41 RS06240
gene id: 289377:HL41_RS06240
uniprot id: A0A075WU36
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

289377:HL41 RS05485
gene id: 289377:HL41_RS05485
uniprot id: A0A075WZY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

289377:HL41 RS04565
gene id: 289377:HL41_RS04565
uniprot id: A0A075WS84
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

289377:HL41 RS08280
gene id: 289377:HL41_RS08280
uniprot id: A0A075WUY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

289377:HL41 RS08365
gene id: 289377:HL41_RS08365
uniprot id: A0A075WUT6
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

289377:HL41 RS04015
gene id: 289377:HL41_RS04015
uniprot id: A0A075WUE1
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

289377:HL41 RS00335
gene id: 289377:HL41_RS00335
uniprot id: A0A075WRB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

289377:HL41 RS07610
gene id: 289377:HL41_RS07610
uniprot id: A0A075WUI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

289377:HL41 RS05435
gene id: 289377:HL41_RS05435
uniprot id: A0A075WZX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

289377:HL41 RS04455
gene id: 289377:HL41_RS04455
uniprot id: A0A075WSY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

289377:HL41 RS05825
gene id: 289377:HL41_RS05825
uniprot id: A0A075X023
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

289377:HL41 RS07680
gene id: 289377:HL41_RS07680
uniprot id: A0A075WUR0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

289377:HL41 RS08430
gene id: 289377:HL41_RS08430
uniprot id: A0A075WUU3
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS03260
gene id: 289377:HL41_RS03260
uniprot id: A0A075WU26
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

289377:HL41 RS06345
gene id: 289377:HL41_RS06345
uniprot id: A0A075WSZ8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS05740
gene id: 289377:HL41_RS05740
uniprot id: A0A075WTK2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

289377:HL41 RS05885
gene id: 289377:HL41_RS05885
uniprot id: A0A075X032
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

289377:HL41 RS00230
gene id: 289377:HL41_RS00230
uniprot id: A0A075WXT8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS00800
gene id: 289377:HL41_RS00800
uniprot id: A0A075WSV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

289377:HL41 RS06830
gene id: 289377:HL41_RS06830
uniprot id: A0A075WYS4
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS04335
gene id: 289377:HL41_RS04335
uniprot id: A0A075WUK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

289377:HL41 RS03925
gene id: 289377:HL41_RS03925
uniprot id: A0A075WSL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

289377:HL41 RS08145
gene id: 289377:HL41_RS08145
uniprot id: A0A075WUQ2
names: Similarity
messages: Belongs to the UbiD family.

289377:HL41 RS00345
gene id: 289377:HL41_RS00345
uniprot id: A0A075WSM1
names: Similarity
messages: Belongs to the cytochrome c-552 family.

289377:HL41 RS07620
gene id: 289377:HL41_RS07620
uniprot id: A0A075X0U7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS00320
gene id: 289377:HL41_RS00320
uniprot id: A0A075WSL7
names: Subcellular Location Annotation
messages: Cytoplasm

289377:HL41 RS07105
gene id: 289377:HL41_RS07105
uniprot id: A0A075WU85
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

289377:HL41 RS07990
gene id: 289377:HL41_RS07990
uniprot id: A0A075WUV5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

289377:HL41 RS07430
gene id: 289377:HL41_RS07430
uniprot id: A0A075WUH6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

289377:HL41 RS00430
gene id: 289377:HL41_RS00430
uniprot id: A0A075WXW9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

289377:HL41 RS01895
gene id: 289377:HL41_RS01895
uniprot id: A0A075WTG3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

289377:HL41 RS03605
gene id: 289377:HL41_RS03605
uniprot id: A0A075WSV8
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

289377:HL41 RS07465
gene id: 289377:HL41_RS07465
uniprot id: A0A075WUH8
names: Similarity
messages: Belongs to the HepT RNase toxin family.

289377:HL41 RS07920
gene id: 289377:HL41_RS07920
uniprot id: A0A075WVZ0
names: Similarity
messages: Belongs to the universal stress protein A family.

289377:HL41 RS07945
gene id: 289377:HL41_RS07945
uniprot id: A0A075WVZ3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

289377:HL41 RS04760
gene id: 289377:HL41_RS04760
uniprot id: A0A075WT27
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

289377:HL41 RS00835
gene id: 289377:HL41_RS00835
uniprot id: A0A075WRB4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

289377:HL41 RS02130
gene id: 289377:HL41_RS02130
uniprot id: A0A075WS72
names: Similarity
messages: Belongs to the UPF0173 family.

289377:HL41 RS03480
gene id: 289377:HL41_RS03480
uniprot id: A0A075WU60
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

289377:HL41 RS05310
gene id: 289377:HL41_RS05310
uniprot id: A0A075WZW4
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

289377:HL41 RS03970
gene id: 289377:HL41_RS03970
uniprot id: A0A075WRT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

289377:HL41 RS03070
gene id: 289377:HL41_RS03070
uniprot id: A0A075WTZ8
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS04325
gene id: 289377:HL41_RS04325
uniprot id: A0A075WTB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

289377:HL41 RS02250
gene id: 289377:HL41_RS02250
uniprot id: A0A075WYL1
names: Similarity
messages: Belongs to the GPI family.

289377:HL41 RS06410
gene id: 289377:HL41_RS06410
uniprot id: A0A075X0A0
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

289377:HL41 RS04385
gene id: 289377:HL41_RS04385
uniprot id: A0A075WZK8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

289377:HL41 RS03310
gene id: 289377:HL41_RS03310
uniprot id: A0A075WZ10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

289377:HL41 RS01040
gene id: 289377:HL41_RS01040
uniprot id: A0A075WRP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

289377:HL41 RS08725
gene id: 289377:HL41_RS08725
uniprot id: A0A075WUY3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

289377:HL41 RS05750
gene id: 289377:HL41_RS05750
uniprot id: A0A075X014
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

289377:HL41 RS07265
gene id: 289377:HL41_RS07265
uniprot id: A0A075WUB4
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

289377:HL41 RS07705
gene id: 289377:HL41_RS07705
uniprot id: A0A075WUR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

289377:HL41 RS02795
gene id: 289377:HL41_RS02795
uniprot id: A0A075WS08
names: Similarity
messages: Belongs to the hemerythrin family.

289377:HL41 RS06030
gene id: 289377:HL41_RS06030
uniprot id: A0A075X054
names: Subcellular Location Annotation
messages: Membrane

289377:HL41 RS05095
gene id: 289377:HL41_RS05095
uniprot id: A0A075WT68
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

289377:HL41 RS05955
gene id: 289377:HL41_RS05955
uniprot id: A0A075WTP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

289377:HL41 RS06110
gene id: 289377:HL41_RS06110
uniprot id: A0A075WTA2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS00395
gene id: 289377:HL41_RS00395
uniprot id: A0A075WRC2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

289377:HL41 RS01905
gene id: 289377:HL41_RS01905
uniprot id: A0A075WRP9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

289377:HL41 RS02255
gene id: 289377:HL41_RS02255
uniprot id: A0A075WTK6
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

289377:HL41 RS02965
gene id: 289377:HL41_RS02965
uniprot id: A0A075WTA2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

289377:HL41 RS00360
gene id: 289377:HL41_RS00360
uniprot id: A0A075WR33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

289377:HL41 RS05010
gene id: 289377:HL41_RS05010
uniprot id: A0A075WT58
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.