284811:AGOS AEL332W
gene id: 284811:AGOS_AEL332W
uniprot id: Q758T4
names: Similarity
messages: Belongs to the FUN14 family.

284811:AGOS AAR093C
gene id: 284811:AGOS_AAR093C
uniprot id: Q75EI6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for proper protein synthesis within the mitochondrion.
messages: Belongs to the GatF family.
messages: Mitochondrion inner membrane
messages: Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

284811:AGOS AER282W
gene id: 284811:AGOS_AER282W
uniprot id: Q756H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

284811:AGOS AFR508W
gene id: 284811:AGOS_AFR508W
uniprot id: Q752R5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AFR365C
gene id: 284811:AGOS_AFR365C
uniprot id: Q753E9
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ADL015C
gene id: 284811:AGOS_ADL015C
uniprot id: Q75AD2
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.

284811:AGOS ACR257C
gene id: 284811:AGOS_ACR257C
uniprot id: Q9P8V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane

284811:AGOS AFR659W
gene id: 284811:AGOS_AFR659W
uniprot id: Q752B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the DnaJ family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity).
messages: Nucleus

284811:AGOS AAR124C
gene id: 284811:AGOS_AAR124C
uniprot id: Q75EF7
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

284811:AGOS AER443W
gene id: 284811:AGOS_AER443W
uniprot id: Q755S5
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AER059C
gene id: 284811:AGOS_AER059C
uniprot id: Q757F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ART10 family.
messages: Cytoplasm
messages: May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.

284811:AGOS ADR338C
gene id: 284811:AGOS_ADR338C
uniprot id: Q759D9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.
messages: Nucleus

284811:AGOS ABR001W
gene id: 284811:AGOS_ABR001W
uniprot id: Q75DL7
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

284811:AGOS ADL254W
gene id: 284811:AGOS_ADL254W
uniprot id: Q75B31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

284811:AGOS AEL139W
gene id: 284811:AGOS_AEL139W
uniprot id: Q757Z9
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

284811:AGOS AER146C
gene id: 284811:AGOS_AER146C
uniprot id: Q756V5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

284811:AGOS ACR278W
gene id: 284811:AGOS_ACR278W
uniprot id: Q75BJ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Mitochondrion
messages: Nucleus

284811:AGOS AAR169C
gene id: 284811:AGOS_AAR169C
uniprot id: Q75EA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

284811:AGOS AMI006W
gene id: 284811:AGOS_AMI006W
uniprot id: Q75G39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 18 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i, j and k.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

284811:AGOS ACR268C
gene id: 284811:AGOS_ACR268C
uniprot id: Q75BK3
names: Similarity
messages: Belongs to the malate synthase family.

284811:AGOS AFL183C
gene id: 284811:AGOS_AFL183C
uniprot id: Q755Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

284811:AGOS ADR084C
gene id: 284811:AGOS_ADR084C
uniprot id: Q75A35
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

284811:AGOS ADR082C
gene id: 284811:AGOS_ADR082C
uniprot id: Q75A37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Regulates the cell cycle in a nutrient dependent manner.

284811:AGOS ADL274W
gene id: 284811:AGOS_ADL274W
uniprot id: Q75B51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB2 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus

284811:AGOS ACL127W
gene id: 284811:AGOS_ACL127W
uniprot id: Q75CP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-HAO family.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
messages: Cytoplasm

284811:AGOS AFR237W
gene id: 284811:AGOS_AFR237W
uniprot id: Q754I0
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ADL205C
gene id: 284811:AGOS_ADL205C
uniprot id: Q75AX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

284811:AGOS AGL335W
gene id: 284811:AGOS_AGL335W
uniprot id: Q751N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
messages: Homodimer.
messages: Mitochondrion inner membrane
messages: Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins (By similarity). Hydrolyzes ATP (By similarity). Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).

284811:AGOS AER451W
gene id: 284811:AGOS_AER451W
uniprot id: Q755R7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NMT1/THI5 family.
messages: Homodimer.
messages: Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

284811:AGOS ACR020C
gene id: 284811:AGOS_ACR020C
uniprot id: Q75C96
names: Similarity
messages: Belongs to the MYBBP1A family.

284811:AGOS ACR192C
gene id: 284811:AGOS_ACR192C
uniprot id: Q75BS9
names: Similarity
messages: Belongs to the WD repeat mio family.

284811:AGOS ABL195C
gene id: 284811:AGOS_ABL195C
uniprot id: Q8NJR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily.
messages: Homodimer.
messages: Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity).

284811:AGOS ABL077W
gene id: 284811:AGOS_ABL077W
uniprot id: Q75DV0
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

284811:AGOS AAL132C
gene id: 284811:AGOS_AAL132C
uniprot id: Q75F60
names: Similarity
messages: Belongs to the DNA polymerase delta/II small subunit family.

284811:AGOS AGR152W
gene id: 284811:AGOS_AGR152W
uniprot id: Q74ZP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.
messages: nucleolus

284811:AGOS ACR068W
gene id: 284811:AGOS_ACR068W
uniprot id: Q75C49
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

284811:AGOS AFR688C
gene id: 284811:AGOS_AFR688C
uniprot id: Q751Y7
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

284811:AGOS ADR014W
gene id: 284811:AGOS_ADR014W
uniprot id: Q75AA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM21 family.
messages: Involved in mitochondrial migration along actin filaments.
messages: actin patch

284811:AGOS AAL168C
gene id: 284811:AGOS_AAL168C
uniprot id: Q75FA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Mitochondrion inner membrane
messages: Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.

284811:AGOS AAR098W
gene id: 284811:AGOS_AAR098W
uniprot id: Q75EI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

284811:AGOS ADR311C
gene id: 284811:AGOS_ADR311C
uniprot id: Q759G5
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

284811:AGOS AEL219W
gene id: 284811:AGOS_AEL219W
uniprot id: Q758I1
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AAR032W
gene id: 284811:AGOS_AAR032W
uniprot id: Q75EP7
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADR152CA
gene id: 284811:AGOS_ADR152CA
uniprot id: Q759X0
names: Similarity
messages: Belongs to the sulfiredoxin family.

284811:AGOS ADL210W
gene id: 284811:AGOS_ADL210W
uniprot id: Q75AY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

284811:AGOS AAR066W
gene id: 284811:AGOS_AAR066W
uniprot id: Q75EL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

284811:AGOS ADR309W
gene id: 284811:AGOS_ADR309W
uniprot id: Q759G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
messages: Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
messages: Component of the SWR1 chromatin-remodeling complex.
messages: Nucleus

284811:AGOS AFR459W
gene id: 284811:AGOS_AFR459W
uniprot id: Q752W4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

284811:AGOS AFR147C
gene id: 284811:AGOS_AFR147C
uniprot id: Q754C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

284811:AGOS ADR369C
gene id: 284811:AGOS_ADR369C
uniprot id: Q759A8
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

284811:AGOS ADR107W
gene id: 284811:AGOS_ADR107W
uniprot id: Q75A20
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.
messages: Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway.

284811:AGOS AGR223W
gene id: 284811:AGOS_AGR223W
uniprot id: Q74ZH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDE1 family.
messages: Cytoplasm
messages: Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis. Required for utilization of glycerophosphocholine as phosphate source.

284811:AGOS AGL121W
gene id: 284811:AGOS_AGL121W
uniprot id: Q750R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

284811:AGOS AGL260W
gene id: 284811:AGOS_AGL260W
uniprot id: Q751G6
names: Similarity
messages: Belongs to the alkaline phosphatase family.

284811:AGOS AEL152W
gene id: 284811:AGOS_AEL152W
uniprot id: Q758E0
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

284811:AGOS AAL079C
gene id: 284811:AGOS_AAL079C
uniprot id: Q75F07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

284811:AGOS AEL099W
gene id: 284811:AGOS_AEL099W
uniprot id: Q757W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

284811:AGOS ADL007C
gene id: 284811:AGOS_ADL007C
uniprot id: Q75AC4
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AEL193W
gene id: 284811:AGOS_AEL193W
uniprot id: Q758F5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

284811:AGOS AER245C
gene id: 284811:AGOS_AER245C
uniprot id: Q756K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: Cytoplasm
messages: Involved in nuclear export, actin cytoskeleton organization and vesicular transport.
messages: Nucleus

284811:AGOS AGL175W
gene id: 284811:AGOS_AGL175W
uniprot id: Q750W4
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

284811:AGOS AER336C
gene id: 284811:AGOS_AER336C
uniprot id: Q756D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

284811:AGOS ABR008C
gene id: 284811:AGOS_ABR008C
uniprot id: Q75DS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STAM family.
messages: Component of the ESCRT-0 complex composed of HSE1 and VPS27.
messages: Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).
messages: Endosome membrane

284811:AGOS AGR385C
gene id: 284811:AGOS_AGR385C
uniprot id: Q74Z21
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

284811:AGOS AFR593C
gene id: 284811:AGOS_AFR593C
uniprot id: Q752Z5
names: Similarity
messages: Belongs to the FBPase class 1 family.

284811:AGOS AAL166C
gene id: 284811:AGOS_AAL166C
uniprot id: Q75FA5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MMM1 family.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
messages: Endoplasmic reticulum membrane
messages: Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.
messages: The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.

284811:AGOS AGR132W
gene id: 284811:AGOS_AGR132W
uniprot id: Q74ZR6
names: Similarity
messages: In the C-terminal section; belongs to the trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.

284811:AGOS ABR031C
gene id: 284811:AGOS_ABR031C
uniprot id: Q75DJ3
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

284811:AGOS AGR161C
gene id: 284811:AGOS_AGR161C
uniprot id: Q74ZN7
names: Similarity
messages: Belongs to the SPT2 family.

284811:AGOS AER049W
gene id: 284811:AGOS_AER049W
uniprot id: Q757G4
names: Similarity
messages: Belongs to the VAC14 family.

284811:AGOS AGR140C
gene id: 284811:AGOS_AGR140C
uniprot id: Q74ZQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHU2 family.
messages: Nucleus
messages: Plays a role in a RAD51/RAD54-dependent homologous recombination repair (HRR) pathway to repair MMS-induced lesions during S-phase. Required for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation (By similarity).

284811:AGOS ADR021W
gene id: 284811:AGOS_ADR021W
uniprot id: Q75A97
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Cytoplasm
messages: Nucleus

284811:AGOS ADR076C
gene id: 284811:AGOS_ADR076C
uniprot id: Q75A43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly (By similarity).
messages: spindle pole body

284811:AGOS AFL016C
gene id: 284811:AGOS_AFL016C
uniprot id: Q754T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

284811:AGOS ADL124C
gene id: 284811:AGOS_ADL124C
uniprot id: Q75AP4
names: Similarity
messages: Belongs to the UQCRH/QCR6 family.

284811:AGOS AGL073W
gene id: 284811:AGOS_AGL073W
uniprot id: Q750M9
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

284811:AGOS AER075W
gene id: 284811:AGOS_AER075W
uniprot id: Q757D8
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

284811:AGOS ACL054W
gene id: 284811:AGOS_ACL054W
uniprot id: Q75CH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a ternary complex with ATG13 and ATG17.
messages: Preautophagosomal structure membrane
messages: Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.

284811:AGOS ABL203W
gene id: 284811:AGOS_ABL203W
uniprot id: Q75E73
names: Similarity
messages: Belongs to the peptidase S8 family. Furin subfamily.

284811:AGOS AFL082W
gene id: 284811:AGOS_AFL082W
uniprot id: Q755A7
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

284811:AGOS AAL113W
gene id: 284811:AGOS_AAL113W
uniprot id: Q75F41
names: Similarity
messages: Belongs to the AAA ATPase family.

284811:AGOS ADL066C
gene id: 284811:AGOS_ADL066C
uniprot id: O94198
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
messages: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.
messages: Glyoxysome
messages: Homotetramer.

284811:AGOS ADL354W
gene id: 284811:AGOS_ADL354W
uniprot id: Q75BC1
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

284811:AGOS AAR028W
gene id: 284811:AGOS_AAR028W
uniprot id: Q75EQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Mitochondrion inner membrane
messages: Probably involved in the biogenesis of the COX complex.

284811:AGOS AER366W
gene id: 284811:AGOS_AER366W
uniprot id: Q756A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

284811:AGOS AAL095W
gene id: 284811:AGOS_AAL095W
uniprot id: Q75F23
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.
messages: May lack the polyribonucleotide 5'-hydroxyl-kinase and polynucleotide 5'-hydroxyl-kinase activities that are characteristic of the human ortholog.
messages: Nucleus
messages: Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.

284811:AGOS AEL059W
gene id: 284811:AGOS_AEL059W
uniprot id: Q757S1
names: Similarity
messages: Belongs to the OMP decarboxylase family.

284811:AGOS AER409C
gene id: 284811:AGOS_AER409C
uniprot id: Q755V9
names: Function
names: Subcellular Location Annotation
messages: Plays a role in starvation-induced autophagy. Involved in mitophagy. Functions with ATG17 and ATG29 at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. May be involved in microtubule function, such as chromosome segregation and karyogamy (By similarity).
messages: Preautophagosomal structure
messages: cytoskeleton

284811:AGOS AGL177C
gene id: 284811:AGOS_AGL177C
uniprot id: Q750W6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

284811:AGOS ADR055C
gene id: 284811:AGOS_ADR055C
uniprot id: Q75A63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.

284811:AGOS AFR278W
gene id: 284811:AGOS_AFR278W
uniprot id: Q753N4
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

284811:AGOS ACR255C
gene id: 284811:AGOS_ACR255C
uniprot id: Q75BL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).
messages: Cytoplasm
messages: Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability (By similarity).

284811:AGOS ABR014W
gene id: 284811:AGOS_ABR014W
uniprot id: Q75DK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle. Phosphorylates histone H2B to form H2BS10ph (By similarity).
messages: Nucleus

284811:AGOS AFR258W
gene id: 284811:AGOS_AFR258W
uniprot id: Q753R8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

284811:AGOS ABR143C
gene id: 284811:AGOS_ABR143C
uniprot id: Q75D81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EFG1 family.
messages: Involved in rRNA processing.
messages: nucleolus

284811:AGOS AFL021C
gene id: 284811:AGOS_AFL021C
uniprot id: Q754U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex DAD3 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
messages: Nucleus
messages: The DASH complex oligomerizes to form rings that encircle the microtubules.
messages: kinetochore
messages: spindle

284811:AGOS AAR080W
gene id: 284811:AGOS_AAR080W
uniprot id: Q75EJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG22 family.
messages: Membrane
messages: Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.
messages: Vacuole membrane

284811:AGOS AER294C
gene id: 284811:AGOS_AER294C
uniprot id: Q756H2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+) is required for catalysis and for stabilizing the dimer.

284811:AGOS AAL041C
gene id: 284811:AGOS_AAL041C
uniprot id: Q75EW9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
messages: Interacts with the SSU processome.
messages: Nucleus
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

284811:AGOS AGR191W
gene id: 284811:AGOS_AGR191W
uniprot id: Q74ZK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

284811:AGOS AGL008W
gene id: 284811:AGOS_AGL008W
uniprot id: Q750G1
names: Similarity
messages: Belongs to the patched family.

284811:AGOS AFR516W
gene id: 284811:AGOS_AFR516W
uniprot id: Q752Q7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

284811:AGOS AER024W
gene id: 284811:AGOS_AER024W
uniprot id: Q757I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REXO4 family.
messages: Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity).
messages: Nucleus

284811:AGOS AFL198W
gene id: 284811:AGOS_AFL198W
uniprot id: Q755L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus

284811:AGOS ADR132W
gene id: 284811:AGOS_ADR132W
uniprot id: Q759Z1
names: Similarity
messages: Belongs to the multicopper oxidase family.

284811:AGOS ADR292W
gene id: 284811:AGOS_ADR292W
uniprot id: Q759H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

284811:AGOS ACL106C
gene id: 284811:AGOS_ACL106C
uniprot id: Q75CM5
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ABL011C
gene id: 284811:AGOS_ABL011C
uniprot id: Q75DM8
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

284811:AGOS ADR285W
gene id: 284811:AGOS_ADR285W
uniprot id: Q759J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer. Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer. Interacts with the chloride channel protein GEF1.

284811:AGOS AAR107W
gene id: 284811:AGOS_AAR107W
uniprot id: Q75EH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWS1 family.
messages: Nucleus
messages: Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription (By similarity).

284811:AGOS AFR441C
gene id: 284811:AGOS_AFR441C
uniprot id: Q752Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

284811:AGOS AER262C
gene id: 284811:AGOS_AER262C
uniprot id: Q756W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

284811:AGOS AGR148C
gene id: 284811:AGOS_AGR148C
uniprot id: Q74ZQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus

284811:AGOS AGR007C
gene id: 284811:AGOS_AGR007C
uniprot id: Q750E8
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AAR125C
gene id: 284811:AGOS_AAR125C
uniprot id: Q75EF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: Membrane

284811:AGOS AFR411C
gene id: 284811:AGOS_AFR411C
uniprot id: Q753B3
names: Similarity
messages: Belongs to the VPS29 family.

284811:AGOS AGL266C
gene id: 284811:AGOS_AGL266C
uniprot id: Q751H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS ABR056C
gene id: 284811:AGOS_ABR056C
uniprot id: Q75DH0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.

284811:AGOS AER079C
gene id: 284811:AGOS_AER079C
uniprot id: Q757D4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BLOC1S1 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex involved in endosomal cargo sorting.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1).
messages: Endosome

284811:AGOS AEL287C
gene id: 284811:AGOS_AEL287C
uniprot id: Q758V4
names: Similarity
messages: Belongs to the OSBP family.

284811:AGOS AEL001C
gene id: 284811:AGOS_AEL001C
uniprot id: Q8J1F7
names: Similarity
messages: Belongs to the UPF0045 family.

284811:AGOS ADR293CA
gene id: 284811:AGOS_ADR293CA
uniprot id: Q759H1
names: Similarity
messages: Belongs to the SWI5/SAE3 family.

284811:AGOS ADR143W
gene id: 284811:AGOS_ADR143W
uniprot id: Q759Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAR5 family.
messages: Endoplasmic reticulum membrane
messages: Nucleus membrane
messages: Required for nuclear membrane fusion during karyogamy.

284811:AGOS AFR422W
gene id: 284811:AGOS_AFR422W
uniprot id: Q753A2
names: Similarity
messages: Belongs to the activator 1 small subunits family.

284811:AGOS AAL019W
gene id: 284811:AGOS_AAL019W
uniprot id: Q75EU8
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AAL033W
gene id: 284811:AGOS_AAL033W
uniprot id: Q75EW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

284811:AGOS AFR300C
gene id: 284811:AGOS_AFR300C
uniprot id: Q753L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKG1 family.
messages: Bud membrane
messages: Cell membrane
messages: Plays a role in cell wall integrity. Affects the cell wall polymer composition in the growing region of the cell (By similarity).

284811:AGOS AEL067W
gene id: 284811:AGOS_AEL067W
uniprot id: Q757S9
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

284811:AGOS ADL209C
gene id: 284811:AGOS_ADL209C
uniprot id: Q75AX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP25 family.
messages: Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
messages: nucleolus

284811:AGOS ABR041C
gene id: 284811:AGOS_ABR041C
uniprot id: Q75DI4
names: Similarity
messages: Belongs to the universal ribosomal protein uS10 family.

284811:AGOS ABL174C
gene id: 284811:AGOS_ABL174C
uniprot id: Q75E44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family. Ssb-type Hsp70 subfamily.
messages: Binds to ribosomes. Binds close to the ribosomal tunnel exit via contacts with both ribosomal proteins and rRNA. Directly interacts with nascent polypeptides. This interaction is dependent on the ribosome-associated complex (RAC). Interacts with SSE1. Interacts with FES1.
messages: Cytoplasm
messages: Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol. Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation-prone nascent polypeptides and domains that cannot fold stably until fully synthesized. The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD. The ATP-bound state is characterized by a fast exchange rate of substrate (low affinity state), while in the ADP-bound state exchange is much slower (high affinity state). During the Hsp70 cycle, the chaperone switches between the ATP-bound state (open conformation) and the ADP-bound state (closed conformation) by major conformational rearrangements involving mainly the lid domain. Ssb cooperates with a specific Hsp40/Hsp70 co-chaperone termed the ribosome-associated complex (RAC), which stimulates the ATPase activity of the ribosome-associated pool of Ssbs and switches it to the high affinity substrate binding state. Hsp110 chaperone SSE1 and FES1 act as nucleotide exchange factors that cause substrate release.

284811:AGOS ADR063W
gene id: 284811:AGOS_ADR063W
uniprot id: Q75A56
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DP1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Oligomer.
messages: Required to generate and maintain the structure of the tubular endoplasmic reticulum network and the vacuole. Induces high curvature in membranes and causes membrane tubule formation. Involved in membrane/vesicle trafficking.
messages: The short lumenal loops between transmembrane domains 1 and 2 and between transmembrane domains 3 and 4 may impart a wedge-like configuration, thus deforming membranes.

284811:AGOS ADR146C
gene id: 284811:AGOS_ADR146C
uniprot id: Q759X7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.

284811:AGOS AER004W
gene id: 284811:AGOS_AER004W
uniprot id: Q757K8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

284811:AGOS AGR267W
gene id: 284811:AGOS_AGR267W
uniprot id: Q74ZD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for transport from the ER to the Golgi complex.

284811:AGOS AFR251C
gene id: 284811:AGOS_AFR251C
uniprot id: Q753S5
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

284811:AGOS ADR094W
gene id: 284811:AGOS_ADR094W
uniprot id: Q75A26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

284811:AGOS ABR139W
gene id: 284811:AGOS_ABR139W
uniprot id: Q75D85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Nucleus

284811:AGOS AER136W
gene id: 284811:AGOS_AER136W
uniprot id: Q756X8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

284811:AGOS AGL120W
gene id: 284811:AGOS_AGL120W
uniprot id: Q750R2
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

284811:AGOS AGR238C
gene id: 284811:AGOS_AGR238C
uniprot id: Q74ZG9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

284811:AGOS AGL139W
gene id: 284811:AGOS_AGL139W
uniprot id: Q750S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

284811:AGOS AFR465C
gene id: 284811:AGOS_AFR465C
uniprot id: Q752V8
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

284811:AGOS AFR056W
gene id: 284811:AGOS_AFR056W
uniprot id: Q754L6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

284811:AGOS AFR510W
gene id: 284811:AGOS_AFR510W
uniprot id: Q752R3
names: Similarity
messages: Belongs to the acetyltransferase family. GNA1 subfamily.

284811:AGOS AEL048W
gene id: 284811:AGOS_AEL048W
uniprot id: Q757R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.
messages: Vacuole membrane

284811:AGOS AGR195W
gene id: 284811:AGOS_AGR195W
uniprot id: Q74ZK5
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AER455C
gene id: 284811:AGOS_AER455C
uniprot id: Q755R3
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AGL061W
gene id: 284811:AGOS_AGL061W
uniprot id: Q750L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer composed of 2 large adaptins (APL5 and APL6), a medium adaptin (APM3) and a small adaptin (APS3).
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity).

284811:AGOS AFR482W
gene id: 284811:AGOS_AFR482W
uniprot id: Q752U1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

284811:AGOS AGR348W
gene id: 284811:AGOS_AGR348W
uniprot id: Q74Z58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMP52 family.
messages: Membrane
messages: Mitochondrion outer membrane

284811:AGOS ABR134C
gene id: 284811:AGOS_ABR134C
uniprot id: Q75D90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Nuclear serine protease which mediates apoptosis.
messages: Nucleus

284811:AGOS ADR379C
gene id: 284811:AGOS_ADR379C
uniprot id: Q758Z8
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.

284811:AGOS AAR128W
gene id: 284811:AGOS_AAR128W
uniprot id: Q75EF3
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

284811:AGOS ADR119W
gene id: 284811:AGOS_ADR119W
uniprot id: Q75A08
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

284811:AGOS AER269C
gene id: 284811:AGOS_AER269C
uniprot id: Q756J2
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADL292C
gene id: 284811:AGOS_ADL292C
uniprot id: Q75B64
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

284811:AGOS AFR723C
gene id: 284811:AGOS_AFR723C
uniprot id: Q751V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPS2 family.
messages: Cell membrane
messages: Membrane

284811:AGOS AFR137C
gene id: 284811:AGOS_AFR137C
uniprot id: Q754D3
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Octamer of two non-identical subunits IDH1 and IDH2.

284811:AGOS AFR126W
gene id: 284811:AGOS_AFR126W
uniprot id: Q754E4
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR569W
gene id: 284811:AGOS_AFR569W
uniprot id: Q752K5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

284811:AGOS AFL040W
gene id: 284811:AGOS_AFL040W
uniprot id: Q754V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

284811:AGOS ADL366W
gene id: 284811:AGOS_ADL366W
uniprot id: Q75BD2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

284811:AGOS ABL104C
gene id: 284811:AGOS_ABL104C
uniprot id: Q75DX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.
messages: Homodimer.
messages: Mitochondrion matrix

284811:AGOS AAL076W
gene id: 284811:AGOS_AAL076W
uniprot id: Q75F04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

284811:AGOS ACL139W
gene id: 284811:AGOS_ACL139W
uniprot id: Q75CQ8
names: Function
names: Subcellular Location Annotation
messages: Is required for the uptake of Fe(3+) ions. May participate in the transport of electrons from cytoplasm to an extracellular substrate (Fe(3+) ion) via FAD and heme intermediates. Involved in iron homeostasis (By similarity).
messages: Membrane

284811:AGOS AGR005C
gene id: 284811:AGOS_AGR005C
uniprot id: Q750F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YPI1 family.
messages: Nucleus
messages: Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.

284811:AGOS ABR012C
gene id: 284811:AGOS_ABR012C
uniprot id: Q75DK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

284811:AGOS ADR026W
gene id: 284811:AGOS_ADR026W
uniprot id: Q75A92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

284811:AGOS AGL232C
gene id: 284811:AGOS_AGL232C
uniprot id: Q751D8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Diphosphomevalonate decarboxylase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins (By similarity). Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8 (By similarity). The diphosphomevalonate decarboxylase MVD1/ERG19 then produces isopentenyl diphosphate (By similarity). The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity).
messages: Homodimer.

284811:AGOS AGR130W
gene id: 284811:AGOS_AGR130W
uniprot id: Q74ZR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

284811:AGOS ADR035C
gene id: 284811:AGOS_ADR035C
uniprot id: Q75A83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM MRD1 family.
messages: Involved in pre-rRNA processing.
messages: Nucleus

284811:AGOS ACR189C
gene id: 284811:AGOS_ACR189C
uniprot id: Q75BT2
names: Similarity
messages: Belongs to the MIX23 family.

284811:AGOS AFR618C
gene id: 284811:AGOS_AFR618C
uniprot id: Q752F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

284811:AGOS AGR407C
gene id: 284811:AGOS_AGR407C
uniprot id: Q74Z00
names: Similarity
messages: Belongs to the peptidase A1 family.

284811:AGOS AFR643C
gene id: 284811:AGOS_AFR643C
uniprot id: Q752D3
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AEL342W
gene id: 284811:AGOS_AEL342W
uniprot id: Q758U4
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

284811:AGOS ABL111C
gene id: 284811:AGOS_ABL111C
uniprot id: Q75DY4
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

284811:AGOS ADR155C
gene id: 284811:AGOS_ADR155C
uniprot id: Q759W7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates directly with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

284811:AGOS ACL016C
gene id: 284811:AGOS_ACL016C
uniprot id: Q75CC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF4 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription (By similarity).
messages: Nucleus
messages: The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors.

284811:AGOS AGL365C
gene id: 284811:AGOS_AGL365C
uniprot id: Q751Q4
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

284811:AGOS AGR231C
gene id: 284811:AGOS_AGR231C
uniprot id: Q74ZH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

284811:AGOS AER232C
gene id: 284811:AGOS_AER232C
uniprot id: Q756M2
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

284811:AGOS ACR179C
gene id: 284811:AGOS_ACR179C
uniprot id: Q75BU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN12 family.
messages: Component of a COP9 signalosome-like (CSN) complex.
messages: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response (By similarity).
messages: Cytoplasm
messages: Nucleus

284811:AGOS AER397C
gene id: 284811:AGOS_AER397C
uniprot id: Q755X1
names: Similarity
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.

284811:AGOS ACR022W
gene id: 284811:AGOS_ACR022W
uniprot id: Q75C94
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AGR022C
gene id: 284811:AGOS_AGR022C
uniprot id: Q750D3
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

284811:AGOS AER165W
gene id: 284811:AGOS_AER165W
uniprot id: Q756T8
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

284811:AGOS AAL071C
gene id: 284811:AGOS_AAL071C
uniprot id: Q75EZ9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

284811:AGOS AGR292C
gene id: 284811:AGOS_AGR292C
uniprot id: Q74ZF9
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

284811:AGOS ABR051C
gene id: 284811:AGOS_ABR051C
uniprot id: Q75DH5
names: Similarity
messages: Belongs to the polyprenol kinase family.

284811:AGOS AFL005W
gene id: 284811:AGOS_AFL005W
uniprot id: Q754S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

284811:AGOS ADL383W
gene id: 284811:AGOS_ADL383W
uniprot id: Q75BE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat ASA1 family.
messages: Component of the ASTRA chromatin remodeling machinery complex.
messages: Component of the ASTRA complex involved in chromatin remodeling.
messages: Nucleus

284811:AGOS ACL056C
gene id: 284811:AGOS_ACL056C
uniprot id: Q75CH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MND1 family.
messages: Nucleus
messages: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.

284811:AGOS AER015C
gene id: 284811:AGOS_AER015C
uniprot id: Q757J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPase family.
messages: Cytoplasm

284811:AGOS AFR457W
gene id: 284811:AGOS_AFR457W
uniprot id: Q752W6
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

284811:AGOS AAR062C
gene id: 284811:AGOS_AAR062C
uniprot id: Q75EL7
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ABL050W
gene id: 284811:AGOS_ABL050W
uniprot id: Q75DR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP25 family.
messages: Mitochondrion inner membrane
messages: Probable mitochondrial mRNA stabilization factor.

284811:AGOS AFR488W
gene id: 284811:AGOS_AFR488W
uniprot id: Q752T5
names: Similarity
messages: Belongs to the Fmt family.

284811:AGOS AFR649W
gene id: 284811:AGOS_AFR649W
uniprot id: Q752C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

284811:AGOS ACR038W
gene id: 284811:AGOS_ACR038W
uniprot id: Q75C78
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Endoplasmic reticulum lumen
messages: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.
messages: The chaperone activity is regulated by ATP-induced allosteric coupling of the nucleotide-binding (NBD) and substrate-binding (SBD) domains. In the ADP-bound and nucleotide-free (apo) states, the two domains have little interaction. In contrast, in the ATP-bound state the two domains are tightly coupled, which results in drastically accelerated kinetics in both binding and release of polypeptide substrates. J domain-containing co-chaperones stimulate the ATPase activity and are required for efficient substrate recognition.

284811:AGOS AGR147W
gene id: 284811:AGOS_AGR147W
uniprot id: Q74ZQ1
names: Similarity
messages: Belongs to the COG3 family.

284811:AGOS ACR013C
gene id: 284811:AGOS_ACR013C
uniprot id: Q75CE3
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

284811:AGOS AGR271C
gene id: 284811:AGOS_AGR271C
uniprot id: Q74ZC8
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR691W
gene id: 284811:AGOS_AFR691W
uniprot id: Q751Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

284811:AGOS ABR086W
gene id: 284811:AGOS_ABR086W
uniprot id: Q75DE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS AFR678C
gene id: 284811:AGOS_AFR678C
uniprot id: Q751Z7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

284811:AGOS AGR103W
gene id: 284811:AGOS_AGR103W
uniprot id: Q74ZU5
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

284811:AGOS ADL374W
gene id: 284811:AGOS_ADL374W
uniprot id: Q75BD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DIM1 family.
messages: Component of the 25S [U4/U6.U5] tri-snRNP.
messages: Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis (By similarity).
messages: Nucleus

284811:AGOS AAL028W
gene id: 284811:AGOS_AAL028W
uniprot id: Q75EV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
messages: Cytoplasm
messages: Monomer.
messages: Ribosome-dependent ATPase that functions in cytoplasmic translation elongation (By similarity). Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis (By similarity). Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied (By similarity).

284811:AGOS AGR381C
gene id: 284811:AGOS_AGR381C
uniprot id: Q74Z25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the peroxisomal translocation machinery.
messages: Peroxisome membrane

284811:AGOS ACR156W
gene id: 284811:AGOS_ACR156W
uniprot id: Q75BW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase T2 family.
messages: Cytoplasm
messages: Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration (By similarity).
messages: Vacuole lumen

284811:AGOS AER279W
gene id: 284811:AGOS_AER279W
uniprot id: Q756I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CUE1 family.
messages: Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity).
messages: Endoplasmic reticulum membrane
messages: Forms a heterodimer with UBC7.

284811:AGOS AFR452C
gene id: 284811:AGOS_AFR452C
uniprot id: Q752X1
names: Similarity
messages: Belongs to the DEAD box helicase family.

284811:AGOS ABR126W
gene id: 284811:AGOS_ABR126W
uniprot id: Q75D98
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ABR199C
gene id: 284811:AGOS_ABR199C
uniprot id: Q75D23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX20 family.
messages: Involved in the assembly of the cytochrome c oxidase complex.
messages: Mitochondrion inner membrane

284811:AGOS AER459W
gene id: 284811:AGOS_AER459W
uniprot id: Q755Q9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

284811:AGOS AAR180C
gene id: 284811:AGOS_AAR180C
uniprot id: Q75E97
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

284811:AGOS AER442W
gene id: 284811:AGOS_AER442W
uniprot id: Q755S6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM34 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.
messages: Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
messages: Mitochondrion outer membrane
messages: The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.

284811:AGOS ABL033C
gene id: 284811:AGOS_ABL033C
uniprot id: Q75DQ0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

284811:AGOS AFR435W
gene id: 284811:AGOS_AFR435W
uniprot id: Q752Y6
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

284811:AGOS AER373C
gene id: 284811:AGOS_AER373C
uniprot id: Q755Z4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

284811:AGOS AFR045W
gene id: 284811:AGOS_AFR045W
uniprot id: Q754M7
names: Similarity
messages: Belongs to the peptidase M14 family.

284811:AGOS AFR680W
gene id: 284811:AGOS_AFR680W
uniprot id: Q751Z5
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

284811:AGOS AEL211W
gene id: 284811:AGOS_AEL211W
uniprot id: Q758H3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

284811:AGOS AAR065C
gene id: 284811:AGOS_AAR065C
uniprot id: Q75EL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Sterol O-acyltransferase that catalyzes the formation of stery esters.

284811:AGOS AAL125W
gene id: 284811:AGOS_AAL125W
uniprot id: Q75F53
names: Function
names: Subcellular Location Annotation
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus

284811:AGOS AFL066C
gene id: 284811:AGOS_AFL066C
uniprot id: Q754Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LCL3 family.
messages: Membrane
messages: Mitochondrion

284811:AGOS AGR230W
gene id: 284811:AGOS_AGR230W
uniprot id: Q74ZH7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GTPase-activating protein (GAP) for CDC42 and less efficiently for RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase (By similarity).

284811:AGOS AEL154C
gene id: 284811:AGOS_AEL154C
uniprot id: Q758A6
names: Similarity
messages: Belongs to the peptidase M20A family.

284811:AGOS AER263C
gene id: 284811:AGOS_AER263C
uniprot id: Q756W4
names: Subcellular Location Annotation
messages: nucleolus

284811:AGOS AEL310C
gene id: 284811:AGOS_AEL310C
uniprot id: Q758R3
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

284811:AGOS AGR309C
gene id: 284811:AGOS_AGR309C
uniprot id: Q74Z94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

284811:AGOS ADL026W
gene id: 284811:AGOS_ADL026W
uniprot id: Q75AE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

284811:AGOS AER123W
gene id: 284811:AGOS_AER123W
uniprot id: Q756Z1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

284811:AGOS AFR526C
gene id: 284811:AGOS_AFR526C
uniprot id: Q752P7
names: Function
names: Similarity
messages: Belongs to the MBF1 family.
messages: Transcriptional coactivator that stimulates transcriptional activity by bridging regulatory proteins and TBP, thereby recruiting TBP to promoters occupied by DNA-binding regulators.

284811:AGOS ADR280W
gene id: 284811:AGOS_ADR280W
uniprot id: Q759J7
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

284811:AGOS AGL329C
gene id: 284811:AGOS_AGL329C
uniprot id: Q751M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LIP1 family.
messages: Component of the ceramide synthase complex required for synthesis of ceramides.
messages: Component of the ceramide synthase complex.
messages: Endoplasmic reticulum membrane

284811:AGOS AFR590W
gene id: 284811:AGOS_AFR590W
uniprot id: Q752I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRE9/KNH1 family.
messages: Involved in cell wall beta(1->6) glucan synthesis.
messages: cell wall

284811:AGOS AFR576C
gene id: 284811:AGOS_AFR576C
uniprot id: Q752J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT4 family.
messages: Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II (By similarity).
messages: Nucleus
messages: The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
messages: centromere

284811:AGOS AFR466C
gene id: 284811:AGOS_AFR466C
uniprot id: Q752V7
names: Similarity
messages: Belongs to the isochorismatase family.

284811:AGOS ADL216C
gene id: 284811:AGOS_ADL216C
uniprot id: Q75AY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

284811:AGOS ACR092C
gene id: 284811:AGOS_ACR092C
uniprot id: Q75C25
names: Similarity
messages: Belongs to the syntaxin family.

284811:AGOS AFR486C
gene id: 284811:AGOS_AFR486C
uniprot id: Q752T7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 3 family.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS ADL283W
gene id: 284811:AGOS_ADL283W
uniprot id: Q75BH1
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

284811:AGOS AGL130C
gene id: 284811:AGOS_AGL130C
uniprot id: Q750R9
names: Function
names: Similarity
messages: Belongs to the SEC10 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

284811:AGOS ABR062W
gene id: 284811:AGOS_ABR062W
uniprot id: Q75DG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BLI1 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1).
messages: Endosome

284811:AGOS ADR283W
gene id: 284811:AGOS_ADR283W
uniprot id: Q759J4
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

284811:AGOS AEL291C
gene id: 284811:AGOS_AEL291C
uniprot id: Q758P4
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ABR020W
gene id: 284811:AGOS_ABR020W
uniprot id: Q75DK1
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Required for transport of secretory proteins from the Golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro (By similarity).

284811:AGOS AER173C
gene id: 284811:AGOS_AER173C
uniprot id: Q756T0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

284811:AGOS ABR214C
gene id: 284811:AGOS_ABR214C
uniprot id: Q75D08
names: Similarity
messages: Belongs to the RICTOR family.

284811:AGOS ADL186C
gene id: 284811:AGOS_ADL186C
uniprot id: Q75AV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat RTC1 family.
messages: May be involved in a process influencing telomere capping.
messages: Vacuole

284811:AGOS ADL202C
gene id: 284811:AGOS_ADL202C
uniprot id: Q757N1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of histone H3 leads to transcriptional activation. H3K14ac formation by GCN5 is promoted by H3S10ph. H3K14ac can also be formed by ESA1. H3K56ac formation occurs predominantly in newly synthesized H3 molecules during G1, S and G2/M of the cell cycle and may be involved in DNA repair (By similarity).
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Mono-, di- and trimethylated by the COMPASS complex to form H3K4me1/2/3. H3K4me activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance. H3K4me enrichment correlates with transcription levels, and occurs in a 5' to 3' gradient with H3K4me3 enrichment at the 5'-end of genes, shifting to H3K4me2 and then H3K4me1. Methylated by SET2 to form H3K36me. H3K36me represses gene expression. Methylated by DOT1 to form H3K79me. H3K79me is required for association of SIR proteins with telomeric regions and for telomeric silencing. The COMPASS-mediated formation of H3K4me2/3 and the DOT1-mediated formation of H3K79me require H2BK123ub1 (By similarity).
messages: Nucleus
messages: Phosphorylated by IPL1 to form H3S10ph. H3S10ph promotes subsequent H3K14ac formation by GCN5 and is required for transcriptional activation through TBP recruitment to the promoters (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me1 = monomethylated Lys-10; H3S10ph = phosphorylated Ser-11; H3K14ac = acetylated Lys-15; H3K14me2 = dimethylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K27ac = acetylated Lys-28; H3K27me1/2/3 = mono-, di- and trimethylated Lys-28; H3K36ac = acetylated Lys-37; H3K36me1/2/3 = mono-, di- and trimethylated Lys-37; H3K56ac = acetylated Lys-57; H3K64ac = acetylated Lys-65; H3K79me1/2/3 = mono-, di- and trimethylated Lys-80.

284811:AGOS ADR321C
gene id: 284811:AGOS_ADR321C
uniprot id: Q759F5
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AEL178C
gene id: 284811:AGOS_AEL178C
uniprot id: Q758D0
names: Similarity
messages: Belongs to the VPS26 family.

284811:AGOS AGR278C
gene id: 284811:AGOS_AGR278C
uniprot id: Q74ZC1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

284811:AGOS AGL017W
gene id: 284811:AGOS_AGL017W
uniprot id: Q750H0
names: Similarity
messages: Belongs to the NEMF family.

284811:AGOS AEL252C
gene id: 284811:AGOS_AEL252C
uniprot id: Q758L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS AEL210C
gene id: 284811:AGOS_AEL210C
uniprot id: Q758H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS ACR104C
gene id: 284811:AGOS_ACR104C
uniprot id: Q75C13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

284811:AGOS ACL006W
gene id: 284811:AGOS_ACL006W
uniprot id: Q75CB5
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

284811:AGOS ABL081W
gene id: 284811:AGOS_ABL081W
uniprot id: Q75DV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIR3 family.
messages: Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.
messages: Nucleus

284811:AGOS ADR068W
gene id: 284811:AGOS_ADR068W
uniprot id: Q75A51
names: Similarity
messages: Belongs to the cyclin family.

284811:AGOS AFR609C
gene id: 284811:AGOS_AFR609C
uniprot id: Q752G7
names: Function
names: Similarity
messages: Belongs to the LplA family.
messages: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.

284811:AGOS AFL104W
gene id: 284811:AGOS_AFL104W
uniprot id: Q755C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

284811:AGOS ACR292W
gene id: 284811:AGOS_ACR292W
uniprot id: Q75BH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LTE1 family.
messages: Bud
messages: Cytoplasm
messages: GDP-GTP exchange factor component of the mitotic exit network (MEN). Fine-tunes the timing of the mitotic exit and couples this event with cytokinesis. May also be involved in proprotein-processing in the secretory pathway (By similarity).

284811:AGOS ADL120C
gene id: 284811:AGOS_ADL120C
uniprot id: Q75B05
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

284811:AGOS AFR413C
gene id: 284811:AGOS_AFR413C
uniprot id: Q753B1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL27 family.

284811:AGOS AFR113W
gene id: 284811:AGOS_AFR113W
uniprot id: Q754F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

284811:AGOS AER003C
gene id: 284811:AGOS_AER003C
uniprot id: Q757K9
names: Similarity
messages: Belongs to the UPP synthase family.

284811:AGOS AEL060C
gene id: 284811:AGOS_AEL060C
uniprot id: Q757S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

284811:AGOS AGR236W
gene id: 284811:AGOS_AGR236W
uniprot id: Q74ZH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Nucleus

284811:AGOS AAL060W
gene id: 284811:AGOS_AAL060W
uniprot id: Q75EY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFT1 family.
messages: Nucleus
messages: RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity).

284811:AGOS AEL131C
gene id: 284811:AGOS_AEL131C
uniprot id: Q757Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 4 family.
messages: Membrane

284811:AGOS AFR035W
gene id: 284811:AGOS_AFR035W
uniprot id: Q754N7
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.
messages: Protein kinase that seems to play a role in the regulation of cell morphogenesis and proliferation.

284811:AGOS AAR157C
gene id: 284811:AGOS_AAR157C
uniprot id: Q75EB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

284811:AGOS AGL091W
gene id: 284811:AGOS_AGL091W
uniprot id: Q751B6
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AFR359C
gene id: 284811:AGOS_AFR359C
uniprot id: Q753F5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

284811:AGOS ADL151W
gene id: 284811:AGOS_ADL151W
uniprot id: Q75AS1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-21 family.
messages: Interacts with PEX7.
messages: Mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 (By similarity). Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (By similarity). PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX21 (By similarity).
messages: Monoubiquitinated at Cys-4; acts as a signal for PEX21 extraction and is required for proper export from peroxisomes and recycling.
messages: Peroxisome
messages: cytosol

284811:AGOS AAL009C
gene id: 284811:AGOS_AAL009C
uniprot id: Q75ET3
names: Similarity
messages: Belongs to the WD repeat LST8 family.

284811:AGOS AFR338W
gene id: 284811:AGOS_AFR338W
uniprot id: Q753H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool (By similarity).
messages: Belongs to the complex I LYR family. MZM1 subfamily.
messages: Interacts with RIP1.
messages: Mitochondrion matrix

284811:AGOS AER361C
gene id: 284811:AGOS_AER361C
uniprot id: Q756A6
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.

284811:AGOS AER295C
gene id: 284811:AGOS_AER295C
uniprot id: Q756H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

284811:AGOS ADL323C
gene id: 284811:AGOS_ADL323C
uniprot id: Q75B93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus

284811:AGOS AFL084W
gene id: 284811:AGOS_AFL084W
uniprot id: Q755A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPS2 family.
messages: Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication.
messages: Nucleus membrane
messages: spindle pole body

284811:AGOS AFR643WA
gene id: 284811:AGOS_AFR643WA
uniprot id: Q755R3
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ACL027C
gene id: 284811:AGOS_ACL027C
uniprot id: Q75CD6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a COP9 signalosome-like (CSN) complex.
messages: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes The CSN complex is involved in the regulation of the mating pheromone response. PCI8 may also be involved in transcriptional and translational control (By similarity).
messages: Cytoplasm
messages: Nucleus

284811:AGOS ABR063C
gene id: 284811:AGOS_ABR063C
uniprot id: Q75DG3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

284811:AGOS AFR521W
gene id: 284811:AGOS_AFR521W
uniprot id: Q752Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.

284811:AGOS AEL114C
gene id: 284811:AGOS_AEL114C
uniprot id: Q757X6
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADL005C
gene id: 284811:AGOS_ADL005C
uniprot id: Q75AC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VAB2 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1 and VAB2.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Vacuole

284811:AGOS AFR339W
gene id: 284811:AGOS_AFR339W
uniprot id: Q753H3
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

284811:AGOS AFR523C
gene id: 284811:AGOS_AFR523C
uniprot id: Q752Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CybS family.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS AGR405C
gene id: 284811:AGOS_AGR405C
uniprot id: Q74Z02
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

284811:AGOS AGR325C
gene id: 284811:AGOS_AGR325C
uniprot id: Q74Z81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS1 family.
messages: Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex (By similarity).
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.
messages: Endoplasmic reticulum membrane

284811:AGOS AGR265W
gene id: 284811:AGOS_AGR265W
uniprot id: Q74ZD4
names: Similarity
messages: Belongs to the GET4 family.

284811:AGOS AGR120C
gene id: 284811:AGOS_AGR120C
uniprot id: Q74ZS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

284811:AGOS AFR402C
gene id: 284811:AGOS_AFR402C
uniprot id: Q753Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Nucleus

284811:AGOS ACR248W
gene id: 284811:AGOS_ACR248W
uniprot id: Q75BM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS ADL191W
gene id: 284811:AGOS_ADL191W
uniprot id: Q75AW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion matrix

284811:AGOS AER122C
gene id: 284811:AGOS_AER122C
uniprot id: Q756Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIF1/spd1 family.
messages: Cytoplasm
messages: Mediates the nuclear localization of the ribonucleotide reductase.
messages: Nucleus

284811:AGOS ACR232C
gene id: 284811:AGOS_ACR232C
uniprot id: Q75BN9
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

284811:AGOS AAL135C
gene id: 284811:AGOS_AAL135C
uniprot id: Q75F63
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

284811:AGOS AAL161W
gene id: 284811:AGOS_AAL161W
uniprot id: Q75FA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

284811:AGOS AGR168W
gene id: 284811:AGOS_AGR168W
uniprot id: Q74ZN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

284811:AGOS AAL062W
gene id: 284811:AGOS_AAL062W
uniprot id: Q75EZ0
names: Similarity
messages: Belongs to the PIH1 family.

284811:AGOS AAR051C
gene id: 284811:AGOS_AAR051C
uniprot id: Q75EM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

284811:AGOS AER253W
gene id: 284811:AGOS_AER253W
uniprot id: P62499
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DSS1/SEM1 family.
messages: Part of the 26S proteasome.
messages: Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis.

284811:AGOS AAR009W
gene id: 284811:AGOS_AAR009W
uniprot id: Q75ES0
names: Similarity
messages: Belongs to the protein kinase superfamily.

284811:AGOS ADR215C
gene id: 284811:AGOS_ADR215C
uniprot id: Q759Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

284811:AGOS AGL195C
gene id: 284811:AGOS_AGL195C
uniprot id: Q750Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

284811:AGOS ACR194C
gene id: 284811:AGOS_ACR194C
uniprot id: Q75BS7
names: Function
names: Similarity
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.

284811:AGOS AAL073W
gene id: 284811:AGOS_AAL073W
uniprot id: Q75F01
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

284811:AGOS ACR173W
gene id: 284811:AGOS_ACR173W
uniprot id: Q75BU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

284811:AGOS AGL358C
gene id: 284811:AGOS_AGL358C
uniprot id: Q751P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YME2 family.
messages: Mitochondrion inner membrane
messages: Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA (By similarity).

284811:AGOS AFR183C
gene id: 284811:AGOS_AFR183C
uniprot id: Q753Y9
names: Similarity
messages: Belongs to the Rab GDI family.

284811:AGOS AGL155W
gene id: 284811:AGOS_AGL155W
uniprot id: Q750U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation), facilitation of DNA opening and initiation of transcription. SAGA is required for recruitment of the basal transcription machinery. SLIK is proposed to have partly overlapping functions with SAGA.
messages: Nucleus

284811:AGOS ADL340W
gene id: 284811:AGOS_ADL340W
uniprot id: Q75BA7
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

284811:AGOS ABR114C
gene id: 284811:AGOS_ABR114C
uniprot id: Q75DB0
names: Similarity
messages: Belongs to the oxoprolinase family.

284811:AGOS ABR087C
gene id: 284811:AGOS_ABR087C
uniprot id: Q75DE0
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

284811:AGOS ABL206C
gene id: 284811:AGOS_ABL206C
uniprot id: Q75E77
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.

284811:AGOS AAR146W
gene id: 284811:AGOS_AAR146W
uniprot id: Q75EC8
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

284811:AGOS ADR165C
gene id: 284811:AGOS_ADR165C
uniprot id: Q759V7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

284811:AGOS AGR180W
gene id: 284811:AGOS_AGR180W
uniprot id: Q74ZL8
names: Subcellular Location Annotation
messages: nucleolus

284811:AGOS AFR362C
gene id: 284811:AGOS_AFR362C
uniprot id: Q753F2
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

284811:AGOS ACL121C
gene id: 284811:AGOS_ACL121C
uniprot id: Q75CP0
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

284811:AGOS AFR429C
gene id: 284811:AGOS_AFR429C
uniprot id: Q752Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).

284811:AGOS AFR043W
gene id: 284811:AGOS_AFR043W
uniprot id: Q754M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AER084W
gene id: 284811:AGOS_AER084W
uniprot id: Q757C9
names: Similarity
messages: Belongs to the SRR1 family.

284811:AGOS ABL127W
gene id: 284811:AGOS_ABL127W
uniprot id: Q75E00
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This promotes the activity of RNA polymerase II.

284811:AGOS AFR089W
gene id: 284811:AGOS_AFR089W
uniprot id: Q754I5
names: Similarity
messages: Belongs to the SAPS family.

284811:AGOS AGR284W
gene id: 284811:AGOS_AGR284W
uniprot id: Q74ZB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.

284811:AGOS AGR277W
gene id: 284811:AGOS_AGR277W
uniprot id: Q74ZC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

284811:AGOS ABL014C
gene id: 284811:AGOS_ABL014C
uniprot id: Q75DN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

284811:AGOS ACR112C
gene id: 284811:AGOS_ACR112C
uniprot id: Q75C07
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NifU family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the core Fe-S cluster (ISC) assembly machinery.
messages: Mitochondrion matrix
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISU1. In a second step, the cluster is released from ISU1, transferred to a glutaredoxin, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISU1 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH.

284811:AGOS AER422C
gene id: 284811:AGOS_AER422C
uniprot id: Q755U6
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

284811:AGOS AER026C
gene id: 284811:AGOS_AER026C
uniprot id: Q757I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMT2 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.
messages: nucleolus

284811:AGOS AGR228C
gene id: 284811:AGOS_AGR228C
uniprot id: Q74ZW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

284811:AGOS ADL080W
gene id: 284811:AGOS_ADL080W
uniprot id: Q75AK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

284811:AGOS ADL263W
gene id: 284811:AGOS_ADL263W
uniprot id: Q75B40
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

284811:AGOS AAR031W
gene id: 284811:AGOS_AAR031W
uniprot id: Q75EP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).

284811:AGOS AER087C
gene id: 284811:AGOS_AER087C
uniprot id: Q757C6
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

284811:AGOS ACL064C
gene id: 284811:AGOS_ACL064C
uniprot id: Q75CI3
names: Function
names: Similarity
messages: Belongs to the VPS13 family.
messages: Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.

284811:AGOS ABL094W
gene id: 284811:AGOS_ABL094W
uniprot id: Q75DW7
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.

284811:AGOS ACR291C
gene id: 284811:AGOS_ACR291C
uniprot id: Q75BI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDB19 family.
messages: Cytoplasm
messages: Golgi apparatus
messages: May be involved in protein-linked oligosaccharide phosphorylation.

284811:AGOS AER108C
gene id: 284811:AGOS_AER108C
uniprot id: Q757A5
names: Cofactor
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cu(2+) or Zn(2+).
messages: Mitochondrion inner membrane
messages: Monomer.
messages: Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
messages: The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria.

284811:AGOS ADL310W
gene id: 284811:AGOS_ADL310W
uniprot id: Q75B82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NHP6 family.
messages: Chromosome
messages: DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex (By similarity).
messages: Nucleus
messages: Weakly associates with the stable SPT16-POB3 heterodimer to form the FACT complex.

284811:AGOS AEL292W
gene id: 284811:AGOS_AEL292W
uniprot id: Q758P5
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ADL118C
gene id: 284811:AGOS_ADL118C
uniprot id: Q75AP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tim44 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion inner membrane

284811:AGOS ADL024C
gene id: 284811:AGOS_ADL024C
uniprot id: Q75AE1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
messages: Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

284811:AGOS AFL020W
gene id: 284811:AGOS_AFL020W
uniprot id: Q754U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

284811:AGOS ACL045W
gene id: 284811:AGOS_ACL045W
uniprot id: Q75CG4
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

284811:AGOS AGL090W
gene id: 284811:AGOS_AGL090W
uniprot id: Q750P0
names: Similarity
messages: Belongs to the AHA1 family.

284811:AGOS AGR345C
gene id: 284811:AGOS_AGR345C
uniprot id: Q74Z61
names: Similarity
messages: Belongs to the Tom22 family.

284811:AGOS AER342C
gene id: 284811:AGOS_AER342C
uniprot id: Q756C5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the palA/RIM20 family.
messages: Interacts with RIM101 by binding to its two YPX[LI] motifs.
messages: Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. May act as a scaffold protein that recruits the calpain-like protease RIM13 via VPS32 to its substrate RIM101 (By similarity).

284811:AGOS AFL139W
gene id: 284811:AGOS_AFL139W
uniprot id: Q755G2
names: Similarity
messages: Belongs to the syntaxin family.

284811:AGOS ADR290W
gene id: 284811:AGOS_ADR290W
uniprot id: Q759I7
names: Cofactor
names: Similarity
messages: Belongs to the glutamate synthase family.
messages: Binds 1 [3Fe-4S] cluster.

284811:AGOS AER326C
gene id: 284811:AGOS_AER326C
uniprot id: Q756E1
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus
messages: Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3.

284811:AGOS AFR597W
gene id: 284811:AGOS_AFR597W
uniprot id: Q752H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 85 family.
messages: cytosol

284811:AGOS ACL125C
gene id: 284811:AGOS_ACL125C
uniprot id: Q75CP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

284811:AGOS AFR579W
gene id: 284811:AGOS_AFR579W
uniprot id: Q752J5
names: Miscellaneous
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.
messages: There are two genes for S22 in A.gossypii.

284811:AGOS AGR331C
gene id: 284811:AGOS_AGR331C
uniprot id: Q74Z75
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: Cytoplasm
messages: Nucleus
messages: This protein is considered an atypical serine/threonine kinase, because it lacks the conventional structural elements necessary for the substrate recognition as well as a lysine residue that in all other serine/threonine kinases participates in the catalytic event (By similarity). BUD32 has protein kinase activity in vitro, but in the context of the EKC/KEOPS complex, the catalytic subunit KAE1 switches the activity of BUD32 from kinase into ATPase (By similarity).
messages: telomere

284811:AGOS AFL113C
gene id: 284811:AGOS_AFL113C
uniprot id: Q755D6
names: Subcellular Location Annotation
messages: nucleolus

284811:AGOS AAL044C
gene id: 284811:AGOS_AAL044C
uniprot id: Q75EX2
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

284811:AGOS AER275C
gene id: 284811:AGOS_AER275C
uniprot id: Q756I6
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

284811:AGOS ABR006W
gene id: 284811:AGOS_ABR006W
uniprot id: Q75DS5
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AEL004W
gene id: 284811:AGOS_AEL004W
uniprot id: Q757L5
names: Similarity
messages: Belongs to the RMD1/sif2 family.

284811:AGOS AFR743W
gene id: 284811:AGOS_AFR743W
uniprot id: Q751T2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

284811:AGOS AGR004W
gene id: 284811:AGOS_AGR004W
uniprot id: Q750F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: nuclear pore complex

284811:AGOS AFL017W
gene id: 284811:AGOS_AFL017W
uniprot id: Q754T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWC5 family.
messages: Component of the SWR1 chromatin remodeling complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
messages: Nucleus

284811:AGOS AGR066W
gene id: 284811:AGOS_AGR066W
uniprot id: Q74ZZ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: In the 2nd section; belongs to the EPSP synthase family.
messages: In the 3rd section; belongs to the shikimate kinase family.
messages: In the 4th section; belongs to the type-I 3-dehydroquinase family.
messages: In the C-terminal section; belongs to the shikimate dehydrogenase family.
messages: In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.

284811:AGOS ADL057W
gene id: 284811:AGOS_ADL057W
uniprot id: Q75AI4
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

284811:AGOS AGR370W
gene id: 284811:AGOS_AGR370W
uniprot id: Q74Z36
names: Similarity
messages: Belongs to the peptidase C19 family.

284811:AGOS ADR206W
gene id: 284811:AGOS_ADR206W
uniprot id: Q759R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Cytoplasm

284811:AGOS AFR327C
gene id: 284811:AGOS_AFR327C
uniprot id: Q753I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

284811:AGOS AFR321C
gene id: 284811:AGOS_AFR321C
uniprot id: Q753J1
names: Function
names: Subcellular Location Annotation
messages: Involved in the mitochondrial expression of subunits 6 and 8 of the F0-F1 ATP synthase.
messages: Mitochondrion membrane

284811:AGOS ACR197W
gene id: 284811:AGOS_ACR197W
uniprot id: Q75BS4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping by activating the decapping enzyme DCP1. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity).
messages: Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
messages: P-body
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

284811:AGOS AGL255W
gene id: 284811:AGOS_AGL255W
uniprot id: Q751G1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGF11 family.
messages: Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with SGF73, SUS1 and UBP8.
messages: Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B.
messages: Nucleus
messages: The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of UBP8 forms the 'catalytic lobe' of the SAGA deubiquitination module.
messages: The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.

284811:AGOS ADR048W
gene id: 284811:AGOS_ADR048W
uniprot id: Q75A70
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

284811:AGOS AGL316W
gene id: 284811:AGOS_AGL316W
uniprot id: Q751S0
names: Similarity
messages: Belongs to the peptidase C12 family.

284811:AGOS AER215W
gene id: 284811:AGOS_AER215W
uniprot id: Q756N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

284811:AGOS AER030C
gene id: 284811:AGOS_AER030C
uniprot id: Q757I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

284811:AGOS AFR012C
gene id: 284811:AGOS_AFR012C
uniprot id: Q754R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

284811:AGOS AFR114W
gene id: 284811:AGOS_AFR114W
uniprot id: Q754F6
names: Similarity
messages: Belongs to the heat shock protein 70 family.

284811:AGOS ADR148W
gene id: 284811:AGOS_ADR148W
uniprot id: Q759X5
names: Similarity
messages: Belongs to the SURF6 family.

284811:AGOS AGR342C
gene id: 284811:AGOS_AGR342C
uniprot id: P62511
names: Function
names: Similarity
messages: Belongs to the uridine kinase family. NRK subfamily.
messages: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).

284811:AGOS AFL109W
gene id: 284811:AGOS_AFL109W
uniprot id: Q755D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

284811:AGOS ACR009W
gene id: 284811:AGOS_ACR009W
uniprot id: Q75CA3
names: Similarity
messages: Belongs to the NPR2 family.

284811:AGOS AAR185W
gene id: 284811:AGOS_AAR185W
uniprot id: Q75E95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex DAD1 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
messages: Nucleus
messages: The DASH complex oligomerizes to form rings that encircle the microtubules.
messages: kinetochore
messages: spindle

284811:AGOS ABR156W
gene id: 284811:AGOS_ABR156W
uniprot id: Q75D67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

284811:AGOS AFR469W
gene id: 284811:AGOS_AFR469W
uniprot id: Q752V4
names: Similarity
messages: Belongs to the SNAP-25 family.

284811:AGOS ABR113C
gene id: 284811:AGOS_ABR113C
uniprot id: Q75DB3
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADL144C
gene id: 284811:AGOS_ADL144C
uniprot id: Q75AR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC25 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

284811:AGOS AFR264W
gene id: 284811:AGOS_AFR264W
uniprot id: Q753P8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.

284811:AGOS ACR253C
gene id: 284811:AGOS_ACR253C
uniprot id: Q75BL8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity).
messages: Cytoplasm
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

284811:AGOS AGR221W
gene id: 284811:AGOS_AGR221W
uniprot id: Q74ZI1
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

284811:AGOS AGL352W
gene id: 284811:AGOS_AGL352W
uniprot id: Q751P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

284811:AGOS ADR163W
gene id: 284811:AGOS_ADR163W
uniprot id: Q759V9
names: Similarity
messages: Belongs to the protein kinase superfamily.

284811:AGOS AAL098W
gene id: 284811:AGOS_AAL098W
uniprot id: Q75F26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG29 family.
messages: Plays a role in autophagy. Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Also plays a role in mitophagy and regulation of filamentous growth (By similarity).
messages: Preautophagosomal structure

284811:AGOS AEL316W
gene id: 284811:AGOS_AEL316W
uniprot id: Q758R9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: Cytoplasm
messages: Nucleus

284811:AGOS AGR052C
gene id: 284811:AGOS_AGR052C
uniprot id: Q750A5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA.
messages: Belongs to the REXO1/REXO3 family.
messages: Cytoplasm
messages: Nucleus

284811:AGOS ADL158C
gene id: 284811:AGOS_ADL158C
uniprot id: Q75AS8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

284811:AGOS AER118C
gene id: 284811:AGOS_AER118C
uniprot id: Q756Z5
names: Similarity
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.
messages: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

284811:AGOS AGR206C
gene id: 284811:AGOS_AGR206C
uniprot id: Q74ZW3
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

284811:AGOS ACL078W
gene id: 284811:AGOS_ACL078W
uniprot id: Q75CJ7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

284811:AGOS ABL102C
gene id: 284811:AGOS_ABL102C
uniprot id: Q75DX5
names: Similarity
messages: Belongs to the class-I DAHP synthase family.

284811:AGOS ADR193W
gene id: 284811:AGOS_ADR193W
uniprot id: Q759T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). Also a component of the nuclear pore complex (By similarity).
messages: Belongs to the dynein light chain family.
messages: Homodimer. Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs). Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.
messages: cytoskeleton
messages: nuclear pore complex

284811:AGOS AFR184C
gene id: 284811:AGOS_AFR184C
uniprot id: Q753Y8
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

284811:AGOS ACR031W
gene id: 284811:AGOS_ACR031W
uniprot id: Q75C85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

284811:AGOS AFR018C
gene id: 284811:AGOS_AFR018C
uniprot id: Q754Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS10-related sortilin family.
messages: Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity).
messages: Prevacuolar compartment membrane
messages: trans-Golgi network membrane

284811:AGOS AAR184W
gene id: 284811:AGOS_AAR184W
uniprot id: Q75E96
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

284811:AGOS AER128W
gene id: 284811:AGOS_AER128W
uniprot id: Q756Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Involved in the maintenance of ribosomal (rDNA). Required for efficient fork arrest at the replicaion fork barrier within rDNA. Involved in the maintenance of mitochondrial (mtDNA). Required to maintain mtDNA under conditions that introduce dsDNA breaks in mtDNA, either preventing or repairing dsDNA breaks. May inhibit replication progression to allow time for repair. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. May have a role in conjunction with DNA2 helicase/nuclease in 5'-flap extension during Okazaki fragment processing.
messages: Mitochondrion
messages: Monomer. Interacts with telomerase.
messages: Nucleus

284811:AGOS ABL044C
gene id: 284811:AGOS_ABL044C
uniprot id: Q75DR1
names: Subcellular Location Annotation
messages: nucleolus

284811:AGOS ADL229W
gene id: 284811:AGOS_ADL229W
uniprot id: Q75AZ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.
messages: Cytoplasm

284811:AGOS ACR017W
gene id: 284811:AGOS_ACR017W
uniprot id: Q75C99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
messages: Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.
messages: Cytoplasm
messages: Nucleus
messages: Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing.

284811:AGOS ACL077C
gene id: 284811:AGOS_ACL077C
uniprot id: Q75CJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Cytoplasm

284811:AGOS AFR725C
gene id: 284811:AGOS_AFR725C
uniprot id: Q751V0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GTPase-activating protein for the ADP ribosylation factor family.

284811:AGOS ACL039W
gene id: 284811:AGOS_ACL039W
uniprot id: Q75CF8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

284811:AGOS ABL020W
gene id: 284811:AGOS_ABL020W
uniprot id: Q75DN7
names: Similarity
messages: Belongs to the MUB1/samB family.

284811:AGOS AEL225C
gene id: 284811:AGOS_AEL225C
uniprot id: Q758I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.

284811:AGOS AGR300W
gene id: 284811:AGOS_AGR300W
uniprot id: Q74ZA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: cis-Golgi network

284811:AGOS ADR210C
gene id: 284811:AGOS_ADR210C
uniprot id: Q759R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity).
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane

284811:AGOS AER307W
gene id: 284811:AGOS_AER307W
uniprot id: Q756F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Membrane
messages: Nucleus membrane
messages: nuclear pore complex

284811:AGOS AEL169W
gene id: 284811:AGOS_AEL169W
uniprot id: Q758C1
names: Similarity
messages: Belongs to the SDHAF4 family.

284811:AGOS AEL182W
gene id: 284811:AGOS_AEL182W
uniprot id: Q758E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome subunit S5B/HSM3 family.
messages: Cytoplasm
messages: Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC) (By similarity).

284811:AGOS AFL107W
gene id: 284811:AGOS_AFL107W
uniprot id: Q755D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic GTase family.
messages: Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.
messages: Nucleus
messages: Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.

284811:AGOS AAL082W
gene id: 284811:AGOS_AAL082W
uniprot id: Q75F10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS AFR289W
gene id: 284811:AGOS_AFR289W
uniprot id: Q753M3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTAG/PCC1 family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. PCC1 functions as a dimerization module for the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators (By similarity).
messages: Nucleus
messages: telomere

284811:AGOS ABL030W
gene id: 284811:AGOS_ABL030W
uniprot id: Q75DP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: telomere

284811:AGOS AFR599W
gene id: 284811:AGOS_AFR599W
uniprot id: Q752H4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint (By similarity).

284811:AGOS AER147W
gene id: 284811:AGOS_AER147W
uniprot id: Q756V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG8 family.
messages: Membrane

284811:AGOS AGL256W
gene id: 284811:AGOS_AGL256W
uniprot id: Q751G2
names: Function
names: Similarity
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

284811:AGOS ABL153W
gene id: 284811:AGOS_ABL153W
uniprot id: Q75E23
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AER340W
gene id: 284811:AGOS_AER340W
uniprot id: Q756C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the misato family.
messages: Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.
messages: Mitochondrion

284811:AGOS ACR271C
gene id: 284811:AGOS_ACR271C
uniprot id: Q75BK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTU2/NCS2 family.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.

284811:AGOS AFL158C
gene id: 284811:AGOS_AFL158C
uniprot id: Q755I1
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADR271W
gene id: 284811:AGOS_ADR271W
uniprot id: Q759K6
names: Similarity
messages: Belongs to the Luc7 family.

284811:AGOS AFL057W
gene id: 284811:AGOS_AFL057W
uniprot id: Q754X3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

284811:AGOS AER091W
gene id: 284811:AGOS_AER091W
uniprot id: Q757C2
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AGR088W
gene id: 284811:AGOS_AGR088W
uniprot id: Q74ZX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSF1 family.
messages: Membrane
messages: Required for the glucose and other nutrients uptake at low temperature.

284811:AGOS AGL126C
gene id: 284811:AGOS_AGL126C
uniprot id: Q751A6
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

284811:AGOS ADL009W
gene id: 284811:AGOS_ADL009W
uniprot id: Q75AC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS AFL079W
gene id: 284811:AGOS_AFL079W
uniprot id: Q755A4
names: Function
messages: Delta(8)-fatty-acid desaturase which introduces a double bond at the 8-position in the long-chain base (LCB) of ceramides. Required for the formation of the di-unsaturated sphingoid base (E,E)-sphinga-4,8-dienine during glucosylceramide (GluCer) biosynthesis.

284811:AGOS ACL065C
gene id: 284811:AGOS_ACL065C
uniprot id: Q75CI4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

284811:AGOS AFR329C
gene id: 284811:AGOS_AFR329C
uniprot id: Q753I3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DGK1 family.
messages: CTP-dependent diacylglycerol kinase that catalyzes the phosphorylation of diacylglycerol (DAG) to phosphatidate (PA). Controls phosphatidate levels at the nuclear envelope. May be involved in vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus.
messages: Endoplasmic reticulum membrane
messages: Nucleus membrane

284811:AGOS AFR287W
gene id: 284811:AGOS_AFR287W
uniprot id: Q753M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM10 family.
messages: Nucleus

284811:AGOS AGL131W
gene id: 284811:AGOS_AGL131W
uniprot id: Q750S0
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ACR284C
gene id: 284811:AGOS_ACR284C
uniprot id: Q75BI7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

284811:AGOS ABR161C
gene id: 284811:AGOS_ABR161C
uniprot id: Q75D62
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

284811:AGOS AFR254C
gene id: 284811:AGOS_AFR254C
uniprot id: Q753S2
names: Function
names: Similarity
messages: Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.
messages: In the C-terminal section; belongs to the AIR synthase family.
messages: In the N-terminal section; belongs to the GARS family.

284811:AGOS AFR343C
gene id: 284811:AGOS_AFR343C
uniprot id: Q753G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

284811:AGOS ABR196C
gene id: 284811:AGOS_ABR196C
uniprot id: Q75D26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Part of a complex that contains SEC61, SEC62, SEC63, SEC66 and SEC72.
messages: Required for preprotein translocation.

284811:AGOS AGR002W
gene id: 284811:AGOS_AGR002W
uniprot id: Q750F3
names: Similarity
messages: Belongs to the citrate synthase family.

284811:AGOS ACR145W
gene id: 284811:AGOS_ACR145W
uniprot id: Q8J1G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Required for assembly of the mitotic spindle.
messages: cytoskeleton

284811:AGOS ACR142W
gene id: 284811:AGOS_ACR142W
uniprot id: Q75CE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.
messages: Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5.
messages: Nucleus

284811:AGOS AGR102C
gene id: 284811:AGOS_AGR102C
uniprot id: Q74ZU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family.
messages: Component of the nucleoplasmic and cytoplasmic pre-60S ribosomal particles.
messages: Cytoplasm
messages: Nucleus
messages: Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).

284811:AGOS AEL307C
gene id: 284811:AGOS_AEL307C
uniprot id: Q758R0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHE2 family.
messages: Cytoplasm
messages: Homodimer and homotetramer.
messages: Nucleus
messages: RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell (By similarity).

284811:AGOS AFR545W
gene id: 284811:AGOS_AFR545W
uniprot id: Q752M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKN1/KRE6 family.
messages: Membrane

284811:AGOS AER143W
gene id: 284811:AGOS_AER143W
uniprot id: Q756V8
names: Similarity
messages: Belongs to the hexokinase family.

284811:AGOS AAR131W
gene id: 284811:AGOS_AAR131W
uniprot id: Q75EF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the crooked-neck family.
messages: Involved in pre-mRNA splicing and cell cycle progression.
messages: Nucleus

284811:AGOS ACR216C
gene id: 284811:AGOS_ACR216C
uniprot id: Q75BQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

284811:AGOS AGR071C
gene id: 284811:AGOS_AGR071C
uniprot id: Q74ZY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

284811:AGOS ACL184C
gene id: 284811:AGOS_ACL184C
uniprot id: Q75CV0
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

284811:AGOS ADR239W
gene id: 284811:AGOS_ADR239W
uniprot id: Q759N6
names: Similarity
messages: Belongs to the multicopper oxidase family.

284811:AGOS AGL287W
gene id: 284811:AGOS_AGL287W
uniprot id: Q751J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with DNA double-strand breaks.
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).
messages: telomere

284811:AGOS AFL037W
gene id: 284811:AGOS_AFL037W
uniprot id: Q754Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AGL039W
gene id: 284811:AGOS_AGL039W
uniprot id: Q750J0
names: Function
names: Similarity
messages: Belongs to the NPR3 family.
messages: Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division (By similarity).

284811:AGOS ACR084C
gene id: 284811:AGOS_ACR084C
uniprot id: Q75C33
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

284811:AGOS AFR720W
gene id: 284811:AGOS_AFR720W
uniprot id: Q751V5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS ADR083W
gene id: 284811:AGOS_ADR083W
uniprot id: Q75A36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

284811:AGOS AGL200W
gene id: 284811:AGOS_AGL200W
uniprot id: Q751B0
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

284811:AGOS AER206C
gene id: 284811:AGOS_AER206C
uniprot id: Q756P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus
messages: Required for pre-mRNA splicing.

284811:AGOS AEL195W
gene id: 284811:AGOS_AEL195W
uniprot id: Q758F7
names: Similarity
messages: Belongs to the cyclin family.

284811:AGOS AFR218W
gene id: 284811:AGOS_AFR218W
uniprot id: Q754H6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NCBP1 family.
messages: Component of the cap-binding complex (CBC) involved in the nuclear export of capped U snRNAs. The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation; and involved in rRNA processing at sites A0, A1 and A2 (By similarity).
messages: Component of the nuclear cap-binding complex (CBC).
messages: Nucleus

284811:AGOS AFL112W
gene id: 284811:AGOS_AFL112W
uniprot id: Q755D5
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ADL235W
gene id: 284811:AGOS_ADL235W
uniprot id: Q75B12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum (By similarity).

284811:AGOS ACR218W
gene id: 284811:AGOS_ACR218W
uniprot id: Q75BQ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

284811:AGOS ADL384W
gene id: 284811:AGOS_ADL384W
uniprot id: Q75BE8
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

284811:AGOS ACR088W
gene id: 284811:AGOS_ACR088W
uniprot id: Q75C29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

284811:AGOS ACR188C
gene id: 284811:AGOS_ACR188C
uniprot id: Q75BT3
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

284811:AGOS ADR120C
gene id: 284811:AGOS_ADR120C
uniprot id: Q75A07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family.
messages: Mitochondrion
messages: N-acetylglutamate synthase involved in arginine biosynthesis.

284811:AGOS AGR344W
gene id: 284811:AGOS_AGR344W
uniprot id: Q74Z62
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

284811:AGOS ABR119C
gene id: 284811:AGOS_ABR119C
uniprot id: Q75DA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

284811:AGOS AFR552C
gene id: 284811:AGOS_AFR552C
uniprot id: Q752M2
names: Similarity
messages: Belongs to the phosducin family.

284811:AGOS ABL066C
gene id: 284811:AGOS_ABL066C
uniprot id: Q75DT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM31/MDM32 family.
messages: Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS AGL203C
gene id: 284811:AGOS_AGL203C
uniprot id: Q750Z0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

284811:AGOS AFR249W
gene id: 284811:AGOS_AFR249W
uniprot id: Q753S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AER268W
gene id: 284811:AGOS_AER268W
uniprot id: Q756W6
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

284811:AGOS AFR099C
gene id: 284811:AGOS_AFR099C
uniprot id: Q754H3
names: Similarity
messages: Belongs to the TRL1 family.

284811:AGOS AGL211C
gene id: 284811:AGOS_AGL211C
uniprot id: Q751B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

284811:AGOS ABL159W
gene id: 284811:AGOS_ABL159W
uniprot id: Q75E29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

284811:AGOS AFR004W
gene id: 284811:AGOS_AFR004W
uniprot id: Q754R8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF5 family.
messages: Nucleus
messages: Part of the chromatin structure-remodeling complex (RSC) which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and required for cell cycle progression (By similarity).

284811:AGOS AFR692C
gene id: 284811:AGOS_AFR692C
uniprot id: Q751Y3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

284811:AGOS AGR083W
gene id: 284811:AGOS_AGR083W
uniprot id: Q74ZX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

284811:AGOS AAR139W
gene id: 284811:AGOS_AAR139W
uniprot id: Q75EE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.
messages: nucleolus

284811:AGOS ABR164W
gene id: 284811:AGOS_ABR164W
uniprot id: Q75D59
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

284811:AGOS ABR129C
gene id: 284811:AGOS_ABR129C
uniprot id: Q75D95
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AEL340W
gene id: 284811:AGOS_AEL340W
uniprot id: Q758U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIL1 family.
messages: Endoplasmic reticulum lumen
messages: Interacts with KAR2.
messages: Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 (By similarity).

284811:AGOS ABL065W
gene id: 284811:AGOS_ABL065W
uniprot id: Q75DT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

284811:AGOS ABR212C
gene id: 284811:AGOS_ABR212C
uniprot id: Q75D10
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

284811:AGOS AFR561W
gene id: 284811:AGOS_AFR561W
uniprot id: Q752L3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

284811:AGOS AGL054W
gene id: 284811:AGOS_AGL054W
uniprot id: Q750K5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

284811:AGOS ADR320C
gene id: 284811:AGOS_ADR320C
uniprot id: Q759F6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
messages: Interacts with histone H3 and histone H4.
messages: Nucleus

284811:AGOS AEL123W
gene id: 284811:AGOS_AEL123W
uniprot id: Q757Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: nucleolus

284811:AGOS AGR196W
gene id: 284811:AGOS_AGR196W
uniprot id: Q74ZK4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Maintains high levels of reduced glutathione in the cytosol.
messages: The active site is a redox-active disulfide bond.

284811:AGOS AFL038C
gene id: 284811:AGOS_AFL038C
uniprot id: Q754Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Membrane
messages: nuclear pore complex

284811:AGOS AEL132W
gene id: 284811:AGOS_AEL132W
uniprot id: Q757Z2
names: Similarity
messages: Belongs to the peptidase M20A family.

284811:AGOS AGR264C
gene id: 284811:AGOS_AGR264C
uniprot id: Q74ZD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
messages: Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization.
messages: Endoplasmic reticulum membrane

284811:AGOS AGL002C
gene id: 284811:AGOS_AGL002C
uniprot id: Q750F6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

284811:AGOS AGL022W
gene id: 284811:AGOS_AGL022W
uniprot id: Q750L4
names: Similarity
messages: Belongs to the BLM10 family.

284811:AGOS AFL025C
gene id: 284811:AGOS_AFL025C
uniprot id: Q754U6
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR622W
gene id: 284811:AGOS_AFR622W
uniprot id: Q752F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

284811:AGOS AFR003C
gene id: 284811:AGOS_AFR003C
uniprot id: Q754R9
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

284811:AGOS AER441C
gene id: 284811:AGOS_AER441C
uniprot id: Q755S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

284811:AGOS ADL163W
gene id: 284811:AGOS_ADL163W
uniprot id: Q75AT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase TRM13 family.
messages: Cytoplasm
messages: nucleolus
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

284811:AGOS ADL341C
gene id: 284811:AGOS_ADL341C
uniprot id: Q75BA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS AER293C
gene id: 284811:AGOS_AER293C
uniprot id: Q756H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

284811:AGOS ADR138C
gene id: 284811:AGOS_ADR138C
uniprot id: Q759Y5
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
messages: Heterodimer of an alpha and a beta chain.
messages: Mitochondrion matrix
messages: The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

284811:AGOS ABR079C
gene id: 284811:AGOS_ABR079C
uniprot id: Q75DE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex ASK1 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
messages: Nucleus
messages: The DASH complex oligomerizes to form rings that encircle the microtubules.
messages: kinetochore
messages: spindle

284811:AGOS ACL132C
gene id: 284811:AGOS_ACL132C
uniprot id: Q75CQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLASP family.
messages: Belongs to the TOG/XMAP215 family.
messages: spindle

284811:AGOS ADR226C
gene id: 284811:AGOS_ADR226C
uniprot id: Q759P7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking and spindle migration.
messages: The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.

284811:AGOS AGR149W
gene id: 284811:AGOS_AGR149W
uniprot id: Q74ZP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Required for vacuolar assembly and vacuolar traffic.
messages: Vacuole

284811:AGOS ACR220C
gene id: 284811:AGOS_ACR220C
uniprot id: Q75BQ1
names: Similarity
messages: Belongs to the TMCO4 family.

284811:AGOS ADL102C
gene id: 284811:AGOS_ADL102C
uniprot id: Q75AM5
names: Similarity
messages: Belongs to the protein kinase superfamily.

284811:AGOS ADL126C
gene id: 284811:AGOS_ADL126C
uniprot id: Q75AP6
names: Function
names: Similarity
messages: Belongs to the RRT5 family.
messages: May be involved in the modulation of rDNA transcription.

284811:AGOS AFL078W
gene id: 284811:AGOS_AFL078W
uniprot id: Q755A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXR1 family.
messages: May be involved in protection from oxidative damage.
messages: Mitochondrion

284811:AGOS ACR008W
gene id: 284811:AGOS_ACR008W
uniprot id: Q75CA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining.
messages: Nucleus

284811:AGOS ACR241C
gene id: 284811:AGOS_ACR241C
uniprot id: Q75BN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OAF3 family.
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus
messages: Transcriptional inhibitor with a significantly increased number of target genes in response to oleate.

284811:AGOS ADL378W
gene id: 284811:AGOS_ADL378W
uniprot id: Q75BE2
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

284811:AGOS ADL372W
gene id: 284811:AGOS_ADL372W
uniprot id: Q75BH5
names: Subcellular Location Annotation
messages: Mitochondrion

284811:AGOS ABL192C
gene id: 284811:AGOS_ABL192C
uniprot id: Q75E62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SQS1 family.
messages: Cytoplasm
messages: May be involved in splicing.
messages: Nucleus

284811:AGOS ADR073W
gene id: 284811:AGOS_ADR073W
uniprot id: Q75A46
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

284811:AGOS AFR071W
gene id: 284811:AGOS_AFR071W
uniprot id: Q754K1
names: Similarity
messages: Belongs to the phospholipase D family.

284811:AGOS ABR047W
gene id: 284811:AGOS_ABR047W
uniprot id: Q75DH8
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

284811:AGOS ADL393W
gene id: 284811:AGOS_ADL393W
uniprot id: Q755R3
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ABL150W
gene id: 284811:AGOS_ABL150W
uniprot id: Q75E20
names: Similarity
messages: Belongs to the importin alpha family.

284811:AGOS AAR046C
gene id: 284811:AGOS_AAR046C
uniprot id: Q75EN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).
messages: Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity).
messages: Prevacuolar compartment membrane
messages: multivesicular body membrane

284811:AGOS AGL343C
gene id: 284811:AGOS_AGL343C
uniprot id: Q751R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

284811:AGOS AFR086C
gene id: 284811:AGOS_AFR086C
uniprot id: Q754I8
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

284811:AGOS ADL296C
gene id: 284811:AGOS_ADL296C
uniprot id: Q75B68
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.

284811:AGOS AGR038C
gene id: 284811:AGOS_AGR038C
uniprot id: Q750B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

284811:AGOS AEL002W
gene id: 284811:AGOS_AEL002W
uniprot id: Q8J1F8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of N-terminal lysines and particularly formation of H2BK11ac has a positive effect on transcription.
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitinated by the UBC2-BRE1 complex to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and H3K79me formation. H2BK123ub1 also modulates the formation of double-strand breaks during meiosis and is a prerequisite for DNA-damage checkpoint activation (By similarity).
messages: Nucleus
messages: Phosphorylated by STE20 to form H2BS10ph during progression through meiotic prophase. May be correlated with chromosome condensation (By similarity).
messages: Sumoylation to form H2BK6su or H2BK7su occurs preferentially near the telomeres and represses gene transcription.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2BK6ac = acetylated Lys-7; H2BK6su = sumoylated Lys-7; H2BK7ac = acetylated Lys-8; H2BK7su = sumoylated Lys-8; H2BS10ph = phosphorylated Ser-11; H2BK11ac = acetylated Lys-12; H2BK123ub1 = monoubiquitinated Lys-120.

284811:AGOS AGL350C
gene id: 284811:AGOS_AGL350C
uniprot id: Q751P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PINX1 family.
messages: Involved in rRNA-processing at A0, A1 and A2 sites and regulates negatively telomerase.
messages: nucleolus

284811:AGOS AFR571W
gene id: 284811:AGOS_AFR571W
uniprot id: Q752K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

284811:AGOS ADL307W
gene id: 284811:AGOS_ADL307W
uniprot id: Q75B79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG11 family.
messages: Homodimer.
messages: Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion (By similarity).
messages: Preautophagosomal structure membrane
messages: Vacuole membrane

284811:AGOS AFR020W
gene id: 284811:AGOS_AFR020W
uniprot id: Q754Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyl-CoA hydrolase/transferase family.
messages: Cytoplasm
messages: Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.

284811:AGOS ADR419C
gene id: 284811:AGOS_ADR419C
uniprot id: Q758V9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

284811:AGOS ADR306W
gene id: 284811:AGOS_ADR306W
uniprot id: Q759I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPI1/TEX10 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
messages: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.
messages: Nucleus

284811:AGOS AFL134W
gene id: 284811:AGOS_AFL134W
uniprot id: Q755F7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fungal TPase family.
messages: First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.
messages: Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.
messages: Nucleus

284811:AGOS AAL049C
gene id: 284811:AGOS_AAL049C
uniprot id: Q75EX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS AER048C
gene id: 284811:AGOS_AER048C
uniprot id: Q757G5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWC7 family.
messages: Component of the SWR1 chromatin remodeling complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
messages: Nucleus

284811:AGOS AER046W
gene id: 284811:AGOS_AER046W
uniprot id: Q757G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAD52 family.
messages: Interacts with RAD51 and RAD52.
messages: Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA (By similarity).
messages: Nucleus

284811:AGOS ADR003C
gene id: 284811:AGOS_ADR003C
uniprot id: Q75AB5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

284811:AGOS ABL138W
gene id: 284811:AGOS_ABL138W
uniprot id: Q75E11
names: Similarity
messages: Belongs to the universal ribosomal protein uS3 family.

284811:AGOS AGL100W
gene id: 284811:AGOS_AGL100W
uniprot id: Q751B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EST1 family.
messages: Involved in telomere maintenance.
messages: Nucleus
messages: telomere

284811:AGOS AEL207W
gene id: 284811:AGOS_AEL207W
uniprot id: Q9HFW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Catalytic subunit of the TRAMP5 complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Polyadenylates RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. TRF5 is also required for proper nuclear division in mitosis and sister chromatid cohesion. Involved in the regulation of histone mRNA levels. May mediate mitotic chromosome condensation (By similarity).
messages: nucleolus

284811:AGOS ACL047W
gene id: 284811:AGOS_ACL047W
uniprot id: Q75CG6
names: Similarity
messages: Belongs to the SEC6 family.

284811:AGOS ABL085W
gene id: 284811:AGOS_ABL085W
uniprot id: Q75DV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

284811:AGOS AAR077C
gene id: 284811:AGOS_AAR077C
uniprot id: Q75EK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.
messages: Cytoplasm
messages: Monomer.

284811:AGOS ABL021C
gene id: 284811:AGOS_ABL021C
uniprot id: Q75DN8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS ABR188W
gene id: 284811:AGOS_ABR188W
uniprot id: Q75D35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

284811:AGOS AFR053C
gene id: 284811:AGOS_AFR053C
uniprot id: Q754L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

284811:AGOS AGR211W
gene id: 284811:AGOS_AGR211W
uniprot id: Q74ZJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPL4 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity).
messages: Nucleus membrane
messages: perinuclear region

284811:AGOS ABR091C
gene id: 284811:AGOS_ABR091C
uniprot id: Q75DD6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCS1 family.
messages: Binds 2 copper ions per subunit.
messages: Copper chaperone for superoxide dismutase 1 (SOD1). Binds copper ions and delivers them specifically to SOD1 (By similarity).
messages: Cytoplasm

284811:AGOS AEL167C
gene id: 284811:AGOS_AEL167C
uniprot id: Q758B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

284811:AGOS AAR161W
gene id: 284811:AGOS_AAR161W
uniprot id: Q75ED7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex DUO1 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
messages: Nucleus
messages: The DASH complex oligomerizes to form rings that encircle the microtubules.
messages: kinetochore
messages: spindle

284811:AGOS AGL221W
gene id: 284811:AGOS_AGL221W
uniprot id: Q751C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Component of the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

284811:AGOS AER056C
gene id: 284811:AGOS_AER056C
uniprot id: Q757F7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

284811:AGOS AER298C
gene id: 284811:AGOS_AER298C
uniprot id: Q756G8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).
messages: Homodimer.
messages: Preautophagosomal structure
messages: The GxGxxG motif is important for the function, possibly through binding with ATP.

284811:AGOS AGR015C
gene id: 284811:AGOS_AGR015C
uniprot id: Q750E0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Binds 1 zinc ion per monomer.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
messages: Homooctamer.

284811:AGOS ACL196W
gene id: 284811:AGOS_ACL196W
uniprot id: Q75CW2
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

284811:AGOS ABL112W
gene id: 284811:AGOS_ABL112W
uniprot id: Q75DY5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

284811:AGOS ADR275W
gene id: 284811:AGOS_ADR275W
uniprot id: Q759K2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
messages: Heterodimer of an alpha and a beta subunit.

284811:AGOS ADR230W
gene id: 284811:AGOS_ADR230W
uniprot id: Q75A03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DIA2 family.
messages: F-box protein component of a SCF ubiquitin ligase complex involved in ubiquitin-dependent protein degradation. The SCF-DIA2 complex is specifically involved in the pheromone induced degradation of phosphorylated TEC1. Involved in DNA replication, genome stability, and the control of cell cycle, probably through its association to replication origins to facilitate the ubiquitination of another origin-binding protein (By similarity).
messages: Forms a SCF ubiquitin ligase complex which binds to DNA replication origins.
messages: Nucleus

284811:AGOS AEL014C
gene id: 284811:AGOS_AEL014C
uniprot id: Q757M2
names: Similarity
messages: Belongs to the SF3A2 family.

284811:AGOS AGL052W
gene id: 284811:AGOS_AGL052W
uniprot id: Q750K3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.
messages: Vacuole membrane

284811:AGOS AGL281C
gene id: 284811:AGOS_AGL281C
uniprot id: Q751I7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

284811:AGOS ADL017C
gene id: 284811:AGOS_ADL017C
uniprot id: Q75AD4
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

284811:AGOS ADR096C
gene id: 284811:AGOS_ADR096C
uniprot id: Q75A24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

284811:AGOS AFR337W
gene id: 284811:AGOS_AFR337W
uniprot id: Q753H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels.
messages: Belongs to the ADIPOR family.
messages: Endoplasmic reticulum membrane

284811:AGOS AFR639W
gene id: 284811:AGOS_AFR639W
uniprot id: Q752D7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DPH4 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
messages: The DPH-type metal-binding (MB) domain can bind either zinc or iron ions.

284811:AGOS AAL157C
gene id: 284811:AGOS_AAL157C
uniprot id: Q75F99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

284811:AGOS ADL100W
gene id: 284811:AGOS_ADL100W
uniprot id: Q75AM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AFR562C
gene id: 284811:AGOS_AFR562C
uniprot id: Q752L2
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ACR065C
gene id: 284811:AGOS_ACR065C
uniprot id: Q75C52
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

284811:AGOS AER229C
gene id: 284811:AGOS_AER229C
uniprot id: Q756M5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

284811:AGOS ACR011C
gene id: 284811:AGOS_ACR011C
uniprot id: Q75CA1
names: Subcellular Location Annotation
messages: nucleolus

284811:AGOS AFR370C
gene id: 284811:AGOS_AFR370C
uniprot id: Q753E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: coated pit

284811:AGOS ABR080W
gene id: 284811:AGOS_ABR080W
uniprot id: Q75DE7
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ABR096C
gene id: 284811:AGOS_ABR096C
uniprot id: Q75DD1
names: Function
names: Similarity
messages: Belongs to the NDK family.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).

284811:AGOS AFL156W
gene id: 284811:AGOS_AFL156W
uniprot id: Q755H9
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

284811:AGOS ABR183W
gene id: 284811:AGOS_ABR183W
uniprot id: Q9HF54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Involved in the regulation of actin polarization. Rho proteins are required for distinct steps during polarized hyphal growth of A.gossypii.

284811:AGOS ACR032C
gene id: 284811:AGOS_ACR032C
uniprot id: Q75C84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
messages: nucleolus

284811:AGOS ABR135C
gene id: 284811:AGOS_ABR135C
uniprot id: Q75D89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

284811:AGOS AGR287C
gene id: 284811:AGOS_AGR287C
uniprot id: Q74ZB2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS30 family.

284811:AGOS AAR083C
gene id: 284811:AGOS_AAR083C
uniprot id: Q75EJ6
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

284811:AGOS ADL387C
gene id: 284811:AGOS_ADL387C
uniprot id: Q75BF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET5 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Putative protein lysine methyltransferase.

284811:AGOS ACL140C
gene id: 284811:AGOS_ACL140C
uniprot id: Q75CQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.
messages: Cytoplasm
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.

284811:AGOS ADL399C
gene id: 284811:AGOS_ADL399C
uniprot id: Q75BG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

284811:AGOS AFR059W
gene id: 284811:AGOS_AFR059W
uniprot id: Q754L3
names: Similarity
messages: Belongs to the SF3B5 family.

284811:AGOS AFR404C
gene id: 284811:AGOS_AFR404C
uniprot id: Q753Q4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).
messages: Nucleus
messages: The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits (By similarity).

284811:AGOS AGL018C
gene id: 284811:AGOS_AGL018C
uniprot id: Q750H1
names: Cofactor
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.

284811:AGOS AFR082C
gene id: 284811:AGOS_AFR082C
uniprot id: Q754J2
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.
messages: Present with 1460 molecules/cell in log phase SD medium.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

284811:AGOS ADR402W
gene id: 284811:AGOS_ADR402W
uniprot id: Q758X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.
messages: Mitochondrion outer membrane

284811:AGOS AGR382W
gene id: 284811:AGOS_AGR382W
uniprot id: Q74Z24
names: Function
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Catalyzes the transfer of a 4'-phosphopantetheine moiety from coenzyme A to a serine residue of acceptor proteins, such as alpha-aminoadipate reductase. Necessary for alpha-aminoadipate reductase activity (By similarity).

284811:AGOS ADL061W
gene id: 284811:AGOS_ADL061W
uniprot id: Q75AI8
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

284811:AGOS ADR177C
gene id: 284811:AGOS_ADR177C
uniprot id: Q759U6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

284811:AGOS AFR061W
gene id: 284811:AGOS_AFR061W
uniprot id: Q754L1
names: Similarity
messages: Belongs to the CAP family.

284811:AGOS ADL353C
gene id: 284811:AGOS_ADL353C
uniprot id: Q75BC0
names: Subcellular Location Annotation
messages: nucleolus

284811:AGOS AER168C
gene id: 284811:AGOS_AER168C
uniprot id: Q756T5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1 (By similarity).

284811:AGOS AGR200W
gene id: 284811:AGOS_AGR200W
uniprot id: Q74ZK0
names: Similarity
messages: Belongs to the threonine aldolase family.

284811:AGOS AFR431C
gene id: 284811:AGOS_AFR431C
uniprot id: Q752Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

284811:AGOS ACL018W
gene id: 284811:AGOS_ACL018W
uniprot id: Q75CC7
names: Similarity
messages: Belongs to the OPA3 family.

284811:AGOS ACR089C
gene id: 284811:AGOS_ACR089C
uniprot id: Q75C28
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

284811:AGOS AER001C
gene id: 284811:AGOS_AER001C
uniprot id: Q757L1
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

284811:AGOS AEL272W
gene id: 284811:AGOS_AEL272W
uniprot id: Q758M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1.

284811:AGOS AEL339C
gene id: 284811:AGOS_AEL339C
uniprot id: Q758U1
names: Similarity
messages: Belongs to the OPI10 family.

284811:AGOS AGR249C
gene id: 284811:AGOS_AGR249C
uniprot id: Q74ZF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dUTPase family.
messages: Homotrimer.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

284811:AGOS ABR194C
gene id: 284811:AGOS_ABR194C
uniprot id: Q75D28
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

284811:AGOS AER125C
gene id: 284811:AGOS_AER125C
uniprot id: Q756Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

284811:AGOS AER264C
gene id: 284811:AGOS_AER264C
uniprot id: Q756W3
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

284811:AGOS AGL306C
gene id: 284811:AGOS_AGL306C
uniprot id: Q751K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD4 family.
messages: Cell septum
messages: May be involved in the septin organization at the site of septation.

284811:AGOS AFL147C
gene id: 284811:AGOS_AFL147C
uniprot id: Q755H0
names: Similarity
messages: Belongs to the Tango6 family.

284811:AGOS ADR360W
gene id: 284811:AGOS_ADR360W
uniprot id: Q759B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GIP4 family.
messages: Cytoplasm
messages: GLC7 phosphatase-regulatory protein involved in GLC7 subcellular redistribution and chromosome segregation.
messages: Interacts with GLC7.

284811:AGOS AGL263W
gene id: 284811:AGOS_AGL263W
uniprot id: Q751G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the NTC complex (or PRP19-associated complex). The NTC complex associates with the spliceosome after the release of the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex reminiscent of a late-stage spliceosome.
messages: Belongs to the CWC21 family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity).
messages: Nucleus

284811:AGOS AEL244W
gene id: 284811:AGOS_AEL244W
uniprot id: Q758K6
names: Similarity
messages: Belongs to the AAA ATPase family.

284811:AGOS AAR038W
gene id: 284811:AGOS_AAR038W
uniprot id: Q75EP1
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR333W
gene id: 284811:AGOS_AFR333W
uniprot id: Q753H9
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AAL147C
gene id: 284811:AGOS_AAL147C
uniprot id: Q75F75
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

284811:AGOS AER244C
gene id: 284811:AGOS_AER244C
uniprot id: Q756L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF1 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

284811:AGOS AAR025C
gene id: 284811:AGOS_AAR025C
uniprot id: Q75EQ4
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

284811:AGOS ADL128C
gene id: 284811:AGOS_ADL128C
uniprot id: Q75AP8
names: Similarity
messages: Belongs to the exportin family.

284811:AGOS ADL270C
gene id: 284811:AGOS_ADL270C
uniprot id: Q75B47
names: Similarity
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.

284811:AGOS ACR262C
gene id: 284811:AGOS_ACR262C
uniprot id: Q75BK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM23 family.
messages: Mitochondrion

284811:AGOS ADR013W
gene id: 284811:AGOS_ADR013W
uniprot id: Q75AA5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import (By similarity).

284811:AGOS AFR103W
gene id: 284811:AGOS_AFR103W
uniprot id: Q754G7
names: Function
names: Similarity
messages: Belongs to the IRS4 family.
messages: Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).

284811:AGOS AFL051W
gene id: 284811:AGOS_AFL051W
uniprot id: Q754W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-Z subfamily.
messages: Cytoplasm

284811:AGOS ACR071W
gene id: 284811:AGOS_ACR071W
uniprot id: Q75C46
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.

284811:AGOS AFL206C
gene id: 284811:AGOS_AFL206C
uniprot id: Q755M0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

284811:AGOS AFR167W
gene id: 284811:AGOS_AFR167W
uniprot id: Q754A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

284811:AGOS AGL220W
gene id: 284811:AGOS_AGL220W
uniprot id: Q751C6
names: Similarity
messages: Belongs to the PAT1 family.

284811:AGOS AAL167W
gene id: 284811:AGOS_AAL167W
uniprot id: Q75FA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

284811:AGOS AAR043C
gene id: 284811:AGOS_AAR043C
uniprot id: Q75EN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS ABR236W
gene id: 284811:AGOS_ABR236W
uniprot id: Q75CY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

284811:AGOS AER007W
gene id: 284811:AGOS_AER007W
uniprot id: Q757K5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

284811:AGOS AAR162C
gene id: 284811:AGOS_AAR162C
uniprot id: Q75ED6
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
messages: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

284811:AGOS AFR433C
gene id: 284811:AGOS_AFR433C
uniprot id: Q752Y8
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

284811:AGOS AFR499C
gene id: 284811:AGOS_AFR499C
uniprot id: Q752S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC24 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

284811:AGOS ADL370C
gene id: 284811:AGOS_ADL370C
uniprot id: P41752
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

284811:AGOS AGR025W
gene id: 284811:AGOS_AGR025W
uniprot id: Q750D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Membrane

284811:AGOS AGL122W
gene id: 284811:AGOS_AGL122W
uniprot id: Q750R4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

284811:AGOS AAR121W
gene id: 284811:AGOS_AAR121W
uniprot id: Q75EG0
names: Similarity
messages: Belongs to the PIAS family.

284811:AGOS AGL094W
gene id: 284811:AGOS_AGL094W
uniprot id: Q750P2
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

284811:AGOS AFL128C
gene id: 284811:AGOS_AFL128C
uniprot id: Q755F1
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADR327W
gene id: 284811:AGOS_ADR327W
uniprot id: Q759F0
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

284811:AGOS AER412W
gene id: 284811:AGOS_AER412W
uniprot id: Q755V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPIN family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex involved in endosomal cargo sorting.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1).
messages: Endosome

284811:AGOS ACR181C
gene id: 284811:AGOS_ACR181C
uniprot id: Q75BU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

284811:AGOS ABR104W
gene id: 284811:AGOS_ABR104W
uniprot id: Q75DC2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Required for tolerance to alcohol.

284811:AGOS ABR123W
gene id: 284811:AGOS_ABR123W
uniprot id: Q75DA1
names: Similarity
messages: Belongs to the glutaminase PdxT/SNO family.

284811:AGOS ACR177W
gene id: 284811:AGOS_ACR177W
uniprot id: Q75BU4
names: Similarity
messages: Belongs to the TMEM14 family.

284811:AGOS ABR152C
gene id: 284811:AGOS_ABR152C
uniprot id: Q75D71
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

284811:AGOS AFR647C
gene id: 284811:AGOS_AFR647C
uniprot id: Q752C8
names: Function
names: Similarity
messages: Catalyzes three sequential steps of tetrahydrofolate biosynthesis.
messages: In the C-terminal section; belongs to the DHPS family.
messages: In the N-terminal section; belongs to the DHNA family.
messages: In the central section; belongs to the HPPK family.

284811:AGOS AAR016W
gene id: 284811:AGOS_AAR016W
uniprot id: Q75ER3
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ACR251C
gene id: 284811:AGOS_ACR251C
uniprot id: Q75BM0
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

284811:AGOS ABR024C
gene id: 284811:AGOS_ABR024C
uniprot id: Q75DJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role (via N-terminus) in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. Further stabilizes spliceosome conformation for 3'-splice site docking (via C-terminus) promoting exon ligation.

284811:AGOS AGL210C
gene id: 284811:AGOS_AGL210C
uniprot id: Q750Z7
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

284811:AGOS AEL251C
gene id: 284811:AGOS_AEL251C
uniprot id: Q758L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase subunit B family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).
messages: Mitochondrion
messages: Mitochondrion inner membrane

284811:AGOS AER350W
gene id: 284811:AGOS_AER350W
uniprot id: Q756B7
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.

284811:AGOS AFR494W
gene id: 284811:AGOS_AFR494W
uniprot id: Q752S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Nucleus
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
messages: telomere

284811:AGOS ACL033C
gene id: 284811:AGOS_ACL033C
uniprot id: Q75CF3
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S1 family.

284811:AGOS AEL142W
gene id: 284811:AGOS_AEL142W
uniprot id: Q758A2
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.

284811:AGOS AFL229W
gene id: 284811:AGOS_AFL229W
uniprot id: Q755P2
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.

284811:AGOS ADR123W
gene id: 284811:AGOS_ADR123W
uniprot id: Q75A00
names: Similarity
messages: Belongs to the peptidase M28 family.

284811:AGOS ACL135W
gene id: 284811:AGOS_ACL135W
uniprot id: Q75CQ4
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFL059C
gene id: 284811:AGOS_AFL059C
uniprot id: Q754X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

284811:AGOS AGR097W
gene id: 284811:AGOS_AGR097W
uniprot id: Q74ZV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

284811:AGOS AFR683C
gene id: 284811:AGOS_AFR683C
uniprot id: Q751Z2
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS AGR225C
gene id: 284811:AGOS_AGR225C
uniprot id: Q74ZW4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm

284811:AGOS AAL022W
gene id: 284811:AGOS_AAL022W
uniprot id: Q75ET8
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

284811:AGOS AGL136C
gene id: 284811:AGOS_AGL136C
uniprot id: Q750S5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a COP9 signalosome-like (CSN) complex.
messages: Component of the COP9 signalosome (CSN) complex that acts as a regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The complex is involved in the regulation of the mating pheromone response (By similarity).
messages: Cytoplasm
messages: Nucleus

284811:AGOS AEL003C
gene id: 284811:AGOS_AEL003C
uniprot id: Q757L4
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by ESA1 to form H2AK4ac and H2AK7ac.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: In contrast to vertebrates and insects, its C-terminus is not monoubiquitinated.
messages: Nucleus
messages: Phosphorylated to form H2AS128ph (gamma-H2A) in response to DNA double-strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks. Phosphorylation is dependent on the DNA damage checkpoint kinases MEC1/ATR and TEL1/ATM, spreads on either side of a detected DSB site and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. Gamma-H2A is removed from the DNA prior to the strand invasion-primer extension step of the repair process and subsequently dephosphorylated by PPH3, a component of the histone H2A phosphatase complex (HTP-C). Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).
messages: Sumoylation on Lys-126 may lead to transcriptional repression.
messages: The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2AK4ac = acetylated Lys-4; H2AK7ac = acetylated Lys-7; H2AS128ph = phosphorylated Ser-128.

284811:AGOS AGR288W
gene id: 284811:AGOS_AGR288W
uniprot id: Q74ZB1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

284811:AGOS AER070C
gene id: 284811:AGOS_AER070C
uniprot id: Q757E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Dus family. Dus3 subfamily.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity). Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity).
messages: Cytoplasm
messages: Nucleus

284811:AGOS AGL148C
gene id: 284811:AGOS_AGL148C
uniprot id: Q750T7
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

284811:AGOS ADL319W
gene id: 284811:AGOS_ADL319W
uniprot id: Q75B89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FES1 family.
messages: Cytoplasm
messages: Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity).

284811:AGOS AFR366W
gene id: 284811:AGOS_AFR366W
uniprot id: O74267
names: Similarity
names: Subunit
messages: Belongs to the threonine aldolase family.
messages: Homotetramer.

284811:AGOS ADR029W
gene id: 284811:AGOS_ADR029W
uniprot id: Q75A89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: nucleolus

284811:AGOS ACL086C
gene id: 284811:AGOS_ACL086C
uniprot id: Q75CK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NST1 family.
messages: Cytoplasm
messages: May act as a negative regulator of salt tolerance.

284811:AGOS AFR243C
gene id: 284811:AGOS_AFR243C
uniprot id: Q753T3
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

284811:AGOS AGL215W
gene id: 284811:AGOS_AGL215W
uniprot id: Q751C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM39 family.
messages: Mitochondrion membrane

284811:AGOS AGL157C
gene id: 284811:AGOS_AGL157C
uniprot id: Q750U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

284811:AGOS AEL299W
gene id: 284811:AGOS_AEL299W
uniprot id: Q758Q2
names: Similarity
messages: Belongs to the YIP1 family.

284811:AGOS AGL063C
gene id: 284811:AGOS_AGL063C
uniprot id: Q750M0
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR637W
gene id: 284811:AGOS_AFR637W
uniprot id: Q752D9
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

284811:AGOS ABR209W
gene id: 284811:AGOS_ABR209W
uniprot id: Q75D13
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

284811:AGOS AEL227C
gene id: 284811:AGOS_AEL227C
uniprot id: Q758I9
names: Subcellular Location Annotation
messages: Peroxisome membrane

284811:AGOS ABR140C
gene id: 284811:AGOS_ABR140C
uniprot id: Q75D84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.

284811:AGOS ACR289W
gene id: 284811:AGOS_ACR289W
uniprot id: Q75BI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

284811:AGOS ABR217C
gene id: 284811:AGOS_ABR217C
uniprot id: Q75D05
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AGR049W
gene id: 284811:AGOS_AGR049W
uniprot id: Q750A8
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AGL105W
gene id: 284811:AGOS_AGL105W
uniprot id: Q750P7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex SPC19 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
messages: Nucleus
messages: The DASH complex oligomerizes to form rings that encircle the microtubules.
messages: kinetochore
messages: spindle

284811:AGOS ABL027W
gene id: 284811:AGOS_ABL027W
uniprot id: Q75DP4
names: Similarity
messages: Belongs to the RRN3 family.

284811:AGOS ACR154W
gene id: 284811:AGOS_ACR154W
uniprot id: Q75BW7
names: Similarity
messages: Belongs to the beclin family.

284811:AGOS AER014W
gene id: 284811:AGOS_AER014W
uniprot id: Q757J9
names: Similarity
messages: Belongs to the TrpF family.

284811:AGOS ABL049C
gene id: 284811:AGOS_ABL049C
uniprot id: Q75DR6
names: Similarity
messages: Belongs to the KTI12 family.

284811:AGOS AFR196C
gene id: 284811:AGOS_AFR196C
uniprot id: Q753X6
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6A family.

284811:AGOS ADR377W
gene id: 284811:AGOS_ADR377W
uniprot id: Q759A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
messages: nucleolus

284811:AGOS ABL110W
gene id: 284811:AGOS_ABL110W
uniprot id: Q75DY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: nuclear pore complex

284811:AGOS AER177W
gene id: 284811:AGOS_AER177W
uniprot id: Q756S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEC1 family.
messages: Nucleus

284811:AGOS ADL272W
gene id: 284811:AGOS_ADL272W
uniprot id: Q75B49
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADL089C
gene id: 284811:AGOS_ADL089C
uniprot id: Q75B03
names: Similarity
messages: Belongs to the peptidase C48 family.

284811:AGOS AER219C
gene id: 284811:AGOS_AER219C
uniprot id: Q756N5
names: Subcellular Location Annotation
messages: Cytoplasm

284811:AGOS ADL087W
gene id: 284811:AGOS_ADL087W
uniprot id: Q75AL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Mitochondrion outer membrane
messages: Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.
messages: NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.

284811:AGOS AFR074C
gene id: 284811:AGOS_AFR074C
uniprot id: Q754J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEATR1/UTP10 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity).
messages: nucleolus

284811:AGOS AGL064W
gene id: 284811:AGOS_AGL064W
uniprot id: Q750M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS AGR202W
gene id: 284811:AGOS_AGR202W
uniprot id: Q74ZJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy (By similarity).

284811:AGOS ABR125C
gene id: 284811:AGOS_ABR125C
uniprot id: Q75D99
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AAL133W
gene id: 284811:AGOS_AAL133W
uniprot id: Q75F61
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

284811:AGOS AFL027C
gene id: 284811:AGOS_AFL027C
uniprot id: Q754U8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity).
messages: Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.
messages: Nucleus
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

284811:AGOS ABL128W
gene id: 284811:AGOS_ABL128W
uniprot id: Q75E01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

284811:AGOS ABR216W
gene id: 284811:AGOS_ABR216W
uniprot id: Q75D06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion inner membrane
messages: Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.

284811:AGOS AGR281C
gene id: 284811:AGOS_AGR281C
uniprot id: Q74ZB8
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

284811:AGOS AFR312W
gene id: 284811:AGOS_AFR312W
uniprot id: Q753K0
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AEL213W
gene id: 284811:AGOS_AEL213W
uniprot id: Q758H5
names: Similarity
messages: Belongs to the TFIIB family.

284811:AGOS AER044W
gene id: 284811:AGOS_AER044W
uniprot id: Q757G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC6 subfamily.
messages: Chromosome
messages: Nucleus

284811:AGOS AFL074C
gene id: 284811:AGOS_AFL074C
uniprot id: Q754Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS AGR299W
gene id: 284811:AGOS_AGR299W
uniprot id: Q74ZA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETT1 family.
messages: Nucleus
messages: Required for correct translation termination and probably involved in regulation of hypoxic gene expression.

284811:AGOS ACR221W
gene id: 284811:AGOS_ACR221W
uniprot id: Q75BQ0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

284811:AGOS AFR474W
gene id: 284811:AGOS_AFR474W
uniprot id: Q752U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

284811:AGOS AFL100W
gene id: 284811:AGOS_AFL100W
uniprot id: Q755C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM1 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase.

284811:AGOS ADR201W
gene id: 284811:AGOS_ADR201W
uniprot id: Q759S2
names: Similarity
messages: Belongs to the UPF0538 family.

284811:AGOS ADR141W
gene id: 284811:AGOS_ADR141W
uniprot id: Q759Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the palI/RIM9 family.
messages: Cell membrane
messages: Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.

284811:AGOS AER388C
gene id: 284811:AGOS_AER388C
uniprot id: Q755Y0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Early endosome membrane
messages: Golgi apparatus membrane
messages: Palmitoyltransferase specific for casein kinase 1.
messages: The DHHC domain is required for palmitoyltransferase activity.

284811:AGOS AGR332C
gene id: 284811:AGOS_AGR332C
uniprot id: Q74Z74
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

284811:AGOS AFR075C
gene id: 284811:AGOS_AFR075C
uniprot id: Q754J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

284811:AGOS AEL214C
gene id: 284811:AGOS_AEL214C
uniprot id: Q758H6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. CPD1 family.
messages: Golgi apparatus
messages: Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing.

284811:AGOS AEL186W
gene id: 284811:AGOS_AEL186W
uniprot id: Q758E8
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

284811:AGOS ACR093C
gene id: 284811:AGOS_ACR093C
uniprot id: Q75C24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BIG1 family.
messages: Endoplasmic reticulum membrane
messages: Required for normal beta-1,6-glucan synthesis.

284811:AGOS AGR218C
gene id: 284811:AGOS_AGR218C
uniprot id: Q74ZI4
names: Subunit
messages: Homodimer.

284811:AGOS AFR502C
gene id: 284811:AGOS_AFR502C
uniprot id: Q752S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus

284811:AGOS AGR273C
gene id: 284811:AGOS_AGR273C
uniprot id: Q74ZC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome
messages: Nucleus
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

284811:AGOS AAL163W
gene id: 284811:AGOS_AAL163W
uniprot id: Q75F94
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AEL076C
gene id: 284811:AGOS_AEL076C
uniprot id: Q757T8
names: Similarity
messages: Belongs to the pyridoxine kinase family.

284811:AGOS AFR360W
gene id: 284811:AGOS_AFR360W
uniprot id: Q753F4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
messages: Mitochondrion intermembrane space

284811:AGOS ADR098C
gene id: 284811:AGOS_ADR098C
uniprot id: Q75A22
names: Similarity
messages: Belongs to the Rho GDI family.

284811:AGOS AAL017W
gene id: 284811:AGOS_AAL017W
uniprot id: Q876Z1
names: Similarity
messages: Belongs to the UPF0357 family.

284811:AGOS AGL154W
gene id: 284811:AGOS_AGL154W
uniprot id: Q750U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

284811:AGOS AAL063C
gene id: 284811:AGOS_AAL063C
uniprot id: Q75EZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

284811:AGOS AGL010W
gene id: 284811:AGOS_AGL010W
uniprot id: Q750G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity).
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
messages: Nucleus

284811:AGOS ACL109C
gene id: 284811:AGOS_ACL109C
uniprot id: Q75CM8
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: The active site is a redox-active disulfide bond.

284811:AGOS ACR021W
gene id: 284811:AGOS_ACR021W
uniprot id: Q75C95
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.

284811:AGOS ABL057W
gene id: 284811:AGOS_ABL057W
uniprot id: Q75DT3
names: Similarity
messages: Belongs to the p23/wos2 family.

284811:AGOS AFR302W
gene id: 284811:AGOS_AFR302W
uniprot id: Q753L0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

284811:AGOS AFR734C
gene id: 284811:AGOS_AFR734C
uniprot id: Q751U1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Component of the nucleolar and nucleoplasmic pre-60S ribosomal particle.
messages: Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

284811:AGOS AER382W
gene id: 284811:AGOS_AER382W
uniprot id: Q755Y5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

284811:AGOS ACL183W
gene id: 284811:AGOS_ACL183W
uniprot id: Q75CX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
messages: Mitochondrion inner membrane

284811:AGOS AAL151C
gene id: 284811:AGOS_AAL151C
uniprot id: Q75F79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AER343C
gene id: 284811:AGOS_AER343C
uniprot id: Q756C4
names: Similarity
messages: Belongs to the EFR3 family.

284811:AGOS ADL179C
gene id: 284811:AGOS_ADL179C
uniprot id: Q75AU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

284811:AGOS AER379C
gene id: 284811:AGOS_AER379C
uniprot id: Q755Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

284811:AGOS AFR498W
gene id: 284811:AGOS_AFR498W
uniprot id: Q752S5
names: Similarity
messages: Belongs to the cullin family.

284811:AGOS AER246W
gene id: 284811:AGOS_AER246W
uniprot id: Q756K8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Methyltransferase which mediates trimethylation of cytochrome c (CYC1).
messages: The SET-like region, although related with the SET domain is not detected by any prediction method.
messages: cytosol

284811:AGOS ACR124W
gene id: 284811:AGOS_ACR124W
uniprot id: Q75BZ5
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

284811:AGOS ADL188C
gene id: 284811:AGOS_ADL188C
uniprot id: Q75AV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners (By similarity).

284811:AGOS AFL063W
gene id: 284811:AGOS_AFL063W
uniprot id: Q754X9
names: Similarity
messages: Belongs to the NAD kinase family.

284811:AGOS ACL083C
gene id: 284811:AGOS_ACL083C
uniprot id: Q75CK2
names: Similarity
messages: Belongs to the PP2C family.

284811:AGOS AGR298C
gene id: 284811:AGOS_AGR298C
uniprot id: Q74ZA5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

284811:AGOS ACR182C
gene id: 284811:AGOS_ACR182C
uniprot id: Q75BT9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Homooctamer.

284811:AGOS AFR547W
gene id: 284811:AGOS_AFR547W
uniprot id: Q752M7
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

284811:AGOS ADL054W
gene id: 284811:AGOS_ADL054W
uniprot id: Q75AI1
names: Function
names: Similarity
messages: Belongs to the WD repeat DSE1 family.
messages: Involved in cell wall metabolism and required for the separation of the mother and daughter cells.

284811:AGOS ABR007C
gene id: 284811:AGOS_ABR007C
uniprot id: Q75DS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: Heterodimer of an alpha and a beta subunit.

284811:AGOS AER433W
gene id: 284811:AGOS_AER433W
uniprot id: Q755T5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHZ1 family.
messages: Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.
messages: Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B (By similarity).
messages: Nucleus

284811:AGOS ADL258W
gene id: 284811:AGOS_ADL258W
uniprot id: Q75B35
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AER270W
gene id: 284811:AGOS_AER270W
uniprot id: Q756J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

284811:AGOS AER450C
gene id: 284811:AGOS_AER450C
uniprot id: Q755R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS AGL062C
gene id: 284811:AGOS_AGL062C
uniprot id: Q750L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF5 family.
messages: Nucleus

284811:AGOS AAR088W
gene id: 284811:AGOS_AAR088W
uniprot id: Q75EJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRG8 family.
messages: Mitochondrion
messages: Required for respiratory activity and maintenance and expression of the mitochondrial genome.

284811:AGOS AFR165C
gene id: 284811:AGOS_AFR165C
uniprot id: Q754A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

284811:AGOS AFR583W
gene id: 284811:AGOS_AFR583W
uniprot id: Q752J2
names: Similarity
messages: Belongs to the heat shock protein 70 family.

284811:AGOS AFL180C
gene id: 284811:AGOS_AFL180C
uniprot id: Q755Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WHI5/NRM1 family.
messages: Cytoplasm
messages: Nucleus

284811:AGOS AEL107W
gene id: 284811:AGOS_AEL107W
uniprot id: Q757W9
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

284811:AGOS ADL185W
gene id: 284811:AGOS_ADL185W
uniprot id: Q75AV5
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AER323W
gene id: 284811:AGOS_AER323W
uniprot id: Q756F6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the SRB8-11 complex, which itself associates with the Mediator complex.
messages: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
messages: Nucleus

284811:AGOS ACL198W
gene id: 284811:AGOS_ACL198W
uniprot id: Q75CW4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Mitochondrion

284811:AGOS AGR037C
gene id: 284811:AGOS_AGR037C
uniprot id: Q750C0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

284811:AGOS AFL220C
gene id: 284811:AGOS_AFL220C
uniprot id: Q755Q7
names: Similarity
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.

284811:AGOS ADR304W
gene id: 284811:AGOS_ADR304W
uniprot id: Q759I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STE12 transcription factor family.
messages: Nucleus

284811:AGOS AER410W
gene id: 284811:AGOS_AER410W
uniprot id: Q755V8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
messages: Homodimer.

284811:AGOS ADR336C
gene id: 284811:AGOS_ADR336C
uniprot id: Q759E1
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADL166W
gene id: 284811:AGOS_ADL166W
uniprot id: Q75AT6
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

284811:AGOS AFR332W
gene id: 284811:AGOS_AFR332W
uniprot id: Q753I0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS4/SLD5 family.
messages: Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity).

284811:AGOS AAR002W
gene id: 284811:AGOS_AAR002W
uniprot id: Q75ES7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

284811:AGOS ACR190C
gene id: 284811:AGOS_ACR190C
uniprot id: Q75BT1
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

284811:AGOS ADR258W
gene id: 284811:AGOS_ADR258W
uniprot id: Q759L8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

284811:AGOS AER374C
gene id: 284811:AGOS_AER374C
uniprot id: Q755Z3
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

284811:AGOS ADR260C
gene id: 284811:AGOS_ADR260C
uniprot id: Q759L6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity).
messages: Belongs to the DEAD box helicase family. DECD subfamily.
messages: Nucleus
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

284811:AGOS AAL074C
gene id: 284811:AGOS_AAL074C
uniprot id: Q75F02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Mitochondrion
messages: Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria (By similarity).

284811:AGOS ADL131C
gene id: 284811:AGOS_ADL131C
uniprot id: Q75AQ1
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

284811:AGOS ADL035C
gene id: 284811:AGOS_ADL035C
uniprot id: Q75AF2
names: Function
names: Similarity
messages: Accepts the ubiquitin-like protein NEDD8/RUB1 from the UBA3-ULA1 E1 complex and catalyzes its covalent attachment to other proteins.
messages: Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.

284811:AGOS ACL111W
gene id: 284811:AGOS_ACL111W
uniprot id: Q75CN0
names: Similarity
messages: Belongs to the RCAN family.

284811:AGOS ACR213W
gene id: 284811:AGOS_ACR213W
uniprot id: Q75BQ8
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

284811:AGOS AEL330C
gene id: 284811:AGOS_AEL330C
uniprot id: Q758T2
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Probable serine/threonine protein kinase which may function redundantly with MPK1-independent branch of the PCK1 pathway.

284811:AGOS ADR058C
gene id: 284811:AGOS_ADR058C
uniprot id: Q75A61
names: Similarity
messages: Belongs to the protein kinase superfamily.

284811:AGOS AEL145W
gene id: 284811:AGOS_AEL145W
uniprot id: Q758D6
names: Subcellular Location Annotation
messages: Mitochondrion

284811:AGOS AFR425C
gene id: 284811:AGOS_AFR425C
uniprot id: Q752Z9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

284811:AGOS AFL116W
gene id: 284811:AGOS_AFL116W
uniprot id: Q755D9
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

284811:AGOS ADR061C
gene id: 284811:AGOS_ADR061C
uniprot id: Q75A58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMN1 family.
messages: Cytoplasm
messages: Negative regulator of the mitotic exit network (MEN), required for multiple cell cycle checkpoints. Required for daughter cell separation and chromosome stability. Involved in copper sensitivity.
messages: Nucleus

284811:AGOS AGL332W
gene id: 284811:AGOS_AGL332W
uniprot id: Q751M9
names: Similarity
messages: Belongs to the REXO1/REXO3 family.

284811:AGOS AEL212W
gene id: 284811:AGOS_AEL212W
uniprot id: Q758H4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

284811:AGOS AGR219W
gene id: 284811:AGOS_AGR219W
uniprot id: Q74ZI3
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

284811:AGOS ADR401C
gene id: 284811:AGOS_ADR401C
uniprot id: Q758X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

284811:AGOS AFR064C
gene id: 284811:AGOS_AFR064C
uniprot id: Q754K8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
messages: Cytoplasm
messages: Inhibited by both FK506 and rapamycin.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

284811:AGOS AER296W
gene id: 284811:AGOS_AER296W
uniprot id: Q756H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

284811:AGOS AAL005W
gene id: 284811:AGOS_AAL005W
uniprot id: Q75EU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

284811:AGOS ABL205C
gene id: 284811:AGOS_ABL205C
uniprot id: Q75E78
names: Function
names: Similarity
messages: Belongs to the NARF family.
messages: Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins (By similarity).

284811:AGOS AGL118W
gene id: 284811:AGOS_AGL118W
uniprot id: Q750R0
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

284811:AGOS AAR177W
gene id: 284811:AGOS_AAR177W
uniprot id: Q75EA0
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

284811:AGOS ABR036W
gene id: 284811:AGOS_ABR036W
uniprot id: Q75DI8
names: Similarity
messages: Belongs to the AAA ATPase family.

284811:AGOS AFR248C
gene id: 284811:AGOS_AFR248C
uniprot id: Q753S8
names: Function
names: Similarity
messages: Belongs to the IRC6 family.
messages: Involved in gross chromosomal rearrangements (GCRs) and telomere healing.

284811:AGOS ACR170C
gene id: 284811:AGOS_ACR170C
uniprot id: Q75BV1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

284811:AGOS AGR389C
gene id: 284811:AGOS_AGR389C
uniprot id: Q74Z17
names: Similarity
messages: Belongs to the peptidase C19 family.

284811:AGOS ABR163W
gene id: 284811:AGOS_ABR163W
uniprot id: Q75D60
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

284811:AGOS AER096C
gene id: 284811:AGOS_AER096C
uniprot id: Q757B7
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the calcineurin regulatory subunit family.
messages: Composed of a catalytic subunit (A) and a regulatory subunit (B).
messages: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity).
messages: This protein has four functional calcium-binding sites.

284811:AGOS AGL267C
gene id: 284811:AGOS_AGL267C
uniprot id: Q751H3
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

284811:AGOS AFL006C
gene id: 284811:AGOS_AFL006C
uniprot id: Q754S7
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AER372C
gene id: 284811:AGOS_AER372C
uniprot id: Q755Z5
names: Similarity
messages: Belongs to the SUN family.

284811:AGOS ADL284C
gene id: 284811:AGOS_ADL284C
uniprot id: Q75B56
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

284811:AGOS AFL218C
gene id: 284811:AGOS_AFL218C
uniprot id: Q755N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Membrane

284811:AGOS ABR076C
gene id: 284811:AGOS_ABR076C
uniprot id: Q75DF0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

284811:AGOS AGR272W
gene id: 284811:AGOS_AGR272W
uniprot id: Q74ZC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Mitochondrion inner membrane

284811:AGOS AGL060W
gene id: 284811:AGOS_AGL060W
uniprot id: Q750L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Peroxisome

284811:AGOS AEL085W
gene id: 284811:AGOS_AEL085W
uniprot id: Q757U7
names: Similarity
messages: Belongs to the SF3A3 family.

284811:AGOS AER415W
gene id: 284811:AGOS_AER415W
uniprot id: Q755V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

284811:AGOS AAR042W
gene id: 284811:AGOS_AAR042W
uniprot id: Q75EN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHE3 family.
messages: Endoplasmic reticulum membrane
messages: RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Required for the delivery of cortical endoplasmic reticulum into the emerging bud (By similarity).

284811:AGOS ADL002C
gene id: 284811:AGOS_ADL002C
uniprot id: Q75AB9
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

284811:AGOS ADL194W
gene id: 284811:AGOS_ADL194W
uniprot id: Q75AW4
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues (By similarity).

284811:AGOS ACL019C
gene id: 284811:AGOS_ACL019C
uniprot id: Q75CC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HRD1 family.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD). Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity).
messages: Endoplasmic reticulum membrane
messages: Interacts with HRD3.

284811:AGOS ADL032W
gene id: 284811:AGOS_ADL032W
uniprot id: Q75AE9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Mitochondrion

284811:AGOS AFL012C
gene id: 284811:AGOS_AFL012C
uniprot id: Q754T3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage (By similarity).
messages: Heterotetramer composed of SEN2, SEN15, SEN34 and SEN54. Interacts directly with SEN15 (By similarity).

284811:AGOS ADL137W
gene id: 284811:AGOS_ADL137W
uniprot id: Q75AQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTC6 family.
messages: May be involved in telomere capping.
messages: Membrane

284811:AGOS AEL134W
gene id: 284811:AGOS_AEL134W
uniprot id: Q757Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRE9/KNH1 family.
messages: Involved in cell wall beta(1->6) glucan synthesis.
messages: cell wall

284811:AGOS ACL099W
gene id: 284811:AGOS_ACL099W
uniprot id: Q75CL8
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AER124W
gene id: 284811:AGOS_AER124W
uniprot id: Q756Z0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Inhibited by organophosphorus esters.
messages: Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).

284811:AGOS AFR530W
gene id: 284811:AGOS_AFR530W
uniprot id: Q752P3
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

284811:AGOS AAR061W
gene id: 284811:AGOS_AAR061W
uniprot id: Q75EL8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

284811:AGOS ACR191C
gene id: 284811:AGOS_ACR191C
uniprot id: Q75BT0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

284811:AGOS AGL013W
gene id: 284811:AGOS_AGL013W
uniprot id: Q750G6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

284811:AGOS AAR153C
gene id: 284811:AGOS_AAR153C
uniprot id: Q75EC1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Expected to bind 2 Fe(2+) ions per subunit.
messages: Membrane
messages: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.

284811:AGOS AAL160W
gene id: 284811:AGOS_AAL160W
uniprot id: Q75FA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

284811:AGOS ACR010C
gene id: 284811:AGOS_ACR010C
uniprot id: Q8J1G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.
messages: Required for assembly of the mitotic spindle. Interacts with spindle microtubules to produce an outwardly directed force acting upon the poles. Following spindle assembly, CIN8 and KIP1 apparently act to oppose a force that draws separated poles back together. This force seems to be mediated by KAR3 (By similarity).
messages: spindle

284811:AGOS AGL107W
gene id: 284811:AGOS_AGL107W
uniprot id: Q750P9
names: Similarity
messages: Belongs to the LipB family.

284811:AGOS ADR387W
gene id: 284811:AGOS_ADR387W
uniprot id: Q758Z0
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

284811:AGOS AGR100W
gene id: 284811:AGOS_AGR100W
uniprot id: Q74ZU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

284811:AGOS ADL199W
gene id: 284811:AGOS_ADL199W
uniprot id: Q75AW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.

284811:AGOS AGL129W
gene id: 284811:AGOS_AGL129W
uniprot id: Q750R8
names: Similarity
messages: Belongs to the phosducin family.

284811:AGOS AER259W
gene id: 284811:AGOS_AER259W
uniprot id: Q756J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: Involved in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity).
messages: nucleolus

284811:AGOS AGL299C
gene id: 284811:AGOS_AGL299C
uniprot id: Q751K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG3 family.
messages: Endoplasmic reticulum membrane

284811:AGOS ACR095W
gene id: 284811:AGOS_ACR095W
uniprot id: Q75C22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Could act as an H1-type linker histone.
messages: Nucleus

284811:AGOS AER368C
gene id: 284811:AGOS_AER368C
uniprot id: Q755Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM2 family.
messages: Cytoplasm
messages: Involved in chromosome segregation during meiosis. Promotes efficient recombinational repair and functions in the protection of the genome from spontaneous and induced DNA damage like mutations and gross chromosomal rearrangements (GCRs) (By similarity).
messages: Nucleus

284811:AGOS AGR204W
gene id: 284811:AGOS_AGR204W
uniprot id: Q74ZJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRO1 family.
messages: Cytoplasm
messages: Endosome
messages: Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles.

284811:AGOS AER012C
gene id: 284811:AGOS_AER012C
uniprot id: Q757K0
uniprot id: Q75AX1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).

284811:AGOS AFR409W
gene id: 284811:AGOS_AFR409W
uniprot id: Q753B5
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

284811:AGOS AGR121C
gene id: 284811:AGOS_AGR121C
uniprot id: Q74ZS7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

284811:AGOS AFR120C
gene id: 284811:AGOS_AFR120C
uniprot id: Q754F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: May be involved in cellular response to stress. Required to maintain mitochondrial DNA (mtDNA) integrity and stability (By similarity).
messages: Mitochondrion inner membrane

284811:AGOS AFR408C
gene id: 284811:AGOS_AFR408C
uniprot id: Q753B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.
messages: cis-Golgi network

284811:AGOS AFR067W
gene id: 284811:AGOS_AFR067W
uniprot id: Q754K5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

284811:AGOS ABR069W
gene id: 284811:AGOS_ABR069W
uniprot id: Q75DF7
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

284811:AGOS AER314W
gene id: 284811:AGOS_AER314W
uniprot id: Q756F1
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AAL124W
gene id: 284811:AGOS_AAL124W
uniprot id: Q75F52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: Cytoplasm
messages: nucleolus

284811:AGOS ABR003W
gene id: 284811:AGOS_ABR003W
uniprot id: Q75DL5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.

284811:AGOS ACL113C
gene id: 284811:AGOS_ACL113C
uniprot id: Q75CN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YPP1 family.
messages: Cell membrane
messages: Cytoplasmic granule
messages: Involved in endocytosis.

284811:AGOS AAL122C
gene id: 284811:AGOS_AAL122C
uniprot id: Q75F50
names: Similarity
messages: Belongs to the RMD1/sif2 family.

284811:AGOS AFL168W
gene id: 284811:AGOS_AFL168W
uniprot id: Q755J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

284811:AGOS AER228C
gene id: 284811:AGOS_AER228C
uniprot id: Q756M6
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

284811:AGOS AFL133C
gene id: 284811:AGOS_AFL133C
uniprot id: Q755F6
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

284811:AGOS ACL015W
gene id: 284811:AGOS_ACL015W
uniprot id: Q75CC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: nucleolus

284811:AGOS AER333C
gene id: 284811:AGOS_AER333C
uniprot id: Q756D4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPI19 family.
messages: Component of the phosphatidylinositol N-acetylglucosaminyltransferase complex.
messages: Endoplasmic reticulum membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Involved in cell wall biosynthesis (By similarity).

284811:AGOS ABR043W
gene id: 284811:AGOS_ABR043W
uniprot id: Q75DI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

284811:AGOS AGL114C
gene id: 284811:AGOS_AGL114C
uniprot id: Q750Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

284811:AGOS ABL180W
gene id: 284811:AGOS_ABL180W
uniprot id: Q75E50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).
messages: Nucleus
messages: telomere

284811:AGOS AER034C
gene id: 284811:AGOS_AER034C
uniprot id: Q757H9
names: Similarity
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.

284811:AGOS AEL148W
gene id: 284811:AGOS_AEL148W
uniprot id: Q758D4
names: Similarity
messages: Belongs to the MNN1/MNT family.

284811:AGOS AAL078W
gene id: 284811:AGOS_AAL078W
uniprot id: Q75F06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane

284811:AGOS AER309W
gene id: 284811:AGOS_AER309W
uniprot id: Q756F7
names: Similarity
messages: Belongs to the guanylate kinase family.

284811:AGOS AER013W
gene id: 284811:AGOS_AER013W
uniprot id: Q757N1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of histone H3 leads to transcriptional activation. H3K14ac formation by GCN5 is promoted by H3S10ph. H3K14ac can also be formed by ESA1. H3K56ac formation occurs predominantly in newly synthesized H3 molecules during G1, S and G2/M of the cell cycle and may be involved in DNA repair (By similarity).
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Mono-, di- and trimethylated by the COMPASS complex to form H3K4me1/2/3. H3K4me activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance. H3K4me enrichment correlates with transcription levels, and occurs in a 5' to 3' gradient with H3K4me3 enrichment at the 5'-end of genes, shifting to H3K4me2 and then H3K4me1. Methylated by SET2 to form H3K36me. H3K36me represses gene expression. Methylated by DOT1 to form H3K79me. H3K79me is required for association of SIR proteins with telomeric regions and for telomeric silencing. The COMPASS-mediated formation of H3K4me2/3 and the DOT1-mediated formation of H3K79me require H2BK123ub1 (By similarity).
messages: Nucleus
messages: Phosphorylated by IPL1 to form H3S10ph. H3S10ph promotes subsequent H3K14ac formation by GCN5 and is required for transcriptional activation through TBP recruitment to the promoters (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me1 = monomethylated Lys-10; H3S10ph = phosphorylated Ser-11; H3K14ac = acetylated Lys-15; H3K14me2 = dimethylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K27ac = acetylated Lys-28; H3K27me1/2/3 = mono-, di- and trimethylated Lys-28; H3K36ac = acetylated Lys-37; H3K36me1/2/3 = mono-, di- and trimethylated Lys-37; H3K56ac = acetylated Lys-57; H3K64ac = acetylated Lys-65; H3K79me1/2/3 = mono-, di- and trimethylated Lys-80.

284811:AGOS ADR231C
gene id: 284811:AGOS_ADR231C
uniprot id: Q759P4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLPL family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lipid hydrolase.
messages: Membrane

284811:AGOS AFR598C
gene id: 284811:AGOS_AFR598C
uniprot id: Q752H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

284811:AGOS ADL252W
gene id: 284811:AGOS_ADL252W
uniprot id: Q9HF51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Involved in the regulation of actin polarization. Rho proteins are required for distinct steps during polarized hyphal growth of A.gossypii.

284811:AGOS AFR100W
gene id: 284811:AGOS_AFR100W
uniprot id: Q754H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO70 family.
messages: Bud
messages: Bud neck
messages: Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst (By similarity).

284811:AGOS AFR116W
gene id: 284811:AGOS_AFR116W
uniprot id: Q754F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferric reductase (FRE) family. AIM14 subfamily.
messages: Membrane
messages: Probable cell surface metalloreductase. May be involved in iron or copper homeostasis (By similarity).

284811:AGOS AGR222W
gene id: 284811:AGOS_AGR222W
uniprot id: Q74ZI0
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

284811:AGOS AAL175W
gene id: 284811:AGOS_AAL175W
uniprot id: Q75F91
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ABL093W
gene id: 284811:AGOS_ABL093W
uniprot id: Q75DW6
names: Similarity
messages: Belongs to the VPS54 family.

284811:AGOS AFL120W
gene id: 284811:AGOS_AFL120W
uniprot id: Q755E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

284811:AGOS AFL090W
gene id: 284811:AGOS_AFL090W
uniprot id: Q755B5
names: Similarity
messages: Belongs to the protein kinase superfamily.

284811:AGOS AGL089W
gene id: 284811:AGOS_AGL089W
uniprot id: Q750N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

284811:AGOS AFL167C
gene id: 284811:AGOS_AFL167C
uniprot id: Q755J0
names: Similarity
messages: Belongs to the glycosyl hydrolase 63 family.

284811:AGOS AFR403W
gene id: 284811:AGOS_AFR403W
uniprot id: Q753Q5
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

284811:AGOS ADL046C
gene id: 284811:AGOS_ADL046C
uniprot id: Q75AG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm
messages: Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.

284811:AGOS ACR206C
gene id: 284811:AGOS_ACR206C
uniprot id: Q75BR5
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

284811:AGOS ADR050W
gene id: 284811:AGOS_ADR050W
uniprot id: Q75A68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

284811:AGOS AFR645W
gene id: 284811:AGOS_AFR645W
uniprot id: Q752D0
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AGR371C
gene id: 284811:AGOS_AGR371C
uniprot id: Q74Z35
names: Function
names: Similarity
messages: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

284811:AGOS AFR436C
gene id: 284811:AGOS_AFR436C
uniprot id: Q752Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

284811:AGOS AGL053C
gene id: 284811:AGOS_AGL053C
uniprot id: Q750K4
names: Similarity
messages: Belongs to the TACO1 family.

284811:AGOS AGL005W
gene id: 284811:AGOS_AGL005W
uniprot id: Q750F9
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.

284811:AGOS ACL013C
gene id: 284811:AGOS_ACL013C
uniprot id: Q75CC2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM12 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane
messages: The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.

284811:AGOS ADR059C
gene id: 284811:AGOS_ADR059C
uniprot id: Q75A60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
messages: Endoplasmic reticulum membrane

284811:AGOS AER031C
gene id: 284811:AGOS_AER031C
uniprot id: Q757I2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

284811:AGOS AFR213C
gene id: 284811:AGOS_AFR213C
uniprot id: Q753V9
names: Similarity
messages: Belongs to the PurH family.

284811:AGOS AEL301W
gene id: 284811:AGOS_AEL301W
uniprot id: Q758Q4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

284811:AGOS AFR308W
gene id: 284811:AGOS_AFR308W
uniprot id: Q753K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

284811:AGOS AER162C
gene id: 284811:AGOS_AER162C
uniprot id: Q756U0
names: Similarity
messages: Belongs to the allantoicase family.

284811:AGOS AGR184W
gene id: 284811:AGOS_AGR184W
uniprot id: Q74ZL4
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by ESA1 to form H2AK4ac and H2AK7ac.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: In contrast to vertebrates and insects, its C-terminus is not monoubiquitinated.
messages: Nucleus
messages: Phosphorylated to form H2AS128ph (gamma-H2A) in response to DNA double-strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks. Phosphorylation is dependent on the DNA damage checkpoint kinases MEC1/ATR and TEL1/ATM, spreads on either side of a detected DSB site and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. Gamma-H2A is removed from the DNA prior to the strand invasion-primer extension step of the repair process and subsequently dephosphorylated by PPH3, a component of the histone H2A phosphatase complex (HTP-C). Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).
messages: Sumoylation on Lys-126 may lead to transcriptional repression.
messages: The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2AK4ac = acetylated Lys-4; H2AK7ac = acetylated Lys-7; H2AS128ph = phosphorylated Ser-128.

284811:AGOS AEL294C
gene id: 284811:AGOS_AEL294C
uniprot id: Q758P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

284811:AGOS AGL026W
gene id: 284811:AGOS_AGL026W
uniprot id: Q750H7
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AEL015W
gene id: 284811:AGOS_AEL015W
uniprot id: Q757M3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NUF2 family.
messages: Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.
messages: Nucleus
messages: kinetochore

284811:AGOS AFL047W
gene id: 284811:AGOS_AFL047W
uniprot id: Q754W4
names: Similarity
messages: Belongs to the class-I DAHP synthase family.

284811:AGOS ADL155C
gene id: 284811:AGOS_ADL155C
uniprot id: Q75AS5
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR019W
gene id: 284811:AGOS_AFR019W
uniprot id: Q754Q3
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

284811:AGOS ACL203C
gene id: 284811:AGOS_ACL203C
uniprot id: Q75CW9
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AEL199W
gene id: 284811:AGOS_AEL199W
uniprot id: Q758G1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERF4 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with ERF2.
messages: The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization (By similarity).

284811:AGOS AGL194C
gene id: 284811:AGOS_AGL194C
uniprot id: Q750Y3
names: Function
messages: May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity).

284811:AGOS ACL178C
gene id: 284811:AGOS_ACL178C
uniprot id: Q75CU7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.

284811:AGOS AER327C
gene id: 284811:AGOS_AER327C
uniprot id: Q756E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Nucleus

284811:AGOS AGR023C
gene id: 284811:AGOS_AGR023C
uniprot id: Q750D2
names: Similarity
messages: Belongs to the peptidase C19 family.

284811:AGOS AFR134C
gene id: 284811:AGOS_AFR134C
uniprot id: Q754D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

284811:AGOS AGR368W
gene id: 284811:AGOS_AGR368W
uniprot id: Q74Z38
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

284811:AGOS ABR170W
gene id: 284811:AGOS_ABR170W
uniprot id: Q75D53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GcvT family. CAF17 subfamily.
messages: Mitochondrion

284811:AGOS ADL299C
gene id: 284811:AGOS_ADL299C
uniprot id: Q75B71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

284811:AGOS ABR093C
gene id: 284811:AGOS_ABR093C
uniprot id: Q75DD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcriptional coactivator PC4 family.
messages: Nucleus

284811:AGOS ADL273C
gene id: 284811:AGOS_ADL273C
uniprot id: Q75B50
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity).
messages: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
messages: Cytoplasm
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

284811:AGOS AFL208C
gene id: 284811:AGOS_AFL208C
uniprot id: Q755M2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit. Active with Co(2+), Fe(2+), Mn(2+) and Zn(2+).
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

284811:AGOS ADL047W
gene id: 284811:AGOS_ADL047W
uniprot id: Q75AG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC26 family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing.
messages: Nucleus

284811:AGOS AGR112C
gene id: 284811:AGOS_AGR112C
uniprot id: Q74ZT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

284811:AGOS AEL257W
gene id: 284811:AGOS_AEL257W
uniprot id: Q758L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

284811:AGOS AGL016C
gene id: 284811:AGOS_AGL016C
uniprot id: Q750G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

284811:AGOS AEL328W
gene id: 284811:AGOS_AEL328W
uniprot id: Q758T0
names: Similarity
messages: Belongs to the COG4 family.

284811:AGOS ADR346W
gene id: 284811:AGOS_ADR346W
uniprot id: Q759D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24.
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Cytoplasm
messages: Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles. Activates and recruits ATPase AFG2 to cytoplasmic pre-60S ribosomal particles.
messages: Nucleus

284811:AGOS ADR196W
gene id: 284811:AGOS_ADR196W
uniprot id: Q759S7
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
messages: Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.

284811:AGOS AFR483C
gene id: 284811:AGOS_AFR483C
uniprot id: Q752U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

284811:AGOS AFR744W
gene id: 284811:AGOS_AFR744W
uniprot id: Q751T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.
messages: nucleolus

284811:AGOS ACL191C
gene id: 284811:AGOS_ACL191C
uniprot id: Q75CV7
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

284811:AGOS AFL193W
gene id: 284811:AGOS_AFL193W
uniprot id: Q755Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INP2 family.
messages: Peroxisome membrane
messages: Required for peroxisome inheritance.

284811:AGOS AEL177C
gene id: 284811:AGOS_AEL177C
uniprot id: Q758C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM54 family.
messages: Component of the TIM22 complex, whose core is composed of TIM22 and TIM54, associated with the 70 kDa heterohexamer composed of TIM9 and TIM10 (or TIM8 and TIM13).
messages: Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force (By similarity).
messages: Mitochondrion inner membrane

284811:AGOS ACL112C
gene id: 284811:AGOS_ACL112C
uniprot id: Q75CN1
names: Domain
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DENR family.
messages: Cytoplasm
messages: Interacts with the 40S ribosomal subunit.
messages: The SUI1 domain may be involved in RNA binding.

284811:AGOS AGR085W
gene id: 284811:AGOS_AGR085W
uniprot id: Q74ZX3
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

284811:AGOS ABL183W
gene id: 284811:AGOS_ABL183W
uniprot id: Q75E53
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

284811:AGOS AFR182C
gene id: 284811:AGOS_AFR182C
uniprot id: Q753Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

284811:AGOS ADL253C
gene id: 284811:AGOS_ADL253C
uniprot id: Q75B30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Nucleus

284811:AGOS ABR204C
gene id: 284811:AGOS_ABR204C
uniprot id: Q75D18
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

284811:AGOS ADR115W
gene id: 284811:AGOS_ADR115W
uniprot id: Q75A09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

284811:AGOS ACR256C
gene id: 284811:AGOS_ACR256C
uniprot id: Q75BL5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

284811:AGOS ABL037C
gene id: 284811:AGOS_ABL037C
uniprot id: Q75DQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEG1 family.
messages: Cell membrane
messages: Component of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains termed MCCs on the plasma membrane.
messages: Important for the stabilization of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on the plasma membrane to cluster specific proteins at sites of membrane invaginations.

284811:AGOS AEL088C
gene id: 284811:AGOS_AEL088C
uniprot id: Q757V0
names: Function
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.
messages: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP.

284811:AGOS AGL162C
gene id: 284811:AGOS_AGL162C
uniprot id: Q750V1
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

284811:AGOS AER318C
gene id: 284811:AGOS_AER318C
uniprot id: Q756E7
names: Function
names: Subcellular Location Annotation
messages: Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation.
messages: Nucleus

284811:AGOS AGL019W
gene id: 284811:AGOS_AGL019W
uniprot id: Q750H2
names: Similarity
messages: Belongs to the peptidase C48 family.

284811:AGOS AGR394W
gene id: 284811:AGOS_AGR394W
uniprot id: Q74Z13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.
messages: Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.
messages: Peroxisome membrane
messages: cytosol

284811:AGOS AFL007C
gene id: 284811:AGOS_AFL007C
uniprot id: Q754S8
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

284811:AGOS AER043C
gene id: 284811:AGOS_AER043C
uniprot id: Q757H0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

284811:AGOS ADL214C
gene id: 284811:AGOS_ADL214C
uniprot id: Q75AY4
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

284811:AGOS AAR106C
gene id: 284811:AGOS_AAR106C
uniprot id: Q75EH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom5 family.
messages: Membrane
messages: Mitochondrion outer membrane

284811:AGOS AFR279C
gene id: 284811:AGOS_AFR279C
uniprot id: Q753N3
names: Similarity
messages: Belongs to the hexokinase family.

284811:AGOS AER138C
gene id: 284811:AGOS_AER138C
uniprot id: Q756X6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
messages: Forms a stable heterodimer with SPT16. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex (By similarity).
messages: In contrast to the orthologous protein in animals and plants, this protein does not contain a HMG box DNA-binding domain. This function may instead be provided by the HMG box of the associated NHP6 protein in the FACT complex of fungi.
messages: Nucleus

284811:AGOS ABL054C
gene id: 284811:AGOS_ABL054C
uniprot id: Q75DT0
names: Similarity
messages: Belongs to the AP endonuclease 2 family.

284811:AGOS AEL282W
gene id: 284811:AGOS_AEL282W
uniprot id: Q758N7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).
messages: Nucleus

284811:AGOS ADL290W
gene id: 284811:AGOS_ADL290W
uniprot id: Q75B62
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

284811:AGOS ADR194C
gene id: 284811:AGOS_ADR194C
uniprot id: Q759S9
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.

284811:AGOS AFR062C
gene id: 284811:AGOS_AFR062C
uniprot id: Q754L0
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

284811:AGOS AGL323C
gene id: 284811:AGOS_AGL323C
uniprot id: Q751M0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

284811:AGOS AER257W
gene id: 284811:AGOS_AER257W
uniprot id: Q756J7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

284811:AGOS AGR251C
gene id: 284811:AGOS_AGR251C
uniprot id: Q74ZE8
names: Similarity
messages: Belongs to the peptidase M16 family.

284811:AGOS ABR195C
gene id: 284811:AGOS_ABR195C
uniprot id: Q75D27
names: Subcellular Location Annotation
messages: Mitochondrion outer membrane

284811:AGOS ACL157C
gene id: 284811:AGOS_ACL157C
uniprot id: Q75CS6
names: Similarity
messages: Belongs to the epsin family.

284811:AGOS ADR007C
gene id: 284811:AGOS_ADR007C
uniprot id: Q75AB1
names: Similarity
messages: Belongs to the TFIIB family.

284811:AGOS AAR084W
gene id: 284811:AGOS_AAR084W
uniprot id: Q75EJ5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

284811:AGOS ADR237C
gene id: 284811:AGOS_ADR237C
uniprot id: Q759N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM1 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase.

284811:AGOS ACR167C
gene id: 284811:AGOS_ACR167C
uniprot id: Q75BV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AlaDH/PNT family.
messages: Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.
messages: Monomer.
messages: Peroxisome

284811:AGOS AGL276W
gene id: 284811:AGOS_AGL276W
uniprot id: Q751I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
messages: Mitochondrion outer membrane

284811:AGOS AAR004C
gene id: 284811:AGOS_AAR004C
uniprot id: Q75ES5
names: Similarity
messages: Belongs to the citrate synthase family.

284811:AGOS ABR035C
gene id: 284811:AGOS_ABR035C
uniprot id: Q75DI9
names: Similarity
messages: Belongs to the CWC22 family.

284811:AGOS AFR434W
gene id: 284811:AGOS_AFR434W
uniprot id: Q752Y7
names: Similarity
messages: Belongs to the MOG1 family.

284811:AGOS AAR129C
gene id: 284811:AGOS_AAR129C
uniprot id: Q75EF2
names: Similarity
messages: Belongs to the peptidase M28 family.

284811:AGOS ADR002W
gene id: 284811:AGOS_ADR002W
uniprot id: Q75AB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP16 family.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

284811:AGOS AAR017W
gene id: 284811:AGOS_AAR017W
uniprot id: Q75ER2
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

284811:AGOS AFR313C
gene id: 284811:AGOS_AFR313C
uniprot id: Q753J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

284811:AGOS AAR181W
gene id: 284811:AGOS_AAR181W
uniprot id: Q75ED5
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

284811:AGOS AGR073C
gene id: 284811:AGOS_AGR073C
uniprot id: Q74ZY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. This subunit may anchor the endonuclease complex to the nuclear membrane. Probably carries the active site for 5'-splice site cleavage (By similarity).
messages: Heterotetramer composed of SEN2, SEN15, SEN34 and SEN54. Interacts directly with SEN54 (By similarity).

284811:AGOS ABR169W
gene id: 284811:AGOS_ABR169W
uniprot id: Q75D54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

284811:AGOS AEL084W
gene id: 284811:AGOS_AEL084W
uniprot id: Q757U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

284811:AGOS AFL092C
gene id: 284811:AGOS_AFL092C
uniprot id: Q755B7
names: Subcellular Location Annotation
messages: Cell surface

284811:AGOS AFR198W
gene id: 284811:AGOS_AFR198W
uniprot id: Q753X4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.
messages: Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
messages: Mitochondrion matrix

284811:AGOS ACR086C
gene id: 284811:AGOS_ACR086C
uniprot id: Q75C31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane

284811:AGOS ADR142W
gene id: 284811:AGOS_ADR142W
uniprot id: Q759Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AEP1 family.
messages: Mitochondrion
messages: Required for translation of the mitochondrial OLI1 transcript encoding subunit 9 of mitochondrial ATP synthase.

284811:AGOS AGL206C
gene id: 284811:AGOS_AGL206C
uniprot id: Q750Z3
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ADL281C
gene id: 284811:AGOS_ADL281C
uniprot id: Q75BG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family. PIGB subfamily.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).

284811:AGOS AGR346C
gene id: 284811:AGOS_AGR346C
uniprot id: Q74Z60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with TAN1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

284811:AGOS AFR392C
gene id: 284811:AGOS_AFR392C
uniprot id: Q753C4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SPP2 family.
messages: Involved in spliceosome maturation and the first step of pre-mRNA splicing.
messages: Nucleus

284811:AGOS AFR432W
gene id: 284811:AGOS_AFR432W
uniprot id: Q752Y9
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ABL144C
gene id: 284811:AGOS_ABL144C
uniprot id: Q75E17
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

284811:AGOS ABL125W
gene id: 284811:AGOS_ABL125W
uniprot id: Q75DZ8
names: Cofactor
messages: Binds 1 zinc ion per subunit.

284811:AGOS ACR041W
gene id: 284811:AGOS_ACR041W
uniprot id: Q75C75
names: Similarity
messages: Belongs to the cyclin family.

284811:AGOS AFR447C
gene id: 284811:AGOS_AFR447C
uniprot id: Q752X6
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

284811:AGOS ADR342C
gene id: 284811:AGOS_ADR342C
uniprot id: Q759D5
names: Function
names: Similarity
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.

284811:AGOS AEL029W
gene id: 284811:AGOS_AEL029W
uniprot id: Q757P1
names: Similarity
messages: Belongs to the peptidase C19 family.

284811:AGOS AER149W
gene id: 284811:AGOS_AER149W
uniprot id: Q756V2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

284811:AGOS AGR115C
gene id: 284811:AGOS_AGR115C
uniprot id: Q74ZT3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

284811:AGOS ABR136W
gene id: 284811:AGOS_ABR136W
uniprot id: Q75D88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
messages: Chromosome
messages: Component of the COMPASS (Set1C) complex.
messages: Nucleus

284811:AGOS ADL037W
gene id: 284811:AGOS_ADL037W
uniprot id: Q75AF5
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Involved in vesicular transport between an endosomal compartment and the Golgi apparatus.
messages: The GRIP domain may serve as a Golgi targeting domain.

284811:AGOS AGR380C
gene id: 284811:AGOS_AGR380C
uniprot id: Q74Z26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 5 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS ABL126W
gene id: 284811:AGOS_ABL126W
uniprot id: Q75DZ9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

284811:AGOS AEL121W
gene id: 284811:AGOS_AEL121W
uniprot id: Q757Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS ABL152W
gene id: 284811:AGOS_ABL152W
uniprot id: Q75E22
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

284811:AGOS AFR726W
gene id: 284811:AGOS_AFR726W
uniprot id: Q751U9
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

284811:AGOS ADL154C
gene id: 284811:AGOS_ADL154C
uniprot id: Q75AS4
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

284811:AGOS AFL214C
gene id: 284811:AGOS_AFL214C
uniprot id: Q755M8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Heterotetramer; composed of two copies of TRM6 and two copies of TRM61.
messages: Nucleus

284811:AGOS AFL185W
gene id: 284811:AGOS_AFL185W
uniprot id: Q755Q5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Heterooctamer of 4 alpha and 4 beta chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

284811:AGOS ABL115W
gene id: 284811:AGOS_ABL115W
uniprot id: Q75DY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

284811:AGOS AER436C
gene id: 284811:AGOS_AER436C
uniprot id: Q755T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRG8 family.
messages: Bud
messages: Bud neck
messages: Bud tip
messages: Cytoplasm
messages: Involved in maintenance of polarized growth and daughter-cell-specific transcription.

284811:AGOS AFL184W
gene id: 284811:AGOS_AFL184W
uniprot id: Q755Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INP1 family.
messages: Peroxisome membrane
messages: Required for peroxisome inheritance.

284811:AGOS AFR326W
gene id: 284811:AGOS_AFR326W
uniprot id: Q753I6
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ABR055C
gene id: 284811:AGOS_ABR055C
uniprot id: Q75DH1
names: Similarity
messages: Belongs to the EFG1/PHD1/stuA family.

284811:AGOS ADL030C
gene id: 284811:AGOS_ADL030C
uniprot id: Q75AE7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit.
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

284811:AGOS AER308C
gene id: 284811:AGOS_AER308C
uniprot id: Q756F8
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

284811:AGOS AFR255W
gene id: 284811:AGOS_AFR255W
uniprot id: Q753S1
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

284811:AGOS AER394W
gene id: 284811:AGOS_AER394W
uniprot id: Q755X4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

284811:AGOS AFL154C
gene id: 284811:AGOS_AFL154C
uniprot id: Q755H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Endoplasmic reticulum membrane
messages: May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen. Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum (By similarity).

284811:AGOS AAL075W
gene id: 284811:AGOS_AAL075W
uniprot id: Q75F03
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

284811:AGOS ADL189W
gene id: 284811:AGOS_ADL189W
uniprot id: Q75AV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

284811:AGOS ABL012C
gene id: 284811:AGOS_ABL012C
uniprot id: Q75DM9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS11 family.
messages: Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.
messages: Vacuole membrane

284811:AGOS AGR253W
gene id: 284811:AGOS_AGR253W
uniprot id: Q74ZE6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

284811:AGOS ABL186W
gene id: 284811:AGOS_ABL186W
uniprot id: Q75E56
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).

284811:AGOS AAL027W
gene id: 284811:AGOS_AAL027W
uniprot id: Q75F84
names: Similarity
messages: Belongs to the lysophospholipase family.

284811:AGOS ABL148C
gene id: 284811:AGOS_ABL148C
uniprot id: Q75E80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex, whose core is composed of TIM22 and TIM54, associated with the 70 kDa heterohexamer composed of TIM9 and TIM10 (or TIM8 and TIM13).
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).
messages: Mitochondrion inner membrane

284811:AGOS ABL109W
gene id: 284811:AGOS_ABL109W
uniprot id: Q75DY2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the flavokinase family.
messages: Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.
messages: Zinc or magnesium.

284811:AGOS ADR190W
gene id: 284811:AGOS_ADR190W
uniprot id: Q759T3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Homodimer.
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.

284811:AGOS ADL306C
gene id: 284811:AGOS_ADL306C
uniprot id: Q75B78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.
messages: Mitochondrion
messages: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.

284811:AGOS ACL199C
gene id: 284811:AGOS_ACL199C
uniprot id: Q75CW5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Does not seem to have protease activity as it lacks the zinc-binding site.
messages: Mitochondrion inner membrane

284811:AGOS ADR262C
gene id: 284811:AGOS_ADR262C
uniprot id: Q759L4
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

284811:AGOS AGL333W
gene id: 284811:AGOS_AGL333W
uniprot id: Q751N0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynein light intermediate chain DYN3 family.
messages: Component of the cytoplasmic dynein which acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle (By similarity).
messages: The cytoplasmic dynein is composed of at least two heavy chains and a number of intermediate and light chains.
messages: cytoskeleton

284811:AGOS AEL009C
gene id: 284811:AGOS_AEL009C
uniprot id: Q757M0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 2 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS AEL125C
gene id: 284811:AGOS_AEL125C
uniprot id: Q757Y5
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AER019C
gene id: 284811:AGOS_AER019C
uniprot id: Q757J4
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

284811:AGOS AFL232W
gene id: 284811:AGOS_AFL232W
uniprot id: Q755P5
names: Similarity
messages: Belongs to the syntaxin family.

284811:AGOS AAL020C
gene id: 284811:AGOS_AAL020C
uniprot id: Q75ET6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL27 family.
messages: Component of the large subunit of mitochondrial ribosome.
messages: Mitochondrion

284811:AGOS AEL235W
gene id: 284811:AGOS_AEL235W
uniprot id: Q758J7
names: Similarity
messages: Belongs to the GroES chaperonin family.

284811:AGOS AFL044W
gene id: 284811:AGOS_AFL044W
uniprot id: Q754W1
names: Similarity
messages: Belongs to the bystin family.

284811:AGOS ADR322W
gene id: 284811:AGOS_ADR322W
uniprot id: Q759F4
names: Similarity
messages: Belongs to the SUN family.

284811:AGOS ACL034W
gene id: 284811:AGOS_ACL034W
uniprot id: Q75CF4
names: Subcellular Location Annotation
messages: nucleolus

284811:AGOS AFL161C
gene id: 284811:AGOS_AFL161C
uniprot id: Q755I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GYP5 family.
messages: Cytoplasm
messages: GTPase-activating protein which accelerates the GTP hydrolysis rate of several GTPases. Involved in ER to Golgi trafficking and polarized exocytosis (By similarity).

284811:AGOS AFR421C
gene id: 284811:AGOS_AFR421C
uniprot id: Q753A3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YAE1 family.
messages: Cytoplasm
messages: May form a complex with LTO1.
messages: Nucleus
messages: The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.

284811:AGOS AGR350C
gene id: 284811:AGOS_AGR350C
uniprot id: Q74Z56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. Yeast FIT2A/YFT2 subfamily.
messages: Endoplasmic reticulum membrane
messages: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization). Involved in phospholipid biosynthesis.
messages: Membrane

284811:AGOS ABR177C
gene id: 284811:AGOS_ABR177C
uniprot id: Q75D46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Nucleus
messages: Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity).

284811:AGOS ABR010C
gene id: 284811:AGOS_ABR010C
uniprot id: Q75DL1
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

284811:AGOS ADR384W
gene id: 284811:AGOS_ADR384W
uniprot id: Q758Z3
names: Similarity
messages: Belongs to the cyclin family.

284811:AGOS AFL088W
gene id: 284811:AGOS_AFL088W
uniprot id: Q755B3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template. Involved in the regulation of transcription elongation (By similarity).
messages: nucleolus

284811:AGOS AFR241W
gene id: 284811:AGOS_AFR241W
uniprot id: Q753T5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

284811:AGOS AGR294C
gene id: 284811:AGOS_AGR294C
uniprot id: Q74ZA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Ran family.
messages: Found in a nuclear export complex with RanGTP, exportin and pre-miRNA (By similarity).
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity).
messages: Nucleus

284811:AGOS AFR295W
gene id: 284811:AGOS_AFR295W
uniprot id: Q753L7
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

284811:AGOS AFR262C
gene id: 284811:AGOS_AFR262C
uniprot id: Q753R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

284811:AGOS ACL105C
gene id: 284811:AGOS_ACL105C
uniprot id: Q75CM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SBE2 family.
messages: Golgi apparatus
messages: With SBE22, is involved in cell wall integrity and polarity processes like bud growth.

284811:AGOS ADR085W
gene id: 284811:AGOS_ADR085W
uniprot id: Q75AH4
names: Similarity
messages: Belongs to the biotin--protein ligase family.

284811:AGOS ADR103C
gene id: 284811:AGOS_ADR103C
uniprot id: Q75AH3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL41 family.

284811:AGOS ACR211W
gene id: 284811:AGOS_ACR211W
uniprot id: Q75BR0
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

284811:AGOS AER380C
gene id: 284811:AGOS_AER380C
uniprot id: Q755Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

284811:AGOS AER113W
gene id: 284811:AGOS_AER113W
uniprot id: Q757A0
names: Subcellular Location Annotation
messages: Cytoplasm

284811:AGOS ADL215W
gene id: 284811:AGOS_ADL215W
uniprot id: Q75AY5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

284811:AGOS ACR143W
gene id: 284811:AGOS_ACR143W
uniprot id: Q75BX8
names: Similarity
messages: Belongs to the peptidase A1 family.

284811:AGOS ADR345C
gene id: 284811:AGOS_ADR345C
uniprot id: Q759D2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM14 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1) (By similarity).
messages: Heterodimer with PAM16. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18 (By similarity).
messages: Mitochondrion inner membrane
messages: The J domain is essential for co-chaperone activity and mediates the heterodimerization with the J-like domain of PAM16.

284811:AGOS AGR349W
gene id: 284811:AGOS_AGR349W
uniprot id: Q74Z57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

284811:AGOS ACR063C
gene id: 284811:AGOS_ACR063C
uniprot id: Q75C54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS ADL197C
gene id: 284811:AGOS_ADL197C
uniprot id: Q75AW7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family. PFA3 subfamily.
messages: Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization (By similarity).
messages: The DHHC domain is required for palmitoyltransferase activity.
messages: Vacuole membrane

284811:AGOS AFR485C
gene id: 284811:AGOS_AFR485C
uniprot id: Q752T8
names: Similarity
messages: In the C-terminal section; belongs to the TrpB family.
messages: In the N-terminal section; belongs to the TrpA family.

284811:AGOS ABR153C
gene id: 284811:AGOS_ABR153C
uniprot id: Q75D70
names: Similarity
messages: Belongs to the yippee family.

284811:AGOS ABL119C
gene id: 284811:AGOS_ABL119C
uniprot id: Q75DZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AEP2 family.
messages: Binds to the 5'UTR of the OLI1 mRNA.
messages: Mitochondrion
messages: Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9.

284811:AGOS AFR605C
gene id: 284811:AGOS_AFR605C
uniprot id: Q752H9
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AER154C
gene id: 284811:AGOS_AER154C
uniprot id: Q756U8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

284811:AGOS AEL238C
gene id: 284811:AGOS_AEL238C
uniprot id: Q758K0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FPP/GGPP synthase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. May be involved in vesicle trafficking and protein sorting (By similarity).
messages: Cytoplasm

284811:AGOS ADL141W
gene id: 284811:AGOS_ADL141W
uniprot id: Q75AR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

284811:AGOS ADR212C
gene id: 284811:AGOS_ADR212C
uniprot id: Q759R1
names: Similarity
messages: Belongs to the RNase Z family.

284811:AGOS ABL132W
gene id: 284811:AGOS_ABL132W
uniprot id: Q75E05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

284811:AGOS AFR106C
gene id: 284811:AGOS_AFR106C
uniprot id: Q754G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

284811:AGOS AEL268W
gene id: 284811:AGOS_AEL268W
uniprot id: Q758V2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

284811:AGOS ABL189W
gene id: 284811:AGOS_ABL189W
uniprot id: Q75E59
names: Similarity
messages: Belongs to the AIM6 family.

284811:AGOS AFR468W
gene id: 284811:AGOS_AFR468W
uniprot id: Q752V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

284811:AGOS AGR127C
gene id: 284811:AGOS_AGR127C
uniprot id: Q74ZS1
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

284811:AGOS AER297C
gene id: 284811:AGOS_AER297C
uniprot id: Q756G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Histone acetyltransferase that acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation (By similarity). Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity). In addition to histone acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA) and is able to mediate histone crotonylation (By similarity).
messages: Nucleus

284811:AGOS AEL082W
gene id: 284811:AGOS_AEL082W
uniprot id: Q757U4
names: Similarity
messages: Belongs to the MNN1/MNT family.

284811:AGOS AFR546W
gene id: 284811:AGOS_AFR546W
uniprot id: Q752M8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

284811:AGOS AFR347C
gene id: 284811:AGOS_AFR347C
uniprot id: Q753G5
names: Similarity
messages: Belongs to the AHA1 family.

284811:AGOS ABL002C
gene id: 284811:AGOS_ABL002C
uniprot id: Q75DL9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

284811:AGOS AEL171C
gene id: 284811:AGOS_AEL171C
uniprot id: Q758C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Involved in vacuolar transport and vacuole pH homeostasis. Also required for cytokinesis (By similarity).
messages: Vacuole membrane

284811:AGOS AEL124W
gene id: 284811:AGOS_AEL124W
uniprot id: Q757Y4
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

284811:AGOS ADR255W
gene id: 284811:AGOS_ADR255W
uniprot id: Q759M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIP5 family.
messages: Cytoplasm
messages: May negatively regulate the SNF1 kinase.

284811:AGOS AFR194W
gene id: 284811:AGOS_AFR194W
uniprot id: Q753X8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

284811:AGOS AER051C
gene id: 284811:AGOS_AER051C
uniprot id: Q757G2
names: Subcellular Location Annotation
messages: nucleolus

284811:AGOS AFR016W
gene id: 284811:AGOS_AFR016W
uniprot id: Q754Q6
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

284811:AGOS AFR272W
gene id: 284811:AGOS_AFR272W
uniprot id: Q753P0
names: Similarity
messages: Belongs to the APC10 family.

284811:AGOS AEL017W
gene id: 284811:AGOS_AEL017W
uniprot id: Q757L7
names: Similarity
messages: Belongs to the SH3YL1 family.

284811:AGOS AER238C
gene id: 284811:AGOS_AER238C
uniprot id: Q756L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

284811:AGOS ABL031W
gene id: 284811:AGOS_ABL031W
uniprot id: Q75DP8
names: Function
names: Similarity
messages: Belongs to the MTC2 family.
messages: May be involved in telomere capping.

284811:AGOS AEL156W
gene id: 284811:AGOS_AEL156W
uniprot id: Q758A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasm
messages: Serine hydrolase involved in the detoxification of formaldehyde.

284811:AGOS AGR383W
gene id: 284811:AGOS_AGR383W
uniprot id: Q74Z23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.
messages: Mitochondrion inner membrane

284811:AGOS ADL295W
gene id: 284811:AGOS_ADL295W
uniprot id: Q75B67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

284811:AGOS AGR358W
gene id: 284811:AGOS_AGR358W
uniprot id: Q74Z48
names: Similarity
messages: In the C-terminal section; belongs to the NAD synthetase family.

284811:AGOS AAL143W
gene id: 284811:AGOS_AAL143W
uniprot id: Q75F71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer composed of 2 large adaptins (APL5 and APL6), a medium adaptin (APM3) and a small adaptin (APS3).
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity).

284811:AGOS AGR340W
gene id: 284811:AGOS_AGR340W
uniprot id: Q74Z66
names: Similarity
messages: Belongs to the LSM12 family.

284811:AGOS AGR198C
gene id: 284811:AGOS_AGR198C
uniprot id: Q74ZK2
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AGL222W
gene id: 284811:AGOS_AGL222W
uniprot id: Q751C8
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

284811:AGOS ADR189W
gene id: 284811:AGOS_ADR189W
uniprot id: Q759T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.

284811:AGOS ACR139C
gene id: 284811:AGOS_ACR139C
uniprot id: Q75BY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).

284811:AGOS ABL120W
gene id: 284811:AGOS_ABL120W
uniprot id: Q75DZ3
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

284811:AGOS ADR218W
gene id: 284811:AGOS_ADR218W
uniprot id: Q759Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: Nucleus
messages: Plays a central role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by protecting RAD21 and or REC8 from cleavage by ESP1/separase (By similarity).
messages: centromere

284811:AGOS ABL079C
gene id: 284811:AGOS_ABL079C
uniprot id: Q75DV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IML1 family.
messages: Vacuole membrane

284811:AGOS ACR199C
gene id: 284811:AGOS_ACR199C
uniprot id: Q75BS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC13 family.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution (By similarity).
messages: Endoplasmic reticulum membrane
messages: The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.
messages: nuclear pore complex

284811:AGOS ADR064C
gene id: 284811:AGOS_ADR064C
uniprot id: Q75A55
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

284811:AGOS AAL037C
gene id: 284811:AGOS_AAL037C
uniprot id: Q75EW5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPK1 type 1 family.
messages: Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.
messages: Nucleus
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

284811:AGOS AEL026C
gene id: 284811:AGOS_AEL026C
uniprot id: Q757N8
names: Similarity
messages: Belongs to the syntaxin family.

284811:AGOS ADR111W
gene id: 284811:AGOS_ADR111W
uniprot id: Q75A16
names: Similarity
messages: Belongs to the activator 1 small subunits family.

284811:AGOS AGL355W
gene id: 284811:AGOS_AGL355W
uniprot id: Q751P4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC22 family.
messages: Cytoplasm
messages: May be involved in pre-mRNA splicing.
messages: Nucleus

284811:AGOS ADL021W
gene id: 284811:AGOS_ADL021W
uniprot id: Q75AD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

284811:AGOS AFR567W
gene id: 284811:AGOS_AFR567W
uniprot id: Q752K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

284811:AGOS ADL171W
gene id: 284811:AGOS_ADL171W
uniprot id: Q75AU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

284811:AGOS ADR216W
gene id: 284811:AGOS_ADR216W
uniprot id: Q759Q7
names: Similarity
messages: Belongs to the nucleoporin Nup133 family.

284811:AGOS AER102W
gene id: 284811:AGOS_AER102W
uniprot id: Q757B1
names: Similarity
messages: Belongs to the DOCK family.

284811:AGOS AGL137W
gene id: 284811:AGOS_AGL137W
uniprot id: Q750S6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Forms part of complex II containing four subunits: a flavoprotein (FP), an iron-sulfur protein (IP) and a cytochrome b composed of a large and a small subunit.
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

284811:AGOS AGR080W
gene id: 284811:AGOS_AGR080W
uniprot id: Q74ZX8
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

284811:AGOS ABR230C
gene id: 284811:AGOS_ABR230C
uniprot id: Q75CZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS AEL086W
gene id: 284811:AGOS_AEL086W
uniprot id: Q757U8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

284811:AGOS ACL037W
gene id: 284811:AGOS_ACL037W
uniprot id: Q75CF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

284811:AGOS ADR294C
gene id: 284811:AGOS_ADR294C
uniprot id: Q759H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YSP2 family.
messages: Membrane

284811:AGOS ADL121W
gene id: 284811:AGOS_ADL121W
uniprot id: Q75AP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

284811:AGOS AER114W
gene id: 284811:AGOS_AER114W
uniprot id: Q756Z9
names: Similarity
messages: Belongs to the WD repeat coronin family.

284811:AGOS AAL089W
gene id: 284811:AGOS_AAL089W
uniprot id: Q75F17
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

284811:AGOS ABR130W
gene id: 284811:AGOS_ABR130W
uniprot id: Q75D94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX23 family.
messages: Mitochondrion intermembrane space
messages: Required for the assembly of cytochrome c oxidase.

284811:AGOS ADR080W
gene id: 284811:AGOS_ADR080W
uniprot id: Q75A39
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AGR320W
gene id: 284811:AGOS_AGR320W
uniprot id: Q74ZF8
names: Similarity
messages: Belongs to the eIF-2-alpha family.

284811:AGOS ADL277W
gene id: 284811:AGOS_ADL277W
uniprot id: Q75B54
names: Similarity
messages: Belongs to the NOC2 family.

284811:AGOS AFL172W
gene id: 284811:AGOS_AFL172W
uniprot id: Q755J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBP1 family.
messages: Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication. Connects the central plaque of the SPB with the half-bridge. Required for proper localization of CDC5 at the SPB and for proper M-phase progression (By similarity).
messages: Homodimer.
messages: spindle pole body

284811:AGOS ABL204W
gene id: 284811:AGOS_ABL204W
uniprot id: Q75E86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm
messages: Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.
messages: Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.
messages: Mitochondrion
messages: The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.

284811:AGOS AFR391W
gene id: 284811:AGOS_AFR391W
uniprot id: Q753C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM31/MDM32 family.
messages: Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures (By similarity).
messages: Mitochondrion inner membrane

284811:AGOS AGR194W
gene id: 284811:AGOS_AGR194W
uniprot id: Q74ZK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

284811:AGOS AGR182C
gene id: 284811:AGOS_AGR182C
uniprot id: Q74ZL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCC1 family.
messages: Membrane

284811:AGOS AAL072C
gene id: 284811:AGOS_AAL072C
uniprot id: Q75F00
names: Similarity
messages: Belongs to the RNR ribonuclease family.

284811:AGOS ACR160C
gene id: 284811:AGOS_ACR160C
uniprot id: Q75BW1
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

284811:AGOS ACR239C
gene id: 284811:AGOS_ACR239C
uniprot id: Q75BN2
names: Similarity
messages: Belongs to the PP2C family.

284811:AGOS ACR061C
gene id: 284811:AGOS_ACR061C
uniprot id: Q75C55
names: Similarity
messages: Belongs to the NUP186/NUP192/NUP205 family.

284811:AGOS AAR037W
gene id: 284811:AGOS_AAR037W
uniprot id: Q75EP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

284811:AGOS AGR316C
gene id: 284811:AGOS_AGR316C
uniprot id: Q74Z87
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

284811:AGOS AER334C
gene id: 284811:AGOS_AER334C
uniprot id: Q756D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-Z subfamily.
messages: Cytoplasm

284811:AGOS AFL075W
gene id: 284811:AGOS_AFL075W
uniprot id: Q755A0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDC1 family.
messages: Component of the checkpoint clamp complex composed of DDC1, MEC3 and RAD17.
messages: Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.
messages: Cytoplasm
messages: Nucleus

284811:AGOS AGR042W
gene id: 284811:AGOS_AGR042W
uniprot id: Q750B5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX4 family.
messages: Forms a heterodimer with SLX1.
messages: Nucleus
messages: Phosphorylated in response to DNA damage.
messages: Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (By similarity).

284811:AGOS AFR156W
gene id: 284811:AGOS_AFR156W
uniprot id: Q754B4
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AAR156C
gene id: 284811:AGOS_AAR156C
uniprot id: Q75EB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation.
messages: Cytoplasm
messages: Nucleus

284811:AGOS AFR169W
gene id: 284811:AGOS_AFR169W
uniprot id: Q754A3
names: Similarity
messages: Belongs to the GCN1 family.

284811:AGOS AFL085C
gene id: 284811:AGOS_AFL085C
uniprot id: Q755B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

284811:AGOS ABL162C
gene id: 284811:AGOS_ABL162C
uniprot id: Q75E32
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Core regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).
messages: Nucleus
messages: Regulatory subunit 3 (R3) of the histone H2A phosphatase complex (HTP-C) consisting of PPH3, PSY2 and PSY4.

284811:AGOS AGL069C
gene id: 284811:AGOS_AGL069C
uniprot id: Q750M5
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR239W
gene id: 284811:AGOS_AFR239W
uniprot id: Q753T7
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

284811:AGOS AMI004W
gene id: 284811:AGOS_AMI004W
uniprot id: Q75G41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Essential for mitochondrial protein synthesis and required for the maturation of small ribosomal subunits.
messages: Mitochondrion

284811:AGOS AGL001W
gene id: 284811:AGOS_AGL001W
uniprot id: Q750F5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
messages: Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail (By similarity).
messages: Cytoplasm
messages: Nucleus

284811:AGOS AFL022W
gene id: 284811:AGOS_AFL022W
uniprot id: Q754U3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: actin patch

284811:AGOS AFL202C
gene id: 284811:AGOS_AFL202C
uniprot id: Q755L6
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AGL186C
gene id: 284811:AGOS_AGL186C
uniprot id: Q750X5
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

284811:AGOS AFR171W
gene id: 284811:AGOS_AFR171W
uniprot id: Q754A1
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AAL043C
gene id: 284811:AGOS_AAL043C
uniprot id: Q75EX1
names: Similarity
messages: Belongs to the heat shock protein 70 family.

284811:AGOS AFR081C
gene id: 284811:AGOS_AFR081C
uniprot id: Q754J3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERT1/acuK family.
messages: Nucleus
messages: Transcription factor which regulates nonfermentable carbon utilization.

284811:AGOS ABL170C
gene id: 284811:AGOS_ABL170C
uniprot id: Q75E40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS ABR109C
gene id: 284811:AGOS_ABR109C
uniprot id: Q75DB7
names: Function
names: Similarity
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

284811:AGOS ACR148W
gene id: 284811:AGOS_ACR148W
uniprot id: Q75BX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM44 family.
messages: Bud neck

284811:AGOS ADR025W
gene id: 284811:AGOS_ADR025W
uniprot id: Q75A93
names: Similarity
messages: Belongs to the TOP6A family.

284811:AGOS AEL215C
gene id: 284811:AGOS_AEL215C
uniprot id: Q758H7
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

284811:AGOS AFR395C
gene id: 284811:AGOS_AFR395C
uniprot id: Q753C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity).
messages: Belongs to the glycosyltransferase 22 family. PIGZ subfamily.
messages: Endoplasmic reticulum membrane

284811:AGOS AGL274W
gene id: 284811:AGOS_AGL274W
uniprot id: Q751I0
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

284811:AGOS AFR352C
gene id: 284811:AGOS_AFR352C
uniprot id: Q753R1
names: Similarity
messages: Belongs to the heat shock protein 70 family.

284811:AGOS AFR252C
gene id: 284811:AGOS_AFR252C
uniprot id: Q753S4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

284811:AGOS ADL276W
gene id: 284811:AGOS_ADL276W
uniprot id: Q75B53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

284811:AGOS ABR060W
gene id: 284811:AGOS_ABR060W
uniprot id: Q75DG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 76 family.
messages: Cell membrane
messages: Required for normal synthesis of the cell wall.
messages: cell wall

284811:AGOS AFR387C
gene id: 284811:AGOS_AFR387C
uniprot id: Q753C9
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

284811:AGOS ABR160C
gene id: 284811:AGOS_ABR160C
uniprot id: Q75D63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

284811:AGOS AER186C
gene id: 284811:AGOS_AER186C
uniprot id: Q756R8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEK2 family.
messages: Binds RNA.
messages: Cytoplasm
messages: Nucleus
messages: P-body
messages: RNA-binding protein involved in the correct localization of transcripts in the cell. RNA localization is a widespread mechanism for achieving localized protein synthesis. Involved in structural and functional organization of telomeric chromatin and regulates silencing at the HMR locus (By similarity).
messages: telomere

284811:AGOS AFL123W
gene id: 284811:AGOS_AFL123W
uniprot id: Q755E6
names: Similarity
messages: Belongs to the SELO family.

284811:AGOS AAL015W
gene id: 284811:AGOS_AAL015W
uniprot id: Q75EV1
names: Similarity
messages: Belongs to the DCC1 family.

284811:AGOS AFR542W
gene id: 284811:AGOS_AFR542W
uniprot id: Q752N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

284811:AGOS ADL304W
gene id: 284811:AGOS_ADL304W
uniprot id: Q75B76
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

284811:AGOS AFR698C
gene id: 284811:AGOS_AFR698C
uniprot id: Q751X7
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADR407C
gene id: 284811:AGOS_ADR407C
uniprot id: Q758X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

284811:AGOS ACL097C
gene id: 284811:AGOS_ACL097C
uniprot id: Q75CL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Mitochondrion inner membrane

284811:AGOS ABL032C
gene id: 284811:AGOS_ABL032C
uniprot id: Q75DP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

284811:AGOS ADR250C
gene id: 284811:AGOS_ADR250C
uniprot id: Q759M6
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AGR183C
gene id: 284811:AGOS_AGR183C
uniprot id: Q74ZL5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by GCN5 to form H2BK11ac and H2BK16ac. H2BK16ac can also be formed by ESA1. Acetylation of N-terminal lysines and particularly formation of H2BK11acK16ac has a positive effect on transcription (By similarity).
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitinated by the UBC2-BRE1 complex to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and H3K79me formation. H2BK123ub1 also modulates the formation of double-strand breaks during meiosis and is a prerequisite for DNA-damage checkpoint activation (By similarity).
messages: Nucleus
messages: Phosphorylated by STE20 to form H2BS10ph during progression through meiotic prophase. May be correlated with chromosome condensation (By similarity).
messages: Sumoylation to form H2BK6su and probably also H2BK16su or H2BK17su, occurs preferentially near the telomeres and represses gene transcription.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2BK6ac = acetylated Lys-7; H2BK6su = sumoylated Lys-7; H2BS10ph = phosphorylated Ser-11; H2BK11ac = acetylated Lys-12; H2BK16ac = acetylated Lys-17; H2BK16su = sumoylated Lys-17; H2BK17su = sumoylated Lys-18; H2BK123ub1 = monoubiquitinated Lys-125.

284811:AGOS AEL273C
gene id: 284811:AGOS_AEL273C
uniprot id: Q758M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AGL318W
gene id: 284811:AGOS_AGL318W
uniprot id: Q751R1
names: Similarity
messages: Belongs to the VPS25 family.

284811:AGOS AEL315W
gene id: 284811:AGOS_AEL315W
uniprot id: Q758R8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex SPC34 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
messages: Nucleus
messages: The DASH complex oligomerizes to form rings that encircle the microtubules.
messages: kinetochore
messages: spindle

284811:AGOS AEL053C
gene id: 284811:AGOS_AEL053C
uniprot id: Q757R5
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ABR247W
gene id: 284811:AGOS_ABR247W
uniprot id: Q75DB2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

284811:AGOS ACR215C
gene id: 284811:AGOS_ACR215C
uniprot id: Q75BQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Cytoplasm
messages: Homotetramer.
messages: Interconversion of serine and glycine.

284811:AGOS AER449W
gene id: 284811:AGOS_AER449W
uniprot id: Q755R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with mRNPs.
messages: Belongs to the YRA1 family.
messages: Involved in export of poly(A) mRNAs from the nucleus. Recruited to the coding sequences as well as poly-A sites of active genes (By similarity).
messages: Nucleus

284811:AGOS ADR289C
gene id: 284811:AGOS_ADR289C
uniprot id: Q759I8
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ACR036C
gene id: 284811:AGOS_ACR036C
uniprot id: Q75C80
names: Function
names: Similarity
messages: Belongs to the FYV8 family.
messages: Involved in the resistance to unfolded protein response (UPR)-inducing agents.

284811:AGOS AFL065C
gene id: 284811:AGOS_AFL065C
uniprot id: Q754Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAD1 family.
messages: Central component of the spindle assembly checkpoint.
messages: Nucleus

284811:AGOS AFR428C
gene id: 284811:AGOS_AFR428C
uniprot id: Q753Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

284811:AGOS AEL247W
gene id: 284811:AGOS_AEL247W
uniprot id: Q758K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

284811:AGOS ADR363C
gene id: 284811:AGOS_ADR363C
uniprot id: Q759B4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm
messages: Mitochondrion
messages: Monomer.

284811:AGOS ACL080W
gene id: 284811:AGOS_ACL080W
uniprot id: Q75CJ9
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADR056W
gene id: 284811:AGOS_ADR056W
uniprot id: Q75A62
names: Similarity
messages: Belongs to the PGA52 family.

284811:AGOS AER190W
gene id: 284811:AGOS_AER190W
uniprot id: Q756R4
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AAR134W
gene id: 284811:AGOS_AAR134W
uniprot id: Q75EE7
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

284811:AGOS AAR018W
gene id: 284811:AGOS_AAR018W
uniprot id: Q75ER1
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

284811:AGOS AEL256C
gene id: 284811:AGOS_AEL256C
uniprot id: Q758L7
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ACR079W
gene id: 284811:AGOS_ACR079W
uniprot id: Q75C38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0057 (PMP3) family.
messages: Cell membrane
messages: Plays a role in the regulation of membrane potential. Could mediate a proton leak (By similarity).

284811:AGOS AFR204W
gene id: 284811:AGOS_AFR204W
uniprot id: Q753W8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex HSK3 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
messages: Nucleus
messages: The DASH complex oligomerizes to form rings that encircle the microtubules.
messages: kinetochore
messages: spindle

284811:AGOS ACR136C
gene id: 284811:AGOS_ACR136C
uniprot id: Q75BY4
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

284811:AGOS ACR044C
gene id: 284811:AGOS_ACR044C
uniprot id: Q75C72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

284811:AGOS AGR162C
gene id: 284811:AGOS_AGR162C
uniprot id: Q74ZN6
names: Similarity
messages: Belongs to the XPC family.

284811:AGOS ADR337C
gene id: 284811:AGOS_ADR337C
uniprot id: Q759E0
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AER251W
gene id: 284811:AGOS_AER251W
uniprot id: Q756K3
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a cullin-RING ligase (CRL)-like complex composed of at least the cullin RTT101, a linker protein MMS1, and the potential substrate receptor ESC2.
messages: Cytoplasm
messages: May be a substrate targeting component of a cullin-RING-based E3 ubiquitin-protein ligase complex RTT101(MMS1-ESC2). Involved in HMR and telomere silencing via the recruitment or stabilizing of the SIR (silent information regulators) complex (By similarity).
messages: Nucleus
messages: The 2 SUMO-like regions, although related to ubiquitin domains lack the conserved acceptor Gly residue in position 456.

284811:AGOS ABL101C
gene id: 284811:AGOS_ABL101C
uniprot id: Q75DX4
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

284811:AGOS AGR157C
gene id: 284811:AGOS_AGR157C
uniprot id: Q74ZP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AGR118W
gene id: 284811:AGOS_AGR118W
uniprot id: Q74ZT0
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

284811:AGOS ADL134W
gene id: 284811:AGOS_ADL134W
uniprot id: Q75AQ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Cytoplasmic vesicle membrane
messages: Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.
messages: May contain a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.
messages: Vacuole membrane

284811:AGOS AFL171W
gene id: 284811:AGOS_AFL171W
uniprot id: Q755J4
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ADR268W
gene id: 284811:AGOS_ADR268W
uniprot id: Q759K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

284811:AGOS ADL116C
gene id: 284811:AGOS_ADL116C
uniprot id: Q75AN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

284811:AGOS AFL060W
gene id: 284811:AGOS_AFL060W
uniprot id: Q754X6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NBP35 and two labile, bridging clusters between subunits of the NBP35-CFD1 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.
messages: Cytoplasm
messages: Heterotetramer of 2 NBP35 and 2 CFD1 chains.
messages: Nucleus

284811:AGOS AAR113W
gene id: 284811:AGOS_AAR113W
uniprot id: Q75EG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Probably involved in transport through the plasma membrane.

284811:AGOS AFR369W
gene id: 284811:AGOS_AFR369W
uniprot id: Q753E7
names: Similarity
messages: Belongs to the thymidylate kinase family.

284811:AGOS AFL001W
gene id: 284811:AGOS_AFL001W
uniprot id: Q754S2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.

284811:AGOS AEL253W
gene id: 284811:AGOS_AEL253W
uniprot id: Q758L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS ADL391C
gene id: 284811:AGOS_ADL391C
uniprot id: Q75BG3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

284811:AGOS AFL049C
gene id: 284811:AGOS_AFL049C
uniprot id: Q754W6
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AGR240W
gene id: 284811:AGOS_AGR240W
uniprot id: Q74ZG7
names: Similarity
messages: Belongs to the peptidase A1 family.

284811:AGOS AFR648W
gene id: 284811:AGOS_AFR648W
uniprot id: Q752C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Mitochondrion inner membrane

284811:AGOS AGR356W
gene id: 284811:AGOS_AGR356W
uniprot id: Q74Z50
names: Similarity
messages: Belongs to the OSBP family.

284811:AGOS AFR209W
gene id: 284811:AGOS_AFR209W
uniprot id: Q753W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A component of the endosomal sorting required for transport complex III (ESCRT-III).
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity).

284811:AGOS AAR012C
gene id: 284811:AGOS_AAR012C
uniprot id: Q75ER7
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

284811:AGOS ABR147C
gene id: 284811:AGOS_ABR147C
uniprot id: Q75D77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP4R2 family.
messages: Nucleus
messages: Regulatory subunit (R2) of the histone H2A phosphatase complex (HTP-C) consisting of PPH3, PSY2 and PSY4.
messages: Regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).

284811:AGOS ABL202W
gene id: 284811:AGOS_ABL202W
uniprot id: Q75E72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 16 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS AGL245C
gene id: 284811:AGOS_AGL245C
uniprot id: Q751F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAC-beta family.
messages: Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1 (By similarity).

284811:AGOS AFR481W
gene id: 284811:AGOS_AFR481W
uniprot id: Q752U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CGR1 family.
messages: Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.
messages: nucleolus

284811:AGOS AGL321W
gene id: 284811:AGOS_AGL321W
uniprot id: Q751L8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.

284811:AGOS AEL300C
gene id: 284811:AGOS_AEL300C
uniprot id: Q758Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

284811:AGOS ADR102W
gene id: 284811:AGOS_ADR102W
uniprot id: Q9UVJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
messages: Endomembrane system
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

284811:AGOS ADL138C
gene id: 284811:AGOS_ADL138C
uniprot id: Q75AQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Endoplasmic reticulum membrane

284811:AGOS ABL117C
gene id: 284811:AGOS_ABL117C
uniprot id: Q75DZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku70 family.
messages: Nucleus
messages: telomere

284811:AGOS ADL300W
gene id: 284811:AGOS_ADL300W
uniprot id: Q75B72
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AER192W
gene id: 284811:AGOS_AER192W
uniprot id: Q756R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

284811:AGOS AFL105C
gene id: 284811:AGOS_AFL105C
uniprot id: Q755C8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Binds 1 zinc ion per subunit.
messages: Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.
messages: Nucleus

284811:AGOS AEL087C
gene id: 284811:AGOS_AEL087C
uniprot id: Q757U9
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

284811:AGOS AER041W
gene id: 284811:AGOS_AER041W
uniprot id: Q757H2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PITP family.
messages: Binds phosphatidylinositol (PtdIns).
messages: Cytoplasm
messages: Endosome
messages: Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. May also regulate post-Golgi membrane-trafficking events and have a role resistance to oxidative stress (By similarity).

284811:AGOS AGR372W
gene id: 284811:AGOS_AGR372W
uniprot id: Q74Z34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains.
messages: Endoplasmic reticulum membrane

284811:AGOS AFR738C
gene id: 284811:AGOS_AFR738C
uniprot id: Q751T7
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ACL073W
gene id: 284811:AGOS_ACL073W
uniprot id: Q75CJ2
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AGL342C
gene id: 284811:AGOS_AGL342C
uniprot id: Q751R3
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

284811:AGOS AEL118C
gene id: 284811:AGOS_AEL118C
uniprot id: Q757X8
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NPR/HAL subfamily. HAL5 sub-subfamily.

284811:AGOS ACL189C
gene id: 284811:AGOS_ACL189C
uniprot id: Q75CV5
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AEL313C
gene id: 284811:AGOS_AEL313C
uniprot id: Q758R6
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B family.

284811:AGOS AGL142C
gene id: 284811:AGOS_AGL142C
uniprot id: Q750T1
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AAL170W
gene id: 284811:AGOS_AAL170W
uniprot id: Q75F86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

284811:AGOS AFR141C
gene id: 284811:AGOS_AFR141C
uniprot id: Q754C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
messages: Interacts with EME1.
messages: Nucleus

284811:AGOS AFL235W
gene id: 284811:AGOS_AFL235W
uniprot id: Q755P8
names: Similarity
messages: Belongs to the MNN1/MNT family.

284811:AGOS ADR254W
gene id: 284811:AGOS_ADR254W
uniprot id: Q759M2
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

284811:AGOS AER421W
gene id: 284811:AGOS_AER421W
uniprot id: Q755U7
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

284811:AGOS AAR119W
gene id: 284811:AGOS_AAR119W
uniprot id: Q75EG2
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

284811:AGOS ADR267W
gene id: 284811:AGOS_ADR267W
uniprot id: Q759K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSW5 family.
messages: Involved in spore wall assembly.
messages: Membrane

284811:AGOS AER085C
gene id: 284811:AGOS_AER085C
uniprot id: Q757C8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the fungal fatty acid synthetase subunit beta family.
messages: Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.
messages: [Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).

284811:AGOS AER283W
gene id: 284811:AGOS_AER283W
uniprot id: Q756H8
names: Similarity
messages: Belongs to the PPase family.

284811:AGOS ADR090W
gene id: 284811:AGOS_ADR090W
uniprot id: Q75A30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC31 family.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
messages: Endoplasmic reticulum membrane
messages: The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity).

284811:AGOS ABL006C
gene id: 284811:AGOS_ABL006C
uniprot id: Q75DM3
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

284811:AGOS ACR224C
gene id: 284811:AGOS_ACR224C
uniprot id: Q75BP7
names: Function
names: Similarity
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

284811:AGOS ACR265C
gene id: 284811:AGOS_ACR265C
uniprot id: Q75BK6
names: Similarity
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.

284811:AGOS AGR303W
gene id: 284811:AGOS_AGR303W
uniprot id: Q74ZA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Nucleus
messages: Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity).

284811:AGOS AER341W
gene id: 284811:AGOS_AER341W
uniprot id: Q756C6
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

284811:AGOS AFR427W
gene id: 284811:AGOS_AFR427W
uniprot id: Q753Q7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Component of the 20S proteasome chaperone.
messages: Involved in 20S proteasome assembly.

284811:AGOS AFR575C
gene id: 284811:AGOS_AFR575C
uniprot id: Q752J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

284811:AGOS AEL153W
gene id: 284811:AGOS_AEL153W
uniprot id: Q758A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat UTP18 family.
messages: nucleolus

284811:AGOS AAL099C
gene id: 284811:AGOS_AAL099C
uniprot id: Q75F27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

284811:AGOS ADL327W
gene id: 284811:AGOS_ADL327W
uniprot id: Q75BG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaJ family.
messages: Mitochondrion membrane
messages: Probable chaperone.

284811:AGOS ABL061C
gene id: 284811:AGOS_ABL061C
uniprot id: Q75E84
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.

284811:AGOS AAL001W
gene id: 284811:AGOS_AAL001W
uniprot id: Q75ES9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.

284811:AGOS AGL032C
gene id: 284811:AGOS_AGL032C
uniprot id: Q750I3
names: Similarity
messages: Belongs to the peptidase M24B family.

284811:AGOS ABR154C
gene id: 284811:AGOS_ABR154C
uniprot id: Q75D69
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR714W
gene id: 284811:AGOS_AFR714W
uniprot id: Q751W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG22 family.
messages: Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity).
messages: Vacuole membrane

284811:AGOS ABR044C
gene id: 284811:AGOS_ABR044C
uniprot id: Q75DI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LU7TM family.
messages: Membrane

284811:AGOS ADR154W
gene id: 284811:AGOS_ADR154W
uniprot id: Q759W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS ADL396W
gene id: 284811:AGOS_ADL396W
uniprot id: Q75BF8
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

284811:AGOS AGR375W
gene id: 284811:AGOS_AGR375W
uniprot id: Q74Z31
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

284811:AGOS AFR108W
gene id: 284811:AGOS_AFR108W
uniprot id: Q754G2
names: Function
names: Similarity
messages: Belongs to the arrestin family. PalF/RIM8 subfamily.
messages: Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.

284811:AGOS AGR048C
gene id: 284811:AGOS_AGR048C
uniprot id: Q750A9
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by tyrosine and threonine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
messages: Cytoplasm
messages: Dually phosphorylated on Thr-174 and Tyr-176, which activates the enzyme.
messages: Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes (By similarity).
messages: Nucleus
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

284811:AGOS ADR178W
gene id: 284811:AGOS_ADR178W
uniprot id: Q759U5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

284811:AGOS AGL068W
gene id: 284811:AGOS_AGL068W
uniprot id: Q750Z9
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

284811:AGOS ACL166W
gene id: 284811:AGOS_ACL166W
uniprot id: Q75CT5
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

284811:AGOS ADL101C
gene id: 284811:AGOS_ADL101C
uniprot id: Q75AM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton

284811:AGOS ABR248W
gene id: 284811:AGOS_ABR248W
uniprot id: Q75DB1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

284811:AGOS ADR315W
gene id: 284811:AGOS_ADR315W
uniprot id: Q759G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Membrane

284811:AGOS AAL140C
gene id: 284811:AGOS_AAL140C
uniprot id: Q75F68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: nucleolus

284811:AGOS ADL369C
gene id: 284811:AGOS_ADL369C
uniprot id: Q75BD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRL1/IGF2R family.
messages: Endosome membrane
messages: Sorting receptor involved in the transport of vacuolar enzymes from the Golgi complex to the vacuole.
messages: trans-Golgi network membrane

284811:AGOS ACR176C
gene id: 284811:AGOS_ACR176C
uniprot id: Q75BU5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: G proteins are composed of 3 units, alpha, beta and gamma.
messages: Membrane

284811:AGOS AEL192W
gene id: 284811:AGOS_AEL192W
uniprot id: Q758F4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.

284811:AGOS ABL141C
gene id: 284811:AGOS_ABL141C
uniprot id: Q75E14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat IPI3/WDR18 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
messages: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.
messages: Nucleus

284811:AGOS AMI002W
gene id: 284811:AGOS_AMI002W
uniprot id: P62514
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 2 heme A groups non-covalently per subunit.
messages: Binds a copper B center.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

284811:AGOS AGR338C
gene id: 284811:AGOS_AGR338C
uniprot id: Q74Z68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

284811:AGOS AFR037W
gene id: 284811:AGOS_AFR037W
uniprot id: Q754N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

284811:AGOS AFR344C
gene id: 284811:AGOS_AFR344C
uniprot id: Q753G8
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AAR141W
gene id: 284811:AGOS_AAR141W
uniprot id: Q75EE0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with TAH18. Interacts with MIA40.
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

284811:AGOS ADL318C
gene id: 284811:AGOS_ADL318C
uniprot id: Q75B88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EME1/MMS4 family.
messages: Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
messages: Interacts with MUS81.
messages: Nucleus

284811:AGOS ABL197C
gene id: 284811:AGOS_ABL197C
uniprot id: Q75E67
names: Function
names: Similarity
names: Subunit
messages: As part of the CRL3 E3 ubiquitin ligase complex; polyubiquitylates monoubiquitylated RNA polymerase II subunit RPO21 to trigger its proteolysis; plays a role in global genomic repair.
messages: Belongs to the ELA1 family.
messages: Heterodimer with ELC1. Component of a CRL3 E3 ubiquitin ligase complex consisting of a cullin, the linker protein ELC1, the substrate receptor ELA1, and a RING protein. Interacts with the large RNA polymerase II subunit RPO21 in a manner dependent on DEF1.

284811:AGOS ABR162W
gene id: 284811:AGOS_ABR162W
uniprot id: Q75D61
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AEL039W
gene id: 284811:AGOS_AEL039W
uniprot id: Q757Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

284811:AGOS ACR118W
gene id: 284811:AGOS_ACR118W
uniprot id: Q75C01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of SSC1 to substrate proteins (By similarity).
messages: Mitochondrion matrix

284811:AGOS AFR679C
gene id: 284811:AGOS_AFR679C
uniprot id: Q751Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.
messages: Nucleus
messages: kinetochore

284811:AGOS AER290C
gene id: 284811:AGOS_AER290C
uniprot id: Q756H6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

284811:AGOS ABL191W
gene id: 284811:AGOS_ABL191W
uniprot id: Q75E61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine. ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components. ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
messages: Cytoplasm
messages: Nucleus
messages: Preautophagosomal structure

284811:AGOS AGL257W
gene id: 284811:AGOS_AGL257W
uniprot id: Q751G3
names: Similarity
messages: Belongs to the GST superfamily.

284811:AGOS ACL172C
gene id: 284811:AGOS_ACL172C
uniprot id: Q75CU1
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AGR197C
gene id: 284811:AGOS_AGR197C
uniprot id: Q74ZK3
names: PTM
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.
messages: Phosphorylated.

284811:AGOS AER445C
gene id: 284811:AGOS_AER445C
uniprot id: Q755S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

284811:AGOS AER344W
gene id: 284811:AGOS_AER344W
uniprot id: Q756C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CEF1 family.
messages: Cytoplasm
messages: Involved in mRNA splicing and cell cycle control.
messages: Nucleus

284811:AGOS AGR074C
gene id: 284811:AGOS_AGR074C
uniprot id: Q74ZY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the midasin family.
messages: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.
messages: nucleolus
messages: nucleoplasm

284811:AGOS AAL146W
gene id: 284811:AGOS_AAL146W
uniprot id: Q75F74
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

284811:AGOS AFR172C
gene id: 284811:AGOS_AFR172C
uniprot id: Q754A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

284811:AGOS AFR446W
gene id: 284811:AGOS_AFR446W
uniprot id: Q752X7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Component of the GSE complex.
messages: GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.

284811:AGOS ABR245C
gene id: 284811:AGOS_ABR245C
uniprot id: Q75CX7
names: Similarity
messages: Belongs to the MNN1/MNT family.

284811:AGOS AFL053W
gene id: 284811:AGOS_AFL053W
uniprot id: Q754W9
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

284811:AGOS ABL086C
gene id: 284811:AGOS_ABL086C
uniprot id: Q75DV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGM101 family.
messages: Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome. Binds to DNA (By similarity).
messages: mitochondrion nucleoid

284811:AGOS AGL159W
gene id: 284811:AGOS_AGL159W
uniprot id: Q750U8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat TRM82 family.
messages: Forms a heterodimer with the catalytic subunit TRM8.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

284811:AGOS AER117W
gene id: 284811:AGOS_AER117W
uniprot id: Q756Z6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

284811:AGOS ABL175C
gene id: 284811:AGOS_ABL175C
uniprot id: Q75E45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRG9 family.
messages: Mitochondrion
messages: Required for respiratory activity and maintenance and expression of the mitochondrial genome.

284811:AGOS AER150W
gene id: 284811:AGOS_AER150W
uniprot id: Q756V1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.
messages: Inhibited by both FK506 and rapamycin.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
messages: nucleolus

284811:AGOS AGL144C
gene id: 284811:AGOS_AGL144C
uniprot id: Q750T3
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

284811:AGOS AAR053W
gene id: 284811:AGOS_AAR053W
uniprot id: Q75EM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 48 family.
messages: Membrane

284811:AGOS ADR139C
gene id: 284811:AGOS_ADR139C
uniprot id: Q759Y4
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

284811:AGOS AGR333C
gene id: 284811:AGOS_AGR333C
uniprot id: Q74Z73
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
messages: Associates in the nucleolus with the 60S and pre-60S ribosomal subunits.
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

284811:AGOS AFR463C
gene id: 284811:AGOS_AFR463C
uniprot id: Q752W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

284811:AGOS AAL034C
gene id: 284811:AGOS_AAL034C
uniprot id: Q75EW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

284811:AGOS ADL287C
gene id: 284811:AGOS_ADL287C
uniprot id: Q75B59
names: Cofactor
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Reduced FMN (FMNH(2)).

284811:AGOS AGL065C
gene id: 284811:AGOS_AGL065C
uniprot id: Q750M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS AEL122W
gene id: 284811:AGOS_AEL122W
uniprot id: Q757Y2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

284811:AGOS ACR103C
gene id: 284811:AGOS_ACR103C
uniprot id: Q75C14
names: Similarity
messages: Belongs to the peptidase S9B family.

284811:AGOS AFR200W
gene id: 284811:AGOS_AFR200W
uniprot id: Q753X2
names: Function
names: Similarity
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.

284811:AGOS ADR078C
gene id: 284811:AGOS_ADR078C
uniprot id: Q75A41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 16 family. CRR1 subfamily.
messages: Spore specific glycosidase involved in spore wall assembly during sporulation. May be involved in copper import (By similarity).
messages: Spore wall

284811:AGOS AGR122C
gene id: 284811:AGOS_AGR122C
uniprot id: Q74ZS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN (By similarity).
messages: Cytoplasm
messages: Nucleus

284811:AGOS ADR359W
gene id: 284811:AGOS_ADR359W
uniprot id: Q759B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.
messages: Homopentamer. Forms homooligomers. Interacts with MFM1.
messages: Mitochondrion inner membrane

284811:AGOS AGL303W
gene id: 284811:AGOS_AGL303W
uniprot id: Q751Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.

284811:AGOS ABL080W
gene id: 284811:AGOS_ABL080W
uniprot id: Q75DV3
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

284811:AGOS AGR328C
gene id: 284811:AGOS_AGR328C
uniprot id: Q74Z78
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ABL188W
gene id: 284811:AGOS_ABL188W
uniprot id: Q75E58
names: Similarity
messages: Belongs to the AIM6 family.

284811:AGOS ADL308C
gene id: 284811:AGOS_ADL308C
uniprot id: Q75B80
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

284811:AGOS AGR163W
gene id: 284811:AGOS_AGR163W
uniprot id: Q74ZN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Tetramer of two alpha and two beta subunits.

284811:AGOS AGL351W
gene id: 284811:AGOS_AGL351W
uniprot id: Q751S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

284811:AGOS ADL096W
gene id: 284811:AGOS_ADL096W
uniprot id: Q75AL9
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADR220W
gene id: 284811:AGOS_ADR220W
uniprot id: Q759Q3
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AGL231W
gene id: 284811:AGOS_AGL231W
uniprot id: Q751D7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
messages: Mitochondrion inner membrane

284811:AGOS ABL004W
gene id: 284811:AGOS_ABL004W
uniprot id: Q75DM1
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

284811:AGOS ADR277C
gene id: 284811:AGOS_ADR277C
uniprot id: Q759K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP14 family.
messages: Cytoplasm

284811:AGOS ABR218C
gene id: 284811:AGOS_ABR218C
uniprot id: Q75D04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YEL1 family.
messages: Bud neck
messages: Bud tip
messages: Cell membrane
messages: Cytoplasm
messages: Guanine nucleotide exchange factor for ARF3 required for localization of ARF3 to the bud neck and tip and involved in actin patch polarization.

284811:AGOS ADL003C
gene id: 284811:AGOS_ADL003C
uniprot id: Q75AC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

284811:AGOS ACR147C
gene id: 284811:AGOS_ACR147C
uniprot id: Q75BX4
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

284811:AGOS AAL115W
gene id: 284811:AGOS_AAL115W
uniprot id: Q75F43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Mitochondrion membrane

284811:AGOS AFR558C
gene id: 284811:AGOS_AFR558C
uniprot id: P62507
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Component of the large subunit of mitochondrial ribosome.
messages: Mitochondrion

284811:AGOS AGR213C
gene id: 284811:AGOS_AGR213C
uniprot id: Q74ZI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

284811:AGOS AGR133C
gene id: 284811:AGOS_AGR133C
uniprot id: Q74ZR5
names: Similarity
messages: Belongs to the SCC4/mau-2 family.

284811:AGOS AAL042W
gene id: 284811:AGOS_AAL042W
uniprot id: Q75EX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

284811:AGOS AGL077W
gene id: 284811:AGOS_AGL077W
uniprot id: Q751A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

284811:AGOS ADR335C
gene id: 284811:AGOS_ADR335C
uniprot id: Q759E2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer composed of 2 large adaptins (APL5 and APL6), a medium adaptin (APM3) and a small adaptin (APS3).
messages: Belongs to the adaptor complexes large subunit family.
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity).
messages: clathrin-coated vesicle membrane

284811:AGOS ADL275C
gene id: 284811:AGOS_ADL275C
uniprot id: Q75B52
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

284811:AGOS AER095W
gene id: 284811:AGOS_AER095W
uniprot id: Q757B8
names: Similarity
messages: Belongs to the CDC73 family.

284811:AGOS ABR157W
gene id: 284811:AGOS_ABR157W
uniprot id: Q75D66
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 3 Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Cytoplasm
messages: In eukaryotes this enzyme is synthesized by two pathway-specific (arginine and pyrimidine) under separate control.

284811:AGOS AAL059W
gene id: 284811:AGOS_AAL059W
uniprot id: Q75EY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein.
messages: Belongs to the PIGF family.
messages: Endoplasmic reticulum membrane

284811:AGOS ACL205C
gene id: 284811:AGOS_ACL205C
uniprot id: Q75CX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

284811:AGOS AER119W
gene id: 284811:AGOS_AER119W
uniprot id: Q756Z4
names: Similarity
messages: Belongs to the TSR2 family.

284811:AGOS AEL170C
gene id: 284811:AGOS_AEL170C
uniprot id: Q758C2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

284811:AGOS AAL064W
gene id: 284811:AGOS_AAL064W
uniprot id: Q75EZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AATF family.
messages: nucleolus

284811:AGOS AGL085C
gene id: 284811:AGOS_AGL085C
uniprot id: Q750N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
messages: Cell membrane
messages: The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

284811:AGOS ADR398W
gene id: 284811:AGOS_ADR398W
uniprot id: Q758Y0
names: Similarity
messages: Belongs to the BolA/IbaG family.

284811:AGOS AGR030C
gene id: 284811:AGOS_AGR030C
uniprot id: Q750C5
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

284811:AGOS AFL077C
gene id: 284811:AGOS_AFL077C
uniprot id: Q755A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KXD1 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1).
messages: Endosome

284811:AGOS AER367C
gene id: 284811:AGOS_AER367C
uniprot id: Q756A0
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

284811:AGOS AEL013C
gene id: 284811:AGOS_AEL013C
uniprot id: Q757M7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4 (By similarity).
messages: Nucleus

284811:AGOS AER098W
gene id: 284811:AGOS_AER098W
uniprot id: Q757B5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.

284811:AGOS ACR102W
gene id: 284811:AGOS_ACR102W
uniprot id: Q75C15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

284811:AGOS AAL172C
gene id: 284811:AGOS_AAL172C
uniprot id: Q75F88
names: Subunit
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

284811:AGOS ACR200C
gene id: 284811:AGOS_ACR200C
uniprot id: Q75BS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS ACR163W
gene id: 284811:AGOS_ACR163W
uniprot id: Q75BV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of 14, 12 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft (By similarity).
messages: Nucleus

284811:AGOS AFL153W
gene id: 284811:AGOS_AFL153W
uniprot id: Q755H6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

284811:AGOS AER103W
gene id: 284811:AGOS_AER103W
uniprot id: Q757B0
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

284811:AGOS AFR437W
gene id: 284811:AGOS_AFR437W
uniprot id: Q752Z6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

284811:AGOS AFR456C
gene id: 284811:AGOS_AFR456C
uniprot id: Q752W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

284811:AGOS ABL106C
gene id: 284811:AGOS_ABL106C
uniprot id: Q75DX9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
messages: Mitochondrion

284811:AGOS ADL365W
gene id: 284811:AGOS_ADL365W
uniprot id: Q75BD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

284811:AGOS AAR021W
gene id: 284811:AGOS_AAR021W
uniprot id: Q75EQ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

284811:AGOS AFR656C
gene id: 284811:AGOS_AFR656C
uniprot id: Q752B9
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AFR453W
gene id: 284811:AGOS_AFR453W
uniprot id: Q752X0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Interacts (via WxxxF/Y and LVxEF motifs) with PEX14; promoting translocation through the PEX13-PEX14 docking complex.
messages: Monoubiquitinated at Cys-5 by PEX2 during PEX5 passage through the retrotranslocation channel: monoubiquitination acts as a signal for PEX5 extraction and is required for proper export from peroxisomes and recycling. When PEX5 recycling is compromised, polyubiquitinated at Lys-17 by PEX10 during its passage through the retrotranslocation channel, leading to its degradation.
messages: Peroxisome matrix
messages: Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.
messages: The TPR repeats mediate interaction with proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type).
messages: The WxxxF/Y motifs mediate interaction with PEX14, promoting association with the PEX13-PEX14 docking complex.
messages: The amphipathic helix 1 and 2 (AH1 and AH2, respectively) are required for PEX5 retrotranslocation and recycling. AH2 mediates interaction with lumenal side of the PEX2-PEX10-PEX12 ligase complex, while AH1 is required for extraction from peroxisomal membrane by the PEX1-PEX6 AAA ATPase complex.
messages: cytosol

284811:AGOS AAR144W
gene id: 284811:AGOS_AAR144W
uniprot id: Q75ED1
names: Function
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.

284811:AGOS AEL113C
gene id: 284811:AGOS_AEL113C
uniprot id: Q757X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity).

284811:AGOS AER404C
gene id: 284811:AGOS_AER404C
uniprot id: Q755W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

284811:AGOS AGR035C
gene id: 284811:AGOS_AGR035C
uniprot id: Q750C2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes (By similarity).
messages: Mitochondrion
messages: Part of the mitochondrial small ribosomal subunit.

284811:AGOS ADR117W
gene id: 284811:AGOS_ADR117W
uniprot id: Q75A13
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

284811:AGOS AEL022W
gene id: 284811:AGOS_AEL022W
uniprot id: Q757N4
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

284811:AGOS AGL275W
gene id: 284811:AGOS_AGL275W
uniprot id: Q751I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.

284811:AGOS AFR211C
gene id: 284811:AGOS_AFR211C
uniprot id: Q753W1
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

284811:AGOS ACR097W
gene id: 284811:AGOS_ACR097W
uniprot id: Q75C20
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

284811:AGOS AGR006W
gene id: 284811:AGOS_AGR006W
uniprot id: Q750E9
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the peptidase M67A family.

284811:AGOS AER221W
gene id: 284811:AGOS_AER221W
uniprot id: Q756N3
names: Similarity
messages: Belongs to the SAICAR synthetase family.

284811:AGOS AFR382W
gene id: 284811:AGOS_AFR382W
uniprot id: Q753D4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the RSE1 family.
messages: Involved in pre-mRNA splicing and cell cycle control.
messages: Nucleus

284811:AGOS AFR512W
gene id: 284811:AGOS_AFR512W
uniprot id: Q752R1
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

284811:AGOS AFR210C
gene id: 284811:AGOS_AFR210C
uniprot id: Q753W2
names: Similarity
messages: Belongs to the syntaxin family.

284811:AGOS AAR027W
gene id: 284811:AGOS_AAR027W
uniprot id: Q75EQ2
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

284811:AGOS ADL302W
gene id: 284811:AGOS_ADL302W
uniprot id: Q75B74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.
messages: coated pit

284811:AGOS AEL216C
gene id: 284811:AGOS_AEL216C
uniprot id: Q758H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

284811:AGOS AER023C
gene id: 284811:AGOS_AER023C
uniprot id: Q757J0
names: Similarity
messages: Belongs to the SIN1 family.

284811:AGOS AER209W
gene id: 284811:AGOS_AER209W
uniprot id: Q756P5
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR063W
gene id: 284811:AGOS_AFR063W
uniprot id: Q754K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
messages: Nucleus

284811:AGOS AAL068C
gene id: 284811:AGOS_AAL068C
uniprot id: Q75EZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

284811:AGOS AEL008W
gene id: 284811:AGOS_AEL008W
uniprot id: Q757N0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
messages: Mitochondrion
messages: Mitochondrion inner membrane

284811:AGOS ADR049W
gene id: 284811:AGOS_ADR049W
uniprot id: Q75A69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Forms homooligomers. Interacts with MRS2.
messages: Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing.
messages: Mitochondrion inner membrane

284811:AGOS AER316C
gene id: 284811:AGOS_AER316C
uniprot id: Q756E9
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

284811:AGOS AGL298C
gene id: 284811:AGOS_AGL298C
uniprot id: Q751K4
names: Subcellular Location Annotation
messages: Cytoplasm

284811:AGOS ACR285C
gene id: 284811:AGOS_ACR285C
uniprot id: Q75BI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 15 family.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS ADR229C
gene id: 284811:AGOS_ADR229C
uniprot id: Q75A04
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AEL333W
gene id: 284811:AGOS_AEL333W
uniprot id: Q758T5
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

284811:AGOS AAR050C
gene id: 284811:AGOS_AAR050C
uniprot id: Q75EM9
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ABR112C
gene id: 284811:AGOS_ABR112C
uniprot id: Q75DB4
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AAR164C
gene id: 284811:AGOS_AAR164C
uniprot id: Q75EB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS AFR731W
gene id: 284811:AGOS_AFR731W
uniprot id: Q751U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Mitochondrion inner membrane

284811:AGOS ADL025W
gene id: 284811:AGOS_ADL025W
uniprot id: Q75AE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane

284811:AGOS ADL342W
gene id: 284811:AGOS_ADL342W
uniprot id: Q75BA9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

284811:AGOS AGR012C
gene id: 284811:AGOS_AGR012C
uniprot id: Q750E3
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

284811:AGOS AFR187C
gene id: 284811:AGOS_AFR187C
uniprot id: Q753Y5
names: Function
names: Similarity
messages: Belongs to the IRC19 family.
messages: Involved in sporulation and maintenance of the mitochondrial DNA. Is probably involved in a pathway contributing to genomic integrity (By similarity).

284811:AGOS AFR367W
gene id: 284811:AGOS_AFR367W
uniprot id: Q753Q1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Binds 1 FAD per monomer.
messages: Irreversibly catalyzes the reduction of fumarate to succinate.

284811:AGOS AEL097C
gene id: 284811:AGOS_AEL097C
uniprot id: Q757V9
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

284811:AGOS AEL255W
gene id: 284811:AGOS_AEL255W
uniprot id: Q758L6
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

284811:AGOS AAL174C
gene id: 284811:AGOS_AAL174C
uniprot id: Q75F90
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

284811:AGOS ADR394W
gene id: 284811:AGOS_ADR394W
uniprot id: Q758Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VTS1 family.
messages: Monomer. Binds to RNA.
messages: P-body
messages: RNA-binding protein involved in post-transcriptional regulation through transcript degradation.
messages: cytosol

284811:AGOS ACR138W
gene id: 284811:AGOS_ACR138W
uniprot id: Q75BY2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation at Lys-252 is required for proper function.
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z (By similarity). Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity). The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity). Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins (By similarity). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity).
messages: Chromosome
messages: Component of the NuA4 histone acetyltransferase complex (By similarity). Interacts with arp4 (By similarity).
messages: Nucleus
messages: The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity.

284811:AGOS AFR564W
gene id: 284811:AGOS_AFR564W
uniprot id: Q752L0
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.

284811:AGOS AFR174W
gene id: 284811:AGOS_AFR174W
uniprot id: Q753Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRG1 family.
messages: Essential for respiratory growth and required for mitochondrial protein synthesis. Required for vacuolar acidification (By similarity).
messages: Mitochondrion

284811:AGOS AFR573C
gene id: 284811:AGOS_AFR573C
uniprot id: Q752K1
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

284811:AGOS ADL175W
gene id: 284811:AGOS_ADL175W
uniprot id: Q75AU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

284811:AGOS AFR462C
gene id: 284811:AGOS_AFR462C
uniprot id: Q752W1
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR442C
gene id: 284811:AGOS_AFR442C
uniprot id: Q752Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

284811:AGOS AGL007W
gene id: 284811:AGOS_AGL007W
uniprot id: Q750L0
names: Function
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: Required for respiration.

284811:AGOS AFR093W
gene id: 284811:AGOS_AFR093W
uniprot id: Q754I3
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

284811:AGOS AER458C
gene id: 284811:AGOS_AER458C
uniprot id: Q755R0
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

284811:AGOS AFR603C
gene id: 284811:AGOS_AFR603C
uniprot id: Q752H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).
messages: Nucleus

284811:AGOS ADL146W
gene id: 284811:AGOS_ADL146W
uniprot id: Q75AR6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

284811:AGOS AEL138C
gene id: 284811:AGOS_AEL138C
uniprot id: Q757Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG27 family.
messages: Cytoplasmic vesicle membrane
messages: Effector of VPS34 phosphatidylinositol 3-phosphate kinase signaling. Regulates the cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9 (By similarity).
messages: Golgi apparatus membrane
messages: Mitochondrion membrane
messages: Preautophagosomal structure membrane

284811:AGOS ADR316W
gene id: 284811:AGOS_ADR316W
uniprot id: Q759G0
names: Similarity
messages: Belongs to the actin family.

284811:AGOS AEL259W
gene id: 284811:AGOS_AEL259W
uniprot id: Q758M0
names: Similarity
messages: Belongs to the PAPS reductase family. CysH subfamily.

284811:AGOS ADR349W
gene id: 284811:AGOS_ADR349W
uniprot id: Q759C8
names: Similarity
messages: Belongs to the MAK16 family.

284811:AGOS ACL158W
gene id: 284811:AGOS_ACL158W
uniprot id: Q75CS7
names: Similarity
messages: Belongs to the CENP-X/MHF2 family.

284811:AGOS AFL213W
gene id: 284811:AGOS_AFL213W
uniprot id: Q755M7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

284811:AGOS ACR048C
gene id: 284811:AGOS_ACR048C
uniprot id: Q75C68
names: Similarity
messages: Belongs to the LTV1 family.

284811:AGOS AGR192C
gene id: 284811:AGOS_AGR192C
uniprot id: Q74ZK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Forms a complex with TRM82.
messages: Nucleus

284811:AGOS AGL253C
gene id: 284811:AGOS_AGL253C
uniprot id: Q751F9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the CRL3 E3 ubiquitin ligase complex; polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair. Prevents degradation of interacting proteins by the proteasome.
messages: Belongs to the SKP1 family.
messages: Cytoplasm
messages: Heterodimer with ELA1. Component of a CRL3 E3 ubiquitin ligase complex consisting of a cullin, the linker protein ELC1, the substrate receptor ELA1, and a RING protein.
messages: Nucleus

284811:AGOS AAR041W
gene id: 284811:AGOS_AAR041W
uniprot id: Q75EN8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.
messages: Cytoplasm
messages: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
messages: Signal recognition particle consists of a 7S RNA molecule and at least six protein subunits.

284811:AGOS AAL030C
gene id: 284811:AGOS_AAL030C
uniprot id: Q75EV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

284811:AGOS ADR328W
gene id: 284811:AGOS_ADR328W
uniprot id: Q759E9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAM17 family.
messages: Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Component of the PAM complex, at least composed of mtHsp70 (SSC1), MGE1, TIM44, PAM16, PAM17 and PAM18.
messages: Mitochondrion inner membrane

284811:AGOS ADL006W
gene id: 284811:AGOS_ADL006W
uniprot id: Q75AC3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NBP35 and two labile, bridging clusters between subunits of the NBP35-CFD1 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.
messages: Cytoplasm
messages: Heterotetramer of 2 NBP35 and 2 CFD1 chains.

284811:AGOS ACR120C
gene id: 284811:AGOS_ACR120C
uniprot id: Q75BZ9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

284811:AGOS AER127C
gene id: 284811:AGOS_AER127C
uniprot id: Q756Y7
names: Similarity
messages: Belongs to the type-1 OGG1 family.

284811:AGOS ADR185W
gene id: 284811:AGOS_ADR185W
uniprot id: Q759T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity).
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

284811:AGOS AFR144W
gene id: 284811:AGOS_AFR144W
uniprot id: Q754C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

284811:AGOS AER375C
gene id: 284811:AGOS_AER375C
uniprot id: Q755Z2
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ADL099C
gene id: 284811:AGOS_ADL099C
uniprot id: Q75AM2
names: Similarity
names: Subunit
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer (By similarity).

284811:AGOS ABR138C
gene id: 284811:AGOS_ABR138C
uniprot id: Q75D86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

284811:AGOS AFR733W
gene id: 284811:AGOS_AFR733W
uniprot id: Q751U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGX family.
messages: Endoplasmic reticulum membrane
messages: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14 (By similarity).

284811:AGOS ABR171W
gene id: 284811:AGOS_ABR171W
uniprot id: Q75D52
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

284811:AGOS AAL118C
gene id: 284811:AGOS_AAL118C
uniprot id: Q75F46
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: cytoskeleton

284811:AGOS AFR281C
gene id: 284811:AGOS_AFR281C
uniprot id: Q753N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.
messages: Nucleus
messages: kinetochore

284811:AGOS AAR154W
gene id: 284811:AGOS_AAR154W
uniprot id: Q75EC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDS23 family.
messages: Cytoplasm
messages: Involved in DNA replication and cell separation.
messages: Nucleus

284811:AGOS AEL341W
gene id: 284811:AGOS_AEL341W
uniprot id: Q758U3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

284811:AGOS AGL156W
gene id: 284811:AGOS_AGL156W
uniprot id: Q750U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

284811:AGOS AFL098W
gene id: 284811:AGOS_AFL098W
uniprot id: Q755C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Endoplasmic reticulum membrane
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.

284811:AGOS ABL166W
gene id: 284811:AGOS_ABL166W
uniprot id: Q75E36
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

284811:AGOS AER377C
gene id: 284811:AGOS_AER377C
uniprot id: Q755Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MET18/MMS19 family.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus

284811:AGOS ABR233W
gene id: 284811:AGOS_ABR233W
uniprot id: Q75CY9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.

284811:AGOS AFR058C
gene id: 284811:AGOS_AFR058C
uniprot id: Q754L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC2 family.
messages: Nucleus

284811:AGOS ADR282C
gene id: 284811:AGOS_ADR282C
uniprot id: Q759J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM36 family.
messages: Mitochondrion membrane

284811:AGOS ABR023C
gene id: 284811:AGOS_ABR023C
uniprot id: Q75DJ9
names: Similarity
messages: Belongs to the ISF1/MBR1 family.

284811:AGOS AAR048W
gene id: 284811:AGOS_AAR048W
uniprot id: Q75EN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.

284811:AGOS ACR006C
gene id: 284811:AGOS_ACR006C
uniprot id: Q75CA6
names: Similarity
messages: Belongs to the UPF0507 family.

284811:AGOS AFL181C
gene id: 284811:AGOS_AFL181C
uniprot id: Q755Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG2 family.
messages: Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.
messages: Endoplasmic reticulum membrane

284811:AGOS AER200C
gene id: 284811:AGOS_AER200C
uniprot id: Q756Q4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with the flavoprotein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

284811:AGOS AGR337W
gene id: 284811:AGOS_AGR337W
uniprot id: Q74Z69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: Membrane

284811:AGOS AFR543C
gene id: 284811:AGOS_AFR543C
uniprot id: Q752N1
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AER400C
gene id: 284811:AGOS_AER400C
uniprot id: Q755W8
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

284811:AGOS ACR094C
gene id: 284811:AGOS_ACR094C
uniprot id: Q75C23
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

284811:AGOS ABR246W
gene id: 284811:AGOS_ABR246W
uniprot id: Q75CX6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

284811:AGOS AEL074W
gene id: 284811:AGOS_AEL074W
uniprot id: Q757T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.
messages: Vacuole membrane

284811:AGOS ADR006W
gene id: 284811:AGOS_ADR006W
uniprot id: Q75AB2
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

284811:AGOS AFR624W
gene id: 284811:AGOS_AFR624W
uniprot id: Q752F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

284811:AGOS AAL162C
gene id: 284811:AGOS_AAL162C
uniprot id: Q75F93
names: Function
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.
messages: Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

284811:AGOS AER301C
gene id: 284811:AGOS_AER301C
uniprot id: Q756G5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity).
messages: Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

284811:AGOS ABL123C
gene id: 284811:AGOS_ABL123C
uniprot id: Q75DZ6
names: Similarity
messages: Belongs to the peptidase A1 family.

284811:AGOS ADR092W
gene id: 284811:AGOS_ADR092W
uniprot id: Q75A28
names: Similarity
messages: Belongs to the UPP synthase family.

284811:AGOS AGR391W
gene id: 284811:AGOS_AGR391W
uniprot id: Q74ZG3
names: Similarity
messages: Belongs to the PPC synthetase family.

284811:AGOS ADR295C
gene id: 284811:AGOS_ADR295C
uniprot id: Q759H8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SKP1 family.
messages: Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.

284811:AGOS ADR066C
gene id: 284811:AGOS_ADR066C
uniprot id: Q75A53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.

284811:AGOS AFR142C
gene id: 284811:AGOS_AFR142C
uniprot id: Q754C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
messages: Cytoplasm

284811:AGOS AEL267C
gene id: 284811:AGOS_AEL267C
uniprot id: Q758V1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication.
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Heterotetramer. Consists of four subunits: POL2, DPB2, DPB3 and DPB4 (By similarity).
messages: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
messages: Nucleus

284811:AGOS AAR082W
gene id: 284811:AGOS_AAR082W
uniprot id: Q75EJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

284811:AGOS AGR165W
gene id: 284811:AGOS_AGR165W
uniprot id: Q74ZN3
names: Similarity
messages: Belongs to the R-transferase family.

284811:AGOS AER214C
gene id: 284811:AGOS_AER214C
uniprot id: Q756P0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA).
messages: Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles that contain SNU13, NOP1, SIK1/NOP56 and NOP58, plus a guide RNA.
messages: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity).
messages: nucleolus

284811:AGOS AEL194W
gene id: 284811:AGOS_AEL194W
uniprot id: Q758F6
names: Similarity
messages: Belongs to the CNOT9 family.

284811:AGOS AFR638C
gene id: 284811:AGOS_AFR638C
uniprot id: Q752D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

284811:AGOS ACR204C
gene id: 284811:AGOS_ACR204C
uniprot id: Q75BR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
messages: Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape (By similarity).
messages: Cytoplasm
messages: Nucleus

284811:AGOS ACL004W
gene id: 284811:AGOS_ACL004W
uniprot id: Q75CF0
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ABR015C
gene id: 284811:AGOS_ABR015C
uniprot id: Q75DK6
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

284811:AGOS AGL286C
gene id: 284811:AGOS_AGL286C
uniprot id: Q751J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHO1 family.
messages: Cell membrane
messages: Forms homooligomers.
messages: Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.

284811:AGOS ADR235W
gene id: 284811:AGOS_ADR235W
uniprot id: Q759P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton (By similarity).
messages: Cytoplasm
messages: Nucleus matrix
messages: cytoskeleton

284811:AGOS ADR264C
gene id: 284811:AGOS_ADR264C
uniprot id: Q759L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

284811:AGOS ACR137W
gene id: 284811:AGOS_ACR137W
uniprot id: Q75BY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the WD repeat PRL1/PRL2 family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.
messages: Nucleus

284811:AGOS ADR044C
gene id: 284811:AGOS_ADR044C
uniprot id: Q75A74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing (By similarity).

284811:AGOS ADL130W
gene id: 284811:AGOS_ADL130W
uniprot id: Q75AQ0
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

284811:AGOS AEL205W
gene id: 284811:AGOS_AEL205W
uniprot id: Q9HFW2
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Required for hyphal maturation and for septation.

284811:AGOS AFL186W
gene id: 284811:AGOS_AFL186W
uniprot id: Q755K3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG16 family.
messages: Homodimer (By similarity). Part of the ATG5-ATG12/ATG16 complex. Several units of each may be present in this complex (By similarity).
messages: Preautophagosomal structure membrane
messages: Stabilizes the ATG5-ATG12 conjugate which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).

284811:AGOS AFR641W
gene id: 284811:AGOS_AFR641W
uniprot id: Q752D5
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

284811:AGOS AER419W
gene id: 284811:AGOS_AER419W
uniprot id: Q755U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS AER222C
gene id: 284811:AGOS_AER222C
uniprot id: Q756N2
names: Similarity
messages: Belongs to the protein kinase superfamily.

284811:AGOS ACL067C
gene id: 284811:AGOS_ACL067C
uniprot id: Q75CI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.
messages: Membrane

284811:AGOS AFR155W
gene id: 284811:AGOS_AFR155W
uniprot id: Q754B5
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

284811:AGOS AGL020W
gene id: 284811:AGOS_AGL020W
uniprot id: Q750H3
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

284811:AGOS AAR055W
gene id: 284811:AGOS_AAR055W
uniprot id: Q75EM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

284811:AGOS ACR233W
gene id: 284811:AGOS_ACR233W
uniprot id: Q75BN8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

284811:AGOS AER405C
gene id: 284811:AGOS_AER405C
uniprot id: Q755W3
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADL081C
gene id: 284811:AGOS_ADL081C
uniprot id: Q75AK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity (By similarity).
messages: Cytoplasm

284811:AGOS AER116C
gene id: 284811:AGOS_AER116C
uniprot id: Q756Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG23 family.
messages: Cytoplasm
messages: Membrane
messages: Required for cytoplasm to vacuole transport (Cvt) vesicle formation and efficient autophagy. Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9. Also plays a role in regulation of filamentous growth (By similarity).

284811:AGOS ABR054C
gene id: 284811:AGOS_ABR054C
uniprot id: Q75DH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPC42 family.
messages: Forms a polymeric layer at the periphery of the spindle pole body (SPB) central plaque which has an essential function during SPB duplication and may facilitate attachment of the SPB to the nuclear membrane.
messages: Nucleus
messages: spindle pole body

284811:AGOS ADR020C
gene id: 284811:AGOS_ADR020C
uniprot id: Q75A98
names: Similarity
messages: Belongs to the MNN1/MNT family.

284811:AGOS AER325W
gene id: 284811:AGOS_AER325W
uniprot id: Q756E2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus

284811:AGOS ADL394C
gene id: 284811:AGOS_ADL394C
uniprot id: Q752D3
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AGL209W
gene id: 284811:AGOS_AGL209W
uniprot id: Q750Z6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: May be involved in vacuolar sorting and osmoregulation.
messages: Vacuole membrane

284811:AGOS AAL131C
gene id: 284811:AGOS_AAL131C
uniprot id: Q75F59
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: The C2 domains have an essential, but non-catalytic function. They may facilitate interaction with PstB2 and are required for lipid transport function.

284811:AGOS AER252C
gene id: 284811:AGOS_AER252C
uniprot id: Q756K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

284811:AGOS AFR682C
gene id: 284811:AGOS_AFR682C
uniprot id: Q751Z3
names: Similarity
messages: Belongs to the AB hydrolase superfamily. MetX family.

284811:AGOS AFR087W
gene id: 284811:AGOS_AFR087W
uniprot id: Q754I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family.
messages: Cell membrane
messages: Vacuole membrane

284811:AGOS AFR443C
gene id: 284811:AGOS_AFR443C
uniprot id: Q752Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku70 family.
messages: Nucleus
messages: telomere

284811:AGOS ADL079C
gene id: 284811:AGOS_ADL079C
uniprot id: Q75AK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

284811:AGOS AEL322W
gene id: 284811:AGOS_AEL322W
uniprot id: Q758S4
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

284811:AGOS AGR319W
gene id: 284811:AGOS_AGR319W
uniprot id: Q74Z84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

284811:AGOS ADR411W
gene id: 284811:AGOS_ADR411W
uniprot id: Q758W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the rad1 family.
messages: Component of the checkpoint clamp complex composed of DDC1, MEC3 and RAD17.
messages: Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.
messages: Nucleus

284811:AGOS AAR040C
gene id: 284811:AGOS_AAR040C
uniprot id: Q75EN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCZ1 family.
messages: Forms a complex with MON1.
messages: In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.
messages: Prevacuolar compartment membrane
messages: Vacuole membrane
messages: multivesicular body membrane

284811:AGOS AGR009C
gene id: 284811:AGOS_AGR009C
uniprot id: Q750E6
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AFL195W
gene id: 284811:AGOS_AFL195W
uniprot id: Q755K9
names: Similarity
messages: Belongs to the lipin family.

284811:AGOS AAR075C
gene id: 284811:AGOS_AAR075C
uniprot id: Q75EK4
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

284811:AGOS AGL361C
gene id: 284811:AGOS_AGL361C
uniprot id: Q751Q0
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AFR078W
gene id: 284811:AGOS_AFR078W
uniprot id: Q754J4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM16/PAM16 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
messages: Heterodimer with PAM18. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18 (By similarity).
messages: Mitochondrion inner membrane
messages: The J-like region, although related to the J domain does not stimulate ATPase activity of mtHSP70. It nevertheless mediates the heterodimerization with the J domain of PAM18 and is therefore essential for PAM complex function (By similarity).

284811:AGOS AGL031W
gene id: 284811:AGOS_AGL031W
uniprot id: Q750I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.
messages: Cytoplasm
messages: Nucleus

284811:AGOS ACR247W
gene id: 284811:AGOS_ACR247W
uniprot id: Q75BM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFH5 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.

284811:AGOS AGL249C
gene id: 284811:AGOS_AGL249C
uniprot id: Q751F5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Component of the SRB8-11 complex, a regulatory module of the Mediator complex.
messages: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
messages: Nucleus

284811:AGOS ADL397C
gene id: 284811:AGOS_ADL397C
uniprot id: Q75BF9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

284811:AGOS AFL211W
gene id: 284811:AGOS_AFL211W
uniprot id: Q755M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMP46 family.
messages: Mitochondrion
messages: Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.

284811:AGOS AGR181W
gene id: 284811:AGOS_AGR181W
uniprot id: Q74ZL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with nucleolar pre-ribosomal particles.
messages: Belongs to the RSA3 family.
messages: Required for efficient biogenesis of the 60S ribosomal subunit.
messages: nucleolus

284811:AGOS AFR178W
gene id: 284811:AGOS_AFR178W
uniprot id: Q753Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

284811:AGOS ABR235W
gene id: 284811:AGOS_ABR235W
uniprot id: Q75CY7
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

284811:AGOS AAL116W
gene id: 284811:AGOS_AAL116W
uniprot id: Q75F44
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the peptidase M67A family.

284811:AGOS ACL098C
gene id: 284811:AGOS_ACL098C
uniprot id: Q75CL7
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

284811:AGOS AEL065C
gene id: 284811:AGOS_AEL065C
uniprot id: Q757S7
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AGR305W
gene id: 284811:AGOS_AGR305W
uniprot id: Q74Z98
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

284811:AGOS AGR259C
gene id: 284811:AGOS_AGR259C
uniprot id: Q74ZE0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

284811:AGOS ADL346W
gene id: 284811:AGOS_ADL346W
uniprot id: Q75BB3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Binds 1 phosphopantetheine covalently.
messages: Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.
messages: Heterodimer of an alpha and a beta subunit.

284811:AGOS ADL388W
gene id: 284811:AGOS_ADL388W
uniprot id: Q75BF2
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ABR193W
gene id: 284811:AGOS_ABR193W
uniprot id: Q75D29
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity).

284811:AGOS ADL356C
gene id: 284811:AGOS_ADL356C
uniprot id: Q75BC3
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

284811:AGOS AGL146W
gene id: 284811:AGOS_AGL146W
uniprot id: Q750T5
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.

284811:AGOS ACR250W
gene id: 284811:AGOS_ACR250W
uniprot id: Q75BM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

284811:AGOS AFR356C
gene id: 284811:AGOS_AFR356C
uniprot id: Q753F8
names: PTM
names: Similarity
messages: Belongs to the eIF-5A family.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

284811:AGOS AFR014C
gene id: 284811:AGOS_AFR014C
uniprot id: Q754Q8
names: Similarity
messages: Belongs to the NFYB/HAP3 subunit family.

284811:AGOS ABR203W
gene id: 284811:AGOS_ABR203W
uniprot id: Q75D19
names: Domain
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

284811:AGOS AFL050W
gene id: 284811:AGOS_AFL050W
uniprot id: Q754W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC) involved in the nuclear export of capped U snRNAs. The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation; and involved in rRNA processing at sites A0, A1 and A2 (By similarity).
messages: Component of the nuclear cap-binding complex (CBC).
messages: Nucleus

284811:AGOS AGL353W
gene id: 284811:AGOS_AGL353W
uniprot id: Q751P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 48 family.
messages: Membrane

284811:AGOS ABR249W
gene id: 284811:AGOS_ABR249W
uniprot id: Q75CX5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

284811:AGOS ABR110W
gene id: 284811:AGOS_ABR110W
uniprot id: Q75DB6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.

284811:AGOS ADL239C
gene id: 284811:AGOS_ADL239C
uniprot id: Q75B16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.

284811:AGOS AGL212W
gene id: 284811:AGOS_AGL212W
uniprot id: Q751B8
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ABR078C
gene id: 284811:AGOS_ABR078C
uniprot id: Q75DS2
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

284811:AGOS AEL311W
gene id: 284811:AGOS_AEL311W
uniprot id: Q758R4
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

284811:AGOS AAL094W
gene id: 284811:AGOS_AAL094W
uniprot id: Q75F22
names: Similarity
messages: Belongs to the APC5 family.

284811:AGOS AFL076W
gene id: 284811:AGOS_AFL076W
uniprot id: Q755A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer composed of 2 large adaptins (APL5 and APL6), a medium adaptin (APM3) and a small adaptin (APS3).
messages: Belongs to the adaptor complexes large subunit family.
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity).
messages: clathrin-coated vesicle membrane

284811:AGOS AFR615W
gene id: 284811:AGOS_AFR615W
uniprot id: Q752G1
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

284811:AGOS AEL204C
gene id: 284811:AGOS_AEL204C
uniprot id: E7FHV0
names: Similarity
messages: Belongs to the MON2 family.

284811:AGOS AFR024C
gene id: 284811:AGOS_AFR024C
uniprot id: Q754P8
names: Similarity
messages: Belongs to the FAH family.

284811:AGOS AER067C
gene id: 284811:AGOS_AER067C
uniprot id: Q757E6
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

284811:AGOS AGR175C
gene id: 284811:AGOS_AGR175C
uniprot id: Q74ZM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

284811:AGOS ADL065W
gene id: 284811:AGOS_ADL065W
uniprot id: Q75AJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RGI1 family.
messages: Cell membrane
messages: Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.

284811:AGOS AEL223C
gene id: 284811:AGOS_AEL223C
uniprot id: Q758I5
names: Similarity
messages: Belongs to the ClpA/ClpB family.

284811:AGOS AER280C
gene id: 284811:AGOS_AER280C
uniprot id: Q756I1
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AEL042C
gene id: 284811:AGOS_AEL042C
uniprot id: Q757Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

284811:AGOS ADR197W
gene id: 284811:AGOS_ADR197W
uniprot id: Q759S6
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

284811:AGOS AEL162W
gene id: 284811:AGOS_AEL162W
uniprot id: Q758B4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

284811:AGOS AER174W
gene id: 284811:AGOS_AER174W
uniprot id: Q756S9
names: Similarity
messages: Belongs to the CBF/MAK21 family.

284811:AGOS AFR361C
gene id: 284811:AGOS_AFR361C
uniprot id: Q753F3
names: Similarity
messages: Belongs to the NAD kinase family.

284811:AGOS ADR399C
gene id: 284811:AGOS_ADR399C
uniprot id: Q758X9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

284811:AGOS AFR318W
gene id: 284811:AGOS_AFR318W
uniprot id: Q753J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

284811:AGOS AFR454W
gene id: 284811:AGOS_AFR454W
uniprot id: Q752W9
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.

284811:AGOS ADL333C
gene id: 284811:AGOS_ADL333C
uniprot id: Q75B99
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

284811:AGOS ACL035C
gene id: 284811:AGOS_ACL035C
uniprot id: Q75CE1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Mitochondrion inner membrane

284811:AGOS AEL326C
gene id: 284811:AGOS_AEL326C
uniprot id: Q758S8
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

284811:AGOS AFR009W
gene id: 284811:AGOS_AFR009W
uniprot id: Q754R3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

284811:AGOS ADR192C
gene id: 284811:AGOS_ADR192C
uniprot id: Q759T1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Endomembrane system
messages: Endosome membrane
messages: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy.
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.

284811:AGOS AFR504W
gene id: 284811:AGOS_AFR504W
uniprot id: Q752R9
names: Similarity
messages: Belongs to the cytidylyltransferase family.

284811:AGOS AEL011W
gene id: 284811:AGOS_AEL011W
uniprot id: Q757M5
names: Similarity
messages: Belongs to the AAA ATPase family.

284811:AGOS AFR614W
gene id: 284811:AGOS_AFR614W
uniprot id: Q752G2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic12 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

284811:AGOS AGR318C
gene id: 284811:AGOS_AGR318C
uniprot id: Q74Z85
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

284811:AGOS AGL165W
gene id: 284811:AGOS_AGL165W
uniprot id: Q750V4
names: Function
names: Similarity
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate.

284811:AGOS AFL011W
gene id: 284811:AGOS_AFL011W
uniprot id: Q754T2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

284811:AGOS ACL022W
gene id: 284811:AGOS_ACL022W
uniprot id: Q75CD1
names: Similarity
messages: Belongs to the IMPACT family.

284811:AGOS AGL247C
gene id: 284811:AGOS_AGL247C
uniprot id: Q751F3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

284811:AGOS AAL055C
gene id: 284811:AGOS_AAL055C
uniprot id: Q75EY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS ACR131C
gene id: 284811:AGOS_ACR131C
uniprot id: Q75BY9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated to ATG12; which is essential for autophagy.
messages: Conjugated with ATG12.
messages: Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).
messages: Preautophagosomal structure membrane

284811:AGOS AGR169W
gene id: 284811:AGOS_AGR169W
uniprot id: Q74ZM9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Monomer.

284811:AGOS AAR049C
gene id: 284811:AGOS_AAR049C
uniprot id: Q75EN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAD18 family.
messages: E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
messages: Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.
messages: Nucleus

284811:AGOS AEL043W
gene id: 284811:AGOS_AEL043W
uniprot id: Q757Q5
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AER387C
gene id: 284811:AGOS_AER387C
uniprot id: Q755Y1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

284811:AGOS AER224W
gene id: 284811:AGOS_AER224W
uniprot id: Q756N0
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

284811:AGOS AGR314W
gene id: 284811:AGOS_AGR314W
uniprot id: Q74Z89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

284811:AGOS ABR033C
gene id: 284811:AGOS_ABR033C
uniprot id: Q75DJ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

284811:AGOS AFR617C
gene id: 284811:AGOS_AFR617C
uniprot id: Q752F9
names: Similarity
messages: Belongs to the cullin family.

284811:AGOS AFL201W
gene id: 284811:AGOS_AFL201W
uniprot id: Q755L5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

284811:AGOS AFR319W
gene id: 284811:AGOS_AFR319W
uniprot id: Q753J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

284811:AGOS AGL173W
gene id: 284811:AGOS_AGL173W
uniprot id: Q750W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAC3 family.
messages: Nucleus envelope

284811:AGOS ACL144C
gene id: 284811:AGOS_ACL144C
uniprot id: Q75CR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

284811:AGOS ACL147W
gene id: 284811:AGOS_ACL147W
uniprot id: Q75CR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

284811:AGOS AFR681W
gene id: 284811:AGOS_AFR681W
uniprot id: Q751Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family.
messages: Cytoplasm
messages: Membrane
messages: Probable sterol 3-beta-glucosyltransferase that is not involved in cytoplasm to vacuole transport (Cvt), pexophagy or nonselective autophagy (By similarity).

284811:AGOS ADL073W
gene id: 284811:AGOS_ADL073W
uniprot id: Q75AK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

284811:AGOS AFL095W
gene id: 284811:AGOS_AFL095W
uniprot id: Q755B8
names: Subcellular Location Annotation
messages: Cell surface

284811:AGOS ADL004W
gene id: 284811:AGOS_ADL004W
uniprot id: Q75AC1
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

284811:AGOS AFR390C
gene id: 284811:AGOS_AFR390C
uniprot id: Q753C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNO1 family.
messages: Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).
messages: Cytoplasm
messages: Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species (By similarity).
messages: nucleolus

284811:AGOS AGL280W
gene id: 284811:AGOS_AGL280W
uniprot id: Q751I6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS AGL272C
gene id: 284811:AGOS_AGL272C
uniprot id: Q751H8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

284811:AGOS AEL306C
gene id: 284811:AGOS_AEL306C
uniprot id: Q758Q9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Phosphorylation of the TEDS site (Ser-356) is required for the polarization of the actin cytoskeleton. Phosphorylation probably activates the myosin-I ATPase activity (By similarity).
messages: The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force.
messages: The tail domain participates in molecular interactions that specify the role of the motor domain (By similarity). It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding myosin tail domain (also named TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3).
messages: Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex (By similarity).
messages: actin patch

284811:AGOS AER237W
gene id: 284811:AGOS_AER237W
uniprot id: Q756L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

284811:AGOS AAR167C
gene id: 284811:AGOS_AAR167C
uniprot id: Q75EB0
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

284811:AGOS AFR626W
gene id: 284811:AGOS_AFR626W
uniprot id: Q752F0
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

284811:AGOS AER106C
gene id: 284811:AGOS_AER106C
uniprot id: Q757A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity).
messages: Belongs to the ATG17 family.
messages: Cytoplasm
messages: Preautophagosomal structure membrane

284811:AGOS AGR114C
gene id: 284811:AGOS_AGR114C
uniprot id: Q74ZT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

284811:AGOS AEL068W
gene id: 284811:AGOS_AEL068W
uniprot id: Q757T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HUL4 family.
messages: Component of the TRAMP complex.
messages: Nucleus
messages: Probable E3 ubiquitin-protein ligase, component of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates.

284811:AGOS ACR042C
gene id: 284811:AGOS_ACR042C
uniprot id: Q75C74
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.

284811:AGOS ABR168W
gene id: 284811:AGOS_ABR168W
uniprot id: Q75D55
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

284811:AGOS ACL148C
gene id: 284811:AGOS_ACL148C
uniprot id: Q75CR7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

284811:AGOS ACL186W
gene id: 284811:AGOS_ACL186W
uniprot id: Q75CV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

284811:AGOS ACR035W
gene id: 284811:AGOS_ACR035W
uniprot id: Q75C81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

284811:AGOS AAL003W
gene id: 284811:AGOS_AAL003W
uniprot id: Q75ET1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

284811:AGOS AAL069C
gene id: 284811:AGOS_AAL069C
uniprot id: Q75EZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HDA2/3 family. HDA2 subfamily.
messages: Nucleus
messages: Probable component of some histone deacetylase complex.
messages: Required for activity of histone deacetylase complexes that are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity).

284811:AGOS ABR100W
gene id: 284811:AGOS_ABR100W
uniprot id: Q75DC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSM3 family.
messages: Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.
messages: Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
messages: Nucleus

284811:AGOS ACL149W
gene id: 284811:AGOS_ACL149W
uniprot id: Q75CR8
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ADR160W
gene id: 284811:AGOS_ADR160W
uniprot id: Q759W2
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

284811:AGOS ACL076W
gene id: 284811:AGOS_ACL076W
uniprot id: Q75CJ5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.

284811:AGOS ADL167W
gene id: 284811:AGOS_ADL167W
uniprot id: Q75AT7
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

284811:AGOS AGR290W
gene id: 284811:AGOS_AGR290W
uniprot id: Q74ZG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

284811:AGOS AEL345W
gene id: 284811:AGOS_AEL345W
uniprot id: Q758U7
names: Similarity
messages: Belongs to the MNN1/MNT family.

284811:AGOS AER037C
gene id: 284811:AGOS_AER037C
uniprot id: Q757H6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.
messages: Homodimer.

284811:AGOS AAL058C
gene id: 284811:AGOS_AAL058C
uniprot id: Q75EY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM24 family.
messages: Mitochondrion

284811:AGOS AFR129W
gene id: 284811:AGOS_AFR129W
uniprot id: Q754E1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

284811:AGOS AGL168W
gene id: 284811:AGOS_AGL168W
uniprot id: Q750V7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC15 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

284811:AGOS ABR190C
gene id: 284811:AGOS_ABR190C
uniprot id: Q75D33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INA17 family.
messages: Component of the INA complex (INAC) that promotes the biogenesis of mitochondrial F(1)F(0)-ATP synthase. INAC facilitates the assembly of the peripheral stalk and promotes the assembly of the catalytic F(1)-domain with the membrane-embedded F(0)-domain.
messages: Component of the inner membrane assembly (INA) complex, composed of INA17 and INA22. Interacts with a subset of F(1)F(0)-ATP synthase subunits of the F(1)-domain and the peripheral stalk.
messages: Mitochondrion inner membrane

284811:AGOS AGL224W
gene id: 284811:AGOS_AGL224W
uniprot id: Q751D0
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

284811:AGOS AAR019W
gene id: 284811:AGOS_AAR019W
uniprot id: Q75ER0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

284811:AGOS ABR098C
gene id: 284811:AGOS_ABR098C
uniprot id: Q75DC9
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AER365W
gene id: 284811:AGOS_AER365W
uniprot id: Q756A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

284811:AGOS AGL182C
gene id: 284811:AGOS_AGL182C
uniprot id: Q750X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

284811:AGOS AGL301C
gene id: 284811:AGOS_AGL301C
uniprot id: Q751R9
names: Similarity
messages: Belongs to the WD repeat rae1 family.

284811:AGOS ACR015W
gene id: 284811:AGOS_ACR015W
uniprot id: Q75CE5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.

284811:AGOS ADL184W
gene id: 284811:AGOS_ADL184W
uniprot id: Q75AV4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).

284811:AGOS ADR011C
gene id: 284811:AGOS_ADR011C
uniprot id: Q75AA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.
messages: Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.
messages: Nucleus

284811:AGOS AAR112C
gene id: 284811:AGOS_AAR112C
uniprot id: Q75EG6
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Allosterically activated by ATP (By similarity). ATP binding is a prerequisite to magnesium and substrate binding. ATP binds to 2 of the subunits in the homotetramer inducing a closure of these 2 subunits and the release of the C-terminal loop, thereby activating the enzyme (By similarity).
messages: Belongs to the ISN1 family.
messages: Homotetramer.
messages: IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.

284811:AGOS ADL317C
gene id: 284811:AGOS_ADL317C
uniprot id: Q75B87
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

284811:AGOS AER315C
gene id: 284811:AGOS_AER315C
uniprot id: Q756F0
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

284811:AGOS AFL103C
gene id: 284811:AGOS_AFL103C
uniprot id: Q755C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

284811:AGOS AMI001W
gene id: 284811:AGOS_AMI001W
uniprot id: Q7YFV7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a dinuclear copper A center per subunit.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane
messages: The signal sequence of COX2 is processed by IMP1.

284811:AGOS AEL071C
gene id: 284811:AGOS_AEL071C
uniprot id: Q757T3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

284811:AGOS ABR077C
gene id: 284811:AGOS_ABR077C
uniprot id: Q75DE9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEF1 family.
messages: Cytoplasm
messages: Homodimer; may form higher order oligomers. Interacts with the large RNA polymerase II subunit RPO21; the interaction is direct and serves to bridge RPO21 to the Elongin complex in a manner dependent on transcription stress. Interacts with RAD26.
messages: Nucleus
messages: Proteolytically cleaved by the proteasome in response to transcription stress; the resulting N-terminal form constitutes the activated nuclear form and the C-terminal portion is degraded.
messages: Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled repair (TCR) factor RAD26 fails to efficiently displace stalled RNA polymerase II. Also involved in telomere length regulation. Binds DNA.
messages: Ubiquitinated.
messages: telomere

284811:AGOS AEL034W
gene id: 284811:AGOS_AEL034W
uniprot id: Q757P6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

284811:AGOS AEL140C
gene id: 284811:AGOS_AEL140C
uniprot id: Q758A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

284811:AGOS AGL192W
gene id: 284811:AGOS_AGL192W
uniprot id: Q750Y1
names: Similarity
messages: Belongs to the peptidase A1 family.

284811:AGOS AGR123C
gene id: 284811:AGOS_AGR123C
uniprot id: Q74ZS5
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AEL126W
gene id: 284811:AGOS_AEL126W
uniprot id: Q757Y6
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADR269C
gene id: 284811:AGOS_ADR269C
uniprot id: Q75A15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Mitochondrion inner membrane

284811:AGOS AAR136W
gene id: 284811:AGOS_AAR136W
uniprot id: Q75EE5
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AGL004C
gene id: 284811:AGOS_AGL004C
uniprot id: Q750F8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
messages: Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
messages: Component of pre-60S ribosomal complexes.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

284811:AGOS AAL108C
gene id: 284811:AGOS_AAL108C
uniprot id: Q75F36
names: Function
messages: Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

284811:AGOS AER032W
gene id: 284811:AGOS_AER032W
uniprot id: Q757I1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

284811:AGOS ADR207C
gene id: 284811:AGOS_ADR207C
uniprot id: Q759R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ING family.
messages: Nucleus

284811:AGOS AGL158C
gene id: 284811:AGOS_AGL158C
uniprot id: Q750U7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

284811:AGOS AFR205C
gene id: 284811:AGOS_AFR205C
uniprot id: Q753W7
names: Similarity
messages: Belongs to the protein kinase superfamily.

284811:AGOS AGL324W
gene id: 284811:AGOS_AGL324W
uniprot id: Q751M1
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ACR244C
gene id: 284811:AGOS_ACR244C
uniprot id: Q75BM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

284811:AGOS AFR629W
gene id: 284811:AGOS_AFR629W
uniprot id: Q752E7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Mitochondrion

284811:AGOS AFL159W
gene id: 284811:AGOS_AFL159W
uniprot id: Q755I2
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

284811:AGOS ACR226W
gene id: 284811:AGOS_ACR226W
uniprot id: Q75BP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Required both for recombination and for the repair of DNA damage caused by X-rays.

284811:AGOS AER189W
gene id: 284811:AGOS_AER189W
uniprot id: Q756R5
names: Similarity
messages: Belongs to the peptidase M28 family.

284811:AGOS AFR602W
gene id: 284811:AGOS_AFR602W
uniprot id: Q752H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

284811:AGOS AGR077C
gene id: 284811:AGOS_AGR077C
uniprot id: Q74ZY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

284811:AGOS AFR335C
gene id: 284811:AGOS_AFR335C
uniprot id: Q753H7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

284811:AGOS ACL043W
gene id: 284811:AGOS_ACL043W
uniprot id: Q75CG2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

284811:AGOS AER126W
gene id: 284811:AGOS_AER126W
uniprot id: Q756Y8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S) (By similarity).
messages: Mitochondrion

284811:AGOS AGL367WA
gene id: 284811:AGOS_AGL367WA
uniprot id: Q751Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase protein 8 family.
messages: Membrane

284811:AGOS ADL225W
gene id: 284811:AGOS_ADL225W
uniprot id: Q75AZ5
names: Similarity
messages: Belongs to the glycosyl hydrolase 15 family.

284811:AGOS AEL141W
gene id: 284811:AGOS_AEL141W
uniprot id: Q758A1
names: Similarity
messages: Belongs to the UPF0508 family.

284811:AGOS ADR070W
gene id: 284811:AGOS_ADR070W
uniprot id: Q75A49
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ADL336C
gene id: 284811:AGOS_ADL336C
uniprot id: Q75BA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM3 family.
messages: Membrane raft

284811:AGOS AAR175C
gene id: 284811:AGOS_AAR175C
uniprot id: Q75EA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MON1/SAND family.
messages: In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.
messages: Prevacuolar compartment membrane
messages: Vacuole membrane
messages: multivesicular body membrane

284811:AGOS ABL001W
gene id: 284811:AGOS_ABL001W
uniprot id: Q75DL8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

284811:AGOS AGR362C
gene id: 284811:AGOS_AGR362C
uniprot id: Q74Z44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

284811:AGOS AGL123W
gene id: 284811:AGOS_AGL123W
uniprot id: Q750R5
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

284811:AGOS ACR174C
gene id: 284811:AGOS_ACR174C
uniprot id: Q75BU7
names: Similarity
messages: Belongs to the TIP41 family.

284811:AGOS AAL186W
gene id: 284811:AGOS_AAL186W
uniprot id: Q75FB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AGR212W
gene id: 284811:AGOS_AGR212W
uniprot id: Q74ZJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm

284811:AGOS AFR633W
gene id: 284811:AGOS_AFR633W
uniprot id: Q752E3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

284811:AGOS AEL274C
gene id: 284811:AGOS_AEL274C
uniprot id: Q758M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

284811:AGOS AER178W
gene id: 284811:AGOS_AER178W
uniprot id: Q756S6
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

284811:AGOS ADR204W
gene id: 284811:AGOS_ADR204W
uniprot id: Q759R9
names: Similarity
messages: Belongs to the protein kinase superfamily.

284811:AGOS ACR260W
gene id: 284811:AGOS_ACR260W
uniprot id: Q75BL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS AER354W
gene id: 284811:AGOS_AER354W
uniprot id: Q756B3
names: Similarity
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

284811:AGOS ACL011C
gene id: 284811:AGOS_ACL011C
uniprot id: Q75CC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM34 family.
messages: Mitochondrion membrane

284811:AGOS AER028C
gene id: 284811:AGOS_AER028C
uniprot id: Q757I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

284811:AGOS AGL030W
gene id: 284811:AGOS_AGL030W
uniprot id: Q750I1
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

284811:AGOS AGR116W
gene id: 284811:AGOS_AGR116W
uniprot id: Q74ZT2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

284811:AGOS AER278W
gene id: 284811:AGOS_AER278W
uniprot id: Q756I3
names: Similarity
messages: Belongs to the SAP30 family.

284811:AGOS AAL053C
gene id: 284811:AGOS_AAL053C
uniprot id: Q75EY1
names: Function
messages: Cleaves A-5'-PPP-5'A to yield AMP and ADP. Can cleave all dinucleoside polyphosphates, provided the phosphate chain contains at least 3 phosphates and that 1 of the 2 bases composing the nucleotide is a purine. Is most effective on dinucleoside triphosphates. Negatively regulates intracellular dinucleoside polyphosphate levels, which elevate following heat shock.

284811:AGOS AGR136W
gene id: 284811:AGOS_AGR136W
uniprot id: Q74ZR2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic subunit of the histone H2A phosphatase complex (HTP-C) containing PPH3, PSY2 and PSY4.
messages: Cytoplasm
messages: Involved in the dephosphorylation and activation of the transcription factor GLN3 in response to nutrient availability. Forms the histone H2A phosphatase complex in association with the regulatory subunits PSY2 and PSY4, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).
messages: Nucleus

284811:AGOS AER241W
gene id: 284811:AGOS_AER241W
uniprot id: Q756L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPC110 family.
messages: Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Potential role in cross-linking filaments or anchoring other molecules. It is essential for growth (By similarity).
messages: Homodimer.
messages: Nucleus
messages: spindle pole body

284811:AGOS AEL297W
gene id: 284811:AGOS_AEL297W
uniprot id: Q758Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

284811:AGOS ADL113C
gene id: 284811:AGOS_ADL113C
uniprot id: Q75AN5
names: Similarity
messages: Belongs to the complex I LYR family.

284811:AGOS AFR625C
gene id: 284811:AGOS_AFR625C
uniprot id: Q752F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

284811:AGOS ABL040W
gene id: 284811:AGOS_ABL040W
uniprot id: Q75DQ7
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AGR155C
gene id: 284811:AGOS_AGR155C
uniprot id: Q74ZP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

284811:AGOS ABR050W
gene id: 284811:AGOS_ABR050W
uniprot id: Q75DR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CLU family.
messages: Cytoplasm
messages: May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.

284811:AGOS ADL255C
gene id: 284811:AGOS_ADL255C
uniprot id: Q75B32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer; composed of two copies of TRM6 and two copies of TRM61.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

284811:AGOS ADL223W
gene id: 284811:AGOS_ADL223W
uniprot id: Q75AZ3
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Octamer of two non-identical subunits IDH1 and IDH2.

284811:AGOS AEL098W
gene id: 284811:AGOS_AEL098W
uniprot id: Q757W0
names: Similarity
messages: Belongs to the AB hydrolase superfamily. MetX family.

284811:AGOS AEL136C
gene id: 284811:AGOS_AEL136C
uniprot id: Q757Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASP family.
messages: Golgi apparatus membrane
messages: Membrane

284811:AGOS AFR716C
gene id: 284811:AGOS_AFR716C
uniprot id: Q751V9
names: Similarity
messages: Belongs to the hexokinase family.

284811:AGOS AFR271W
gene id: 284811:AGOS_AFR271W
uniprot id: Q753P1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

284811:AGOS AGR076C
gene id: 284811:AGOS_AGR076C
uniprot id: Q74ZY2
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADL153W
gene id: 284811:AGOS_ADL153W
uniprot id: Q75AS3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a COP9 signalosome-like (CSN) complex.
messages: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response (By similarity).
messages: Cytoplasm
messages: Nucleus

284811:AGOS AFR563C
gene id: 284811:AGOS_AFR563C
uniprot id: Q752L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

284811:AGOS AER381C
gene id: 284811:AGOS_AER381C
uniprot id: Q755Y6
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

284811:AGOS AAR172W
gene id: 284811:AGOS_AAR172W
uniprot id: Q75EA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
messages: Forms a heterodimer with SLX4.
messages: Nucleus

284811:AGOS AAR168C
gene id: 284811:AGOS_AAR168C
uniprot id: Q75EA9
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

284811:AGOS AGL311C
gene id: 284811:AGOS_AGL311C
uniprot id: Q751L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS AFR015W
gene id: 284811:AGOS_AFR015W
uniprot id: Q754Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: Endoplasmic reticulum membrane
messages: May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.

284811:AGOS AFR511C
gene id: 284811:AGOS_AFR511C
uniprot id: Q752R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

284811:AGOS ADL049W
gene id: 284811:AGOS_ADL049W
uniprot id: Q75AH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids (By similarity).
messages: Mitochondrion inner membrane

284811:AGOS AFR283W
gene id: 284811:AGOS_AFR283W
uniprot id: Q753M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG32 family.
messages: Mitochondrion outer membrane
messages: Mitophagy-specific receptor that recruits the autophagic machinery to mitochondria and regulates selective degradation of mitochondria. Mitophagy contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Recruits ATG11 to the surface of mitochondria. Promotes also autophagy-dependent peroxisome degradation (By similarity).
messages: Preautophagosomal structure membrane
messages: Vacuole membrane

284811:AGOS AGL092W
gene id: 284811:AGOS_AGL092W
uniprot id: Q751B1
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

284811:AGOS ABR121C
gene id: 284811:AGOS_ABR121C
uniprot id: Q75DA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity).
messages: nucleolus

284811:AGOS AER234W
gene id: 284811:AGOS_AER234W
uniprot id: Q756M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

284811:AGOS AER363W
gene id: 284811:AGOS_AER363W
uniprot id: Q756A4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

284811:AGOS ADL285C
gene id: 284811:AGOS_ADL285C
uniprot id: Q75B57
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

284811:AGOS AEL044W
gene id: 284811:AGOS_AEL044W
uniprot id: Q757Q6
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

284811:AGOS ABL099W
gene id: 284811:AGOS_ABL099W
uniprot id: Q75DX2
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ADR164C
gene id: 284811:AGOS_ADR164C
uniprot id: Q759V8
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

284811:AGOS ABL063C
gene id: 284811:AGOS_ABL063C
uniprot id: Q75DT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPS2 family.
messages: Cell membrane
messages: Membrane

284811:AGOS ADR272W
gene id: 284811:AGOS_ADR272W
uniprot id: Q759K5
names: Subcellular Location Annotation
messages: nuclear pore complex

284811:AGOS ACR261C
gene id: 284811:AGOS_ACR261C
uniprot id: Q75BL0
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AGL138C
gene id: 284811:AGOS_AGL138C
uniprot id: Q750S7
names: Similarity
messages: Belongs to the peptidase M16 family.

284811:AGOS AEL289W
gene id: 284811:AGOS_AEL289W
uniprot id: Q758P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

284811:AGOS ABL190W
gene id: 284811:AGOS_ABL190W
uniprot id: Q75E60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SSU72 phosphatase family.
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs (By similarity).
messages: Component of the cleavage and polyadenylation factor (CPF) complex.
messages: Nucleus
messages: Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).

284811:AGOS AAR183C
gene id: 284811:AGOS_AAR183C
uniprot id: Q75ED3
names: Similarity
messages: Belongs to the MNN1/MNT family.

284811:AGOS ADR410C
gene id: 284811:AGOS_ADR410C
uniprot id: Q758W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-22 family.
messages: Involved in peroxisome biogenesis.
messages: Peroxisome membrane

284811:AGOS ABR227C
gene id: 284811:AGOS_ABR227C
uniprot id: Q75CZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Mitochondrion

284811:AGOS AGR032W
gene id: 284811:AGOS_AGR032W
uniprot id: Q750K9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLT11 family.
messages: Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity).
messages: Nucleus

284811:AGOS AGR075W
gene id: 284811:AGOS_AGR075W
uniprot id: Q74ZY3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

284811:AGOS ADR391W
gene id: 284811:AGOS_ADR391W
uniprot id: Q758Y6
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ACL201W
gene id: 284811:AGOS_ACL201W
uniprot id: Q75CW7
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

284811:AGOS ACL046C
gene id: 284811:AGOS_ACL046C
uniprot id: Q75CG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDA2 family.
messages: Cell projection
messages: Cytoplasm

284811:AGOS AFR131C
gene id: 284811:AGOS_AFR131C
uniprot id: Q754D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS ADL016C
gene id: 284811:AGOS_ADL016C
uniprot id: Q75AD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EST3 family.
messages: Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase (By similarity).
messages: Component of the telomerase complex.
messages: Nucleus
messages: telomere

284811:AGOS ABR103C
gene id: 284811:AGOS_ABR103C
uniprot id: Q75DC3
names: Similarity
messages: Belongs to the PHF5 family.

284811:AGOS AGR357W
gene id: 284811:AGOS_AGR357W
uniprot id: Q74Z49
names: Similarity
messages: Belongs to the asparaginase 1 family.

284811:AGOS ABR223C
gene id: 284811:AGOS_ABR223C
uniprot id: Q75CZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

284811:AGOS AGR248C
gene id: 284811:AGOS_AGR248C
uniprot id: Q74ZF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 22 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS ACL059C
gene id: 284811:AGOS_ACL059C
uniprot id: Q75CH8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

284811:AGOS AGL046C
gene id: 284811:AGOS_AGL046C
uniprot id: Q750J7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Component of the GSE complex.
messages: GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.

284811:AGOS AGL087C
gene id: 284811:AGOS_AGL087C
uniprot id: Q750N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

284811:AGOS AGR261W
gene id: 284811:AGOS_AGR261W
uniprot id: Q74ZD8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

284811:AGOS AFL175C
gene id: 284811:AGOS_AFL175C
uniprot id: Q755J8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROT1 family.
messages: Endoplasmic reticulum membrane
messages: Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies (By similarity).

284811:AGOS ABL036C
gene id: 284811:AGOS_ABL036C
uniprot id: Q75DQ3
names: Function
messages: Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).

284811:AGOS AER204W
gene id: 284811:AGOS_AER204W
uniprot id: Q756Q0
names: Similarity
messages: Belongs to the RENT3 family.

284811:AGOS AFR163C
gene id: 284811:AGOS_AFR163C
uniprot id: Q754A9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

284811:AGOS AFR687W
gene id: 284811:AGOS_AFR687W
uniprot id: Q751Y8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms a complex with MEC1.
messages: Forms a complex with the serine/threonine kinase MEC1 which activates checkpoint signaling upon genotoxic stresses. The MEC1-LCD1 complex is recruited to DNA lesions in order to initiates the DNA repair by homologous recombination. Required for cell growth and meiotic recombination (By similarity).
messages: Nucleus

284811:AGOS AFR491W
gene id: 284811:AGOS_AFR491W
uniprot id: Q752T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

284811:AGOS ABR108C
gene id: 284811:AGOS_ABR108C
uniprot id: Q75DB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombination (By similarity).

284811:AGOS AGR399C
gene id: 284811:AGOS_AGR399C
uniprot id: Q74Z08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

284811:AGOS AFR022C
gene id: 284811:AGOS_AFR022C
uniprot id: Q754Q0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

284811:AGOS AFL163C
gene id: 284811:AGOS_AFL163C
uniprot id: Q755I6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

284811:AGOS AFR160C
gene id: 284811:AGOS_AFR160C
uniprot id: Q754H5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Vacuole membrane

284811:AGOS AFL203C
gene id: 284811:AGOS_AFL203C
uniprot id: Q755L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVF1 family.
messages: Cytoplasm
messages: May be involved in the response to oxidative stress.
messages: Nucleus

284811:AGOS AFR584C
gene id: 284811:AGOS_AFR584C
uniprot id: Q752J1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

284811:AGOS AAR173C
gene id: 284811:AGOS_AAR173C
uniprot id: Q75EA4
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

284811:AGOS AEL314W
gene id: 284811:AGOS_AEL314W
uniprot id: Q758R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat MDV1/CAF4 family.
messages: Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division (By similarity).
messages: Mitochondrion outer membrane

284811:AGOS ADR099C
gene id: 284811:AGOS_ADR099C
uniprot id: Q75A21
names: Similarity
messages: Belongs to the PPP phosphatase family.

284811:AGOS ABL035C
gene id: 284811:AGOS_ABL035C
uniprot id: Q75DQ2
names: Similarity
messages: Belongs to the peptidase M18 family.

284811:AGOS AGL043C
gene id: 284811:AGOS_AGL043C
uniprot id: Q750J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

284811:AGOS AFR596W
gene id: 284811:AGOS_AFR596W
uniprot id: Q752H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity).
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

284811:AGOS AFR110C
gene id: 284811:AGOS_AFR110C
uniprot id: Q754G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
messages: Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
messages: Endoplasmic reticulum membrane

284811:AGOS ADL077C
gene id: 284811:AGOS_ADL077C
uniprot id: Q75AK4
names: Similarity
messages: Belongs to the RutC family.

284811:AGOS AER064C
gene id: 284811:AGOS_AER064C
uniprot id: Q757E9
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

284811:AGOS AEL052W
gene id: 284811:AGOS_AEL052W
uniprot id: Q757R4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF5 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

284811:AGOS AGL284C
gene id: 284811:AGOS_AGL284C
uniprot id: Q751J0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

284811:AGOS AGR053W
gene id: 284811:AGOS_AGR053W
uniprot id: Q750A4
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication.
messages: Heterotetramer. Consists of four subunits: POL2, DPB2, DPB3 and DPB4 (By similarity).
messages: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
messages: Nucleus

284811:AGOS ADR024W
gene id: 284811:AGOS_ADR024W
uniprot id: Q75A94
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

284811:AGOS AAL183W
gene id: 284811:AGOS_AAL183W
uniprot id: Q75FB4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AFR127W
gene id: 284811:AGOS_AFR127W
uniprot id: Q754E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

284811:AGOS AEL019W
gene id: 284811:AGOS_AEL019W
uniprot id: Q757L9
names: Similarity
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

284811:AGOS AAR064W
gene id: 284811:AGOS_AAR064W
uniprot id: Q75EL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M76 family.
messages: Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring (By similarity).
messages: Mitochondrion inner membrane

284811:AGOS AAR096W
gene id: 284811:AGOS_AAR096W
uniprot id: Q75EI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

284811:AGOS AFR230C
gene id: 284811:AGOS_AFR230C
uniprot id: Q753U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

284811:AGOS ADR330W
gene id: 284811:AGOS_ADR330W
uniprot id: Q759E7
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ABR133W
gene id: 284811:AGOS_ABR133W
uniprot id: Q75D91
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

284811:AGOS ACR207W
gene id: 284811:AGOS_ACR207W
uniprot id: Q75BR4
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

284811:AGOS AEL112C
gene id: 284811:AGOS_AEL112C
uniprot id: Q757X4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

284811:AGOS AEL286C
gene id: 284811:AGOS_AEL286C
uniprot id: Q758P1
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

284811:AGOS AER047C
gene id: 284811:AGOS_AER047C
uniprot id: Q757G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
messages: Cytoplasm
messages: Nucleus

284811:AGOS ACR111C
gene id: 284811:AGOS_ACR111C
uniprot id: Q75C08
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

284811:AGOS ACL032C
gene id: 284811:AGOS_ACL032C
uniprot id: Q75CF2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

284811:AGOS AGR384C
gene id: 284811:AGOS_AGR384C
uniprot id: Q74Z22
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

284811:AGOS AGR029W
gene id: 284811:AGOS_AGR029W
uniprot id: Q750C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

284811:AGOS ADR408W
gene id: 284811:AGOS_ADR408W
uniprot id: Q758X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Endoplasmic reticulum
messages: Microsome

284811:AGOS AGL188W
gene id: 284811:AGOS_AGL188W
uniprot id: Q750X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
messages: Cytoplasm
messages: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
messages: Nucleus

284811:AGOS AGL036C
gene id: 284811:AGOS_AGL036C
uniprot id: Q750I7
names: Similarity
messages: Belongs to the ClpA/ClpB family.

284811:AGOS ACL060C
gene id: 284811:AGOS_ACL060C
uniprot id: Q75CH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Nucleus
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.

284811:AGOS AFR048W
gene id: 284811:AGOS_AFR048W
uniprot id: Q754M4
names: Similarity
messages: Belongs to the arginase family.

284811:AGOS ABR231W
gene id: 284811:AGOS_ABR231W
uniprot id: Q75CZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YSP2 family.
messages: Membrane

284811:AGOS AEL127C
gene id: 284811:AGOS_AEL127C
uniprot id: Q757Y7
names: Function
names: Similarity
messages: Belongs to the LST4 family.
messages: Involved in extracellular amino acid uptake. Required for the protein trafficking from the Golgi to the plasma membrane (By similarity).

284811:AGOS AEL163C
gene id: 284811:AGOS_AEL163C
uniprot id: Q758B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Mitochondrion inner membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

284811:AGOS AFR030C
gene id: 284811:AGOS_AFR030C
uniprot id: Q754P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IBD2 family.
messages: Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis.
messages: spindle pole

284811:AGOS ADR233W
gene id: 284811:AGOS_ADR233W
uniprot id: Q759P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WHI5/NRM1 family.
messages: Cytoplasm
messages: Nucleus

284811:AGOS ABR192W
gene id: 284811:AGOS_ABR192W
uniprot id: Q75D31
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

284811:AGOS AAR160W
gene id: 284811:AGOS_AAR160W
uniprot id: Q75EB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Preautophagosomal structure membrane
messages: Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).

284811:AGOS AFR664W
gene id: 284811:AGOS_AFR664W
uniprot id: Q752B1
names: Similarity
messages: Belongs to the IST1 family.

284811:AGOS AFR705W
gene id: 284811:AGOS_AFR705W
uniprot id: Q751X0
names: Similarity
messages: Belongs to the RRP7 family.

284811:AGOS ACR028C
gene id: 284811:AGOS_ACR028C
uniprot id: Q75C88
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AFR363W
gene id: 284811:AGOS_AFR363W
uniprot id: Q753F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the ISY1 family.
messages: Cytoplasm
messages: Involved in nuclear pre-mRNA splicing.
messages: Nucleus

284811:AGOS ACR049W
gene id: 284811:AGOS_ACR049W
uniprot id: Q75C67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Nucleus

284811:AGOS ABL041W
gene id: 284811:AGOS_ABL041W
uniprot id: Q75DQ8
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

284811:AGOS AEL168C
gene id: 284811:AGOS_AEL168C
uniprot id: Q758C0
names: Subcellular Location Annotation
messages: nuclear pore complex

284811:AGOS AER109W
gene id: 284811:AGOS_AER109W
uniprot id: Q757A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cell membrane

284811:AGOS AEL064C
gene id: 284811:AGOS_AEL064C
uniprot id: Q757S6
names: Similarity
messages: Belongs to the PET191 family.

284811:AGOS AFR109W
gene id: 284811:AGOS_AFR109W
uniprot id: Q754G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

284811:AGOS AER217W
gene id: 284811:AGOS_AER217W
uniprot id: Q756N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

284811:AGOS AAL065C
gene id: 284811:AGOS_AAL065C
uniprot id: Q75EZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).
messages: Mitochondrion
messages: Mitochondrion inner membrane

284811:AGOS ACL108C
gene id: 284811:AGOS_ACL108C
uniprot id: Q75CM7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YPT35 family.
messages: Endosome membrane
messages: Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.
messages: The PX domain binds phosphatidylinositol 3-phosphate (PtdIns(3)P) which is necessary for peripheral membrane localization.
messages: Vacuole membrane

284811:AGOS ACR005W
gene id: 284811:AGOS_ACR005W
uniprot id: Q75CA7
names: Similarity
messages: Belongs to the SGT family.

284811:AGOS AGL285C
gene id: 284811:AGOS_AGL285C
uniprot id: Q751J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

284811:AGOS AER086C
gene id: 284811:AGOS_AER086C
uniprot id: Q757C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LOT5 family.
messages: Cytoplasm
messages: Nucleus

284811:AGOS AGR215C
gene id: 284811:AGOS_AGR215C
uniprot id: Q74ZI7
names: Subcellular Location Annotation
messages: Peroxisome membrane

284811:AGOS AAR090W
gene id: 284811:AGOS_AAR090W
uniprot id: Q75EI9
names: Similarity
messages: Belongs to the TEL2 family.

284811:AGOS AFR013C
gene id: 284811:AGOS_AFR013C
uniprot id: Q754Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: Homohexamer or homoheptamer. Organized in a ring with a central cavity.
messages: Mitochondrion matrix

284811:AGOS ADR217C
gene id: 284811:AGOS_ADR217C
uniprot id: Q759Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex DAD2 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
messages: Nucleus
messages: The DASH complex oligomerizes to form rings that encircle the microtubules.
messages: kinetochore
messages: spindle

284811:AGOS AFR069C
gene id: 284811:AGOS_AFR069C
uniprot id: Q754K3
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ABR045W
gene id: 284811:AGOS_ABR045W
uniprot id: Q75DI0
names: Similarity
messages: Belongs to the NifU family.

284811:AGOS AER306C
gene id: 284811:AGOS_AER306C
uniprot id: Q756F4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAD52 family.
messages: Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase (By similarity).
messages: Nucleus
messages: Part of a complex that includes RAD51, RAD52 and RAD59.

284811:AGOS AEL262CA
gene id: 284811:AGOS_AEL262CA
uniprot id: Q758M3
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ABL052C
gene id: 284811:AGOS_ABL052C
uniprot id: Q75DS8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Mitochondrion
messages: Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

284811:AGOS AGR343W
gene id: 284811:AGOS_AGR343W
uniprot id: Q74Z63
names: Similarity
messages: Belongs to the MIP18 family.

284811:AGOS AGL354C
gene id: 284811:AGOS_AGL354C
uniprot id: Q751P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

284811:AGOS AGL174W
gene id: 284811:AGOS_AGL174W
uniprot id: Q750W3
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RKM5 family.
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates 60S ribosomal protein L1.

284811:AGOS ABL161C
gene id: 284811:AGOS_ABL161C
uniprot id: Q75E31
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion

284811:AGOS AFR450C
gene id: 284811:AGOS_AFR450C
uniprot id: Q752X3
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

284811:AGOS ADL271W
gene id: 284811:AGOS_ADL271W
uniprot id: Q75B48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Component of the mitochondrial small ribosomal subunit.
messages: Involved in mitochondrial genome encoded proteins translation.
messages: Mitochondrion

284811:AGOS AFR263C
gene id: 284811:AGOS_AFR263C
uniprot id: Q753P9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs (By similarity). In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation (PubMed:26101253). Specifically degrades pre-mRNAs with a defective m7G cap and is part of a pre-mRNA capping quality control (PubMed:26101253). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (By similarity). Also has 5'-3' exonuclease activity (PubMed:26101253). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (PubMed:26101253).
messages: Divalent metal cation.
messages: Nucleus

284811:AGOS AGL337C
gene id: 284811:AGOS_AGL337C
uniprot id: Q751N4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

284811:AGOS ADL321W
gene id: 284811:AGOS_ADL321W
uniprot id: Q75B91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex.
messages: Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity).
messages: secretory vesicle

284811:AGOS AGR268W
gene id: 284811:AGOS_AGR268W
uniprot id: Q74ZD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIT family.
messages: Cytoplasm

284811:AGOS AGR354W
gene id: 284811:AGOS_AGR354W
uniprot id: Q74Z52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP10 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.
messages: nucleolus

284811:AGOS AGR129C
gene id: 284811:AGOS_AGR129C
uniprot id: Q74ZR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

284811:AGOS ABR058C
gene id: 284811:AGOS_ABR058C
uniprot id: Q75DG8
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AFL207C
gene id: 284811:AGOS_AFL207C
uniprot id: Q755M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

284811:AGOS AFR685C
gene id: 284811:AGOS_AFR685C
uniprot id: Q751Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRM1 family.
messages: Cell membrane
messages: Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.

284811:AGOS AER082W
gene id: 284811:AGOS_AER082W
uniprot id: Q757D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytoskeleton

284811:AGOS AFL165W
gene id: 284811:AGOS_AFL165W
uniprot id: Q755I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC4 family.
messages: Mitochondrion intermembrane space

284811:AGOS AEL279C
gene id: 284811:AGOS_AEL279C
uniprot id: Q758N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Nucleus

284811:AGOS ACL012W
gene id: 284811:AGOS_ACL012W
uniprot id: Q75CC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Mitochondrion inner membrane
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).

284811:AGOS AFR034W
gene id: 284811:AGOS_AFR034W
uniprot id: Q754N8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

284811:AGOS AAR105W
gene id: 284811:AGOS_AAR105W
uniprot id: Q75EH4
names: Subcellular Location Annotation
messages: Nucleus membrane

284811:AGOS ACR052W
gene id: 284811:AGOS_ACR052W
uniprot id: Q75C64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

284811:AGOS ABR215C
gene id: 284811:AGOS_ABR215C
uniprot id: Q75D07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM11 family.
messages: Membrane

284811:AGOS AAR047C
gene id: 284811:AGOS_AAR047C
uniprot id: Q75EN2
names: Similarity
messages: Belongs to the pyridoxine kinase family.

284811:AGOS AGL310C
gene id: 284811:AGOS_AGL310C
uniprot id: Q751L1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

284811:AGOS AFR479W
gene id: 284811:AGOS_AFR479W
uniprot id: Q752U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPC1 family.
messages: Membrane

284811:AGOS ADR397C
gene id: 284811:AGOS_ADR397C
uniprot id: Q758Y1
names: Similarity
messages: Belongs to the BolA/IbaG family.

284811:AGOS ACR100C
gene id: 284811:AGOS_ACR100C
uniprot id: Q75C17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM41 family.
messages: Mitochondrion

284811:AGOS ADR031C
gene id: 284811:AGOS_ADR031C
uniprot id: Q75A87
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

284811:AGOS ADL230C
gene id: 284811:AGOS_ADL230C
uniprot id: Q75B07
names: Similarity
messages: Belongs to the SHQ1 family.

284811:AGOS ABR101C
gene id: 284811:AGOS_ABR101C
uniprot id: Q75DC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome.
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

284811:AGOS AEL254W
gene id: 284811:AGOS_AEL254W
uniprot id: Q758L5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

284811:AGOS AGL226C
gene id: 284811:AGOS_AGL226C
uniprot id: Q751D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 12 family.
messages: Component of the SRB8-11 complex, which itself associates with the Mediator complex.
messages: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
messages: Nucleus

284811:AGOS ACR151W
gene id: 284811:AGOS_ACR151W
uniprot id: Q75BX0
names: Subcellular Location Annotation
messages: Cytoplasm

284811:AGOS AEL024C
gene id: 284811:AGOS_AEL024C
uniprot id: Q757N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ECO subfamily.
messages: Nucleus
messages: Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by acetylating the cohesin complex component SMC3 (By similarity).

284811:AGOS AAR147W
gene id: 284811:AGOS_AAR147W
uniprot id: Q75EC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

284811:AGOS AFR304W
gene id: 284811:AGOS_AFR304W
uniprot id: Q753K8
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AER052W
gene id: 284811:AGOS_AER052W
uniprot id: Q757G1
names: Cofactor
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 1 zinc ion per subunit.

284811:AGOS AER351W
gene id: 284811:AGOS_AER351W
uniprot id: Q756B6
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

284811:AGOS AFL026W
gene id: 284811:AGOS_AFL026W
uniprot id: Q754U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: Nucleus
messages: Responsible for methylating the 5'-cap structure of mRNAs.

284811:AGOS ACR236W
gene id: 284811:AGOS_ACR236W
uniprot id: Q75BN5
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

284811:AGOS AGR335C
gene id: 284811:AGOS_AGR335C
uniprot id: Q74Z71
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

284811:AGOS ADL291W
gene id: 284811:AGOS_ADL291W
uniprot id: Q75B63
names: Similarity
messages: Belongs to the IWR1/SLC7A6OS family.

284811:AGOS AGL252W
gene id: 284811:AGOS_AGL252W
uniprot id: Q751F8
names: Function
names: Similarity
messages: Belongs to the VPS16 family.
messages: Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.

284811:AGOS ADL078C
gene id: 284811:AGOS_ADL078C
uniprot id: Q75AK5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

284811:AGOS ADR362C
gene id: 284811:AGOS_ADR362C
uniprot id: Q759B5
names: Function
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

284811:AGOS ABR099C
gene id: 284811:AGOS_ABR099C
uniprot id: Q75DC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

284811:AGOS AEL337C
gene id: 284811:AGOS_AEL337C
uniprot id: Q758T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Nucleus

284811:AGOS AFL124C
gene id: 284811:AGOS_AFL124C
uniprot id: Q755E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOT1 family.
messages: Nucleus
messages: Required for a complete transcriptional response to osmotic stress.

284811:AGOS ADL150C
gene id: 284811:AGOS_ADL150C
uniprot id: Q75AS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDA11 family.
messages: Cytoplasm

284811:AGOS AEL164C
gene id: 284811:AGOS_AEL164C
uniprot id: Q758B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
messages: Endoplasmic reticulum membrane

284811:AGOS ACL069C
gene id: 284811:AGOS_ACL069C
uniprot id: Q75CI8
names: Similarity
messages: Belongs to the FGGY kinase family.

284811:AGOS AGL295C
gene id: 284811:AGOS_AGL295C
uniprot id: Q751K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

284811:AGOS AER156C
gene id: 284811:AGOS_AER156C
uniprot id: Q756U6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

284811:AGOS ADR158W
gene id: 284811:AGOS_ADR158W
uniprot id: Q759W4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
messages: Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex (By similarity).
messages: Endoplasmic reticulum membrane
messages: The C-terminal short (CTS) helix is essential for catalytic activity. It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates.

284811:AGOS ACL008C
gene id: 284811:AGOS_ACL008C
uniprot id: Q75CB7
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

284811:AGOS AER069W
gene id: 284811:AGOS_AER069W
uniprot id: Q757E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

284811:AGOS ADL201W
gene id: 284811:AGOS_ADL201W
uniprot id: Q757K0
uniprot id: Q75AX1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).

284811:AGOS ACR171C
gene id: 284811:AGOS_ACR171C
uniprot id: Q75BV0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

284811:AGOS AFR497C
gene id: 284811:AGOS_AFR497C
uniprot id: Q752S6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWC4 family.
messages: Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
messages: Nucleus

284811:AGOS ACR134W
gene id: 284811:AGOS_ACR134W
uniprot id: Q75BY6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Required for methionine synthesis and maintenance of intact mitochondrial DNA. Involved in telomere maintenance.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix

284811:AGOS AGR201C
gene id: 284811:AGOS_AGR201C
uniprot id: Q74ZJ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

284811:AGOS ADR413C
gene id: 284811:AGOS_ADR413C
uniprot id: Q758W5
names: Function
names: Similarity
messages: Belongs to the Rab GDI family.
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

284811:AGOS AFR257W
gene id: 284811:AGOS_AFR257W
uniprot id: Q753R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

284811:AGOS AEL143W
gene id: 284811:AGOS_AEL143W
uniprot id: Q758A3
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AEL105W
gene id: 284811:AGOS_AEL105W
uniprot id: Q757W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S64 family.
messages: Cell membrane
messages: Component of the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor complex.
messages: Protease component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2. Catalyzes the activation of these transcription factors, which are synthesized as latent cytoplasmic precursors, by proteolytic removal of an N-terminal inhibitory domain containing cytoplasmic retention motifs. SSY5 binds as an inactive protease complex to STP1. In response to extracellular amino acids and dependent on the other SPS-sensor components, the inhibitory propeptide is induced to dissociate, and thereby enables the catalytic domain to process STP1.

284811:AGOS AFL204C
gene id: 284811:AGOS_AFL204C
uniprot id: Q755L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

284811:AGOS AFL142W
gene id: 284811:AGOS_AFL142W
uniprot id: Q755G5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).
messages: May form heterododecamers with RVB1. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).
messages: Nucleus

284811:AGOS ADR086C
gene id: 284811:AGOS_ADR086C
uniprot id: Q75A34
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing (By similarity).
messages: Following transcription stress, the elongating form of RNA polymerase II (RNA pol IIo) is polyubiquitinated via 'Lys-63'-linkages on Lys-1247 at DNA damage sites without leading to degradation: ubiquitination promotes RNA pol IIo backtracking to allow access by the transcription-coupled nucleotide excision repair (TC-NER) machinery. Subsequent DEF1-dependent polyubiquitination by the elongin complex via 'Lys-48'-linkages may lead to proteasome-mediated degradation; presumably at stalled RNA pol II where TC-NER has failed, to halt global transcription and enable 'last resort' DNA repair pathways.
messages: Nucleus
messages: The C-terminal domain (CTD) serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing.
messages: The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion temporarily coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits. The ribonucleoside triphosphate is transferred by a rotation to the nucleotide addition (A) site for pairing with the template DNA. The catalytic A site involves three conserved aspartate residues of the RNA Pol II largest subunit which permanently coordinate a second magnesium ion.
messages: The tandem 7 residues repeats in the C-terminal domain (CTD) can be highly phosphorylated. The phosphorylation activates Pol II. Phosphorylation occurs mainly at residues 'Ser-2' and 'Ser-5' of the heptapeptide repeat. The phosphorylation state is believed to result from the balanced action of site-specific CTD kinases and phosphatase, and a 'CTD code' that specifies the position of Pol II within the transcription cycle has been proposed (By similarity).

284811:AGOS ADL207W
gene id: 284811:AGOS_ADL207W
uniprot id: Q75AX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Component of the SRB8-11 complex, a regulatory module of the Mediator complex.
messages: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
messages: Nucleus

284811:AGOS ADR273C
gene id: 284811:AGOS_ADR273C
uniprot id: Q759K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NUR1 family.
messages: Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability. Required for rDNA repeat stability (By similarity).
messages: Nucleus membrane

284811:AGOS AGR402C
gene id: 284811:AGOS_AGR402C
uniprot id: Q74Z05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DCP1 family.
messages: Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body (By similarity).
messages: Component of the decapping complex.
messages: P-body

284811:AGOS ACR060W
gene id: 284811:AGOS_ACR060W
uniprot id: Q75C56
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

284811:AGOS ABL045W
gene id: 284811:AGOS_ABL045W
uniprot id: Q75DR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLD2 family.
messages: Cytoplasm
messages: Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity).
messages: Nucleus

284811:AGOS AEL031C
gene id: 284811:AGOS_AEL031C
uniprot id: Q757P3
names: Similarity
messages: Belongs to the RNR ribonuclease family.

284811:AGOS ADR293C
gene id: 284811:AGOS_ADR293C
uniprot id: Q759H2
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AER053C
gene id: 284811:AGOS_AER053C
uniprot id: Q757G0
names: Similarity
messages: Belongs to the peptidase M16 family.

284811:AGOS AGR302C
gene id: 284811:AGOS_AGR302C
uniprot id: Q74ZA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

284811:AGOS ACR185W
gene id: 284811:AGOS_ACR185W
uniprot id: Q75BT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

284811:AGOS AAL148W
gene id: 284811:AGOS_AAL148W
uniprot id: Q75F76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

284811:AGOS AGL307W
gene id: 284811:AGOS_AGL307W
uniprot id: Q751K8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus
messages: Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase.

284811:AGOS AAR094W
gene id: 284811:AGOS_AAR094W
uniprot id: Q75EI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome.
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

284811:AGOS ADL062W
gene id: 284811:AGOS_ADL062W
uniprot id: Q75AI9
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the NAGSA dehydrogenase family.
messages: In the N-terminal section; belongs to the acetylglutamate kinase family.
messages: Mitochondrion

284811:AGOS ADL377W
gene id: 284811:AGOS_ADL377W
uniprot id: Q75BE1
names: Similarity
messages: Belongs to the PP2C family.

284811:AGOS AGR321W
gene id: 284811:AGOS_AGR321W
uniprot id: Q74ZF7
names: Similarity
messages: Belongs to the MEMO1 family.

284811:AGOS AFR704W
gene id: 284811:AGOS_AFR704W
uniprot id: Q751X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

284811:AGOS ADL233W
gene id: 284811:AGOS_ADL233W
uniprot id: Q75B10
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Nucleus

284811:AGOS AER018C
gene id: 284811:AGOS_AER018C
uniprot id: Q757J5
names: Similarity
messages: Belongs to the MNN1/MNT family.

284811:AGOS AFR666C
gene id: 284811:AGOS_AFR666C
uniprot id: Q752A9
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

284811:AGOS AGL208C
gene id: 284811:AGOS_AGL208C
uniprot id: Q750Z5
names: Similarity
messages: Belongs to the glycosyl hydrolase 81 family.

284811:AGOS AAL006C
gene id: 284811:AGOS_AAL006C
uniprot id: Q75EU1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

284811:AGOS AFR245W
gene id: 284811:AGOS_AFR245W
uniprot id: Q753T1
names: Similarity
messages: Belongs to the SAPS family.

284811:AGOS AFL196W
gene id: 284811:AGOS_AFL196W
uniprot id: Q755L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS AEL057C
gene id: 284811:AGOS_AEL057C
uniprot id: Q757R9
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AGL288W
gene id: 284811:AGOS_AGL288W
uniprot id: Q751J4
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

284811:AGOS AFR282W
gene id: 284811:AGOS_AFR282W
uniprot id: Q753N0
names: Similarity
messages: Belongs to the pantothenate synthetase family.

284811:AGOS AAL021W
gene id: 284811:AGOS_AAL021W
uniprot id: Q75ET7
names: Similarity
messages: Belongs to the acetolactate synthase small subunit family.

284811:AGOS AEL045W
gene id: 284811:AGOS_AEL045W
uniprot id: Q757Q7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

284811:AGOS ABL091C
gene id: 284811:AGOS_ABL091C
uniprot id: Q75DW4
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

284811:AGOS AER135W
gene id: 284811:AGOS_AER135W
uniprot id: Q756X9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMA2 family.
messages: Involved in spore and ascus formation. Required for the efficient assembly of the precursors of the prospore membrane to a continuous prospore membrane (By similarity).
messages: Prospore membrane

284811:AGOS AAR127C
gene id: 284811:AGOS_AAR127C
uniprot id: Q75EF4
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ABL147W
gene id: 284811:AGOS_ABL147W
uniprot id: Q75E79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with snRNPs.
messages: Belongs to the SWT21 family.
messages: Involved in mRNA splicing. Helps to stabilize the U1 snRNP-5' splice site interaction (By similarity).
messages: Nucleus

284811:AGOS AFR203C
gene id: 284811:AGOS_AFR203C
uniprot id: Q753W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.
messages: Nucleus
messages: kinetochore

284811:AGOS AER179C
gene id: 284811:AGOS_AER179C
uniprot id: Q756S5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL19 family.

284811:AGOS ADR005W
gene id: 284811:AGOS_ADR005W
uniprot id: Q75AB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMP52 family.
messages: Mitochondrion outer membrane

284811:AGOS ABL076W
gene id: 284811:AGOS_ABL076W
uniprot id: Q75DU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM18/AIM46 family.
messages: Mitochondrion

284811:AGOS AGL140C
gene id: 284811:AGOS_AGL140C
uniprot id: Q750S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS35 family.
messages: Involved in mitochondrial genome encoded proteins translation.
messages: Mitochondrion

284811:AGOS AAR155W
gene id: 284811:AGOS_AAR155W
uniprot id: Q75EB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GEP7 family.
messages: Involved in respiratory growth and required for cell survival in the absence of prohibitins.
messages: Mitochondrion membrane

284811:AGOS ADL376W
gene id: 284811:AGOS_ADL376W
uniprot id: Q75BE0
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AFR105C
gene id: 284811:AGOS_AFR105C
uniprot id: Q754G5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP4 subfamily.
messages: Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex, of the INO80 chromatin remodeling complex, and of the SWR1 chromatin remodeling complex.
messages: Nucleus

284811:AGOS AGR205C
gene id: 284811:AGOS_AGR205C
uniprot id: Q74ZJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEN54 family.
messages: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. May be required to embody the molecular ruler of the complex (By similarity).
messages: tRNA splicing endonuclease is a heterotetramer composed of SEN2, SEN15, SEN34 and SEN54. Interacts directly with SEN2 (By similarity).

284811:AGOS AER250C
gene id: 284811:AGOS_AER250C
uniprot id: Q756K4
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

284811:AGOS AER383W
gene id: 284811:AGOS_AER383W
uniprot id: Q755Y4
names: Subcellular Location Annotation
messages: Vacuole

284811:AGOS AEL305C
gene id: 284811:AGOS_AEL305C
uniprot id: Q758Q8
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

284811:AGOS AGR089C
gene id: 284811:AGOS_AGR089C
uniprot id: Q74ZW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC4 subfamily.
messages: Nucleus

284811:AGOS ACR050C
gene id: 284811:AGOS_ACR050C
uniprot id: Q75C66
names: Similarity
messages: Belongs to the AAA ATPase family.

284811:AGOS ACR270W
gene id: 284811:AGOS_ACR270W
uniprot id: Q75BK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.
messages: Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body (By similarity).
messages: Component of the decapping complex.
messages: P-body

284811:AGOS AFR073C
gene id: 284811:AGOS_AFR073C
uniprot id: Q754J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Membrane

284811:AGOS AER292C
gene id: 284811:AGOS_AER292C
uniprot id: Q756H4
names: Similarity
messages: Belongs to the FMO family.

284811:AGOS AER364W
gene id: 284811:AGOS_AER364W
uniprot id: Q756A3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

284811:AGOS ADR332W
gene id: 284811:AGOS_ADR332W
uniprot id: Q759E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

284811:AGOS AFR671W
gene id: 284811:AGOS_AFR671W
uniprot id: Q752A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

284811:AGOS AEL144W
gene id: 284811:AGOS_AEL144W
uniprot id: Q758A4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GON7 family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators (By similarity).
messages: Nucleus
messages: telomere

284811:AGOS AAR030W
gene id: 284811:AGOS_AAR030W
uniprot id: Q75EP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

284811:AGOS ACL131W
gene id: 284811:AGOS_ACL131W
uniprot id: Q75CQ0
names: Similarity
messages: Belongs to the thioredoxin family.

284811:AGOS AEL309W
gene id: 284811:AGOS_AEL309W
uniprot id: Q758R2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS AFR145C
gene id: 284811:AGOS_AFR145C
uniprot id: Q754C5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

284811:AGOS ADL161C
gene id: 284811:AGOS_ADL161C
uniprot id: Q75AT1
names: Function
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

284811:AGOS AER061C
gene id: 284811:AGOS_AER061C
uniprot id: Q757F2
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

284811:AGOS AER456W
gene id: 284811:AGOS_AER456W
uniprot id: Q752D3
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AAR034W
gene id: 284811:AGOS_AAR034W
uniprot id: Q75EP5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

284811:AGOS AGL340C
gene id: 284811:AGOS_AGL340C
uniprot id: Q751R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Membrane

284811:AGOS AFR444C
gene id: 284811:AGOS_AFR444C
uniprot id: Q752X9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol (By similarity).
messages: Endoplasmic reticulum membrane

284811:AGOS ABL074C
gene id: 284811:AGOS_ABL074C
uniprot id: Q75DU7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM8 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

284811:AGOS ABR013W
gene id: 284811:AGOS_ABR013W
uniprot id: Q75DK8
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.

284811:AGOS ACR149C
gene id: 284811:AGOS_ACR149C
uniprot id: Q75BX2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

284811:AGOS AAL050W
gene id: 284811:AGOS_AAL050W
uniprot id: Q75EX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AFL036C
gene id: 284811:AGOS_AFL036C
uniprot id: Q754Z5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

284811:AGOS ADL013C
gene id: 284811:AGOS_ADL013C
uniprot id: Q75AD0
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

284811:AGOS AFR111C
gene id: 284811:AGOS_AFR111C
uniprot id: Q754F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

284811:AGOS AFR632C
gene id: 284811:AGOS_AFR632C
uniprot id: Q752E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RTC4 family.
messages: Cytoplasm
messages: May be involved in a process influencing telomere capping.
messages: Nucleus

284811:AGOS AAL046C
gene id: 284811:AGOS_AAL046C
uniprot id: Q75EX4
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

284811:AGOS ACL068W
gene id: 284811:AGOS_ACL068W
uniprot id: Q75CI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

284811:AGOS AEL165C
gene id: 284811:AGOS_AEL165C
uniprot id: Q758B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

284811:AGOS AEL246C
gene id: 284811:AGOS_AEL246C
uniprot id: Q758K7
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

284811:AGOS AGL325W
gene id: 284811:AGOS_AGL325W
uniprot id: Q751M2
names: Similarity
messages: Belongs to the peptidase M20A family.

284811:AGOS AGR065W
gene id: 284811:AGOS_AGR065W
uniprot id: Q74ZZ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. SWF1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Palmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins (By similarity).
messages: The DHHC domain is required for palmitoyltransferase activity.

284811:AGOS ACR045W
gene id: 284811:AGOS_ACR045W
uniprot id: Q75C71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

284811:AGOS ABL107C
gene id: 284811:AGOS_ABL107C
uniprot id: Q75DY0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethan group.

284811:AGOS AGL102W
gene id: 284811:AGOS_AGL102W
uniprot id: Q751B4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Endoplasmic reticulum membrane
messages: Functions as a zinc transporter.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

284811:AGOS AFL039C
gene id: 284811:AGOS_AFL039C
uniprot id: Q754Y9
names: Similarity
messages: Belongs to the glutathione peroxidase family.

284811:AGOS ACR106C
gene id: 284811:AGOS_ACR106C
uniprot id: Q75C11
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

284811:AGOS AGL189C
gene id: 284811:AGOS_AGL189C
uniprot id: Q750X8
names: Similarity
messages: Belongs to the VPS37 family.

284811:AGOS AGR091W
gene id: 284811:AGOS_AGR091W
uniprot id: Q74ZV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP6 subfamily.
messages: Component of the SWR1 chromatin remodeling complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: cytoskeleton

284811:AGOS ACL031C
gene id: 284811:AGOS_ACL031C
uniprot id: Q75CE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM9 family.
messages: Mitochondrion

284811:AGOS AER092W
gene id: 284811:AGOS_AER092W
uniprot id: Q757C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

284811:AGOS AEL109W
gene id: 284811:AGOS_AEL109W
uniprot id: Q757X1
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

284811:AGOS ADL260W
gene id: 284811:AGOS_ADL260W
uniprot id: Q75B37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Cytoplasm
messages: Putative tyrosine-protein phosphatase required for protection against superoxide stress.

284811:AGOS AGR185C
gene id: 284811:AGOS_AGR185C
uniprot id: Q74ZL3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May be involved in the control of meiotic sister-chromatid recombination.

284811:AGOS AEL324C
gene id: 284811:AGOS_AEL324C
uniprot id: Q758S6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

284811:AGOS ADR288W
gene id: 284811:AGOS_ADR288W
uniprot id: Q759I9
names: Similarity
messages: Belongs to the uridine kinase family.

284811:AGOS AFL212C
gene id: 284811:AGOS_AFL212C
uniprot id: Q755M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.
messages: Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.
messages: Cytoplasm
messages: P-body

284811:AGOS AER131C
gene id: 284811:AGOS_AER131C
uniprot id: Q756Y3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).
messages: Cytoplasm

284811:AGOS AGL055C
gene id: 284811:AGOS_AGL055C
uniprot id: Q750K6
names: Function
names: Similarity
messages: ATP-dependent kinase that could be involved in endoplasmic reticulum membrane assembly.
messages: Belongs to the YFH7 family.

284811:AGOS ADL213W
gene id: 284811:AGOS_ADL213W
uniprot id: Q75AY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

284811:AGOS ABL029W
gene id: 284811:AGOS_ABL029W
uniprot id: Q75DP6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

284811:AGOS AEL116C
gene id: 284811:AGOS_AEL116C
uniprot id: Q758E2
names: Subcellular Location Annotation
messages: Mitochondrion

284811:AGOS AEL055C
gene id: 284811:AGOS_AEL055C
uniprot id: Q757R7
names: Similarity
messages: Belongs to the TPP enzyme family.

284811:AGOS AAR170W
gene id: 284811:AGOS_AAR170W
uniprot id: Q75EA7
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

284811:AGOS AFR226C
gene id: 284811:AGOS_AFR226C
uniprot id: Q753U9
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

284811:AGOS AER254W
gene id: 284811:AGOS_AER254W
uniprot id: Q756K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

284811:AGOS AAR092W
gene id: 284811:AGOS_AAR092W
uniprot id: Q75EI7
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFL138W
gene id: 284811:AGOS_AFL138W
uniprot id: Q755G1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.

284811:AGOS ADL108C
gene id: 284811:AGOS_ADL108C
uniprot id: Q75AN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
messages: Belongs to the CNOT2/3/5 family.
messages: Cytoplasm
messages: Nucleus

284811:AGOS AFR424C
gene id: 284811:AGOS_AFR424C
uniprot id: Q753A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).

284811:AGOS AFR143C
gene id: 284811:AGOS_AFR143C
uniprot id: Q754C7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the VPS17 family.
messages: Component of the retromer complex.
messages: Plays a role in vesicular protein sorting.

284811:AGOS AFR355C
gene id: 284811:AGOS_AFR355C
uniprot id: Q753F9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

284811:AGOS ADL059C
gene id: 284811:AGOS_ADL059C
uniprot id: Q75AI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.

284811:AGOS AGL193W
gene id: 284811:AGOS_AGL193W
uniprot id: Q750Y2
names: Similarity
messages: Belongs to the cullin family.

284811:AGOS AAR024W
gene id: 284811:AGOS_AAR024W
uniprot id: Q75EQ5
names: Similarity
messages: Belongs to the MAPRE family.

284811:AGOS AEL218W
gene id: 284811:AGOS_AEL218W
uniprot id: Q758I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Chromosome
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
messages: Nucleus

284811:AGOS AAR095C
gene id: 284811:AGOS_AAR095C
uniprot id: Q75EI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS ABL059W
gene id: 284811:AGOS_ABL059W
uniprot id: Q75E82
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ACL103W
gene id: 284811:AGOS_ACL103W
uniprot id: Q75CM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP22 family.
messages: Mitochondrion inner membrane
messages: Translation factor specific for subunit 6 of the mitochondrial ATPase. Required for assembly of the CF(0) component of the ATPase (By similarity).

284811:AGOS ADR383C
gene id: 284811:AGOS_ADR383C
uniprot id: Q758Z4
names: Function
names: Subcellular Location Annotation
messages: May be involved in the control of meiotic sister-chromatid recombination.
messages: Mitochondrion

284811:AGOS ADR274C
gene id: 284811:AGOS_ADR274C
uniprot id: Q759K3
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase C2 family. PalB/RIM13 subfamily.
messages: Lacks the conserved Asn residue of the catalytic triad in position 292, which is replaced by an Asp residue.
messages: Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.

284811:AGOS AFR621C
gene id: 284811:AGOS_AFR621C
uniprot id: Q752F5
names: Similarity
messages: Belongs to the CDC6/cdc18 family.

284811:AGOS ADR256W
gene id: 284811:AGOS_ADR256W
uniprot id: Q759M0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

284811:AGOS AFL034W
gene id: 284811:AGOS_AFL034W
uniprot id: Q754V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

284811:AGOS ADL001C
gene id: 284811:AGOS_ADL001C
uniprot id: Q8J1F5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRC22 family.
messages: Endoplasmic reticulum membrane
messages: Is probably involved in a pathway contributing to genomic integrity.

284811:AGOS AER360C
gene id: 284811:AGOS_AER360C
uniprot id: Q756A7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity.
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
messages: Forms a stable heterodimer with POB3. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex (By similarity).
messages: Nucleus

284811:AGOS AGL283W
gene id: 284811:AGOS_AGL283W
uniprot id: Q751I9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M24 family.
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm

284811:AGOS AER420C
gene id: 284811:AGOS_AER420C
uniprot id: Q755U8
names: Similarity
messages: Belongs to the MAD2 family.

284811:AGOS ABR239C
gene id: 284811:AGOS_ABR239C
uniprot id: Q75CY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOS1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: SNARE required for protein transport between the ER and the Golgi complex.

284811:AGOS AER267W
gene id: 284811:AGOS_AER267W
uniprot id: Q756X2
names: Similarity
messages: In the C-terminal section; belongs to the anthranilate synthase component I family.

284811:AGOS AEL261C
gene id: 284811:AGOS_AEL261C
uniprot id: Q758M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: nucleolus

284811:AGOS AFR292W
gene id: 284811:AGOS_AFR292W
uniprot id: Q753M0
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

284811:AGOS ABR029W
gene id: 284811:AGOS_ABR029W
uniprot id: Q75DS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
messages: nucleolus

284811:AGOS ACR230C
gene id: 284811:AGOS_ACR230C
uniprot id: Q75BP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-13 family.
messages: Membrane
messages: Peroxisome membrane

284811:AGOS ADR095W
gene id: 284811:AGOS_ADR095W
uniprot id: Q75A25
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

284811:AGOS AAL142C
gene id: 284811:AGOS_AAL142C
uniprot id: Q75F70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBP4 family.
messages: Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b (By similarity).
messages: Mitochondrion inner membrane

284811:AGOS AER426C
gene id: 284811:AGOS_AER426C
uniprot id: Q755U2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

284811:AGOS ACR172W
gene id: 284811:AGOS_ACR172W
uniprot id: Q75BU9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
messages: Cytoplasm
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.

284811:AGOS AEL096W
gene id: 284811:AGOS_AEL096W
uniprot id: Q757V8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.
messages: nucleolus

284811:AGOS ACL024W
gene id: 284811:AGOS_ACL024W
uniprot id: Q75CD3
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

284811:AGOS AGR139C
gene id: 284811:AGOS_AGR139C
uniprot id: Q74ZQ9
names: Similarity
messages: Belongs to the peptidase C19 family.

284811:AGOS ADR312W
gene id: 284811:AGOS_ADR312W
uniprot id: Q759G4
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ACR290W
gene id: 284811:AGOS_ACR290W
uniprot id: Q75BI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

284811:AGOS AGR376W
gene id: 284811:AGOS_AGR376W
uniprot id: Q74Z30
names: Similarity
messages: Belongs to the AAR2 family.

284811:AGOS ACL176W
gene id: 284811:AGOS_ACL176W
uniprot id: Q75CU5
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

284811:AGOS ACR157C
gene id: 284811:AGOS_ACR157C
uniprot id: Q75BW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPC29 family.
messages: Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Links the central plaque component SPC42 to the inner plaque component SPC110 (By similarity).
messages: Nucleus
messages: spindle pole body

284811:AGOS AEL025W
gene id: 284811:AGOS_AEL025W
uniprot id: Q757N7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

284811:AGOS ADL031W
gene id: 284811:AGOS_ADL031W
uniprot id: Q75AE8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

284811:AGOS AAL067W
gene id: 284811:AGOS_AAL067W
uniprot id: Q75EZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL67 family.
messages: Mitochondrion
messages: Nucleus
messages: Transcription factor involved in regulation of RNA polymerase II-dependent transcription. Also involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells (By similarity).

284811:AGOS AGR395W
gene id: 284811:AGOS_AGR395W
uniprot id: Q74Z12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

284811:AGOS AFR330C
gene id: 284811:AGOS_AFR330C
uniprot id: Q753I2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

284811:AGOS ADL381W
gene id: 284811:AGOS_ADL381W
uniprot id: Q75BE5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG14 family.
messages: Coiled-Coils at the N-terminal half are essential for autophagy.
messages: Preautophagosomal structure membrane
messages: Required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. ATG14 mediates the specific binding of the VPS34 PI3-kinase complex I to the preautophagosomal structure (PAS) (By similarity).
messages: Vacuole membrane

284811:AGOS AEL133C
gene id: 284811:AGOS_AEL133C
uniprot id: Q757Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

284811:AGOS ABR201W
gene id: 284811:AGOS_ABR201W
uniprot id: Q75D21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CGI121/TPRKB family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification (By similarity).
messages: Nucleus
messages: telomere

284811:AGOS AER444W
gene id: 284811:AGOS_AER444W
uniprot id: Q755S4
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADR279C
gene id: 284811:AGOS_ADR279C
uniprot id: Q759J8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

284811:AGOS AER430W
gene id: 284811:AGOS_AER430W
uniprot id: Q755T8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a heterotrimeric complex containing IMP3, IMP4 and MPP10.
messages: Component of the U3 small nucleolar ribonucleoprotein. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing (By similarity).
messages: nucleolus

284811:AGOS AFR736C
gene id: 284811:AGOS_AFR736C
uniprot id: Q751T9
names: Similarity
messages: Belongs to the MT-A70-like family.

284811:AGOS AFR274C
gene id: 284811:AGOS_AFR274C
uniprot id: Q753N8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

284811:AGOS AGR379W
gene id: 284811:AGOS_AGR379W
uniprot id: Q74Z27
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

284811:AGOS AEL038C
gene id: 284811:AGOS_AEL038C
uniprot id: Q757Q0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

284811:AGOS ADR121W
gene id: 284811:AGOS_ADR121W
uniprot id: Q75A06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity).

284811:AGOS ADL028W
gene id: 284811:AGOS_ADL028W
uniprot id: Q75AE5
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AEL035W
gene id: 284811:AGOS_AEL035W
uniprot id: Q757P7
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

284811:AGOS AEL058W
gene id: 284811:AGOS_AEL058W
uniprot id: Q757S0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

284811:AGOS ACL155W
gene id: 284811:AGOS_ACL155W
uniprot id: Q75CS4
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.

284811:AGOS AFR674C
gene id: 284811:AGOS_AFR674C
uniprot id: Q752A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

284811:AGOS AER248W
gene id: 284811:AGOS_AER248W
uniprot id: Q756K6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.

284811:AGOS AER287W
gene id: 284811:AGOS_AER287W
uniprot id: Q756W8
names: Similarity
messages: Belongs to the sorting nexin family.

284811:AGOS ADR382W
gene id: 284811:AGOS_ADR382W
uniprot id: Q758Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS AAL002W
gene id: 284811:AGOS_AAL002W
uniprot id: Q75ET0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

284811:AGOS AFL178W
gene id: 284811:AGOS_AFL178W
uniprot id: Q755K1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG3 family.
messages: Cytoplasm
messages: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).
messages: Monomer. Interacts with ATG8 through an intermediate thioester bond through the C-terminal Gly of ATG8. Also interacts with the 40 amino acid C-terminal region of the E1-like ATG7 enzyme. Interacts also with the ATG12-ATG5 conjugate.
messages: The N-terminal region is involved in phosphatidylethanolamine-binding and is required for ATG8-PE conjugation.
messages: The flexible region (FR) is required for ATG7-binding.
messages: The handle region (HR) contains the ATG8 interaction motif (AIM) and mediates binding to ATG8. It is crucial for the cytoplasm-to-vacuole targeting pathway (By similarity).

284811:AGOS ADL157C
gene id: 284811:AGOS_ADL157C
uniprot id: Q75AS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

284811:AGOS AEL130C
gene id: 284811:AGOS_AEL130C
uniprot id: Q757Z0
names: Similarity
messages: Belongs to the PGA52 family.

284811:AGOS AGL003W
gene id: 284811:AGOS_AGL003W
uniprot id: Q750F7
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

284811:AGOS ADR188C
gene id: 284811:AGOS_ADR188C
uniprot id: Q759T5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

284811:AGOS AGR369W
gene id: 284811:AGOS_AGR369W
uniprot id: Q74Z37
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Putative transcription factor.

284811:AGOS ABR172W
gene id: 284811:AGOS_ABR172W
uniprot id: Q75D51
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

284811:AGOS ADL345C
gene id: 284811:AGOS_ADL345C
uniprot id: Q75BB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

284811:AGOS AGL127C
gene id: 284811:AGOS_AGL127C
uniprot id: Q751A7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cation homeostasis and in the regulation of the cation stress signaling cascades.
messages: Nucleus

284811:AGOS AFR007W
gene id: 284811:AGOS_AFR007W
uniprot id: Q754R5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Late endosome membrane
messages: RFU1 is an inhibitor of deubiquitination activity.
messages: Ubiquitin thioesterase that acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole. Removes also ubiquitin from soluble proteins targeted to proteasomes. Is essential to maintain a normal level of free ubiquitin. Required for promoting coordination of DNA replication and avoids DNA overreplication (By similarity).

284811:AGOS AER063W
gene id: 284811:AGOS_AER063W
uniprot id: Q757F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fungal cytochrome c oxidase subunit 7a family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

284811:AGOS ACR109W
gene id: 284811:AGOS_ACR109W
uniprot id: Q75CE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS AGL083W
gene id: 284811:AGOS_AGL083W
uniprot id: Q750N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDS1/RGT1 family.
messages: Cytoplasm
messages: Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose. In the absence of glucose, it functions as a transcriptional repressor, whereas high concentrations of glucose cause it to function as a transcriptional activator. In cells growing on low levels of glucose, has a neutral role, neither repressing nor activating transcription (By similarity).
messages: Nucleus

284811:AGOS AGL161C
gene id: 284811:AGOS_AGL161C
uniprot id: Q750V0
names: Similarity
messages: Belongs to the glycosyl hydrolase 81 family.

284811:AGOS AGR406C
gene id: 284811:AGOS_AGR406C
uniprot id: Q74Z01
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

284811:AGOS AEL260C
gene id: 284811:AGOS_AEL260C
uniprot id: Q758M1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS AER386W
gene id: 284811:AGOS_AER386W
uniprot id: Q755Y2
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

284811:AGOS AAL128C
gene id: 284811:AGOS_AAL128C
uniprot id: Q75F56
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

284811:AGOS AFR021W
gene id: 284811:AGOS_AFR021W
uniprot id: Q754Q1
names: Similarity
messages: Belongs to the APC1 family.

284811:AGOS ACR144W
gene id: 284811:AGOS_ACR144W
uniprot id: Q75BX7
names: Similarity
messages: Belongs to the peptidase A1 family.

284811:AGOS ADL343C
gene id: 284811:AGOS_ADL343C
uniprot id: Q75BB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The TREX-2 complex interacts with the nucleoporin NUP1. Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with THP1, SAC3, SGF11, and with the RNA polymerase II.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies (By similarity).
messages: P-body
messages: nucleoplasm

284811:AGOS AFR628C
gene id: 284811:AGOS_AFR628C
uniprot id: Q752E8
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ACR070W
gene id: 284811:AGOS_ACR070W
uniprot id: Q75C47
names: Similarity
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.

284811:AGOS AER390W
gene id: 284811:AGOS_AER390W
uniprot id: Q755X8
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.

284811:AGOS AGR193C
gene id: 284811:AGOS_AGR193C
uniprot id: Q74ZK7
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

284811:AGOS AFR703W
gene id: 284811:AGOS_AFR703W
uniprot id: Q751X2
names: Similarity
messages: In the C-terminal section; belongs to the histidinol dehydrogenase family.

284811:AGOS AAR069W
gene id: 284811:AGOS_AAR069W
uniprot id: Q75EL0
names: Similarity
messages: Belongs to the peptidase S8 family.

284811:AGOS ADR060C
gene id: 284811:AGOS_ADR060C
uniprot id: Q75A59
names: Function
names: Subcellular Location Annotation
messages: Involved in transcriptional activation. Also required for ubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. Its precise role in H2BK123ub1 formation however is unclear (By similarity).
messages: Nucleus

284811:AGOS AGL152C
gene id: 284811:AGOS_AGL152C
uniprot id: Q750U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STB3 family.
messages: Cytoplasm

284811:AGOS ADR389C
gene id: 284811:AGOS_ADR389C
uniprot id: Q758Y8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

284811:AGOS AGR279C
gene id: 284811:AGOS_AGR279C
uniprot id: Q74ZC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
messages: Nucleus

284811:AGOS AER396W
gene id: 284811:AGOS_AER396W
uniprot id: Q755X2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG8 family.
messages: The C-terminal 5 residues are removed by ATG4 to expose Gly-115 at the C-terminus. The C-terminal Gly is then amidated with phosphatidylethanolamine by an activating system similar to that for ubiquitin.
messages: Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
messages: Vacuole membrane
messages: autophagosome membrane

284811:AGOS AGL040C
gene id: 284811:AGOS_AGL040C
uniprot id: Q750J1
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.

284811:AGOS AGR374C
gene id: 284811:AGOS_AGR374C
uniprot id: Q74Z32
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPH3 family.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.
messages: Cytoplasm
messages: Nucleus
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
messages: The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function.

284811:AGOS AFL141C
gene id: 284811:AGOS_AFL141C
uniprot id: Q755G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1) (By similarity). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c'' (By similarity).
messages: Vacuole membrane

284811:AGOS ADL352C
gene id: 284811:AGOS_ADL352C
uniprot id: Q75BB9
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

284811:AGOS AFR693C
gene id: 284811:AGOS_AFR693C
uniprot id: Q751Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

284811:AGOS AEL276C
gene id: 284811:AGOS_AEL276C
uniprot id: Q758N1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

284811:AGOS AFR520W
gene id: 284811:AGOS_AFR520W
uniprot id: Q752Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enhancer of polycomb family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

284811:AGOS ADL058W
gene id: 284811:AGOS_ADL058W
uniprot id: Q75AI5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

284811:AGOS AFR285C
gene id: 284811:AGOS_AFR285C
uniprot id: Q753M7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Component of the 60S subunit of the ribosome.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus

284811:AGOS AGL183C
gene id: 284811:AGOS_AGL183C
uniprot id: Q750X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns (By similarity).
messages: Nucleus

284811:AGOS ADR191C
gene id: 284811:AGOS_ADR191C
uniprot id: Q759T2
names: Similarity
messages: Belongs to the proteasome subunit S11 family.

284811:AGOS AFL155C
gene id: 284811:AGOS_AFL155C
uniprot id: Q755H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Golgi apparatus membrane
messages: Probable serine protease.
messages: cis-Golgi network membrane

284811:AGOS ADR036C
gene id: 284811:AGOS_ADR036C
uniprot id: Q75A82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adenine nucleotide transporter involved in the uniport of ATP and adenine nucleotide hetero-exchange transport between the cytosol and the peroxisomal lumen. This transport is accompanied by a proton transport from the peroxisomal lumen to the cytosol. Transport of ATP into the peroxisome is required for beta-oxidation of medium-chain fatty acids (By similarity).
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Peroxisome membrane

284811:AGOS AGR355C
gene id: 284811:AGOS_AGR355C
uniprot id: Q74Z51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex DAD4 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
messages: Nucleus
messages: The DASH complex oligomerizes to form rings that encircle the microtubules.
messages: kinetochore
messages: spindle

284811:AGOS AFR098W
gene id: 284811:AGOS_AFR098W
uniprot id: Q754H4
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

284811:AGOS ACL165C
gene id: 284811:AGOS_ACL165C
uniprot id: P62583
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Homotetramer.
messages: Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting (By similarity).

284811:AGOS ADL076W
gene id: 284811:AGOS_ADL076W
uniprot id: Q75AK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

284811:AGOS AEL117C
gene id: 284811:AGOS_AEL117C
uniprot id: Q757X7
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ABR068C
gene id: 284811:AGOS_ABR068C
uniprot id: Q75DF8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

284811:AGOS AAL137W
gene id: 284811:AGOS_AAL137W
uniprot id: Q75F65
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THI4 family.
messages: Binds 1 Fe cation per subunit.
messages: Cytoplasm
messages: During the catalytic reaction, a sulfide is transferred from Cys-210 to a reaction intermediate, generating a dehydroalanine residue.
messages: Homooctamer.
messages: Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
messages: Nucleus

284811:AGOS AER345W
gene id: 284811:AGOS_AER345W
uniprot id: Q756C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA (By similarity).
messages: Belongs to the CAF20 family.
messages: Cytoplasm

284811:AGOS ADR071W
gene id: 284811:AGOS_ADR071W
uniprot id: Q75A48
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG9 family.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Forms a homotrimer with a solvated central pore, which is connected laterally to the cytosol through the cavity within each protomer. Acts as a lipid scramblase that uses its central pore to function: the central pore opens laterally to accommodate lipid headgroups, thereby enabling lipid flipping and redistribution of lipids added to the outer leaflet of ATG9-containing vesicles, thereby enabling growth into autophagosomes.
messages: Golgi apparatus membrane
messages: Homotrimer; forms a homotrimer with a central pore that forms a path between the two membrane leaflets.
messages: Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Required for mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking.
messages: Phosphorylated by ATG1. ATG1 phosphorylation is required for preautophagosome elongation.
messages: Preautophagosomal structure membrane

284811:AGOS ACR155W
gene id: 284811:AGOS_ACR155W
uniprot id: Q75BW6
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

284811:AGOS AER369C
gene id: 284811:AGOS_AER369C
uniprot id: Q755Z8
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AAL144C
gene id: 284811:AGOS_AAL144C
uniprot id: Q75F72
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

284811:AGOS AAR020W
gene id: 284811:AGOS_AAR020W
uniprot id: Q75EQ9
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AFR112W
gene id: 284811:AGOS_AFR112W
uniprot id: Q754F8
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AFR393W
gene id: 284811:AGOS_AFR393W
uniprot id: Q753C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHE9 family.
messages: Homooligomer.
messages: Mitochondrion inner membrane
messages: Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed (By similarity).

284811:AGOS AFR534W
gene id: 284811:AGOS_AFR534W
uniprot id: Q752N9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Cytoplasm

284811:AGOS ADR137W
gene id: 284811:AGOS_ADR137W
uniprot id: Q759Y6
names: Function
names: Subcellular Location Annotation
messages: Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
messages: Cytoplasm
messages: Nucleus

284811:AGOS AER233C
gene id: 284811:AGOS_AER233C
uniprot id: Q756M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein-DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G-quadruplex (G4) unwinding activity and can suppress G4-induced genome instability when PIF1 levels are low.
messages: Belongs to the helicase family. PIF1 subfamily.
messages: Nucleus
messages: telomere

284811:AGOS AER171W
gene id: 284811:AGOS_AER171W
uniprot id: Q756T2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with missfolded ER lumenal proteins.
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).

284811:AGOS AGR351W
gene id: 284811:AGOS_AGR351W
uniprot id: Q74Z55
names: Similarity
messages: Belongs to the terpene cyclase/mutase family.

284811:AGOS ABR075C
gene id: 284811:AGOS_ABR075C
uniprot id: Q75DF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTP family.
messages: Involved in protein synthesis. Involved in microtubule stabilization.
messages: cytoskeleton

284811:AGOS AEL157W
gene id: 284811:AGOS_AEL157W
uniprot id: Q758A9
names: Similarity
messages: Belongs to the PAF1 family.

284811:AGOS AFL114W
gene id: 284811:AGOS_AFL114W
uniprot id: Q755D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. SAR1 family.
messages: COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to SAR1-GDP triggers coat release and recycles COPII subunits (By similarity).

284811:AGOS AFR306C
gene id: 284811:AGOS_AFR306C
uniprot id: Q753K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

284811:AGOS AGR092W
gene id: 284811:AGOS_AGR092W
uniprot id: Q74ZV7
names: Similarity
messages: Belongs to the FGGY kinase family.

284811:AGOS ADR367C
gene id: 284811:AGOS_ADR367C
uniprot id: Q759B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mis12 family.
messages: kinetochore

284811:AGOS AAL012C
gene id: 284811:AGOS_AAL012C
uniprot id: O60027
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

284811:AGOS ABL078C
gene id: 284811:AGOS_ABL078C
uniprot id: Q75DV1
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

284811:AGOS AGR010C
gene id: 284811:AGOS_AGR010C
uniprot id: Q750E5
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AFR192W
gene id: 284811:AGOS_AFR192W
uniprot id: Q753Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OCA5 family.
messages: Cytoplasm

284811:AGOS AFR667C
gene id: 284811:AGOS_AFR667C
uniprot id: Q752A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

284811:AGOS AEL243W
gene id: 284811:AGOS_AEL243W
uniprot id: Q758K5
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

284811:AGOS AFR440C
gene id: 284811:AGOS_AFR440C
uniprot id: Q752Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Mitochondrion membrane

284811:AGOS ABL072C
gene id: 284811:AGOS_ABL072C
uniprot id: Q75DU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RIX1/PELP1 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.
messages: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.
messages: Nucleus

284811:AGOS AGL072W
gene id: 284811:AGOS_AGL072W
uniprot id: Q750M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP18 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking.

284811:AGOS AGR364C
gene id: 284811:AGOS_AGR364C
uniprot id: Q74Z42
names: Subcellular Location Annotation
messages: Cytoplasm

284811:AGOS ADL192W
gene id: 284811:AGOS_ADL192W
uniprot id: Q75AW2
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

284811:AGOS ABR124C
gene id: 284811:AGOS_ABR124C
uniprot id: Q75DA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

284811:AGOS AFL121W
gene id: 284811:AGOS_AFL121W
uniprot id: Q755E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
messages: Belongs to the peptidase S16 family.
messages: Peroxisome matrix

284811:AGOS AGR233W
gene id: 284811:AGOS_AGR233W
uniprot id: Q74ZH4
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

284811:AGOS AGR232C
gene id: 284811:AGOS_AGR232C
uniprot id: Q74ZH5
names: Similarity
messages: Belongs to the BolA/IbaG family.

284811:AGOS AEL318W
gene id: 284811:AGOS_AEL318W
uniprot id: Q758S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

284811:AGOS AER313C
gene id: 284811:AGOS_AER313C
uniprot id: Q756F2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endopolyphosphatase PPN1 family.
messages: Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.
messages: Processing by proteases in the vacuole may be required for activation.
messages: Vacuole membrane

284811:AGOS ADR208W
gene id: 284811:AGOS_ADR208W
uniprot id: Q759R5
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS AER005C
gene id: 284811:AGOS_AER005C
uniprot id: Q757K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).

284811:AGOS ACL162C
gene id: 284811:AGOS_ACL162C
uniprot id: Q75CT1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane

284811:AGOS AFR371W
gene id: 284811:AGOS_AFR371W
uniprot id: Q753E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

284811:AGOS AGL117C
gene id: 284811:AGOS_AGL117C
uniprot id: Q750Q9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Heterodimers with GPN1 or GPN2. Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

284811:AGOS AFL227C
gene id: 284811:AGOS_AFL227C
uniprot id: Q755P0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YAF9 family.
messages: Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: The coiled-coil domain is required for assembly into the NuA4 complex.

284811:AGOS ACL146C
gene id: 284811:AGOS_ACL146C
uniprot id: Q75CR5
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

284811:AGOS AGR072W
gene id: 284811:AGOS_AGR072W
uniprot id: Q74ZY6
names: Function
names: Similarity
messages: Belongs to the LCL2 family.
messages: Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.

284811:AGOS ACL200W
gene id: 284811:AGOS_ACL200W
uniprot id: Q75CW6
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

284811:AGOS AGL357W
gene id: 284811:AGOS_AGL357W
uniprot id: Q751P6
names: Similarity
messages: Belongs to the peptidase C19 family.

284811:AGOS AAR166C
gene id: 284811:AGOS_AAR166C
uniprot id: Q75EB1
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ABL165C
gene id: 284811:AGOS_ABL165C
uniprot id: Q75E35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RTT106 family.
messages: Chromosome
messages: Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity).
messages: Interacts with histones H3 and H4.
messages: Nucleus

284811:AGOS ADR395C
gene id: 284811:AGOS_ADR395C
uniprot id: Q758Y3
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

284811:AGOS AGL346W
gene id: 284811:AGOS_AGL346W
uniprot id: Q751N6
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ABR004C
gene id: 284811:AGOS_ABR004C
uniprot id: Q75DL4
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADL053C
gene id: 284811:AGOS_ADL053C
uniprot id: Q75AI0
names: Similarity
messages: Belongs to the protein kinase superfamily.

284811:AGOS ABL005C
gene id: 284811:AGOS_ABL005C
uniprot id: Q75DM2
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AEL303C
gene id: 284811:AGOS_AEL303C
uniprot id: Q758Q6
names: Function
names: Similarity
messages: Belongs to the SPG4 family.
messages: Stationary phase-essential protein not required for growth on nonfermentable carbon sources.

284811:AGOS ADR018C
gene id: 284811:AGOS_ADR018C
uniprot id: Q75AA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAN1 family.
messages: Cell membrane
messages: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
messages: Component of the PAN1 actin cytoskeleton-regulatory complex.
messages: Endosome membrane
messages: actin patch

284811:AGOS AGR082C
gene id: 284811:AGOS_AGR082C
uniprot id: Q74ZX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GEP5 family.
messages: Essential for respiratory growth and required for maintenance of mtDNA. Required for cell survival in the absence of prohibitins (By similarity).
messages: Mitochondrion

284811:AGOS ABR084W
gene id: 284811:AGOS_ABR084W
uniprot id: Q75DE3
names: Similarity
messages: Belongs to the actin family.

284811:AGOS AFL081W
gene id: 284811:AGOS_AFL081W
uniprot id: Q755A6
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR253W
gene id: 284811:AGOS_AFR253W
uniprot id: Q753S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

284811:AGOS ACL197W
gene id: 284811:AGOS_ACL197W
uniprot id: Q75CW3
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

284811:AGOS AER376W
gene id: 284811:AGOS_AER376W
uniprot id: Q755Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRT14 family.
messages: Involved in ribosome biogenesis, probably through modulation of rDNA transcription.
messages: nucleolus

284811:AGOS AAR059C
gene id: 284811:AGOS_AAR059C
uniprot id: Q00063
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

284811:AGOS AFR386C
gene id: 284811:AGOS_AFR386C
uniprot id: Q753D0
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

284811:AGOS AAR165W
gene id: 284811:AGOS_AAR165W
uniprot id: Q75EB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.
messages: Endoplasmic reticulum membrane
messages: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.
messages: Membrane

284811:AGOS ABL171W
gene id: 284811:AGOS_ABL171W
uniprot id: Q75E41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRE4 family.
messages: May be involved in intracellular vesicle transport.
messages: Membrane

284811:AGOS AFR662C
gene id: 284811:AGOS_AFR662C
uniprot id: Q752B3
names: Similarity
messages: Belongs to the UFD1 family.

284811:AGOS ADR168C
gene id: 284811:AGOS_ADR168C
uniprot id: Q759V4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
messages: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
messages: Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1) (By similarity).
messages: Nucleus

284811:AGOS ADR110C
gene id: 284811:AGOS_ADR110C
uniprot id: Q75A17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA.

284811:AGOS AGR153C
gene id: 284811:AGOS_AGR153C
uniprot id: Q74ZP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking.

284811:AGOS AFR478W
gene id: 284811:AGOS_AFR478W
uniprot id: Q752U5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

284811:AGOS AAR013W
gene id: 284811:AGOS_AAR013W
uniprot id: P62512
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIM1 family.
messages: Mitochondrion outer membrane
messages: Required for the assembly of the TOM (translocase of outer membrane) receptor complex, which is responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins.

284811:AGOS AEL119W
gene id: 284811:AGOS_AEL119W
uniprot id: Q757X9
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

284811:AGOS ADL348W
gene id: 284811:AGOS_ADL348W
uniprot id: Q75BB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane
messages: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly PDI1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on PDI1 to transfer oxidizing equivalent. Does not oxidize all pdi related proteins, suggesting that it can discriminate between PDI1 and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress (By similarity).
messages: May function both as a monomer and a homodimer.

284811:AGOS AFR033C
gene id: 284811:AGOS_AFR033C
uniprot id: Q754N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHS7 family.
messages: Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum.
messages: Endoplasmic reticulum membrane
messages: Interacts with CHS3.

284811:AGOS ADL114C
gene id: 284811:AGOS_ADL114C
uniprot id: Q75AN6
names: Similarity
messages: Belongs to the TPA1 family.

284811:AGOS ACR219W
gene id: 284811:AGOS_ACR219W
uniprot id: Q75BQ2
names: Similarity
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Tetramer of two alpha and two beta subunits.

284811:AGOS AGL133W
gene id: 284811:AGOS_AGL133W
uniprot id: Q750S2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus
messages: Plays a structural role in chromatin. Probably involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity).

284811:AGOS AEL336W
gene id: 284811:AGOS_AEL336W
uniprot id: Q758T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWC3 family.
messages: Component of the SWR1 chromatin remodeling complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
messages: Nucleus

284811:AGOS AGL074W
gene id: 284811:AGOS_AGL074W
uniprot id: Q750N0
names: Similarity
messages: Belongs to the PDCD5 family.

284811:AGOS ACL117W
gene id: 284811:AGOS_ACL117W
uniprot id: Q75CN6
names: Similarity
messages: Belongs to the IlvD/Edd family.

284811:AGOS AEL321C
gene id: 284811:AGOS_AEL321C
uniprot id: Q758S3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S) (By similarity).
messages: Mitochondrion

284811:AGOS AFR023W
gene id: 284811:AGOS_AFR023W
uniprot id: Q754P9
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

284811:AGOS ADL264C
gene id: 284811:AGOS_ADL264C
uniprot id: Q75B41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

284811:AGOS ADR334W
gene id: 284811:AGOS_ADR334W
uniprot id: Q759E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

284811:AGOS AGR040C
gene id: 284811:AGOS_AGR040C
uniprot id: Q750B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

284811:AGOS AAR191C
gene id: 284811:AGOS_AAR191C
uniprot id: Q75E89
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

284811:AGOS AFR353W
gene id: 284811:AGOS_AFR353W
uniprot id: Q753G1
names: Similarity
messages: Belongs to the Cdt1 family.

284811:AGOS ADR331C
gene id: 284811:AGOS_ADR331C
uniprot id: Q759E6
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

284811:AGOS AEL202C
gene id: 284811:AGOS_AEL202C
uniprot id: Q758G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the palH/RIM21 family.
messages: Cell membrane
messages: Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.

284811:AGOS ABR226W
gene id: 284811:AGOS_ABR226W
uniprot id: Q75CZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FYV7 family.
messages: Involved in the processing of the 20S pre-rRNA.
messages: nucleolus

284811:AGOS AFR189C
gene id: 284811:AGOS_AFR189C
uniprot id: Q753Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
messages: Polynucleotide 5'-kinase involved in rRNA processing.
messages: nucleolus

284811:AGOS ADL232W
gene id: 284811:AGOS_ADL232W
uniprot id: Q75B09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

284811:AGOS AER330W
gene id: 284811:AGOS_AER330W
uniprot id: Q756D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS ADL211C
gene id: 284811:AGOS_ADL211C
uniprot id: Q75AY1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Component of the mitochondrial small ribosomal subunit.
messages: Mitochondrion

284811:AGOS AGL125C
gene id: 284811:AGOS_AGL125C
uniprot id: Q750R7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts with ERF4.
messages: The DHHC domain is required for palmitoyltransferase activity.
messages: The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins.

284811:AGOS ADR106W
gene id: 284811:AGOS_ADR106W
uniprot id: Q75AG7
names: Similarity
messages: Belongs to the cullin family.

284811:AGOS AGR276W
gene id: 284811:AGOS_AGR276W
uniprot id: Q74ZC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

284811:AGOS AFL145W
gene id: 284811:AGOS_AFL145W
uniprot id: Q755G8
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

284811:AGOS ADL125C
gene id: 284811:AGOS_ADL125C
uniprot id: Q75AP5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

284811:AGOS AAL100C
gene id: 284811:AGOS_AAL100C
uniprot id: Q75F28
names: Similarity
messages: Belongs to the TMA16 family.

284811:AGOS AEL191C
gene id: 284811:AGOS_AEL191C
uniprot id: Q758F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCO1/2 family.
messages: Mitochondrion inner membrane

284811:AGOS AEL344W
gene id: 284811:AGOS_AEL344W
uniprot id: Q758U6
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ACR229W
gene id: 284811:AGOS_ACR229W
uniprot id: Q75BP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

284811:AGOS ADR113W
gene id: 284811:AGOS_ADR113W
uniprot id: Q75A11
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

284811:AGOS ACR286C
gene id: 284811:AGOS_ACR286C
uniprot id: Q75BI5
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AER100C
gene id: 284811:AGOS_AER100C
uniprot id: Q757B3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

284811:AGOS ACR258W
gene id: 284811:AGOS_ACR258W
uniprot id: Q9C1M7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynein heavy chain family.
messages: Consists of at least two heavy chains and a number of intermediate and light chains.
messages: Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.
messages: Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
messages: cytoskeleton

284811:AGOS AAL150W
gene id: 284811:AGOS_AAL150W
uniprot id: Q75F78
names: Similarity
messages: Belongs to the HGH1 family.

284811:AGOS ACR187W
gene id: 284811:AGOS_ACR187W
uniprot id: Q75BT4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

284811:AGOS AER169C
gene id: 284811:AGOS_AER169C
uniprot id: Q756T4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

284811:AGOS AER299C
gene id: 284811:AGOS_AER299C
uniprot id: Q756G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

284811:AGOS AFR166C
gene id: 284811:AGOS_AFR166C
uniprot id: Q754A6
names: Similarity
messages: Belongs to the PPP phosphatase family.

284811:AGOS AGL242C
gene id: 284811:AGOS_AGL242C
uniprot id: Q751E8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Interacts with a number of cyclins.
messages: When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.

284811:AGOS ADL325C
gene id: 284811:AGOS_ADL325C
uniprot id: Q75B95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRR1 family.
messages: Involved in mRNA splicing. Required for snRNA accumulation and manufacture of snRNPs (By similarity).
messages: Nucleus

284811:AGOS ABL116C
gene id: 284811:AGOS_ABL116C
uniprot id: Q75DY9
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADL072C
gene id: 284811:AGOS_ADL072C
uniprot id: Q75AJ9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

284811:AGOS ACL150W
gene id: 284811:AGOS_ACL150W
uniprot id: Q75CR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation.
messages: Cytoplasm
messages: Nucleus

284811:AGOS ADR087C
gene id: 284811:AGOS_ADR087C
uniprot id: Q75A33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

284811:AGOS ABL026W
gene id: 284811:AGOS_ABL026W
uniprot id: Q75DP3
names: Similarity
messages: Belongs to the SSH4 family.

284811:AGOS AAL104C
gene id: 284811:AGOS_AAL104C
uniprot id: Q75F32
names: Similarity
messages: Belongs to the NXF family.

284811:AGOS AFR173W
gene id: 284811:AGOS_AFR173W
uniprot id: Q753Z9
names: Similarity
messages: Belongs to the MT-A70-like family.

284811:AGOS AGR079W
gene id: 284811:AGOS_AGR079W
uniprot id: Q74ZX9
names: Similarity
messages: Belongs to the eIF2D family.

284811:AGOS ADR184W
gene id: 284811:AGOS_ADR184W
uniprot id: Q759T9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family. PreP subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running (By similarity). Preferentially cleaves the N-terminal side of paired basic amino acid residues (By similarity). Also degrades other unstructured peptides (By similarity). May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase (By similarity).
messages: Mitochondrion intermembrane space
messages: Mitochondrion matrix
messages: Monomer and homodimer; homodimerization is induced by binding of the substrate.

284811:AGOS AFL102W
gene id: 284811:AGOS_AFL102W
uniprot id: Q755C5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA (By similarity).
messages: Belongs to the DEAD box helicase family. MRH4 subfamily.
messages: Mitochondrion
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

284811:AGOS AFR668W
gene id: 284811:AGOS_AFR668W
uniprot id: Q752A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

284811:AGOS ADR075W
gene id: 284811:AGOS_ADR075W
uniprot id: Q75A44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDB17 family.
messages: Cytoplasm
messages: May be involved in protein-linked oligosaccharide phosphorylation.

284811:AGOS AFL188C
gene id: 284811:AGOS_AFL188C
uniprot id: Q755K5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.

284811:AGOS AFL089C
gene id: 284811:AGOS_AFL089C
uniprot id: Q755B4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

284811:AGOS ACR129W
gene id: 284811:AGOS_ACR129W
uniprot id: Q75BZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Mitochondrion
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of mitochondrial acyl-carrier-protein.

284811:AGOS AFR179C
gene id: 284811:AGOS_AFR179C
uniprot id: Q753Z3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

284811:AGOS ABL136C
gene id: 284811:AGOS_ABL136C
uniprot id: Q75E09
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

284811:AGOS AFL091W
gene id: 284811:AGOS_AFL091W
uniprot id: Q755B6
names: Similarity
messages: Belongs to the protein kinase superfamily.

284811:AGOS ABR053C
gene id: 284811:AGOS_ABR053C
uniprot id: Q75DH3
names: Similarity
messages: Belongs to the cytochrome P450 family.

284811:AGOS AAR099W
gene id: 284811:AGOS_AAR099W
uniprot id: Q75EI0
names: Similarity
messages: Belongs to the cyclin family.

284811:AGOS ADL266C
gene id: 284811:AGOS_ADL266C
uniprot id: Q75B43
names: Function
names: Similarity
messages: Belongs to the peptidase C14B family.
messages: Involved in cell death (apoptosis).

284811:AGOS AFL035C
gene id: 284811:AGOS_AFL035C
uniprot id: Q754V6
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

284811:AGOS AAR108C
gene id: 284811:AGOS_AAR108C
uniprot id: Q75EH1
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

284811:AGOS ADL139W
gene id: 284811:AGOS_ADL139W
uniprot id: Q75AQ9
names: Similarity
messages: Belongs to the KNR4/SMI1 family.

284811:AGOS AFR394W
gene id: 284811:AGOS_AFR394W
uniprot id: Q753C2
names: Similarity
messages: Belongs to the AAA ATPase family.

284811:AGOS ACL066C
gene id: 284811:AGOS_ACL066C
uniprot id: Q75CI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG10 family.
messages: E2-like enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy and nucleophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for proper localization of ATG8 to the preautophagosomal structure (PAS). Likely serves as an ATG5-recognition molecule (By similarity).
messages: Forms homooligomers.
messages: Preautophagosomal structure membrane

284811:AGOS AFL174C
gene id: 284811:AGOS_AFL174C
uniprot id: Q755J7
names: Function
names: Similarity
messages: Belongs to the cyclin family.
messages: G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition.

284811:AGOS AGL201C
gene id: 284811:AGOS_AGL201C
uniprot id: Q750Y8
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Homodimer.

284811:AGOS AFR719W
gene id: 284811:AGOS_AFR719W
uniprot id: Q751V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MGR1 family.
messages: Component of the mitochondrial inner membrane i-AAA protease complex required for mitochondrial inner membrane protein turnover.
messages: Component of the mitochondrial inner membrane i-AAA protease complex.
messages: Mitochondrion inner membrane

284811:AGOS AER112C
gene id: 284811:AGOS_AER112C
uniprot id: Q757A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AAL084W
gene id: 284811:AGOS_AAL084W
uniprot id: Q75F12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

284811:AGOS AFR228W
gene id: 284811:AGOS_AFR228W
uniprot id: Q753U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

284811:AGOS ACR198W
gene id: 284811:AGOS_ACR198W
uniprot id: Q75BS3
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

284811:AGOS AGR170C
gene id: 284811:AGOS_AGR170C
uniprot id: Q74ZM8
names: Similarity
messages: Belongs to the SLA1 family.

284811:AGOS ACR228C
gene id: 284811:AGOS_ACR228C
uniprot id: Q8J1G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.
messages: Required for assembly of the mitotic spindle. Interacts with spindle microtubules to produce an outwardly directed force acting upon the poles. Following spindle assembly, CIN8 and KIP1 apparently act to oppose a force that draws separated poles back together. This force seems to be mediate by KAR3 (By similarity).
messages: spindle

284811:AGOS ADR162W
gene id: 284811:AGOS_ADR162W
uniprot id: Q759W0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity).
messages: Membrane

284811:AGOS ABR022C
gene id: 284811:AGOS_ABR022C
uniprot id: Q75DS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm

284811:AGOS ACR217C
gene id: 284811:AGOS_ACR217C
uniprot id: Q75BQ4
names: Similarity
messages: Belongs to the oligoribonuclease family.

284811:AGOS AAR126W
gene id: 284811:AGOS_AAR126W
uniprot id: Q75EF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP17 family.
messages: nucleolus

284811:AGOS AFR658W
gene id: 284811:AGOS_AFR658W
uniprot id: Q752B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

284811:AGOS ADL088W
gene id: 284811:AGOS_ADL088W
uniprot id: Q75AL5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM1 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.
messages: Nucleus
messages: The JmjC domain mediates the demethylation activity.

284811:AGOS ADR299W
gene id: 284811:AGOS_ADR299W
uniprot id: Q759H9
names: Function
names: Similarity
messages: Belongs to the peptidase C13 family.
messages: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.

284811:AGOS AGL349C
gene id: 284811:AGOS_AGL349C
uniprot id: Q751N9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

284811:AGOS ACL044W
gene id: 284811:AGOS_ACL044W
uniprot id: Q75CG3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

284811:AGOS AEL249C
gene id: 284811:AGOS_AEL249C
uniprot id: Q758L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPI family.
messages: Homodimer.
messages: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.
messages: cytosol

284811:AGOS ACL202W
gene id: 284811:AGOS_ACL202W
uniprot id: Q75CW8
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

284811:AGOS ADR109W
gene id: 284811:AGOS_ADR109W
uniprot id: Q75A18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase inhibitor family.
messages: Forms a one-to-one complex with ATPase to inhibit the enzyme activity completely.
messages: Mitochondrion

284811:AGOS AGL334W
gene id: 284811:AGOS_AGL334W
uniprot id: Q751N1
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

284811:AGOS AFR151C
gene id: 284811:AGOS_AFR151C
uniprot id: Q754B9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis.
messages: Endoplasmic reticulum membrane
messages: The histidine box domains may contain the active site and/or be involved in metal ion binding.

284811:AGOS AFR635C
gene id: 284811:AGOS_AFR635C
uniprot id: Q752E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

284811:AGOS ACR126W
gene id: 284811:AGOS_ACR126W
uniprot id: Q75BZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP53 family.
messages: May play a role in ribosome biogenesis.
messages: nucleolus
messages: nucleoplasm

284811:AGOS AFL205C
gene id: 284811:AGOS_AFL205C
uniprot id: Q755L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

284811:AGOS ADR257C
gene id: 284811:AGOS_ADR257C
uniprot id: Q759L9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

284811:AGOS AFR686C
gene id: 284811:AGOS_AFR686C
uniprot id: Q751Y9
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

284811:AGOS AGR159C
gene id: 284811:AGOS_AGR159C
uniprot id: Q74ZN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

284811:AGOS ABR192CA
gene id: 284811:AGOS_ABR192CA
uniprot id: Q75D30
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Interacts with GPI2, suggesting that it is a component of the GPI-GnT complex, probably composed of GPI1, GPI2, GPI3, GPI15, and ERI1.
messages: Probable component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins.

284811:AGOS AFR377C
gene id: 284811:AGOS_AFR377C
uniprot id: Q753D9
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Serine/threonine-protein kinase.

284811:AGOS AGL067W
gene id: 284811:AGOS_AGL067W
uniprot id: Q750M4
names: Function
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

284811:AGOS ABR105C
gene id: 284811:AGOS_ABR105C
uniprot id: Q75DC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

284811:AGOS AFR553C
gene id: 284811:AGOS_AFR553C
uniprot id: Q752M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

284811:AGOS AGL098W
gene id: 284811:AGOS_AGL098W
uniprot id: Q750P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Cytoplasm
messages: Homodimer.

284811:AGOS ADL212W
gene id: 284811:AGOS_ADL212W
uniprot id: Q75AY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

284811:AGOS AER413C
gene id: 284811:AGOS_AER413C
uniprot id: Q755V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AFR566C
gene id: 284811:AGOS_AFR566C
uniprot id: Q752K8
names: Subcellular Location Annotation
messages: nucleolus

284811:AGOS AAL031W
gene id: 284811:AGOS_AAL031W
uniprot id: Q75EV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FYV6 family.
messages: Involved in telomere length regulation and promotes fully efficient non-homologous end-joining (NHEJ) by a mechanism activated in postdiauxic/stationary phase.
messages: Nucleus
messages: telomere

284811:AGOS ACR054C
gene id: 284811:AGOS_ACR054C
uniprot id: Q75C62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: May mediate the reduction of outer membrane cytochrome b5.
messages: Mitochondrion outer membrane

284811:AGOS ADR187W
gene id: 284811:AGOS_ADR187W
uniprot id: Q759T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT5 family.
messages: Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II (By similarity).
messages: Nucleus
messages: The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).

284811:AGOS AAR138C
gene id: 284811:AGOS_AAR138C
uniprot id: Q75EE3
names: Similarity
messages: Belongs to the SGT1 family.

284811:AGOS AFL043C
gene id: 284811:AGOS_AFL043C
uniprot id: Q754W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS ADR022W
gene id: 284811:AGOS_ADR022W
uniprot id: Q75A96
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ACL092C
gene id: 284811:AGOS_ACL092C
uniprot id: Q75CL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: actin patch

284811:AGOS ADL278C
gene id: 284811:AGOS_ADL278C
uniprot id: Q75B55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. GEP3 subfamily.
messages: May be involved in the mitochondrial lipid metabolism.
messages: Mitochondrion

284811:AGOS AFR229C
gene id: 284811:AGOS_AFR229C
uniprot id: Q753U6
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ACR034W
gene id: 284811:AGOS_ACR034W
uniprot id: Q75C82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity (By similarity).

284811:AGOS ADL206W
gene id: 284811:AGOS_ADL206W
uniprot id: Q75AX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Membrane

284811:AGOS AGL336W
gene id: 284811:AGOS_AGL336W
uniprot id: Q751N3
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

284811:AGOS AER157C
gene id: 284811:AGOS_AER157C
uniprot id: Q756U5
names: Similarity
messages: Belongs to the peptidase M28 family. M28B subfamily.

284811:AGOS AEL190W
gene id: 284811:AGOS_AEL190W
uniprot id: Q758F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chitin synthase family.
messages: Cell membrane
messages: Membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

284811:AGOS AEL196W
gene id: 284811:AGOS_AEL196W
uniprot id: Q758F8
names: Similarity
messages: Belongs to the activator 1 small subunits family.

284811:AGOS ABR059W
gene id: 284811:AGOS_ABR059W
uniprot id: Q75DG7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

284811:AGOS AAL007C
gene id: 284811:AGOS_AAL007C
uniprot id: Q75EU2
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

284811:AGOS AGR099C
gene id: 284811:AGOS_AGR099C
uniprot id: Q74ZU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

284811:AGOS AAL173C
gene id: 284811:AGOS_AAL173C
uniprot id: Q75F89
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AER097C
gene id: 284811:AGOS_AER097C
uniprot id: Q757B6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster facilitates the reduction of the catalytic iron-sulfur cluster in the DPH1 subunit.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.
messages: Cytoplasm
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1 (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity).

284811:AGOS AFR613C
gene id: 284811:AGOS_AFR613C
uniprot id: Q752G3
names: Similarity
messages: Belongs to the SecY/SEC61-alpha family.

284811:AGOS ADL129W
gene id: 284811:AGOS_ADL129W
uniprot id: Q75AP9
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

284811:AGOS AGR107C
gene id: 284811:AGOS_AGR107C
uniprot id: Q74ZU1
names: Similarity
messages: Belongs to the 14-3-3 family.

284811:AGOS AFR244C
gene id: 284811:AGOS_AFR244C
uniprot id: Q753T2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHE10 family.
messages: Component of the mitochondria-localized RNase mitochondrial RNA-processing (RNase MRP) composed of one single RNA encoded by the NME1 gene and at least 31 proteins. Absent in the nucleus-localized RNase MRP (NuMRP).
messages: Involved in spore wall assembly. May be a component of the mitochondrial RNase MRP (MtMRP), a ribonucleoprotein endoribonuclease involved in the cleaving RNA transcripts to generate primers for DNA replication in mitochondria.
messages: Mitochondrion

284811:AGOS ADL086C
gene id: 284811:AGOS_ADL086C
uniprot id: Q75AL3
names: Similarity
messages: Belongs to the aspartokinase family.

284811:AGOS AAL121C
gene id: 284811:AGOS_AAL121C
uniprot id: Q75F49
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.

284811:AGOS ACR026W
gene id: 284811:AGOS_ACR026W
uniprot id: Q75C90
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.

284811:AGOS ADL351W
gene id: 284811:AGOS_ADL351W
uniprot id: Q75BB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

284811:AGOS AER347W
gene id: 284811:AGOS_AER347W
uniprot id: Q756C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

284811:AGOS AFR417W
gene id: 284811:AGOS_AFR417W
uniprot id: Q753A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

284811:AGOS AFR711C
gene id: 284811:AGOS_AFR711C
uniprot id: Q751W4
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR708W
gene id: 284811:AGOS_AFR708W
uniprot id: Q751W7
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.

284811:AGOS ADL309W
gene id: 284811:AGOS_ADL309W
uniprot id: Q75B81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

284811:AGOS ADR390C
gene id: 284811:AGOS_ADR390C
uniprot id: Q758Y7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Prevacuolar compartment membrane
messages: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

284811:AGOS AFR351C
gene id: 284811:AGOS_AFR351C
uniprot id: Q753R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

284811:AGOS AGR387C
gene id: 284811:AGOS_AGR387C
uniprot id: Q74Z19
names: Similarity
messages: Belongs to the frataxin family.

284811:AGOS AFR231W
gene id: 284811:AGOS_AFR231W
uniprot id: Q753U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC family.
messages: Cytoplasm
messages: mRNA-binding protein which stimulates mRNA decapping.

284811:AGOS AER093C
gene id: 284811:AGOS_AER093C
uniprot id: Q757C0
names: Similarity
messages: Belongs to the Mo25 family.

284811:AGOS ADR350W
gene id: 284811:AGOS_ADR350W
uniprot id: Q759C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

284811:AGOS AER242C
gene id: 284811:AGOS_AER242C
uniprot id: Q756L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BLOC1S4 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1).
messages: Cytoplasm

284811:AGOS AGR289C
gene id: 284811:AGOS_AGR289C
uniprot id: Q74ZB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MEC3 family.
messages: Component of the checkpoint clamp complex composed of DDC1, MEC3 and RAD17.
messages: Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.
messages: Nucleus

284811:AGOS AFR322C
gene id: 284811:AGOS_AFR322C
uniprot id: Q753J0
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ACL168C
gene id: 284811:AGOS_ACL168C
uniprot id: Q75CT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
messages: Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

284811:AGOS ADR054C
gene id: 284811:AGOS_ADR054C
uniprot id: Q75A64
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EXO5 family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Mitochondrion
messages: Monomer.
messages: Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively (By similarity).

284811:AGOS ADL041C
gene id: 284811:AGOS_ADL041C
uniprot id: Q75AF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX19 family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Required for the assembly of mitochondrial cytochrome c oxidase.

284811:AGOS AFL176C
gene id: 284811:AGOS_AFL176C
uniprot id: Q755J9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS27 family.
messages: Both IUM domains are necessary for efficient binding to ubiquitin.
messages: Component of the ESCRT-0 complex composed of HSE1 and VPS27.
messages: Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
messages: Endosome membrane
messages: The FYVE domain is involved in the binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) which is required for the association to endosomal membranes.

284811:AGOS AAR035C
gene id: 284811:AGOS_AAR035C
uniprot id: Q75EP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

284811:AGOS AGL190W
gene id: 284811:AGOS_AGL190W
uniprot id: Q750X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Cytoplasm

284811:AGOS AGR199W
gene id: 284811:AGOS_AGR199W
uniprot id: Q74ZK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Membrane

284811:AGOS AFR513C
gene id: 284811:AGOS_AFR513C
uniprot id: Q752R0
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AAL127W
gene id: 284811:AGOS_AAL127W
uniprot id: Q75F55
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

284811:AGOS AAL145W
gene id: 284811:AGOS_AAL145W
uniprot id: Q75F73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS ADR296C
gene id: 284811:AGOS_ADR296C
uniprot id: Q759H4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-3 family.
messages: Involved in peroxisome biosynthesis.
messages: Peroxisome membrane

284811:AGOS AGR317C
gene id: 284811:AGOS_AGR317C
uniprot id: Q74Z86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

284811:AGOS ADR010C
gene id: 284811:AGOS_ADR010C
uniprot id: Q75AA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with ribosomal complexes.
messages: Belongs to the TMA20 family.
messages: Cytoplasm
messages: Involved in translation.

284811:AGOS AFR220W
gene id: 284811:AGOS_AFR220W
uniprot id: Q753V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Cytoplasm
messages: Nucleus
messages: Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity).

284811:AGOS AGL172W
gene id: 284811:AGOS_AGL172W
uniprot id: Q750W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal Na(+)/H(+) exchanger family.
messages: Membrane

284811:AGOS AER191W
gene id: 284811:AGOS_AER191W
uniprot id: Q756R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

284811:AGOS ABR092C
gene id: 284811:AGOS_ABR092C
uniprot id: Q75DD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

284811:AGOS AGL264W
gene id: 284811:AGOS_AGL264W
uniprot id: Q751H0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

284811:AGOS AER027W
gene id: 284811:AGOS_AER027W
uniprot id: Q757I6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

284811:AGOS AER339C
gene id: 284811:AGOS_AER339C
uniprot id: Q756C8
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ABL056C
gene id: 284811:AGOS_ABL056C
uniprot id: Q75DT2
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.
messages: Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).

284811:AGOS AER416C
gene id: 284811:AGOS_AER416C
uniprot id: Q755V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the END3 family.
messages: Cell membrane
messages: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
messages: Component of the PAN1 actin cytoskeleton-regulatory complex.
messages: Endosome membrane
messages: actin patch

284811:AGOS AFR190C
gene id: 284811:AGOS_AFR190C
uniprot id: Q753Y2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by C-terminal proteolytic cleavage by signaling protease (probably RIM13) at neutral to alkaline ambient pH.
messages: Belongs to the pacC/RIM101 family.
messages: Binds to DNA. Interacts with RIM20, which binds to the two YPX[LI] motifs and is required for proteolytic processing (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including palB/RIM101 itself) and represses transcription of acid-expressed genes (By similarity).

284811:AGOS AEL081W
gene id: 284811:AGOS_AEL081W
uniprot id: Q757U3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
messages: Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Required for respiration and the maintenance of the mitochondrial compartment.
messages: Homodimer.
messages: Mitochondrion matrix

284811:AGOS AER312W
gene id: 284811:AGOS_AER312W
uniprot id: Q756F9
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

284811:AGOS AAL119W
gene id: 284811:AGOS_AAL119W
uniprot id: Q75F47
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PROPPIN family.
messages: Component of the PI(3,5)P2 regulatory complex.
messages: Endosome membrane
messages: Preautophagosomal structure membrane
messages: The L/FRRG motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions.
messages: The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.
messages: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).
messages: Vacuole membrane

284811:AGOS AGL202W
gene id: 284811:AGOS_AGL202W
uniprot id: Q750Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ALG14 family.
messages: Endoplasmic reticulum membrane
messages: Heterodimer with ALG13 to form a functional enzyme.
messages: Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER (By similarity).
messages: Nucleus membrane

284811:AGOS ADR166W
gene id: 284811:AGOS_ADR166W
uniprot id: Q759V6
names: Similarity
messages: Belongs to the TRM112 family.

284811:AGOS ADR240C
gene id: 284811:AGOS_ADR240C
uniprot id: Q759N5
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

284811:AGOS AFR175C
gene id: 284811:AGOS_AFR175C
uniprot id: Q753Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.

284811:AGOS AER289W
gene id: 284811:AGOS_AER289W
uniprot id: Q756H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.
messages: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. It must be involved intimately in the translocation of a wide variety of protein substrates (By similarity).

284811:AGOS AFR477C
gene id: 284811:AGOS_AFR477C
uniprot id: Q752U6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

284811:AGOS AGR254C
gene id: 284811:AGOS_AGR254C
uniprot id: Q74ZE5
names: Similarity
messages: Belongs to the taffazin family.

284811:AGOS AFR388W
gene id: 284811:AGOS_AFR388W
uniprot id: Q753C8
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AFR002C
gene id: 284811:AGOS_AFR002C
uniprot id: Q754S0
names: Similarity
messages: Belongs to the VPS8 family.

284811:AGOS ADL268C
gene id: 284811:AGOS_ADL268C
uniprot id: Q75B45
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.

284811:AGOS AAR149W
gene id: 284811:AGOS_AAR149W
uniprot id: Q75EC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

284811:AGOS AER201C
gene id: 284811:AGOS_AER201C
uniprot id: Q756Q3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NPC2 family.
messages: Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
messages: Monomer.

284811:AGOS AGR322W
gene id: 284811:AGOS_AGR322W
uniprot id: Q74ZF6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfate adenylyltransferase family.
messages: Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.
messages: Cytoplasm
messages: Homohexamer. Dimer of trimers.
messages: The oligomerization domain is distantly related to APS kinases, but it is not functional and does not bind APS. It is required for oligomerization of the enzyme, although the oligomerization state has no effect on the catalytic activity of the enzyme.

284811:AGOS AER009C
gene id: 284811:AGOS_AER009C
uniprot id: Q757K3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA (By similarity).
messages: Nucleus

284811:AGOS ACR234C
gene id: 284811:AGOS_ACR234C
uniprot id: Q75BN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

284811:AGOS AFL101C
gene id: 284811:AGOS_AFL101C
uniprot id: Q755C4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: Nucleus
messages: Required for high-fidelity chromosome segregation during the later part of each cell cycle. Acts in opposition to the phosphatase PP1. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension. Phosphorylates histone H3 to form H3S10ph during mitosis and meiosis (By similarity).
messages: kinetochore
messages: spindle

284811:AGOS AAR132C
gene id: 284811:AGOS_AAR132C
uniprot id: Q75EE9
names: Similarity
messages: Belongs to the AFG1 ATPase family.

284811:AGOS AFR010C
gene id: 284811:AGOS_AFR010C
uniprot id: Q754R2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDI1 family.
messages: Binds ubiquitin and polyubiquitinated proteins.
messages: Cytoplasm
messages: Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.

284811:AGOS ACL116W
gene id: 284811:AGOS_ACL116W
uniprot id: Q75CN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

284811:AGOS ABR046C
gene id: 284811:AGOS_ABR046C
uniprot id: Q75DH9
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

284811:AGOS ACR184C
gene id: 284811:AGOS_ACR184C
uniprot id: Q75BT7
names: Similarity
messages: Belongs to the actin family.

284811:AGOS AMI007W
gene id: 284811:AGOS_AMI007W
uniprot id: Q75G38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 18 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i, j and k.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

284811:AGOS ABR034W
gene id: 284811:AGOS_ABR034W
uniprot id: Q75DJ0
names: Subcellular Location Annotation
messages: nuclear pore complex

284811:AGOS ACR140C
gene id: 284811:AGOS_ACR140C
uniprot id: Q75BY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Catalyzes the terminal and only committed step in triacylglycerol (TAG) synthesis by using diacylglycerol (DAG) and fatty acyl-CoA as substrates. Required for storage lipid synthesis. Major DAG esterifying enzyme in stationary phase when TAG production is particularly active. Involved in lipid particle synthesis from the endoplasmic reticulum, promoting localized TAG production at discrete ER subdomains.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet

284811:AGOS ACR202W
gene id: 284811:AGOS_ACR202W
uniprot id: Q75BR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion

284811:AGOS AER319W
gene id: 284811:AGOS_AER319W
uniprot id: Q756E6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

284811:AGOS AGL113C
gene id: 284811:AGOS_AGL113C
uniprot id: Q750Q5
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

284811:AGOS AAL093C
gene id: 284811:AGOS_AAL093C
uniprot id: Q75F21
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

284811:AGOS ADL305C
gene id: 284811:AGOS_ADL305C
uniprot id: Q75B77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

284811:AGOS ABR186W
gene id: 284811:AGOS_ABR186W
uniprot id: Q75D37
names: Function
names: Similarity
messages: Belongs to the PanB family.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

284811:AGOS AER322C
gene id: 284811:AGOS_AER322C
uniprot id: Q756E3
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

284811:AGOS ABR222W
gene id: 284811:AGOS_ABR222W
uniprot id: Q75D00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: cytoskeleton

284811:AGOS AGL171W
gene id: 284811:AGOS_AGL171W
uniprot id: Q750W0
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ACL126W
gene id: 284811:AGOS_ACL126W
uniprot id: Q75CP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
messages: Cytoplasm

284811:AGOS ACR115W
gene id: 284811:AGOS_ACR115W
uniprot id: Q75C04
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AER310W
gene id: 284811:AGOS_AER310W
uniprot id: Q756G1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the respiratory chain complex III/complex IV supercomplex.
messages: Belongs to the RCF1 family.
messages: Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.
messages: Mitochondrion membrane

284811:AGOS AFR201C
gene id: 284811:AGOS_AFR201C
uniprot id: Q753X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion inner membrane
messages: Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.

284811:AGOS AER172C
gene id: 284811:AGOS_AER172C
uniprot id: Q756T1
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ACR210C
gene id: 284811:AGOS_ACR210C
uniprot id: Q75BR1
names: Similarity
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.

284811:AGOS ADL200C
gene id: 284811:AGOS_ADL200C
uniprot id: Q75AX0
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ADR171C
gene id: 284811:AGOS_ADR171C
uniprot id: Q759V1
names: Similarity
messages: Belongs to the CBF/MAK21 family.

284811:AGOS ADL095W
gene id: 284811:AGOS_ADL095W
uniprot id: Q75AL8
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ACL072C
gene id: 284811:AGOS_ACL072C
uniprot id: Q75CJ1
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AER258C
gene id: 284811:AGOS_AER258C
uniprot id: Q756J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RTC5 family.
messages: Cytoplasm
messages: May be involved in a process influencing telomere capping.

284811:AGOS AGL093W
gene id: 284811:AGOS_AGL093W
uniprot id: Q9HF56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Involved in development of cell polarity during the cell division cycle. Required for the establishment of actin polarization in germ cells.

284811:AGOS AEL331W
gene id: 284811:AGOS_AEL331W
uniprot id: Q758T3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
messages: Nucleus

284811:AGOS AGR026C
gene id: 284811:AGOS_AGR026C
uniprot id: Q750C9
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Stimulates the activity of serine palmitoyltransferase (SPT).

284811:AGOS AFR354C
gene id: 284811:AGOS_AFR354C
uniprot id: Q753G0
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.

284811:AGOS ABR081C
gene id: 284811:AGOS_ABR081C
uniprot id: Q75DE6
names: Similarity
messages: Belongs to the EIS1 family.

284811:AGOS ACR125W
gene id: 284811:AGOS_ACR125W
uniprot id: Q75BZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSBP family.
messages: Membrane

284811:AGOS ACR051C
gene id: 284811:AGOS_ACR051C
uniprot id: Q75C65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

284811:AGOS AEL128C
gene id: 284811:AGOS_AEL128C
uniprot id: Q757Y8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
messages: Chromosome
messages: Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.
messages: Nucleus
messages: The AWS and SET domains are necessary for transcription repression.

284811:AGOS ADR152C
gene id: 284811:AGOS_ADR152C
uniprot id: Q759X1
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

284811:AGOS AFL029W
gene id: 284811:AGOS_AFL029W
uniprot id: Q754V0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RMD9 family.
messages: Binds the 3'-UTR of mitochondrial mRNAs. Involved in the processing or stability of mitochondrial mRNAs.
messages: Mitochondrion inner membrane
messages: Monomer.
messages: Phosphorylated. Phosphorylation promotes binding to RNA.

284811:AGOS ADR243C
gene id: 284811:AGOS_ADR243C
uniprot id: Q759N2
names: Similarity
messages: Belongs to the CCDC25 family.

284811:AGOS ADL220C
gene id: 284811:AGOS_ADL220C
uniprot id: Q75AZ0
names: Similarity
messages: Belongs to the PIGH family.

284811:AGOS ABR155C
gene id: 284811:AGOS_ABR155C
uniprot id: Q75D68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

284811:AGOS AGR327C
gene id: 284811:AGOS_AGR327C
uniprot id: Q74Z79
names: Subcellular Location Annotation
messages: Membrane
messages: cell wall

284811:AGOS AEL166C
gene id: 284811:AGOS_AEL166C
uniprot id: Q758B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose (By similarity).

284811:AGOS AFR400C
gene id: 284811:AGOS_AFR400C
uniprot id: Q753Q9
names: Similarity
messages: Belongs to the cytochrome P450 family.

284811:AGOS AGR068W
gene id: 284811:AGOS_AGR068W
uniprot id: Q74ZZ0
names: Function
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.
messages: Responsible for the reduction of the keto group on the C-3 of sterols.

284811:AGOS AEL010W
gene id: 284811:AGOS_AEL010W
uniprot id: Q757M1
names: Similarity
messages: Belongs to the PP2C family.

284811:AGOS ADL380W
gene id: 284811:AGOS_ADL380W
uniprot id: Q75BE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.

284811:AGOS AER038C
gene id: 284811:AGOS_AER038C
uniprot id: Q757H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPP381 family.
messages: Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome.
messages: Component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA (By similarity).
messages: Nucleus

284811:AGOS ADL182C
gene id: 284811:AGOS_ADL182C
uniprot id: Q75AV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS AFR696C
gene id: 284811:AGOS_AFR696C
uniprot id: Q751X9
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

284811:AGOS AER068C
gene id: 284811:AGOS_AER068C
uniprot id: Q757E5
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ACR055W
gene id: 284811:AGOS_ACR055W
uniprot id: Q75C61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Cytoplasm

284811:AGOS AFR595W
gene id: 284811:AGOS_AFR595W
uniprot id: Q752I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Probable transporter.
messages: Vacuole membrane

284811:AGOS ACL014C
gene id: 284811:AGOS_ACL014C
uniprot id: Q75CC3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Membrane
messages: Required for vacuolar protein sorting.
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

284811:AGOS ACR056W
gene id: 284811:AGOS_ACR056W
uniprot id: Q75C60
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

284811:AGOS ADL098C
gene id: 284811:AGOS_ADL098C
uniprot id: Q75AM1
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ACL181C
gene id: 284811:AGOS_ACL181C
uniprot id: Q75CX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 48 family.
messages: Membrane

284811:AGOS ABR095C
gene id: 284811:AGOS_ABR095C
uniprot id: Q75DD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

284811:AGOS ADR091W
gene id: 284811:AGOS_ADR091W
uniprot id: Q75A29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

284811:AGOS ADR043W
gene id: 284811:AGOS_ADR043W
uniprot id: Q75A75
names: Function
names: Similarity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.

284811:AGOS AGR164C
gene id: 284811:AGOS_AGR164C
uniprot id: Q74ZN4
names: Similarity
messages: Belongs to the HscB family.

284811:AGOS ACL003C
gene id: 284811:AGOS_ACL003C
uniprot id: Q75CB4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.
messages: The DHHC domain is required for palmitoyltransferase activity.

284811:AGOS AGL082W
gene id: 284811:AGOS_AGL082W
uniprot id: Q751A1
names: Function
names: Similarity
messages: Belongs to the UDPGP type 1 family.
messages: Plays a central role as a glucosyl donor in cellular metabolic pathways.

284811:AGOS ADL364C
gene id: 284811:AGOS_ADL364C
uniprot id: Q75BD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Nucleus

284811:AGOS AAR130C
gene id: 284811:AGOS_AAR130C
uniprot id: Q75EF1
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

284811:AGOS AAR008W
gene id: 284811:AGOS_AAR008W
uniprot id: Q75ES1
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

284811:AGOS ACL118C
gene id: 284811:AGOS_ACL118C
uniprot id: Q75CN7
names: Similarity
messages: Belongs to the cytidylyltransferase family.

284811:AGOS AEL181C
gene id: 284811:AGOS_AEL181C
uniprot id: Q758E3
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

284811:AGOS ACR043W
gene id: 284811:AGOS_ACR043W
uniprot id: Q75C73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAD2 family.
messages: Nucleus

284811:AGOS AAR029W
gene id: 284811:AGOS_AAR029W
uniprot id: Q75EQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DASH complex DAM1 family.
messages: Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
messages: Nucleus
messages: The DASH complex oligomerizes to form rings that encircle the microtubules.
messages: kinetochore
messages: spindle

284811:AGOS AFR146W
gene id: 284811:AGOS_AFR146W
uniprot id: Q754C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS ABR009W
gene id: 284811:AGOS_ABR009W
uniprot id: Q75DL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Membrane

284811:AGOS AGL338W
gene id: 284811:AGOS_AGL338W
uniprot id: Q751N5
names: Similarity
messages: Belongs to the ELP6 family.

284811:AGOS ADR135W
gene id: 284811:AGOS_ADR135W
uniprot id: Q759Y8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEN15 family.
messages: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body (By similarity).
messages: tRNA splicing endonuclease is a heterotetramer composed of SEN2, SEN15, SEN34 and SEN54. Interacts directly with SEN34 (By similarity).

284811:AGOS AFR537W
gene id: 284811:AGOS_AFR537W
uniprot id: Q752N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

284811:AGOS AMI008W
gene id: 284811:AGOS_AMI008W
uniprot id: P62513
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
messages: Mitochondrion inner membrane
messages: The protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.

284811:AGOS AAL117C
gene id: 284811:AGOS_AAL117C
uniprot id: Q75F45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

284811:AGOS ACL050W
gene id: 284811:AGOS_ACL050W
uniprot id: Q75CG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle. Interacts with NOP7 and RRP1. Interacts with RSA4 (via WD repeats).
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).
messages: nucleolus

284811:AGOS ADR357C
gene id: 284811:AGOS_ADR357C
uniprot id: Q759C0
names: Subcellular Location Annotation
messages: Mitochondrion

284811:AGOS ADR251W
gene id: 284811:AGOS_ADR251W
uniprot id: Q759M5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

284811:AGOS AFR677C
gene id: 284811:AGOS_AFR677C
uniprot id: Q751Z8
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR011W
gene id: 284811:AGOS_AFR011W
uniprot id: Q754R1
names: Similarity
messages: Belongs to the alkylbase DNA glycosidase AlkA family.

284811:AGOS ADR169C
gene id: 284811:AGOS_ADR169C
uniprot id: Q759V3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

284811:AGOS AFR549W
gene id: 284811:AGOS_AFR549W
uniprot id: Q752M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S10 family.
messages: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).
messages: trans-Golgi network membrane

284811:AGOS AER139C
gene id: 284811:AGOS_AER139C
uniprot id: Q756X5
names: Function
names: Similarity
messages: Belongs to the dihydroxyacetone kinase (DAK) family.
messages: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.

284811:AGOS AFR176W
gene id: 284811:AGOS_AFR176W
uniprot id: Q753Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

284811:AGOS ABR120C
gene id: 284811:AGOS_ABR120C
uniprot id: Q75DA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

284811:AGOS ACR263C
gene id: 284811:AGOS_ACR263C
uniprot id: Q75BK8
names: Similarity
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

284811:AGOS ABR221C
gene id: 284811:AGOS_ABR221C
uniprot id: Q75D01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS ACR004W
gene id: 284811:AGOS_ACR004W
uniprot id: Q75CA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS ADR344W
gene id: 284811:AGOS_ADR344W
uniprot id: Q759D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus

284811:AGOS AGL187W
gene id: 284811:AGOS_AGL187W
uniprot id: Q750X6
names: Similarity
messages: Belongs to the dopey family.

284811:AGOS ACL017C
gene id: 284811:AGOS_ACL017C
uniprot id: Q75CC6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by ESA1 and/or GCN5 to form H2A.ZK3Ac, H2A.ZK8Ac, H2A.ZK10Ac and H2A.ZK14Ac once deposited into chromatin. Acetylation is required for function at telomeres. H2A.ZK14Ac is acetylated at the promoters of active genes (By similarity).
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Interacts also with RBP1/DNA-directed RNA polymerase II largest subunit (By similarity).
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2A.ZK3ac = acetylated Lys-4; H2A.ZK8ac = acetylated Lys-9; H2A.ZK10ac = acetylated Lys-11; H2A.ZK14ac = acetylated Lys-15.
messages: Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability (By similarity).

284811:AGOS AFL008W
gene id: 284811:AGOS_AFL008W
uniprot id: Q754S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: Nucleus

284811:AGOS AAR070C
gene id: 284811:AGOS_AAR070C
uniprot id: Q75EK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS ABR189W
gene id: 284811:AGOS_ABR189W
uniprot id: Q75D34
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Contains a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2).
messages: Cytoplasm
messages: Membrane
messages: Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage (By similarity).
messages: The L/FRRG motif is essential for the cytoplasm to vacuole transport (Cvt) pathway and for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium and in both its recruitment to and dissociation from the PAS under starvation conditions.
messages: Vacuole membrane

284811:AGOS AFL023C
gene id: 284811:AGOS_AFL023C
uniprot id: Q754U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSA1 family.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

284811:AGOS AER011C
gene id: 284811:AGOS_AER011C
uniprot id: Q757K1
names: Similarity
messages: Belongs to the TCP11 family.

284811:AGOS AER187W
gene id: 284811:AGOS_AER187W
uniprot id: Q756R7
names: Similarity
messages: Belongs to the heat shock protein 70 family.

284811:AGOS AGL277W
gene id: 284811:AGOS_AGL277W
uniprot id: Q751I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

284811:AGOS ADL052W
gene id: 284811:AGOS_ADL052W
uniprot id: Q75AH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MRG family.
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
messages: Nucleus

284811:AGOS AGL014C
gene id: 284811:AGOS_AGL014C
uniprot id: Q750G7
names: Similarity
messages: Belongs to the RRP12 family.

284811:AGOS AGR039C
gene id: 284811:AGOS_AGR039C
uniprot id: Q750B8
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADR069C
gene id: 284811:AGOS_ADR069C
uniprot id: Q75A50
names: Similarity
messages: Belongs to the SAS10 family.

284811:AGOS AGL314C
gene id: 284811:AGOS_AGL314C
uniprot id: Q751L5
names: Similarity
messages: Belongs to the peptidase C12 family.

284811:AGOS ADR118C
gene id: 284811:AGOS_ADR118C
uniprot id: Q75A12
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

284811:AGOS AEL319C
gene id: 284811:AGOS_AEL319C
uniprot id: Q758S2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX9 family.
messages: Interacts with the 35S, 23S and 20S pre-rRNAs and with the U3 snoRNA.
messages: Involved in ribosome biogenesis. Required for normal pre-rRNA processing in internal transcribed spacer 1 (ITS1). May be involved in the movements of the replication forks (By similarity).
messages: nucleolus

284811:AGOS AER304C
gene id: 284811:AGOS_AER304C
uniprot id: Q756G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPL family. TOM1/PTR1 subfamily.
messages: Probable ubiquitin ligase protein, which may be involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins.
messages: nucleolus

284811:AGOS AGL330W
gene id: 284811:AGOS_AGL330W
uniprot id: Q751M7
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ABL185C
gene id: 284811:AGOS_ABL185C
uniprot id: Q75E55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AFL162C
gene id: 284811:AGOS_AFL162C
uniprot id: Q755I5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

284811:AGOS ADL301C
gene id: 284811:AGOS_ADL301C
uniprot id: Q75B73
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

284811:AGOS ADL293W
gene id: 284811:AGOS_ADL293W
uniprot id: Q75B65
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Endosome membrane
messages: Preautophagosomal structure membrane
messages: Required for cytoplasm to vacuole transport (Cvt), pexophagy and mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Functions in protein retrieval from the endocytic pathway (By similarity).
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization of ATG20 to the perivacuolar punctate structures.

284811:AGOS AEL265W
gene id: 284811:AGOS_AEL265W
uniprot id: Q758U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Membrane

284811:AGOS AER358C
gene id: 284811:AGOS_AER358C
uniprot id: Q756A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

284811:AGOS AAR143W
gene id: 284811:AGOS_AAR143W
uniprot id: Q75ED8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

284811:AGOS AGL023W
gene id: 284811:AGOS_AGL023W
uniprot id: Q750H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Nucleus

284811:AGOS AGR366W
gene id: 284811:AGOS_AGR366W
uniprot id: Q74Z40
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AGL184W
gene id: 284811:AGOS_AGL184W
uniprot id: Q750X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the crooked-neck family.
messages: Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity).
messages: Nucleus

284811:AGOS AFL197C
gene id: 284811:AGOS_AFL197C
uniprot id: Q755L1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homodimer.
messages: Mitochondrion
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

284811:AGOS ABR122C
gene id: 284811:AGOS_ABR122C
uniprot id: Q75DA2
names: Similarity
messages: Belongs to the PdxS/SNZ family.

284811:AGOS AFR199C
gene id: 284811:AGOS_AFR199C
uniprot id: Q753X3
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

284811:AGOS AAR067W
gene id: 284811:AGOS_AAR067W
uniprot id: Q75EL2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

284811:AGOS AAL169C
gene id: 284811:AGOS_AAL169C
uniprot id: Q75F85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC3 family.
messages: Nucleus

284811:AGOS AFR236C
gene id: 284811:AGOS_AFR236C
uniprot id: Q753T9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPT transporter family. SLC35D subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homooligomer.
messages: Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.

284811:AGOS ABR005C
gene id: 284811:AGOS_ABR005C
uniprot id: Q75DL3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

284811:AGOS AFR410W
gene id: 284811:AGOS_AFR410W
uniprot id: Q753B4
names: Cofactor
messages: Binds 1 zinc ion per subunit.

284811:AGOS AAR085W
gene id: 284811:AGOS_AAR085W
uniprot id: Q75EJ4
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ABR178C
gene id: 284811:AGOS_ABR178C
uniprot id: Q75D45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

284811:AGOS AAL056C
gene id: 284811:AGOS_AAL056C
uniprot id: Q75EY4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

284811:AGOS ADR072C
gene id: 284811:AGOS_ADR072C
uniprot id: Q75A47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP14 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).
messages: nucleolus

284811:AGOS AGR145C
gene id: 284811:AGOS_AGR145C
uniprot id: Q74ZQ3
names: Similarity
messages: Belongs to the MYG1 family.

284811:AGOS ADL390W
gene id: 284811:AGOS_ADL390W
uniprot id: Q75BF4
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

284811:AGOS ACR288W
gene id: 284811:AGOS_ACR288W
uniprot id: Q75BI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

284811:AGOS AER335W
gene id: 284811:AGOS_AER335W
uniprot id: Q756D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Cytoplasm
messages: Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.

284811:AGOS ACL110W
gene id: 284811:AGOS_ACL110W
uniprot id: Q75CM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

284811:AGOS ABR232C
gene id: 284811:AGOS_ABR232C
uniprot id: Q75CZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFU1 family.
messages: Endosome
messages: Inhibitor of the DOA4 deubiquitinase involved in the regulation of protein degradation by the proteasome and maintenance of a normal level of free ubiquitin.

284811:AGOS ABR198C
gene id: 284811:AGOS_ABR198C
uniprot id: Q75D24
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

284811:AGOS AFL182C
gene id: 284811:AGOS_AFL182C
uniprot id: Q755Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS AGL225C
gene id: 284811:AGOS_AGL225C
uniprot id: Q751D1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Associated with pre-ribosomal particles.
messages: Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

284811:AGOS ADL136C
gene id: 284811:AGOS_ADL136C
uniprot id: Q75AQ6
names: Subcellular Location Annotation
messages: Peroxisome membrane

284811:AGOS AFR541W
gene id: 284811:AGOS_AFR541W
uniprot id: Q752N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRG7 family.
messages: Mitochondrion

284811:AGOS ADL373W
gene id: 284811:AGOS_ADL373W
uniprot id: Q75BD7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

284811:AGOS AFR159C
gene id: 284811:AGOS_AFR159C
uniprot id: Q754H9
names: Similarity
messages: Belongs to the cyclin family.

284811:AGOS ADR170C
gene id: 284811:AGOS_ADR170C
uniprot id: Q759V2
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

284811:AGOS AGR270W
gene id: 284811:AGOS_AGR270W
uniprot id: Q74ZC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS ADR354W
gene id: 284811:AGOS_ADR354W
uniprot id: Q759C3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

284811:AGOS ACL151C
gene id: 284811:AGOS_ACL151C
uniprot id: Q75CS0
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

284811:AGOS ADL298C
gene id: 284811:AGOS_ADL298C
uniprot id: Q75B70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CLASP family.
messages: Interacts with microtubules.
messages: Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity).
messages: Nucleus
messages: cytoskeleton
messages: spindle

284811:AGOS AER357C
gene id: 284811:AGOS_AER357C
uniprot id: Q756B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

284811:AGOS ACR030W
gene id: 284811:AGOS_ACR030W
uniprot id: Q75C86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

284811:AGOS ABR184C
gene id: 284811:AGOS_ABR184C
uniprot id: Q9HF53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Mitochondrion

284811:AGOS ADR114C
gene id: 284811:AGOS_ADR114C
uniprot id: Q75A10
names: Similarity
messages: Belongs to the VPS72/YL1 family.

284811:AGOS AGL112C
gene id: 284811:AGOS_AGL112C
uniprot id: Q750Q4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns. Also required for efficient mitochondrial translation (By similarity).
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: Mitochondrion matrix
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

284811:AGOS ADL170C
gene id: 284811:AGOS_ADL170C
uniprot id: Q75AU0
names: Similarity
messages: Belongs to the KRI1 family.

284811:AGOS AAL141C
gene id: 284811:AGOS_AAL141C
uniprot id: Q75F69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

284811:AGOS AFR051W
gene id: 284811:AGOS_AFR051W
uniprot id: Q754M1
names: Similarity
messages: Belongs to the actin family.

284811:AGOS AGR252C
gene id: 284811:AGOS_AGR252C
uniprot id: Q74ZE7
names: Similarity
messages: Belongs to the RRP15 family.

284811:AGOS AEL277C
gene id: 284811:AGOS_AEL277C
uniprot id: Q758N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).
messages: Belongs to the ATG13 family. Fungi subfamily.
messages: Cytoplasm
messages: Interacts with ATG1 to form the ATG1-ATG13 kinase complex.
messages: Preautophagosomal structure

284811:AGOS ADL033W
gene id: 284811:AGOS_ADL033W
uniprot id: Q75AF0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

284811:AGOS AAL149C
gene id: 284811:AGOS_AAL149C
uniprot id: Q75F77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF alpha subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

284811:AGOS ABR191C
gene id: 284811:AGOS_ABR191C
uniprot id: Q75D32
names: Similarity
messages: Belongs to the MGR2 family.

284811:AGOS ADL092W
gene id: 284811:AGOS_ADL092W
uniprot id: Q75B02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Membrane

284811:AGOS ABL058C
gene id: 284811:AGOS_ABL058C
uniprot id: Q75DT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

284811:AGOS AGR008W
gene id: 284811:AGOS_AGR008W
uniprot id: Q750E7
names: Similarity
messages: Belongs to the peptidase M24B family.

284811:AGOS AER083C
gene id: 284811:AGOS_AER083C
uniprot id: Q757D0
names: Function
names: Similarity
messages: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

284811:AGOS AFL131W
gene id: 284811:AGOS_AFL131W
uniprot id: Q755F4
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.

284811:AGOS AGR016W
gene id: 284811:AGOS_AGR016W
uniprot id: Q750D9
names: Similarity
messages: Belongs to the PITHD1 family.

284811:AGOS AFR501C
gene id: 284811:AGOS_AFR501C
uniprot id: Q752S2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

284811:AGOS AEL208W
gene id: 284811:AGOS_AEL208W
uniprot id: Q758H0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Heterooctamer of 4 alpha and 4 beta chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

284811:AGOS AFR133C
gene id: 284811:AGOS_AFR133C
uniprot id: Q754D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

284811:AGOS AAR058W
gene id: 284811:AGOS_AAR058W
uniprot id: Q75EM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTR86 family.
messages: Cytoplasm
messages: Essential protein which may be involved in threonine biosynthesis.

284811:AGOS AER210C
gene id: 284811:AGOS_AER210C
uniprot id: Q756P4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

284811:AGOS ACL141C
gene id: 284811:AGOS_ACL141C
uniprot id: Q75CR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

284811:AGOS ACR130W
gene id: 284811:AGOS_ACR130W
uniprot id: Q75BZ0
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.

284811:AGOS AEL312C
gene id: 284811:AGOS_AEL312C
uniprot id: Q758R5
names: Similarity
messages: Belongs to the SUN family.

284811:AGOS AGR156C
gene id: 284811:AGOS_AGR156C
uniprot id: Q74ZP2
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AGL320C
gene id: 284811:AGOS_AGL320C
uniprot id: Q751L7
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

284811:AGOS ABL201W
gene id: 284811:AGOS_ABL201W
uniprot id: Q75E71
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

284811:AGOS AFR383C
gene id: 284811:AGOS_AFR383C
uniprot id: Q753D3
names: Similarity
messages: Belongs to the AIM32 family.

284811:AGOS AFL228W
gene id: 284811:AGOS_AFL228W
uniprot id: Q755P1
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

284811:AGOS AFR293C
gene id: 284811:AGOS_AFR293C
uniprot id: Q753L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).

284811:AGOS AEL220C
gene id: 284811:AGOS_AEL220C
uniprot id: Q758I2
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

284811:AGOS AEL150W
gene id: 284811:AGOS_AEL150W
uniprot id: Q758D8
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL39 family.
messages: Interacts with YIH1.

284811:AGOS AGL027W
gene id: 284811:AGOS_AGL027W
uniprot id: Q750H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

284811:AGOS AEL188W
gene id: 284811:AGOS_AEL188W
uniprot id: Q758F0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Homotetramer.
messages: In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.
messages: Interconversion of serine and glycine.
messages: Mitochondrion

284811:AGOS AFR405W
gene id: 284811:AGOS_AFR405W
uniprot id: Q753B9
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

284811:AGOS AGL047C
gene id: 284811:AGOS_AGL047C
uniprot id: Q750J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS ADR161W
gene id: 284811:AGOS_ADR161W
uniprot id: Q759W1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.

284811:AGOS AFL177W
gene id: 284811:AGOS_AFL177W
uniprot id: Q755K0
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ACR274W
gene id: 284811:AGOS_ACR274W
uniprot id: Q75BJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM34 family.
messages: Involved in pre-25S rRNA processing.
messages: nucleolus

284811:AGOS AFR094C
gene id: 284811:AGOS_AFR094C
uniprot id: Q754I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

284811:AGOS AGL241W
gene id: 284811:AGOS_AGL241W
uniprot id: Q751E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM44 family.
messages: Cytoplasm
messages: Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.

284811:AGOS AER218C
gene id: 284811:AGOS_AER218C
uniprot id: Q756N6
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.
messages: Homotetramer.

284811:AGOS ABR202C
gene id: 284811:AGOS_ABR202C
uniprot id: Q75D20
names: Function
names: Subcellular Location Annotation
messages: Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH as CTD kinase activity and DNA-dependent ATPase activity, and is essential for polymerase II transcription (By similarity).
messages: Nucleus

284811:AGOS ACL036W
gene id: 284811:AGOS_ACL036W
uniprot id: Q75CF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GET2 family.
messages: Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.

284811:AGOS AFR328C
gene id: 284811:AGOS_AFR328C
uniprot id: Q753I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: Required for pre-18S rRNA processing. May bind microtubules (By similarity).
messages: nucleolus

284811:AGOS ADR176W
gene id: 284811:AGOS_ADR176W
uniprot id: Q759U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.
messages: Self-associates. Interacts with NDL1 and dynein.
messages: cytoskeleton
messages: spindle pole

284811:AGOS AER130W
gene id: 284811:AGOS_AER130W
uniprot id: Q756Y4
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AFL189W
gene id: 284811:AGOS_AFL189W
uniprot id: Q755K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

284811:AGOS AFR039C
gene id: 284811:AGOS_AFR039C
uniprot id: Q754N3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

284811:AGOS ACR007W
gene id: 284811:AGOS_ACR007W
uniprot id: Q75CA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Nucleus

284811:AGOS ADL315C
gene id: 284811:AGOS_ADL315C
uniprot id: Q75B85
names: Similarity
messages: Belongs to the protein kinase superfamily.

284811:AGOS AFR374C
gene id: 284811:AGOS_AFR374C
uniprot id: Q753E2
names: Similarity
messages: Belongs to the dpy-30 family.

284811:AGOS ABL023W
gene id: 284811:AGOS_ABL023W
uniprot id: Q75DP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

284811:AGOS ADR314C
gene id: 284811:AGOS_ADR314C
uniprot id: Q759G2
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

284811:AGOS AGL268C
gene id: 284811:AGOS_AGL268C
uniprot id: Q751H4
names: Similarity
messages: Belongs to the TTC4 family.

284811:AGOS AGR323C
gene id: 284811:AGOS_AGR323C
uniprot id: Q74Z83
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

284811:AGOS AEL270W
gene id: 284811:AGOS_AEL270W
uniprot id: Q758V8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HDA2/3 family. HDA3 subfamily.
messages: Nucleus
messages: Probable component of some histone deacetylase complex.
messages: Required for activity of histone deacetylase complexes that are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity).

284811:AGOS ADL222W
gene id: 284811:AGOS_ADL222W
uniprot id: Q75AZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FYV10 family.
messages: Cytoplasm
messages: Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.
messages: Nucleus

284811:AGOS AAR036W
gene id: 284811:AGOS_AAR036W
uniprot id: Q75EP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

284811:AGOS AEL137W
gene id: 284811:AGOS_AEL137W
uniprot id: Q757Z7
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

284811:AGOS AFR419C
gene id: 284811:AGOS_AFR419C
uniprot id: Q753A5
names: Similarity
messages: Belongs to the actin family. ARP3 subfamily.

284811:AGOS ADR145C
gene id: 284811:AGOS_ADR145C
uniprot id: Q759X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

284811:AGOS AGR001W
gene id: 284811:AGOS_AGR001W
uniprot id: Q750F4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LOC1 family.
messages: Component of the 66S pre-ribosomal particle.
messages: Required for efficient assembly and nuclear export of the 60S ribosomal subunit.
messages: nucleolus

284811:AGOS ADR202C
gene id: 284811:AGOS_ADR202C
uniprot id: Q759S1
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

284811:AGOS AEL189W
gene id: 284811:AGOS_AEL189W
uniprot id: Q758F1
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADR112W
gene id: 284811:AGOS_ADR112W
uniprot id: Q75A02
names: Similarity
messages: Belongs to the VPS52 family.

284811:AGOS AFR619W
gene id: 284811:AGOS_AFR619W
uniprot id: Q752F7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SOP4 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the export of PMA1, possibly through the monitoring or assisting of PMA1 folding and acquisition of competence to enter vesicles.

284811:AGOS ACL042W
gene id: 284811:AGOS_ACL042W
uniprot id: Q75CG1
names: Similarity
messages: Belongs to the YOS1 family.

284811:AGOS AGR359C
gene id: 284811:AGOS_AGR359C
uniprot id: Q74Z47
names: Function
names: Similarity
messages: Belongs to the AB hydrolase superfamily.
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity).

284811:AGOS AFL191W
gene id: 284811:AGOS_AFL191W
uniprot id: Q755K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

284811:AGOS ACR074W
gene id: 284811:AGOS_ACR074W
uniprot id: Q75C43
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Endosome membrane
messages: Preautophagosomal structure membrane
messages: Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), autophagy, mitophagy, and pexophagy.
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.
messages: cytosol

284811:AGOS AGR144C
gene id: 284811:AGOS_AGR144C
uniprot id: Q9HF75
names: Function
messages: GTPase-activating protein (GAP) for RHO proteins. Required for polarized growth and maintenance of cell polarity.

284811:AGOS AGL344C
gene id: 284811:AGOS_AGL344C
uniprot id: Q751S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

284811:AGOS AEL030W
gene id: 284811:AGOS_AEL030W
uniprot id: Q757P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

284811:AGOS AFR195W
gene id: 284811:AGOS_AFR195W
uniprot id: Q753X7
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

284811:AGOS AGR126C
gene id: 284811:AGOS_AGR126C
uniprot id: Q74ZS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond. Involved in cell wall biosynthesis (By similarity).

284811:AGOS ACL005C
gene id: 284811:AGOS_ACL005C
uniprot id: Q75CF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Nucleus

284811:AGOS AAL011C
gene id: 284811:AGOS_AAL011C
uniprot id: Q75ET5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs (By similarity).
messages: nucleolus

284811:AGOS ABL003C
gene id: 284811:AGOS_ABL003C
uniprot id: Q75DM0
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR090W
gene id: 284811:AGOS_AFR090W
uniprot id: Q754Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AAR116W
gene id: 284811:AGOS_AAR116W
uniprot id: Q75EU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.
messages: Nucleus

284811:AGOS AGR081C
gene id: 284811:AGOS_AGR081C
uniprot id: Q74ZX7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

284811:AGOS ADR180C
gene id: 284811:AGOS_ADR180C
uniprot id: Q759U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AFR036C
gene id: 284811:AGOS_AFR036C
uniprot id: Q754N6
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR420W
gene id: 284811:AGOS_AFR420W
uniprot id: Q753A4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

284811:AGOS ADL289C
gene id: 284811:AGOS_ADL289C
uniprot id: Q75B61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

284811:AGOS AER020W
gene id: 284811:AGOS_AER020W
uniprot id: Q757J3
names: Similarity
messages: Belongs to the BRX1 family.

284811:AGOS ABL208W
gene id: 284811:AGOS_ABL208W
uniprot id: Q75E74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid transfer protein required for autophagosome completion and peroxisome degradation. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region. The latter binding is assisted by an ATG18-PtdIns3P interaction. ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.
messages: Preautophagosomal structure membrane

284811:AGOS AEL275C
gene id: 284811:AGOS_AEL275C
uniprot id: Q758N0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.

284811:AGOS AAL036W
gene id: 284811:AGOS_AAL036W
uniprot id: Q75EW4
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

284811:AGOS AFR358W
gene id: 284811:AGOS_AFR358W
uniprot id: Q753F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

284811:AGOS ACL122W
gene id: 284811:AGOS_ACL122W
uniprot id: Q75CP1
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

284811:AGOS ACL173C
gene id: 284811:AGOS_ACL173C
uniprot id: Q75CU2
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

284811:AGOS AFR503W
gene id: 284811:AGOS_AFR503W
uniprot id: Q752S0
names: Similarity
messages: Belongs to the PRP18 family.

284811:AGOS AFR026C
gene id: 284811:AGOS_AFR026C
uniprot id: Q754P6
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

284811:AGOS AGL265W
gene id: 284811:AGOS_AGL265W
uniprot id: Q751H1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ODC antizyme family.
messages: Interacts with ODC and thereby sterically blocks ODC homodimerization.
messages: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.

284811:AGOS ABL210C
gene id: 284811:AGOS_ABL210C
uniprot id: Q75E76
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AEL078C
gene id: 284811:AGOS_AEL078C
uniprot id: Q757U0
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

284811:AGOS ACR072C
gene id: 284811:AGOS_ACR072C
uniprot id: Q75C45
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S2 family.

284811:AGOS AFR578C
gene id: 284811:AGOS_AFR578C
uniprot id: Q752J6
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADL204W
gene id: 284811:AGOS_ADL204W
uniprot id: Q75AX4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

284811:AGOS AER062C
gene id: 284811:AGOS_AER062C
uniprot id: Q757F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

284811:AGOS AFR551W
gene id: 284811:AGOS_AFR551W
uniprot id: Q752M3
names: Similarity
messages: Belongs to the peptidase C19 family.

284811:AGOS AER284W
gene id: 284811:AGOS_AER284W
uniprot id: Q756X1
names: Subcellular Location Annotation
messages: nuclear pore complex

284811:AGOS ACR078W
gene id: 284811:AGOS_ACR078W
uniprot id: Q75C39
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription (By similarity).
messages: Associates with the nuclear pore complex.
messages: Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
messages: Cytoplasm
messages: Nucleus membrane
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nuclear pore complex

284811:AGOS AER448W
gene id: 284811:AGOS_AER448W
uniprot id: Q755S0
names: Subcellular Location Annotation
messages: Cytoplasm

284811:AGOS AFR273W
gene id: 284811:AGOS_AFR273W
uniprot id: Q753N9
names: Similarity
messages: Belongs to the XPO2/CSE1 family.

284811:AGOS ADR081C
gene id: 284811:AGOS_ADR081C
uniprot id: Q75A38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Regulates the cell cycle in a nutrient dependent manner.

284811:AGOS ACR040W
gene id: 284811:AGOS_ACR040W
uniprot id: Q75C76
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity).
messages: Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
messages: Interacts with the U3 and U14 snoRNAs. Associates with pre-ribosomal complexes (By similarity).
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

284811:AGOS ADL395C
gene id: 284811:AGOS_ADL395C
uniprot id: D8FGF0
uniprot id: Q755R1
names: Function
names: Similarity
messages: Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.
messages: Belongs to the SUI1 family.

284811:AGOS ACR046W
gene id: 284811:AGOS_ACR046W
uniprot id: Q75C70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP9 family.
messages: RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit (By similarity).
messages: nucleolus

284811:AGOS ADL311W
gene id: 284811:AGOS_ADL311W
uniprot id: Q75B83
names: Similarity
messages: Belongs to the small Tim family.

284811:AGOS AER202C
gene id: 284811:AGOS_AER202C
uniprot id: Q756Q2
names: Similarity
messages: Belongs to the PPP phosphatase family.

284811:AGOS ADR396W
gene id: 284811:AGOS_ADR396W
uniprot id: Q758Y2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

284811:AGOS ADR012C
gene id: 284811:AGOS_ADR012C
uniprot id: Q75AA6
names: Similarity
messages: Belongs to the SEC3 family.

284811:AGOS AGR055C
gene id: 284811:AGOS_AGR055C
uniprot id: Q750A2
names: Similarity
messages: Belongs to the FMO family.

284811:AGOS ADL347C
gene id: 284811:AGOS_ADL347C
uniprot id: Q75BB4
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS ABL038W
gene id: 284811:AGOS_ABL038W
uniprot id: Q75DQ5
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

284811:AGOS AFR418W
gene id: 284811:AGOS_AFR418W
uniprot id: Q753A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

284811:AGOS ADL039C
gene id: 284811:AGOS_ADL039C
uniprot id: Q75AF7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.

284811:AGOS AFR500W
gene id: 284811:AGOS_AFR500W
uniprot id: Q752S3
names: Subcellular Location Annotation
messages: Peroxisome membrane

284811:AGOS AAR192C
gene id: 284811:AGOS_AAR192C
uniprot id: Q75E88
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AEL070W
gene id: 284811:AGOS_AEL070W
uniprot id: Q757T2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity).
messages: Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA (By similarity).
messages: nucleolus

284811:AGOS AAL013W
gene id: 284811:AGOS_AAL013W
uniprot id: O60028
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.
messages: Mitochondrion

284811:AGOS AFR675W
gene id: 284811:AGOS_AFR675W
uniprot id: Q752A0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

284811:AGOS ADL127C
gene id: 284811:AGOS_ADL127C
uniprot id: Q75AP7
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

284811:AGOS ADR253W
gene id: 284811:AGOS_ADR253W
uniprot id: Q759M3
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

284811:AGOS ADL226C
gene id: 284811:AGOS_ADL226C
uniprot id: Q75AZ6
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

284811:AGOS ADR127W
gene id: 284811:AGOS_ADR127W
uniprot id: Q759Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

284811:AGOS AAL153C
gene id: 284811:AGOS_AAL153C
uniprot id: Q75F81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels.
messages: Belongs to the ADIPOR family.
messages: Endoplasmic reticulum membrane

284811:AGOS AAL136C
gene id: 284811:AGOS_AAL136C
uniprot id: Q75F64
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

284811:AGOS AFR586W
gene id: 284811:AGOS_AFR586W
uniprot id: Q752I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

284811:AGOS AFR123W
gene id: 284811:AGOS_AFR123W
uniprot id: Q754E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diphthine synthase family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

284811:AGOS AER337W
gene id: 284811:AGOS_AER337W
uniprot id: Q756D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain).
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

284811:AGOS ADR045W
gene id: 284811:AGOS_ADR045W
uniprot id: Q75A73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21. Interacts with preproteins in transit (By similarity).
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex (By similarity).
messages: Mitochondrion inner membrane

284811:AGOS AGR176C
gene id: 284811:AGOS_AGR176C
uniprot id: Q74ZM2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BUR kinase complex.
messages: Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity).
messages: Nucleus

284811:AGOS ACR073C
gene id: 284811:AGOS_ACR073C
uniprot id: Q75C44
names: Similarity
messages: Belongs to the peptidase S9B family.

284811:AGOS AFR727W
gene id: 284811:AGOS_AFR727W
uniprot id: Q751U8
names: Similarity
messages: Belongs to the RPAP1 family.

284811:AGOS AFL118W
gene id: 284811:AGOS_AFL118W
uniprot id: Q755E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

284811:AGOS AFR480C
gene id: 284811:AGOS_AFR480C
uniprot id: Q752U3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCM1 family.
messages: Mitochondrion
messages: RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts. Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome (By similarity).

284811:AGOS AER152W
gene id: 284811:AGOS_AER152W
uniprot id: Q756V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AGL050C
gene id: 284811:AGOS_AGL050C
uniprot id: Q750K1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

284811:AGOS ACL187W
gene id: 284811:AGOS_ACL187W
uniprot id: Q75CV3
names: Subcellular Location Annotation
messages: Cytoplasm

284811:AGOS ADL074W
gene id: 284811:AGOS_ADL074W
uniprot id: Q75AK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

284811:AGOS AFR527W
gene id: 284811:AGOS_AFR527W
uniprot id: Q752P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

284811:AGOS ADL014W
gene id: 284811:AGOS_ADL014W
uniprot id: Q75AD1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.
messages: Cytoplasm

284811:AGOS AFL067W
gene id: 284811:AGOS_AFL067W
uniprot id: Q754Z3
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AEL007W
gene id: 284811:AGOS_AEL007W
uniprot id: Q757M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

284811:AGOS AEL102W
gene id: 284811:AGOS_AEL102W
uniprot id: Q757W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

284811:AGOS AFR529W
gene id: 284811:AGOS_AFR529W
uniprot id: Q752P4
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

284811:AGOS AFR138W
gene id: 284811:AGOS_AFR138W
uniprot id: Q754D2
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer.

284811:AGOS AAL054W
gene id: 284811:AGOS_AAL054W
uniprot id: Q75EY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS41 family.
messages: Involved in telomere length regulation.
messages: Mitochondrion

284811:AGOS AER133C
gene id: 284811:AGOS_AER133C
uniprot id: Q756Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus
messages: ORC is composed of six subunits.

284811:AGOS AGL134C
gene id: 284811:AGOS_AGL134C
uniprot id: Q750S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pseudouridine synthase RluA family.
messages: Mitochondrion
messages: Pseudouridylate synthase responsible for the pseudouridine-2819 formation in mitochondrial 21S rRNA. May modulate the efficiency or the fidelity of the mitochondrial translation machinery.

284811:AGOS AFR280W
gene id: 284811:AGOS_AFR280W
uniprot id: Q753N2
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

284811:AGOS ADR358W
gene id: 284811:AGOS_ADR358W
uniprot id: Q759B9
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

284811:AGOS AFR568C
gene id: 284811:AGOS_AFR568C
uniprot id: Q752K6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

284811:AGOS ADR041W
gene id: 284811:AGOS_ADR041W
uniprot id: Q75A77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Nucleus

284811:AGOS AGR020C
gene id: 284811:AGOS_AGR020C
uniprot id: Q750D5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNU71 family.
messages: Component of the U1 snRNP particle, a subcomplex of the spliceosome.
messages: Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway (By similarity).
messages: Cytoplasm
messages: Nucleus

284811:AGOS AFR044C
gene id: 284811:AGOS_AFR044C
uniprot id: Q754M8
names: Function
names: Similarity
messages: Belongs to the endosulfine family.
messages: Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.

284811:AGOS ACL130C
gene id: 284811:AGOS_ACL130C
uniprot id: Q75CP9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

284811:AGOS AEL343C
gene id: 284811:AGOS_AEL343C
uniprot id: Q758U5
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

284811:AGOS AAR122C
gene id: 284811:AGOS_AAR122C
uniprot id: Q75EF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AAR057W
gene id: 284811:AGOS_AAR057W
uniprot id: Q75EM2
names: Similarity
messages: Belongs to the WD repeat PWP2 family.

284811:AGOS ACR164C
gene id: 284811:AGOS_ACR164C
uniprot id: Q75BV7
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

284811:AGOS ABR071W
gene id: 284811:AGOS_ABR071W
uniprot id: Q75DF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

284811:AGOS ACL174W
gene id: 284811:AGOS_ACL174W
uniprot id: Q75CU3
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

284811:AGOS AER317W
gene id: 284811:AGOS_AER317W
uniprot id: Q756E8
names: Similarity
messages: Belongs to the UTP6 family.

284811:AGOS AAR001C
gene id: 284811:AGOS_AAR001C
uniprot id: Q75ES8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

284811:AGOS AFR718W
gene id: 284811:AGOS_AFR718W
uniprot id: Q751V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

284811:AGOS AEL338C
gene id: 284811:AGOS_AEL338C
uniprot id: Q758U0
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

284811:AGOS ADL261C
gene id: 284811:AGOS_ADL261C
uniprot id: Q75B38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

284811:AGOS AEL079W
gene id: 284811:AGOS_AEL079W
uniprot id: Q757U1
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADR361W
gene id: 284811:AGOS_ADR361W
uniprot id: Q759B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SNW family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

284811:AGOS ADL075W
gene id: 284811:AGOS_ADL075W
uniprot id: Q75AK2
names: Similarity
messages: Belongs to the cyclin family.

284811:AGOS AAL154C
gene id: 284811:AGOS_AAL154C
uniprot id: Q75F96
names: Similarity
messages: Belongs to the SDO1/SBDS family.

284811:AGOS AFR399W
gene id: 284811:AGOS_AFR399W
uniprot id: Q753R0
names: Similarity
messages: Belongs to the IUNH family.

284811:AGOS AER457W
gene id: 284811:AGOS_AER457W
uniprot id: D8FGF0
uniprot id: Q755R1
names: Function
names: Similarity
messages: Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.
messages: Belongs to the SUI1 family.

284811:AGOS ACR087C
gene id: 284811:AGOS_ACR087C
uniprot id: Q75C30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Tetramer of two alpha and two beta subunits.

284811:AGOS AFR728W
gene id: 284811:AGOS_AFR728W
uniprot id: Q751U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRE28 family.
messages: Nucleus membrane
messages: Required for kinetochore binding by a discrete subset of kMAPs and motors. Involved in kinetochore-microtubule binding and the spindle assembly checkpoint (By similarity).
messages: kinetochore
messages: spindle pole body

284811:AGOS AFL221C
gene id: 284811:AGOS_AFL221C
uniprot id: Q755N4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.
messages: Associates with polysomes.
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

284811:AGOS AFR246C
gene id: 284811:AGOS_AFR246C
uniprot id: Q753T0
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADL169W
gene id: 284811:AGOS_ADL169W
uniprot id: Q75AT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

284811:AGOS AAR133W
gene id: 284811:AGOS_AAR133W
uniprot id: Q75EE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAK10 family.
messages: Cytoplasm

284811:AGOS AER225W
gene id: 284811:AGOS_AER225W
uniprot id: Q756M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSBP family.
messages: Membrane

284811:AGOS AGL145W
gene id: 284811:AGOS_AGL145W
uniprot id: Q750T4
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

284811:AGOS AGR143W
gene id: 284811:AGOS_AGR143W
uniprot id: E7FHS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

284811:AGOS AAL086W
gene id: 284811:AGOS_AAL086W
uniprot id: Q75F14
names: Similarity
messages: Belongs to the glutaredoxin family.

284811:AGOS AFR610W
gene id: 284811:AGOS_AFR610W
uniprot id: Q752G6
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

284811:AGOS AGL101C
gene id: 284811:AGOS_AGL101C
uniprot id: Q751B3
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

284811:AGOS AGR011W
gene id: 284811:AGOS_AGR011W
uniprot id: Q750E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.
messages: Nucleus

284811:AGOS AFR214C
gene id: 284811:AGOS_AFR214C
uniprot id: Q753V8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

284811:AGOS ADR364W
gene id: 284811:AGOS_ADR364W
uniprot id: Q759B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

284811:AGOS AEL021C
gene id: 284811:AGOS_AEL021C
uniprot id: Q757N3
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

284811:AGOS ACL182C
gene id: 284811:AGOS_ACL182C
uniprot id: Q75CX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

284811:AGOS ADL228C
gene id: 284811:AGOS_ADL228C
uniprot id: Q75AZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
messages: Belongs to the COG6 family.
messages: Golgi apparatus membrane

284811:AGOS AGR134W
gene id: 284811:AGOS_AGR134W
uniprot id: Q74ZR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

284811:AGOS AEL073C
gene id: 284811:AGOS_AEL073C
uniprot id: Q757T5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

284811:AGOS AMI005W
gene id: 284811:AGOS_AMI005W
uniprot id: Q75G40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase protein 8 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 18 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i, j and k.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrion membrane

284811:AGOS AGR047W
gene id: 284811:AGOS_AGR047W
uniprot id: Q750B0
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AER265W
gene id: 284811:AGOS_AER265W
uniprot id: Q756X4
names: Similarity
messages: Belongs to the PPP phosphatase family.

284811:AGOS AFL031W
gene id: 284811:AGOS_AFL031W
uniprot id: Q754V2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERT1/acuK family.
messages: Nucleus
messages: Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity).

284811:AGOS ACL070C
gene id: 284811:AGOS_ACL070C
uniprot id: Q75CI9
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

284811:AGOS AFR084C
gene id: 284811:AGOS_AFR084C
uniprot id: Q754J0
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

284811:AGOS AER076C
gene id: 284811:AGOS_AER076C
uniprot id: Q757D7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

284811:AGOS AER074W
gene id: 284811:AGOS_AER074W
uniprot id: Q757D9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRE1 family.
messages: E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
messages: Nucleus

284811:AGOS AGL143C
gene id: 284811:AGOS_AGL143C
uniprot id: Q750T2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

284811:AGOS ABR083C
gene id: 284811:AGOS_ABR083C
uniprot id: Q75DE4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CSE4/CENPA and H4 assembled in one CSE4-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with the inner kinetochore.
messages: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).
messages: Nucleus
messages: Ubiquitinated. Is degraded through ubiquitin-mediated proteolysis when not protected by its association to the kinetochore.
messages: centromere

284811:AGOS AFR136C
gene id: 284811:AGOS_AFR136C
uniprot id: Q754D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

284811:AGOS AGL103W
gene id: 284811:AGOS_AGL103W
uniprot id: Q751B5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

284811:AGOS ABR228C
gene id: 284811:AGOS_ABR228C
uniprot id: Q75CZ4
names: Similarity
messages: Belongs to the multicopper oxidase family.

284811:AGOS ADL045W
gene id: 284811:AGOS_ADL045W
uniprot id: Q75AG3
names: Subcellular Location Annotation
messages: Nucleus membrane

284811:AGOS AEL327W
gene id: 284811:AGOS_AEL327W
uniprot id: Q758S9
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AFR665C
gene id: 284811:AGOS_AFR665C
uniprot id: Q752B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Mitochondrion inner membrane

284811:AGOS ADR417W
gene id: 284811:AGOS_ADR417W
uniprot id: Q758W1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

284811:AGOS ADR374C
gene id: 284811:AGOS_ADR374C
uniprot id: Q759A3
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

284811:AGOS AGR235W
gene id: 284811:AGOS_AGR235W
uniprot id: Q74ZH2
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AGL041C
gene id: 284811:AGOS_AGL041C
uniprot id: Q750J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane

284811:AGOS AGL080C
gene id: 284811:AGOS_AGL080C
uniprot id: Q751A4
names: Function
names: Similarity
messages: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

284811:AGOS ACL129W
gene id: 284811:AGOS_ACL129W
uniprot id: Q75CP8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Binds 1 AMP per subunit.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

284811:AGOS AFR265C
gene id: 284811:AGOS_AFR265C
uniprot id: Q753P7
names: Similarity
messages: Belongs to the RMD1/sif2 family.

284811:AGOS AGR363W
gene id: 284811:AGOS_AGR363W
uniprot id: Q74Z43
names: Similarity
messages: Belongs to the PP2C family.

284811:AGOS AFR557C
gene id: 284811:AGOS_AFR557C
uniprot id: Q752L7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
messages: nucleolus

284811:AGOS ADR305C
gene id: 284811:AGOS_ADR305C
uniprot id: Q759I3
names: Similarity
messages: Belongs to the TCF25 family.

284811:AGOS AFL111W
gene id: 284811:AGOS_AFL111W
uniprot id: Q755D4
names: Similarity
messages: Belongs to the CBP3 family.

284811:AGOS AER437C
gene id: 284811:AGOS_AER437C
uniprot id: Q755T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.

284811:AGOS AEL325W
gene id: 284811:AGOS_AEL325W
uniprot id: Q758S7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the large ribosomal subunit.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Nucleus

284811:AGOS AER247W
gene id: 284811:AGOS_AER247W
uniprot id: Q756K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

284811:AGOS AER033W
gene id: 284811:AGOS_AER033W
uniprot id: Q757I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS9 family.
messages: Mitochondrion

284811:AGOS AFL209W
gene id: 284811:AGOS_AFL209W
uniprot id: Q755M3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ALB1 family.
messages: Component of the nucleoplasmic and cytoplasmic pre-60S ribosomal particles.
messages: Cytoplasm
messages: Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).
messages: Nucleus

284811:AGOS AGL128W
gene id: 284811:AGOS_AGL128W
uniprot id: Q751A8
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

284811:AGOS AGR028C
gene id: 284811:AGOS_AGR028C
uniprot id: Q750C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

284811:AGOS AFR085W
gene id: 284811:AGOS_AFR085W
uniprot id: Q754I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

284811:AGOS AGR106C
gene id: 284811:AGOS_AGR106C
uniprot id: Q74ZU2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP15 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking.
messages: Present with 4540 molecules/cell in log phase SD medium.

284811:AGOS AER199C
gene id: 284811:AGOS_AER199C
uniprot id: Q756Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS37 family.
messages: Component of the mitochondrial small ribosomal subunit.
messages: Involved in mitochondrial genome encoded proteins translation.
messages: Mitochondrion

284811:AGOS AGL269W
gene id: 284811:AGOS_AGL269W
uniprot id: Q751H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Nucleus
messages: spindle

284811:AGOS AEL198W
gene id: 284811:AGOS_AEL198W
uniprot id: Q758G0
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

284811:AGOS ABR067C
gene id: 284811:AGOS_ABR067C
uniprot id: Q75DF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Peroxisome membrane
messages: Required for protein import into peroxisomes.

284811:AGOS ACR225C
gene id: 284811:AGOS_ACR225C
uniprot id: Q75BP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

284811:AGOS ABR224W
gene id: 284811:AGOS_ABR224W
uniprot id: Q75CZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane

284811:AGOS AER184W
gene id: 284811:AGOS_AER184W
uniprot id: Q756S0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer.

284811:AGOS ADL176W
gene id: 284811:AGOS_ADL176W
uniprot id: Q75AU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 2 family.
messages: Nucleus

284811:AGOS AEL295C
gene id: 284811:AGOS_AEL295C
uniprot id: Q758P8
names: Subcellular Location Annotation
messages: Nucleus

284811:AGOS AAL016C
gene id: 284811:AGOS_AAL016C
uniprot id: Q9HF61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD3 family.
messages: Cell septum
messages: Cell tip
messages: Required for proper septum positioning and septum construction during septation. Acts as a landmark to mark sites for future septation, and as part of a scaffold that recruits components of the contractile ring to the site of septation. Not required to determine the site of lateral branch formation.

284811:AGOS AFR592W
gene id: 284811:AGOS_AFR592W
uniprot id: Q752I3
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

284811:AGOS ADR179C
gene id: 284811:AGOS_ADR179C
uniprot id: Q759U4
names: Similarity
messages: Belongs to the TAF11 family.

284811:AGOS AGL363C
gene id: 284811:AGOS_AGL363C
uniprot id: Q751Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

284811:AGOS AEL224W
gene id: 284811:AGOS_AEL224W
uniprot id: Q758I6
names: Subcellular Location Annotation
messages: Cytoplasm

284811:AGOS ABR229C
gene id: 284811:AGOS_ABR229C
uniprot id: Q75CZ3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

284811:AGOS AFR426C
gene id: 284811:AGOS_AFR426C
uniprot id: Q752Z8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
messages: Cytoplasm
messages: Nucleus

284811:AGOS AFR006C
gene id: 284811:AGOS_AFR006C
uniprot id: Q754R6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WRB/GET1 family.
messages: Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.

284811:AGOS AEL115C
gene id: 284811:AGOS_AEL115C
uniprot id: Q758E1
names: Similarity
messages: Belongs to the protein kinase superfamily.

284811:AGOS AER022W
gene id: 284811:AGOS_AER022W
uniprot id: Q757J1
names: Similarity
messages: Belongs to the peptidase S10 family.

284811:AGOS ABL146C
gene id: 284811:AGOS_ABL146C
uniprot id: Q75E19
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: Catalytic component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response.
messages: Component of the COP9 signalosome (CSN) complex.
messages: Cytoplasm
messages: Nucleus
messages: The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).

284811:AGOS AFL046W
gene id: 284811:AGOS_AFL046W
uniprot id: Q754W3
names: Function
names: Similarity
messages: Belongs to the HisA/HisF family.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.
messages: In the C-terminal section; belongs to the HisA/HisF family.

284811:AGOS AGL119C
gene id: 284811:AGOS_AGL119C
uniprot id: Q750R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).
messages: May form heterododecamers with RVB2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).
messages: Nucleus

284811:AGOS AGL042W
gene id: 284811:AGOS_AGL042W
uniprot id: Q750J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 28 family.
messages: Endoplasmic reticulum
messages: Heterodimer with ALG14 to form a functional enzyme.
messages: Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway (By similarity).

284811:AGOS ADL164C
gene id: 284811:AGOS_ADL164C
uniprot id: Q75AT4
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

284811:AGOS AGL149C
gene id: 284811:AGOS_AGL149C
uniprot id: Q750T8
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR439C
gene id: 284811:AGOS_AFR439C
uniprot id: Q752Y4
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

284811:AGOS AFR207C
gene id: 284811:AGOS_AFR207C
uniprot id: Q753W5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b560 family.
messages: Membrane
messages: The heme is bound between the two transmembrane subunits.

284811:AGOS AAL164C
gene id: 284811:AGOS_AAL164C
uniprot id: Q75F95
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in ribosome assembly.
messages: Associates with pre-ribosomal particles.
messages: Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

284811:AGOS ACL137C
gene id: 284811:AGOS_ACL137C
uniprot id: Q75CQ6
names: Similarity
messages: Belongs to the ZPR1 family.

284811:AGOS ADR412C
gene id: 284811:AGOS_ADR412C
uniprot id: Q758W6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

284811:AGOS AEL100W
gene id: 284811:AGOS_AEL100W
uniprot id: Q757W2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis (By similarity).
messages: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

284811:AGOS AGL057W
gene id: 284811:AGOS_AGL057W
uniprot id: Q750K8
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
messages: Can also use Mn(2+) ion.

284811:AGOS ACL134C
gene id: 284811:AGOS_ACL134C
uniprot id: Q75CQ3
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

284811:AGOS AGR101C
gene id: 284811:AGOS_AGR101C
uniprot id: Q74ZU7
names: Similarity
messages: Belongs to the RecA family. DMC1 subfamily.

284811:AGOS ADR144C
gene id: 284811:AGOS_ADR144C
uniprot id: Q759X9
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

284811:AGOS AFR124W
gene id: 284811:AGOS_AFR124W
uniprot id: Q754E6
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

284811:AGOS AFL148C
gene id: 284811:AGOS_AFL148C
uniprot id: Q8J2M3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.

284811:AGOS AFL080W
gene id: 284811:AGOS_AFL080W
uniprot id: Q755A5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity).
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

284811:AGOS AAR188W
gene id: 284811:AGOS_AAR188W
uniprot id: Q75E92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

284811:AGOS AER359W
gene id: 284811:AGOS_AER359W
uniprot id: Q756A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

284811:AGOS ADL338C
gene id: 284811:AGOS_ADL338C
uniprot id: Q75BA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Endoplasmic reticulum membrane
messages: Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER (By similarity).

284811:AGOS AFR219C
gene id: 284811:AGOS_AFR219C
uniprot id: Q753V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DLT1 family.
messages: Membrane
messages: Required for growth under high-pressure and low-temperature conditions.

284811:AGOS ABR148W
gene id: 284811:AGOS_ABR148W
uniprot id: Q75D76
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

284811:AGOS AFL055W
gene id: 284811:AGOS_AFL055W
uniprot id: Q754X1
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Cytoplasm
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.
messages: Positively regulated by the regulatory subunit PAN3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

284811:AGOS AAR100C
gene id: 284811:AGOS_AAR100C
uniprot id: Q75EH9
names: Similarity
messages: Belongs to the cyclin family.

284811:AGOS AFR642C
gene id: 284811:AGOS_AFR642C
uniprot id: D8FGF0
uniprot id: Q755R1
names: Function
names: Similarity
messages: Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.
messages: Belongs to the SUI1 family.

284811:AGOS ABR150C
gene id: 284811:AGOS_ABR150C
uniprot id: Q75D73
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

284811:AGOS AGL296W
gene id: 284811:AGOS_AGL296W
uniprot id: Q751K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

284811:AGOS AFR672C
gene id: 284811:AGOS_AFR672C
uniprot id: Q752A3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the timeless family.
messages: Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.
messages: Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
messages: Nucleus

284811:AGOS AEL335C
gene id: 284811:AGOS_AEL335C
uniprot id: Q758T7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM10 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
messages: Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
messages: Mitochondrion outer membrane

284811:AGOS AGR360C
gene id: 284811:AGOS_AGR360C
uniprot id: Q74Z46
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

284811:AGOS ABL105W
gene id: 284811:AGOS_ABL105W
uniprot id: Q75DX8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

284811:AGOS AER036W
gene id: 284811:AGOS_AER036W
uniprot id: Q757H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 14, 12 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).
messages: Nucleus

284811:AGOS ADL168C
gene id: 284811:AGOS_ADL168C
uniprot id: Q75AT8
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

284811:AGOS AMI003W
gene id: 284811:AGOS_AMI003W
uniprot id: Q75G34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

284811:AGOS AER060W
gene id: 284811:AGOS_AER060W
uniprot id: Q757F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP10 family.
messages: Involved in assembly of the mitochondrial F1-F0 complex.
messages: Mitochondrion inner membrane

284811:AGOS AGL328C
gene id: 284811:AGOS_AGL328C
uniprot id: Q751M5
names: Similarity
messages: Belongs to the peptidase S10 family.

284811:AGOS AEL258W
gene id: 284811:AGOS_AEL258W
uniprot id: Q758L9
names: Similarity
messages: Belongs to the AAA ATPase family. PCH2 subfamily.

284811:AGOS ACL028W
gene id: 284811:AGOS_ACL028W
uniprot id: Q75CD7
names: Similarity
messages: Belongs to the peptidase M24B family.

284811:AGOS AER274W
gene id: 284811:AGOS_AER274W
uniprot id: Q756I7
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR346W
gene id: 284811:AGOS_AFR346W
uniprot id: Q753G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

284811:AGOS ABR165W
gene id: 284811:AGOS_ABR165W
uniprot id: Q75D58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

284811:AGOS AGL115W
gene id: 284811:AGOS_AGL115W
uniprot id: Q750Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes. Regulates also the sphingolipid metabolism (By similarity).

284811:AGOS AGR187W
gene id: 284811:AGOS_AGR187W
uniprot id: Q74ZL1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.
messages: cytosol

284811:AGOS ACL002C
gene id: 284811:AGOS_ACL002C
uniprot id: Q75CB3
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS AFR657C
gene id: 284811:AGOS_AFR657C
uniprot id: Q752B8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-B family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA polymerase II participates in chromosomal DNA replication.
messages: Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4 (By similarity).
messages: Nucleus
messages: The CysA-type zinc finger is required for PCNA-binding.
messages: The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.

284811:AGOS ABR173C
gene id: 284811:AGOS_ABR173C
uniprot id: Q75D50
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ACR012C
gene id: 284811:AGOS_ACR012C
uniprot id: Q75CA0
names: Similarity
messages: Belongs to the peptidase S8 family.

284811:AGOS ADR203C
gene id: 284811:AGOS_ADR203C
uniprot id: Q759S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLD7 family.
messages: Nucleus
messages: Required for the proper initiation of DNA replication. Required for mitochondrial morphology (By similarity).
messages: spindle pole

284811:AGOS AFL199C
gene id: 284811:AGOS_AFL199C
uniprot id: Q755L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

284811:AGOS AFR135W
gene id: 284811:AGOS_AFR135W
uniprot id: Q754D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Nucleus
messages: Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex.

284811:AGOS ADR252W
gene id: 284811:AGOS_ADR252W
uniprot id: Q759M4
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

284811:AGOS AER167W
gene id: 284811:AGOS_AER167W
uniprot id: Q756T6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

284811:AGOS AGR036W
gene id: 284811:AGOS_AGR036W
uniprot id: Q750C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

284811:AGOS AER414W
gene id: 284811:AGOS_AER414W
uniprot id: Q755V4
names: Similarity
messages: Belongs to the XPG/RAD2 endonuclease family.

284811:AGOS AEL049W
gene id: 284811:AGOS_AEL049W
uniprot id: Q757R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

284811:AGOS AGR003W
gene id: 284811:AGOS_AGR003W
uniprot id: Q750F2
names: Similarity
messages: Belongs to the PrpD family.

284811:AGOS AEL151C
gene id: 284811:AGOS_AEL151C
uniprot id: Q752J5
names: Miscellaneous
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.
messages: There are two genes for S22 in A.gossypii.

284811:AGOS AGR243W
gene id: 284811:AGOS_AGR243W
uniprot id: Q74ZG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cut8/STS1 family.
messages: Binds the proteasome.
messages: Cytoplasm
messages: Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity).
messages: Nucleus

284811:AGOS AFR221C
gene id: 284811:AGOS_AFR221C
uniprot id: Q753V4
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

284811:AGOS ACR091W
gene id: 284811:AGOS_ACR091W
uniprot id: Q75C26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Cytoplasm
messages: Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
messages: Interacts with NAR1.
messages: Nucleus

284811:AGOS ADR077C
gene id: 284811:AGOS_ADR077C
uniprot id: Q75A42
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

284811:AGOS AER408W
gene id: 284811:AGOS_AER408W
uniprot id: Q755W0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity).
messages: Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

284811:AGOS AFL117C
gene id: 284811:AGOS_AFL117C
uniprot id: Q755E0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.

284811:AGOS AEL229W
gene id: 284811:AGOS_AEL229W
uniprot id: Q758J1
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

284811:AGOS AAL182W
gene id: 284811:AGOS_AAL182W
uniprot id: Q75FB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Nucleus

284811:AGOS AGR396W
gene id: 284811:AGOS_AGR396W
uniprot id: Q74Z11
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

284811:AGOS ABL017C
gene id: 284811:AGOS_ABL017C
uniprot id: Q75DN4
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

284811:AGOS AFL099W
gene id: 284811:AGOS_AFL099W
uniprot id: Q755C2
names: Similarity
messages: Belongs to the TYW1 family.

284811:AGOS ADL156C
gene id: 284811:AGOS_ADL156C
uniprot id: Q75AS6
names: Subcellular Location Annotation
messages: Membrane

284811:AGOS ADR368W
gene id: 284811:AGOS_ADR368W
uniprot id: Q759A9
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

284811:AGOS AAL014C
gene id: 284811:AGOS_AAL014C
uniprot id: O60029
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane

284811:AGOS AFL106C
gene id: 284811:AGOS_AFL106C
uniprot id: Q755C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion