274537:BIU88 RS01285
gene id: 274537:BIU88_RS01285
uniprot id: A0A1D8CVL1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

274537:BIU88 RS06030
gene id: 274537:BIU88_RS06030
uniprot id: A0A1D8D3W3
names: Cofactor
names: PTM
names: Subcellular Location Annotation
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.
messages: Periplasm

274537:BIU88 RS10940
gene id: 274537:BIU88_RS10940
uniprot id: A0A1D8D705
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

274537:BIU88 RS08590
gene id: 274537:BIU88_RS08590
uniprot id: A0A1D8D1B4
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS06795
gene id: 274537:BIU88_RS06795
uniprot id: A0A1D8D2Q2
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

274537:BIU88 RS09955
gene id: 274537:BIU88_RS09955
uniprot id: A0A1D8D6K9
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

274537:BIU88 RS00230
gene id: 274537:BIU88_RS00230
uniprot id: A0A1D8CX98
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

274537:BIU88 RS07875
gene id: 274537:BIU88_RS07875
uniprot id: A0A1D8D1Q6
names: Similarity
messages: Belongs to the TolB family.

274537:BIU88 RS01820
gene id: 274537:BIU88_RS01820
uniprot id: A0A1D8CXX9
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

274537:BIU88 RS00395
gene id: 274537:BIU88_RS00395
uniprot id: A0A1D8CY64
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

274537:BIU88 RS04585
gene id: 274537:BIU88_RS04585
uniprot id: A0A1D8D799
names: Similarity
messages: Belongs to the LOG family.

274537:BIU88 RS08035
gene id: 274537:BIU88_RS08035
uniprot id: A0A1D8D7B7
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

274537:BIU88 RS01060
gene id: 274537:BIU88_RS01060
uniprot id: A0A1D8CVI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

274537:BIU88 RS02025
gene id: 274537:BIU88_RS02025
uniprot id: A0A1D8D2H6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

274537:BIU88 RS10200
gene id: 274537:BIU88_RS10200
uniprot id: A0A1D8CZV7
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS07130
gene id: 274537:BIU88_RS07130
uniprot id: A0A1D8D1M8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterotetramer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits of ACCase subunit beta/alpha.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the AccA family.
messages: In the N-terminal section; belongs to the AccD/PCCB family.

274537:BIU88 RS01995
gene id: 274537:BIU88_RS01995
uniprot id: A0A1D8CVW7
names: Similarity
messages: Belongs to the HypD family.

274537:BIU88 RS10700
gene id: 274537:BIU88_RS10700
uniprot id: A0A1D8D277
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS05890
gene id: 274537:BIU88_RS05890
uniprot id: A0A1D8CXQ5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS11695
gene id: 274537:BIU88_RS11695
uniprot id: A0A1D8D9V5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

274537:BIU88 RS10610
gene id: 274537:BIU88_RS10610
uniprot id: A0A1D8D3Z1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

274537:BIU88 RS04410
gene id: 274537:BIU88_RS04410
uniprot id: A0A1D8CZA0
names: Function
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.
messages: Involved in bacteriochlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.

274537:BIU88 RS04925
gene id: 274537:BIU88_RS04925
uniprot id: A0A1D8D0B0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

274537:BIU88 RS02615
gene id: 274537:BIU88_RS02615
uniprot id: A0A1D8CW72
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

274537:BIU88 RS01665
gene id: 274537:BIU88_RS01665
uniprot id: A0A1D8D3X7
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

274537:BIU88 RS03150
gene id: 274537:BIU88_RS03150
uniprot id: A0A1D8D2V9
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

274537:BIU88 RS02295
gene id: 274537:BIU88_RS02295
uniprot id: A0A1D8D2L0
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS04710
gene id: 274537:BIU88_RS04710
uniprot id: A0A1D8D077
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

274537:BIU88 RS01210
gene id: 274537:BIU88_RS01210
uniprot id: A0A1D8D279
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

274537:BIU88 RS07865
gene id: 274537:BIU88_RS07865
uniprot id: A0A1D8CYU0
names: Similarity
messages: Belongs to the Pal lipoprotein family.

274537:BIU88 RS02955
gene id: 274537:BIU88_RS02955
uniprot id: A0A1D8D1A2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

274537:BIU88 RS11580
gene id: 274537:BIU88_RS11580
uniprot id: A0A1D8D0J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

274537:BIU88 RS04810
gene id: 274537:BIU88_RS04810
uniprot id: A0A1D8CZG4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

274537:BIU88 RS09015
gene id: 274537:BIU88_RS09015
uniprot id: A0A1D8D4S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

274537:BIU88 RS07285
gene id: 274537:BIU88_RS07285
uniprot id: A0A1D8D4A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

274537:BIU88 RS00595
gene id: 274537:BIU88_RS00595
uniprot id: A0A1D8D1Z4
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

274537:BIU88 RS03090
gene id: 274537:BIU88_RS03090
uniprot id: A0A1D8CWF1
names: Similarity
messages: Belongs to the P(II) protein family.

274537:BIU88 RS07210
gene id: 274537:BIU88_RS07210
uniprot id: A0A1D8D5U0
names: Similarity
messages: Belongs to the thioredoxin family.

274537:BIU88 RS03140
gene id: 274537:BIU88_RS03140
uniprot id: A0A1D8D1C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

274537:BIU88 RS06205
gene id: 274537:BIU88_RS06205
uniprot id: A0A1D8D7Z8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS04235
gene id: 274537:BIU88_RS04235
uniprot id: A0A1D8D5Y4
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

274537:BIU88 RS04510
gene id: 274537:BIU88_RS04510
uniprot id: A0A1D8CX21
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

274537:BIU88 RS02785
gene id: 274537:BIU88_RS02785
uniprot id: A0A1D8CZE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

274537:BIU88 RS11800
gene id: 274537:BIU88_RS11800
uniprot id: A0A1D8D1V4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

274537:BIU88 RS12055
gene id: 274537:BIU88_RS12055
uniprot id: A0A1D8D4E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

274537:BIU88 RS05330
gene id: 274537:BIU88_RS05330
uniprot id: A0A1D8D7M5
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

274537:BIU88 RS03450
gene id: 274537:BIU88_RS03450
uniprot id: A0A1D8D6R1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

274537:BIU88 RS07970
gene id: 274537:BIU88_RS07970
uniprot id: A0A1D8D7B0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

274537:BIU88 RS11565
gene id: 274537:BIU88_RS11565
uniprot id: A0A1D8D332
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

274537:BIU88 RS08425
gene id: 274537:BIU88_RS08425
uniprot id: A0A1D8D193
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

274537:BIU88 RS12700
gene id: 274537:BIU88_RS12700
uniprot id: A0A1D8D3H2
names: Subcellular Location Annotation
messages: Cytoplasm

274537:BIU88 RS05205
gene id: 274537:BIU88_RS05205
uniprot id: A0A1D8D263
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

274537:BIU88 RS04965
gene id: 274537:BIU88_RS04965
uniprot id: A0A1D8CX97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

274537:BIU88 RS12595
gene id: 274537:BIU88_RS12595
uniprot id: A0A1D8D3F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

274537:BIU88 RS07545
gene id: 274537:BIU88_RS07545
uniprot id: A0A1D8D1J5
names: Similarity
messages: Belongs to the TrpF family.

274537:BIU88 RS12600
gene id: 274537:BIU88_RS12600
uniprot id: A0A1D8D7S4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

274537:BIU88 RS02695
gene id: 274537:BIU88_RS02695
uniprot id: A0A1D8D5K0
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

274537:BIU88 RS06780
gene id: 274537:BIU88_RS06780
uniprot id: A0A1D8CY73
names: Similarity
messages: Belongs to the HdrA family.

274537:BIU88 RS06135
gene id: 274537:BIU88_RS06135
uniprot id: A0A1D8D2I1
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS04515
gene id: 274537:BIU88_RS04515
uniprot id: A0A1D8D3B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

274537:BIU88 RS03245
gene id: 274537:BIU88_RS03245
uniprot id: A0A1D8D4F4
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

274537:BIU88 RS04175
gene id: 274537:BIU88_RS04175
uniprot id: A0A1D8CWX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0761 family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS05265
gene id: 274537:BIU88_RS05265
uniprot id: A0A1D8D3N1
names: Similarity
messages: Belongs to the Nth/MutY family.

274537:BIU88 RS12075
gene id: 274537:BIU88_RS12075
uniprot id: A0A1D8D9X4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

274537:BIU88 RS01940
gene id: 274537:BIU88_RS01940
uniprot id: A0A1D8CYY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

274537:BIU88 RS12685
gene id: 274537:BIU88_RS12685
uniprot id: A0A1D8D174
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

274537:BIU88 RS09390
gene id: 274537:BIU88_RS09390
uniprot id: A0A1D8CZH6
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

274537:BIU88 RS02565
gene id: 274537:BIU88_RS02565
uniprot id: A0A1D8CZ99
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

274537:BIU88 RS05400
gene id: 274537:BIU88_RS05400
uniprot id: A0A1D8D0K0
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

274537:BIU88 RS00320
gene id: 274537:BIU88_RS00320
uniprot id: A0A1D8D3H5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

274537:BIU88 RS03470
gene id: 274537:BIU88_RS03470
uniprot id: A0A1D8CZP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

274537:BIU88 RS10295
gene id: 274537:BIU88_RS10295
uniprot id: A0A1D8D8F3
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

274537:BIU88 RS11555
gene id: 274537:BIU88_RS11555
uniprot id: A0A1D8D2H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

274537:BIU88 RS07180
gene id: 274537:BIU88_RS07180
uniprot id: A0A1D8D8G4
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

274537:BIU88 RS11360
gene id: 274537:BIU88_RS11360
uniprot id: A0A1D8D0F2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

274537:BIU88 RS05750
gene id: 274537:BIU88_RS05750
uniprot id: A0A1D8D2D2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.
messages: The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
messages: The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.

274537:BIU88 RS10915
gene id: 274537:BIU88_RS10915
uniprot id: A0A1D8D9J2
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

274537:BIU88 RS11535
gene id: 274537:BIU88_RS11535
uniprot id: A0A1D8D8W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

274537:BIU88 RS12170
gene id: 274537:BIU88_RS12170
uniprot id: A0A1D8D4F5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

274537:BIU88 RS02790
gene id: 274537:BIU88_RS02790
uniprot id: A0A1D8D4B4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

274537:BIU88 RS07410
gene id: 274537:BIU88_RS07410
uniprot id: A0A1D8D1N2
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS00815
gene id: 274537:BIU88_RS00815
uniprot id: A0A1D8D1A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

274537:BIU88 RS08555
gene id: 274537:BIU88_RS08555
uniprot id: A0A1D8D3A2
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

274537:BIU88 RS02630
gene id: 274537:BIU88_RS02630
uniprot id: A0A1D8D147
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

274537:BIU88 RS06300
gene id: 274537:BIU88_RS06300
uniprot id: A0A1D8D2J7
names: Similarity
messages: Belongs to the SAICAR synthetase family.

274537:BIU88 RS02745
gene id: 274537:BIU88_RS02745
uniprot id: A0A1D8D170
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

274537:BIU88 RS03720
gene id: 274537:BIU88_RS03720
uniprot id: A0A1D8CWQ5
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

274537:BIU88 RS04020
gene id: 274537:BIU88_RS04020
uniprot id: A0A1D8CWU6
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS05745
gene id: 274537:BIU88_RS05745
uniprot id: A0A1D8D5D5
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
messages: Belongs to the RecD family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

274537:BIU88 RS06050
gene id: 274537:BIU88_RS06050
uniprot id: A0A1D8D029
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS10440
gene id: 274537:BIU88_RS10440
uniprot id: A0A1D8D2P2
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

274537:BIU88 RS05455
gene id: 274537:BIU88_RS05455
uniprot id: A0A1D8D0K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

274537:BIU88 RS09130
gene id: 274537:BIU88_RS09130
uniprot id: A0A1D8D9D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

274537:BIU88 RS10795
gene id: 274537:BIU88_RS10795
uniprot id: A0A1D8D8M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

274537:BIU88 RS02440
gene id: 274537:BIU88_RS02440
uniprot id: A0A1D8D809
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

274537:BIU88 RS00725
gene id: 274537:BIU88_RS00725
uniprot id: A0A1D8CXH7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS10790
gene id: 274537:BIU88_RS10790
uniprot id: A0A1D8D5J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

274537:BIU88 RS11935
gene id: 274537:BIU88_RS11935
uniprot id: A0A1D8D0Q9
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

274537:BIU88 RS05325
gene id: 274537:BIU88_RS05325
uniprot id: A0A1D8D670
names: Similarity
messages: Belongs to the peptidase S24 family.

274537:BIU88 RS05050
gene id: 274537:BIU88_RS05050
uniprot id: A0A1D8D3K1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

274537:BIU88 RS11650
gene id: 274537:BIU88_RS11650
uniprot id: A0A1D8D0K6
names: Similarity
messages: Belongs to the aminoglycoside phosphotransferase family.
messages: Belongs to the glycosyl hydrolase 13 family. TreS subfamily.

274537:BIU88 RS01845
gene id: 274537:BIU88_RS01845
uniprot id: A0A1D8CVV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

274537:BIU88 RS03065
gene id: 274537:BIU88_RS03065
uniprot id: A0A1D8CZI2
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

274537:BIU88 RS07445
gene id: 274537:BIU88_RS07445
uniprot id: A0A1D8D0Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

274537:BIU88 RS07595
gene id: 274537:BIU88_RS07595
uniprot id: A0A1D8D1K5
names: Similarity
messages: Belongs to the AlaDH/PNT family.

274537:BIU88 RS05525
gene id: 274537:BIU88_RS05525
uniprot id: A0A1D8D2A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

274537:BIU88 RS11620
gene id: 274537:BIU88_RS11620
uniprot id: A0A1D8D7C0
names: Similarity
messages: Belongs to the CIA30 family.

274537:BIU88 RS00085
gene id: 274537:BIU88_RS00085
uniprot id: A0A1D8CV54
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

274537:BIU88 RS02705
gene id: 274537:BIU88_RS02705
uniprot id: A0A1D8CW91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

274537:BIU88 RS05785
gene id: 274537:BIU88_RS05785
uniprot id: A0A1D8CZY5
names: Subcellular Location Annotation
messages: chloroplast

274537:BIU88 RS03980
gene id: 274537:BIU88_RS03980
uniprot id: A0A1D8D1Q4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

274537:BIU88 RS00025
gene id: 274537:BIU88_RS00025
uniprot id: A0A1D8D3C9
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

274537:BIU88 RS09780
gene id: 274537:BIU88_RS09780
uniprot id: A0A1D8CZN4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

274537:BIU88 RS08460
gene id: 274537:BIU88_RS08460
uniprot id: A0A1D8D9D1
names: Similarity
messages: Belongs to the AdoMet synthetase 2 family.

274537:BIU88 RS09335
gene id: 274537:BIU88_RS09335
uniprot id: A0A1D8D6B0
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

274537:BIU88 RS03970
gene id: 274537:BIU88_RS03970
uniprot id: A0A1D8CZW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS11510
gene id: 274537:BIU88_RS11510
uniprot id: A0A1D8D7A0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS03100
gene id: 274537:BIU88_RS03100
uniprot id: A0A1D8D5N4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-97 inactivates the nitrogenase reductase and regulates nitrogenase activity.

274537:BIU88 RS01040
gene id: 274537:BIU88_RS01040
uniprot id: A0A1D8D4S3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

274537:BIU88 RS03895
gene id: 274537:BIU88_RS03895
uniprot id: A0A1D8CWT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

274537:BIU88 RS00100
gene id: 274537:BIU88_RS00100
uniprot id: A0A1D8D5Q1
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS08825
gene id: 274537:BIU88_RS08825
uniprot id: A0A1D8D1P9
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

274537:BIU88 RS02610
gene id: 274537:BIU88_RS02610
uniprot id: A0A1D8CYA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

274537:BIU88 RS10850
gene id: 274537:BIU88_RS10850
uniprot id: A0A1D8D3U9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

274537:BIU88 RS02895
gene id: 274537:BIU88_RS02895
uniprot id: A0A1D8D192
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS07265
gene id: 274537:BIU88_RS07265
uniprot id: A0A1D8D1F7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

274537:BIU88 RS08835
gene id: 274537:BIU88_RS08835
uniprot id: A0A1D8CZ87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

274537:BIU88 RS12560
gene id: 274537:BIU88_RS12560
uniprot id: A0A1D8DAI5
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS07810
gene id: 274537:BIU88_RS07810
uniprot id: A0A1D8D0X5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

274537:BIU88 RS10985
gene id: 274537:BIU88_RS10985
uniprot id: A0A1D8D091
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS10900
gene id: 274537:BIU88_RS10900
uniprot id: A0A1D8D073
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

274537:BIU88 RS10475
gene id: 274537:BIU88_RS10475
uniprot id: A0A1D8D9D0
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

274537:BIU88 RS09125
gene id: 274537:BIU88_RS09125
uniprot id: A0A1D8D7W0
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

274537:BIU88 RS09615
gene id: 274537:BIU88_RS09615
uniprot id: A0A1D8D2E0
names: Similarity
messages: Belongs to the GSP E family.

274537:BIU88 RS03935
gene id: 274537:BIU88_RS03935
uniprot id: A0A1D8CWT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

274537:BIU88 RS02060
gene id: 274537:BIU88_RS02060
uniprot id: A0A1D8CZ04
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

274537:BIU88 RS07290
gene id: 274537:BIU88_RS07290
uniprot id: A0A1D8D703
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

274537:BIU88 RS02655
gene id: 274537:BIU88_RS02655
uniprot id: A0A1D8CW81
names: Similarity
messages: Belongs to the CutA family.

274537:BIU88 RS04785
gene id: 274537:BIU88_RS04785
uniprot id: A0A1D8D3F6
names: Similarity
messages: Belongs to the HdrA family.

274537:BIU88 RS08545
gene id: 274537:BIU88_RS08545
uniprot id: A0A1D8D212
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

274537:BIU88 RS02750
gene id: 274537:BIU88_RS02750
uniprot id: A0A1D8CW93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

274537:BIU88 RS11175
gene id: 274537:BIU88_RS11175
uniprot id: A0A1D8D467
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

274537:BIU88 RS04995
gene id: 274537:BIU88_RS04995
uniprot id: A0A1D8CXA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

274537:BIU88 RS09920
gene id: 274537:BIU88_RS09920
uniprot id: A0A1D8D877
names: Similarity
messages: Belongs to the citrate synthase family.

274537:BIU88 RS12080
gene id: 274537:BIU88_RS12080
uniprot id: A0A1D8D0S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

274537:BIU88 RS03225
gene id: 274537:BIU88_RS03225
uniprot id: A0A1D8CWH5
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

274537:BIU88 RS10260
gene id: 274537:BIU88_RS10260
uniprot id: A0A1D8CZX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS07275
gene id: 274537:BIU88_RS07275
uniprot id: A0A1D8D2V7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

274537:BIU88 RS07220
gene id: 274537:BIU88_RS07220
uniprot id: A0A1D8D2V0
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

274537:BIU88 RS12280
gene id: 274537:BIU88_RS12280
uniprot id: A0A1D8D4G5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

274537:BIU88 RS10735
gene id: 274537:BIU88_RS10735
uniprot id: A0A1D8D8L5
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS08605
gene id: 274537:BIU88_RS08605
uniprot id: A0A1D8D657
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

274537:BIU88 RS01150
gene id: 274537:BIU88_RS01150
uniprot id: A0A1D8D273
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS06645
gene id: 274537:BIU88_RS06645
uniprot id: A0A1D8CY57
names: Caution
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS01430
gene id: 274537:BIU88_RS01430
uniprot id: A0A1D8CYM8
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

274537:BIU88 RS00160
gene id: 274537:BIU88_RS00160
uniprot id: A0A1D8CV55
names: Similarity
messages: Belongs to the arsA ATPase family.

274537:BIU88 RS02070
gene id: 274537:BIU88_RS02070
uniprot id: A0A1D8D0U0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS12555
gene id: 274537:BIU88_RS12555
uniprot id: A0A1D8D132
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS08925
gene id: 274537:BIU88_RS08925
uniprot id: A0A1D8CZA9
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

274537:BIU88 RS11070
gene id: 274537:BIU88_RS11070
uniprot id: A0A1D8D0A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BChl C/E-binding protein family.
messages: Component of the photosynthetic apparatus.
messages: chlorosome envelope

274537:BIU88 RS00055
gene id: 274537:BIU88_RS00055
uniprot id: A0A1D8CV36
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS10585
gene id: 274537:BIU88_RS10585
uniprot id: A0A1D8D022
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

274537:BIU88 RS08500
gene id: 274537:BIU88_RS08500
uniprot id: A0A1D8D652
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

274537:BIU88 RS07870
gene id: 274537:BIU88_RS07870
uniprot id: A0A1D8D679
names: Similarity
messages: Belongs to the Pal lipoprotein family.

274537:BIU88 RS05155
gene id: 274537:BIU88_RS05155
uniprot id: A0A1D8CXD1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

274537:BIU88 RS03310
gene id: 274537:BIU88_RS03310
uniprot id: A0A1D8D2Y1
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS08570
gene id: 274537:BIU88_RS08570
uniprot id: A0A1D8D7K9
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

274537:BIU88 RS04980
gene id: 274537:BIU88_RS04980
uniprot id: A0A1D8D0C3
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

274537:BIU88 RS02495
gene id: 274537:BIU88_RS02495
uniprot id: A0A1D8CY89
names: PTM
messages: Binds 1 heme group per subunit.

274537:BIU88 RS12530
gene id: 274537:BIU88_RS12530
uniprot id: A0A1D8D2T9
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

274537:BIU88 RS02320
gene id: 274537:BIU88_RS02320
uniprot id: A0A1D8CW18
names: Similarity
messages: Belongs to the GARS family.

274537:BIU88 RS08975
gene id: 274537:BIU88_RS08975
uniprot id: A0A1D8D1H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

274537:BIU88 RS12785
gene id: 274537:BIU88_RS12785
uniprot id: A0A1D8D975
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

274537:BIU88 RS10480
gene id: 274537:BIU88_RS10480
uniprot id: A0A1D8D004
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

274537:BIU88 RS06130
gene id: 274537:BIU88_RS06130
uniprot id: A0A1D8D9B6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS04795
gene id: 274537:BIU88_RS04795
uniprot id: A0A1D8D7D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

274537:BIU88 RS10830
gene id: 274537:BIU88_RS10830
uniprot id: A0A1D8D418
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS11995
gene id: 274537:BIU88_RS11995
uniprot id: A0A1D8D4D8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ChlB/BchB/BchZ family.
messages: Binds 1 [4Fe-4S] cluster per heterodimer. The cluster is bound at the heterodimer interface by residues from both subunits.
messages: Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex.
messages: Protochlorophyllide reductase is composed of three subunits; BchL, BchN and BchB. Forms a heterotetramer of two BchB and two BchN subunits.

274537:BIU88 RS06195
gene id: 274537:BIU88_RS06195
uniprot id: A0A1D8D3X8
names: Similarity
messages: Belongs to the arsA ATPase family.

274537:BIU88 RS10780
gene id: 274537:BIU88_RS10780
uniprot id: A0A1D8D404
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

274537:BIU88 RS01685
gene id: 274537:BIU88_RS01685
uniprot id: A0A1D8D538
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

274537:BIU88 RS05930
gene id: 274537:BIU88_RS05930
uniprot id: A0A1D8D3U8
names: Similarity
messages: Belongs to the DEAD box helicase family.

274537:BIU88 RS07780
gene id: 274537:BIU88_RS07780
uniprot id: A0A1D8CYT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

274537:BIU88 RS05495
gene id: 274537:BIU88_RS05495
uniprot id: A0A1D8D7P6
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS01160
gene id: 274537:BIU88_RS01160
uniprot id: A0A1D8D5Z0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

274537:BIU88 RS06150
gene id: 274537:BIU88_RS06150
uniprot id: A0A1D8D6I2
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

274537:BIU88 RS02570
gene id: 274537:BIU88_RS02570
uniprot id: A0A1D8D485
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

274537:BIU88 RS10060
gene id: 274537:BIU88_RS10060
uniprot id: A0A1D8D6L5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

274537:BIU88 RS01460
gene id: 274537:BIU88_RS01460
uniprot id: A0A1D8D610
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

274537:BIU88 RS04015
gene id: 274537:BIU88_RS04015
uniprot id: A0A1D8CZ22
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS12090
gene id: 274537:BIU88_RS12090
uniprot id: A0A1D8D0R6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

274537:BIU88 RS07955
gene id: 274537:BIU88_RS07955
uniprot id: A0A1D8CYW1
names: Subcellular Location Annotation
messages: Cytoplasm

274537:BIU88 RS07085
gene id: 274537:BIU88_RS07085
uniprot id: A0A1D8D0J8
names: Caution
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

274537:BIU88 RS03950
gene id: 274537:BIU88_RS03950
uniprot id: A0A1D8D6Z9
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

274537:BIU88 RS11180
gene id: 274537:BIU88_RS11180
uniprot id: A0A1D8D0B9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

274537:BIU88 RS10445
gene id: 274537:BIU88_RS10445
uniprot id: A0A1D8D696
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

274537:BIU88 RS04495
gene id: 274537:BIU88_RS04495
uniprot id: A0A1D8D046
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

274537:BIU88 RS01705
gene id: 274537:BIU88_RS01705
uniprot id: A0A1D8CXW3
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

274537:BIU88 RS04635
gene id: 274537:BIU88_RS04635
uniprot id: A0A1D8D7A6
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

274537:BIU88 RS04105
gene id: 274537:BIU88_RS04105
uniprot id: A0A1D8CWV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

274537:BIU88 RS05845
gene id: 274537:BIU88_RS05845
uniprot id: A0A1D8CZZ2
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

274537:BIU88 RS11715
gene id: 274537:BIU88_RS11715
uniprot id: A0A1D8D348
names: Similarity
messages: Belongs to the UPF0166 family.

274537:BIU88 RS11635
gene id: 274537:BIU88_RS11635
uniprot id: A0A1D8D5S3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

274537:BIU88 RS05705
gene id: 274537:BIU88_RS05705
uniprot id: A0A1D8D3S8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.

274537:BIU88 RS11125
gene id: 274537:BIU88_RS11125
uniprot id: A0A1D8D0A8
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

274537:BIU88 RS12155
gene id: 274537:BIU88_RS12155
uniprot id: A0A1D8D8G1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

274537:BIU88 RS10570
gene id: 274537:BIU88_RS10570
uniprot id: A0A1D8D5H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

274537:BIU88 RS02490
gene id: 274537:BIU88_RS02490
uniprot id: A0A1D8CW48
names: Function
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.

274537:BIU88 RS00225
gene id: 274537:BIU88_RS00225
uniprot id: A0A1D8CV65
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

274537:BIU88 RS12290
gene id: 274537:BIU88_RS12290
uniprot id: A0A1D8D0W0
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.

274537:BIU88 RS10895
gene id: 274537:BIU88_RS10895
uniprot id: A0A1D8D428
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

274537:BIU88 RS12095
gene id: 274537:BIU88_RS12095
uniprot id: A0A1D8D385
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

274537:BIU88 RS09885
gene id: 274537:BIU88_RS09885
uniprot id: A0A1D8D1Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

274537:BIU88 RS05445
gene id: 274537:BIU88_RS05445
uniprot id: A0A1D8CZS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

274537:BIU88 RS01345
gene id: 274537:BIU88_RS01345
uniprot id: A0A1D8CVG3
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

274537:BIU88 RS01380
gene id: 274537:BIU88_RS01380
uniprot id: A0A1D8D0H6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

274537:BIU88 RS09815
gene id: 274537:BIU88_RS09815
uniprot id: A0A1D8D988
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS12690
gene id: 274537:BIU88_RS12690
uniprot id: A0A1D8D2W0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

274537:BIU88 RS07640
gene id: 274537:BIU88_RS07640
uniprot id: A0A1D8CYP6
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

274537:BIU88 RS00835
gene id: 274537:BIU88_RS00835
uniprot id: A0A1D8CXJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

274537:BIU88 RS09105
gene id: 274537:BIU88_RS09105
uniprot id: A0A1D8D692
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

274537:BIU88 RS01770
gene id: 274537:BIU88_RS01770
uniprot id: A0A1D8CYV9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS07655
gene id: 274537:BIU88_RS07655
uniprot id: A0A1D8D301
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

274537:BIU88 RS00380
gene id: 274537:BIU88_RS00380
uniprot id: A0A1D8D3I9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

274537:BIU88 RS06895
gene id: 274537:BIU88_RS06895
uniprot id: A0A1D8CY92
names: Similarity
messages: Belongs to the thioredoxin family.

274537:BIU88 RS04150
gene id: 274537:BIU88_RS04150
uniprot id: A0A1D8D1S9
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

274537:BIU88 RS05120
gene id: 274537:BIU88_RS05120
uniprot id: A0A1D8CXC7
names: Similarity
messages: Belongs to the sigma-54 factor family.

274537:BIU88 RS09795
gene id: 274537:BIU88_RS09795
uniprot id: A0A1D8D3Q5
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS00795
gene id: 274537:BIU88_RS00795
uniprot id: A0A1D8D3N7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

274537:BIU88 RS04985
gene id: 274537:BIU88_RS04985
uniprot id: A0A1D8D560
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

274537:BIU88 RS10710
gene id: 274537:BIU88_RS10710
uniprot id: A0A1D8D2S6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

274537:BIU88 RS08485
gene id: 274537:BIU88_RS08485
uniprot id: A0A1D8D1A3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

274537:BIU88 RS12470
gene id: 274537:BIU88_RS12470
uniprot id: A0A1D8D9Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has four main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

274537:BIU88 RS07960
gene id: 274537:BIU88_RS07960
uniprot id: A0A1D8D4F6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

274537:BIU88 RS02940
gene id: 274537:BIU88_RS02940
uniprot id: A0A1D8CZG7
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

274537:BIU88 RS12580
gene id: 274537:BIU88_RS12580
uniprot id: A0A1D8D150
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS10245
gene id: 274537:BIU88_RS10245
uniprot id: A0A1D8D9B7
names: Similarity
messages: Belongs to the peptidase S16 family.

274537:BIU88 RS07250
gene id: 274537:BIU88_RS07250
uniprot id: A0A1D8D0M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

274537:BIU88 RS07515
gene id: 274537:BIU88_RS07515
uniprot id: A0A1D8D8K2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

274537:BIU88 RS09270
gene id: 274537:BIU88_RS09270
uniprot id: A0A1D8D1L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.

274537:BIU88 RS08335
gene id: 274537:BIU88_RS08335
uniprot id: A0A1D8D7H7
names: Similarity
messages: Belongs to the DNA photolyase class-2 family.

274537:BIU88 RS02795
gene id: 274537:BIU88_RS02795
uniprot id: A0A1D8D175
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

274537:BIU88 RS03040
gene id: 274537:BIU88_RS03040
uniprot id: A0A1D8D6J4
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

274537:BIU88 RS02990
gene id: 274537:BIU88_RS02990
uniprot id: A0A1D8CYI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

274537:BIU88 RS06090
gene id: 274537:BIU88_RS06090
uniprot id: A0A1D8D6G9
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

274537:BIU88 RS00645
gene id: 274537:BIU88_RS00645
uniprot id: A0A1D8D203
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

274537:BIU88 RS01905
gene id: 274537:BIU88_RS01905
uniprot id: A0A1D8D2G1
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

274537:BIU88 RS10840
gene id: 274537:BIU88_RS10840
uniprot id: A0A1D8D5K4
names: Similarity
messages: Belongs to the MEMO1 family.

274537:BIU88 RS09045
gene id: 274537:BIU88_RS09045
uniprot id: A0A1D8D271
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS11410
gene id: 274537:BIU88_RS11410
uniprot id: A0A1D8D492
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

274537:BIU88 RS08775
gene id: 274537:BIU88_RS08775
uniprot id: A0A1D8CZ80
names: Similarity
messages: Belongs to the DapA family.

274537:BIU88 RS09250
gene id: 274537:BIU88_RS09250
uniprot id: A0A1D8D4W4
names: Similarity
messages: Belongs to the CobH/CbiC family.

274537:BIU88 RS12160
gene id: 274537:BIU88_RS12160
uniprot id: A0A1D8D392
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

274537:BIU88 RS03440
gene id: 274537:BIU88_RS03440
uniprot id: A0A1D8D2Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

274537:BIU88 RS10615
gene id: 274537:BIU88_RS10615
uniprot id: A0A1D8D020
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

274537:BIU88 RS12740
gene id: 274537:BIU88_RS12740
uniprot id: A0A1D8DA09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

274537:BIU88 RS00455
gene id: 274537:BIU88_RS00455
uniprot id: A0A1D8D633
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

274537:BIU88 RS03035
gene id: 274537:BIU88_RS03035
uniprot id: A0A1D8D5M9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mg(2+). Can also accept Mn(2+).

274537:BIU88 RS07940
gene id: 274537:BIU88_RS07940
uniprot id: A0A1D8D1Q9
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

274537:BIU88 RS12200
gene id: 274537:BIU88_RS12200
uniprot id: A0A1D8D2P3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

274537:BIU88 RS01980
gene id: 274537:BIU88_RS01980
uniprot id: A0A1D8D7Z7
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

274537:BIU88 RS00275
gene id: 274537:BIU88_RS00275
uniprot id: A0A1D8CV76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

274537:BIU88 RS06655
gene id: 274537:BIU88_RS06655
uniprot id: A0A1D8D6N6
names: Similarity
messages: Belongs to the myoviridae tail sheath protein family.

274537:BIU88 RS04035
gene id: 274537:BIU88_RS04035
uniprot id: A0A1D8D4M1
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

274537:BIU88 RS08820
gene id: 274537:BIU88_RS08820
uniprot id: A0A1D8D673
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

274537:BIU88 RS07885
gene id: 274537:BIU88_RS07885
uniprot id: A0A1D8D9C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

274537:BIU88 RS07235
gene id: 274537:BIU88_RS07235
uniprot id: A0A1D8D6Z4
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

274537:BIU88 RS09570
gene id: 274537:BIU88_RS09570
uniprot id: A0A1D8D6E9
names: Similarity
messages: Belongs to the TrbI/VirB10 family.

274537:BIU88 RS10020
gene id: 274537:BIU88_RS10020
uniprot id: A0A1D8CZR9
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS03520
gene id: 274537:BIU88_RS03520
uniprot id: A0A1D8CWL8
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

274537:BIU88 RS10880
gene id: 274537:BIU88_RS10880
uniprot id: A0A1D8D074
names: Similarity
messages: Belongs to the CinA family.

274537:BIU88 RS10835
gene id: 274537:BIU88_RS10835
uniprot id: A0A1D8D063
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

274537:BIU88 RS04245
gene id: 274537:BIU88_RS04245
uniprot id: A0A1D8CWY0
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

274537:BIU88 RS09530
gene id: 274537:BIU88_RS09530
uniprot id: A0A1D8D1S0
names: Similarity
messages: Belongs to the peptidase S24 family.

274537:BIU88 RS10950
gene id: 274537:BIU88_RS10950
uniprot id: A0A1D8D085
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

274537:BIU88 RS04180
gene id: 274537:BIU88_RS04180
uniprot id: A0A1D8CZ49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

274537:BIU88 RS03585
gene id: 274537:BIU88_RS03585
uniprot id: A0A1D8D4I2
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

274537:BIU88 RS12165
gene id: 274537:BIU88_RS12165
uniprot id: A0A1D8D7L3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

274537:BIU88 RS00895
gene id: 274537:BIU88_RS00895
uniprot id: A0A1D8CVF9
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

274537:BIU88 RS07925
gene id: 274537:BIU88_RS07925
uniprot id: A0A1D8D1P3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

274537:BIU88 RS00110
gene id: 274537:BIU88_RS00110
uniprot id: A0A1D8CX76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS05975
gene id: 274537:BIU88_RS05975
uniprot id: A0A1D8CXS8
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

274537:BIU88 RS06990
gene id: 274537:BIU88_RS06990
uniprot id: A0A1D8D473
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS07830
gene id: 274537:BIU88_RS07830
uniprot id: A0A1D8D319
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

274537:BIU88 RS01330
gene id: 274537:BIU88_RS01330
uniprot id: A0A1D8D292
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

274537:BIU88 RS02385
gene id: 274537:BIU88_RS02385
uniprot id: A0A1D8CW33
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

274537:BIU88 RS04415
gene id: 274537:BIU88_RS04415
uniprot id: A0A1D8CX11
names: Function
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.
messages: Involved in bacteriochlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.

274537:BIU88 RS06410
gene id: 274537:BIU88_RS06410
uniprot id: A0A1D8D2L1
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS07610
gene id: 274537:BIU88_RS07610
uniprot id: A0A1D8CYM7
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

274537:BIU88 RS10540
gene id: 274537:BIU88_RS10540
uniprot id: A0A1D8D260
names: Similarity
messages: Belongs to the arsA ATPase family.

274537:BIU88 RS02905
gene id: 274537:BIU88_RS02905
uniprot id: A0A1D8D2T7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

274537:BIU88 RS03955
gene id: 274537:BIU88_RS03955
uniprot id: A0A1D8CWU0
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS10910
gene id: 274537:BIU88_RS10910
uniprot id: A0A1D8D8P3
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

274537:BIU88 RS06810
gene id: 274537:BIU88_RS06810
uniprot id: A0A1D8D6R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS00870
gene id: 274537:BIU88_RS00870
uniprot id: A0A1D8D238
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS04605
gene id: 274537:BIU88_RS04605
uniprot id: A0A1D8D060
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

274537:BIU88 RS06280
gene id: 274537:BIU88_RS06280
uniprot id: A0A1D8D066
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

274537:BIU88 RS12295
gene id: 274537:BIU88_RS12295
uniprot id: A0A1D8D5Y1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS01030
gene id: 274537:BIU88_RS01030
uniprot id: A0A1D8D257
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

274537:BIU88 RS09960
gene id: 274537:BIU88_RS09960
uniprot id: A0A1D8D3S4
names: Similarity
messages: Belongs to the DinB family.

274537:BIU88 RS10510
gene id: 274537:BIU88_RS10510
uniprot id: A0A1D8D3X9
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

274537:BIU88 RS01970
gene id: 274537:BIU88_RS01970
uniprot id: A0A1D8D587
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

274537:BIU88 RS04815
gene id: 274537:BIU88_RS04815
uniprot id: A0A1D8CX75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

274537:BIU88 RS04765
gene id: 274537:BIU88_RS04765
uniprot id: A0A1D8D087
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

274537:BIU88 RS06260
gene id: 274537:BIU88_RS06260
uniprot id: A0A1D8D3Y4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

274537:BIU88 RS04945
gene id: 274537:BIU88_RS04945
uniprot id: A0A1D8D3I7
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

274537:BIU88 RS03890
gene id: 274537:BIU88_RS03890
uniprot id: A0A1D8D6Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

274537:BIU88 RS02515
gene id: 274537:BIU88_RS02515
uniprot id: A0A1D8D118
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

274537:BIU88 RS04405
gene id: 274537:BIU88_RS04405
uniprot id: A0A1D8CX08
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

274537:BIU88 RS11895
gene id: 274537:BIU88_RS11895
uniprot id: A0A1D8D365
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

274537:BIU88 RS11240
gene id: 274537:BIU88_RS11240
uniprot id: A0A1D8D752
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

274537:BIU88 RS02535
gene id: 274537:BIU88_RS02535
uniprot id: A0A1D8D5H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS08145
gene id: 274537:BIU88_RS08145
uniprot id: A0A1D8D351
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

274537:BIU88 RS09285
gene id: 274537:BIU88_RS09285
uniprot id: A0A1D8D6A3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

274537:BIU88 RS00375
gene id: 274537:BIU88_RS00375
uniprot id: A0A1D8CXC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

274537:BIU88 RS07985
gene id: 274537:BIU88_RS07985
uniprot id: A0A1D8CYU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

274537:BIU88 RS01510
gene id: 274537:BIU88_RS01510
uniprot id: A0A1D8D2B0
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

274537:BIU88 RS00590
gene id: 274537:BIU88_RS00590
uniprot id: A0A1D8CVC1
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

274537:BIU88 RS12195
gene id: 274537:BIU88_RS12195
uniprot id: A0A1D8D0U6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

274537:BIU88 RS11575
gene id: 274537:BIU88_RS11575
uniprot id: A0A1D8D4A5
names: Similarity
messages: Belongs to the peptidase C40 family.

274537:BIU88 RS00240
gene id: 274537:BIU88_RS00240
uniprot id: A0A1D8CY44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS01335
gene id: 274537:BIU88_RS01335
uniprot id: A0A1D8D4X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

274537:BIU88 RS05565
gene id: 274537:BIU88_RS05565
uniprot id: A0A1D8CXL0
names: Similarity
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

274537:BIU88 RS04250
gene id: 274537:BIU88_RS04250
uniprot id: A0A1D8CZ56
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

274537:BIU88 RS02640
gene id: 274537:BIU88_RS02640
uniprot id: A0A1D8D2Q0
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS00600
gene id: 274537:BIU88_RS00600
uniprot id: A0A1D8D4K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

274537:BIU88 RS09310
gene id: 274537:BIU88_RS09310
uniprot id: A0A1D8D951
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

274537:BIU88 RS03790
gene id: 274537:BIU88_RS03790
uniprot id: A0A1D8CWR2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

274537:BIU88 RS03460
gene id: 274537:BIU88_RS03460
uniprot id: A0A1D8CYU2
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

274537:BIU88 RS08045
gene id: 274537:BIU88_RS08045
uniprot id: A0A1D8CYV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

274537:BIU88 RS04950
gene id: 274537:BIU88_RS04950
uniprot id: A0A1D8D641
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

274537:BIU88 RS03705
gene id: 274537:BIU88_RS03705
uniprot id: A0A1D8D320
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS06565
gene id: 274537:BIU88_RS06565
uniprot id: A0A1D8D0B5
names: Function
names: Similarity
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.

274537:BIU88 RS01440
gene id: 274537:BIU88_RS01440
uniprot id: A0A1D8D0I5
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

274537:BIU88 RS02355
gene id: 274537:BIU88_RS02355
uniprot id: A0A1D8D5E9
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

274537:BIU88 RS10705
gene id: 274537:BIU88_RS10705
uniprot id: A0A1D8D045
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS01695
gene id: 274537:BIU88_RS01695
uniprot id: A0A1D8D635
names: Similarity
messages: Belongs to the arsA ATPase family.

274537:BIU88 RS11205
gene id: 274537:BIU88_RS11205
uniprot id: A0A1D8D1U4
names: Similarity
messages: Belongs to the peptidase S66 family.

274537:BIU88 RS03835
gene id: 274537:BIU88_RS03835
uniprot id: A0A1D8D6X3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

274537:BIU88 RS00465
gene id: 274537:BIU88_RS00465
uniprot id: A0A1D8D3J3
names: Similarity
messages: Belongs to the polysaccharide synthase family.

274537:BIU88 RS02420
gene id: 274537:BIU88_RS02420
uniprot id: A0A1D8D5F8
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS05840
gene id: 274537:BIU88_RS05840
uniprot id: A0A1D8D4U1
names: Similarity
messages: Belongs to the peptidase S41A family.

274537:BIU88 RS00850
gene id: 274537:BIU88_RS00850
uniprot id: A0A1D8CYD2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS10905
gene id: 274537:BIU88_RS10905
uniprot id: A0A1D8D5K8
names: Similarity
messages: Belongs to the threonine synthase family.

274537:BIU88 RS08180
gene id: 274537:BIU88_RS08180
uniprot id: A0A1D8CYY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

274537:BIU88 RS05005
gene id: 274537:BIU88_RS05005
uniprot id: A0A1D8D647
names: Similarity
messages: Belongs to the UPF0251 family.

274537:BIU88 RS01140
gene id: 274537:BIU88_RS01140
uniprot id: A0A1D8D0D4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

274537:BIU88 RS08040
gene id: 274537:BIU88_RS08040
uniprot id: A0A1D8D8T8
names: Similarity
messages: Belongs to the archease family.

274537:BIU88 RS03685
gene id: 274537:BIU88_RS03685
uniprot id: A0A1D8CZT0
names: Similarity
messages: Belongs to the glutamine synthetase family.

274537:BIU88 RS03565
gene id: 274537:BIU88_RS03565
uniprot id: A0A1D8CWN1
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

274537:BIU88 RS12210
gene id: 274537:BIU88_RS12210
uniprot id: A0A1D8D399
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

274537:BIU88 RS02280
gene id: 274537:BIU88_RS02280
uniprot id: A0A1D8D453
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS02500
gene id: 274537:BIU88_RS02500
uniprot id: A0A1D8CW59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

274537:BIU88 RS09005
gene id: 274537:BIU88_RS09005
uniprot id: A0A1D8CZA3
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

274537:BIU88 RS09085
gene id: 274537:BIU88_RS09085
uniprot id: A0A1D8D1J0
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

274537:BIU88 RS12680
gene id: 274537:BIU88_RS12680
uniprot id: A0A1D8DA06
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

274537:BIU88 RS05220
gene id: 274537:BIU88_RS05220
uniprot id: A0A1D8D662
names: Similarity
messages: Belongs to the peptidase S41A family.

274537:BIU88 RS03690
gene id: 274537:BIU88_RS03690
uniprot id: A0A1D8D4J0
names: Similarity
messages: Belongs to the UPF0047 family.

274537:BIU88 RS06200
gene id: 274537:BIU88_RS06200
uniprot id: A0A1D8D6J2
names: Similarity
messages: Belongs to the transglycosylase Slt family.

274537:BIU88 RS04610
gene id: 274537:BIU88_RS04610
uniprot id: A0A1D8D4W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: Belongs to the bacterial reverse transcriptase family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

274537:BIU88 RS03595
gene id: 274537:BIU88_RS03595
uniprot id: A0A1D8CWN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

274537:BIU88 RS02005
gene id: 274537:BIU88_RS02005
uniprot id: A0A1D8CYZ8
names: Similarity
messages: Belongs to the HypE family.

274537:BIU88 RS10045
gene id: 274537:BIU88_RS10045
uniprot id: A0A1D8D202
names: Similarity
messages: Belongs to the ParB family.

274537:BIU88 RS05145
gene id: 274537:BIU88_RS05145
uniprot id: A0A1D8D577
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS11675
gene id: 274537:BIU88_RS11675
uniprot id: A0A1D8D4B5
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

274537:BIU88 RS07145
gene id: 274537:BIU88_RS07145
uniprot id: A0A1D8CYC7
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

274537:BIU88 RS04745
gene id: 274537:BIU88_RS04745
uniprot id: A0A1D8D7C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

274537:BIU88 RS04205
gene id: 274537:BIU88_RS04205
uniprot id: A0A1D8D4Q2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS03975
gene id: 274537:BIU88_RS03975
uniprot id: A0A1D8D4L2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

274537:BIU88 RS05255
gene id: 274537:BIU88_RS05255
uniprot id: A0A1D8D270
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates guanosine-37 in various tRNAs.

274537:BIU88 RS06345
gene id: 274537:BIU88_RS06345
uniprot id: A0A1D8D5K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

274537:BIU88 RS12465
gene id: 274537:BIU88_RS12465
uniprot id: A0A1D8D940
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

274537:BIU88 RS05440
gene id: 274537:BIU88_RS05440
uniprot id: A0A1D8CXI0
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS06190
gene id: 274537:BIU88_RS06190
uniprot id: A0A1D8CXY3
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

274537:BIU88 RS06945
gene id: 274537:BIU88_RS06945
uniprot id: A0A1D8D6T9
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS02995
gene id: 274537:BIU88_RS02995
uniprot id: A0A1D8CWE0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS03135
gene id: 274537:BIU88_RS03135
uniprot id: A0A1D8D4E5
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: This protein is a Fe-Mo-cofactor biosynthetic component.

274537:BIU88 RS07340
gene id: 274537:BIU88_RS07340
uniprot id: A0A1D8D2X0
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

274537:BIU88 RS03560
gene id: 274537:BIU88_RS03560
uniprot id: A0A1D8D6S4
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

274537:BIU88 RS07295
gene id: 274537:BIU88_RS07295
uniprot id: A0A1D8D8H8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

274537:BIU88 RS07225
gene id: 274537:BIU88_RS07225
uniprot id: A0A1D8CYE4
names: Similarity
messages: Belongs to the peptidase A31 family.

274537:BIU88 RS09435
gene id: 274537:BIU88_RS09435
uniprot id: A0A1D8CZG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

274537:BIU88 RS07280
gene id: 274537:BIU88_RS07280
uniprot id: A0A1D8CYF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

274537:BIU88 RS10645
gene id: 274537:BIU88_RS10645
uniprot id: A0A1D8D269
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

274537:BIU88 RS11260
gene id: 274537:BIU88_RS11260
uniprot id: A0A1D8D8U3
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS06555
gene id: 274537:BIU88_RS06555
uniprot id: A0A1D8D854
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS00485
gene id: 274537:BIU88_RS00485
uniprot id: A0A1D8D4J5
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

274537:BIU88 RS08365
gene id: 274537:BIU88_RS08365
uniprot id: A0A1D8D185
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

274537:BIU88 RS08030
gene id: 274537:BIU88_RS08030
uniprot id: A0A1D8D895
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

274537:BIU88 RS07020
gene id: 274537:BIU88_RS07020
uniprot id: A0A1D8D1B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS03650
gene id: 274537:BIU88_RS03650
uniprot id: A0A1D8CWN5
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

274537:BIU88 RS07895
gene id: 274537:BIU88_RS07895
uniprot id: A0A1D8CYV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

274537:BIU88 RS01840
gene id: 274537:BIU88_RS01840
uniprot id: A0A1D8D0Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

274537:BIU88 RS08155
gene id: 274537:BIU88_RS08155
uniprot id: A0A1D8D4H2
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

274537:BIU88 RS02220
gene id: 274537:BIU88_RS02220
uniprot id: A0A1D8CZ29
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS02730
gene id: 274537:BIU88_RS02730
uniprot id: A0A1D8D4A6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS00210
gene id: 274537:BIU88_RS00210
uniprot id: A0A1D8D194
names: Caution
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS11405
gene id: 274537:BIU88_RS11405
uniprot id: A0A1D8D780
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

274537:BIU88 RS02365
gene id: 274537:BIU88_RS02365
uniprot id: A0A1D8CW21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

274537:BIU88 RS10920
gene id: 274537:BIU88_RS10920
uniprot id: A0A1D8D082
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

274537:BIU88 RS01700
gene id: 274537:BIU88_RS01700
uniprot id: A0A1D8CVS0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

274537:BIU88 RS05510
gene id: 274537:BIU88_RS05510
uniprot id: A0A1D8CXK1
names: Similarity
messages: Belongs to the rubredoxin family.

274537:BIU88 RS05195
gene id: 274537:BIU88_RS05195
uniprot id: A0A1D8D0F5
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

274537:BIU88 RS01925
gene id: 274537:BIU88_RS01925
uniprot id: A0A1D8CXZ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

274537:BIU88 RS12640
gene id: 274537:BIU88_RS12640
uniprot id: A0A1D8D2V3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

274537:BIU88 RS05560
gene id: 274537:BIU88_RS05560
uniprot id: A0A1D8CZU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

274537:BIU88 RS10500
gene id: 274537:BIU88_RS10500
uniprot id: A0A1D8D2P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

274537:BIU88 RS02430
gene id: 274537:BIU88_RS02430
uniprot id: A0A1D8CW34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

274537:BIU88 RS07980
gene id: 274537:BIU88_RS07980
uniprot id: A0A1D8D8T2
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

274537:BIU88 RS03170
gene id: 274537:BIU88_RS03170
uniprot id: A0A1D8CWG8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

274537:BIU88 RS03700
gene id: 274537:BIU88_RS03700
uniprot id: A0A1D8CWP4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

274537:BIU88 RS05350
gene id: 274537:BIU88_RS05350
uniprot id: A0A1D8D0J1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

274537:BIU88 RS02110
gene id: 274537:BIU88_RS02110
uniprot id: A0A1D8CZ13
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

274537:BIU88 RS12575
gene id: 274537:BIU88_RS12575
uniprot id: A0A1D8DA00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

274537:BIU88 RS05125
gene id: 274537:BIU88_RS05125
uniprot id: A0A1D8CZM2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

274537:BIU88 RS10970
gene id: 274537:BIU88_RS10970
uniprot id: A0A1D8D094
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

274537:BIU88 RS03930
gene id: 274537:BIU88_RS03930
uniprot id: A0A1D8D1P6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

274537:BIU88 RS12130
gene id: 274537:BIU88_RS12130
uniprot id: A0A1D8D0T8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

274537:BIU88 RS06890
gene id: 274537:BIU88_RS06890
uniprot id: A0A1D8D0G8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

274537:BIU88 RS11200
gene id: 274537:BIU88_RS11200
uniprot id: A0A1D8D8T7
names: Similarity
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

274537:BIU88 RS09735
gene id: 274537:BIU88_RS09735
uniprot id: A0A1D8D3P8
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

274537:BIU88 RS11795
gene id: 274537:BIU88_RS11795
uniprot id: A0A1D8D4C4
names: Similarity
messages: Belongs to the fabD family.

274537:BIU88 RS06935
gene id: 274537:BIU88_RS06935
uniprot id: A0A1D8D3R5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

274537:BIU88 RS10860
gene id: 274537:BIU88_RS10860
uniprot id: A0A1D8D9I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 51 family.
messages: Cell membrane
messages: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.

274537:BIU88 RS02380
gene id: 274537:BIU88_RS02380
uniprot id: A0A1D8D1F5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxC family.
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

274537:BIU88 RS07390
gene id: 274537:BIU88_RS07390
uniprot id: A0A1D8D5V5
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

274537:BIU88 RS09025
gene id: 274537:BIU88_RS09025
uniprot id: A0A1D8D912
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

274537:BIU88 RS04110
gene id: 274537:BIU88_RS04110
uniprot id: A0A1D8D366
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

274537:BIU88 RS12540
gene id: 274537:BIU88_RS12540
uniprot id: A0A1D8D3E4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

274537:BIU88 RS09535
gene id: 274537:BIU88_RS09535
uniprot id: A0A1D8D816
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

274537:BIU88 RS11860
gene id: 274537:BIU88_RS11860
uniprot id: A0A1D8D0N8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

274537:BIU88 RS06985
gene id: 274537:BIU88_RS06985
uniprot id: A0A1D8CYB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

274537:BIU88 RS12110
gene id: 274537:BIU88_RS12110
uniprot id: A0A1D8D0T1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

274537:BIU88 RS03080
gene id: 274537:BIU88_RS03080
uniprot id: A0A1D8D4D9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

274537:BIU88 RS05150
gene id: 274537:BIU88_RS05150
uniprot id: A0A1D8D256
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

274537:BIU88 RS11475
gene id: 274537:BIU88_RS11475
uniprot id: A0A1D8D5Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

274537:BIU88 RS07585
gene id: 274537:BIU88_RS07585
uniprot id: A0A1D8D0S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

274537:BIU88 RS06820
gene id: 274537:BIU88_RS06820
uniprot id: A0A1D8CY86
names: Similarity
messages: Belongs to the DsrF/TusC family.

274537:BIU88 RS02340
gene id: 274537:BIU88_RS02340
uniprot id: A0A1D8CW37
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS08490
gene id: 274537:BIU88_RS08490
uniprot id: A0A1D8CZ41
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

274537:BIU88 RS08120
gene id: 274537:BIU88_RS08120
uniprot id: A0A1D8D129
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

274537:BIU88 RS10320
gene id: 274537:BIU88_RS10320
uniprot id: A0A1D8D1T3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

274537:BIU88 RS06225
gene id: 274537:BIU88_RS06225
uniprot id: A0A1D8D0Y8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

274537:BIU88 RS07735
gene id: 274537:BIU88_RS07735
uniprot id: A0A1D8D768
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

274537:BIU88 RS12185
gene id: 274537:BIU88_RS12185
uniprot id: A0A1D8D905
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

274537:BIU88 RS05860
gene id: 274537:BIU88_RS05860
uniprot id: A0A1D8D5E4
names: Similarity
messages: Belongs to the LacAB/RpiB family.

274537:BIU88 RS12435
gene id: 274537:BIU88_RS12435
uniprot id: A0A1D8D3C8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

274537:BIU88 RS08415
gene id: 274537:BIU88_RS08415
uniprot id: A0A1D8D8W9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

274537:BIU88 RS06155
gene id: 274537:BIU88_RS06155
uniprot id: A0A1D8D7Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

274537:BIU88 RS11870
gene id: 274537:BIU88_RS11870
uniprot id: A0A1D8D8Y5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

274537:BIU88 RS02230
gene id: 274537:BIU88_RS02230
uniprot id: A0A1D8D0V9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

274537:BIU88 RS06975
gene id: 274537:BIU88_RS06975
uniprot id: A0A1D8D5S0
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

274537:BIU88 RS06825
gene id: 274537:BIU88_RS06825
uniprot id: A0A1D8D0F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrE/TusD family.
messages: Cytoplasm

274537:BIU88 RS01910
gene id: 274537:BIU88_RS01910
uniprot id: A0A1D8D583
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

274537:BIU88 RS03030
gene id: 274537:BIU88_RS03030
uniprot id: A0A1D8D2U8
names: Similarity
messages: Belongs to the XFP family.

274537:BIU88 RS00095
gene id: 274537:BIU88_RS00095
uniprot id: A0A1D8D4G6
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS12150
gene id: 274537:BIU88_RS12150
uniprot id: A0A1D8D0S6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

274537:BIU88 RS03220
gene id: 274537:BIU88_RS03220
uniprot id: A0A1D8D6M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

274537:BIU88 RS00540
gene id: 274537:BIU88_RS00540
uniprot id: A0A1D8D1Y6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

274537:BIU88 RS03330
gene id: 274537:BIU88_RS03330
uniprot id: A0A1D8D1H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

274537:BIU88 RS00840
gene id: 274537:BIU88_RS00840
uniprot id: A0A1D8CVF0
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

274537:BIU88 RS10000
gene id: 274537:BIU88_RS10000
uniprot id: A0A1D8CZR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MenH family.
messages: Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
messages: Monomer.

274537:BIU88 RS11835
gene id: 274537:BIU88_RS11835
uniprot id: A0A1D8D2K5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ChlB/BchB/BchZ family.
messages: Chlorophyllide reductase is composed of three subunits; BchX, BchY and BchZ. Forms a heterodimer of one BchY and one BchZ subunit.
messages: Converts chlorophylls (Chl) into bacteriochlorophylls (BChl) by reducing ring B of the tetrapyrrole.

274537:BIU88 RS09945
gene id: 274537:BIU88_RS09945
uniprot id: A0A1D8CZQ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

274537:BIU88 RS02960
gene id: 274537:BIU88_RS02960
uniprot id: A0A1D8CWD3
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

274537:BIU88 RS09655
gene id: 274537:BIU88_RS09655
uniprot id: A0A1D8CZK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

274537:BIU88 RS07905
gene id: 274537:BIU88_RS07905
uniprot id: A0A1D8DAC4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS07825
gene id: 274537:BIU88_RS07825
uniprot id: A0A1D8D5Z1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

274537:BIU88 RS12445
gene id: 274537:BIU88_RS12445
uniprot id: A0A1D8D4H9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

274537:BIU88 RS01305
gene id: 274537:BIU88_RS01305
uniprot id: A0A1D8D1C0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

274537:BIU88 RS02160
gene id: 274537:BIU88_RS02160
uniprot id: A0A1D8CY34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BChl C/E-binding protein family.
messages: Component of the photosynthetic apparatus.
messages: chlorosome envelope

274537:BIU88 RS07125
gene id: 274537:BIU88_RS07125
uniprot id: A0A1D8D8F1
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

274537:BIU88 RS08865
gene id: 274537:BIU88_RS08865
uniprot id: A0A1D8D1F3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

274537:BIU88 RS06320
gene id: 274537:BIU88_RS06320
uniprot id: A0A1D8D819
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

274537:BIU88 RS04500
gene id: 274537:BIU88_RS04500
uniprot id: A0A1D8D4U4
names: Similarity
messages: Belongs to the YoeB family.

274537:BIU88 RS09800
gene id: 274537:BIU88_RS09800
uniprot id: A0A1D8CZN3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

274537:BIU88 RS06845
gene id: 274537:BIU88_RS06845
uniprot id: A0A1D8D2R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

274537:BIU88 RS12015
gene id: 274537:BIU88_RS12015
uniprot id: A0A1D8D9X1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

274537:BIU88 RS07460
gene id: 274537:BIU88_RS07460
uniprot id: A0A1D8CYL7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

274537:BIU88 RS03230
gene id: 274537:BIU88_RS03230
uniprot id: A0A1D8CYM6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

274537:BIU88 RS01080
gene id: 274537:BIU88_RS01080
uniprot id: A0A1D8D0C0
names: Similarity
messages: Belongs to the ribF family.

274537:BIU88 RS11305
gene id: 274537:BIU88_RS11305
uniprot id: A0A1D8D478
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

274537:BIU88 RS00410
gene id: 274537:BIU88_RS00410
uniprot id: A0A1D8D4L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

274537:BIU88 RS03865
gene id: 274537:BIU88_RS03865
uniprot id: A0A1D8D4K3
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

274537:BIU88 RS12565
gene id: 274537:BIU88_RS12565
uniprot id: A0A1D8D603
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

274537:BIU88 RS05245
gene id: 274537:BIU88_RS05245
uniprot id: A0A1D8D0H1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

274537:BIU88 RS03490
gene id: 274537:BIU88_RS03490
uniprot id: A0A1D8CWL1
names: Similarity
messages: Belongs to the PucC family.

274537:BIU88 RS06245
gene id: 274537:BIU88_RS06245
uniprot id: A0A1D8D2J2
names: Similarity
messages: Belongs to the CFA/CMAS family.

274537:BIU88 RS04210
gene id: 274537:BIU88_RS04210
uniprot id: A0A1D8D1T7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates zinc uptake. May also transport other divalent cations.
messages: Membrane

274537:BIU88 RS02525
gene id: 274537:BIU88_RS02525
uniprot id: A0A1D8D2N3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

274537:BIU88 RS07395
gene id: 274537:BIU88_RS07395
uniprot id: A0A1D8D2X6
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

274537:BIU88 RS05090
gene id: 274537:BIU88_RS05090
uniprot id: A0A1D8D567
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS09600
gene id: 274537:BIU88_RS09600
uniprot id: A0A1D8CZJ8
names: Similarity
messages: Belongs to the TrbE/VirB4 family.

274537:BIU88 RS01355
gene id: 274537:BIU88_RS01355
uniprot id: A0A1D8CXS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

274537:BIU88 RS08940
gene id: 274537:BIU88_RS08940
uniprot id: A0A1D8D681
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

274537:BIU88 RS09805
gene id: 274537:BIU88_RS09805
uniprot id: A0A1D8D547
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

274537:BIU88 RS07150
gene id: 274537:BIU88_RS07150
uniprot id: A0A1D8D1E3
names: Similarity
messages: Belongs to the universal stress protein A family.

274537:BIU88 RS01660
gene id: 274537:BIU88_RS01660
uniprot id: A0A1D8CYT8
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

274537:BIU88 RS05180
gene id: 274537:BIU88_RS05180
uniprot id: A0A1D8CZM9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

274537:BIU88 RS00065
gene id: 274537:BIU88_RS00065
uniprot id: A0A1D8CV40
names: Similarity
messages: Belongs to the universal stress protein A family.

274537:BIU88 RS11810
gene id: 274537:BIU88_RS11810
uniprot id: A0A1D8D5T6
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

274537:BIU88 RS12420
gene id: 274537:BIU88_RS12420
uniprot id: A0A1D8D2S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

274537:BIU88 RS12650
gene id: 274537:BIU88_RS12650
uniprot id: A0A1D8D3G4
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS09425
gene id: 274537:BIU88_RS09425
uniprot id: A0A1D8D801
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

274537:BIU88 RS00630
gene id: 274537:BIU88_RS00630
uniprot id: A0A1D8D3M0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

274537:BIU88 RS12085
gene id: 274537:BIU88_RS12085
uniprot id: A0A1D8D2M8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

274537:BIU88 RS11930
gene id: 274537:BIU88_RS11930
uniprot id: A0A1D8D9W8
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

274537:BIU88 RS00285
gene id: 274537:BIU88_RS00285
uniprot id: A0A1D8CV75
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS06950
gene id: 274537:BIU88_RS06950
uniprot id: A0A1D8D8B8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

274537:BIU88 RS02045
gene id: 274537:BIU88_RS02045
uniprot id: A0A1D8CVW6
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

274537:BIU88 RS02645
gene id: 274537:BIU88_RS02645
uniprot id: A0A1D8D5J6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS11630
gene id: 274537:BIU88_RS11630
uniprot id: A0A1D8D0K3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS05670
gene id: 274537:BIU88_RS05670
uniprot id: A0A1D8CXM1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

274537:BIU88 RS10175
gene id: 274537:BIU88_RS10175
uniprot id: A0A1D8D3U5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

274537:BIU88 RS11785
gene id: 274537:BIU88_RS11785
uniprot id: A0A1D8D7E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

274537:BIU88 RS12645
gene id: 274537:BIU88_RS12645
uniprot id: A0A1D8D167
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS10505
gene id: 274537:BIU88_RS10505
uniprot id: A0A1D8D6T1
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

274537:BIU88 RS11530
gene id: 274537:BIU88_RS11530
uniprot id: A0A1D8D1U5
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

274537:BIU88 RS10885
gene id: 274537:BIU88_RS10885
uniprot id: A0A1D8D2U7
names: Similarity
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

274537:BIU88 RS00500
gene id: 274537:BIU88_RS00500
uniprot id: A0A1D8CVA2
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

274537:BIU88 RS10040
gene id: 274537:BIU88_RS10040
uniprot id: A0A1D8CZT4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

274537:BIU88 RS04625
gene id: 274537:BIU88_RS04625
uniprot id: A0A1D8D3D0
names: Similarity
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.

274537:BIU88 RS04595
gene id: 274537:BIU88_RS04595
uniprot id: A0A1D8CZC5
names: Similarity
messages: Belongs to the UPF0047 family.

274537:BIU88 RS00135
gene id: 274537:BIU88_RS00135
uniprot id: A0A1D8CV63
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

274537:BIU88 RS05110
gene id: 274537:BIU88_RS05110
uniprot id: A0A1D8D655
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

274537:BIU88 RS10250
gene id: 274537:BIU88_RS10250
uniprot id: A0A1D8CZW5
names: Similarity
messages: Belongs to the universal stress protein A family.

274537:BIU88 RS00005
gene id: 274537:BIU88_RS00005
uniprot id: A0A1D8CV25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

274537:BIU88 RS07155
gene id: 274537:BIU88_RS07155
uniprot id: A0A1D8D5T5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

274537:BIU88 RS01600
gene id: 274537:BIU88_RS01600
uniprot id: A0A1D8CYS2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

274537:BIU88 RS00200
gene id: 274537:BIU88_RS00200
uniprot id: A0A1D8D1U2
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS06310
gene id: 274537:BIU88_RS06310
uniprot id: A0A1D8D3Y8
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS05055
gene id: 274537:BIU88_RS05055
uniprot id: A0A1D8D649
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

274537:BIU88 RS11955
gene id: 274537:BIU88_RS11955
uniprot id: A0A1D8D372
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS04690
gene id: 274537:BIU88_RS04690
uniprot id: A0A1D8D7B6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

274537:BIU88 RS02425
gene id: 274537:BIU88_RS02425
uniprot id: A0A1D8D690
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS12795
gene id: 274537:BIU88_RS12795
uniprot id: A0A1D8D198
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

274537:BIU88 RS00390
gene id: 274537:BIU88_RS00390
uniprot id: A0A1D8D7W5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

274537:BIU88 RS12180
gene id: 274537:BIU88_RS12180
uniprot id: A0A1D8D5W9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

274537:BIU88 RS11755
gene id: 274537:BIU88_RS11755
uniprot id: A0A1D8D2J8
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

274537:BIU88 RS02620
gene id: 274537:BIU88_RS02620
uniprot id: A0A1D8CZB0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

274537:BIU88 RS00245
gene id: 274537:BIU88_RS00245
uniprot id: A0A1D8D3G6
names: Similarity
messages: Belongs to the P(II) protein family.

274537:BIU88 RS01255
gene id: 274537:BIU88_RS01255
uniprot id: A0A1D8D0F4
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS11505
gene id: 274537:BIU88_RS11505
uniprot id: A0A1D8D318
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

274537:BIU88 RS10800
gene id: 274537:BIU88_RS10800
uniprot id: A0A1D8D9H4
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

274537:BIU88 RS05450
gene id: 274537:BIU88_RS05450
uniprot id: A0A1D8CXJ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS09165
gene id: 274537:BIU88_RS09165
uniprot id: A0A1D8CZE2
names: Similarity
messages: Belongs to the universal stress protein A family.

274537:BIU88 RS12105
gene id: 274537:BIU88_RS12105
uniprot id: A0A1D8D4E8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

274537:BIU88 RS01215
gene id: 274537:BIU88_RS01215
uniprot id: A0A1D8D4W1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

274537:BIU88 RS12065
gene id: 274537:BIU88_RS12065
uniprot id: A0A1D8D5V6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

274537:BIU88 RS10180
gene id: 274537:BIU88_RS10180
uniprot id: A0A1D8CZU6
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

274537:BIU88 RS06560
gene id: 274537:BIU88_RS06560
uniprot id: A0A1D8CY40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

274537:BIU88 RS10690
gene id: 274537:BIU88_RS10690
uniprot id: A0A1D8D9F6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

274537:BIU88 RS01365
gene id: 274537:BIU88_RS01365
uniprot id: A0A1D8CYL8
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

274537:BIU88 RS01110
gene id: 274537:BIU88_RS01110
uniprot id: A0A1D8CVI6
names: Subcellular Location Annotation
messages: Cytoplasm

274537:BIU88 RS05505
gene id: 274537:BIU88_RS05505
uniprot id: A0A1D8CZU1
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

274537:BIU88 RS05345
gene id: 274537:BIU88_RS05345
uniprot id: A0A1D8CXH2
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

274537:BIU88 RS06430
gene id: 274537:BIU88_RS06430
uniprot id: A0A1D8D3Z7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS10325
gene id: 274537:BIU88_RS10325
uniprot id: A0A1D8CZY1
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

274537:BIU88 RS11905
gene id: 274537:BIU88_RS11905
uniprot id: A0A1D8D4D4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

274537:BIU88 RS09850
gene id: 274537:BIU88_RS09850
uniprot id: A0A1D8D3Q9
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

274537:BIU88 RS10925
gene id: 274537:BIU88_RS10925
uniprot id: A0A1D8D2A5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS08175
gene id: 274537:BIU88_RS08175
uniprot id: A0A1D8D142
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

274537:BIU88 RS05275
gene id: 274537:BIU88_RS05275
uniprot id: A0A1D8D7L7
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS10760
gene id: 274537:BIU88_RS10760
uniprot id: A0A1D8D3A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

274537:BIU88 RS12045
gene id: 274537:BIU88_RS12045
uniprot id: A0A1D8D1V8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

274537:BIU88 RS03300
gene id: 274537:BIU88_RS03300
uniprot id: A0A1D8D1F2
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS11295
gene id: 274537:BIU88_RS11295
uniprot id: A0A1D8D3A8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

274537:BIU88 RS02560
gene id: 274537:BIU88_RS02560
uniprot id: A0A1D8CW66
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

274537:BIU88 RS01450
gene id: 274537:BIU88_RS01450
uniprot id: A0A1D8D2A3
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

274537:BIU88 RS03160
gene id: 274537:BIU88_RS03160
uniprot id: A0A1D8D9A0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

274537:BIU88 RS04895
gene id: 274537:BIU88_RS04895
uniprot id: A0A1D8D638
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

274537:BIU88 RS04255
gene id: 274537:BIU88_RS04255
uniprot id: A0A1D8CWY1
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

274537:BIU88 RS08435
gene id: 274537:BIU88_RS08435
uniprot id: A0A1D8D1Z6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

274537:BIU88 RS07945
gene id: 274537:BIU88_RS07945
uniprot id: A0A1D8D601
names: Similarity
messages: Belongs to the UPF0758 family.

274537:BIU88 RS04045
gene id: 274537:BIU88_RS04045
uniprot id: A0A1D8CWV2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

274537:BIU88 RS12765
gene id: 274537:BIU88_RS12765
uniprot id: A0A1D8D7U5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

274537:BIU88 RS00335
gene id: 274537:BIU88_RS00335
uniprot id: A0A1D8D1W2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

274537:BIU88 RS00365
gene id: 274537:BIU88_RS00365
uniprot id: A0A1D8D5S2
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

274537:BIU88 RS10310
gene id: 274537:BIU88_RS10310
uniprot id: A0A1D8CZX5
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

274537:BIU88 RS03305
gene id: 274537:BIU88_RS03305
uniprot id: A0A1D8CWI1
names: Similarity
messages: Belongs to the Fur family.

274537:BIU88 RS02760
gene id: 274537:BIU88_RS02760
uniprot id: A0A1D8D5K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

274537:BIU88 RS03085
gene id: 274537:BIU88_RS03085
uniprot id: A0A1D8D1B8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

274537:BIU88 RS07230
gene id: 274537:BIU88_RS07230
uniprot id: A0A1D8D494
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

274537:BIU88 RS06165
gene id: 274537:BIU88_RS06165
uniprot id: A0A1D8D048
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS00190
gene id: 274537:BIU88_RS00190
uniprot id: A0A1D8CZX8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

274537:BIU88 RS10495
gene id: 274537:BIU88_RS10495
uniprot id: A0A1D8D009
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

274537:BIU88 RS00060
gene id: 274537:BIU88_RS00060
uniprot id: A0A1D8CX67
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

274537:BIU88 RS11050
gene id: 274537:BIU88_RS11050
uniprot id: A0A1D8D1U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

274537:BIU88 RS01085
gene id: 274537:BIU88_RS01085
uniprot id: A0A1D8CVI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

274537:BIU88 RS08150
gene id: 274537:BIU88_RS08150
uniprot id: A0A1D8CYY6
names: Similarity
messages: Belongs to the GroES chaperonin family.

274537:BIU88 RS11010
gene id: 274537:BIU88_RS11010
uniprot id: N0DKX5
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cells lacking this gene are unable to produce bacteriochlorophyll e (BChl e), accumulate bacteriochlorophyll c (BChl c) and are green in color instead of the characteristic brownish color (PubMed:23560066, PubMed:27994052). The mutant also has a novel homolog containing a triple 8-methylated neopentyl substituent at the 8-position (PubMed:24496988).
messages: Involved in the biosynthesis of bacteriochlorophyll e (BChl e). Catalyzes two consecutive hydroxylation reactions of the C-7 methyl group of bacteriochlorophyllide c (BChlide c) to form a geminal diol intermediate that spontaneously dehydrates to produce the formyl group of bacteriochlorophyllide e (BChlide e) (PubMed:23560066, PubMed:27994052). Also able to catalyze the same reaction for bacteriochlorophyllide d (BChlide d) to give rise to bacteriochlorophyllide f (BChlide f) (PubMed:27994052).

274537:BIU88 RS05135
gene id: 274537:BIU88_RS05135
uniprot id: A0A1D8CXD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

274537:BIU88 RS11195
gene id: 274537:BIU88_RS11195
uniprot id: A0A1D8D5N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

274537:BIU88 RS10720
gene id: 274537:BIU88_RS10720
uniprot id: A0A1D8D3Z8
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

274537:BIU88 RS01320
gene id: 274537:BIU88_RS01320
uniprot id: A0A1D8D0G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

274537:BIU88 RS09020
gene id: 274537:BIU88_RS09020
uniprot id: A0A1D8D7V1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

274537:BIU88 RS02890
gene id: 274537:BIU88_RS02890
uniprot id: A0A1D8D4C3
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS03120
gene id: 274537:BIU88_RS03120
uniprot id: A0A1D8CYJ9
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

274537:BIU88 RS07560
gene id: 274537:BIU88_RS07560
uniprot id: A0A1D8CYM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

274537:BIU88 RS03785
gene id: 274537:BIU88_RS03785
uniprot id: A0A1D8CYZ1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS02755
gene id: 274537:BIU88_RS02755
uniprot id: A0A1D8D2R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

274537:BIU88 RS01145
gene id: 274537:BIU88_RS01145
uniprot id: A0A1D8CVJ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS07385
gene id: 274537:BIU88_RS07385
uniprot id: A0A1D8D1M7
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS06355
gene id: 274537:BIU88_RS06355
uniprot id: A0A1D8D2K4
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

274537:BIU88 RS01985
gene id: 274537:BIU88_RS01985
uniprot id: A0A1D8CVV7
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

274537:BIU88 RS06545
gene id: 274537:BIU88_RS06545
uniprot id: A0A1D8D410
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

274537:BIU88 RS05465
gene id: 274537:BIU88_RS05465
uniprot id: A0A1D8D5B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

274537:BIU88 RS09910
gene id: 274537:BIU88_RS09910
uniprot id: A0A1D8CZQ3
names: Similarity
messages: Belongs to the UPF0235 family.

274537:BIU88 RS08455
gene id: 274537:BIU88_RS08455
uniprot id: A0A1D8D4K1
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS11160
gene id: 274537:BIU88_RS11160
uniprot id: A0A1D8D0C2
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS03005
gene id: 274537:BIU88_RS03005
uniprot id: A0A1D8D4D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

274537:BIU88 RS12140
gene id: 274537:BIU88_RS12140
uniprot id: A0A1D8D2N5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

274537:BIU88 RS05920
gene id: 274537:BIU88_RS05920
uniprot id: A0A1D8D2F6
names: Similarity
messages: Belongs to the BMP lipoprotein family.

274537:BIU88 RS01170
gene id: 274537:BIU88_RS01170
uniprot id: A0A1D8CXQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

274537:BIU88 RS03860
gene id: 274537:BIU88_RS03860
uniprot id: A0A1D8CZV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

274537:BIU88 RS06115
gene id: 274537:BIU88_RS06115
uniprot id: A0A1D8D0X4
names: Subcellular Location Annotation
messages: chloroplast

274537:BIU88 RS02930
gene id: 274537:BIU88_RS02930
uniprot id: A0A1D8CYH3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

274537:BIU88 RS01895
gene id: 274537:BIU88_RS01895
uniprot id: A0A1D8D0R0
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

274537:BIU88 RS08495
gene id: 274537:BIU88_RS08495
uniprot id: A0A1D8D206
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

274537:BIU88 RS07365
gene id: 274537:BIU88_RS07365
uniprot id: A0A1D8CYG7
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

274537:BIU88 RS11495
gene id: 274537:BIU88_RS11495
uniprot id: A0A1D8D2G6
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

274537:BIU88 RS04730
gene id: 274537:BIU88_RS04730
uniprot id: A0A1D8D1J3
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

274537:BIU88 RS01635
gene id: 274537:BIU88_RS01635
uniprot id: A0A1D8D518
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

274537:BIU88 RS02530
gene id: 274537:BIU88_RS02530
uniprot id: A0A1D8D4Q1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

274537:BIU88 RS02105
gene id: 274537:BIU88_RS02105
uniprot id: A0A1D8CVY1
names: Similarity
messages: Belongs to the RuBisCO large chain family.

274537:BIU88 RS01015
gene id: 274537:BIU88_RS01015
uniprot id: A0A1D8D3R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

274537:BIU88 RS08185
gene id: 274537:BIU88_RS08185
uniprot id: A0A1D8D1V3
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Belongs to the pyruvoyl-dependent arginine decarboxylase family.
messages: Binds 1 pyruvoyl group covalently per subunit.

274537:BIU88 RS03155
gene id: 274537:BIU88_RS03155
uniprot id: A0A1D8D5N9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

274537:BIU88 RS09755
gene id: 274537:BIU88_RS09755
uniprot id: A0A1D8D984
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

274537:BIU88 RS02540
gene id: 274537:BIU88_RS02540
uniprot id: A0A1D8D6A0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

274537:BIU88 RS01205
gene id: 274537:BIU88_RS01205
uniprot id: A0A1D8CVK7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

274537:BIU88 RS00765
gene id: 274537:BIU88_RS00765
uniprot id: A0A1D8D5V8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

274537:BIU88 RS00370
gene id: 274537:BIU88_RS00370
uniprot id: A0A1D8CV86
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

274537:BIU88 RS07920
gene id: 274537:BIU88_RS07920
uniprot id: A0A1D8CYT5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS11745
gene id: 274537:BIU88_RS11745
uniprot id: A0A1D8D9V9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

274537:BIU88 RS01930
gene id: 274537:BIU88_RS01930
uniprot id: A0A1D8D3L6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS02370
gene id: 274537:BIU88_RS02370
uniprot id: A0A1D8CY71
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

274537:BIU88 RS03600
gene id: 274537:BIU88_RS03600
uniprot id: A0A1D8D306
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

274537:BIU88 RS01605
gene id: 274537:BIU88_RS01605
uniprot id: A0A1D8D3X2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

274537:BIU88 RS05240
gene id: 274537:BIU88_RS05240
uniprot id: A0A1D8CXF1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

274537:BIU88 RS12480
gene id: 274537:BIU88_RS12480
uniprot id: A0A1D8D2T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

274537:BIU88 RS00660
gene id: 274537:BIU88_RS00660
uniprot id: A0A1D8CVC8
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

274537:BIU88 RS12060
gene id: 274537:BIU88_RS12060
uniprot id: A0A1D8D0R9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

274537:BIU88 RS01325
gene id: 274537:BIU88_RS01325
uniprot id: A0A1D8CVM2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

274537:BIU88 RS03900
gene id: 274537:BIU88_RS03900
uniprot id: A0A1D8CZ09
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

274537:BIU88 RS04890
gene id: 274537:BIU88_RS04890
uniprot id: A0A1D8D3H7
names: Similarity
messages: Belongs to the Nudix hydrolase family.

274537:BIU88 RS09750
gene id: 274537:BIU88_RS09750
uniprot id: A0A1D8D846
names: Similarity
messages: Belongs to the glutamate synthase family.

274537:BIU88 RS12275
gene id: 274537:BIU88_RS12275
uniprot id: A0A1D8D7N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

274537:BIU88 RS00585
gene id: 274537:BIU88_RS00585
uniprot id: A0A1D8D036
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

274537:BIU88 RS01435
gene id: 274537:BIU88_RS01435
uniprot id: A0A1D8D3V9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

274537:BIU88 RS06060
gene id: 274537:BIU88_RS06060
uniprot id: A0A1D8D0W2
names: Similarity
messages: Belongs to the YjdM family.

274537:BIU88 RS06505
gene id: 274537:BIU88_RS06505
uniprot id: A0A1D8CY27
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

274537:BIU88 RS00215
gene id: 274537:BIU88_RS00215
uniprot id: A0A1D8D4H6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

274537:BIU88 RS02450
gene id: 274537:BIU88_RS02450
uniprot id: A0A1D8CZ73
names: Similarity
messages: Belongs to the peptidase S49 family.

274537:BIU88 RS03575
gene id: 274537:BIU88_RS03575
uniprot id: A0A1D8CWM5
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

274537:BIU88 RS11730
gene id: 274537:BIU88_RS11730
uniprot id: A0A1D8D0L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS01775
gene id: 274537:BIU88_RS01775
uniprot id: A0A1D8D3Y6
names: Similarity
messages: Belongs to the RecJ family.

274537:BIU88 RS03075
gene id: 274537:BIU88_RS03075
uniprot id: A0A1D8D1G5
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

274537:BIU88 RS03885
gene id: 274537:BIU88_RS03885
uniprot id: A0A1D8D5V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

274537:BIU88 RS08210
gene id: 274537:BIU88_RS08210
uniprot id: A0A1D8D7E4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS09035
gene id: 274537:BIU88_RS09035
uniprot id: A0A1D8D1H7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

274537:BIU88 RS01890
gene id: 274537:BIU88_RS01890
uniprot id: A0A1D8D401
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

274537:BIU88 RS03525
gene id: 274537:BIU88_RS03525
uniprot id: A0A1D8CZQ1
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

274537:BIU88 RS01990
gene id: 274537:BIU88_RS01990
uniprot id: A0A1D8CY08
names: Similarity
messages: Belongs to the HupF/HypC family.

274537:BIU88 RS03580
gene id: 274537:BIU88_RS03580
uniprot id: A0A1D8CZR0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

274537:BIU88 RS05625
gene id: 274537:BIU88_RS05625
uniprot id: A0A1D8CXM0
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS00605
gene id: 274537:BIU88_RS00605
uniprot id: A0A1D8D5U4
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

274537:BIU88 RS02900
gene id: 274537:BIU88_RS02900
uniprot id: A0A1D8CWC7
names: Similarity
messages: Belongs to the BshC family.

274537:BIU88 RS10530
gene id: 274537:BIU88_RS10530
uniprot id: A0A1D8D9D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BChl C/E-binding protein family.
messages: Component of the photosynthetic apparatus.
messages: chlorosome envelope

274537:BIU88 RS03425
gene id: 274537:BIU88_RS03425
uniprot id: A0A1D8D4G8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

274537:BIU88 RS07245
gene id: 274537:BIU88_RS07245
uniprot id: A0A1D8CYE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

274537:BIU88 RS05800
gene id: 274537:BIU88_RS05800
uniprot id: A0A1D8D0S1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

274537:BIU88 RS00280
gene id: 274537:BIU88_RS00280
uniprot id: A0A1D8CXA7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

274537:BIU88 RS11100
gene id: 274537:BIU88_RS11100
uniprot id: A0A1D8D2C9
names: Similarity
messages: Belongs to the arsA ATPase family.

274537:BIU88 RS12070
gene id: 274537:BIU88_RS12070
uniprot id: A0A1D8D8Z7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

274537:BIU88 RS04505
gene id: 274537:BIU88_RS04505
uniprot id: A0A1D8D1X6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

274537:BIU88 RS12300
gene id: 274537:BIU88_RS12300
uniprot id: A0A1D8D913
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

274537:BIU88 RS09500
gene id: 274537:BIU88_RS09500
uniprot id: A0A1D8CZJ2
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

274537:BIU88 RS02335
gene id: 274537:BIU88_RS02335
uniprot id: A0A1D8D0X7
names: Similarity
messages: Belongs to the TrpC family.

274537:BIU88 RS05630
gene id: 274537:BIU88_RS05630
uniprot id: A0A1D8D0P0
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS11115
gene id: 274537:BIU88_RS11115
uniprot id: A0A1D8D731
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell.

274537:BIU88 RS01070
gene id: 274537:BIU88_RS01070
uniprot id: A0A1D8D3S0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

274537:BIU88 RS10550
gene id: 274537:BIU88_RS10550
uniprot id: A0A1D8D2Q3
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS00935
gene id: 274537:BIU88_RS00935
uniprot id: A0A1D8CVG3
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

274537:BIU88 RS07215
gene id: 274537:BIU88_RS07215
uniprot id: A0A1D8D675
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

274537:BIU88 RS04805
gene id: 274537:BIU88_RS04805
uniprot id: A0A1D8CX70
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS09775
gene id: 274537:BIU88_RS09775
uniprot id: A0A1D8D1S7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

274537:BIU88 RS10425
gene id: 274537:BIU88_RS10425
uniprot id: A0A1D8CZZ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

274537:BIU88 RS12725
gene id: 274537:BIU88_RS12725
uniprot id: A0A1D8D160
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS04420
gene id: 274537:BIU88_RS04420
uniprot id: A0A1D8D035
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

274537:BIU88 RS08230
gene id: 274537:BIU88_RS08230
uniprot id: A0A1D8D8V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

274537:BIU88 RS03415
gene id: 274537:BIU88_RS03415
uniprot id: A0A1D8CZN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS11340
gene id: 274537:BIU88_RS11340
uniprot id: A0A1D8D0F1
names: Similarity
messages: Belongs to the UPF0102 family.

274537:BIU88 RS12320
gene id: 274537:BIU88_RS12320
uniprot id: A0A1D8D102
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

274537:BIU88 RS00470
gene id: 274537:BIU88_RS00470
uniprot id: A0A1D8D015
names: Similarity
messages: Belongs to the archaeal-type GPI family.

274537:BIU88 RS02805
gene id: 274537:BIU88_RS02805
uniprot id: A0A1D8D2S5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

274537:BIU88 RS04240
gene id: 274537:BIU88_RS04240
uniprot id: A0A1D8D745
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

274537:BIU88 RS12100
gene id: 274537:BIU88_RS12100
uniprot id: A0A1D8D7K3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

274537:BIU88 RS01165
gene id: 274537:BIU88_RS01165
uniprot id: A0A1D8CVJ5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

274537:BIU88 RS09050
gene id: 274537:BIU88_RS09050
uniprot id: A0A1D8D688
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS04100
gene id: 274537:BIU88_RS04100
uniprot id: A0A1D8D1R9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

274537:BIU88 RS10230
gene id: 274537:BIU88_RS10230
uniprot id: A0A1D8CZV6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS08735
gene id: 274537:BIU88_RS08735
uniprot id: A0A1D8D7N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS02150
gene id: 274537:BIU88_RS02150
uniprot id: A0A1D8D668
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS10935
gene id: 274537:BIU88_RS10935
uniprot id: A0A1D8D2V5
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

274537:BIU88 RS02055
gene id: 274537:BIU88_RS02055
uniprot id: A0A1D8CVX3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

274537:BIU88 RS06220
gene id: 274537:BIU88_RS06220
uniprot id: A0A1D8CXY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

274537:BIU88 RS02725
gene id: 274537:BIU88_RS02725
uniprot id: A0A1D8CZD9
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

274537:BIU88 RS06170
gene id: 274537:BIU88_RS06170
uniprot id: A0A1D8CXX0
names: Similarity
messages: Belongs to the P(II) protein family.

274537:BIU88 RS10055
gene id: 274537:BIU88_RS10055
uniprot id: A0A1D8D2J5
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

274537:BIU88 RS08725
gene id: 274537:BIU88_RS08725
uniprot id: A0A1D8CZ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS10520
gene id: 274537:BIU88_RS10520
uniprot id: A0A1D8D5G8
names: Similarity
messages: Belongs to the arsA ATPase family.

274537:BIU88 RS09255
gene id: 274537:BIU88_RS09255
uniprot id: A0A1D8D7X2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

274537:BIU88 RS11655
gene id: 274537:BIU88_RS11655
uniprot id: A0A1D8D2I5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.
messages: Homodimer.
messages: Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.

274537:BIU88 RS00105
gene id: 274537:BIU88_RS00105
uniprot id: A0A1D8CV46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS06405
gene id: 274537:BIU88_RS06405
uniprot id: A0A1D8D5L3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

274537:BIU88 RS07990
gene id: 274537:BIU88_RS07990
uniprot id: A0A1D8D116
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

274537:BIU88 RS10025
gene id: 274537:BIU88_RS10025
uniprot id: A0A1D8D573
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

274537:BIU88 RS08945
gene id: 274537:BIU88_RS08945
uniprot id: A0A1D8D3E5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

274537:BIU88 RS01445
gene id: 274537:BIU88_RS01445
uniprot id: A0A1D8CVN9
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

274537:BIU88 RS11560
gene id: 274537:BIU88_RS11560
uniprot id: A0A1D8D0I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

274537:BIU88 RS10470
gene id: 274537:BIU88_RS10470
uniprot id: A0A1D8D8H7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS11805
gene id: 274537:BIU88_RS11805
uniprot id: A0A1D8D0M9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

274537:BIU88 RS11790
gene id: 274537:BIU88_RS11790
uniprot id: A0A1D8D558
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

274537:BIU88 RS08290
gene id: 274537:BIU88_RS08290
uniprot id: A0A1D8CYZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

274537:BIU88 RS02605
gene id: 274537:BIU88_RS02605
uniprot id: A0A1D8CW65
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

274537:BIU88 RS05520
gene id: 274537:BIU88_RS05520
uniprot id: A0A1D8D5C1
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

274537:BIU88 RS01975
gene id: 274537:BIU88_RS01975
uniprot id: A0A1D8D656
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

274537:BIU88 RS11345
gene id: 274537:BIU88_RS11345
uniprot id: A0A1D8D2Z8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

274537:BIU88 RS02685
gene id: 274537:BIU88_RS02685
uniprot id: A0A1D8CW86
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS01715
gene id: 274537:BIU88_RS01715
uniprot id: A0A1D8CYU6
names: Similarity
messages: Belongs to the pirin family.

274537:BIU88 RS04030
gene id: 274537:BIU88_RS04030
uniprot id: A0A1D8CZX7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

274537:BIU88 RS01640
gene id: 274537:BIU88_RS01640
uniprot id: A0A1D8D631
names: Similarity
messages: Belongs to the UPF0047 family.

274537:BIU88 RS07795
gene id: 274537:BIU88_RS07795
uniprot id: A0A1D8D8Q4
names: Similarity
messages: Belongs to the AlaDH/PNT family.

274537:BIU88 RS11720
gene id: 274537:BIU88_RS11720
uniprot id: A0A1D8D7D9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

274537:BIU88 RS06570
gene id: 274537:BIU88_RS06570
uniprot id: A0A1D8CY38
names: Function
names: Similarity
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.

274537:BIU88 RS07510
gene id: 274537:BIU88_RS07510
uniprot id: A0A1D8D730
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

274537:BIU88 RS01315
gene id: 274537:BIU88_RS01315
uniprot id: A0A1D8D3U7
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

274537:BIU88 RS00195
gene id: 274537:BIU88_RS00195
uniprot id: A0A1D8CV69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

274537:BIU88 RS11855
gene id: 274537:BIU88_RS11855
uniprot id: A0A1D8D4C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

274537:BIU88 RS06910
gene id: 274537:BIU88_RS06910
uniprot id: A0A1D8D196
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

274537:BIU88 RS10890
gene id: 274537:BIU88_RS10890
uniprot id: A0A1D8D6Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

274537:BIU88 RS05250
gene id: 274537:BIU88_RS05250
uniprot id: A0A1D8D592
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

274537:BIU88 RS12510
gene id: 274537:BIU88_RS12510
uniprot id: A0A1D8D5Z9
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

274537:BIU88 RS06230
gene id: 274537:BIU88_RS06230
uniprot id: A0A1D8DA99
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

274537:BIU88 RS08795
gene id: 274537:BIU88_RS08795
uniprot id: A0A1D8D8Z6
names: Similarity
messages: Belongs to the HepT RNase toxin family.

274537:BIU88 RS07255
gene id: 274537:BIU88_RS07255
uniprot id: A0A1D8D9C4
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS09315
gene id: 274537:BIU88_RS09315
uniprot id: A0A1D8CZE3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

274537:BIU88 RS12010
gene id: 274537:BIU88_RS12010
uniprot id: A0A1D8D8Z3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

274537:BIU88 RS05595
gene id: 274537:BIU88_RS05595
uniprot id: A0A1D8CXK3
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

274537:BIU88 RS12000
gene id: 274537:BIU88_RS12000
uniprot id: A0A1D8D0Q8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BchN/ChlN family.
messages: Binds 1 [4Fe-4S] cluster per heterodimer. The cluster is bound at the heterodimer interface by residues from both subunits.
messages: Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex.
messages: Protochlorophyllide reductase is composed of three subunits; BchL, BchN and BchB. Forms a heterotetramer of two BchB and two BchN subunits.

274537:BIU88 RS11325
gene id: 274537:BIU88_RS11325
uniprot id: A0A1D8D9P7
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

274537:BIU88 RS07415
gene id: 274537:BIU88_RS07415
uniprot id: A0A1D8CYH4
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS01960
gene id: 274537:BIU88_RS01960
uniprot id: A0A1D8CVW4
names: Similarity
messages: Belongs to the Nudix hydrolase family.

274537:BIU88 RS01900
gene id: 274537:BIU88_RS01900
uniprot id: A0A1D8CVV6
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

274537:BIU88 RS10205
gene id: 274537:BIU88_RS10205
uniprot id: A0A1D8D223
names: Similarity
messages: Belongs to the 6-phosphogluconate dehydrogenase family.

274537:BIU88 RS05835
gene id: 274537:BIU88_RS05835
uniprot id: A0A1D8CXP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

274537:BIU88 RS04555
gene id: 274537:BIU88_RS04555
uniprot id: A0A1D8D053
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

274537:BIU88 RS08890
gene id: 274537:BIU88_RS08890
uniprot id: A0A1D8CZ92
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

274537:BIU88 RS00610
gene id: 274537:BIU88_RS00610
uniprot id: A0A1D8CVC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

274537:BIU88 RS11900
gene id: 274537:BIU88_RS11900
uniprot id: A0A1D8D7G8
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS01245
gene id: 274537:BIU88_RS01245
uniprot id: A0A1D8D1C4
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

274537:BIU88 RS01505
gene id: 274537:BIU88_RS01505
uniprot id: A0A1D8CVP8
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS11470
gene id: 274537:BIU88_RS11470
uniprot id: A0A1D8D0H2
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS10875
gene id: 274537:BIU88_RS10875
uniprot id: A0A1D8D296
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

274537:BIU88 RS01415
gene id: 274537:BIU88_RS01415
uniprot id: A0A1D8CVM9
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS00875
gene id: 274537:BIU88_RS00875
uniprot id: A0A1D8D4P7
names: Similarity
messages: Belongs to the ABC transporter superfamily.

274537:BIU88 RS01795
gene id: 274537:BIU88_RS01795
uniprot id: A0A1D8D570
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS06025
gene id: 274537:BIU88_RS06025
uniprot id: A0A1D8CXU3
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

274537:BIU88 RS01370
gene id: 274537:BIU88_RS01370
uniprot id: A0A1D8D3V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS00360
gene id: 274537:BIU88_RS00360
uniprot id: A0A1D8D4I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

274537:BIU88 RS07010
gene id: 274537:BIU88_RS07010
uniprot id: A0A1D8D0I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

274537:BIU88 RS02075
gene id: 274537:BIU88_RS02075
uniprot id: A0A1D8CVY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

274537:BIU88 RS01175
gene id: 274537:BIU88_RS01175
uniprot id: A0A1D8CVJ7
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

274537:BIU88 RS09195
gene id: 274537:BIU88_RS09195
uniprot id: A0A1D8D7W6
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS02375
gene id: 274537:BIU88_RS02375
uniprot id: A0A1D8D309
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

274537:BIU88 RS09900
gene id: 274537:BIU88_RS09900
uniprot id: A0A1D8D6K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

274537:BIU88 RS00315
gene id: 274537:BIU88_RS00315
uniprot id: A0A1D8CY53
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

274537:BIU88 RS03255
gene id: 274537:BIU88_RS03255
uniprot id: A0A1D8CWH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

274537:BIU88 RS01065
gene id: 274537:BIU88_RS01065
uniprot id: A0A1D8CYH0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

274537:BIU88 RS07350
gene id: 274537:BIU88_RS07350
uniprot id: A0A1D8D4A4
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

274537:BIU88 RS00020
gene id: 274537:BIU88_RS00020
uniprot id: A0A1D8CY10
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

274537:BIU88 RS04720
gene id: 274537:BIU88_RS04720
uniprot id: A0A1D8D204
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

274537:BIU88 RS01500
gene id: 274537:BIU88_RS01500
uniprot id: A0A1D8D0J5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS01625
gene id: 274537:BIU88_RS01625
uniprot id: A0A1D8CVR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

274537:BIU88 RS04640
gene id: 274537:BIU88_RS04640
uniprot id: A0A1D8CX47
names: Similarity
messages: Belongs to the CRISPR-associated Csm4 family.

274537:BIU88 RS02835
gene id: 274537:BIU88_RS02835
uniprot id: A0A1D8CZF2
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

274537:BIU88 RS12315
gene id: 274537:BIU88_RS12315
uniprot id: A0A1D8D2Q7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS10235
gene id: 274537:BIU88_RS10235
uniprot id: A0A1D8D5B5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

274537:BIU88 RS03285
gene id: 274537:BIU88_RS03285
uniprot id: A0A1D8CWH7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

274537:BIU88 RS01120
gene id: 274537:BIU88_RS01120
uniprot id: A0A1D8CVJ0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

274537:BIU88 RS09915
gene id: 274537:BIU88_RS09915
uniprot id: A0A1D8D562
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

274537:BIU88 RS09120
gene id: 274537:BIU88_RS09120
uniprot id: A0A1D8D4U5
names: Similarity
messages: Belongs to the NadC/ModD family.

274537:BIU88 RS12425
gene id: 274537:BIU88_RS12425
uniprot id: A0A1D8D130
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

274537:BIU88 RS10085
gene id: 274537:BIU88_RS10085
uniprot id: A0A1D8D9A6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS11910
gene id: 274537:BIU88_RS11910
uniprot id: A0A1D8D0P9
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

274537:BIU88 RS12570
gene id: 274537:BIU88_RS12570
uniprot id: A0A1D8D959
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS01075
gene id: 274537:BIU88_RS01075
uniprot id: A0A1D8D637
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

274537:BIU88 RS12450
gene id: 274537:BIU88_RS12450
uniprot id: A0A1D8D112
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

274537:BIU88 RS03485
gene id: 274537:BIU88_RS03485
uniprot id: A0A1D8D4S1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

274537:BIU88 RS00790
gene id: 274537:BIU88_RS00790
uniprot id: A0A1D8CYC4
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

274537:BIU88 RS11570
gene id: 274537:BIU88_RS11570
uniprot id: A0A1D8D7A8
names: Similarity
messages: Belongs to the aspartokinase family.

274537:BIU88 RS00265
gene id: 274537:BIU88_RS00265
uniprot id: A0A1D8D4I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

274537:BIU88 RS02010
gene id: 274537:BIU88_RS02010
uniprot id: A0A1D8D413
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

274537:BIU88 RS11890
gene id: 274537:BIU88_RS11890
uniprot id: A0A1D8D0N6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

274537:BIU88 RS09305
gene id: 274537:BIU88_RS09305
uniprot id: A0A1D8D7Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

274537:BIU88 RS04400
gene id: 274537:BIU88_RS04400
uniprot id: A0A1D8D659
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

274537:BIU88 RS02670
gene id: 274537:BIU88_RS02670
uniprot id: A0A1D8CZC9
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

274537:BIU88 RS05500
gene id: 274537:BIU88_RS05500
uniprot id: A0A1D8CXJ0
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS12790
gene id: 274537:BIU88_RS12790
uniprot id: A0A1D8DA11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

274537:BIU88 RS04430
gene id: 274537:BIU88_RS04430
uniprot id: A0A1D8D1W8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

274537:BIU88 RS03965
gene id: 274537:BIU88_RS03965
uniprot id: A0A1D8CWT8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

274537:BIU88 RS10765
gene id: 274537:BIU88_RS10765
uniprot id: A0A1D8D055
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

274537:BIU88 RS07910
gene id: 274537:BIU88_RS07910
uniprot id: A0A1D8D797
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

274537:BIU88 RS05295
gene id: 274537:BIU88_RS05295
uniprot id: A0A1D8D0I1
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

274537:BIU88 RS03260
gene id: 274537:BIU88_RS03260
uniprot id: A0A1D8D2X4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

274537:BIU88 RS12335
gene id: 274537:BIU88_RS12335
uniprot id: A0A1D8D4H0
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS03210
gene id: 274537:BIU88_RS03210
uniprot id: A0A1D8D2W5
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

274537:BIU88 RS11335
gene id: 274537:BIU88_RS11335
uniprot id: A0A1D8D2F0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

274537:BIU88 RS07260
gene id: 274537:BIU88_RS07260
uniprot id: A0A1D8CYE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

274537:BIU88 RS12780
gene id: 274537:BIU88_RS12780
uniprot id: A0A1D8D626
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

274537:BIU88 RS12005
gene id: 274537:BIU88_RS12005
uniprot id: A0A1D8D5V1
names: Similarity
messages: Belongs to the UPF0045 family.

274537:BIU88 RS11850
gene id: 274537:BIU88_RS11850
uniprot id: A0A1D8D7F8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS04560
gene id: 274537:BIU88_RS04560
uniprot id: A0A1D8D4V2
names: Similarity
messages: Belongs to the UPF0251 family.

274537:BIU88 RS02550
gene id: 274537:BIU88_RS02550
uniprot id: A0A1D8CW53
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

274537:BIU88 RS03045
gene id: 274537:BIU88_RS03045
uniprot id: A0A1D8CWE9
names: Similarity
messages: Belongs to the ModE family.

274537:BIU88 RS00030
gene id: 274537:BIU88_RS00030
uniprot id: A0A1D8CZU9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

274537:BIU88 RS10855
gene id: 274537:BIU88_RS10855
uniprot id: A0A1D8D8N4
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

274537:BIU88 RS05320
gene id: 274537:BIU88_RS05320
uniprot id: A0A1D8D3N5
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

274537:BIU88 RS01470
gene id: 274537:BIU88_RS01470
uniprot id: A0A1D8CVN8
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

274537:BIU88 RS01785
gene id: 274537:BIU88_RS01785
uniprot id: A0A1D8CVU1
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS01055
gene id: 274537:BIU88_RS01055
uniprot id: A0A1D8CXN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

274537:BIU88 RS12120
gene id: 274537:BIU88_RS12120
uniprot id: A0A1D8D901
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

274537:BIU88 RS03410
gene id: 274537:BIU88_RS03410
uniprot id: A0A1D8CWK0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS08190
gene id: 274537:BIU88_RS08190
uniprot id: A0A1D8D623
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

274537:BIU88 RS00490
gene id: 274537:BIU88_RS00490
uniprot id: A0A1D8D5T3
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

274537:BIU88 RS11520
gene id: 274537:BIU88_RS11520
uniprot id: A0A1D8D0I2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS10665
gene id: 274537:BIU88_RS10665
uniprot id: A0A1D8D3Z4
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

274537:BIU88 RS00330
gene id: 274537:BIU88_RS00330
uniprot id: A0A1D8CV88
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

274537:BIU88 RS10430
gene id: 274537:BIU88_RS10430
uniprot id: A0A1D8D247
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

274537:BIU88 RS07430
gene id: 274537:BIU88_RS07430
uniprot id: A0A1D8D721
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

274537:BIU88 RS01135
gene id: 274537:BIU88_RS01135
uniprot id: A0A1D8D3S7
names: Similarity
messages: Belongs to the DprA/Smf family.

274537:BIU88 RS03195
gene id: 274537:BIU88_RS03195
uniprot id: A0A1D8DA61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS09075
gene id: 274537:BIU88_RS09075
uniprot id: A0A1D8D916
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

274537:BIU88 RS11690
gene id: 274537:BIU88_RS11690
uniprot id: A0A1D8D8X4
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

274537:BIU88 RS09825
gene id: 274537:BIU88_RS09825
uniprot id: A0A1D8CZP5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

274537:BIU88 RS07405
gene id: 274537:BIU88_RS07405
uniprot id: A0A1D8D368
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

274537:BIU88 RS01485
gene id: 274537:BIU88_RS01485
uniprot id: A0A1D8CVP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Membrane

274537:BIU88 RS10755
gene id: 274537:BIU88_RS10755
uniprot id: A0A1D8D283
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

274537:BIU88 RS12635
gene id: 274537:BIU88_RS12635
uniprot id: A0A1D8D159
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

274537:BIU88 RS11990
gene id: 274537:BIU88_RS11990
uniprot id: A0A1D8D7I5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
messages: Homodimer. Protochlorophyllide reductase is composed of three subunits; BchL, BchN and BchB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS11865
gene id: 274537:BIU88_RS11865
uniprot id: A0A1D8D5U1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

274537:BIU88 RS11355
gene id: 274537:BIU88_RS11355
uniprot id: A0A1D8D486
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

274537:BIU88 RS00680
gene id: 274537:BIU88_RS00680
uniprot id: A0A1D8D3M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS01595
gene id: 274537:BIU88_RS01595
uniprot id: A0A1D8CVQ7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS09240
gene id: 274537:BIU88_RS09240
uniprot id: A0A1D8D3I5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

274537:BIU88 RS12175
gene id: 274537:BIU88_RS12175
uniprot id: A0A1D8D0U1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

274537:BIU88 RS12125
gene id: 274537:BIU88_RS12125
uniprot id: A0A1D8D9X7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

274537:BIU88 RS08920
gene id: 274537:BIU88_RS08920
uniprot id: A0A1D8D1F9
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS12215
gene id: 274537:BIU88_RS12215
uniprot id: A0A1D8D7M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

274537:BIU88 RS01290
gene id: 274537:BIU88_RS01290
uniprot id: A0A1D8CXR9
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

274537:BIU88 RS01805
gene id: 274537:BIU88_RS01805
uniprot id: A0A1D8D644
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

274537:BIU88 RS11400
gene id: 274537:BIU88_RS11400
uniprot id: A0A1D8D304
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

274537:BIU88 RS06440
gene id: 274537:BIU88_RS06440
uniprot id: A0A1D8D836
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS02680
gene id: 274537:BIU88_RS02680
uniprot id: A0A1D8D164
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS11290
gene id: 274537:BIU88_RS11290
uniprot id: A0A1D8D2Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

274537:BIU88 RS00385
gene id: 274537:BIU88_RS00385
uniprot id: A0A1D8CV85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

274537:BIU88 RS10545
gene id: 274537:BIU88_RS10545
uniprot id: A0A1D8D019
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

274537:BIU88 RS00010
gene id: 274537:BIU88_RS00010
uniprot id: A0A1D8CX59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

274537:BIU88 RS05260
gene id: 274537:BIU88_RS05260
uniprot id: A0A1D8CXF2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

274537:BIU88 RS06275
gene id: 274537:BIU88_RS06275
uniprot id: A0A1D8CXY8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

274537:BIU88 RS04120
gene id: 274537:BIU88_RS04120
uniprot id: A0A1D8D726
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS12495
gene id: 274537:BIU88_RS12495
uniprot id: A0A1D8D7R4
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

274537:BIU88 RS05985
gene id: 274537:BIU88_RS05985
uniprot id: A0A1D8D6F5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SoxA family.
messages: Binds 1 heme group per subunit.
messages: Binds 2 heme groups per subunit.
messages: C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the liberation of two electrons, which may be transferred from the SoxAX complex to another cytochrome c and which then may be used for reductive CO(2) fixation.
messages: Heterodimer of SoxA and SoxX.
messages: Periplasm

274537:BIU88 RS03850
gene id: 274537:BIU88_RS03850
uniprot id: A0A1D8CWS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

274537:BIU88 RS08410
gene id: 274537:BIU88_RS08410
uniprot id: A0A1D8D7I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

274537:BIU88 RS09235
gene id: 274537:BIU88_RS09235
uniprot id: A0A1D8D699
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

274537:BIU88 RS12550
gene id: 274537:BIU88_RS12550
uniprot id: A0A1D8D4I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

274537:BIU88 RS02690
gene id: 274537:BIU88_RS02690
uniprot id: A0A1D8D2R1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

274537:BIU88 RS08195
gene id: 274537:BIU88_RS08195
uniprot id: A0A1D8D356
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS09080
gene id: 274537:BIU88_RS09080
uniprot id: A0A1D8CZA4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

274537:BIU88 RS02980
gene id: 274537:BIU88_RS02980
uniprot id: A0A1D8D6I3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

274537:BIU88 RS06870
gene id: 274537:BIU88_RS06870
uniprot id: A0A1D8D8A6
names: Similarity
messages: Belongs to the HepT RNase toxin family.

274537:BIU88 RS02915
gene id: 274537:BIU88_RS02915
uniprot id: A0A1D8D5M0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

274537:BIU88 RS03435
gene id: 274537:BIU88_RS03435
uniprot id: A0A1D8CWK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

274537:BIU88 RS10285
gene id: 274537:BIU88_RS10285
uniprot id: A0A1D8D525
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

274537:BIU88 RS02275
gene id: 274537:BIU88_RS02275
uniprot id: A0A1D8CZ39
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

274537:BIU88 RS04880
gene id: 274537:BIU88_RS04880
uniprot id: A0A1D8D225
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

274537:BIU88 RS08465
gene id: 274537:BIU88_RS08465
uniprot id: A0A1D8DAD6
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS09905
gene id: 274537:BIU88_RS09905
uniprot id: A0A1D8D3R6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

274537:BIU88 RS07100
gene id: 274537:BIU88_RS07100
uniprot id: A0A1D8D5T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

274537:BIU88 RS07005
gene id: 274537:BIU88_RS07005
uniprot id: A0A1D8CYB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

274537:BIU88 RS02185
gene id: 274537:BIU88_RS02185
uniprot id: A0A1D8CVZ6
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS04755
gene id: 274537:BIU88_RS04755
uniprot id: A0A1D8CZF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kinesin light chain family.
messages: cytoskeleton

274537:BIU88 RS01490
gene id: 274537:BIU88_RS01490
uniprot id: A0A1D8CYP7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

274537:BIU88 RS03275
gene id: 274537:BIU88_RS03275
uniprot id: A0A1D8CWI2
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

274537:BIU88 RS12190
gene id: 274537:BIU88_RS12190
uniprot id: A0A1D8D9Y0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

274537:BIU88 RS02065
gene id: 274537:BIU88_RS02065
uniprot id: A0A1D8D424
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

274537:BIU88 RS07090
gene id: 274537:BIU88_RS07090
uniprot id: A0A1D8CYB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

274537:BIU88 RS08540
gene id: 274537:BIU88_RS08540
uniprot id: A0A1D8CZ47
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

274537:BIU88 RS04930
gene id: 274537:BIU88_RS04930
uniprot id: A0A1D8D549
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

274537:BIU88 RS01095
gene id: 274537:BIU88_RS01095
uniprot id: A0A1D8D4T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

274537:BIU88 RS09580
gene id: 274537:BIU88_RS09580
uniprot id: A0A1D8CZJ4
names: Subcellular Location Annotation
messages: Membrane

274537:BIU88 RS09980
gene id: 274537:BIU88_RS09980
uniprot id: A0A1D8D999
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

274537:BIU88 RS06370
gene id: 274537:BIU88_RS06370
uniprot id: A0A1D8D3Z2
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

274537:BIU88 RS11230
gene id: 274537:BIU88_RS11230
uniprot id: A0A1D8D0D1
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

274537:BIU88 RS03430
gene id: 274537:BIU88_RS03430
uniprot id: A0A1D8D1G8
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

274537:BIU88 RS08930
gene id: 274537:BIU88_RS08930
uniprot id: A0A1D8D4Z7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

274537:BIU88 RS12535
gene id: 274537:BIU88_RS12535
uniprot id: A0A1D8D145
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

274537:BIU88 RS12395
gene id: 274537:BIU88_RS12395
uniprot id: A0A1D8D0Z8
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

274537:BIU88 RS04525
gene id: 274537:BIU88_RS04525
uniprot id: A0A1D8D787
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

274537:BIU88 RS07915
gene id: 274537:BIU88_RS07915
uniprot id: A0A1D8D8S7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

274537:BIU88 RS09265
gene id: 274537:BIU88_RS09265
uniprot id: A0A1D8CZD1
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

274537:BIU88 RS02635
gene id: 274537:BIU88_RS02635
uniprot id: A0A1D8CW77
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

274537:BIU88 RS09830
gene id: 274537:BIU88_RS09830
uniprot id: A0A1D8D1X2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

274537:BIU88 RS12475
gene id: 274537:BIU88_RS12475
uniprot id: A0A1D8D114
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

274537:BIU88 RS09840
gene id: 274537:BIU88_RS09840
uniprot id: A0A1D8D2G7
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

274537:BIU88 RS04115
gene id: 274537:BIU88_RS04115
uniprot id: A0A1D8D5X4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

274537:BIU88 RS10595
gene id: 274537:BIU88_RS10595
uniprot id: A0A1D8D027
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

274537:BIU88 RS03710
gene id: 274537:BIU88_RS03710
uniprot id: A0A1D8D5U3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

274537:BIU88 RS06145
gene id: 274537:BIU88_RS06145
uniprot id: A0A1D8D3X3
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

274537:BIU88 RS12220
gene id: 274537:BIU88_RS12220
uniprot id: A0A1D8D4G0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

274537:BIU88 RS02435
gene id: 274537:BIU88_RS02435
uniprot id: A0A1D8CY79
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

274537:BIU88 RS12225
gene id: 274537:BIU88_RS12225
uniprot id: A0A1D8D0V6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

274537:BIU88 RS07890
gene id: 274537:BIU88_RS07890
uniprot id: A0A1D8D324
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

274537:BIU88 RS07240
gene id: 274537:BIU88_RS07240
uniprot id: A0A1D8D8G8
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

274537:BIU88 RS03250
gene id: 274537:BIU88_RS03250
uniprot id: A0A1D8D1E1
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

274537:BIU88 RS10095
gene id: 274537:BIU88_RS10095
uniprot id: A0A1D8D210
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

274537:BIU88 RS01310
gene id: 274537:BIU88_RS01310
uniprot id: A0A1D8CYK2
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

274537:BIU88 RS02050
gene id: 274537:BIU88_RS02050
uniprot id: A0A1D8CY17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

274537:BIU88 RS02040
gene id: 274537:BIU88_RS02040
uniprot id: A0A1D8D660
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

274537:BIU88 RS04155
gene id: 274537:BIU88_RS04155
uniprot id: A0A1D8CWW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

274537:BIU88 RS12365
gene id: 274537:BIU88_RS12365
uniprot id: A0A1D8D9H5
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

274537:BIU88 RS02480
gene id: 274537:BIU88_RS02480
uniprot id: A0A1D8D5G5
names: Function
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.

274537:BIU88 RS03830
gene id: 274537:BIU88_RS03830
uniprot id: A0A1D8D1I0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

274537:BIU88 RS00090
gene id: 274537:BIU88_RS00090
uniprot id: A0A1D8D1S6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

274537:BIU88 RS03550
gene id: 274537:BIU88_RS03550
uniprot id: A0A1D8D303
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

274537:BIU88 RS03820
gene id: 274537:BIU88_RS03820
uniprot id: A0A1D8D326
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

274537:BIU88 RS02030
gene id: 274537:BIU88_RS02030
uniprot id: A0A1D8D1D7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

274537:BIU88 RS11310
gene id: 274537:BIU88_RS11310
uniprot id: A0A1D8D0E1
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. ChlP subfamily.

274537:BIU88 RS03985
gene id: 274537:BIU88_RS03985
uniprot id: A0A1D8CWU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

274537:BIU88 RS05540
gene id: 274537:BIU88_RS05540
uniprot id: A0A1D8DA89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

274537:BIU88 RS12205
gene id: 274537:BIU88_RS12205
uniprot id: A0A1D8D0T5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

274537:BIU88 RS11825
gene id: 274537:BIU88_RS11825
uniprot id: A0A1D8D0P1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

274537:BIU88 RS02390
gene id: 274537:BIU88_RS02390
uniprot id: A0A1D8CZ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

274537:BIU88 RS06850
gene id: 274537:BIU88_RS06850
uniprot id: A0A1D8CY93
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.