273116:TVG RS00460
gene id: 273116:TVG_RS00460
uniprot id: Q97CL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

273116:TVG RS03760
gene id: 273116:TVG_RS03760
uniprot id: Q97AV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

273116:TVG RS00395
gene id: 273116:TVG_RS00395
uniprot id: Q97CM5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

273116:TVG RS00115
gene id: 273116:TVG_RS00115
uniprot id: Q97CS8
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS05540
gene id: 273116:TVG_RS05540
uniprot id: Q979U9
names: Similarity
messages: Belongs to the MCM family.

273116:TVG RS01505
gene id: 273116:TVG_RS01505
uniprot id: Q97C15
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

273116:TVG RS04225
gene id: 273116:TVG_RS04225
uniprot id: Q97AL2
names: Similarity
messages: Belongs to the TPP enzyme family.

273116:TVG RS05995
gene id: 273116:TVG_RS05995
uniprot id: Q979L6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

273116:TVG RS01650
gene id: 273116:TVG_RS01650
uniprot id: Q97BY8
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273116:TVG RS01745
gene id: 273116:TVG_RS01745
uniprot id: Q97BW9
names: Similarity
messages: Belongs to the SUI1 family.

273116:TVG RS04400
gene id: 273116:TVG_RS04400
uniprot id: Q97AI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

273116:TVG RS00180
gene id: 273116:TVG_RS00180
uniprot id: Q97CR5
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

273116:TVG RS01470
gene id: 273116:TVG_RS01470
uniprot id: Q97C22
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

273116:TVG RS07440
gene id: 273116:TVG_RS07440
uniprot id: Q978J5
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

273116:TVG RS01780
gene id: 273116:TVG_RS01780
uniprot id: Q97BW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

273116:TVG RS01400
gene id: 273116:TVG_RS01400
uniprot id: Q97C35
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

273116:TVG RS03265
gene id: 273116:TVG_RS03265
uniprot id: Q97B39
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

273116:TVG RS06540
gene id: 273116:TVG_RS06540
uniprot id: Q979B7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

273116:TVG RS04330
gene id: 273116:TVG_RS04330
uniprot id: Q97AJ1
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS03400
gene id: 273116:TVG_RS03400
uniprot id: Q97B13
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

273116:TVG RS06565
gene id: 273116:TVG_RS06565
uniprot id: P58232
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

273116:TVG RS06310
gene id: 273116:TVG_RS06310
uniprot id: Q979F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

273116:TVG RS06820
gene id: 273116:TVG_RS06820
uniprot id: Q978W7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

273116:TVG RS07195
gene id: 273116:TVG_RS07195
uniprot id: Q978P5
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

273116:TVG RS02400
gene id: 273116:TVG_RS02400
uniprot id: Q97BJ5
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273116:TVG RS01735
gene id: 273116:TVG_RS01735
uniprot id: Q97BX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

273116:TVG RS01045
gene id: 273116:TVG_RS01045
uniprot id: P58306
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm

273116:TVG RS06135
gene id: 273116:TVG_RS06135
uniprot id: Q979J0
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS02730
gene id: 273116:TVG_RS02730
uniprot id: Q97BD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

273116:TVG RS00660
gene id: 273116:TVG_RS00660
uniprot id: Q97CH4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

273116:TVG RS00315
gene id: 273116:TVG_RS00315
uniprot id: Q97CP1
names: Function
names: Similarity
messages: Belongs to the type-2 OGG1 family.
messages: Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites). Prefers oligomers containing 8-oxoG:C, 8-oxoG:T and 8-oxoG:G base pairs, and is less effective on oligomers containing 8-oxoG:A mispairs.

273116:TVG RS00570
gene id: 273116:TVG_RS00570
uniprot id: Q97CJ2
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

273116:TVG RS01730
gene id: 273116:TVG_RS01730
uniprot id: Q97BX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

273116:TVG RS05470
gene id: 273116:TVG_RS05470
uniprot id: Q979W3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

273116:TVG RS01615
gene id: 273116:TVG_RS01615
uniprot id: Q97BZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

273116:TVG RS07345
gene id: 273116:TVG_RS07345
uniprot id: Q978L4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

273116:TVG RS07445
gene id: 273116:TVG_RS07445
uniprot id: Q978J4
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS07115
gene id: 273116:TVG_RS07115
uniprot id: Q978R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

273116:TVG RS00865
gene id: 273116:TVG_RS00865
uniprot id: Q97CD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

273116:TVG RS02620
gene id: 273116:TVG_RS02620
uniprot id: Q97BF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

273116:TVG RS06260
gene id: 273116:TVG_RS06260
uniprot id: Q979G5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

273116:TVG RS05110
gene id: 273116:TVG_RS05110
uniprot id: Q97A32
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

273116:TVG RS02995
gene id: 273116:TVG_RS02995
uniprot id: Q97B87
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

273116:TVG RS04420
gene id: 273116:TVG_RS04420
uniprot id: Q97AH8
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS00465
gene id: 273116:TVG_RS00465
uniprot id: Q97CL3
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

273116:TVG RS01755
gene id: 273116:TVG_RS01755
uniprot id: Q97BW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

273116:TVG RS02785
gene id: 273116:TVG_RS02785
uniprot id: Q97BC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

273116:TVG RS00240
gene id: 273116:TVG_RS00240
uniprot id: Q97CQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

273116:TVG RS05655
gene id: 273116:TVG_RS05655
uniprot id: Q979T0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

273116:TVG RS06510
gene id: 273116:TVG_RS06510
uniprot id: Q979C3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

273116:TVG RS05250
gene id: 273116:TVG_RS05250
uniprot id: Q97A04
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

273116:TVG RS06830
gene id: 273116:TVG_RS06830
uniprot id: Q978W5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

273116:TVG RS05875
gene id: 273116:TVG_RS05875
uniprot id: Q979P1
names: Cofactor
messages: Binds 1 zinc ion per subunit.

273116:TVG RS03970
gene id: 273116:TVG_RS03970
uniprot id: Q97AR3
names: Subcellular Location Annotation
messages: Cell membrane

273116:TVG RS06070
gene id: 273116:TVG_RS06070
uniprot id: Q979K3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

273116:TVG RS02840
gene id: 273116:TVG_RS02840
uniprot id: Q97BB5
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

273116:TVG RS01940
gene id: 273116:TVG_RS01940
uniprot id: Q97BS8
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS06080
gene id: 273116:TVG_RS06080
uniprot id: Q979K1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

273116:TVG RS01630
gene id: 273116:TVG_RS01630
uniprot id: Q97BZ2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

273116:TVG RS00915
gene id: 273116:TVG_RS00915
uniprot id: Q97CC8
names: Similarity
messages: Belongs to the thymidylate kinase family.

273116:TVG RS01110
gene id: 273116:TVG_RS01110
uniprot id: Q97C90
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

273116:TVG RS07300
gene id: 273116:TVG_RS07300
uniprot id: Q978M2
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS05880
gene id: 273116:TVG_RS05880
uniprot id: Q979P0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

273116:TVG RS04870
gene id: 273116:TVG_RS04870
uniprot id: Q97A89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

273116:TVG RS01655
gene id: 273116:TVG_RS01655
uniprot id: Q97BY7
names: Similarity
messages: Belongs to the band 7/mec-2 family.

273116:TVG RS06560
gene id: 273116:TVG_RS06560
uniprot id: Q979B3
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS01250
gene id: 273116:TVG_RS01250
uniprot id: Q97C64
names: Similarity
messages: Belongs to the citrate synthase family.

273116:TVG RS02850
gene id: 273116:TVG_RS02850
uniprot id: Q97BB3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

273116:TVG RS02520
gene id: 273116:TVG_RS02520
uniprot id: Q97BH3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

273116:TVG RS00285
gene id: 273116:TVG_RS00285
uniprot id: Q97CP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

273116:TVG RS02170
gene id: 273116:TVG_RS02170
uniprot id: Q97BN6
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

273116:TVG RS00580
gene id: 273116:TVG_RS00580
uniprot id: Q97CJ0
names: Similarity
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.

273116:TVG RS01765
gene id: 273116:TVG_RS01765
uniprot id: Q97BW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

273116:TVG RS06570
gene id: 273116:TVG_RS06570
uniprot id: Q979B2
names: Similarity
messages: Belongs to the UPF0179 family.

273116:TVG RS01560
gene id: 273116:TVG_RS01560
uniprot id: Q97C04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

273116:TVG RS02800
gene id: 273116:TVG_RS02800
uniprot id: Q97BC1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

273116:TVG RS05225
gene id: 273116:TVG_RS05225
uniprot id: Q97A09
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

273116:TVG RS05175
gene id: 273116:TVG_RS05175
uniprot id: Q97A19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

273116:TVG RS03410
gene id: 273116:TVG_RS03410
uniprot id: Q97B11
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

273116:TVG RS05585
gene id: 273116:TVG_RS05585
uniprot id: Q979U1
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS06975
gene id: 273116:TVG_RS06975
uniprot id: Q978T7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

273116:TVG RS02100
gene id: 273116:TVG_RS02100
uniprot id: Q97BQ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: In the C-terminal section; belongs to the YjjX NTPase family.
messages: In the N-terminal section; belongs to the eukaryotic CoaD family.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

273116:TVG RS00095
gene id: 273116:TVG_RS00095
uniprot id: Q97CT2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

273116:TVG RS08000
gene id: 273116:TVG_RS08000
uniprot id: Q977Z9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

273116:TVG RS05480
gene id: 273116:TVG_RS05480
uniprot id: Q979W1
names: Similarity
messages: Belongs to the pyruvate kinase family.

273116:TVG RS02960
gene id: 273116:TVG_RS02960
uniprot id: Q97B93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

273116:TVG RS02990
gene id: 273116:TVG_RS02990
uniprot id: Q97B88
names: Similarity
messages: Belongs to the TFIIB family.

273116:TVG RS00530
gene id: 273116:TVG_RS00530
uniprot id: Q97CK0
names: Similarity
messages: Belongs to the BCKDHA family.

273116:TVG RS02545
gene id: 273116:TVG_RS02545
uniprot id: Q97BG8
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

273116:TVG RS05925
gene id: 273116:TVG_RS05925
uniprot id: Q979N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

273116:TVG RS00145
gene id: 273116:TVG_RS00145
uniprot id: Q97CS2
names: Similarity
messages: Belongs to the peptidase S49 family.

273116:TVG RS01785
gene id: 273116:TVG_RS01785
uniprot id: Q97BW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

273116:TVG RS04580
gene id: 273116:TVG_RS04580
uniprot id: Q97AE6
names: Similarity
messages: Belongs to the UPF0173 family.

273116:TVG RS01750
gene id: 273116:TVG_RS01750
uniprot id: Q97BW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

273116:TVG RS03040
gene id: 273116:TVG_RS03040
uniprot id: Q97B79
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

273116:TVG RS03965
gene id: 273116:TVG_RS03965
uniprot id: Q97AR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

273116:TVG RS04530
gene id: 273116:TVG_RS04530
uniprot id: Q97AF6
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

273116:TVG RS01605
gene id: 273116:TVG_RS01605
uniprot id: Q97BZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

273116:TVG RS07365
gene id: 273116:TVG_RS07365
uniprot id: Q978L0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

273116:TVG RS05450
gene id: 273116:TVG_RS05450
uniprot id: Q979W7
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS00625
gene id: 273116:TVG_RS00625
uniprot id: Q97CI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

273116:TVG RS01375
gene id: 273116:TVG_RS01375
uniprot id: Q97C40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

273116:TVG RS05980
gene id: 273116:TVG_RS05980
uniprot id: Q979L9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

273116:TVG RS04255
gene id: 273116:TVG_RS04255
uniprot id: Q97AK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

273116:TVG RS07030
gene id: 273116:TVG_RS07030
uniprot id: Q978S6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

273116:TVG RS07455
gene id: 273116:TVG_RS07455
uniprot id: Q978J2
names: Similarity
messages: Belongs to the CutA family.

273116:TVG RS05505
gene id: 273116:TVG_RS05505
uniprot id: Q979V6
names: Similarity
messages: Belongs to the TrpF family.

273116:TVG RS06865
gene id: 273116:TVG_RS06865
uniprot id: Q978V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

273116:TVG RS06420
gene id: 273116:TVG_RS06420
uniprot id: Q979E0
names: Similarity
messages: Belongs to the TPP enzyme family.

273116:TVG RS02910
gene id: 273116:TVG_RS02910
uniprot id: Q97BA2
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

273116:TVG RS01420
gene id: 273116:TVG_RS01420
uniprot id: Q97C31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

273116:TVG RS00560
gene id: 273116:TVG_RS00560
uniprot id: Q97CJ4
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

273116:TVG RS05200
gene id: 273116:TVG_RS05200
uniprot id: Q97A14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

273116:TVG RS01070
gene id: 273116:TVG_RS01070
uniprot id: Q97C98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

273116:TVG RS07630
gene id: 273116:TVG_RS07630
uniprot id: Q978G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

273116:TVG RS01770
gene id: 273116:TVG_RS01770
uniprot id: Q97BW4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

273116:TVG RS00390
gene id: 273116:TVG_RS00390
uniprot id: Q97CM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm

273116:TVG RS01600
gene id: 273116:TVG_RS01600
uniprot id: Q97BZ7
names: Similarity
messages: Belongs to the SDO1/SBDS family.

273116:TVG RS05490
gene id: 273116:TVG_RS05490
uniprot id: Q979V9
names: Similarity
messages: Belongs to the TrpC family.

273116:TVG RS01720
gene id: 273116:TVG_RS01720
uniprot id: Q97BX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

273116:TVG RS00265
gene id: 273116:TVG_RS00265
uniprot id: Q97CQ0
names: Function
names: Miscellaneous
names: PTM
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.
messages: The intein interrupts the ATP-binding site.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation.

273116:TVG RS01555
gene id: 273116:TVG_RS01555
uniprot id: Q97C05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

273116:TVG RS02775
gene id: 273116:TVG_RS02775
uniprot id: Q97BC6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

273116:TVG RS00295
gene id: 273116:TVG_RS00295
uniprot id: Q97CP4
names: Similarity
messages: Belongs to the GcvT family.

273116:TVG RS04175
gene id: 273116:TVG_RS04175
uniprot id: Q97AM2
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

273116:TVG RS02195
gene id: 273116:TVG_RS02195
uniprot id: Q97BN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

273116:TVG RS07410
gene id: 273116:TVG_RS07410
uniprot id: Q978K1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

273116:TVG RS04115
gene id: 273116:TVG_RS04115
uniprot id: Q97AN7
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

273116:TVG RS02300
gene id: 273116:TVG_RS02300
uniprot id: Q97BL3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

273116:TVG RS05310
gene id: 273116:TVG_RS05310
uniprot id: Q979Z2
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Calcium-gated potassium channel. Can also be activated by Mg(2+), Mn(2+) and Ni(2+).
messages: Cell membrane
messages: Heterooctamer composed of four full-length subunits and four soluble RCK domains.
messages: Starts at UUG codon.

273116:TVG RS04035
gene id: 273116:TVG_RS04035
uniprot id: Q97AQ1
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

273116:TVG RS07050
gene id: 273116:TVG_RS07050
uniprot id: Q978S2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

273116:TVG RS00705
gene id: 273116:TVG_RS00705
uniprot id: Q97CG6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

273116:TVG RS03235
gene id: 273116:TVG_RS03235
uniprot id: Q97B45
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS02795
gene id: 273116:TVG_RS02795
uniprot id: Q97BC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

273116:TVG RS02380
gene id: 273116:TVG_RS02380
uniprot id: Q97BJ9
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

273116:TVG RS01450
gene id: 273116:TVG_RS01450
uniprot id: Q97C26
names: Similarity
messages: Belongs to the UPF0200 family.

273116:TVG RS02110
gene id: 273116:TVG_RS02110
uniprot id: Q97BP8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

273116:TVG RS05465
gene id: 273116:TVG_RS05465
uniprot id: Q979W4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

273116:TVG RS06625
gene id: 273116:TVG_RS06625
uniprot id: Q979A1
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

273116:TVG RS00545
gene id: 273116:TVG_RS00545
uniprot id: Q97CJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

273116:TVG RS02515
gene id: 273116:TVG_RS02515
uniprot id: Q97BH4
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit.

273116:TVG RS01760
gene id: 273116:TVG_RS01760
uniprot id: Q97BW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

273116:TVG RS02650
gene id: 273116:TVG_RS02650
uniprot id: Q97BE9
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

273116:TVG RS06475
gene id: 273116:TVG_RS06475
uniprot id: Q979D0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

273116:TVG RS04280
gene id: 273116:TVG_RS04280
uniprot id: Q97AK1
names: Similarity
messages: Belongs to the AOR/FOR family.

273116:TVG RS03310
gene id: 273116:TVG_RS03310
uniprot id: Q97B30
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

273116:TVG RS06330
gene id: 273116:TVG_RS06330
uniprot id: Q979F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

273116:TVG RS00270
gene id: 273116:TVG_RS00270
uniprot id: Q97CP9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

273116:TVG RS01620
gene id: 273116:TVG_RS01620
uniprot id: Q97BZ3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

273116:TVG RS01380
gene id: 273116:TVG_RS01380
uniprot id: Q97C39
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.

273116:TVG RS00450
gene id: 273116:TVG_RS00450
uniprot id: Q97CL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity).
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis (By similarity).

273116:TVG RS02750
gene id: 273116:TVG_RS02750
uniprot id: Q97BD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

273116:TVG RS05670
gene id: 273116:TVG_RS05670
uniprot id: Q979S7
names: Similarity
messages: Belongs to the arsA ATPase family.

273116:TVG RS01160
gene id: 273116:TVG_RS01160
uniprot id: Q97C80
names: Subcellular Location Annotation
messages: Cytoplasm

273116:TVG RS00020
gene id: 273116:TVG_RS00020
uniprot id: Q97CU7
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

273116:TVG RS07540
gene id: 273116:TVG_RS07540
uniprot id: Q978H7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

273116:TVG RS02615
gene id: 273116:TVG_RS02615
uniprot id: Q97BF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

273116:TVG RS01310
gene id: 273116:TVG_RS01310
uniprot id: Q97C54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

273116:TVG RS01705
gene id: 273116:TVG_RS01705
uniprot id: Q97BX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

273116:TVG RS07780
gene id: 273116:TVG_RS07780
uniprot id: Q978D8
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS00550
gene id: 273116:TVG_RS00550
uniprot id: Q97CJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

273116:TVG RS00255
gene id: 273116:TVG_RS00255
uniprot id: Q97CQ2
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

273116:TVG RS05090
gene id: 273116:TVG_RS05090
uniprot id: Q97A37
names: Similarity
messages: Belongs to the DtxR/MntR family.

273116:TVG RS05650
gene id: 273116:TVG_RS05650
uniprot id: Q979T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

273116:TVG RS00535
gene id: 273116:TVG_RS00535
uniprot id: Q97CJ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

273116:TVG RS05625
gene id: 273116:TVG_RS05625
uniprot id: Q979T6
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

273116:TVG RS02460
gene id: 273116:TVG_RS02460
uniprot id: Q97BI5
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS03385
gene id: 273116:TVG_RS03385
uniprot id: Q97B16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

273116:TVG RS02085
gene id: 273116:TVG_RS02085
uniprot id: Q97BQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity).
messages: Homodimer.

273116:TVG RS02935
gene id: 273116:TVG_RS02935
uniprot id: Q97B98
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

273116:TVG RS05045
gene id: 273116:TVG_RS05045
uniprot id: Q97A46
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS03160
gene id: 273116:TVG_RS03160
uniprot id: Q97B59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

273116:TVG RS07250
gene id: 273116:TVG_RS07250
uniprot id: Q978N3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

273116:TVG RS05845
gene id: 273116:TVG_RS05845
uniprot id: Q979P7
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

273116:TVG RS01485
gene id: 273116:TVG_RS01485
uniprot id: Q97C19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

273116:TVG RS01030
gene id: 273116:TVG_RS01030
uniprot id: Q97CA5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

273116:TVG RS04210
gene id: 273116:TVG_RS04210
uniprot id: Q97AL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA (By similarity).
messages: In the C-terminal section; belongs to the endonuclease V family.
messages: In the N-terminal section; belongs to the MGMT family.

273116:TVG RS03025
gene id: 273116:TVG_RS03025
uniprot id: Q97B81
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

273116:TVG RS02835
gene id: 273116:TVG_RS02835
uniprot id: Q97BB6
names: Similarity
messages: Belongs to the type II topoisomerase GyrB family.

273116:TVG RS07155
gene id: 273116:TVG_RS07155
uniprot id: Q978Q3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

273116:TVG RS04335
gene id: 273116:TVG_RS04335
uniprot id: Q97AJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

273116:TVG RS03370
gene id: 273116:TVG_RS03370
uniprot id: Q97B19
names: Function
names: Similarity
messages: Belongs to the thermophilic archaeal actin family.
messages: Polymerizes into bundles of filaments. Polymerization requires NTP and is optimal with ATP, but GTP, UTP, CTP, and even the deoxy form of NTP can also support the polymerization reaction (By similarity).

273116:TVG RS00260
gene id: 273116:TVG_RS00260
uniprot id: Q97CQ1
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

273116:TVG RS06855
gene id: 273116:TVG_RS06855
uniprot id: Q978W0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

273116:TVG RS00515
gene id: 273116:TVG_RS00515
uniprot id: Q97CK3
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

273116:TVG RS01800
gene id: 273116:TVG_RS01800
uniprot id: Q97BV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

273116:TVG RS06180
gene id: 273116:TVG_RS06180
uniprot id: Q979I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

273116:TVG RS00825
gene id: 273116:TVG_RS00825
uniprot id: P58275
names: Caution
names: Similarity
messages: Belongs to the peptidase S16 family.
messages: Lacks the conserved Ser-Lys catalytic dyad essential for proteolytic activity. Its enzyme activity is therefore unsure.

273116:TVG RS02165
gene id: 273116:TVG_RS02165
uniprot id: Q97BN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cytoplasm
messages: Homodimer or homotetramer.

273116:TVG RS05350
gene id: 273116:TVG_RS05350
uniprot id: Q979Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

273116:TVG RS04125
gene id: 273116:TVG_RS04125
uniprot id: Q97AN3
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

273116:TVG RS06515
gene id: 273116:TVG_RS06515
uniprot id: Q979C2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

273116:TVG RS00085
gene id: 273116:TVG_RS00085
uniprot id: Q97CT4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

273116:TVG RS06915
gene id: 273116:TVG_RS06915
uniprot id: Q978U9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

273116:TVG RS05275
gene id: 273116:TVG_RS05275
uniprot id: Q979Z9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

273116:TVG RS02920
gene id: 273116:TVG_RS02920
uniprot id: Q97BA1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

273116:TVG RS05230
gene id: 273116:TVG_RS05230
uniprot id: Q97A08
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

273116:TVG RS06990
gene id: 273116:TVG_RS06990
uniprot id: Q978T4
names: Similarity
messages: Belongs to the thioesterase PaaI family.

273116:TVG RS05515
gene id: 273116:TVG_RS05515
uniprot id: Q979V4
names: Function
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

273116:TVG RS06885
gene id: 273116:TVG_RS06885
uniprot id: Q978V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

273116:TVG RS03005
gene id: 273116:TVG_RS03005
uniprot id: Q97B85
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

273116:TVG RS07035
gene id: 273116:TVG_RS07035
uniprot id: Q978S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

273116:TVG RS02145
gene id: 273116:TVG_RS02145
uniprot id: Q97BP1
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

273116:TVG RS04540
gene id: 273116:TVG_RS04540
uniprot id: Q97AF4
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

273116:TVG RS08030
gene id: 273116:TVG_RS08030
uniprot id: Q977Z3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

273116:TVG RS00985
gene id: 273116:TVG_RS00985
uniprot id: Q97CB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

273116:TVG RS02105
gene id: 273116:TVG_RS02105
uniprot id: Q97BP9
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS02480
gene id: 273116:TVG_RS02480
uniprot id: Q97BI1
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS03275
gene id: 273116:TVG_RS03275
uniprot id: Q97B37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

273116:TVG RS01805
gene id: 273116:TVG_RS01805
uniprot id: Q97BV6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

273116:TVG RS07230
gene id: 273116:TVG_RS07230
uniprot id: Q978N8
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
messages: Cytoplasm

273116:TVG RS01640
gene id: 273116:TVG_RS01640
uniprot id: Q97BZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

273116:TVG RS06085
gene id: 273116:TVG_RS06085
uniprot id: Q979K0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

273116:TVG RS00060
gene id: 273116:TVG_RS00060
uniprot id: Q97CT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

273116:TVG RS02280
gene id: 273116:TVG_RS02280
uniprot id: Q97BL7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273116:TVG RS02530
gene id: 273116:TVG_RS02530
uniprot id: Q97BH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

273116:TVG RS00950
gene id: 273116:TVG_RS00950
uniprot id: Q97CC1
names: Similarity
messages: Belongs to the isopentenyl phosphate kinase family.

273116:TVG RS06505
gene id: 273116:TVG_RS06505
uniprot id: Q979C4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).

273116:TVG RS02140
gene id: 273116:TVG_RS02140
uniprot id: Q97BP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

273116:TVG RS05815
gene id: 273116:TVG_RS05815
uniprot id: Q979Q3
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

273116:TVG RS05895
gene id: 273116:TVG_RS05895
uniprot id: Q979N7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

273116:TVG RS05295
gene id: 273116:TVG_RS05295
uniprot id: Q979Z5
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS04840
gene id: 273116:TVG_RS04840
uniprot id: Q97A95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S41B family.
messages: Cytoplasm
messages: Part of the tricorn proteolytic complex.
messages: Tricorn degrades oligopeptides in a sequential manner.

273116:TVG RS01840
gene id: 273116:TVG_RS01840
uniprot id: Q97BU9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

273116:TVG RS06790
gene id: 273116:TVG_RS06790
uniprot id: Q977Y0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

273116:TVG RS06655
gene id: 273116:TVG_RS06655
uniprot id: Q978Z5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

273116:TVG RS01795
gene id: 273116:TVG_RS01795
uniprot id: Q97BV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

273116:TVG RS02825
gene id: 273116:TVG_RS02825
uniprot id: P58299
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

273116:TVG RS07400
gene id: 273116:TVG_RS07400
uniprot id: Q978K3
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

273116:TVG RS05485
gene id: 273116:TVG_RS05485
uniprot id: Q979W0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

273116:TVG RS05075
gene id: 273116:TVG_RS05075
uniprot id: Q97A40
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

273116:TVG RS06945
gene id: 273116:TVG_RS06945
uniprot id: Q978U3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Part of the Tricorn proteolytic complex (By similarity).
messages: Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome), yielding free amino acids.

273116:TVG RS04555
gene id: 273116:TVG_RS04555
uniprot id: Q97AF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

273116:TVG RS01635
gene id: 273116:TVG_RS01635
uniprot id: Q97BZ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

273116:TVG RS00310
gene id: 273116:TVG_RS00310
uniprot id: Q97CP2
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

273116:TVG RS04795
gene id: 273116:TVG_RS04795
uniprot id: Q97AA3
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS05330
gene id: 273116:TVG_RS05330
uniprot id: Q979Y8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

273116:TVG RS07715
gene id: 273116:TVG_RS07715
uniprot id: Q978E9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

273116:TVG RS01515
gene id: 273116:TVG_RS01515
uniprot id: Q97C13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

273116:TVG RS05065
gene id: 273116:TVG_RS05065
uniprot id: Q97A42
names: Similarity
messages: Belongs to the UPF0045 family.

273116:TVG RS03440
gene id: 273116:TVG_RS03440
uniprot id: Q97B05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

273116:TVG RS00880
gene id: 273116:TVG_RS00880
uniprot id: Q97CD5
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS02185
gene id: 273116:TVG_RS02185
uniprot id: Q97BN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

273116:TVG RS07675
gene id: 273116:TVG_RS07675
uniprot id: Q978F5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

273116:TVG RS03085
gene id: 273116:TVG_RS03085
uniprot id: Q97B72
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

273116:TVG RS01910
gene id: 273116:TVG_RS01910
uniprot id: Q97BT4
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS00850
gene id: 273116:TVG_RS00850
uniprot id: Q97CE1
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

273116:TVG RS00100
gene id: 273116:TVG_RS00100
uniprot id: Q97CT1
names: Similarity
messages: Belongs to the acylphosphatase family.

273116:TVG RS02080
gene id: 273116:TVG_RS02080
uniprot id: Q97BQ4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

273116:TVG RS00335
gene id: 273116:TVG_RS00335
uniprot id: Q97CN7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

273116:TVG RS01675
gene id: 273116:TVG_RS01675
uniprot id: Q97BY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer (By similarity).
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex (By similarity).

273116:TVG RS04435
gene id: 273116:TVG_RS04435
uniprot id: Q97AH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

273116:TVG RS06815
gene id: 273116:TVG_RS06815
uniprot id: Q978W8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

273116:TVG RS05280
gene id: 273116:TVG_RS05280
uniprot id: Q979Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

273116:TVG RS05315
gene id: 273116:TVG_RS05315
uniprot id: Q979Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

273116:TVG RS01920
gene id: 273116:TVG_RS01920
uniprot id: Q97BT2
names: Similarity
messages: Belongs to the PrpD family.

273116:TVG RS06745
gene id: 273116:TVG_RS06745
uniprot id: Q978Y1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

273116:TVG RS02565
gene id: 273116:TVG_RS02565
uniprot id: Q97BG4
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS05770
gene id: 273116:TVG_RS05770
uniprot id: Q979R0
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

273116:TVG RS06720
gene id: 273116:TVG_RS06720
uniprot id: Q978Y6
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

273116:TVG RS03515
gene id: 273116:TVG_RS03515
uniprot id: Q97AZ0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

273116:TVG RS04325
gene id: 273116:TVG_RS04325
uniprot id: Q97AJ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

273116:TVG RS05095
gene id: 273116:TVG_RS05095
uniprot id: Q97A35
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

273116:TVG RS00290
gene id: 273116:TVG_RS00290
uniprot id: Q97CP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

273116:TVG RS05335
gene id: 273116:TVG_RS05335
uniprot id: Q979Y7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

273116:TVG RS01025
gene id: 273116:TVG_RS01025
uniprot id: Q97CA6
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

273116:TVG RS01550
gene id: 273116:TVG_RS01550
uniprot id: Q97C06
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273116:TVG RS06575
gene id: 273116:TVG_RS06575
uniprot id: Q979B1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

273116:TVG RS06615
gene id: 273116:TVG_RS06615
uniprot id: Q979A3
names: Cofactor
names: Similarity
messages: Belongs to the UPF0292 family.
messages: Binds two Mg(2+) per subunit.

273116:TVG RS02360
gene id: 273116:TVG_RS02360
uniprot id: Q97BK4
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

273116:TVG RS03495
gene id: 273116:TVG_RS03495
uniprot id: Q97AZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

273116:TVG RS02645
gene id: 273116:TVG_RS02645
uniprot id: Q97BF0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

273116:TVG RS04955
gene id: 273116:TVG_RS04955
uniprot id: Q97A65
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

273116:TVG RS04305
gene id: 273116:TVG_RS04305
uniprot id: Q97AJ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Part of the tricorn proteolytic complex.
messages: Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome), yielding free amino acids.

273116:TVG RS01510
gene id: 273116:TVG_RS01510
uniprot id: Q97C14
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

273116:TVG RS00945
gene id: 273116:TVG_RS00945
uniprot id: Q97CC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

273116:TVG RS02780
gene id: 273116:TVG_RS02780
uniprot id: Q97BC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

273116:TVG RS05900
gene id: 273116:TVG_RS05900
uniprot id: Q979N6
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

273116:TVG RS00235
gene id: 273116:TVG_RS00235
uniprot id: Q97CQ6
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

273116:TVG RS00870
gene id: 273116:TVG_RS00870
uniprot id: Q97CD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

273116:TVG RS03255
gene id: 273116:TVG_RS03255
uniprot id: Q97B41
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

273116:TVG RS02890
gene id: 273116:TVG_RS02890
uniprot id: Q97BA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

273116:TVG RS05570
gene id: 273116:TVG_RS05570
uniprot id: Q979U4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

273116:TVG RS05530
gene id: 273116:TVG_RS05530
uniprot id: Q979V1
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

273116:TVG RS07245
gene id: 273116:TVG_RS07245
uniprot id: Q978N4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm

273116:TVG RS06905
gene id: 273116:TVG_RS06905
uniprot id: Q978V1
names: Similarity
messages: Belongs to the SAICAR synthetase family.

273116:TVG RS05365
gene id: 273116:TVG_RS05365
uniprot id: Q979Y2
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

273116:TVG RS01740
gene id: 273116:TVG_RS01740
uniprot id: Q97BX0
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

273116:TVG RS05030
gene id: 273116:TVG_RS05030
uniprot id: Q97A49
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
messages: Belongs to the archease family.

273116:TVG RS01610
gene id: 273116:TVG_RS01610
uniprot id: Q97BZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteromeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

273116:TVG RS05680
gene id: 273116:TVG_RS05680
uniprot id: Q979S5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

273116:TVG RS07370
gene id: 273116:TVG_RS07370
uniprot id: Q978K9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

273116:TVG RS02130
gene id: 273116:TVG_RS02130
uniprot id: Q97BP4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

273116:TVG RS07045
gene id: 273116:TVG_RS07045
uniprot id: Q978S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

273116:TVG RS02385
gene id: 273116:TVG_RS02385
uniprot id: Q97BJ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

273116:TVG RS03975
gene id: 273116:TVG_RS03975
uniprot id: Q97AR2
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

273116:TVG RS06255
gene id: 273116:TVG_RS06255
uniprot id: Q979G6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
messages: Cytoplasm
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.

273116:TVG RS05840
gene id: 273116:TVG_RS05840
uniprot id: Q979P8
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

273116:TVG RS00045
gene id: 273116:TVG_RS00045
uniprot id: Q97CU2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

273116:TVG RS05595
gene id: 273116:TVG_RS05595
uniprot id: Q979U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

273116:TVG RS04095
gene id: 273116:TVG_RS04095
uniprot id: Q97AP1
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

273116:TVG RS01075
gene id: 273116:TVG_RS01075
uniprot id: Q97C97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

273116:TVG RS03480
gene id: 273116:TVG_RS03480
uniprot id: Q97AZ7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

273116:TVG RS00340
gene id: 273116:TVG_RS00340
uniprot id: Q97CN6
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

273116:TVG RS03950
gene id: 273116:TVG_RS03950
uniprot id: Q97AR6
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS07420
gene id: 273116:TVG_RS07420
uniprot id: Q978J9
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

273116:TVG RS06705
gene id: 273116:TVG_RS06705
uniprot id: Q978Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

273116:TVG RS06535
gene id: 273116:TVG_RS06535
uniprot id: Q979B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

273116:TVG RS00990
gene id: 273116:TVG_RS00990
uniprot id: Q97CB3
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

273116:TVG RS05475
gene id: 273116:TVG_RS05475
uniprot id: Q979W2
names: Caution
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273116:TVG RS07255
gene id: 273116:TVG_RS07255
uniprot id: Q978N2
names: Similarity
messages: Belongs to the MEMO1 family.

273116:TVG RS06495
gene id: 273116:TVG_RS06495
uniprot id: Q979C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

273116:TVG RS04475
gene id: 273116:TVG_RS04475
uniprot id: Q97AG7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

273116:TVG RS03830
gene id: 273116:TVG_RS03830
uniprot id: Q97AU1
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS07380
gene id: 273116:TVG_RS07380
uniprot id: Q978K7
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

273116:TVG RS06160
gene id: 273116:TVG_RS06160
uniprot id: Q979I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

273116:TVG RS02550
gene id: 273116:TVG_RS02550
uniprot id: Q97BG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

273116:TVG RS06530
gene id: 273116:TVG_RS06530
uniprot id: Q979B9
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

273116:TVG RS01015
gene id: 273116:TVG_RS01015
uniprot id: Q97CA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

273116:TVG RS06320
gene id: 273116:TVG_RS06320
uniprot id: Q979F4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

273116:TVG RS00250
gene id: 273116:TVG_RS00250
uniprot id: Q97CQ3
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

273116:TVG RS03015
gene id: 273116:TVG_RS03015
uniprot id: Q97B83
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

273116:TVG RS03260
gene id: 273116:TVG_RS03260
uniprot id: Q97B40
names: Similarity
messages: Belongs to the phosphohexose mutase family.

273116:TVG RS02125
gene id: 273116:TVG_RS02125
uniprot id: Q97BP5
names: Similarity
messages: Belongs to the UbiD family.

273116:TVG RS02340
gene id: 273116:TVG_RS02340
uniprot id: Q97BK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

273116:TVG RS06675
gene id: 273116:TVG_RS06675
uniprot id: Q978Z2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

273116:TVG RS05165
gene id: 273116:TVG_RS05165
uniprot id: Q97A21
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

273116:TVG RS02950
gene id: 273116:TVG_RS02950
uniprot id: Q97B95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

273116:TVG RS01395
gene id: 273116:TVG_RS01395
uniprot id: Q97C36
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

273116:TVG RS06010
gene id: 273116:TVG_RS06010
uniprot id: Q979L4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.

273116:TVG RS06075
gene id: 273116:TVG_RS06075
uniprot id: Q979K2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

273116:TVG RS05955
gene id: 273116:TVG_RS05955
uniprot id: Q979M4
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS04610
gene id: 273116:TVG_RS04610
uniprot id: Q97AE0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

273116:TVG RS05300
gene id: 273116:TVG_RS05300
uniprot id: Q979Z4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

273116:TVG RS03985
gene id: 273116:TVG_RS03985
uniprot id: Q97AR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

273116:TVG RS06910
gene id: 273116:TVG_RS06910
uniprot id: Q978V0
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

273116:TVG RS05360
gene id: 273116:TVG_RS05360
uniprot id: Q979Y3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

273116:TVG RS06850
gene id: 273116:TVG_RS06850
uniprot id: Q978W1
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

273116:TVG RS02410
gene id: 273116:TVG_RS02410
uniprot id: Q97BJ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

273116:TVG RS00780
gene id: 273116:TVG_RS00780
uniprot id: Q97CF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

273116:TVG RS02180
gene id: 273116:TVG_RS02180
uniprot id: Q97BN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

273116:TVG RS03530
gene id: 273116:TVG_RS03530
uniprot id: Q97AY8
names: Similarity
messages: Belongs to the UPF0145 family.

273116:TVG RS01855
gene id: 273116:TVG_RS01855
uniprot id: Q97BU5
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

273116:TVG RS01715
gene id: 273116:TVG_RS01715
uniprot id: Q97BX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

273116:TVG RS07830
gene id: 273116:TVG_RS07830
uniprot id: Q978C7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

273116:TVG RS00040
gene id: 273116:TVG_RS00040
uniprot id: Q97CU3
names: Similarity
messages: Belongs to the PDCD5 family.

273116:TVG RS03555
gene id: 273116:TVG_RS03555
uniprot id: Q97AY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

273116:TVG RS07040
gene id: 273116:TVG_RS07040
uniprot id: Q978S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

273116:TVG RS02925
gene id: 273116:TVG_RS02925
uniprot id: Q97BA0
names: Similarity
messages: Belongs to the peptidase M24B family.

273116:TVG RS07770
gene id: 273116:TVG_RS07770
uniprot id: Q978E0
names: Cofactor
messages: Binds 1 copper ion per subunit.

273116:TVG RS04920
gene id: 273116:TVG_RS04920
uniprot id: Q97A75
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS02150
gene id: 273116:TVG_RS02150
uniprot id: Q97BP0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

273116:TVG RS07270
gene id: 273116:TVG_RS07270
uniprot id: Q978M9
names: Similarity
messages: Belongs to the peptidase S66 family.

273116:TVG RS06590
gene id: 273116:TVG_RS06590
uniprot id: Q979A8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

273116:TVG RS02345
gene id: 273116:TVG_RS02345
uniprot id: Q97BK7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

273116:TVG RS02540
gene id: 273116:TVG_RS02540
uniprot id: Q97BG9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

273116:TVG RS01370
gene id: 273116:TVG_RS01370
uniprot id: Q97C41
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

273116:TVG RS01355
gene id: 273116:TVG_RS01355
uniprot id: Q97C45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbamate kinase family.
messages: Cytoplasm

273116:TVG RS02010
gene id: 273116:TVG_RS02010
uniprot id: Q97BR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

273116:TVG RS00035
gene id: 273116:TVG_RS00035
uniprot id: Q97CU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

273116:TVG RS05305
gene id: 273116:TVG_RS05305
uniprot id: Q979Z3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

273116:TVG RS02720
gene id: 273116:TVG_RS02720
uniprot id: Q97BD7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

273116:TVG RS03980
gene id: 273116:TVG_RS03980
uniprot id: Q97AR1
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

273116:TVG RS04105
gene id: 273116:TVG_RS04105
uniprot id: Q97AN9
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

273116:TVG RS00165
gene id: 273116:TVG_RS00165
uniprot id: Q97CR8
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

273116:TVG RS06245
gene id: 273116:TVG_RS06245
uniprot id: Q979G8
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

273116:TVG RS06365
gene id: 273116:TVG_RS06365
uniprot id: Q979E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

273116:TVG RS06700
gene id: 273116:TVG_RS06700
uniprot id: Q978Y9
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

273116:TVG RS02655
gene id: 273116:TVG_RS02655
uniprot id: Q97BE8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

273116:TVG RS01810
gene id: 273116:TVG_RS01810
uniprot id: Q97BV5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

273116:TVG RS06325
gene id: 273116:TVG_RS06325
uniprot id: Q979F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

273116:TVG RS00075
gene id: 273116:TVG_RS00075
uniprot id: Q97CT6
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

273116:TVG RS05640
gene id: 273116:TVG_RS05640
uniprot id: Q979T3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

273116:TVG RS03330
gene id: 273116:TVG_RS03330
uniprot id: Q97B26
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

273116:TVG RS03315
gene id: 273116:TVG_RS03315
uniprot id: Q97B29
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

273116:TVG RS05985
gene id: 273116:TVG_RS05985
uniprot id: Q979L8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

273116:TVG RS03190
gene id: 273116:TVG_RS03190
uniprot id: Q97B53
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

273116:TVG RS03990
gene id: 273116:TVG_RS03990
uniprot id: Q97AQ9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

273116:TVG RS01725
gene id: 273116:TVG_RS01725
uniprot id: Q97BX3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

273116:TVG RS02610
gene id: 273116:TVG_RS02610
uniprot id: Q97BF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

273116:TVG RS06150
gene id: 273116:TVG_RS06150
uniprot id: Q979I7
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

273116:TVG RS06550
gene id: 273116:TVG_RS06550
uniprot id: Q979B5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

273116:TVG RS01325
gene id: 273116:TVG_RS01325
uniprot id: Q97C50
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS05510
gene id: 273116:TVG_RS05510
uniprot id: Q979V5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

273116:TVG RS05750
gene id: 273116:TVG_RS05750
uniprot id: Q979R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

273116:TVG RS03775
gene id: 273116:TVG_RS03775
uniprot id: Q97AV2
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS03435
gene id: 273116:TVG_RS03435
uniprot id: Q97B06
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS01535
gene id: 273116:TVG_RS01535
uniprot id: Q97C09
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

273116:TVG RS04180
gene id: 273116:TVG_RS04180
uniprot id: Q97AM1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

273116:TVG RS05935
gene id: 273116:TVG_RS05935
uniprot id: Q979M8
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS01985
gene id: 273116:TVG_RS01985
uniprot id: Q97BR9
names: Similarity
messages: Belongs to the AAA ATPase family.

273116:TVG RS01925
gene id: 273116:TVG_RS01925
uniprot id: Q97BT1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

273116:TVG RS05085
gene id: 273116:TVG_RS05085
uniprot id: Q97A38
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

273116:TVG RS00160
gene id: 273116:TVG_RS00160
uniprot id: Q97CR9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

273116:TVG RS01595
gene id: 273116:TVG_RS01595
uniprot id: C5J9S0
uniprot id: Q97BZ8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

273116:TVG RS02190
gene id: 273116:TVG_RS02190
uniprot id: Q97BN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

273116:TVG RS02355
gene id: 273116:TVG_RS02355
uniprot id: Q97BK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

273116:TVG RS01415
gene id: 273116:TVG_RS01415
uniprot id: Q97C32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

273116:TVG RS06545
gene id: 273116:TVG_RS06545
uniprot id: Q979B6
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS03200
gene id: 273116:TVG_RS03200
uniprot id: P57719
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.
messages: Glycosylated.

273116:TVG RS05775
gene id: 273116:TVG_RS05775
uniprot id: Q979Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

273116:TVG RS01495
gene id: 273116:TVG_RS01495
uniprot id: Q97C17
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS01835
gene id: 273116:TVG_RS01835
uniprot id: Q97BV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

273116:TVG RS05550
gene id: 273116:TVG_RS05550
uniprot id: Q979U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

273116:TVG RS07690
gene id: 273116:TVG_RS07690
uniprot id: Q978F3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PGI/PMI family.
messages: Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.
messages: Homodimer.

273116:TVG RS00925
gene id: 273116:TVG_RS00925
uniprot id: Q97CC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

273116:TVG RS06060
gene id: 273116:TVG_RS06060
uniprot id: Q979K5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.

273116:TVG RS00245
gene id: 273116:TVG_RS00245
uniprot id: Q97CQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

273116:TVG RS03165
gene id: 273116:TVG_RS03165
uniprot id: Q97B58
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.

273116:TVG RS04315
gene id: 273116:TVG_RS04315
uniprot id: Q97AJ4
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

273116:TVG RS05920
gene id: 273116:TVG_RS05920
uniprot id: Q979N2
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS05850
gene id: 273116:TVG_RS05850
uniprot id: Q979P6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.

273116:TVG RS01775
gene id: 273116:TVG_RS01775
uniprot id: Q97BW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

273116:TVG RS06970
gene id: 273116:TVG_RS06970
uniprot id: Q978T8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

273116:TVG RS02575
gene id: 273116:TVG_RS02575
uniprot id: P58274
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively (By similarity).
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity (By similarity).

273116:TVG RS05795
gene id: 273116:TVG_RS05795
uniprot id: Q979Q5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

273116:TVG RS05645
gene id: 273116:TVG_RS05645
uniprot id: Q979T2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

273116:TVG RS02815
gene id: 273116:TVG_RS02815
uniprot id: Q97BB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

273116:TVG RS01825
gene id: 273116:TVG_RS01825
uniprot id: Q97BV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

273116:TVG RS00690
gene id: 273116:TVG_RS00690
uniprot id: Q97CG9
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

273116:TVG RS06950
gene id: 273116:TVG_RS06950
uniprot id: Q978U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

273116:TVG RS05885
gene id: 273116:TVG_RS05885
uniprot id: Q979N9
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

273116:TVG RS06125
gene id: 273116:TVG_RS06125
uniprot id: Q979J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

273116:TVG RS06940
gene id: 273116:TVG_RS06940
uniprot id: Q978U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

273116:TVG RS07775
gene id: 273116:TVG_RS07775
uniprot id: Q978D9
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS00940
gene id: 273116:TVG_RS00940
uniprot id: Q97CC3
names: Similarity
messages: Belongs to the ZPR1 family.

273116:TVG RS00575
gene id: 273116:TVG_RS00575
uniprot id: Q97CJ1
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

273116:TVG RS03270
gene id: 273116:TVG_RS03270
uniprot id: Q97B38
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

273116:TVG RS00425
gene id: 273116:TVG_RS00425
uniprot id: Q97CL9
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS06825
gene id: 273116:TVG_RS06825
uniprot id: Q978W6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

273116:TVG RS00150
gene id: 273116:TVG_RS00150
uniprot id: Q97CS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.

273116:TVG RS02525
gene id: 273116:TVG_RS02525
uniprot id: Q97BH2
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

273116:TVG RS05400
gene id: 273116:TVG_RS05400
uniprot id: Q979X6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

273116:TVG RS01055
gene id: 273116:TVG_RS01055
uniprot id: Q97CA1
names: Similarity
messages: Belongs to the glutaredoxin family.

273116:TVG RS06405
gene id: 273116:TVG_RS06405
uniprot id: Q979E2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

273116:TVG RS01830
gene id: 273116:TVG_RS01830
uniprot id: Q97BV1
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS04425
gene id: 273116:TVG_RS04425
uniprot id: Q97AH7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

273116:TVG RS02070
gene id: 273116:TVG_RS02070
uniprot id: Q97BQ6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

273116:TVG RS04320
gene id: 273116:TVG_RS04320
uniprot id: Q97AJ3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

273116:TVG RS06435
gene id: 273116:TVG_RS06435
uniprot id: Q979D7
names: Similarity
messages: Belongs to the peptidase S45 family.

273116:TVG RS01710
gene id: 273116:TVG_RS01710
uniprot id: Q97BX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

273116:TVG RS00355
gene id: 273116:TVG_RS00355
uniprot id: Q97CN3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

273116:TVG RS04960
gene id: 273116:TVG_RS04960
uniprot id: Q97A64
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

273116:TVG RS05830
gene id: 273116:TVG_RS05830
uniprot id: Q979Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

273116:TVG RS06380
gene id: 273116:TVG_RS06380
uniprot id: Q979E4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

273116:TVG RS00500
gene id: 273116:TVG_RS00500
uniprot id: Q97CK6
names: Similarity
messages: Belongs to the ComB family.

273116:TVG RS04575
gene id: 273116:TVG_RS04575
uniprot id: Q97AE7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

273116:TVG RS03825
gene id: 273116:TVG_RS03825
uniprot id: Q97AU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

273116:TVG RS00080
gene id: 273116:TVG_RS00080
uniprot id: Q97CT5
names: Similarity
messages: Belongs to the PurH family.

273116:TVG RS05675
gene id: 273116:TVG_RS05675
uniprot id: Q979S6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

273116:TVG RS03080
gene id: 273116:TVG_RS03080
uniprot id: Q97B73
names: Similarity
messages: Belongs to the CinA family.

273116:TVG RS04465
gene id: 273116:TVG_RS04465
uniprot id: Q97AG9
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.

273116:TVG RS04340
gene id: 273116:TVG_RS04340
uniprot id: Q97AI9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

273116:TVG RS00620
gene id: 273116:TVG_RS00620
uniprot id: Q97CI4
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

273116:TVG RS02665
gene id: 273116:TVG_RS02665
uniprot id: Q97BE6
names: Subcellular Location Annotation
messages: Membrane

273116:TVG RS00995
gene id: 273116:TVG_RS00995
uniprot id: Q97CB2
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

273116:TVG RS03610
gene id: 273116:TVG_RS03610
uniprot id: Q97AX4
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

273116:TVG RS03320
gene id: 273116:TVG_RS03320
uniprot id: Q97B28
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

273116:TVG RS05020
gene id: 273116:TVG_RS05020
uniprot id: Q97A51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

273116:TVG RS01815
gene id: 273116:TVG_RS01815
uniprot id: Q97BV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

273116:TVG RS04910
gene id: 273116:TVG_RS04910
uniprot id: Q97A78
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

273116:TVG RS06635
gene id: 273116:TVG_RS06635
uniprot id: Q978Z9
names: Similarity
messages: Belongs to the AOR/FOR family.

273116:TVG RS07805
gene id: 273116:TVG_RS07805
uniprot id: Q978D2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

273116:TVG RS05500
gene id: 273116:TVG_RS05500
uniprot id: Q979V7
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

273116:TVG RS01090
gene id: 273116:TVG_RS01090
uniprot id: Q97C94
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.