268739:NMLP RS10570
gene id: 268739:NMLP_RS10570
uniprot id: M1XSL3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS05825
gene id: 268739:NMLP_RS05825
uniprot id: M1XKR9
names: Similarity
messages: Belongs to the PDCD5 family.

268739:NMLP RS12780
gene id: 268739:NMLP_RS12780
uniprot id: M1XLJ2
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

268739:NMLP RS03995
gene id: 268739:NMLP_RS03995
uniprot id: M1XKJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

268739:NMLP RS05225
gene id: 268739:NMLP_RS05225
uniprot id: M1Y1B8
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS01110
gene id: 268739:NMLP_RS01110
uniprot id: M1XK83
names: Subcellular Location Annotation
messages: Cell membrane

268739:NMLP RS09000
gene id: 268739:NMLP_RS09000
uniprot id: M1XRZ9
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

268739:NMLP RS05435
gene id: 268739:NMLP_RS05435
uniprot id: M1Y1G1
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS00640
gene id: 268739:NMLP_RS00640
uniprot id: M1XN59
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

268739:NMLP RS05210
gene id: 268739:NMLP_RS05210
uniprot id: M1XQ72
names: Similarity
messages: Belongs to the SCO1/2 family.

268739:NMLP RS06430
gene id: 268739:NMLP_RS06430
uniprot id: M1XQW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

268739:NMLP RS08170
gene id: 268739:NMLP_RS08170
uniprot id: M1XRM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

268739:NMLP RS04790
gene id: 268739:NMLP_RS04790
uniprot id: M1XPZ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

268739:NMLP RS04980
gene id: 268739:NMLP_RS04980
uniprot id: M1XQ40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
messages: Tetramer of two components I and two components II.

268739:NMLP RS10030
gene id: 268739:NMLP_RS10030
uniprot id: M1XSE7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

268739:NMLP RS06710
gene id: 268739:NMLP_RS06710
uniprot id: M1XQX0
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS04710
gene id: 268739:NMLP_RS04710
uniprot id: M1XPY9
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

268739:NMLP RS08795
gene id: 268739:NMLP_RS08795
uniprot id: M1XRU2
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

268739:NMLP RS00065
gene id: 268739:NMLP_RS00065
uniprot id: M1XMY4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

268739:NMLP RS12225
gene id: 268739:NMLP_RS12225
uniprot id: M1XTC8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

268739:NMLP RS01825
gene id: 268739:NMLP_RS01825
uniprot id: M1XNQ1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS09485
gene id: 268739:NMLP_RS09485
uniprot id: M1XL61
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

268739:NMLP RS09880
gene id: 268739:NMLP_RS09880
uniprot id: M1Y3W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

268739:NMLP RS03890
gene id: 268739:NMLP_RS03890
uniprot id: M1XPL6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

268739:NMLP RS13560
gene id: 268739:NMLP_RS13560
uniprot id: M1XTV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

268739:NMLP RS08755
gene id: 268739:NMLP_RS08755
uniprot id: M1XRW0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS01570
gene id: 268739:NMLP_RS01570
uniprot id: M1XNL6
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

268739:NMLP RS08285
gene id: 268739:NMLP_RS08285
uniprot id: M1XRN4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

268739:NMLP RS06910
gene id: 268739:NMLP_RS06910
uniprot id: M1XQZ7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

268739:NMLP RS11585
gene id: 268739:NMLP_RS11585
uniprot id: M1XT34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

268739:NMLP RS06455
gene id: 268739:NMLP_RS06455
uniprot id: M1XQW8
names: Similarity
messages: Belongs to the eIF-2-alpha family.

268739:NMLP RS12775
gene id: 268739:NMLP_RS12775
uniprot id: M1XTI2
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 zinc ion.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

268739:NMLP RS13105
gene id: 268739:NMLP_RS13105
uniprot id: M1XTN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

268739:NMLP RS02375
gene id: 268739:NMLP_RS02375
uniprot id: M1XNW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

268739:NMLP RS00565
gene id: 268739:NMLP_RS00565
uniprot id: M1XN47
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

268739:NMLP RS13400
gene id: 268739:NMLP_RS13400
uniprot id: M1XU14
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS06840
gene id: 268739:NMLP_RS06840
uniprot id: M1XQZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

268739:NMLP RS05425
gene id: 268739:NMLP_RS05425
uniprot id: M1XKQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

268739:NMLP RS10930
gene id: 268739:NMLP_RS10930
uniprot id: M1XSS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

268739:NMLP RS04855
gene id: 268739:NMLP_RS04855
uniprot id: M1XQ20
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

268739:NMLP RS01025
gene id: 268739:NMLP_RS01025
uniprot id: M1XNE1
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS12300
gene id: 268739:NMLP_RS12300
uniprot id: M1Y582
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

268739:NMLP RS11855
gene id: 268739:NMLP_RS11855
uniprot id: M1XT73
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS02225
gene id: 268739:NMLP_RS02225
uniprot id: M1XZP6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS10440
gene id: 268739:NMLP_RS10440
uniprot id: M1XSI5
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

268739:NMLP RS03300
gene id: 268739:NMLP_RS03300
uniprot id: M1XPA9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

268739:NMLP RS06885
gene id: 268739:NMLP_RS06885
uniprot id: M1Y297
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

268739:NMLP RS11535
gene id: 268739:NMLP_RS11535
uniprot id: M1XT30
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS12320
gene id: 268739:NMLP_RS12320
uniprot id: M1XTE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
messages: Cell membrane
messages: Forms a complex with DabB.
messages: Part of an energy-coupled inorganic carbon pump.

268739:NMLP RS04005
gene id: 268739:NMLP_RS04005
uniprot id: M1Y0N0
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

268739:NMLP RS03375
gene id: 268739:NMLP_RS03375
uniprot id: M1XPD5
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

268739:NMLP RS11370
gene id: 268739:NMLP_RS11370
uniprot id: M1XSY9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

268739:NMLP RS00385
gene id: 268739:NMLP_RS00385
uniprot id: M1XYS9
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS02905
gene id: 268739:NMLP_RS02905
uniprot id: M1Y028
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

268739:NMLP RS00120
gene id: 268739:NMLP_RS00120
uniprot id: M1XMY0
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

268739:NMLP RS05245
gene id: 268739:NMLP_RS05245
uniprot id: M1XQ82
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

268739:NMLP RS00570
gene id: 268739:NMLP_RS00570
uniprot id: M1XYW0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS13525
gene id: 268739:NMLP_RS13525
uniprot id: M1Y5X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

268739:NMLP RS06510
gene id: 268739:NMLP_RS06510
uniprot id: M1XKU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

268739:NMLP RS02975
gene id: 268739:NMLP_RS02975
uniprot id: M1XP72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

268739:NMLP RS12745
gene id: 268739:NMLP_RS12745
uniprot id: M1Y5G5
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS06290
gene id: 268739:NMLP_RS06290
uniprot id: M1XQQ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS06895
gene id: 268739:NMLP_RS06895
uniprot id: M1XR03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

268739:NMLP RS03240
gene id: 268739:NMLP_RS03240
uniprot id: M1Y090
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

268739:NMLP RS03160
gene id: 268739:NMLP_RS03160
uniprot id: M1XPA3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

268739:NMLP RS12120
gene id: 268739:NMLP_RS12120
uniprot id: M1XTA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

268739:NMLP RS06750
gene id: 268739:NMLP_RS06750
uniprot id: M1Y276
names: Similarity
messages: Belongs to the peptidase C56 family.

268739:NMLP RS13750
gene id: 268739:NMLP_RS13750
uniprot id: M1XU25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

268739:NMLP RS06630
gene id: 268739:NMLP_RS06630
uniprot id: M1XQV8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

268739:NMLP RS07015
gene id: 268739:NMLP_RS07015
uniprot id: M1Y2C0
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS00450
gene id: 268739:NMLP_RS00450
uniprot id: M1XK57
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

268739:NMLP RS02700
gene id: 268739:NMLP_RS02700
uniprot id: M1XKE5
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

268739:NMLP RS01155
gene id: 268739:NMLP_RS01155
uniprot id: M1XNE4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

268739:NMLP RS06200
gene id: 268739:NMLP_RS06200
uniprot id: M1Y1X3
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

268739:NMLP RS02400
gene id: 268739:NMLP_RS02400
uniprot id: M1XNX0
names: Similarity
messages: Belongs to the arginase family.

268739:NMLP RS06050
gene id: 268739:NMLP_RS06050
uniprot id: M1XQJ3
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS10575
gene id: 268739:NMLP_RS10575
uniprot id: M1Y4B4
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS11350
gene id: 268739:NMLP_RS11350
uniprot id: M1XSZ2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

268739:NMLP RS12290
gene id: 268739:NMLP_RS12290
uniprot id: M1XLH2
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

268739:NMLP RS01015
gene id: 268739:NMLP_RS01015
uniprot id: M1XNB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

268739:NMLP RS13100
gene id: 268739:NMLP_RS13100
uniprot id: M1XTV8
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

268739:NMLP RS08860
gene id: 268739:NMLP_RS08860
uniprot id: M1Y3C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

268739:NMLP RS06395
gene id: 268739:NMLP_RS06395
uniprot id: M1XQR8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS08645
gene id: 268739:NMLP_RS08645
uniprot id: M1XL29
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS07060
gene id: 268739:NMLP_RS07060
uniprot id: M1XR20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADH dehydrogenase family.
messages: Cytoplasm

268739:NMLP RS05340
gene id: 268739:NMLP_RS05340
uniprot id: M1XQ92
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

268739:NMLP RS12280
gene id: 268739:NMLP_RS12280
uniprot id: M1XTG4
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

268739:NMLP RS01820
gene id: 268739:NMLP_RS01820
uniprot id: M1XKB1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

268739:NMLP RS05130
gene id: 268739:NMLP_RS05130
uniprot id: M1XQ59
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

268739:NMLP RS01480
gene id: 268739:NMLP_RS01480
uniprot id: M1XNL0
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

268739:NMLP RS12355
gene id: 268739:NMLP_RS12355
uniprot id: M1XTH3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

268739:NMLP RS13905
gene id: 268739:NMLP_RS13905
uniprot id: M1Y654
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

268739:NMLP RS08325
gene id: 268739:NMLP_RS08325
uniprot id: M1XRQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

268739:NMLP RS00880
gene id: 268739:NMLP_RS00880
uniprot id: M1XN99
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

268739:NMLP RS05190
gene id: 268739:NMLP_RS05190
uniprot id: M1XKP4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

268739:NMLP RS01205
gene id: 268739:NMLP_RS01205
uniprot id: M1XNF2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS06420
gene id: 268739:NMLP_RS06420
uniprot id: M1XQS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

268739:NMLP RS09445
gene id: 268739:NMLP_RS09445
uniprot id: M1Y3N4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

268739:NMLP RS06210
gene id: 268739:NMLP_RS06210
uniprot id: M1XQM1
names: Similarity
messages: Belongs to the cytochrome P450 family.

268739:NMLP RS11050
gene id: 268739:NMLP_RS11050
uniprot id: M1Y4K7
names: Similarity
messages: Belongs to the UPF0179 family.

268739:NMLP RS05025
gene id: 268739:NMLP_RS05025
uniprot id: M1XQ77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

268739:NMLP RS08805
gene id: 268739:NMLP_RS08805
uniprot id: M1XRW6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

268739:NMLP RS12725
gene id: 268739:NMLP_RS12725
uniprot id: M1Y5G0
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

268739:NMLP RS02885
gene id: 268739:NMLP_RS02885
uniprot id: M1XP79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

268739:NMLP RS09660
gene id: 268739:NMLP_RS09660
uniprot id: M1XS99
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

268739:NMLP RS08225
gene id: 268739:NMLP_RS08225
uniprot id: M1XRJ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

268739:NMLP RS07760
gene id: 268739:NMLP_RS07760
uniprot id: M1XRE7
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS05395
gene id: 268739:NMLP_RS05395
uniprot id: M1XQ99
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS03760
gene id: 268739:NMLP_RS03760
uniprot id: M1XPP5
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

268739:NMLP RS02710
gene id: 268739:NMLP_RS02710
uniprot id: M1XZY9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

268739:NMLP RS11650
gene id: 268739:NMLP_RS11650
uniprot id: M1XT45
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

268739:NMLP RS02845
gene id: 268739:NMLP_RS02845
uniprot id: M1XP36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

268739:NMLP RS13430
gene id: 268739:NMLP_RS13430
uniprot id: M1XU18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

268739:NMLP RS10045
gene id: 268739:NMLP_RS10045
uniprot id: M1XL83
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS06615
gene id: 268739:NMLP_RS06615
uniprot id: M1Y256
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

268739:NMLP RS00845
gene id: 268739:NMLP_RS00845
uniprot id: M1XZ11
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS11750
gene id: 268739:NMLP_RS11750
uniprot id: M1XLF0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS04600
gene id: 268739:NMLP_RS04600
uniprot id: M1XPX4
names: Similarity
messages: Belongs to the HepT RNase toxin family.

268739:NMLP RS02570
gene id: 268739:NMLP_RS02570
uniprot id: M1XNZ7
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS12880
gene id: 268739:NMLP_RS12880
uniprot id: M1XTJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

268739:NMLP RS04405
gene id: 268739:NMLP_RS04405
uniprot id: M1XPU4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS07785
gene id: 268739:NMLP_RS07785
uniprot id: M1XRF2
names: Similarity
messages: Belongs to the UPF0175 family.

268739:NMLP RS12175
gene id: 268739:NMLP_RS12175
uniprot id: M1XTB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

268739:NMLP RS09595
gene id: 268739:NMLP_RS09595
uniprot id: M1XL65
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

268739:NMLP RS05780
gene id: 268739:NMLP_RS05780
uniprot id: M1XQI2
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

268739:NMLP RS04410
gene id: 268739:NMLP_RS04410
uniprot id: M1XKL4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS03920
gene id: 268739:NMLP_RS03920
uniprot id: M1XKJ4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

268739:NMLP RS07100
gene id: 268739:NMLP_RS07100
uniprot id: M1XR23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

268739:NMLP RS00865
gene id: 268739:NMLP_RS00865
uniprot id: M1XN93
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS12285
gene id: 268739:NMLP_RS12285
uniprot id: M1XTD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

268739:NMLP RS11615
gene id: 268739:NMLP_RS11615
uniprot id: M1Y4W9
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

268739:NMLP RS00675
gene id: 268739:NMLP_RS00675
uniprot id: M1XN81
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

268739:NMLP RS04690
gene id: 268739:NMLP_RS04690
uniprot id: M1XPZ9
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

268739:NMLP RS10635
gene id: 268739:NMLP_RS10635
uniprot id: M1XSL9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

268739:NMLP RS02970
gene id: 268739:NMLP_RS02970
uniprot id: M1XKF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

268739:NMLP RS01975
gene id: 268739:NMLP_RS01975
uniprot id: M1XNS7
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

268739:NMLP RS03655
gene id: 268739:NMLP_RS03655
uniprot id: M1Y0H3
names: Function
names: Subcellular Location Annotation
messages: May play a structural or regulatory role in gas vesicle synthesis.
messages: Vesicle
messages: gas vesicle

268739:NMLP RS05725
gene id: 268739:NMLP_RS05725
uniprot id: M1XQK1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

268739:NMLP RS02880
gene id: 268739:NMLP_RS02880
uniprot id: M1Y023
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

268739:NMLP RS10670
gene id: 268739:NMLP_RS10670
uniprot id: M1XLA8
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

268739:NMLP RS00210
gene id: 268739:NMLP_RS00210
uniprot id: M1XMY1
names: Similarity
messages: Belongs to the UPF0284 family.

268739:NMLP RS13830
gene id: 268739:NMLP_RS13830
uniprot id: M1Y643
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

268739:NMLP RS03845
gene id: 268739:NMLP_RS03845
uniprot id: M1Y0K5
names: Similarity
messages: Belongs to the threonine synthase family.

268739:NMLP RS00180
gene id: 268739:NMLP_RS00180
uniprot id: M1XK46
names: Similarity
messages: Belongs to the aspartokinase family.

268739:NMLP RS11705
gene id: 268739:NMLP_RS11705
uniprot id: M1XLE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

268739:NMLP RS01065
gene id: 268739:NMLP_RS01065
uniprot id: M1XNC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

268739:NMLP RS01545
gene id: 268739:NMLP_RS01545
uniprot id: M1XNK7
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

268739:NMLP RS11580
gene id: 268739:NMLP_RS11580
uniprot id: M1XLE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

268739:NMLP RS03685
gene id: 268739:NMLP_RS03685
uniprot id: M1XPH1
names: Similarity
messages: Belongs to the gas vesicle protein type A family.

268739:NMLP RS05330
gene id: 268739:NMLP_RS05330
uniprot id: M1Y1D8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS07430
gene id: 268739:NMLP_RS07430
uniprot id: M1XKY1
names: Similarity
messages: Belongs to the SELO family.

268739:NMLP RS12410
gene id: 268739:NMLP_RS12410
uniprot id: M1XTH9
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS08020
gene id: 268739:NMLP_RS08020
uniprot id: M1Y2V0
names: Function
names: Subunit
messages: Interacts with chemotaxis (Che) proteins as well as flagella accessory (Fla) proteins.
messages: Involved in taxis signal transduction.

268739:NMLP RS06550
gene id: 268739:NMLP_RS06550
uniprot id: M1XQY6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

268739:NMLP RS01970
gene id: 268739:NMLP_RS01970
uniprot id: M1XZK5
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

268739:NMLP RS11525
gene id: 268739:NMLP_RS11525
uniprot id: M1XT29
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS10330
gene id: 268739:NMLP_RS10330
uniprot id: M1XSG3
names: Similarity
messages: Belongs to the UPF0173 family.

268739:NMLP RS02055
gene id: 268739:NMLP_RS02055
uniprot id: M1XNU4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

268739:NMLP RS14550
gene id: 268739:NMLP_RS14550
uniprot id: M1Y496
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

268739:NMLP RS05575
gene id: 268739:NMLP_RS05575
uniprot id: M1XKQ9
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

268739:NMLP RS13480
gene id: 268739:NMLP_RS13480
uniprot id: M1XU26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

268739:NMLP RS06725
gene id: 268739:NMLP_RS06725
uniprot id: M1Y272
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 3 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

268739:NMLP RS00980
gene id: 268739:NMLP_RS00980
uniprot id: M1XNB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

268739:NMLP RS12595
gene id: 268739:NMLP_RS12595
uniprot id: M1Y5D7
names: Similarity
messages: Belongs to the AOR/FOR family.

268739:NMLP RS03815
gene id: 268739:NMLP_RS03815
uniprot id: M1XPQ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

268739:NMLP RS12945
gene id: 268739:NMLP_RS12945
uniprot id: M1Y5K3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

268739:NMLP RS02065
gene id: 268739:NMLP_RS02065
uniprot id: M1XKC0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

268739:NMLP RS13190
gene id: 268739:NMLP_RS13190
uniprot id: M1XTT0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

268739:NMLP RS13365
gene id: 268739:NMLP_RS13365
uniprot id: M1XTV9
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

268739:NMLP RS03720
gene id: 268739:NMLP_RS03720
uniprot id: M1XKI6
names: Similarity
messages: Belongs to the archease family.

268739:NMLP RS04795
gene id: 268739:NMLP_RS04795
uniprot id: M1XKM9
names: Similarity
messages: Belongs to the anthranilate synthase component I family.
messages: Belongs to the isochorismate synthase family.

268739:NMLP RS00310
gene id: 268739:NMLP_RS00310
uniprot id: M1XMZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

268739:NMLP RS06385
gene id: 268739:NMLP_RS06385
uniprot id: M1XQS2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

268739:NMLP RS10615
gene id: 268739:NMLP_RS10615
uniprot id: M1XLA6
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

268739:NMLP RS02930
gene id: 268739:NMLP_RS02930
uniprot id: M1Y033
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

268739:NMLP RS01190
gene id: 268739:NMLP_RS01190
uniprot id: M1XND9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

268739:NMLP RS11315
gene id: 268739:NMLP_RS11315
uniprot id: M1XLD3
names: Similarity
messages: Belongs to the PrpD family.

268739:NMLP RS10350
gene id: 268739:NMLP_RS10350
uniprot id: M1XSJ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

268739:NMLP RS06305
gene id: 268739:NMLP_RS06305
uniprot id: M1XQP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

268739:NMLP RS04275
gene id: 268739:NMLP_RS04275
uniprot id: M1XPT8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

268739:NMLP RS01280
gene id: 268739:NMLP_RS01280
uniprot id: M1XNG5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

268739:NMLP RS01235
gene id: 268739:NMLP_RS01235
uniprot id: M1XK88
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS11870
gene id: 268739:NMLP_RS11870
uniprot id: M1Y508
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

268739:NMLP RS01370
gene id: 268739:NMLP_RS01370
uniprot id: M1XNH7
names: Similarity
messages: Belongs to the TBP family.

268739:NMLP RS09770
gene id: 268739:NMLP_RS09770
uniprot id: M1XL72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

268739:NMLP RS12245
gene id: 268739:NMLP_RS12245
uniprot id: M1XLH0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Brp/Blh beta-carotene diooxygenase family.
messages: Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS02955
gene id: 268739:NMLP_RS02955
uniprot id: M1Y038
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

268739:NMLP RS00770
gene id: 268739:NMLP_RS00770
uniprot id: M1XYZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

268739:NMLP RS06870
gene id: 268739:NMLP_RS06870
uniprot id: M1XKW0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

268739:NMLP RS12585
gene id: 268739:NMLP_RS12585
uniprot id: M1XLI4
names: Similarity
messages: Belongs to the AOR/FOR family.

268739:NMLP RS09430
gene id: 268739:NMLP_RS09430
uniprot id: M1XS37
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS01210
gene id: 268739:NMLP_RS01210
uniprot id: M1XK87
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

268739:NMLP RS13600
gene id: 268739:NMLP_RS13600
uniprot id: M1XU44
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

268739:NMLP RS02805
gene id: 268739:NMLP_RS02805
uniprot id: M1XP41
names: Similarity
messages: Belongs to the AOR/FOR family.

268739:NMLP RS13340
gene id: 268739:NMLP_RS13340
uniprot id: M1XTV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

268739:NMLP RS08290
gene id: 268739:NMLP_RS08290
uniprot id: M1Y319
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

268739:NMLP RS01660
gene id: 268739:NMLP_RS01660
uniprot id: M1XNN8
names: Similarity
messages: Belongs to the SAICAR synthetase family.

268739:NMLP RS04260
gene id: 268739:NMLP_RS04260
uniprot id: M1XPW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

268739:NMLP RS08205
gene id: 268739:NMLP_RS08205
uniprot id: M1XL12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

268739:NMLP RS02050
gene id: 268739:NMLP_RS02050
uniprot id: M1XZL7
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

268739:NMLP RS10610
gene id: 268739:NMLP_RS10610
uniprot id: M1XSL4
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

268739:NMLP RS01475
gene id: 268739:NMLP_RS01475
uniprot id: M1XZB8
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

268739:NMLP RS01055
gene id: 268739:NMLP_RS01055
uniprot id: M1XND0
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS01005
gene id: 268739:NMLP_RS01005
uniprot id: M1XNB9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS08295
gene id: 268739:NMLP_RS08295
uniprot id: M1XRP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

268739:NMLP RS04075
gene id: 268739:NMLP_RS04075
uniprot id: M1Y0P2
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

268739:NMLP RS04130
gene id: 268739:NMLP_RS04130
uniprot id: M1Y0Q0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

268739:NMLP RS13355
gene id: 268739:NMLP_RS13355
uniprot id: M1XTS3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

268739:NMLP RS05285
gene id: 268739:NMLP_RS05285
uniprot id: M1XQC9
names: Function
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: May catalyze a purine salvage reaction, the substrate is unknown.

268739:NMLP RS03460
gene id: 268739:NMLP_RS03460
uniprot id: M1XPJ5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

268739:NMLP RS12855
gene id: 268739:NMLP_RS12855
uniprot id: M1XTJ3
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

268739:NMLP RS11665
gene id: 268739:NMLP_RS11665
uniprot id: M1Y4X6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS10105
gene id: 268739:NMLP_RS10105
uniprot id: M1XSC8
names: Function
messages: Part of a potassium transport system.

268739:NMLP RS02940
gene id: 268739:NMLP_RS02940
uniprot id: M1XP54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

268739:NMLP RS01935
gene id: 268739:NMLP_RS01935
uniprot id: M1XNQ2
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

268739:NMLP RS08695
gene id: 268739:NMLP_RS08695
uniprot id: M1XL31
names: Similarity
messages: Belongs to the GARS family.

268739:NMLP RS09760
gene id: 268739:NMLP_RS09760
uniprot id: M1XSB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

268739:NMLP RS06990
gene id: 268739:NMLP_RS06990
uniprot id: M1Y2B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

268739:NMLP RS04530
gene id: 268739:NMLP_RS04530
uniprot id: M1XPW2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

268739:NMLP RS00355
gene id: 268739:NMLP_RS00355
uniprot id: M1XK53
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS08315
gene id: 268739:NMLP_RS08315
uniprot id: M1XRN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

268739:NMLP RS10940
gene id: 268739:NMLP_RS10940
uniprot id: M1XSU8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

268739:NMLP RS10180
gene id: 268739:NMLP_RS10180
uniprot id: M1XL88
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS11520
gene id: 268739:NMLP_RS11520
uniprot id: M1XT42
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS02085
gene id: 268739:NMLP_RS02085
uniprot id: M1XNS3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

268739:NMLP RS02295
gene id: 268739:NMLP_RS02295
uniprot id: M1XNV2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

268739:NMLP RS00680
gene id: 268739:NMLP_RS00680
uniprot id: M1XN68
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS09890
gene id: 268739:NMLP_RS09890
uniprot id: M1XS98
names: Subcellular Location Annotation
messages: Cytoplasm

268739:NMLP RS05910
gene id: 268739:NMLP_RS05910
uniprot id: M1XQJ5
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

268739:NMLP RS13910
gene id: 268739:NMLP_RS13910
uniprot id: M1XU74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

268739:NMLP RS11755
gene id: 268739:NMLP_RS11755
uniprot id: M1XT55
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS10290
gene id: 268739:NMLP_RS10290
uniprot id: M1XSF7
names: Similarity
messages: Belongs to the acetolactate synthase small subunit family.

268739:NMLP RS04990
gene id: 268739:NMLP_RS04990
uniprot id: M1XQ73
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS13890
gene id: 268739:NMLP_RS13890
uniprot id: M1XU08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

268739:NMLP RS04860
gene id: 268739:NMLP_RS04860
uniprot id: M1Y134
names: Similarity
messages: Belongs to the arginase family.

268739:NMLP RS08955
gene id: 268739:NMLP_RS08955
uniprot id: M1Y3F9
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS11375
gene id: 268739:NMLP_RS11375
uniprot id: M1XLD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

268739:NMLP RS06065
gene id: 268739:NMLP_RS06065
uniprot id: M1Y1U6
names: Function
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
messages: Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC), the main low-molecular-weight thiol compound instead of glutathione in halophilic archaea.

268739:NMLP RS01595
gene id: 268739:NMLP_RS01595
uniprot id: M1XKA2
names: Subcellular Location Annotation
messages: Cytoplasm

268739:NMLP RS02725
gene id: 268739:NMLP_RS02725
uniprot id: M1XKE6
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

268739:NMLP RS02590
gene id: 268739:NMLP_RS02590
uniprot id: M1XKE1
names: Subcellular Location Annotation
messages: Cytoplasm

268739:NMLP RS11640
gene id: 268739:NMLP_RS11640
uniprot id: M1Y4X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

268739:NMLP RS05430
gene id: 268739:NMLP_RS05430
uniprot id: M1XQB6
names: Similarity
messages: Belongs to the IMPACT family.

268739:NMLP RS11745
gene id: 268739:NMLP_RS11745
uniprot id: M1XT60
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS12890
gene id: 268739:NMLP_RS12890
uniprot id: M1XTM5
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

268739:NMLP RS07105
gene id: 268739:NMLP_RS07105
uniprot id: M1XKW9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

268739:NMLP RS01100
gene id: 268739:NMLP_RS01100
uniprot id: M1XNF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

268739:NMLP RS05115
gene id: 268739:NMLP_RS05115
uniprot id: M1XQ60
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

268739:NMLP RS00795
gene id: 268739:NMLP_RS00795
uniprot id: M1XZ02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

268739:NMLP RS09525
gene id: 268739:NMLP_RS09525
uniprot id: M1Y3P7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

268739:NMLP RS03350
gene id: 268739:NMLP_RS03350
uniprot id: M1XPD3
names: Similarity
messages: Belongs to the DtxR/MntR family.

268739:NMLP RS11880
gene id: 268739:NMLP_RS11880
uniprot id: M1XT77
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

268739:NMLP RS02455
gene id: 268739:NMLP_RS02455
uniprot id: M1XZU1
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.

268739:NMLP RS10725
gene id: 268739:NMLP_RS10725
uniprot id: M1XSP2
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

268739:NMLP RS07120
gene id: 268739:NMLP_RS07120
uniprot id: M1Y2E0
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

268739:NMLP RS01650
gene id: 268739:NMLP_RS01650
uniprot id: M1XNN0
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

268739:NMLP RS06545
gene id: 268739:NMLP_RS06545
uniprot id: M1Y245
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

268739:NMLP RS07860
gene id: 268739:NMLP_RS07860
uniprot id: M1XRG5
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

268739:NMLP RS11865
gene id: 268739:NMLP_RS11865
uniprot id: M1XT68
names: Similarity
messages: Belongs to the HMBS family.

268739:NMLP RS00090
gene id: 268739:NMLP_RS00090
uniprot id: M1XMY8
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

268739:NMLP RS04575
gene id: 268739:NMLP_RS04575
uniprot id: M1XQ14
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

268739:NMLP RS08215
gene id: 268739:NMLP_RS08215
uniprot id: M1Y2Z0
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

268739:NMLP RS05770
gene id: 268739:NMLP_RS05770
uniprot id: M1XKR7
names: Similarity
messages: Belongs to the UPF0047 family.

268739:NMLP RS03230
gene id: 268739:NMLP_RS03230
uniprot id: M1XKG6
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS12955
gene id: 268739:NMLP_RS12955
uniprot id: M1XTK8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS09850
gene id: 268739:NMLP_RS09850
uniprot id: M1XS94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

268739:NMLP RS11380
gene id: 268739:NMLP_RS11380
uniprot id: M1XSZ7
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS00070
gene id: 268739:NMLP_RS00070
uniprot id: M1XMX4
names: Similarity
messages: Belongs to the UPF0146 family.

268739:NMLP RS00585
gene id: 268739:NMLP_RS00585
uniprot id: M1XK62
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

268739:NMLP RS02300
gene id: 268739:NMLP_RS02300
uniprot id: M1XKC9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

268739:NMLP RS03180
gene id: 268739:NMLP_RS03180
uniprot id: M1XKG4
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

268739:NMLP RS10780
gene id: 268739:NMLP_RS10780
uniprot id: M1Y4F4
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS07145
gene id: 268739:NMLP_RS07145
uniprot id: M1Y2E5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

268739:NMLP RS12735
gene id: 268739:NMLP_RS12735
uniprot id: M1XLJ0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

268739:NMLP RS06645
gene id: 268739:NMLP_RS06645
uniprot id: M1Y260
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

268739:NMLP RS05535
gene id: 268739:NMLP_RS05535
uniprot id: M1Y1I2
names: Similarity
messages: Belongs to the thymidylate kinase family.

268739:NMLP RS09450
gene id: 268739:NMLP_RS09450
uniprot id: M1XS71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

268739:NMLP RS12915
gene id: 268739:NMLP_RS12915
uniprot id: M1XTN0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

268739:NMLP RS05205
gene id: 268739:NMLP_RS05205
uniprot id: M1XQB2
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS08275
gene id: 268739:NMLP_RS08275
uniprot id: M1XRK5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

268739:NMLP RS03275
gene id: 268739:NMLP_RS03275
uniprot id: M1XPA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

268739:NMLP RS06745
gene id: 268739:NMLP_RS06745
uniprot id: M1XQX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

268739:NMLP RS12925
gene id: 268739:NMLP_RS12925
uniprot id: M1XTS6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS01295
gene id: 268739:NMLP_RS01295
uniprot id: M1XZ95
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

268739:NMLP RS13120
gene id: 268739:NMLP_RS13120
uniprot id: M1Y5N7
names: Similarity
messages: Belongs to the UPF0440 family.

268739:NMLP RS01815
gene id: 268739:NMLP_RS01815
uniprot id: M1XNN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

268739:NMLP RS04155
gene id: 268739:NMLP_RS04155
uniprot id: M1Y0Q5
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

268739:NMLP RS13505
gene id: 268739:NMLP_RS13505
uniprot id: M1XU29
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

268739:NMLP RS02870
gene id: 268739:NMLP_RS02870
uniprot id: M1XKF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

268739:NMLP RS09865
gene id: 268739:NMLP_RS09865
uniprot id: M1XS96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

268739:NMLP RS04540
gene id: 268739:NMLP_RS04540
uniprot id: M1XPY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

268739:NMLP RS07050
gene id: 268739:NMLP_RS07050
uniprot id: M1XR18
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

268739:NMLP RS06555
gene id: 268739:NMLP_RS06555
uniprot id: M1XQU8
names: Similarity
messages: Belongs to the SDO1/SBDS family.

268739:NMLP RS03265
gene id: 268739:NMLP_RS03265
uniprot id: M1Y097
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for chromosome condensation and partitioning.

268739:NMLP RS04630
gene id: 268739:NMLP_RS04630
uniprot id: M1XPX6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

268739:NMLP RS06095
gene id: 268739:NMLP_RS06095
uniprot id: M1XQR2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS04870
gene id: 268739:NMLP_RS04870
uniprot id: M1XQ11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
messages: Cytoplasm

268739:NMLP RS06450
gene id: 268739:NMLP_RS06450
uniprot id: M1Y229
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

268739:NMLP RS03145
gene id: 268739:NMLP_RS03145
uniprot id: M1XP99
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

268739:NMLP RS11295
gene id: 268739:NMLP_RS11295
uniprot id: M1XLD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

268739:NMLP RS03000
gene id: 268739:NMLP_RS03000
uniprot id: M1XKF7
names: Similarity
messages: Belongs to the UPF0045 family.

268739:NMLP RS01695
gene id: 268739:NMLP_RS01695
uniprot id: M1XNP0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

268739:NMLP RS01965
gene id: 268739:NMLP_RS01965
uniprot id: M1XNS2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

268739:NMLP RS09995
gene id: 268739:NMLP_RS09995
uniprot id: M1XL81
names: Subcellular Location Annotation
messages: Cytoplasm

268739:NMLP RS06445
gene id: 268739:NMLP_RS06445
uniprot id: M1XQS4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

268739:NMLP RS13680
gene id: 268739:NMLP_RS13680
uniprot id: M1XLM8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA.

268739:NMLP RS09590
gene id: 268739:NMLP_RS09590
uniprot id: M1XS60
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

268739:NMLP RS12215
gene id: 268739:NMLP_RS12215
uniprot id: M1XTC1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS03480
gene id: 268739:NMLP_RS03480
uniprot id: M1Y0E0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

268739:NMLP RS12785
gene id: 268739:NMLP_RS12785
uniprot id: M1XTK9
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

268739:NMLP RS13685
gene id: 268739:NMLP_RS13685
uniprot id: M1XU19
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

268739:NMLP RS02825
gene id: 268739:NMLP_RS02825
uniprot id: M1XKF0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS00975
gene id: 268739:NMLP_RS00975
uniprot id: M1XND1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

268739:NMLP RS13810
gene id: 268739:NMLP_RS13810
uniprot id: M1XU66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

268739:NMLP RS09230
gene id: 268739:NMLP_RS09230
uniprot id: M1XS12
names: Similarity
messages: Belongs to the AAA ATPase family.

268739:NMLP RS09465
gene id: 268739:NMLP_RS09465
uniprot id: M1XS51
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

268739:NMLP RS05420
gene id: 268739:NMLP_RS05420
uniprot id: M1XQA4
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS01960
gene id: 268739:NMLP_RS01960
uniprot id: M1XKB6
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

268739:NMLP RS12695
gene id: 268739:NMLP_RS12695
uniprot id: M1XTJ5
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS05990
gene id: 268739:NMLP_RS05990
uniprot id: M1Y1S8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

268739:NMLP RS00600
gene id: 268739:NMLP_RS00600
uniprot id: M1XN67
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

268739:NMLP RS10620
gene id: 268739:NMLP_RS10620
uniprot id: M1XSM1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS04825
gene id: 268739:NMLP_RS04825
uniprot id: M1XQ17
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

268739:NMLP RS10295
gene id: 268739:NMLP_RS10295
uniprot id: M1Y448
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS12505
gene id: 268739:NMLP_RS12505
uniprot id: M1XTF2
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

268739:NMLP RS11245
gene id: 268739:NMLP_RS11245
uniprot id: M1XLD0
names: Similarity
messages: Belongs to the DAMOX/DASOX family.

268739:NMLP RS02920
gene id: 268739:NMLP_RS02920
uniprot id: M1XKF4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

268739:NMLP RS00505
gene id: 268739:NMLP_RS00505
uniprot id: M1XN37
names: Similarity
messages: Belongs to the UPF0201 family.

268739:NMLP RS08250
gene id: 268739:NMLP_RS08250
uniprot id: M1XRK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Homodimer.

268739:NMLP RS02720
gene id: 268739:NMLP_RS02720
uniprot id: M1XP16
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

268739:NMLP RS01000
gene id: 268739:NMLP_RS01000
uniprot id: M1XND6
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

268739:NMLP RS10675
gene id: 268739:NMLP_RS10675
uniprot id: M1XSN2
names: Similarity
messages: Belongs to the citrate synthase family.

268739:NMLP RS05320
gene id: 268739:NMLP_RS05320
uniprot id: M1XKP9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS03525
gene id: 268739:NMLP_RS03525
uniprot id: M1XKH8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

268739:NMLP RS10770
gene id: 268739:NMLP_RS10770
uniprot id: M1XLB2
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

268739:NMLP RS05500
gene id: 268739:NMLP_RS05500
uniprot id: M1XKQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

268739:NMLP RS08300
gene id: 268739:NMLP_RS08300
uniprot id: M1XRK9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

268739:NMLP RS03680
gene id: 268739:NMLP_RS03680
uniprot id: M1XPN3
names: Function
names: Subcellular Location Annotation
messages: May play a structural or regulatory role in gas vesicle synthesis.
messages: Vesicle
messages: gas vesicle

268739:NMLP RS13475
gene id: 268739:NMLP_RS13475
uniprot id: M1Y5V8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

268739:NMLP RS00935
gene id: 268739:NMLP_RS00935
uniprot id: M1XK76
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

268739:NMLP RS01780
gene id: 268739:NMLP_RS01780
uniprot id: M1XZH2
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS02240
gene id: 268739:NMLP_RS02240
uniprot id: M1XKC7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS05280
gene id: 268739:NMLP_RS05280
uniprot id: M1Y1C8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

268739:NMLP RS08025
gene id: 268739:NMLP_RS08025
uniprot id: M1XRK6
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

268739:NMLP RS09555
gene id: 268739:NMLP_RS09555
uniprot id: M1XS85
names: Similarity
messages: Belongs to the cytochrome P450 family.

268739:NMLP RS03880
gene id: 268739:NMLP_RS03880
uniprot id: M1XPM2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

268739:NMLP RS13455
gene id: 268739:NMLP_RS13455
uniprot id: M1XU20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

268739:NMLP RS02180
gene id: 268739:NMLP_RS02180
uniprot id: M1XNX1
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.

268739:NMLP RS03235
gene id: 268739:NMLP_RS03235
uniprot id: M1XPB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

268739:NMLP RS08165
gene id: 268739:NMLP_RS08165
uniprot id: M1Y2Y0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

268739:NMLP RS03910
gene id: 268739:NMLP_RS03910
uniprot id: M1XPS4
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

268739:NMLP RS02365
gene id: 268739:NMLP_RS02365
uniprot id: M1XNW1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS11485
gene id: 268739:NMLP_RS11485
uniprot id: M1Y4U5
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

268739:NMLP RS11595
gene id: 268739:NMLP_RS11595
uniprot id: M1XT56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

268739:NMLP RS12970
gene id: 268739:NMLP_RS12970
uniprot id: M1Y5K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

268739:NMLP RS08575
gene id: 268739:NMLP_RS08575
uniprot id: M1XRU5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

268739:NMLP RS01930
gene id: 268739:NMLP_RS01930
uniprot id: M1XNS1
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS13915
gene id: 268739:NMLP_RS13915
uniprot id: M1XU12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

268739:NMLP RS08985
gene id: 268739:NMLP_RS08985
uniprot id: M1XS17
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS12155
gene id: 268739:NMLP_RS12155
uniprot id: M1Y555
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

268739:NMLP RS01830
gene id: 268739:NMLP_RS01830
uniprot id: M1XZI0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

268739:NMLP RS10935
gene id: 268739:NMLP_RS10935
uniprot id: M1Y4I9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

268739:NMLP RS00695
gene id: 268739:NMLP_RS00695
uniprot id: M1XYY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

268739:NMLP RS13450
gene id: 268739:NMLP_RS13450
uniprot id: M1Y5V2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

268739:NMLP RS10235
gene id: 268739:NMLP_RS10235
uniprot id: M1XSE8
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

268739:NMLP RS11105
gene id: 268739:NMLP_RS11105
uniprot id: M1Y4L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

268739:NMLP RS13195
gene id: 268739:NMLP_RS13195
uniprot id: M1Y5Q2
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

268739:NMLP RS06000
gene id: 268739:NMLP_RS06000
uniprot id: M1XQI5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

268739:NMLP RS06460
gene id: 268739:NMLP_RS06460
uniprot id: M1XQT1
names: Similarity
messages: Belongs to the NOP10 family.

268739:NMLP RS11265
gene id: 268739:NMLP_RS11265
uniprot id: M1XSX1
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

268739:NMLP RS08715
gene id: 268739:NMLP_RS08715
uniprot id: M1XRW4
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

268739:NMLP RS15780
gene id: 268739:NMLP_RS15780
uniprot id: M1XPI7
names: Function
names: Similarity
messages: Belongs to the gas vesicle protein type A family.
messages: Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth.

268739:NMLP RS13555
gene id: 268739:NMLP_RS13555
uniprot id: M1XU35
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS03770
gene id: 268739:NMLP_RS03770
uniprot id: M1XKI8
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

268739:NMLP RS09395
gene id: 268739:NMLP_RS09395
uniprot id: M1Y3M8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

268739:NMLP RS06815
gene id: 268739:NMLP_RS06815
uniprot id: M1XKV8
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS07055
gene id: 268739:NMLP_RS07055
uniprot id: M1XKW7
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

268739:NMLP RS00245
gene id: 268739:NMLP_RS00245
uniprot id: M1XN09
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

268739:NMLP RS12015
gene id: 268739:NMLP_RS12015
uniprot id: M1XTC5
names: Similarity
messages: Belongs to the UPF0175 family.

268739:NMLP RS07695
gene id: 268739:NMLP_RS07695
uniprot id: M1XRB5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS01455
gene id: 268739:NMLP_RS01455
uniprot id: M1XNK6
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS10960
gene id: 268739:NMLP_RS10960
uniprot id: M1Y4J6
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

268739:NMLP RS05560
gene id: 268739:NMLP_RS05560
uniprot id: M1Y1I8
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

268739:NMLP RS03040
gene id: 268739:NMLP_RS03040
uniprot id: M1XP74
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

268739:NMLP RS08150
gene id: 268739:NMLP_RS08150
uniprot id: M1XRI3
names: Similarity
messages: Belongs to the Dps family.

268739:NMLP RS08360
gene id: 268739:NMLP_RS08360
uniprot id: M1XRL8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS13590
gene id: 268739:NMLP_RS13590
uniprot id: M1XU01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

268739:NMLP RS13290
gene id: 268739:NMLP_RS13290
uniprot id: M1XTU6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

268739:NMLP RS00485
gene id: 268739:NMLP_RS00485
uniprot id: M1XN35
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

268739:NMLP RS06250
gene id: 268739:NMLP_RS06250
uniprot id: M1XQT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

268739:NMLP RS01045
gene id: 268739:NMLP_RS01045
uniprot id: M1XZ45
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

268739:NMLP RS09625
gene id: 268739:NMLP_RS09625
uniprot id: M1XS73
names: Subcellular Location Annotation
messages: Cell membrane

268739:NMLP RS12420
gene id: 268739:NMLP_RS12420
uniprot id: M1XLH7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS12655
gene id: 268739:NMLP_RS12655
uniprot id: M1XTM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

268739:NMLP RS00550
gene id: 268739:NMLP_RS00550
uniprot id: M1XN60
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

268739:NMLP RS08240
gene id: 268739:NMLP_RS08240
uniprot id: M1Y2Z6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

268739:NMLP RS07125
gene id: 268739:NMLP_RS07125
uniprot id: M1XR73
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

268739:NMLP RS05785
gene id: 268739:NMLP_RS05785
uniprot id: M1Y1N6
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

268739:NMLP RS02315
gene id: 268739:NMLP_RS02315
uniprot id: M1XNZ3
names: Similarity
messages: Belongs to the PrpD family.

268739:NMLP RS11760
gene id: 268739:NMLP_RS11760
uniprot id: M1Y4Z2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

268739:NMLP RS00580
gene id: 268739:NMLP_RS00580
uniprot id: M1XN52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

268739:NMLP RS10555
gene id: 268739:NMLP_RS10555
uniprot id: M1XSN6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

268739:NMLP RS03990
gene id: 268739:NMLP_RS03990
uniprot id: M1XPN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

268739:NMLP RS00855
gene id: 268739:NMLP_RS00855
uniprot id: M1XN97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

268739:NMLP RS10750
gene id: 268739:NMLP_RS10750
uniprot id: M1XSP6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

268739:NMLP RS02960
gene id: 268739:NMLP_RS02960
uniprot id: M1XP95
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

268739:NMLP RS12270
gene id: 268739:NMLP_RS12270
uniprot id: M1XTD7
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

268739:NMLP RS02950
gene id: 268739:NMLP_RS02950
uniprot id: M1XP70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

268739:NMLP RS02035
gene id: 268739:NMLP_RS02035
uniprot id: M1XNR5
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

268739:NMLP RS00690
gene id: 268739:NMLP_RS00690
uniprot id: M1XN69
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS01550
gene id: 268739:NMLP_RS01550
uniprot id: M1XZD2
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

268739:NMLP RS08080
gene id: 268739:NMLP_RS08080
uniprot id: M1XRL4
names: Similarity
messages: Belongs to the UPF0175 family.

268739:NMLP RS07995
gene id: 268739:NMLP_RS07995
uniprot id: M1Y2U5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

268739:NMLP RS02005
gene id: 268739:NMLP_RS02005
uniprot id: M1XNT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family. BdbC subfamily.
messages: Membrane

268739:NMLP RS09520
gene id: 268739:NMLP_RS09520
uniprot id: M1XS59
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

268739:NMLP RS06790
gene id: 268739:NMLP_RS06790
uniprot id: M1XKV7
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

268739:NMLP RS10855
gene id: 268739:NMLP_RS10855
uniprot id: M1XSR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

268739:NMLP RS14545
gene id: 268739:NMLP_RS14545
uniprot id: M1XSJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

268739:NMLP RS05200
gene id: 268739:NMLP_RS05200
uniprot id: M1Y1B1
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

268739:NMLP RS11530
gene id: 268739:NMLP_RS11530
uniprot id: M1XLE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

268739:NMLP RS13320
gene id: 268739:NMLP_RS13320
uniprot id: M1XTV0
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS08195
gene id: 268739:NMLP_RS08195
uniprot id: M1XRN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

268739:NMLP RS11630
gene id: 268739:NMLP_RS11630
uniprot id: M1XLE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

268739:NMLP RS11590
gene id: 268739:NMLP_RS11590
uniprot id: M1Y4W5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

268739:NMLP RS05765
gene id: 268739:NMLP_RS05765
uniprot id: M1XQE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

268739:NMLP RS06900
gene id: 268739:NMLP_RS06900
uniprot id: M1XKW1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

268739:NMLP RS06070
gene id: 268739:NMLP_RS06070
uniprot id: M1XQR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

268739:NMLP RS14665
gene id: 268739:NMLP_RS14665
uniprot id: M1XLM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

268739:NMLP RS02945
gene id: 268739:NMLP_RS02945
uniprot id: M1XKF5
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

268739:NMLP RS01225
gene id: 268739:NMLP_RS01225
uniprot id: M1XNG8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS01610
gene id: 268739:NMLP_RS01610
uniprot id: M1XNN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

268739:NMLP RS10355
gene id: 268739:NMLP_RS10355
uniprot id: M1XSG7
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

268739:NMLP RS02695
gene id: 268739:NMLP_RS02695
uniprot id: M1XP12
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS08670
gene id: 268739:NMLP_RS08670
uniprot id: M1XL30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

268739:NMLP RS08770
gene id: 268739:NMLP_RS08770
uniprot id: M1XRT9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

268739:NMLP RS06850
gene id: 268739:NMLP_RS06850
uniprot id: M1XQY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

268739:NMLP RS03395
gene id: 268739:NMLP_RS03395
uniprot id: M1XKH3
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

268739:NMLP RS01195
gene id: 268739:NMLP_RS01195
uniprot id: M1XZ71
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in both the arginine and lysine biosynthetic pathways.

268739:NMLP RS13185
gene id: 268739:NMLP_RS13185
uniprot id: M1XLK8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

268739:NMLP RS12540
gene id: 268739:NMLP_RS12540
uniprot id: M1XTH2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

268739:NMLP RS04535
gene id: 268739:NMLP_RS04535
uniprot id: M1XKL9
names: Caution
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS00860
gene id: 268739:NMLP_RS00860
uniprot id: M1XK73
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS03705
gene id: 268739:NMLP_RS03705
uniprot id: M1XPN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

268739:NMLP RS05360
gene id: 268739:NMLP_RS05360
uniprot id: M1XQE0
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

268739:NMLP RS06810
gene id: 268739:NMLP_RS06810
uniprot id: M1XQY8
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS12835
gene id: 268739:NMLP_RS12835
uniprot id: M1XLJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

268739:NMLP RS00850
gene id: 268739:NMLP_RS00850
uniprot id: M1XNB5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

268739:NMLP RS11900
gene id: 268739:NMLP_RS11900
uniprot id: M1XT79
names: Subcellular Location Annotation
messages: Cytoplasm

268739:NMLP RS02580
gene id: 268739:NMLP_RS02580
uniprot id: M1XP33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

268739:NMLP RS11270
gene id: 268739:NMLP_RS11270
uniprot id: M1XLD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Membrane

268739:NMLP RS08245
gene id: 268739:NMLP_RS08245
uniprot id: M1XRP2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

268739:NMLP RS06185
gene id: 268739:NMLP_RS06185
uniprot id: M1XQL4
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

268739:NMLP RS04570
gene id: 268739:NMLP_RS04570
uniprot id: M1Y0Y2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

268739:NMLP RS08185
gene id: 268739:NMLP_RS08185
uniprot id: M1XRL7
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

268739:NMLP RS02760
gene id: 268739:NMLP_RS02760
uniprot id: M1XZZ7
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

268739:NMLP RS01725
gene id: 268739:NMLP_RS01725
uniprot id: M1XZG7
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS00875
gene id: 268739:NMLP_RS00875
uniprot id: M1XNB8
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

268739:NMLP RS10535
gene id: 268739:NMLP_RS10535
uniprot id: M1XSK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

268739:NMLP RS09570
gene id: 268739:NMLP_RS09570
uniprot id: M1XL64
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

268739:NMLP RS09490
gene id: 268739:NMLP_RS09490
uniprot id: M1XS56
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

268739:NMLP RS11710
gene id: 268739:NMLP_RS11710
uniprot id: M1XT50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

268739:NMLP RS07990
gene id: 268739:NMLP_RS07990
uniprot id: M1XRI4
names: Similarity
messages: Belongs to the DNA photolyase family.

268739:NMLP RS13410
gene id: 268739:NMLP_RS13410
uniprot id: M1XTT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

268739:NMLP RS02540
gene id: 268739:NMLP_RS02540
uniprot id: M1XP24
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

268739:NMLP RS00765
gene id: 268739:NMLP_RS00765
uniprot id: M1XN79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

268739:NMLP RS05850
gene id: 268739:NMLP_RS05850
uniprot id: M1XKS0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

268739:NMLP RS03125
gene id: 268739:NMLP_RS03125
uniprot id: M1XP94
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

268739:NMLP RS06635
gene id: 268739:NMLP_RS06635
uniprot id: M1XKV1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

268739:NMLP RS09765
gene id: 268739:NMLP_RS09765
uniprot id: M1XS82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

268739:NMLP RS04350
gene id: 268739:NMLP_RS04350
uniprot id: M1Y0T9
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS11400
gene id: 268739:NMLP_RS11400
uniprot id: M1XLD6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

268739:NMLP RS13945
gene id: 268739:NMLP_RS13945
uniprot id: M1XU38
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

268739:NMLP RS04090
gene id: 268739:NMLP_RS04090
uniprot id: M1XPP7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

268739:NMLP RS09955
gene id: 268739:NMLP_RS09955
uniprot id: M1Y3Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

268739:NMLP RS06520
gene id: 268739:NMLP_RS06520
uniprot id: M1Y243
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS02735
gene id: 268739:NMLP_RS02735
uniprot id: M1XZZ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

268739:NMLP RS10685
gene id: 268739:NMLP_RS10685
uniprot id: M1XSQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

268739:NMLP RS11920
gene id: 268739:NMLP_RS11920
uniprot id: M1XTA7
names: Similarity
messages: Belongs to the DNA photolyase family.

268739:NMLP RS08845
gene id: 268739:NMLP_RS08845
uniprot id: M1XRV0
names: Similarity
messages: Belongs to the acylphosphatase family.

268739:NMLP RS00920
gene id: 268739:NMLP_RS00920
uniprot id: M1XZ25
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

268739:NMLP RS02890
gene id: 268739:NMLP_RS02890
uniprot id: M1XP43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

268739:NMLP RS02715
gene id: 268739:NMLP_RS02715
uniprot id: M1XP49
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit.

268739:NMLP RS00985
gene id: 268739:NMLP_RS00985
uniprot id: M1XK78
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

268739:NMLP RS12210
gene id: 268739:NMLP_RS12210
uniprot id: M1XTF4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

268739:NMLP RS08825
gene id: 268739:NMLP_RS08825
uniprot id: M1XL36
names: Similarity
messages: Belongs to the UPF0212 family.

268739:NMLP RS05920
gene id: 268739:NMLP_RS05920
uniprot id: M1XQM5
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS08335
gene id: 268739:NMLP_RS08335
uniprot id: M1XRL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

268739:NMLP RS09275
gene id: 268739:NMLP_RS09275
uniprot id: M1XS14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

268739:NMLP RS14165
gene id: 268739:NMLP_RS14165
uniprot id: M1Y0L4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

268739:NMLP RS12415
gene id: 268739:NMLP_RS12415
uniprot id: M1XTE5
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS04165
gene id: 268739:NMLP_RS04165
uniprot id: M1XPQ6
names: Similarity
messages: Belongs to the PEPCase type 1 family.

268739:NMLP RS06435
gene id: 268739:NMLP_RS06435
uniprot id: M1XQT0
names: Similarity
messages: Belongs to the PspA/IM30 family.

268739:NMLP RS10000
gene id: 268739:NMLP_RS10000
uniprot id: M1XSB5
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS11725
gene id: 268739:NMLP_RS11725
uniprot id: M1XT57
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

268739:NMLP RS03415
gene id: 268739:NMLP_RS03415
uniprot id: M1XPD0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

268739:NMLP RS00645
gene id: 268739:NMLP_RS00645
uniprot id: M1XYX5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

268739:NMLP RS00970
gene id: 268739:NMLP_RS00970
uniprot id: M1XZ31
names: Similarity
messages: Belongs to the TrpC family.

268739:NMLP RS06220
gene id: 268739:NMLP_RS06220
uniprot id: M1Y1X7
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

268739:NMLP RS08580
gene id: 268739:NMLP_RS08580
uniprot id: M1XRQ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

268739:NMLP RS03400
gene id: 268739:NMLP_RS03400
uniprot id: M1XPE2
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

268739:NMLP RS08000
gene id: 268739:NMLP_RS08000
uniprot id: M1XRK0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

268739:NMLP RS13125
gene id: 268739:NMLP_RS13125
uniprot id: M1XTW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

268739:NMLP RS03970
gene id: 268739:NMLP_RS03970
uniprot id: M1XKJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

268739:NMLP RS01760
gene id: 268739:NMLP_RS01760
uniprot id: M1XNQ4
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS02685
gene id: 268739:NMLP_RS02685
uniprot id: M1XZY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

268739:NMLP RS01955
gene id: 268739:NMLP_RS01955
uniprot id: M1XNQ5
names: Caution
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS07720
gene id: 268739:NMLP_RS07720
uniprot id: M1XRB8
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

268739:NMLP RS11950
gene id: 268739:NMLP_RS11950
uniprot id: M1XT88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

268739:NMLP RS05710
gene id: 268739:NMLP_RS05710
uniprot id: M1XQH1
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS10360
gene id: 268739:NMLP_RS10360
uniprot id: M1XL95
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

268739:NMLP RS06705
gene id: 268739:NMLP_RS06705
uniprot id: M1XR05
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

268739:NMLP RS13570
gene id: 268739:NMLP_RS13570
uniprot id: M1XTZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

268739:NMLP RS00160
gene id: 268739:NMLP_RS00160
uniprot id: M1XMX3
names: Similarity
messages: Belongs to the RutC family.

268739:NMLP RS08390
gene id: 268739:NMLP_RS08390
uniprot id: M1XL19
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

268739:NMLP RS08975
gene id: 268739:NMLP_RS08975
uniprot id: M1XRZ6
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

268739:NMLP RS02910
gene id: 268739:NMLP_RS02910
uniprot id: M1XP84
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

268739:NMLP RS01525
gene id: 268739:NMLP_RS01525
uniprot id: M1XZC7
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

268739:NMLP RS06805
gene id: 268739:NMLP_RS06805
uniprot id: M1XR21
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS12975
gene id: 268739:NMLP_RS12975
uniprot id: M1XTT5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS00075
gene id: 268739:NMLP_RS00075
uniprot id: M1XK43
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

268739:NMLP RS09370
gene id: 268739:NMLP_RS09370
uniprot id: M1Y3M4
names: Function
messages: Part of a potassium transport system.

268739:NMLP RS13465
gene id: 268739:NMLP_RS13465
uniprot id: M1XLL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

268739:NMLP RS03315
gene id: 268739:NMLP_RS03315
uniprot id: M1XPH0
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

268739:NMLP RS08950
gene id: 268739:NMLP_RS08950
uniprot id: M1XRZ3
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS01200
gene id: 268739:NMLP_RS01200
uniprot id: M1XNG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS09945
gene id: 268739:NMLP_RS09945
uniprot id: M1XL79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

268739:NMLP RS06820
gene id: 268739:NMLP_RS06820
uniprot id: M1XQY3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

268739:NMLP RS00615
gene id: 268739:NMLP_RS00615
uniprot id: M1XN56
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS02460
gene id: 268739:NMLP_RS02460
uniprot id: M1XP14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

268739:NMLP RS09060
gene id: 268739:NMLP_RS09060
uniprot id: M1XS04
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

268739:NMLP RS13660
gene id: 268739:NMLP_RS13660
uniprot id: M1XU11
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS10505
gene id: 268739:NMLP_RS10505
uniprot id: M1XSM9
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

268739:NMLP RS08855
gene id: 268739:NMLP_RS08855
uniprot id: M1XRX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

268739:NMLP RS05755
gene id: 268739:NMLP_RS05755
uniprot id: M1XQK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

268739:NMLP RS04140
gene id: 268739:NMLP_RS04140
uniprot id: M1XPQ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

268739:NMLP RS02040
gene id: 268739:NMLP_RS02040
uniprot id: M1XKB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH.
messages: Homotetramer.

268739:NMLP RS10230
gene id: 268739:NMLP_RS10230
uniprot id: M1XL90
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

268739:NMLP RS02170
gene id: 268739:NMLP_RS02170
uniprot id: M1XNV1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

268739:NMLP RS03035
gene id: 268739:NMLP_RS03035
uniprot id: M1XPA8
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

268739:NMLP RS10175
gene id: 268739:NMLP_RS10175
uniprot id: M1XSD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

268739:NMLP RS09455
gene id: 268739:NMLP_RS09455
uniprot id: M1XS45
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS04255
gene id: 268739:NMLP_RS04255
uniprot id: M1Y0S2
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

268739:NMLP RS06565
gene id: 268739:NMLP_RS06565
uniprot id: M1Y249
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS10645
gene id: 268739:NMLP_RS10645
uniprot id: M1XLA7
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

268739:NMLP RS13520
gene id: 268739:NMLP_RS13520
uniprot id: M1XTY6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

268739:NMLP RS02980
gene id: 268739:NMLP_RS02980
uniprot id: M1Y042
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

268739:NMLP RS00380
gene id: 268739:NMLP_RS00380
uniprot id: M1XK54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Homodimer.

268739:NMLP RS03365
gene id: 268739:NMLP_RS03365
uniprot id: M1XPC3
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

268739:NMLP RS09415
gene id: 268739:NMLP_RS09415
uniprot id: M1XS44
names: Similarity
messages: Belongs to the glutamate synthase family.

268739:NMLP RS10210
gene id: 268739:NMLP_RS10210
uniprot id: M1XSE4
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

268739:NMLP RS07130
gene id: 268739:NMLP_RS07130
uniprot id: M1XR27
names: Similarity
messages: Belongs to the glutaredoxin family.

268739:NMLP RS10195
gene id: 268739:NMLP_RS10195
uniprot id: M1XSH3
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

268739:NMLP RS01855
gene id: 268739:NMLP_RS01855
uniprot id: M1XNQ6
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

268739:NMLP RS07840
gene id: 268739:NMLP_RS07840
uniprot id: M1XRG2
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

268739:NMLP RS04845
gene id: 268739:NMLP_RS04845
uniprot id: M1XQ04
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

268739:NMLP RS05135
gene id: 268739:NMLP_RS05135
uniprot id: M1XKP2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

268739:NMLP RS08450
gene id: 268739:NMLP_RS08450
uniprot id: M1XRN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

268739:NMLP RS01530
gene id: 268739:NMLP_RS01530
uniprot id: M1XNL9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

268739:NMLP RS08235
gene id: 268739:NMLP_RS08235
uniprot id: M1XRM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

268739:NMLP RS08160
gene id: 268739:NMLP_RS08160
uniprot id: M1XRL3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

268739:NMLP RS07575
gene id: 268739:NMLP_RS07575
uniprot id: M1XKY7
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

268739:NMLP RS12230
gene id: 268739:NMLP_RS12230
uniprot id: M1Y568
names: Similarity
messages: Belongs to the phosphohexose mutase family.

268739:NMLP RS08280
gene id: 268739:NMLP_RS08280
uniprot id: M1XL15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

268739:NMLP RS12700
gene id: 268739:NMLP_RS12700
uniprot id: M1Y5F6
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS11785
gene id: 268739:NMLP_RS11785
uniprot id: M1Y4Z7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS09780
gene id: 268739:NMLP_RS09780
uniprot id: M1Y3U6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

268739:NMLP RS01775
gene id: 268739:NMLP_RS01775
uniprot id: M1XNP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

268739:NMLP RS08320
gene id: 268739:NMLP_RS08320
uniprot id: M1Y324
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

268739:NMLP RS13885
gene id: 268739:NMLP_RS13885
uniprot id: M1XU72
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

268739:NMLP RS07225
gene id: 268739:NMLP_RS07225
uniprot id: M1XKX4
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS02305
gene id: 268739:NMLP_RS02305
uniprot id: M1XNW0
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.

268739:NMLP RS05625
gene id: 268739:NMLP_RS05625
uniprot id: M1XQI7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

268739:NMLP RS13315
gene id: 268739:NMLP_RS13315
uniprot id: M1XLL3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS06755
gene id: 268739:NMLP_RS06755
uniprot id: M1XR13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

268739:NMLP RS02090
gene id: 268739:NMLP_RS02090
uniprot id: M1XKC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

268739:NMLP RS01555
gene id: 268739:NMLP_RS01555
uniprot id: M1XNM2
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS14560
gene id: 268739:NMLP_RS14560
uniprot id: M1XLB5
names: Similarity
messages: Belongs to the HerA family.

268739:NMLP RS07485
gene id: 268739:NMLP_RS07485
uniprot id: M1XR90
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

268739:NMLP RS02350
gene id: 268739:NMLP_RS02350
uniprot id: M1XKD1
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

268739:NMLP RS02815
gene id: 268739:NMLP_RS02815
uniprot id: M1XP65
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

268739:NMLP RS06665
gene id: 268739:NMLP_RS06665
uniprot id: M1XKV2
names: Similarity
messages: Belongs to the Ahb/Nir family.

268739:NMLP RS00830
gene id: 268739:NMLP_RS00830
uniprot id: M1XN92
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS01165
gene id: 268739:NMLP_RS01165
uniprot id: M1XND7
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

268739:NMLP RS00440
gene id: 268739:NMLP_RS00440
uniprot id: M1XN42
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS09070
gene id: 268739:NMLP_RS09070
uniprot id: M1XS26
names: Similarity
messages: Belongs to the PdaD family.

268739:NMLP RS06160
gene id: 268739:NMLP_RS06160
uniprot id: M1XQL0
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: The active site is a redox-active disulfide bond.

268739:NMLP RS06735
gene id: 268739:NMLP_RS06735
uniprot id: M1XQX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

268739:NMLP RS02360
gene id: 268739:NMLP_RS02360
uniprot id: M1XP00
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS08980
gene id: 268739:NMLP_RS08980
uniprot id: M1Y3G5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

268739:NMLP RS08870
gene id: 268739:NMLP_RS08870
uniprot id: M1XRV5
names: Similarity
messages: Belongs to the UPF0212 family.

268739:NMLP RS02560
gene id: 268739:NMLP_RS02560
uniprot id: M1XNY8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS02215
gene id: 268739:NMLP_RS02215
uniprot id: M1XKC6
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

268739:NMLP RS11695
gene id: 268739:NMLP_RS11695
uniprot id: M1XT74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

268739:NMLP RS05125
gene id: 268739:NMLP_RS05125
uniprot id: M1XQ94
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

268739:NMLP RS02865
gene id: 268739:NMLP_RS02865
uniprot id: M1XP42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

268739:NMLP RS03735
gene id: 268739:NMLP_RS03735
uniprot id: M1XPP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

268739:NMLP RS13485
gene id: 268739:NMLP_RS13485
uniprot id: M1XTU2
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

268739:NMLP RS10305
gene id: 268739:NMLP_RS10305
uniprot id: M1XSF8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

268739:NMLP RS08270
gene id: 268739:NMLP_RS08270
uniprot id: M1XRP6
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

268739:NMLP RS00420
gene id: 268739:NMLP_RS00420
uniprot id: M1XN25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

268739:NMLP RS12625
gene id: 268739:NMLP_RS12625
uniprot id: M1XTL9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

268739:NMLP RS03620
gene id: 268739:NMLP_RS03620
uniprot id: M1XPH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.
messages: Vesicle
messages: gas vesicle

268739:NMLP RS02200
gene id: 268739:NMLP_RS02200
uniprot id: M1XZP2
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

268739:NMLP RS01540
gene id: 268739:NMLP_RS01540
uniprot id: M1XKA0
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

268739:NMLP RS13415
gene id: 268739:NMLP_RS13415
uniprot id: M1XLL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

268739:NMLP RS12325
gene id: 268739:NMLP_RS12325
uniprot id: M1Y586
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS04820
gene id: 268739:NMLP_RS04820
uniprot id: M1XKN0
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

268739:NMLP RS10310
gene id: 268739:NMLP_RS10310
uniprot id: M1XL93
names: Similarity
messages: Belongs to the LeuD family. LeuD type 2 subfamily.

268739:NMLP RS00020
gene id: 268739:NMLP_RS00020
uniprot id: M1XMV6
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

268739:NMLP RS13585
gene id: 268739:NMLP_RS13585
uniprot id: M1XLM4
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS10550
gene id: 268739:NMLP_RS10550
uniprot id: M1Y4B0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

268739:NMLP RS04010
gene id: 268739:NMLP_RS04010
uniprot id: M1XPU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

268739:NMLP RS01090
gene id: 268739:NMLP_RS01090
uniprot id: M1XNC9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

268739:NMLP RS01175
gene id: 268739:NMLP_RS01175
uniprot id: M1XNG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

268739:NMLP RS00040
gene id: 268739:NMLP_RS00040
uniprot id: M1XYN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

268739:NMLP RS10760
gene id: 268739:NMLP_RS10760
uniprot id: M1XSS0
names: Similarity
messages: Belongs to the Ahb/Nir family.

268739:NMLP RS02030
gene id: 268739:NMLP_RS02030
uniprot id: M1XNU2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.

268739:NMLP RS00045
gene id: 268739:NMLP_RS00045
uniprot id: M1XMX8
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

268739:NMLP RS01275
gene id: 268739:NMLP_RS01275
uniprot id: M1XNH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

268739:NMLP RS13930
gene id: 268739:NMLP_RS13930
uniprot id: M1XU76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

268739:NMLP RS10825
gene id: 268739:NMLP_RS10825
uniprot id: M1XSQ9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

268739:NMLP RS04915
gene id: 268739:NMLP_RS04915
uniprot id: M1XQ18
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

268739:NMLP RS11800
gene id: 268739:NMLP_RS11800
uniprot id: M1XLF2
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

268739:NMLP RS00325
gene id: 268739:NMLP_RS00325
uniprot id: M1XN07
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

268739:NMLP RS11565
gene id: 268739:NMLP_RS11565
uniprot id: M1Y4W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

268739:NMLP RS04375
gene id: 268739:NMLP_RS04375
uniprot id: M1XPY5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS12525
gene id: 268739:NMLP_RS12525
uniprot id: M1XTK0
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS13550
gene id: 268739:NMLP_RS13550
uniprot id: M1Y5X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

268739:NMLP RS00670
gene id: 268739:NMLP_RS00670
uniprot id: M1XYX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the oxidation of methyl-H(4)MPT to methylene-H(4)MPT.
messages: Cytoplasm

268739:NMLP RS14555
gene id: 268739:NMLP_RS14555
uniprot id: M1XSM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

268739:NMLP RS03745
gene id: 268739:NMLP_RS03745
uniprot id: M1XKI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

268739:NMLP RS01220
gene id: 268739:NMLP_RS01220
uniprot id: M1XZ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

268739:NMLP RS06950
gene id: 268739:NMLP_RS06950
uniprot id: M1XKW3
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

268739:NMLP RS07195
gene id: 268739:NMLP_RS07195
uniprot id: M1XR85
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

268739:NMLP RS13625
gene id: 268739:NMLP_RS13625
uniprot id: M1XU47
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

268739:NMLP RS07580
gene id: 268739:NMLP_RS07580
uniprot id: M1XRB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS02475
gene id: 268739:NMLP_RS02475
uniprot id: M1XNY0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

268739:NMLP RS06525
gene id: 268739:NMLP_RS06525
uniprot id: M1XQY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

268739:NMLP RS07690
gene id: 268739:NMLP_RS07690
uniprot id: M1XRE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

268739:NMLP RS08880
gene id: 268739:NMLP_RS08880
uniprot id: M1XRX6
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

268739:NMLP RS10365
gene id: 268739:NMLP_RS10365
uniprot id: M1XSH0
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

268739:NMLP RS05750
gene id: 268739:NMLP_RS05750
uniprot id: M1Y1N1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

268739:NMLP RS10135
gene id: 268739:NMLP_RS10135
uniprot id: M1XSD2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

268739:NMLP RS08900
gene id: 268739:NMLP_RS08900
uniprot id: M1XRY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Nucleus

268739:NMLP RS00215
gene id: 268739:NMLP_RS00215
uniprot id: M1XYQ3
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS03900
gene id: 268739:NMLP_RS03900
uniprot id: M1XPM6
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

268739:NMLP RS02130
gene id: 268739:NMLP_RS02130
uniprot id: M1XNW4
names: Similarity
messages: Belongs to the SUI1 family.

268739:NMLP RS02900
gene id: 268739:NMLP_RS02900
uniprot id: M1XP60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

268739:NMLP RS09965
gene id: 268739:NMLP_RS09965
uniprot id: M1XSA8
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS02730
gene id: 268739:NMLP_RS02730
uniprot id: M1XP29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

268739:NMLP RS02575
gene id: 268739:NMLP_RS02575
uniprot id: M1XZW5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

268739:NMLP RS08730
gene id: 268739:NMLP_RS08730
uniprot id: M1XRV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

268739:NMLP RS06720
gene id: 268739:NMLP_RS06720
uniprot id: M1XQW9
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

268739:NMLP RS00190
gene id: 268739:NMLP_RS00190
uniprot id: M1XYP9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS09940
gene id: 268739:NMLP_RS09940
uniprot id: M1XSA5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS01035
gene id: 268739:NMLP_RS01035
uniprot id: M1XK80
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS02935
gene id: 268739:NMLP_RS02935
uniprot id: M1XP89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

268739:NMLP RS13335
gene id: 268739:NMLP_RS13335
uniprot id: M1XLL4
names: Similarity
messages: Belongs to the LarC family.

268739:NMLP RS09645
gene id: 268739:NMLP_RS09645
uniprot id: M1XL67
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

268739:NMLP RS02330
gene id: 268739:NMLP_RS02330
uniprot id: M1XNW2
names: Similarity
messages: Belongs to the MoaB/Mog family.

268739:NMLP RS00365
gene id: 268739:NMLP_RS00365
uniprot id: M1XYS5
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

268739:NMLP RS01580
gene id: 268739:NMLP_RS01580
uniprot id: M1XNM6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

268739:NMLP RS13470
gene id: 268739:NMLP_RS13470
uniprot id: M1XTX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

268739:NMLP RS12685
gene id: 268739:NMLP_RS12685
uniprot id: M1XTH1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS03505
gene id: 268739:NMLP_RS03505
uniprot id: M1XKH7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS09420
gene id: 268739:NMLP_RS09420
uniprot id: M1Y3N0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

268739:NMLP RS12040
gene id: 268739:NMLP_RS12040
uniprot id: M1XTC9
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS04240
gene id: 268739:NMLP_RS04240
uniprot id: M1XPR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

268739:NMLP RS08155
gene id: 268739:NMLP_RS08155
uniprot id: M1XL10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

268739:NMLP RS08875
gene id: 268739:NMLP_RS08875
uniprot id: M1XL38
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

268739:NMLP RS09665
gene id: 268739:NMLP_RS09665
uniprot id: M1XS68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

268739:NMLP RS00825
gene id: 268739:NMLP_RS00825
uniprot id: M1XNB2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS06935
gene id: 268739:NMLP_RS06935
uniprot id: M1Y2A6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

268739:NMLP RS07925
gene id: 268739:NMLP_RS07925
uniprot id: M1XL01
names: Similarity
messages: Belongs to the HepT RNase toxin family.

268739:NMLP RS12520
gene id: 268739:NMLP_RS12520
uniprot id: M1Y5C2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.
messages: Membrane

268739:NMLP RS03725
gene id: 268739:NMLP_RS03725
uniprot id: M1XPJ6
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS07295
gene id: 268739:NMLP_RS07295
uniprot id: M1XKX6
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

268739:NMLP RS05845
gene id: 268739:NMLP_RS05845
uniprot id: M1XQF9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

268739:NMLP RS02800
gene id: 268739:NMLP_RS02800
uniprot id: M1XKE9
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

268739:NMLP RS01185
gene id: 268739:NMLP_RS01185
uniprot id: M1XK86
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS02490
gene id: 268739:NMLP_RS02490
uniprot id: M1XP17
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

268739:NMLP RS12360
gene id: 268739:NMLP_RS12360
uniprot id: M1XTD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

268739:NMLP RS01705
gene id: 268739:NMLP_RS01705
uniprot id: M1XNP6
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

268739:NMLP RS10925
gene id: 268739:NMLP_RS10925
uniprot id: M1XLB8
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS08850
gene id: 268739:NMLP_RS08850
uniprot id: M1XL37
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS01575
gene id: 268739:NMLP_RS01575
uniprot id: M1XZD7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

268739:NMLP RS01845
gene id: 268739:NMLP_RS01845
uniprot id: M1XNN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

268739:NMLP RS04425
gene id: 268739:NMLP_RS04425
uniprot id: M1XPZ0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

268739:NMLP RS00390
gene id: 268739:NMLP_RS00390
uniprot id: M1XN31
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS13950
gene id: 268739:NMLP_RS13950
uniprot id: M1XLP0
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

268739:NMLP RS11495
gene id: 268739:NMLP_RS11495
uniprot id: M1XT25
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS08400
gene id: 268739:NMLP_RS08400
uniprot id: M1Y338
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

268739:NMLP RS06190
gene id: 268739:NMLP_RS06190
uniprot id: M1XKT3
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

268739:NMLP RS01605
gene id: 268739:NMLP_RS01605
uniprot id: M1XZE0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

268739:NMLP RS12170
gene id: 268739:NMLP_RS12170
uniprot id: M1XLG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homodimer.

268739:NMLP RS09335
gene id: 268739:NMLP_RS09335
uniprot id: M1XS23
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

268739:NMLP RS13305
gene id: 268739:NMLP_RS13305
uniprot id: M1XTZ5
names: Similarity
messages: Belongs to the AAA ATPase family.

268739:NMLP RS10910
gene id: 268739:NMLP_RS10910
uniprot id: M1XSS2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

268739:NMLP RS12950
gene id: 268739:NMLP_RS12950
uniprot id: M1XTS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

268739:NMLP RS11490
gene id: 268739:NMLP_RS11490
uniprot id: M1XT26
names: Similarity
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

268739:NMLP RS11070
gene id: 268739:NMLP_RS11070
uniprot id: M1XLC3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

268739:NMLP RS02190
gene id: 268739:NMLP_RS02190
uniprot id: M1XKC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

268739:NMLP RS10735
gene id: 268739:NMLP_RS10735
uniprot id: M1XSR6
names: Similarity
messages: Belongs to the DNA photolyase family.

268739:NMLP RS11805
gene id: 268739:NMLP_RS11805
uniprot id: M1XT61
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS13530
gene id: 268739:NMLP_RS13530
uniprot id: M1XU32
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

268739:NMLP RS04865
gene id: 268739:NMLP_RS04865
uniprot id: M1XQ55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

268739:NMLP RS05675
gene id: 268739:NMLP_RS05675
uniprot id: M1XQJ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS00965
gene id: 268739:NMLP_RS00965
uniprot id: M1XNA7
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

268739:NMLP RS11480
gene id: 268739:NMLP_RS11480
uniprot id: M1XT24
names: Similarity
messages: Belongs to the complex I subunit 3 family.

268739:NMLP RS03805
gene id: 268739:NMLP_RS03805
uniprot id: M1XPK7
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

268739:NMLP RS00685
gene id: 268739:NMLP_RS00685
uniprot id: M1XK66
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

268739:NMLP RS11730
gene id: 268739:NMLP_RS11730
uniprot id: M1XLE9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

268739:NMLP RS11225
gene id: 268739:NMLP_RS11225
uniprot id: M1XLC9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS02745
gene id: 268739:NMLP_RS02745
uniprot id: M1XP22
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

268739:NMLP RS02915
gene id: 268739:NMLP_RS02915
uniprot id: M1XP47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

268739:NMLP RS08675
gene id: 268739:NMLP_RS08675
uniprot id: M1XRU7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

268739:NMLP RS03195
gene id: 268739:NMLP_RS03195
uniprot id: M1XPE3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

268739:NMLP RS08255
gene id: 268739:NMLP_RS08255
uniprot id: M1XL14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

268739:NMLP RS12980
gene id: 268739:NMLP_RS12980
uniprot id: M1XTL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ModE family.
messages: Membrane

268739:NMLP RS12630
gene id: 268739:NMLP_RS12630
uniprot id: M1XTG5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

268739:NMLP RS09365
gene id: 268739:NMLP_RS09365
uniprot id: M1XS38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

268739:NMLP RS06570
gene id: 268739:NMLP_RS06570
uniprot id: M1XQZ3
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS06980
gene id: 268739:NMLP_RS06980
uniprot id: M1XKW4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS07255
gene id: 268739:NMLP_RS07255
uniprot id: M1XR44
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS02965
gene id: 268739:NMLP_RS02965
uniprot id: M1XP59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

268739:NMLP RS02925
gene id: 268739:NMLP_RS02925
uniprot id: M1XP64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

268739:NMLP RS12130
gene id: 268739:NMLP_RS12130
uniprot id: M1Y551
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

268739:NMLP RS12020
gene id: 268739:NMLP_RS12020
uniprot id: M1XT95
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

268739:NMLP RS09050
gene id: 268739:NMLP_RS09050
uniprot id: M1XRZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

268739:NMLP RS02895
gene id: 268739:NMLP_RS02895
uniprot id: M1XKF3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

268739:NMLP RS05530
gene id: 268739:NMLP_RS05530
uniprot id: M1XQD5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

268739:NMLP RS07715
gene id: 268739:NMLP_RS07715
uniprot id: M1XRF0
names: Similarity
messages: Belongs to the MoaB/Mog family.

268739:NMLP RS08565
gene id: 268739:NMLP_RS08565
uniprot id: M1XRT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

268739:NMLP RS08105
gene id: 268739:NMLP_RS08105
uniprot id: M1XRH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

268739:NMLP RS09895
gene id: 268739:NMLP_RS09895
uniprot id: M1XL77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

268739:NMLP RS01885
gene id: 268739:NMLP_RS01885
uniprot id: M1XNP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

268739:NMLP RS13025
gene id: 268739:NMLP_RS13025
uniprot id: M1XTU5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

268739:NMLP RS05235
gene id: 268739:NMLP_RS05235
uniprot id: M1XQ76
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

268739:NMLP RS05815
gene id: 268739:NMLP_RS05815
uniprot id: M1XQL3
names: Function
messages: Part of a potassium transport system.

268739:NMLP RS12870
gene id: 268739:NMLP_RS12870
uniprot id: M1Y5I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

268739:NMLP RS10840
gene id: 268739:NMLP_RS10840
uniprot id: M1XSQ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

268739:NMLP RS02875
gene id: 268739:NMLP_RS02875
uniprot id: M1XP56
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

268739:NMLP RS10400
gene id: 268739:NMLP_RS10400
uniprot id: M1XSK7
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS04965
gene id: 268739:NMLP_RS04965
uniprot id: M1Y144
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS13650
gene id: 268739:NMLP_RS13650
uniprot id: M1XU49
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS06490
gene id: 268739:NMLP_RS06490
uniprot id: M1XKU5
names: Similarity
messages: Belongs to the HAM1 NTPase family.

268739:NMLP RS11780
gene id: 268739:NMLP_RS11780
uniprot id: M1XT59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

268739:NMLP RS00540
gene id: 268739:NMLP_RS00540
uniprot id: M1XN41
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Tetramer of two components I and two components II.

268739:NMLP RS04910
gene id: 268739:NMLP_RS04910
uniprot id: M1Y144
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS01070
gene id: 268739:NMLP_RS01070
uniprot id: M1XZ49
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

268739:NMLP RS02195
gene id: 268739:NMLP_RS02195
uniprot id: M1XNV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

268739:NMLP RS08350
gene id: 268739:NMLP_RS08350
uniprot id: M1Y328
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

268739:NMLP RS15820
gene id: 268739:NMLP_RS15820
uniprot id: M1XKT0
names: Subcellular Location Annotation
messages: Nucleus

268739:NMLP RS13200
gene id: 268739:NMLP_RS13200
uniprot id: M1XTX9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

268739:NMLP RS12315
gene id: 268739:NMLP_RS12315
uniprot id: M1XLH3
names: Similarity
messages: Belongs to the peptidase S49 family.

268739:NMLP RS10200
gene id: 268739:NMLP_RS10200
uniprot id: M1XSE1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

268739:NMLP RS01300
gene id: 268739:NMLP_RS01300
uniprot id: M1XNH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

268739:NMLP RS03630
gene id: 268739:NMLP_RS03630
uniprot id: M1XPM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gas vesicle protein type A family.
messages: Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure.
messages: gas vesicle membrane

268739:NMLP RS02235
gene id: 268739:NMLP_RS02235
uniprot id: M1XNU5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS09360
gene id: 268739:NMLP_RS09360
uniprot id: M1XL56
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

268739:NMLP RS05740
gene id: 268739:NMLP_RS05740
uniprot id: M1XKR6
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

268739:NMLP RS13090
gene id: 268739:NMLP_RS13090
uniprot id: M1XTR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

268739:NMLP RS04265
gene id: 268739:NMLP_RS04265
uniprot id: M1XPS2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

268739:NMLP RS07770
gene id: 268739:NMLP_RS07770
uniprot id: M1XRF8
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS00270
gene id: 268739:NMLP_RS00270
uniprot id: M1XN13
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

268739:NMLP RS00635
gene id: 268739:NMLP_RS00635
uniprot id: M1XK64
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS06730
gene id: 268739:NMLP_RS06730
uniprot id: M1XR08
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

268739:NMLP RS11825
gene id: 268739:NMLP_RS11825
uniprot id: M1XT93
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS05580
gene id: 268739:NMLP_RS05580
uniprot id: M1XQE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

268739:NMLP RS09855
gene id: 268739:NMLP_RS09855
uniprot id: M1Y3W1
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS04695
gene id: 268739:NMLP_RS04695
uniprot id: M1Y104
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

268739:NMLP RS09480
gene id: 268739:NMLP_RS09480
uniprot id: M1XS49
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

268739:NMLP RS11815
gene id: 268739:NMLP_RS11815
uniprot id: M1Y500
names: Function
messages: Part of a potassium transport system.

268739:NMLP RS11320
gene id: 268739:NMLP_RS11320
uniprot id: M1XSY6
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

268739:NMLP RS05515
gene id: 268739:NMLP_RS05515
uniprot id: M1XQG7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

268739:NMLP RS13695
gene id: 268739:NMLP_RS13695
uniprot id: M1XU55
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

268739:NMLP RS06040
gene id: 268739:NMLP_RS06040
uniprot id: M1Y1T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

268739:NMLP RS12150
gene id: 268739:NMLP_RS12150
uniprot id: M1XTB5
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.

268739:NMLP RS04205
gene id: 268739:NMLP_RS04205
uniprot id: M1Y0R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

268739:NMLP RS10025
gene id: 268739:NMLP_RS10025
uniprot id: M1Y3Z9
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

268739:NMLP RS01535
gene id: 268739:NMLP_RS01535
uniprot id: M1XNK2
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

268739:NMLP RS08970
gene id: 268739:NMLP_RS08970
uniprot id: M1XL42
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

268739:NMLP RS10205
gene id: 268739:NMLP_RS10205
uniprot id: M1XL89
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS04105
gene id: 268739:NMLP_RS04105
uniprot id: M1Y0P6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

268739:NMLP RS11955
gene id: 268739:NMLP_RS11955
uniprot id: M1XLF8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

268739:NMLP RS07780
gene id: 268739:NMLP_RS07780
uniprot id: M1XKZ5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

268739:NMLP RS07725
gene id: 268739:NMLP_RS07725
uniprot id: M1XKZ3
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

268739:NMLP RS04125
gene id: 268739:NMLP_RS04125
uniprot id: M1XPR0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS08685
gene id: 268739:NMLP_RS08685
uniprot id: M1XRW1
names: Subcellular Location Annotation
messages: Membrane

268739:NMLP RS09910
gene id: 268739:NMLP_RS09910
uniprot id: M1XSC6
names: Similarity
messages: Belongs to the asparaginase 1 family.

268739:NMLP RS13825
gene id: 268739:NMLP_RS13825
uniprot id: M1XU33
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

268739:NMLP RS10540
gene id: 268739:NMLP_RS10540
uniprot id: M1XLA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

268739:NMLP RS12080
gene id: 268739:NMLP_RS12080
uniprot id: M1XTA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the halobacterial S-layer protein family.
messages: Cell membrane
messages: Membrane
messages: S-layer

268739:NMLP RS00775
gene id: 268739:NMLP_RS00775
uniprot id: M1XNA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

268739:NMLP RS00110
gene id: 268739:NMLP_RS00110
uniprot id: M1XYP1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

268739:NMLP RS03915
gene id: 268739:NMLP_RS03915
uniprot id: M1XPM1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

268739:NMLP RS11015
gene id: 268739:NMLP_RS11015
uniprot id: M1XLC1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

268739:NMLP RS08210
gene id: 268739:NMLP_RS08210
uniprot id: M1XRM1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

268739:NMLP RS12400
gene id: 268739:NMLP_RS12400
uniprot id: M1XTF3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

268739:NMLP RS10050
gene id: 268739:NMLP_RS10050
uniprot id: M1XSC1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS01050
gene id: 268739:NMLP_RS01050
uniprot id: M1XNE3
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

268739:NMLP RS04985
gene id: 268739:NMLP_RS04985
uniprot id: M1Y158
names: Similarity
messages: Belongs to the TrpF family.

268739:NMLP RS11715
gene id: 268739:NMLP_RS11715
uniprot id: M1Y4Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

268739:NMLP RS09005
gene id: 268739:NMLP_RS09005
uniprot id: M1Y3G9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS04750
gene id: 268739:NMLP_RS04750
uniprot id: M1XQ06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

268739:NMLP RS00170
gene id: 268739:NMLP_RS00170
uniprot id: M1XMZ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

268739:NMLP RS08310
gene id: 268739:NMLP_RS08310
uniprot id: M1XL16
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

268739:NMLP RS10285
gene id: 268739:NMLP_RS10285
uniprot id: M1XL92
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

268739:NMLP RS04185
gene id: 268739:NMLP_RS04185
uniprot id: M1XPV7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

268739:NMLP RS05805
gene id: 268739:NMLP_RS05805
uniprot id: M1XQI3
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

268739:NMLP RS06085
gene id: 268739:NMLP_RS06085
uniprot id: M1XQM4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

268739:NMLP RS08775
gene id: 268739:NMLP_RS08775
uniprot id: M1XL34
names: Similarity
messages: Belongs to the phosphohexose mutase family.

268739:NMLP RS06985
gene id: 268739:NMLP_RS06985
uniprot id: M1XR10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

268739:NMLP RS04835
gene id: 268739:NMLP_RS04835
uniprot id: M1Y129
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.