259564:MBUR RS02865
gene id: 259564:MBUR_RS02865
uniprot id: Q12YD7
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

259564:MBUR RS06710
gene id: 259564:MBUR_RS06710
uniprot id: Q12WF2
names: Similarity
messages: Belongs to the CutA family.

259564:MBUR RS02610
gene id: 259564:MBUR_RS02610
uniprot id: Q12YH9
names: Similarity
messages: Belongs to the DMRL synthase family.

259564:MBUR RS05350
gene id: 259564:MBUR_RS05350
uniprot id: Q12X52
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

259564:MBUR RS11815
gene id: 259564:MBUR_RS11815
uniprot id: Q12TT0
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS05160
gene id: 259564:MBUR_RS05160
uniprot id: Q12X87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

259564:MBUR RS02650
gene id: 259564:MBUR_RS02650
uniprot id: Q12YH1
names: Similarity
messages: Belongs to the catalase family.

259564:MBUR RS10900
gene id: 259564:MBUR_RS10900
uniprot id: Q12U93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.

259564:MBUR RS10850
gene id: 259564:MBUR_RS10850
uniprot id: Q12UA3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

259564:MBUR RS02425
gene id: 259564:MBUR_RS02425
uniprot id: Q12YL4
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS06525
gene id: 259564:MBUR_RS06525
uniprot id: Q12WI6
names: Cofactor
messages: Binds 1 zinc ion per subunit.

259564:MBUR RS12040
gene id: 259564:MBUR_RS12040
uniprot id: Q12TP7
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS12320
gene id: 259564:MBUR_RS12320
uniprot id: Q12TK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

259564:MBUR RS10570
gene id: 259564:MBUR_RS10570
uniprot id: Q12UF5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

259564:MBUR RS05950
gene id: 259564:MBUR_RS05950
uniprot id: Q12WU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cell membrane
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Membrane
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

259564:MBUR RS08380
gene id: 259564:MBUR_RS08380
uniprot id: Q12VJ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

259564:MBUR RS07860
gene id: 259564:MBUR_RS07860
uniprot id: Q12VU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

259564:MBUR RS00985
gene id: 259564:MBUR_RS00985
uniprot id: Q12ZC4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

259564:MBUR RS00455
gene id: 259564:MBUR_RS00455
uniprot id: Q12ZL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm

259564:MBUR RS00135
gene id: 259564:MBUR_RS00135
uniprot id: Q12ZS6
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS02605
gene id: 259564:MBUR_RS02605
uniprot id: Q12YI0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

259564:MBUR RS01005
gene id: 259564:MBUR_RS01005
uniprot id: Q12ZC0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

259564:MBUR RS04505
gene id: 259564:MBUR_RS04505
uniprot id: Q12XK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

259564:MBUR RS05365
gene id: 259564:MBUR_RS05365
uniprot id: Q12X49
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

259564:MBUR RS00195
gene id: 259564:MBUR_RS00195
uniprot id: Q12ZR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

259564:MBUR RS03875
gene id: 259564:MBUR_RS03875
uniprot id: Q12XW1
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

259564:MBUR RS06550
gene id: 259564:MBUR_RS06550
uniprot id: Q12WI1
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS08515
gene id: 259564:MBUR_RS08515
uniprot id: Q12VH3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

259564:MBUR RS08090
gene id: 259564:MBUR_RS08090
uniprot id: Q12VQ3
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

259564:MBUR RS08930
gene id: 259564:MBUR_RS08930
uniprot id: Q12VA2
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

259564:MBUR RS12560
gene id: 259564:MBUR_RS12560
uniprot id: Q12TF8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

259564:MBUR RS00045
gene id: 259564:MBUR_RS00045
uniprot id: Q12ZU4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

259564:MBUR RS04710
gene id: 259564:MBUR_RS04710
uniprot id: Q12XG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

259564:MBUR RS11785
gene id: 259564:MBUR_RS11785
uniprot id: Q12TT6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

259564:MBUR RS01765
gene id: 259564:MBUR_RS01765
uniprot id: Q12YY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

259564:MBUR RS04305
gene id: 259564:MBUR_RS04305
uniprot id: Q12XN4
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS05795
gene id: 259564:MBUR_RS05795
uniprot id: Q12WX5
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

259564:MBUR RS00060
gene id: 259564:MBUR_RS00060
uniprot id: Q12ZU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

259564:MBUR RS06035
gene id: 259564:MBUR_RS06035
uniprot id: Q12WS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

259564:MBUR RS08975
gene id: 259564:MBUR_RS08975
uniprot id: Q12V94
names: Similarity
messages: Belongs to the serpin family.

259564:MBUR RS09235
gene id: 259564:MBUR_RS09235
uniprot id: Q12V54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

259564:MBUR RS08325
gene id: 259564:MBUR_RS08325
uniprot id: Q12VK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

259564:MBUR RS00520
gene id: 259564:MBUR_RS00520
uniprot id: Q12ZK7
names: Subcellular Location Annotation
messages: Cytoplasm

259564:MBUR RS01140
gene id: 259564:MBUR_RS01140
uniprot id: Q12Z92
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

259564:MBUR RS02150
gene id: 259564:MBUR_RS02150
uniprot id: Q12YR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

259564:MBUR RS03510
gene id: 259564:MBUR_RS03510
uniprot id: Q12Y24
names: Cofactor
names: Similarity
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.

259564:MBUR RS12515
gene id: 259564:MBUR_RS12515
uniprot id: Q12TG6
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS11775
gene id: 259564:MBUR_RS11775
uniprot id: Q12TT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

259564:MBUR RS07175
gene id: 259564:MBUR_RS07175
uniprot id: Q12W69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).

259564:MBUR RS09955
gene id: 259564:MBUR_RS09955
uniprot id: Q12UR9
names: Subcellular Location Annotation
messages: Cell membrane

259564:MBUR RS09230
gene id: 259564:MBUR_RS09230
uniprot id: Q12V55
names: Subcellular Location Annotation
messages: Cell membrane

259564:MBUR RS02590
gene id: 259564:MBUR_RS02590
uniprot id: Q12YI4
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS10360
gene id: 259564:MBUR_RS10360
uniprot id: Q12UJ5
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

259564:MBUR RS11855
gene id: 259564:MBUR_RS11855
uniprot id: Q12TS7
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS06530
gene id: 259564:MBUR_RS06530
uniprot id: Q12WI5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS04700
gene id: 259564:MBUR_RS04700
uniprot id: Q12XG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

259564:MBUR RS09285
gene id: 259564:MBUR_RS09285
uniprot id: Q12V44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

259564:MBUR RS03580
gene id: 259564:MBUR_RS03580
uniprot id: Q12Y12
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS03840
gene id: 259564:MBUR_RS03840
uniprot id: Q12XW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

259564:MBUR RS02340
gene id: 259564:MBUR_RS02340
uniprot id: Q12YN0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

259564:MBUR RS02550
gene id: 259564:MBUR_RS02550
uniprot id: Q12YJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

259564:MBUR RS08125
gene id: 259564:MBUR_RS08125
uniprot id: Q12VP6
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS00690
gene id: 259564:MBUR_RS00690
uniprot id: Q12ZH6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS02285
gene id: 259564:MBUR_RS02285
uniprot id: Q12YN9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

259564:MBUR RS08925
gene id: 259564:MBUR_RS08925
uniprot id: Q12VA3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

259564:MBUR RS12280
gene id: 259564:MBUR_RS12280
uniprot id: Q12TL0
names: Similarity
messages: Belongs to the TrpF family.

259564:MBUR RS12365
gene id: 259564:MBUR_RS12365
uniprot id: Q12TJ3
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

259564:MBUR RS08055
gene id: 259564:MBUR_RS08055
uniprot id: Q12VR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

259564:MBUR RS07285
gene id: 259564:MBUR_RS07285
uniprot id: Q12W50
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS04360
gene id: 259564:MBUR_RS04360
uniprot id: Q12XM8
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

259564:MBUR RS01460
gene id: 259564:MBUR_RS01460
uniprot id: Q12Z33
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

259564:MBUR RS04260
gene id: 259564:MBUR_RS04260
uniprot id: Q12XP3
names: Similarity
messages: Belongs to the UPF0237 family.

259564:MBUR RS00030
gene id: 259564:MBUR_RS00030
uniprot id: Q12ZU7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

259564:MBUR RS06060
gene id: 259564:MBUR_RS06060
uniprot id: Q12WS4
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

259564:MBUR RS06045
gene id: 259564:MBUR_RS06045
uniprot id: Q12WS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

259564:MBUR RS09615
gene id: 259564:MBUR_RS09615
uniprot id: Q12UY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

259564:MBUR RS00055
gene id: 259564:MBUR_RS00055
uniprot id: Q12ZU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

259564:MBUR RS03625
gene id: 259564:MBUR_RS03625
uniprot id: Q12Y03
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

259564:MBUR RS06745
gene id: 259564:MBUR_RS06745
uniprot id: Q12WE6
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

259564:MBUR RS02890
gene id: 259564:MBUR_RS02890
uniprot id: Q12YD3
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

259564:MBUR RS01550
gene id: 259564:MBUR_RS01550
uniprot id: Q12Z17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

259564:MBUR RS06865
gene id: 259564:MBUR_RS06865
uniprot id: Q12WC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

259564:MBUR RS08715
gene id: 259564:MBUR_RS08715
uniprot id: Q12VE2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

259564:MBUR RS03610
gene id: 259564:MBUR_RS03610
uniprot id: Q12Y06
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.

259564:MBUR RS00580
gene id: 259564:MBUR_RS00580
uniprot id: Q12ZJ5
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

259564:MBUR RS00395
gene id: 259564:MBUR_RS00395
uniprot id: Q12ZM7
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS07815
gene id: 259564:MBUR_RS07815
uniprot id: Q12VV3
names: Similarity
messages: Belongs to the HdrC family.

259564:MBUR RS05435
gene id: 259564:MBUR_RS05435
uniprot id: Q12X37
names: Cofactor
names: Similarity
messages: Belongs to the GARS family.
messages: Binds 2 magnesium or manganese ions per subunit.

259564:MBUR RS00945
gene id: 259564:MBUR_RS00945
uniprot id: Q12ZD2
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

259564:MBUR RS10005
gene id: 259564:MBUR_RS10005
uniprot id: Q12UQ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

259564:MBUR RS07325
gene id: 259564:MBUR_RS07325
uniprot id: Q12W44
names: Similarity
messages: Belongs to the MoaB/Mog family.

259564:MBUR RS02780
gene id: 259564:MBUR_RS02780
uniprot id: Q12YF2
names: Function
messages: Part of a potassium transport system.

259564:MBUR RS00815
gene id: 259564:MBUR_RS00815
uniprot id: Q12ZF6
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS09720
gene id: 259564:MBUR_RS09720
uniprot id: Q12UW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

259564:MBUR RS01735
gene id: 259564:MBUR_RS01735
uniprot id: Q12YZ0
names: Subcellular Location Annotation
messages: Cell membrane

259564:MBUR RS00720
gene id: 259564:MBUR_RS00720
uniprot id: Q12ZH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

259564:MBUR RS11260
gene id: 259564:MBUR_RS11260
uniprot id: Q12U30
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

259564:MBUR RS06860
gene id: 259564:MBUR_RS06860
uniprot id: Q12WC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

259564:MBUR RS03975
gene id: 259564:MBUR_RS03975
uniprot id: Q12XU7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.

259564:MBUR RS05690
gene id: 259564:MBUR_RS05690
uniprot id: Q12WZ3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

259564:MBUR RS09950
gene id: 259564:MBUR_RS09950
uniprot id: Q12US0
names: Subcellular Location Annotation
messages: Cell membrane

259564:MBUR RS08890
gene id: 259564:MBUR_RS08890
uniprot id: Q12VB0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

259564:MBUR RS07960
gene id: 259564:MBUR_RS07960
uniprot id: Q12VS7
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

259564:MBUR RS06690
gene id: 259564:MBUR_RS06690
uniprot id: Q12WF6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: Consists of two subunits, CofG and CofH.

259564:MBUR RS05775
gene id: 259564:MBUR_RS05775
uniprot id: Q12WX9
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

259564:MBUR RS00470
gene id: 259564:MBUR_RS00470
uniprot id: Q12ZL6
names: Function
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

259564:MBUR RS11400
gene id: 259564:MBUR_RS11400
uniprot id: Q12U02
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

259564:MBUR RS08850
gene id: 259564:MBUR_RS08850
uniprot id: Q12VB7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS08230
gene id: 259564:MBUR_RS08230
uniprot id: Q12VM6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

259564:MBUR RS07480
gene id: 259564:MBUR_RS07480
uniprot id: Q12W19
names: Similarity
messages: Belongs to the IMPACT family.

259564:MBUR RS12400
gene id: 259564:MBUR_RS12400
uniprot id: Q12TI7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

259564:MBUR RS12130
gene id: 259564:MBUR_RS12130
uniprot id: Q12TN0
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

259564:MBUR RS00100
gene id: 259564:MBUR_RS00100
uniprot id: Q12ZT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

259564:MBUR RS10365
gene id: 259564:MBUR_RS10365
uniprot id: Q12UJ4
names: Similarity
messages: Belongs to the intimin/invasin family.

259564:MBUR RS10320
gene id: 259564:MBUR_RS10320
uniprot id: Q12UK3
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

259564:MBUR RS10760
gene id: 259564:MBUR_RS10760
uniprot id: Q12UC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
messages: Cell membrane

259564:MBUR RS09905
gene id: 259564:MBUR_RS09905
uniprot id: Q12US9
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS01285
gene id: 259564:MBUR_RS01285
uniprot id: Q12Z67
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS02745
gene id: 259564:MBUR_RS02745
uniprot id: Q12YF8
names: Similarity
messages: Belongs to the UPF0305 family.

259564:MBUR RS05000
gene id: 259564:MBUR_RS05000
uniprot id: Q12XB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

259564:MBUR RS02135
gene id: 259564:MBUR_RS02135
uniprot id: Q12YR9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

259564:MBUR RS09985
gene id: 259564:MBUR_RS09985
uniprot id: Q12UR3
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

259564:MBUR RS07740
gene id: 259564:MBUR_RS07740
uniprot id: Q12VW7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

259564:MBUR RS08895
gene id: 259564:MBUR_RS08895
uniprot id: Q12VA9
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS07110
gene id: 259564:MBUR_RS07110
uniprot id: Q12W82
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

259564:MBUR RS10815
gene id: 259564:MBUR_RS10815
uniprot id: Q12UB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

259564:MBUR RS00080
gene id: 259564:MBUR_RS00080
uniprot id: Q12ZT7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

259564:MBUR RS07910
gene id: 259564:MBUR_RS07910
uniprot id: Q12VT4
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS09380
gene id: 259564:MBUR_RS09380
uniprot id: Q12V27
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS09360
gene id: 259564:MBUR_RS09360
uniprot id: Q12V31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

259564:MBUR RS07165
gene id: 259564:MBUR_RS07165
uniprot id: Q12W71
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

259564:MBUR RS06010
gene id: 259564:MBUR_RS06010
uniprot id: Q12WT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

259564:MBUR RS09840
gene id: 259564:MBUR_RS09840
uniprot id: Q12UU2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS10580
gene id: 259564:MBUR_RS10580
uniprot id: Q12UF3
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

259564:MBUR RS02725
gene id: 259564:MBUR_RS02725
uniprot id: Q12YG1
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

259564:MBUR RS02585
gene id: 259564:MBUR_RS02585
uniprot id: Q12YI5
names: Similarity
messages: Belongs to the HsdR family.

259564:MBUR RS00350
gene id: 259564:MBUR_RS00350
uniprot id: Q12ZN7
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

259564:MBUR RS11530
gene id: 259564:MBUR_RS11530
uniprot id: Q12TX9
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

259564:MBUR RS07560
gene id: 259564:MBUR_RS07560
uniprot id: Q12W02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

259564:MBUR RS07425
gene id: 259564:MBUR_RS07425
uniprot id: Q12W26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

259564:MBUR RS10680
gene id: 259564:MBUR_RS10680
uniprot id: Q12UD5
names: Subcellular Location Annotation
messages: Cell membrane

259564:MBUR RS06695
gene id: 259564:MBUR_RS06695
uniprot id: Q12WF5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: Consists of two subunits, CofG and CofH.

259564:MBUR RS04960
gene id: 259564:MBUR_RS04960
uniprot id: Q12XC2
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

259564:MBUR RS01605
gene id: 259564:MBUR_RS01605
uniprot id: Q12Z08
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

259564:MBUR RS13080
gene id: 259564:MBUR_RS13080
uniprot id: Q12UQ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

259564:MBUR RS08660
gene id: 259564:MBUR_RS08660
uniprot id: Q12VF2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

259564:MBUR RS07850
gene id: 259564:MBUR_RS07850
uniprot id: Q12VU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

259564:MBUR RS10885
gene id: 259564:MBUR_RS10885
uniprot id: Q12U96
names: Similarity
messages: Belongs to the AAA ATPase family.

259564:MBUR RS04415
gene id: 259564:MBUR_RS04415
uniprot id: Q12XL7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

259564:MBUR RS05420
gene id: 259564:MBUR_RS05420
uniprot id: Q12X40
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

259564:MBUR RS07385
gene id: 259564:MBUR_RS07385
uniprot id: Q12W32
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

259564:MBUR RS00705
gene id: 259564:MBUR_RS00705
uniprot id: Q12ZH3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS10280
gene id: 259564:MBUR_RS10280
uniprot id: Q12UL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

259564:MBUR RS10590
gene id: 259564:MBUR_RS10590
uniprot id: Q12UF1
names: Similarity
messages: Belongs to the SUI1 family.

259564:MBUR RS06830
gene id: 259564:MBUR_RS06830
uniprot id: Q12WD0
names: Subcellular Location Annotation
messages: Cytoplasm

259564:MBUR RS00560
gene id: 259564:MBUR_RS00560
uniprot id: Q12ZJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

259564:MBUR RS10555
gene id: 259564:MBUR_RS10555
uniprot id: Q12UF8
names: Similarity
messages: Belongs to the SAICAR synthetase family.

259564:MBUR RS05345
gene id: 259564:MBUR_RS05345
uniprot id: Q12X53
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

259564:MBUR RS08680
gene id: 259564:MBUR_RS08680
uniprot id: Q12VE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

259564:MBUR RS12135
gene id: 259564:MBUR_RS12135
uniprot id: Q12TM9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

259564:MBUR RS00020
gene id: 259564:MBUR_RS00020
uniprot id: Q12ZU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

259564:MBUR RS10805
gene id: 259564:MBUR_RS10805
uniprot id: Q12UB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

259564:MBUR RS06390
gene id: 259564:MBUR_RS06390
uniprot id: Q12WL0
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

259564:MBUR RS12090
gene id: 259564:MBUR_RS12090
uniprot id: Q12TN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

259564:MBUR RS07420
gene id: 259564:MBUR_RS07420
uniprot id: Q12W27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

259564:MBUR RS00605
gene id: 259564:MBUR_RS00605
uniprot id: Q12ZI9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

259564:MBUR RS03600
gene id: 259564:MBUR_RS03600
uniprot id: Q12Y08
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

259564:MBUR RS06370
gene id: 259564:MBUR_RS06370
uniprot id: Q12WL4
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

259564:MBUR RS01120
gene id: 259564:MBUR_RS01120
uniprot id: Q12Z96
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

259564:MBUR RS05825
gene id: 259564:MBUR_RS05825
uniprot id: Q12WW9
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

259564:MBUR RS00205
gene id: 259564:MBUR_RS00205
uniprot id: Q12ZR3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

259564:MBUR RS04380
gene id: 259564:MBUR_RS04380
uniprot id: Q12XM4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

259564:MBUR RS01015
gene id: 259564:MBUR_RS01015
uniprot id: Q12ZB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

259564:MBUR RS00250
gene id: 259564:MBUR_RS00250
uniprot id: Q12ZQ5
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

259564:MBUR RS10980
gene id: 259564:MBUR_RS10980
uniprot id: Q12U80
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

259564:MBUR RS06040
gene id: 259564:MBUR_RS06040
uniprot id: Q12WS8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

259564:MBUR RS08025
gene id: 259564:MBUR_RS08025
uniprot id: Q12VR5
names: Similarity
messages: Belongs to the thioesterase PaaI family.

259564:MBUR RS10600
gene id: 259564:MBUR_RS10600
uniprot id: Q12UE9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

259564:MBUR RS08800
gene id: 259564:MBUR_RS08800
uniprot id: Q12VC6
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

259564:MBUR RS03635
gene id: 259564:MBUR_RS03635
uniprot id: Q12Y01
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

259564:MBUR RS00355
gene id: 259564:MBUR_RS00355
uniprot id: Q12ZN6
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS00695
gene id: 259564:MBUR_RS00695
uniprot id: Q12ZH5
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS06705
gene id: 259564:MBUR_RS06705
uniprot id: Q12WF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

259564:MBUR RS04515
gene id: 259564:MBUR_RS04515
uniprot id: Q12XK0
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

259564:MBUR RS05910
gene id: 259564:MBUR_RS05910
uniprot id: Q12WV1
names: Similarity
messages: Belongs to the UPF0251 family.

259564:MBUR RS11725
gene id: 259564:MBUR_RS11725
uniprot id: Q12TU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

259564:MBUR RS09880
gene id: 259564:MBUR_RS09880
uniprot id: Q12UT4
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS10010
gene id: 259564:MBUR_RS10010
uniprot id: Q12UQ8
names: Similarity
messages: Belongs to the peptidase S49 family.

259564:MBUR RS12860
gene id: 259564:MBUR_RS12860
uniprot id: Q12Y36
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS06090
gene id: 259564:MBUR_RS06090
uniprot id: Q12WR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

259564:MBUR RS06975
gene id: 259564:MBUR_RS06975
uniprot id: Q12WA4
names: Similarity
messages: Belongs to the FBPase class 2 family.

259564:MBUR RS02270
gene id: 259564:MBUR_RS02270
uniprot id: Q12YP2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

259564:MBUR RS01240
gene id: 259564:MBUR_RS01240
uniprot id: Q12Z73
names: Similarity
messages: Belongs to the DEAD box helicase family.

259564:MBUR RS02520
gene id: 259564:MBUR_RS02520
uniprot id: Q12YJ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS07735
gene id: 259564:MBUR_RS07735
uniprot id: Q12VW8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

259564:MBUR RS00315
gene id: 259564:MBUR_RS00315
uniprot id: Q12ZP3
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

259564:MBUR RS05810
gene id: 259564:MBUR_RS05810
uniprot id: Q12WX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

259564:MBUR RS04610
gene id: 259564:MBUR_RS04610
uniprot id: Q12XI2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS11465
gene id: 259564:MBUR_RS11465
uniprot id: Q12TZ2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

259564:MBUR RS08510
gene id: 259564:MBUR_RS08510
uniprot id: Q12VH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

259564:MBUR RS01420
gene id: 259564:MBUR_RS01420
uniprot id: Q12Z41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

259564:MBUR RS01030
gene id: 259564:MBUR_RS01030
uniprot id: Q12ZB5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

259564:MBUR RS10075
gene id: 259564:MBUR_RS10075
uniprot id: Q12UP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

259564:MBUR RS07495
gene id: 259564:MBUR_RS07495
uniprot id: Q12W15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the threonine synthase family. Cysteate synthase subfamily.
messages: Homotrimer.
messages: Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate.

259564:MBUR RS06345
gene id: 259564:MBUR_RS06345
uniprot id: Q12WL9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

259564:MBUR RS03675
gene id: 259564:MBUR_RS03675
uniprot id: Q12XZ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS09640
gene id: 259564:MBUR_RS09640
uniprot id: Q12UY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.
messages: Monomer and homodimer.

259564:MBUR RS01130
gene id: 259564:MBUR_RS01130
uniprot id: Q12Z94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

259564:MBUR RS02320
gene id: 259564:MBUR_RS02320
uniprot id: Q12YN5
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

259564:MBUR RS05815
gene id: 259564:MBUR_RS05815
uniprot id: Q12WX1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

259564:MBUR RS06365
gene id: 259564:MBUR_RS06365
uniprot id: Q12WL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

259564:MBUR RS06375
gene id: 259564:MBUR_RS06375
uniprot id: Q12WL3
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

259564:MBUR RS01900
gene id: 259564:MBUR_RS01900
uniprot id: Q12YV7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

259564:MBUR RS01315
gene id: 259564:MBUR_RS01315
uniprot id: Q12Z61
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

259564:MBUR RS06750
gene id: 259564:MBUR_RS06750
uniprot id: Q12WE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

259564:MBUR RS03115
gene id: 259564:MBUR_RS03115
uniprot id: Q12Y92
names: Function
names: Subcellular Location Annotation
messages: Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-exporting P-type ATPase A (CopA).
messages: Cytoplasm

259564:MBUR RS04110
gene id: 259564:MBUR_RS04110
uniprot id: Q12XS0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

259564:MBUR RS09365
gene id: 259564:MBUR_RS09365
uniprot id: Q12V30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

259564:MBUR RS08145
gene id: 259564:MBUR_RS08145
uniprot id: Q12VP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

259564:MBUR RS10785
gene id: 259564:MBUR_RS10785
uniprot id: Q12UB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
messages: Cytoplasm

259564:MBUR RS07125
gene id: 259564:MBUR_RS07125
uniprot id: Q12W79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

259564:MBUR RS07185
gene id: 259564:MBUR_RS07185
uniprot id: Q12W67
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

259564:MBUR RS00600
gene id: 259564:MBUR_RS00600
uniprot id: Q12ZJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

259564:MBUR RS00225
gene id: 259564:MBUR_RS00225
uniprot id: Q12ZR2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS00190
gene id: 259564:MBUR_RS00190
uniprot id: Q12ZR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

259564:MBUR RS07350
gene id: 259564:MBUR_RS07350
uniprot id: Q12W39
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS10940
gene id: 259564:MBUR_RS10940
uniprot id: Q12U87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

259564:MBUR RS05530
gene id: 259564:MBUR_RS05530
uniprot id: Q12X21
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

259564:MBUR RS07935
gene id: 259564:MBUR_RS07935
uniprot id: Q12VT1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

259564:MBUR RS06105
gene id: 259564:MBUR_RS06105
uniprot id: Q12WR6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS05885
gene id: 259564:MBUR_RS05885
uniprot id: Q12WV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

259564:MBUR RS12405
gene id: 259564:MBUR_RS12405
uniprot id: Q12TI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

259564:MBUR RS05525
gene id: 259564:MBUR_RS05525
uniprot id: Q12X22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

259564:MBUR RS04095
gene id: 259564:MBUR_RS04095
uniprot id: Q12XS3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

259564:MBUR RS09280
gene id: 259564:MBUR_RS09280
uniprot id: Q12V45
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS10225
gene id: 259564:MBUR_RS10225
uniprot id: Q12UM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

259564:MBUR RS01280
gene id: 259564:MBUR_RS01280
uniprot id: Q12Z68
names: Similarity
messages: Belongs to the class-I fumarase family.

259564:MBUR RS06330
gene id: 259564:MBUR_RS06330
uniprot id: Q12WM2
names: Similarity
messages: Belongs to the Ahb/Nir family.

259564:MBUR RS02955
gene id: 259564:MBUR_RS02955
uniprot id: Q12YC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

259564:MBUR RS05315
gene id: 259564:MBUR_RS05315
uniprot id: Q12X59
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

259564:MBUR RS05355
gene id: 259564:MBUR_RS05355
uniprot id: Q12X51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity).
messages: Homodimer.

259564:MBUR RS12260
gene id: 259564:MBUR_RS12260
uniprot id: Q12TL3
names: Caution
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS10110
gene id: 259564:MBUR_RS10110
uniprot id: Q12UP0
names: Similarity
messages: Belongs to the AAA ATPase family.

259564:MBUR RS06075
gene id: 259564:MBUR_RS06075
uniprot id: Q12WS2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

259564:MBUR RS11790
gene id: 259564:MBUR_RS11790
uniprot id: Q12TT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

259564:MBUR RS06465
gene id: 259564:MBUR_RS06465
uniprot id: Q12WJ7
names: Similarity
messages: Belongs to the PspA/IM30 family.

259564:MBUR RS04490
gene id: 259564:MBUR_RS04490
uniprot id: Q12XK4
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS00570
gene id: 259564:MBUR_RS00570
uniprot id: Q12ZJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

259564:MBUR RS00970
gene id: 259564:MBUR_RS00970
uniprot id: Q12ZC7
names: Similarity
messages: Belongs to the ZPR1 family.

259564:MBUR RS00730
gene id: 259564:MBUR_RS00730
uniprot id: Q12ZG8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

259564:MBUR RS04760
gene id: 259564:MBUR_RS04760
uniprot id: Q12XF4
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

259564:MBUR RS01635
gene id: 259564:MBUR_RS01635
uniprot id: Q12Z05
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

259564:MBUR RS07335
gene id: 259564:MBUR_RS07335
uniprot id: Q12W42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

259564:MBUR RS10065
gene id: 259564:MBUR_RS10065
uniprot id: Q12UP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

259564:MBUR RS09335
gene id: 259564:MBUR_RS09335
uniprot id: Q12V36
names: Similarity
messages: Belongs to the band 7/mec-2 family.

259564:MBUR RS02675
gene id: 259564:MBUR_RS02675
uniprot id: Q12YG8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

259564:MBUR RS02145
gene id: 259564:MBUR_RS02145
uniprot id: Q12YR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

259564:MBUR RS08910
gene id: 259564:MBUR_RS08910
uniprot id: Q12VA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

259564:MBUR RS04050
gene id: 259564:MBUR_RS04050
uniprot id: Q12XT3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

259564:MBUR RS04530
gene id: 259564:MBUR_RS04530
uniprot id: Q12XJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

259564:MBUR RS00335
gene id: 259564:MBUR_RS00335
uniprot id: Q12ZP0
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

259564:MBUR RS00975
gene id: 259564:MBUR_RS00975
uniprot id: Q12ZC6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

259564:MBUR RS07970
gene id: 259564:MBUR_RS07970
uniprot id: Q12VS5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS08765
gene id: 259564:MBUR_RS08765
uniprot id: Q12VD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

259564:MBUR RS01985
gene id: 259564:MBUR_RS01985
uniprot id: Q12YU2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

259564:MBUR RS07835
gene id: 259564:MBUR_RS07835
uniprot id: Q12VU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

259564:MBUR RS01925
gene id: 259564:MBUR_RS01925
uniprot id: Q12YV2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS09730
gene id: 259564:MBUR_RS09730
uniprot id: Q12UW3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS07855
gene id: 259564:MBUR_RS07855
uniprot id: Q12VU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

259564:MBUR RS06290
gene id: 259564:MBUR_RS06290
uniprot id: Q12WN0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

259564:MBUR RS09965
gene id: 259564:MBUR_RS09965
uniprot id: Q12UR7
names: Similarity
messages: Belongs to the PurH family.

259564:MBUR RS08205
gene id: 259564:MBUR_RS08205
uniprot id: Q12VN1
names: Similarity
messages: Belongs to the polysaccharide synthase family.

259564:MBUR RS07905
gene id: 259564:MBUR_RS07905
uniprot id: Q12VT5
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS04390
gene id: 259564:MBUR_RS04390
uniprot id: Q12XM2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS12125
gene id: 259564:MBUR_RS12125
uniprot id: Q12TN1
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

259564:MBUR RS00200
gene id: 259564:MBUR_RS00200
uniprot id: Q12ZR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

259564:MBUR RS11295
gene id: 259564:MBUR_RS11295
uniprot id: Q12U23
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

259564:MBUR RS05545
gene id: 259564:MBUR_RS05545
uniprot id: Q12X18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

259564:MBUR RS11395
gene id: 259564:MBUR_RS11395
uniprot id: Q12U03
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

259564:MBUR RS11695
gene id: 259564:MBUR_RS11695
uniprot id: Q12TV2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

259564:MBUR RS02175
gene id: 259564:MBUR_RS02175
uniprot id: Q12YR0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

259564:MBUR RS11145
gene id: 259564:MBUR_RS11145
uniprot id: Q12U50
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

259564:MBUR RS04330
gene id: 259564:MBUR_RS04330
uniprot id: Q12XN1
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS06055
gene id: 259564:MBUR_RS06055
uniprot id: Q12WS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

259564:MBUR RS00475
gene id: 259564:MBUR_RS00475
uniprot id: Q12ZL5
names: Function
names: Similarity
messages: Belongs to the glutamate synthase family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

259564:MBUR RS00760
gene id: 259564:MBUR_RS00760
uniprot id: Q12ZG3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

259564:MBUR RS10060
gene id: 259564:MBUR_RS10060
uniprot id: Q12UQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

259564:MBUR RS10860
gene id: 259564:MBUR_RS10860
uniprot id: Q12UA1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

259564:MBUR RS08300
gene id: 259564:MBUR_RS08300
uniprot id: Q12VL2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

259564:MBUR RS08505
gene id: 259564:MBUR_RS08505
uniprot id: Q12VH5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS01415
gene id: 259564:MBUR_RS01415
uniprot id: Q12Z42
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

259564:MBUR RS01380
gene id: 259564:MBUR_RS01380
uniprot id: Q12Z49
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

259564:MBUR RS06520
gene id: 259564:MBUR_RS06520
uniprot id: Q12WI7
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

259564:MBUR RS02140
gene id: 259564:MBUR_RS02140
uniprot id: Q12YR8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

259564:MBUR RS00575
gene id: 259564:MBUR_RS00575
uniprot id: Q12ZJ6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

259564:MBUR RS02785
gene id: 259564:MBUR_RS02785
uniprot id: Q12YF1
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS10935
gene id: 259564:MBUR_RS10935
uniprot id: Q12U88
names: Similarity
messages: Belongs to the phosphohexose mutase family.

259564:MBUR RS01245
gene id: 259564:MBUR_RS01245
uniprot id: Q12Z72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

259564:MBUR RS01350
gene id: 259564:MBUR_RS01350
uniprot id: Q12Z55
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

259564:MBUR RS01045
gene id: 259564:MBUR_RS01045
uniprot id: Q12ZB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

259564:MBUR RS12465
gene id: 259564:MBUR_RS12465
uniprot id: Q12TH4
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS05215
gene id: 259564:MBUR_RS05215
uniprot id: Q12X76
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS04880
gene id: 259564:MBUR_RS04880
uniprot id: Q12XD7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

259564:MBUR RS10925
gene id: 259564:MBUR_RS10925
uniprot id: Q12U89
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

259564:MBUR RS09345
gene id: 259564:MBUR_RS09345
uniprot id: Q12V34
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

259564:MBUR RS10050
gene id: 259564:MBUR_RS10050
uniprot id: Q12UQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

259564:MBUR RS11405
gene id: 259564:MBUR_RS11405
uniprot id: Q12U01
names: Subunit
messages: Homotetramer.

259564:MBUR RS04835
gene id: 259564:MBUR_RS04835
uniprot id: Q12XE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

259564:MBUR RS06660
gene id: 259564:MBUR_RS06660
uniprot id: Q12WG2
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

259564:MBUR RS04100
gene id: 259564:MBUR_RS04100
uniprot id: Q12XS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

259564:MBUR RS05635
gene id: 259564:MBUR_RS05635
uniprot id: Q12X01
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS11960
gene id: 259564:MBUR_RS11960
uniprot id: Q12TR0
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

259564:MBUR RS09530
gene id: 259564:MBUR_RS09530
uniprot id: Q12V02
names: Similarity
messages: Belongs to the HsdR family.

259564:MBUR RS03475
gene id: 259564:MBUR_RS03475
uniprot id: Q12Y30
names: Similarity
messages: Belongs to the TPP enzyme family.

259564:MBUR RS06300
gene id: 259564:MBUR_RS06300
uniprot id: Q12WM8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

259564:MBUR RS10095
gene id: 259564:MBUR_RS10095
uniprot id: Q12UP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

259564:MBUR RS12255
gene id: 259564:MBUR_RS12255
uniprot id: Q12TL4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

259564:MBUR RS12580
gene id: 259564:MBUR_RS12580
uniprot id: Q12TF4
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

259564:MBUR RS01830
gene id: 259564:MBUR_RS01830
uniprot id: Q12YX1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

259564:MBUR RS05830
gene id: 259564:MBUR_RS05830
uniprot id: Q12WW8
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

259564:MBUR RS00615
gene id: 259564:MBUR_RS00615
uniprot id: Q12ZI7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

259564:MBUR RS10495
gene id: 259564:MBUR_RS10495
uniprot id: Q12UH1
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

259564:MBUR RS11085
gene id: 259564:MBUR_RS11085
uniprot id: Q12U62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ModE family.
messages: Membrane

259564:MBUR RS06150
gene id: 259564:MBUR_RS06150
uniprot id: Q12WQ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

259564:MBUR RS01560
gene id: 259564:MBUR_RS01560
uniprot id: Q12Z15
names: Similarity
messages: Belongs to the UPF0280 family.

259564:MBUR RS00085
gene id: 259564:MBUR_RS00085
uniprot id: Q12ZT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

259564:MBUR RS00285
gene id: 259564:MBUR_RS00285
uniprot id: Q12ZP9
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

259564:MBUR RS08635
gene id: 259564:MBUR_RS08635
uniprot id: Q12VF7
names: Similarity
messages: Belongs to the HisA/HisF family.

259564:MBUR RS08950
gene id: 259564:MBUR_RS08950
uniprot id: Q12V99
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

259564:MBUR RS00110
gene id: 259564:MBUR_RS00110
uniprot id: Q12ZT1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

259564:MBUR RS10210
gene id: 259564:MBUR_RS10210
uniprot id: Q12UM4
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

259564:MBUR RS12265
gene id: 259564:MBUR_RS12265
uniprot id: Q12TL2
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

259564:MBUR RS07840
gene id: 259564:MBUR_RS07840
uniprot id: Q12VU8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

259564:MBUR RS04075
gene id: 259564:MBUR_RS04075
uniprot id: Q12XS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

259564:MBUR RS08785
gene id: 259564:MBUR_RS08785
uniprot id: Q12VC9
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

259564:MBUR RS09680
gene id: 259564:MBUR_RS09680
uniprot id: Q12UX3
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

259564:MBUR RS05630
gene id: 259564:MBUR_RS05630
uniprot id: Q12X02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

259564:MBUR RS08555
gene id: 259564:MBUR_RS08555
uniprot id: Q12VG6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

259564:MBUR RS03980
gene id: 259564:MBUR_RS03980
uniprot id: Q12XU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

259564:MBUR RS12025
gene id: 259564:MBUR_RS12025
uniprot id: Q12TQ0
names: Function
names: Similarity
messages: Belongs to the RuBisCO large chain family. Type II subfamily.
messages: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.

259564:MBUR RS12275
gene id: 259564:MBUR_RS12275
uniprot id: Q12TL1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

259564:MBUR RS08350
gene id: 259564:MBUR_RS08350
uniprot id: Q12VK2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

259564:MBUR RS08645
gene id: 259564:MBUR_RS08645
uniprot id: Q12VF5
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

259564:MBUR RS12440
gene id: 259564:MBUR_RS12440
uniprot id: Q12TH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

259564:MBUR RS11800
gene id: 259564:MBUR_RS11800
uniprot id: Q12TT3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

259564:MBUR RS07120
gene id: 259564:MBUR_RS07120
uniprot id: Q12W80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

259564:MBUR RS04980
gene id: 259564:MBUR_RS04980
uniprot id: Q12XB8
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

259564:MBUR RS08955
gene id: 259564:MBUR_RS08955
uniprot id: Q12V98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

259564:MBUR RS06740
gene id: 259564:MBUR_RS06740
uniprot id: Q12WE7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

259564:MBUR RS12410
gene id: 259564:MBUR_RS12410
uniprot id: Q12TI5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

259564:MBUR RS11160
gene id: 259564:MBUR_RS11160
uniprot id: Q12U47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

259564:MBUR RS08010
gene id: 259564:MBUR_RS08010
uniprot id: Q12VR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

259564:MBUR RS11300
gene id: 259564:MBUR_RS11300
uniprot id: Q12U22
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS12250
gene id: 259564:MBUR_RS12250
uniprot id: Q12TL5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

259564:MBUR RS01020
gene id: 259564:MBUR_RS01020
uniprot id: Q12ZB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

259564:MBUR RS00565
gene id: 259564:MBUR_RS00565
uniprot id: Q12ZJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

259564:MBUR RS02685
gene id: 259564:MBUR_RS02685
uniprot id: Q12YG7
names: Similarity
messages: Belongs to the serpin family.

259564:MBUR RS01800
gene id: 259564:MBUR_RS01800
uniprot id: Q12YX8
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS12140
gene id: 259564:MBUR_RS12140
uniprot id: Q12TM8
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

259564:MBUR RS11805
gene id: 259564:MBUR_RS11805
uniprot id: Q12TT2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit.

259564:MBUR RS08755
gene id: 259564:MBUR_RS08755
uniprot id: Q12VD4
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS12430
gene id: 259564:MBUR_RS12430
uniprot id: Q12TI1
names: Similarity
messages: Belongs to the MEMO1 family.

259564:MBUR RS01300
gene id: 259564:MBUR_RS01300
uniprot id: Q12Z64
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

259564:MBUR RS03640
gene id: 259564:MBUR_RS03640
uniprot id: Q12Y00
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

259564:MBUR RS06385
gene id: 259564:MBUR_RS06385
uniprot id: Q12WL1
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

259564:MBUR RS00550
gene id: 259564:MBUR_RS00550
uniprot id: Q12ZK1
names: Similarity
messages: Belongs to the TrpC family.

259564:MBUR RS10340
gene id: 259564:MBUR_RS10340
uniprot id: Q12UJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

259564:MBUR RS06180
gene id: 259564:MBUR_RS06180
uniprot id: Q12WQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

259564:MBUR RS01040
gene id: 259564:MBUR_RS01040
uniprot id: Q12ZB2
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

259564:MBUR RS10720
gene id: 259564:MBUR_RS10720
uniprot id: Q12UC8
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS01010
gene id: 259564:MBUR_RS01010
uniprot id: Q12ZB9
names: Similarity
messages: Belongs to the SDO1/SBDS family.

259564:MBUR RS12070
gene id: 259564:MBUR_RS12070
uniprot id: Q12TP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

259564:MBUR RS12110
gene id: 259564:MBUR_RS12110
uniprot id: Q12TN4
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

259564:MBUR RS09600
gene id: 259564:MBUR_RS09600
uniprot id: Q12UY9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS04650
gene id: 259564:MBUR_RS04650
uniprot id: Q12XH4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

259564:MBUR RS05565
gene id: 259564:MBUR_RS05565
uniprot id: Q12X14
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

259564:MBUR RS04925
gene id: 259564:MBUR_RS04925
uniprot id: Q12XC8
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

259564:MBUR RS08700
gene id: 259564:MBUR_RS08700
uniprot id: Q12VE4
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

259564:MBUR RS01970
gene id: 259564:MBUR_RS01970
uniprot id: Q12YU4
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS00765
gene id: 259564:MBUR_RS00765
uniprot id: Q12ZG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

259564:MBUR RS10325
gene id: 259564:MBUR_RS10325
uniprot id: Q12UK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

259564:MBUR RS08640
gene id: 259564:MBUR_RS08640
uniprot id: Q12VF6
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

259564:MBUR RS01305
gene id: 259564:MBUR_RS01305
uniprot id: Q12Z63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

259564:MBUR RS11195
gene id: 259564:MBUR_RS11195
uniprot id: Q12U41
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

259564:MBUR RS05680
gene id: 259564:MBUR_RS05680
uniprot id: Q12WZ5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

259564:MBUR RS04280
gene id: 259564:MBUR_RS04280
uniprot id: Q12XN9
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS12215
gene id: 259564:MBUR_RS12215
uniprot id: Q12TM0
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

259564:MBUR RS12535
gene id: 259564:MBUR_RS12535
uniprot id: Q12TG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

259564:MBUR RS12105
gene id: 259564:MBUR_RS12105
uniprot id: Q12TN5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.

259564:MBUR RS10490
gene id: 259564:MBUR_RS10490
uniprot id: Q12UH2
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS11485
gene id: 259564:MBUR_RS11485
uniprot id: Q12TY8
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS10530
gene id: 259564:MBUR_RS10530
uniprot id: Q12UG4
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

259564:MBUR RS10285
gene id: 259564:MBUR_RS10285
uniprot id: Q12UL0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

259564:MBUR RS01715
gene id: 259564:MBUR_RS01715
uniprot id: Q12YZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

259564:MBUR RS05330
gene id: 259564:MBUR_RS05330
uniprot id: Q12X56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

259564:MBUR RS00040
gene id: 259564:MBUR_RS00040
uniprot id: Q12ZU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

259564:MBUR RS02385
gene id: 259564:MBUR_RS02385
uniprot id: Q12YM2
names: Similarity
messages: Belongs to the pyruvate kinase family.

259564:MBUR RS08030
gene id: 259564:MBUR_RS08030
uniprot id: Q12VR4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

259564:MBUR RS04630
gene id: 259564:MBUR_RS04630
uniprot id: Q12XH8
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

259564:MBUR RS12055
gene id: 259564:MBUR_RS12055
uniprot id: Q12TP4
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

259564:MBUR RS02805
gene id: 259564:MBUR_RS02805
uniprot id: Q12YE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

259564:MBUR RS03785
gene id: 259564:MBUR_RS03785
uniprot id: Q12XX4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.
messages: Involved in the biosynthesis of 6-O-methylglucose lipopolysaccarides (MGLPs). Catalyzes the transfer of a glucose (Glc) moiety from uridine diphosphate (UDP-Glc) to the position 2 of 3-phospho-D-glycerate (3-PGA) to form glucosyl-3-phosphoglycerate (GPG).
messages: Requires divalent cations for activity in the following order of efficiency: Mn(2+), Co(2+) and Mg(2+) ions.

259564:MBUR RS06895
gene id: 259564:MBUR_RS06895
uniprot id: Q12WB9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

259564:MBUR RS11275
gene id: 259564:MBUR_RS11275
uniprot id: Q12U27
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

259564:MBUR RS04165
gene id: 259564:MBUR_RS04165
uniprot id: Q12XQ9
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

259564:MBUR RS00595
gene id: 259564:MBUR_RS00595
uniprot id: Q12ZJ1
names: Similarity
messages: Belongs to the PDCD5 family.

259564:MBUR RS05400
gene id: 259564:MBUR_RS05400
uniprot id: Q12X44
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS05320
gene id: 259564:MBUR_RS05320
uniprot id: Q12X58
names: Similarity
messages: Belongs to the UPF0179 family.

259564:MBUR RS00555
gene id: 259564:MBUR_RS00555
uniprot id: Q12ZK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

259564:MBUR RS05155
gene id: 259564:MBUR_RS05155
uniprot id: Q12X88
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS07700
gene id: 259564:MBUR_RS07700
uniprot id: Q12VX5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS07830
gene id: 259564:MBUR_RS07830
uniprot id: Q12VV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

259564:MBUR RS06100
gene id: 259564:MBUR_RS06100
uniprot id: Q12WR7
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

259564:MBUR RS06580
gene id: 259564:MBUR_RS06580
uniprot id: Q12WH6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

259564:MBUR RS12450
gene id: 259564:MBUR_RS12450
uniprot id: Q12TH7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

259564:MBUR RS08310
gene id: 259564:MBUR_RS08310
uniprot id: Q12VL0
names: Similarity
messages: Belongs to the UDPGP type 2 family.

259564:MBUR RS13205
gene id: 259564:MBUR_RS13205
uniprot id: Q12TG1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS06985
gene id: 259564:MBUR_RS06985
uniprot id: Q12WA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

259564:MBUR RS01515
gene id: 259564:MBUR_RS01515
uniprot id: Q12Z24
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

259564:MBUR RS01770
gene id: 259564:MBUR_RS01770
uniprot id: Q12YY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

259564:MBUR RS00280
gene id: 259564:MBUR_RS00280
uniprot id: Q12ZQ0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

259564:MBUR RS00535
gene id: 259564:MBUR_RS00535
uniprot id: Q12ZK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

259564:MBUR RS10945
gene id: 259564:MBUR_RS10945
uniprot id: Q12U86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.

259564:MBUR RS00700
gene id: 259564:MBUR_RS00700
uniprot id: Q12ZH4
names: Similarity
messages: Belongs to the complex I subunit 4 family.

259564:MBUR RS11705
gene id: 259564:MBUR_RS11705
uniprot id: Q12TV0
names: Similarity
messages: Belongs to the LarC family.

259564:MBUR RS10865
gene id: 259564:MBUR_RS10865
uniprot id: Q12UA0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

259564:MBUR RS06900
gene id: 259564:MBUR_RS06900
uniprot id: Q12WB8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

259564:MBUR RS00995
gene id: 259564:MBUR_RS00995
uniprot id: Q12ZC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

259564:MBUR RS06805
gene id: 259564:MBUR_RS06805
uniprot id: Q12WD4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

259564:MBUR RS06585
gene id: 259564:MBUR_RS06585
uniprot id: Q12WH5
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

259564:MBUR RS00175
gene id: 259564:MBUR_RS00175
uniprot id: Q12ZR9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

259564:MBUR RS01945
gene id: 259564:MBUR_RS01945
uniprot id: Q12YU9
names: Similarity
messages: Belongs to the UPF0758 family.

259564:MBUR RS11320
gene id: 259564:MBUR_RS11320
uniprot id: Q12U18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

259564:MBUR RS11525
gene id: 259564:MBUR_RS11525
uniprot id: Q12TY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

259564:MBUR RS03225
gene id: 259564:MBUR_RS03225
uniprot id: Q12Y70
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS00770
gene id: 259564:MBUR_RS00770
uniprot id: Q12ZG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

259564:MBUR RS02525
gene id: 259564:MBUR_RS02525
uniprot id: Q12YJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

259564:MBUR RS02845
gene id: 259564:MBUR_RS02845
uniprot id: Q12YE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

259564:MBUR RS00115
gene id: 259564:MBUR_RS00115
uniprot id: Q12ZT0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

259564:MBUR RS08280
gene id: 259564:MBUR_RS08280
uniprot id: Q12VL6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

259564:MBUR RS10200
gene id: 259564:MBUR_RS10200
uniprot id: Q12UM5
names: Similarity
messages: Belongs to the UPF0235 family.

259564:MBUR RS06850
gene id: 259564:MBUR_RS06850
uniprot id: Q12WC8
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

259564:MBUR RS01135
gene id: 259564:MBUR_RS01135
uniprot id: Q12Z93
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

259564:MBUR RS03555
gene id: 259564:MBUR_RS03555
uniprot id: Q12Y17
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS12640
gene id: 259564:MBUR_RS12640
uniprot id: Q12TE2
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

259564:MBUR RS08935
gene id: 259564:MBUR_RS08935
uniprot id: Q12VA1
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

259564:MBUR RS11370
gene id: 259564:MBUR_RS11370
uniprot id: Q12U08
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

259564:MBUR RS00035
gene id: 259564:MBUR_RS00035
uniprot id: Q12ZU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

259564:MBUR RS03315
gene id: 259564:MBUR_RS03315
uniprot id: Q12Y52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
messages: Cytoplasm

259564:MBUR RS12550
gene id: 259564:MBUR_RS12550
uniprot id: Q12TF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

259564:MBUR RS11350
gene id: 259564:MBUR_RS11350
uniprot id: Q12U12
names: Similarity
messages: Belongs to the ClpA/ClpB family.

259564:MBUR RS13070
gene id: 259564:MBUR_RS13070
uniprot id: Q12V01
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

259564:MBUR RS10635
gene id: 259564:MBUR_RS10635
uniprot id: Q12UE2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS10145
gene id: 259564:MBUR_RS10145
uniprot id: Q12UN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

259564:MBUR RS07745
gene id: 259564:MBUR_RS07745
uniprot id: Q12VW6
names: Similarity
messages: Belongs to the archaeal-type GPI family.

259564:MBUR RS11325
gene id: 259564:MBUR_RS11325
uniprot id: Q12U17
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

259564:MBUR RS09900
gene id: 259564:MBUR_RS09900
uniprot id: Q12UT0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

259564:MBUR RS05270
gene id: 259564:MBUR_RS05270
uniprot id: Q12X68
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS02580
gene id: 259564:MBUR_RS02580
uniprot id: Q12YI6
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

259564:MBUR RS09385
gene id: 259564:MBUR_RS09385
uniprot id: Q12V26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

259564:MBUR RS05440
gene id: 259564:MBUR_RS05440
uniprot id: Q12X36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

259564:MBUR RS09265
gene id: 259564:MBUR_RS09265
uniprot id: Q12V48
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

259564:MBUR RS11930
gene id: 259564:MBUR_RS11930
uniprot id: Q12TR5
names: Similarity
messages: Belongs to the DNA photolyase family.

259564:MBUR RS05800
gene id: 259564:MBUR_RS05800
uniprot id: Q12WX4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

259564:MBUR RS11075
gene id: 259564:MBUR_RS11075
uniprot id: Q12U64
names: Similarity
messages: Belongs to the UPF0251 family.

259564:MBUR RS06305
gene id: 259564:MBUR_RS06305
uniprot id: Q12WM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

259564:MBUR RS05465
gene id: 259564:MBUR_RS05465
uniprot id: Q12X32
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

259564:MBUR RS10950
gene id: 259564:MBUR_RS10950
uniprot id: Q12U85
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

259564:MBUR RS12435
gene id: 259564:MBUR_RS12435
uniprot id: Q12TI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

259564:MBUR RS08005
gene id: 259564:MBUR_RS08005
uniprot id: Q12VR9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS07845
gene id: 259564:MBUR_RS07845
uniprot id: Q12VU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

259564:MBUR RS06260
gene id: 259564:MBUR_RS06260
uniprot id: Q12WN6
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

259564:MBUR RS01910
gene id: 259564:MBUR_RS01910
uniprot id: Q12YV5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

259564:MBUR RS00435
gene id: 259564:MBUR_RS00435
uniprot id: Q12ZM1
names: Similarity
messages: Belongs to the SfsA family.

259564:MBUR RS03845
gene id: 259564:MBUR_RS03845
uniprot id: Q12XW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

259564:MBUR RS06080
gene id: 259564:MBUR_RS06080
uniprot id: Q12WS1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

259564:MBUR RS10085
gene id: 259564:MBUR_RS10085
uniprot id: Q12UP5
names: Similarity
messages: Belongs to the DEAD box helicase family.

259564:MBUR RS03120
gene id: 259564:MBUR_RS03120
uniprot id: Q12Y91
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

259564:MBUR RS10640
gene id: 259564:MBUR_RS10640
uniprot id: Q12UE1
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS06610
gene id: 259564:MBUR_RS06610
uniprot id: Q12WH0
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS05125
gene id: 259564:MBUR_RS05125
uniprot id: Q12X92
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

259564:MBUR RS00105
gene id: 259564:MBUR_RS00105
uniprot id: Q12ZT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

259564:MBUR RS10295
gene id: 259564:MBUR_RS10295
uniprot id: Q12UK8
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

259564:MBUR RS10710
gene id: 259564:MBUR_RS10710
uniprot id: Q12UD0
names: Similarity
messages: Belongs to the DtxR/MntR family.

259564:MBUR RS12375
gene id: 259564:MBUR_RS12375
uniprot id: Q12TJ2
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

259564:MBUR RS05005
gene id: 259564:MBUR_RS05005
uniprot id: Q12XB3
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

259564:MBUR RS05880
gene id: 259564:MBUR_RS05880
uniprot id: Q12WV7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS07415
gene id: 259564:MBUR_RS07415
uniprot id: Q12W28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

259564:MBUR RS03140
gene id: 259564:MBUR_RS03140
uniprot id: Q12Y87
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS05415
gene id: 259564:MBUR_RS05415
uniprot id: Q12X41
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS04605
gene id: 259564:MBUR_RS04605
uniprot id: Q12XI3
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS10625
gene id: 259564:MBUR_RS10625
uniprot id: Q12UE4
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS11025
gene id: 259564:MBUR_RS11025
uniprot id: Q12U71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

259564:MBUR RS06775
gene id: 259564:MBUR_RS06775
uniprot id: Q12WD9
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

259564:MBUR RS08750
gene id: 259564:MBUR_RS08750
uniprot id: Q12VD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

259564:MBUR RS02475
gene id: 259564:MBUR_RS02475
uniprot id: Q12YK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

259564:MBUR RS06700
gene id: 259564:MBUR_RS06700
uniprot id: Q12WF4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

259564:MBUR RS05245
gene id: 259564:MBUR_RS05245
uniprot id: Q12X70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

259564:MBUR RS07090
gene id: 259564:MBUR_RS07090
uniprot id: Q12W85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

259564:MBUR RS09845
gene id: 259564:MBUR_RS09845
uniprot id: Q12UU1
names: Similarity
messages: Belongs to the UPF0288 family.

259564:MBUR RS06835
gene id: 259564:MBUR_RS06835
uniprot id: Q12WC9
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

259564:MBUR RS04830
gene id: 259564:MBUR_RS04830
uniprot id: Q12XE1
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

259564:MBUR RS02325
gene id: 259564:MBUR_RS02325
uniprot id: Q12YN4
names: Similarity
messages: Belongs to the threonine synthase family.

259564:MBUR RS04425
gene id: 259564:MBUR_RS04425
uniprot id: Q12XL5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

259564:MBUR RS03005
gene id: 259564:MBUR_RS03005
uniprot id: Q12YB2
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

259564:MBUR RS00015
gene id: 259564:MBUR_RS00015
uniprot id: Q12ZV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

259564:MBUR RS02465
gene id: 259564:MBUR_RS02465
uniprot id: Q12YK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

259564:MBUR RS07545
gene id: 259564:MBUR_RS07545
uniprot id: Q12W05
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

259564:MBUR RS12590
gene id: 259564:MBUR_RS12590
uniprot id: Q12TF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).

259564:MBUR RS11470
gene id: 259564:MBUR_RS11470
uniprot id: Q12TZ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

259564:MBUR RS10170
gene id: 259564:MBUR_RS10170
uniprot id: Q12UN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

259564:MBUR RS09110
gene id: 259564:MBUR_RS09110
uniprot id: Q12V70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

259564:MBUR RS00425
gene id: 259564:MBUR_RS00425
uniprot id: Q12ZM3
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS01320
gene id: 259564:MBUR_RS01320
uniprot id: Q12Z60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

259564:MBUR RS05655
gene id: 259564:MBUR_RS05655
uniprot id: Q12X00
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

259564:MBUR RS09290
gene id: 259564:MBUR_RS09290
uniprot id: Q12V43
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS00525
gene id: 259564:MBUR_RS00525
uniprot id: Q12ZK6
names: Similarity
messages: Belongs to the glutaredoxin family.

259564:MBUR RS09520
gene id: 259564:MBUR_RS09520
uniprot id: Q12V04
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS00340
gene id: 259564:MBUR_RS00340
uniprot id: Q12ZN9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

259564:MBUR RS02910
gene id: 259564:MBUR_RS02910
uniprot id: Q12YC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

259564:MBUR RS03035
gene id: 259564:MBUR_RS03035
uniprot id: Q12YA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

259564:MBUR RS08335
gene id: 259564:MBUR_RS08335
uniprot id: Q12VK5
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS06800
gene id: 259564:MBUR_RS06800
uniprot id: Q12WD5
names: Similarity
messages: Belongs to the acylphosphatase family.

259564:MBUR RS10290
gene id: 259564:MBUR_RS10290
uniprot id: Q12UK9
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

259564:MBUR RS07825
gene id: 259564:MBUR_RS07825
uniprot id: Q12VV1
names: Similarity
messages: Belongs to the MtrH family.

259564:MBUR RS09755
gene id: 259564:MBUR_RS09755
uniprot id: Q12UV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

259564:MBUR RS07115
gene id: 259564:MBUR_RS07115
uniprot id: Q12W81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

259564:MBUR RS11315
gene id: 259564:MBUR_RS11315
uniprot id: Q12U19
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

259564:MBUR RS10260
gene id: 259564:MBUR_RS10260
uniprot id: Q12UL5
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

259564:MBUR RS08695
gene id: 259564:MBUR_RS08695
uniprot id: Q12VE5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

259564:MBUR RS09135
gene id: 259564:MBUR_RS09135
uniprot id: Q12V65
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

259564:MBUR RS00685
gene id: 259564:MBUR_RS00685
uniprot id: Q12ZH7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS10265
gene id: 259564:MBUR_RS10265
uniprot id: Q12UL4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

259564:MBUR RS14060
gene id: 259564:MBUR_RS14060
uniprot id: Q12Z47
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

259564:MBUR RS11640
gene id: 259564:MBUR_RS11640
uniprot id: Q12TW0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

259564:MBUR RS03630
gene id: 259564:MBUR_RS03630
uniprot id: Q12Y02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

259564:MBUR RS06625
gene id: 259564:MBUR_RS06625
uniprot id: Q12WG7
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS10045
gene id: 259564:MBUR_RS10045
uniprot id: Q12UQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

259564:MBUR RS06725
gene id: 259564:MBUR_RS06725
uniprot id: Q12WF0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

259564:MBUR RS03280
gene id: 259564:MBUR_RS03280
uniprot id: Q12Y59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

259564:MBUR RS10250
gene id: 259564:MBUR_RS10250
uniprot id: Q12UL7
names: Similarity
messages: Belongs to the aspartokinase family.

259564:MBUR RS12545
gene id: 259564:MBUR_RS12545
uniprot id: Q12TG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

259564:MBUR RS01125
gene id: 259564:MBUR_RS01125
uniprot id: Q12Z95
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

259564:MBUR RS01975
gene id: 259564:MBUR_RS01975
uniprot id: Q12YU3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS05280
gene id: 259564:MBUR_RS05280
uniprot id: Q12X66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

259564:MBUR RS01115
gene id: 259564:MBUR_RS01115
uniprot id: Q12Z97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

259564:MBUR RS07155
gene id: 259564:MBUR_RS07155
uniprot id: Q12W73
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

259564:MBUR RS09895
gene id: 259564:MBUR_RS09895
uniprot id: Q12UT1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

259564:MBUR RS05805
gene id: 259564:MBUR_RS05805
uniprot id: Q12WX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

259564:MBUR RS04420
gene id: 259564:MBUR_RS04420
uniprot id: Q12XL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

259564:MBUR RS12310
gene id: 259564:MBUR_RS12310
uniprot id: Q12TK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

259564:MBUR RS06565
gene id: 259564:MBUR_RS06565
uniprot id: Q12WH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

259564:MBUR RS10515
gene id: 259564:MBUR_RS10515
uniprot id: Q12UG7
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

259564:MBUR RS04730
gene id: 259564:MBUR_RS04730
uniprot id: Q12XG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

259564:MBUR RS01290
gene id: 259564:MBUR_RS01290
uniprot id: Q12Z66
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS03325
gene id: 259564:MBUR_RS03325
uniprot id: Q12Y50
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

259564:MBUR RS10245
gene id: 259564:MBUR_RS10245
uniprot id: Q12UL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

259564:MBUR RS05665
gene id: 259564:MBUR_RS05665
uniprot id: Q12WZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

259564:MBUR RS11750
gene id: 259564:MBUR_RS11750
uniprot id: Q12TU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

259564:MBUR RS06185
gene id: 259564:MBUR_RS06185
uniprot id: Q12WQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

259564:MBUR RS10800
gene id: 259564:MBUR_RS10800
uniprot id: Q12UB3
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

259564:MBUR RS04395
gene id: 259564:MBUR_RS04395
uniprot id: Q12XM1
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

259564:MBUR RS00065
gene id: 259564:MBUR_RS00065
uniprot id: Q12ZU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

259564:MBUR RS09685
gene id: 259564:MBUR_RS09685
uniprot id: Q12UX2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

259564:MBUR RS07330
gene id: 259564:MBUR_RS07330
uniprot id: Q12W43
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

259564:MBUR RS04435
gene id: 259564:MBUR_RS04435
uniprot id: Q12XL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex.

259564:MBUR RS11005
gene id: 259564:MBUR_RS11005
uniprot id: Q12U75
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

259564:MBUR RS06380
gene id: 259564:MBUR_RS06380
uniprot id: Q12WL2
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

259564:MBUR RS08960
gene id: 259564:MBUR_RS08960
uniprot id: Q12V97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

259564:MBUR RS00400
gene id: 259564:MBUR_RS00400
uniprot id: Q12ZM6
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS07005
gene id: 259564:MBUR_RS07005
uniprot id: Q12W98
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

259564:MBUR RS04725
gene id: 259564:MBUR_RS04725
uniprot id: Q12XG1
names: Similarity
messages: Belongs to the UPF0147 family.

259564:MBUR RS10055
gene id: 259564:MBUR_RS10055
uniprot id: Q12UQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

259564:MBUR RS07310
gene id: 259564:MBUR_RS07310
uniprot id: Q12W47
names: Similarity
messages: Belongs to the UPF0166 family.

259564:MBUR RS07050
gene id: 259564:MBUR_RS07050
uniprot id: Q12W91
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

259564:MBUR RS02420
gene id: 259564:MBUR_RS02420
uniprot id: Q12YL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

259564:MBUR RS09715
gene id: 259564:MBUR_RS09715
uniprot id: Q12UW6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS03645
gene id: 259564:MBUR_RS03645
uniprot id: Q12XZ9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

259564:MBUR RS06140
gene id: 259564:MBUR_RS06140
uniprot id: Q12WQ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

259564:MBUR RS08525
gene id: 259564:MBUR_RS08525
uniprot id: Q12VH1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

259564:MBUR RS06645
gene id: 259564:MBUR_RS06645
uniprot id: Q12WG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: FPO is composed of at least 12 different subunits. Subunits FpoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: FPO shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to quinones in the F(420)H(2):heterodisulfide oxidoreduction chain. The immediate electron acceptor for the enzyme in this species is believed to be methanophenazine. Couples the redox reaction to proton translocation (for every two electrons transferred, 0.9 hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
messages: Membrane

259564:MBUR RS04815
gene id: 259564:MBUR_RS04815
uniprot id: Q12XE4
names: Subcellular Location Annotation
messages: Cell membrane

259564:MBUR RS01070
gene id: 259564:MBUR_RS01070
uniprot id: Q12ZA6
names: Similarity
messages: Belongs to the UPF0285 family.

259564:MBUR RS05060
gene id: 259564:MBUR_RS05060
uniprot id: Q12XA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

259564:MBUR RS00140
gene id: 259564:MBUR_RS00140
uniprot id: Q12ZS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

259564:MBUR RS11940
gene id: 259564:MBUR_RS11940
uniprot id: Q12TR3
names: Subcellular Location Annotation
messages: Cell membrane

259564:MBUR RS10615
gene id: 259564:MBUR_RS10615
uniprot id: Q12UE6
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS06665
gene id: 259564:MBUR_RS06665
uniprot id: Q12WG1
names: Similarity
messages: Belongs to the complex I subunit 3 family.

259564:MBUR RS05190
gene id: 259564:MBUR_RS05190
uniprot id: Q12X81
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

259564:MBUR RS08140
gene id: 259564:MBUR_RS08140
uniprot id: Q12VP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

259564:MBUR RS07580
gene id: 259564:MBUR_RS07580
uniprot id: Q12VZ8
names: Similarity
messages: Belongs to the UPF0107 family.

259564:MBUR RS08520
gene id: 259564:MBUR_RS08520
uniprot id: Q12VH2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

259564:MBUR RS09655
gene id: 259564:MBUR_RS09655
uniprot id: Q12UX8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS06855
gene id: 259564:MBUR_RS06855
uniprot id: Q12WC7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

259564:MBUR RS06120
gene id: 259564:MBUR_RS06120
uniprot id: Q12WR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

259564:MBUR RS07725
gene id: 259564:MBUR_RS07725
uniprot id: Q12VX0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

259564:MBUR RS11335
gene id: 259564:MBUR_RS11335
uniprot id: Q12U15
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS04320
gene id: 259564:MBUR_RS04320
uniprot id: Q12XN3
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

259564:MBUR RS12565
gene id: 259564:MBUR_RS12565
uniprot id: Q12TF7
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

259564:MBUR RS08375
gene id: 259564:MBUR_RS08375
uniprot id: Q12VJ7
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.

259564:MBUR RS04255
gene id: 259564:MBUR_RS04255
uniprot id: Q12XP4
names: Similarity
messages: Belongs to the UPF0210 family.

259564:MBUR RS08845
gene id: 259564:MBUR_RS08845
uniprot id: Q12VB8
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS11655
gene id: 259564:MBUR_RS11655
uniprot id: Q12TV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

259564:MBUR RS11375
gene id: 259564:MBUR_RS11375
uniprot id: Q12U07
names: Caution
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

259564:MBUR RS08530
gene id: 259564:MBUR_RS08530
uniprot id: Q12VH0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

259564:MBUR RS07300
gene id: 259564:MBUR_RS07300
uniprot id: Q12W48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

259564:MBUR RS01875
gene id: 259564:MBUR_RS01875
uniprot id: Q12YW2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

259564:MBUR RS03995
gene id: 259564:MBUR_RS03995
uniprot id: Q12XU4
names: Similarity
messages: Belongs to the DtxR/MntR family.

259564:MBUR RS00120
gene id: 259564:MBUR_RS00120
uniprot id: Q12ZS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

259564:MBUR RS10430
gene id: 259564:MBUR_RS10430
uniprot id: Q12UI3
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

259564:MBUR RS09330
gene id: 259564:MBUR_RS09330
uniprot id: Q12V37
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS07400
gene id: 259564:MBUR_RS07400
uniprot id: Q12W31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

259564:MBUR RS00935
gene id: 259564:MBUR_RS00935
uniprot id: Q12ZD4
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS05055
gene id: 259564:MBUR_RS05055
uniprot id: Q12XA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

259564:MBUR RS06615
gene id: 259564:MBUR_RS06615
uniprot id: Q12WG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

259564:MBUR RS05675
gene id: 259564:MBUR_RS05675
uniprot id: Q12WZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

259564:MBUR RS08195
gene id: 259564:MBUR_RS08195
uniprot id: Q12VN3
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

259564:MBUR RS11345
gene id: 259564:MBUR_RS11345
uniprot id: Q12U13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

259564:MBUR RS09500
gene id: 259564:MBUR_RS09500
uniprot id: Q12V08
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS05225
gene id: 259564:MBUR_RS05225
uniprot id: Q12X74
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

259564:MBUR RS11305
gene id: 259564:MBUR_RS11305
uniprot id: Q12U21
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS00130
gene id: 259564:MBUR_RS00130
uniprot id: Q12ZS7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

259564:MBUR RS05080
gene id: 259564:MBUR_RS05080
uniprot id: Q12XA0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS00010
gene id: 259564:MBUR_RS00010
uniprot id: Q12ZV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

259564:MBUR RS12510
gene id: 259564:MBUR_RS12510
uniprot id: Q12TG7
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS04440
gene id: 259564:MBUR_RS04440
uniprot id: Q12XL2
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.

259564:MBUR RS06735
gene id: 259564:MBUR_RS06735
uniprot id: Q12WE8
names: Function
messages: Part of a potassium transport system.

259564:MBUR RS03780
gene id: 259564:MBUR_RS03780
uniprot id: Q12XX5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MPGP family.
messages: Divalent cations in the following order of efficiency: cobalt, magnesium, and, to a lesser extent, nickel ions.
messages: Involved in the biosynthesis of glucosylglycerate. Catalyzes the dephosphorylation of glucosyl-3-phosphoglycerate (GPG) and mannosyl-3-phosphoglycerate (MPG) to glucosylglycerate (GG) and mannosylglycerate (MG), respectively.
messages: Monomer.

259564:MBUR RS05410
gene id: 259564:MBUR_RS05410
uniprot id: Q12X42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

259564:MBUR RS06020
gene id: 259564:MBUR_RS06020
uniprot id: O93632
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
messages: Cytoplasm

259564:MBUR RS12425
gene id: 259564:MBUR_RS12425
uniprot id: Q12TI2
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

259564:MBUR RS09295
gene id: 259564:MBUR_RS09295
uniprot id: Q12V42
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

259564:MBUR RS10915
gene id: 259564:MBUR_RS10915
uniprot id: Q12U91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

259564:MBUR RS03725
gene id: 259564:MBUR_RS03725
uniprot id: Q12XY4
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS06965
gene id: 259564:MBUR_RS06965
uniprot id: Q12WA6
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS07170
gene id: 259564:MBUR_RS07170
uniprot id: Q12W70
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

259564:MBUR RS06025
gene id: 259564:MBUR_RS06025
uniprot id: O93631
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

259564:MBUR RS03180
gene id: 259564:MBUR_RS03180
uniprot id: Q12Y79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

259564:MBUR RS03890
gene id: 259564:MBUR_RS03890
uniprot id: Q12XV8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS09815
gene id: 259564:MBUR_RS09815
uniprot id: Q12UU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

259564:MBUR RS09670
gene id: 259564:MBUR_RS09670
uniprot id: Q12UX5
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

259564:MBUR RS10565
gene id: 259564:MBUR_RS10565
uniprot id: Q12UF6
names: Similarity
messages: Belongs to the UPF0111 family.

259564:MBUR RS09775
gene id: 259564:MBUR_RS09775
uniprot id: Q12UV4
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

259564:MBUR RS03445
gene id: 259564:MBUR_RS03445
uniprot id: Q12Y32
names: Similarity
messages: Belongs to the UPF0228 family.

259564:MBUR RS06030
gene id: 259564:MBUR_RS06030
uniprot id: Q12WT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

259564:MBUR RS10550
gene id: 259564:MBUR_RS10550
uniprot id: Q12UF9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

259564:MBUR RS04820
gene id: 259564:MBUR_RS04820
uniprot id: Q12XE3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

259564:MBUR RS00025
gene id: 259564:MBUR_RS00025
uniprot id: Q12ZU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

259564:MBUR RS05220
gene id: 259564:MBUR_RS05220
uniprot id: Q12X75
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Reduced FMN (FMNH(2)).

259564:MBUR RS09125
gene id: 259564:MBUR_RS09125
uniprot id: Q12V67
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.

259564:MBUR RS04270
gene id: 259564:MBUR_RS04270
uniprot id: Q12XP1
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS11390
gene id: 259564:MBUR_RS11390
uniprot id: Q12U04
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

259564:MBUR RS05240
gene id: 259564:MBUR_RS05240
uniprot id: Q12X71
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS03595
gene id: 259564:MBUR_RS03595
uniprot id: Q12Y09
names: Similarity
messages: Belongs to the serpin family.

259564:MBUR RS00145
gene id: 259564:MBUR_RS00145
uniprot id: Q12ZS4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

259564:MBUR RS00125
gene id: 259564:MBUR_RS00125
uniprot id: Q12ZS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

259564:MBUR RS05075
gene id: 259564:MBUR_RS05075
uniprot id: Q12XA1
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS11915
gene id: 259564:MBUR_RS11915
uniprot id: Q12TR7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

259564:MBUR RS01890
gene id: 259564:MBUR_RS01890
uniprot id: Q12YV9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

259564:MBUR RS08065
gene id: 259564:MBUR_RS08065
uniprot id: Q12VQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

259564:MBUR RS00950
gene id: 259564:MBUR_RS00950
uniprot id: Q12ZD1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

259564:MBUR RS04105
gene id: 259564:MBUR_RS04105
uniprot id: Q12XS1
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

259564:MBUR RS12415
gene id: 259564:MBUR_RS12415
uniprot id: Q12TI4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

259564:MBUR RS01810
gene id: 259564:MBUR_RS01810
uniprot id: Q12YX5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

259564:MBUR RS11125
gene id: 259564:MBUR_RS11125
uniprot id: Q12U54
names: Similarity
messages: Belongs to the UPF0201 family.

259564:MBUR RS11255
gene id: 259564:MBUR_RS11255
uniprot id: Q12U32
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

259564:MBUR RS10345
gene id: 259564:MBUR_RS10345
uniprot id: Q12UJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

259564:MBUR RS04175
gene id: 259564:MBUR_RS04175
uniprot id: Q12XQ7
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

259564:MBUR RS06295
gene id: 259564:MBUR_RS06295
uniprot id: Q12WM9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS00510
gene id: 259564:MBUR_RS00510
uniprot id: Q12ZK9
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

259564:MBUR RS03345
gene id: 259564:MBUR_RS03345
uniprot id: Q12Y46
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

259564:MBUR RS04665
gene id: 259564:MBUR_RS04665
uniprot id: Q12XH1
names: Function
names: Similarity
messages: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

259564:MBUR RS07975
gene id: 259564:MBUR_RS07975
uniprot id: Q12VS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

259564:MBUR RS08500
gene id: 259564:MBUR_RS08500
uniprot id: Q12VH6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

259564:MBUR RS06065
gene id: 259564:MBUR_RS06065
uniprot id: Q12WS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

259564:MBUR RS00585
gene id: 259564:MBUR_RS00585
uniprot id: Q12ZJ4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

259564:MBUR RS06145
gene id: 259564:MBUR_RS06145
uniprot id: Q12WQ8
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

259564:MBUR RS11340
gene id: 259564:MBUR_RS11340
uniprot id: Q12U14
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

259564:MBUR RS12525
gene id: 259564:MBUR_RS12525
uniprot id: Q12TG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

259564:MBUR RS02170
gene id: 259564:MBUR_RS02170
uniprot id: Q12YR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

259564:MBUR RS05285
gene id: 259564:MBUR_RS05285
uniprot id: Q12X65
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

259564:MBUR RS04985
gene id: 259564:MBUR_RS04985
uniprot id: Q12XB7
names: Similarity
messages: Belongs to the UPF0212 family.

259564:MBUR RS08320
gene id: 259564:MBUR_RS08320
uniprot id: Q12VK8
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS12455
gene id: 259564:MBUR_RS12455
uniprot id: Q12TH6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

259564:MBUR RS11080
gene id: 259564:MBUR_RS11080
uniprot id: Q12U63
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

259564:MBUR RS07575
gene id: 259564:MBUR_RS07575
uniprot id: Q12VZ9
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS04495
gene id: 259564:MBUR_RS04495
uniprot id: Q12XK3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

259564:MBUR RS05595
gene id: 259564:MBUR_RS05595
uniprot id: Q12X08
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

259564:MBUR RS08625
gene id: 259564:MBUR_RS08625
uniprot id: Q12VF9
names: Similarity
messages: Belongs to the thymidylate kinase family.

259564:MBUR RS04995
gene id: 259564:MBUR_RS04995
uniprot id: Q12XB5
names: Similarity
messages: Belongs to the HerA family.

259564:MBUR RS02160
gene id: 259564:MBUR_RS02160
uniprot id: Q12YR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

259564:MBUR RS11570
gene id: 259564:MBUR_RS11570
uniprot id: Q12TX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

259564:MBUR RS12100
gene id: 259564:MBUR_RS12100
uniprot id: Q12TN6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

259564:MBUR RS08095
gene id: 259564:MBUR_RS08095
uniprot id: Q12VQ2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

259564:MBUR RS02280
gene id: 259564:MBUR_RS02280
uniprot id: Q12YP0
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS07190
gene id: 259564:MBUR_RS07190
uniprot id: Q12W65
names: Similarity
messages: Belongs to the eIF-2-alpha family.

259564:MBUR RS05550
gene id: 259564:MBUR_RS05550
uniprot id: Q12X17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

259564:MBUR RS11030
gene id: 259564:MBUR_RS11030
uniprot id: Q12U70
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS10520
gene id: 259564:MBUR_RS10520
uniprot id: Q12UG6
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

259564:MBUR RS03575
gene id: 259564:MBUR_RS03575
uniprot id: Q12Y13
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS00490
gene id: 259564:MBUR_RS00490
uniprot id: Q12ZL2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

259564:MBUR RS00710
gene id: 259564:MBUR_RS00710
uniprot id: Q12ZH2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

259564:MBUR RS11285
gene id: 259564:MBUR_RS11285
uniprot id: Q12U25
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

259564:MBUR RS05045
gene id: 259564:MBUR_RS05045
uniprot id: Q12XA7
names: Similarity
messages: Belongs to the TlyA family.

259564:MBUR RS06315
gene id: 259564:MBUR_RS06315
uniprot id: Q12WM5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

259564:MBUR RS08655
gene id: 259564:MBUR_RS08655
uniprot id: Q12VF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

259564:MBUR RS09115
gene id: 259564:MBUR_RS09115
uniprot id: Q12V69
names: Subcellular Location Annotation
messages: Cytoplasm

259564:MBUR RS05230
gene id: 259564:MBUR_RS05230
uniprot id: Q12X73
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

259564:MBUR RS12145
gene id: 259564:MBUR_RS12145
uniprot id: Q12TM7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

259564:MBUR RS09245
gene id: 259564:MBUR_RS09245
uniprot id: Q12V52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

259564:MBUR RS07020
gene id: 259564:MBUR_RS07020
uniprot id: Q12W95
names: Function
messages: Part of a potassium transport system.

259564:MBUR RS00300
gene id: 259564:MBUR_RS00300
uniprot id: Q12ZP6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

259564:MBUR RS07540
gene id: 259564:MBUR_RS07540
uniprot id: Q12W06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

259564:MBUR RS05255
gene id: 259564:MBUR_RS05255
uniprot id: Q12X69
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS06820
gene id: 259564:MBUR_RS06820
uniprot id: Q12WD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

259564:MBUR RS00090
gene id: 259564:MBUR_RS00090
uniprot id: Q12ZT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

259564:MBUR RS10275
gene id: 259564:MBUR_RS10275
uniprot id: Q12UL2
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

259564:MBUR RS12385
gene id: 259564:MBUR_RS12385
uniprot id: Q12TJ0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

259564:MBUR RS08405
gene id: 259564:MBUR_RS08405
uniprot id: Q12VJ2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

259564:MBUR RS12380
gene id: 259564:MBUR_RS12380
uniprot id: Q12TJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

259564:MBUR RS04660
gene id: 259564:MBUR_RS04660
uniprot id: Q12XH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

259564:MBUR RS06420
gene id: 259564:MBUR_RS06420
uniprot id: Q12WK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

259564:MBUR RS11595
gene id: 259564:MBUR_RS11595
uniprot id: Q12TW7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

259564:MBUR RS00890
gene id: 259564:MBUR_RS00890
uniprot id: Q12ZE1
names: Similarity
messages: Belongs to the TPP enzyme family.

259564:MBUR RS12285
gene id: 259564:MBUR_RS12285
uniprot id: Q12TK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

259564:MBUR RS09810
gene id: 259564:MBUR_RS09810
uniprot id: Q12UU8
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

259564:MBUR RS02345
gene id: 259564:MBUR_RS02345
uniprot id: Q12YM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

259564:MBUR RS05960
gene id: 259564:MBUR_RS05960
uniprot id: Q12WU3
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

259564:MBUR RS10150
gene id: 259564:MBUR_RS10150
uniprot id: Q12UN4
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

259564:MBUR RS00050
gene id: 259564:MBUR_RS00050
uniprot id: Q12ZU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

259564:MBUR RS08780
gene id: 259564:MBUR_RS08780
uniprot id: Q12VD0
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

259564:MBUR RS06395
gene id: 259564:MBUR_RS06395
uniprot id: Q12WK9
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

259564:MBUR RS06970
gene id: 259564:MBUR_RS06970
uniprot id: Q12WA5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

259564:MBUR RS12635
gene id: 259564:MBUR_RS12635
uniprot id: Q12TE3
names: Similarity
messages: Belongs to the MCM family.

259564:MBUR RS06540
gene id: 259564:MBUR_RS06540
uniprot id: Q12WI3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

259564:MBUR RS09320
gene id: 259564:MBUR_RS09320
uniprot id: Q12V39
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

259564:MBUR RS07270
gene id: 259564:MBUR_RS07270
uniprot id: Q12W53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

259564:MBUR RS11610
gene id: 259564:MBUR_RS11610
uniprot id: Q12TW5
names: Subcellular Location Annotation
messages: Membrane

259564:MBUR RS11510
gene id: 259564:MBUR_RS11510
uniprot id: Q12TY3
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.