2585118:FMF02 RS05930
gene id: 2585118:FMF02_RS05930
uniprot id: A0A4Y1WS06
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2585118:FMF02 RS04610
gene id: 2585118:FMF02_RS04610
uniprot id: A0A4Y1XUZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

2585118:FMF02 RS05130
gene id: 2585118:FMF02_RS05130
uniprot id: A0A4Y1WT85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

2585118:FMF02 RS07930
gene id: 2585118:FMF02_RS07930
uniprot id: A0A3D3YL66
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

2585118:FMF02 RS04685
gene id: 2585118:FMF02_RS04685
uniprot id: A0A4Y1WRT6
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

2585118:FMF02 RS03820
gene id: 2585118:FMF02_RS03820
uniprot id: A0A4Y1WTG4
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

2585118:FMF02 RS11405
gene id: 2585118:FMF02_RS11405
uniprot id: A0A4Y1WVB1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

2585118:FMF02 RS05115
gene id: 2585118:FMF02_RS05115
uniprot id: A0A4Y1XRA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

2585118:FMF02 RS03330
gene id: 2585118:FMF02_RS03330
uniprot id: A0A4Y1WQH6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

2585118:FMF02 RS05380
gene id: 2585118:FMF02_RS05380
uniprot id: A0A3D3YL41
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS03935
gene id: 2585118:FMF02_RS03935
uniprot id: A0A3D2BFA2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

2585118:FMF02 RS09915
gene id: 2585118:FMF02_RS09915
uniprot id: A0A3D2BBB2
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS11205
gene id: 2585118:FMF02_RS11205
uniprot id: A0A3D3YMC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

2585118:FMF02 RS12755
gene id: 2585118:FMF02_RS12755
uniprot id: A0A3D2BCK8
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

2585118:FMF02 RS04470
gene id: 2585118:FMF02_RS04470
uniprot id: A0A4Y1WR77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

2585118:FMF02 RS06610
gene id: 2585118:FMF02_RS06610
uniprot id: A0A4Y1XIX2
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS09150
gene id: 2585118:FMF02_RS09150
uniprot id: A0A4Y1WW56
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2585118:FMF02 RS05175
gene id: 2585118:FMF02_RS05175
uniprot id: A0A4Y1WRK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

2585118:FMF02 RS09035
gene id: 2585118:FMF02_RS09035
uniprot id: A0A3D2BIM1
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

2585118:FMF02 RS11375
gene id: 2585118:FMF02_RS11375
uniprot id: A0A3D3YME4
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS08280
gene id: 2585118:FMF02_RS08280
uniprot id: A0A3D2BD17
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

2585118:FMF02 RS01200
gene id: 2585118:FMF02_RS01200
uniprot id: A0A4Y1WPS2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

2585118:FMF02 RS08305
gene id: 2585118:FMF02_RS08305
uniprot id: A0A3D3YIU9
names: Similarity
messages: Belongs to the aspartokinase family.

2585118:FMF02 RS04045
gene id: 2585118:FMF02_RS04045
uniprot id: A0A4Y1WQW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

2585118:FMF02 RS02140
gene id: 2585118:FMF02_RS02140
uniprot id: A0A4Y1WQ96
names: Similarity
messages: Belongs to the SusD family.

2585118:FMF02 RS06390
gene id: 2585118:FMF02_RS06390
uniprot id: A0A3D3YJM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Membrane

2585118:FMF02 RS04280
gene id: 2585118:FMF02_RS04280
uniprot id: A0A3D3YLL1
names: Similarity
messages: Belongs to the Skp family.

2585118:FMF02 RS07730
gene id: 2585118:FMF02_RS07730
uniprot id: A0A4Y1WSZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

2585118:FMF02 RS06605
gene id: 2585118:FMF02_RS06605
uniprot id: A0A3D3YNA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

2585118:FMF02 RS05720
gene id: 2585118:FMF02_RS05720
uniprot id: A0A4Y1WRW4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

2585118:FMF02 RS05675
gene id: 2585118:FMF02_RS05675
uniprot id: A0A4Y1WRV6
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

2585118:FMF02 RS06520
gene id: 2585118:FMF02_RS06520
uniprot id: A0A4Y1XU11
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

2585118:FMF02 RS01270
gene id: 2585118:FMF02_RS01270
uniprot id: A0A3D2BB76
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

2585118:FMF02 RS04875
gene id: 2585118:FMF02_RS04875
uniprot id: A0A4Y1WU11
names: Similarity
messages: Belongs to the type IA topoisomerase family.

2585118:FMF02 RS05740
gene id: 2585118:FMF02_RS05740
uniprot id: A0A3D3YQ37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

2585118:FMF02 RS00950
gene id: 2585118:FMF02_RS00950
uniprot id: A0A3D3YNI3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

2585118:FMF02 RS05570
gene id: 2585118:FMF02_RS05570
uniprot id: A0A3D2BDM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

2585118:FMF02 RS08505
gene id: 2585118:FMF02_RS08505
uniprot id: A0A4Y1WW33
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

2585118:FMF02 RS03515
gene id: 2585118:FMF02_RS03515
uniprot id: A0A4Y1XUA1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

2585118:FMF02 RS13500
gene id: 2585118:FMF02_RS13500
uniprot id: A0A3D3YNI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

2585118:FMF02 RS07795
gene id: 2585118:FMF02_RS07795
uniprot id: A0A4Y1WUU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

2585118:FMF02 RS03525
gene id: 2585118:FMF02_RS03525
uniprot id: A0A3D3YSC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

2585118:FMF02 RS07135
gene id: 2585118:FMF02_RS07135
uniprot id: A0A3D3YJ22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

2585118:FMF02 RS08315
gene id: 2585118:FMF02_RS08315
uniprot id: A0A4Y1XM15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

2585118:FMF02 RS09250
gene id: 2585118:FMF02_RS09250
uniprot id: A0A3D2BFH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

2585118:FMF02 RS02565
gene id: 2585118:FMF02_RS02565
uniprot id: A0A4Y1XRC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

2585118:FMF02 RS01185
gene id: 2585118:FMF02_RS01185
uniprot id: A0A3D3YLS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

2585118:FMF02 RS03940
gene id: 2585118:FMF02_RS03940
uniprot id: A0A3D3YLF0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

2585118:FMF02 RS08550
gene id: 2585118:FMF02_RS08550
uniprot id: A0A4Y1WW39
names: Similarity
messages: Belongs to the SusD family.

2585118:FMF02 RS11745
gene id: 2585118:FMF02_RS11745
uniprot id: A0A4Y1WV79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

2585118:FMF02 RS07405
gene id: 2585118:FMF02_RS07405
uniprot id: A0A3D3YN95
names: Similarity
messages: Belongs to the SusD family.

2585118:FMF02 RS08705
gene id: 2585118:FMF02_RS08705
uniprot id: A0A3D3YPT4
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

2585118:FMF02 RS06705
gene id: 2585118:FMF02_RS06705
uniprot id: A0A4Y1WSE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

2585118:FMF02 RS13530
gene id: 2585118:FMF02_RS13530
uniprot id: A0A3D3YRN4
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS05225
gene id: 2585118:FMF02_RS05225
uniprot id: A0A4Y1WRL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

2585118:FMF02 RS02865
gene id: 2585118:FMF02_RS02865
uniprot id: A0A3D2BDF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

2585118:FMF02 RS02385
gene id: 2585118:FMF02_RS02385
uniprot id: A0A3D3YQS4
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

2585118:FMF02 RS13175
gene id: 2585118:FMF02_RS13175
uniprot id: A0A4Y1XN05
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

2585118:FMF02 RS00015
gene id: 2585118:FMF02_RS00015
uniprot id: A0A3D2BEX2
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS10055
gene id: 2585118:FMF02_RS10055
uniprot id: A0A4Y1WW49
names: Similarity
messages: Belongs to the DEAD box helicase family.

2585118:FMF02 RS13450
gene id: 2585118:FMF02_RS13450
uniprot id: A0A3D3YM20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

2585118:FMF02 RS04055
gene id: 2585118:FMF02_RS04055
uniprot id: A0A4Y1WR00
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

2585118:FMF02 RS06125
gene id: 2585118:FMF02_RS06125
uniprot id: A0A4Y1WUU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

2585118:FMF02 RS01135
gene id: 2585118:FMF02_RS01135
uniprot id: A0A4Y1WRN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family.
messages: Cytoplasm

2585118:FMF02 RS06860
gene id: 2585118:FMF02_RS06860
uniprot id: A0A4Y1WSG7
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

2585118:FMF02 RS07620
gene id: 2585118:FMF02_RS07620
uniprot id: A0A4Y1WVM3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2585118:FMF02 RS13205
gene id: 2585118:FMF02_RS13205
uniprot id: A0A4Y1WYD4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

2585118:FMF02 RS04160
gene id: 2585118:FMF02_RS04160
uniprot id: A0A3D2BEY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

2585118:FMF02 RS05105
gene id: 2585118:FMF02_RS05105
uniprot id: A0A4Y1WTU7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

2585118:FMF02 RS04585
gene id: 2585118:FMF02_RS04585
uniprot id: A0A4Y1WTW6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

2585118:FMF02 RS03855
gene id: 2585118:FMF02_RS03855
uniprot id: A0A3D3YMC0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

2585118:FMF02 RS05665
gene id: 2585118:FMF02_RS05665
uniprot id: A0A3D3YPH5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

2585118:FMF02 RS09305
gene id: 2585118:FMF02_RS09305
uniprot id: A0A4Y1WUF2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2585118:FMF02 RS03850
gene id: 2585118:FMF02_RS03850
uniprot id: A0A3D3YN50
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

2585118:FMF02 RS11990
gene id: 2585118:FMF02_RS11990
uniprot id: A0A4Y1XP76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

2585118:FMF02 RS10920
gene id: 2585118:FMF02_RS10920
uniprot id: A0A4Y1WUS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

2585118:FMF02 RS09670
gene id: 2585118:FMF02_RS09670
uniprot id: A0A3D3YKA0
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS07305
gene id: 2585118:FMF02_RS07305
uniprot id: A0A4Y1WUJ9
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS05075
gene id: 2585118:FMF02_RS05075
uniprot id: A0A3D3YR00
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

2585118:FMF02 RS06400
gene id: 2585118:FMF02_RS06400
uniprot id: A0A3D3YJ24
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

2585118:FMF02 RS12605
gene id: 2585118:FMF02_RS12605
uniprot id: A0A4Y1WY54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

2585118:FMF02 RS05070
gene id: 2585118:FMF02_RS05070
uniprot id: A0A3D3YR76
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

2585118:FMF02 RS10905
gene id: 2585118:FMF02_RS10905
uniprot id: A0A3D3YNZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

2585118:FMF02 RS04860
gene id: 2585118:FMF02_RS04860
uniprot id: A0A4Y1WRE5
names: Function
names: Similarity
messages: Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

2585118:FMF02 RS09025
gene id: 2585118:FMF02_RS09025
uniprot id: A0A3D3YM47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

2585118:FMF02 RS01345
gene id: 2585118:FMF02_RS01345
uniprot id: A0A4Y1WPA8
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

2585118:FMF02 RS05540
gene id: 2585118:FMF02_RS05540
uniprot id: A0A4Y1WTG3
names: Similarity
messages: Belongs to the DprA/Smf family.

2585118:FMF02 RS10075
gene id: 2585118:FMF02_RS10075
uniprot id: A0A3D3YKS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

2585118:FMF02 RS11180
gene id: 2585118:FMF02_RS11180
uniprot id: A0A4Y1WXQ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

2585118:FMF02 RS05135
gene id: 2585118:FMF02_RS05135
uniprot id: A0A4Y1XS27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

2585118:FMF02 RS07670
gene id: 2585118:FMF02_RS07670
uniprot id: A0A3D2BDC1
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

2585118:FMF02 RS11870
gene id: 2585118:FMF02_RS11870
uniprot id: A0A3D3YLM5
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS13410
gene id: 2585118:FMF02_RS13410
uniprot id: A0A4Y1WYH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

2585118:FMF02 RS00965
gene id: 2585118:FMF02_RS00965
uniprot id: A0A3D3YLC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

2585118:FMF02 RS04480
gene id: 2585118:FMF02_RS04480
uniprot id: A0A4Y1WS80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

2585118:FMF02 RS11970
gene id: 2585118:FMF02_RS11970
uniprot id: A0A4Y1WXQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

2585118:FMF02 RS10040
gene id: 2585118:FMF02_RS10040
uniprot id: A0A4Y1WUC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

2585118:FMF02 RS00865
gene id: 2585118:FMF02_RS00865
uniprot id: A0A3D2BF13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

2585118:FMF02 RS06710
gene id: 2585118:FMF02_RS06710
uniprot id: A0A3D2BGV5
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

2585118:FMF02 RS02855
gene id: 2585118:FMF02_RS02855
uniprot id: A0A3D2BDF5
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

2585118:FMF02 RS11230
gene id: 2585118:FMF02_RS11230
uniprot id: A0A4Y1WXQ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrF family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

2585118:FMF02 RS12730
gene id: 2585118:FMF02_RS12730
uniprot id: A0A3D3YKW3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

2585118:FMF02 RS11905
gene id: 2585118:FMF02_RS11905
uniprot id: A0A3D3YHH6
names: Function
messages: Might have a role analogous to that of eukaryotic histone proteins.

2585118:FMF02 RS07665
gene id: 2585118:FMF02_RS07665
uniprot id: A0A3D3YP25
names: Similarity
messages: Belongs to the SAICAR synthetase family.

2585118:FMF02 RS06775
gene id: 2585118:FMF02_RS06775
uniprot id: A0A3D3YQ52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

2585118:FMF02 RS05140
gene id: 2585118:FMF02_RS05140
uniprot id: A0A4Y1WU61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

2585118:FMF02 RS08970
gene id: 2585118:FMF02_RS08970
uniprot id: A0A4Y1WTP4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2585118:FMF02 RS00855
gene id: 2585118:FMF02_RS00855
uniprot id: A0A4Y1WP06
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

2585118:FMF02 RS11940
gene id: 2585118:FMF02_RS11940
uniprot id: A0A4Y1WVB7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2585118:FMF02 RS06180
gene id: 2585118:FMF02_RS06180
uniprot id: A0A4Y1XRS9
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS07250
gene id: 2585118:FMF02_RS07250
uniprot id: A0A3D3YKM7
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

2585118:FMF02 RS09090
gene id: 2585118:FMF02_RS09090
uniprot id: A0A3D3YL06
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2585118:FMF02 RS06985
gene id: 2585118:FMF02_RS06985
uniprot id: A0A4Y1WVB0
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS01225
gene id: 2585118:FMF02_RS01225
uniprot id: A0A4Y1XNS8
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

2585118:FMF02 RS05255
gene id: 2585118:FMF02_RS05255
uniprot id: A0A4Y1WUD0
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.
messages: Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man-Glc) to mannose 1-phosphate (Man1P) and glucose.

2585118:FMF02 RS02340
gene id: 2585118:FMF02_RS02340
uniprot id: A0A3D3YQJ9
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

2585118:FMF02 RS07195
gene id: 2585118:FMF02_RS07195
uniprot id: A0A4Y1XL45
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

2585118:FMF02 RS03900
gene id: 2585118:FMF02_RS03900
uniprot id: A0A4Y1WQT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

2585118:FMF02 RS01430
gene id: 2585118:FMF02_RS01430
uniprot id: A0A3D3YKY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

2585118:FMF02 RS08960
gene id: 2585118:FMF02_RS08960
uniprot id: A0A3D3YP35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxC family.
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

2585118:FMF02 RS01435
gene id: 2585118:FMF02_RS01435
uniprot id: A0A3D3YJR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

2585118:FMF02 RS03540
gene id: 2585118:FMF02_RS03540
uniprot id: A0A3D2BFF1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

2585118:FMF02 RS08495
gene id: 2585118:FMF02_RS08495
uniprot id: A0A4Y1WVU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

2585118:FMF02 RS08055
gene id: 2585118:FMF02_RS08055
uniprot id: A0A4Y1XK18
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

2585118:FMF02 RS10050
gene id: 2585118:FMF02_RS10050
uniprot id: A0A4Y1WU86
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

2585118:FMF02 RS10045
gene id: 2585118:FMF02_RS10045
uniprot id: A0A3D3YNJ5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2585118:FMF02 RS07085
gene id: 2585118:FMF02_RS07085
uniprot id: A0A4Y1WVC5
names: Similarity
messages: Belongs to the SusD family.

2585118:FMF02 RS05205
gene id: 2585118:FMF02_RS05205
uniprot id: A0A4Y1WTW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

2585118:FMF02 RS07145
gene id: 2585118:FMF02_RS07145
uniprot id: A0A3D2BBI1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

2585118:FMF02 RS00785
gene id: 2585118:FMF02_RS00785
uniprot id: A0A4Y1WPX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

2585118:FMF02 RS05090
gene id: 2585118:FMF02_RS05090
uniprot id: A0A3D3YQ02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

2585118:FMF02 RS03435
gene id: 2585118:FMF02_RS03435
uniprot id: A0A3D3YPN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

2585118:FMF02 RS05190
gene id: 2585118:FMF02_RS05190
uniprot id: A0A4Y1XVP4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

2585118:FMF02 RS08715
gene id: 2585118:FMF02_RS08715
uniprot id: A0A4Y1XKS6
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

2585118:FMF02 RS08285
gene id: 2585118:FMF02_RS08285
uniprot id: A0A4Y1XKQ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

2585118:FMF02 RS09700
gene id: 2585118:FMF02_RS09700
uniprot id: A0A3D3YM28
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

2585118:FMF02 RS02300
gene id: 2585118:FMF02_RS02300
uniprot id: A0A4Y1WSP1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

2585118:FMF02 RS08145
gene id: 2585118:FMF02_RS08145
uniprot id: A0A3D2BG52
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

2585118:FMF02 RS00820
gene id: 2585118:FMF02_RS00820
uniprot id: A0A4Y1WQP4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

2585118:FMF02 RS13130
gene id: 2585118:FMF02_RS13130
uniprot id: A0A4Y1WXQ7
names: Subcellular Location Annotation
messages: Cytoplasm

2585118:FMF02 RS05340
gene id: 2585118:FMF02_RS05340
uniprot id: A0A4Y1WSQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

2585118:FMF02 RS01320
gene id: 2585118:FMF02_RS01320
uniprot id: A0A4Y1XQF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

2585118:FMF02 RS00810
gene id: 2585118:FMF02_RS00810
uniprot id: A0A4Y1WPJ5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2585118:FMF02 RS04010
gene id: 2585118:FMF02_RS04010
uniprot id: A0A3D2BF70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

2585118:FMF02 RS11750
gene id: 2585118:FMF02_RS11750
uniprot id: A0A4Y1XMF6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

2585118:FMF02 RS11935
gene id: 2585118:FMF02_RS11935
uniprot id: A0A4Y1WW26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

2585118:FMF02 RS08080
gene id: 2585118:FMF02_RS08080
uniprot id: A0A4Y1WV03
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

2585118:FMF02 RS10850
gene id: 2585118:FMF02_RS10850
uniprot id: A0A3D3YLV3
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS12245
gene id: 2585118:FMF02_RS12245
uniprot id: A0A4Y1WX96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

2585118:FMF02 RS10210
gene id: 2585118:FMF02_RS10210
uniprot id: A0A4Y1WVF9
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

2585118:FMF02 RS01165
gene id: 2585118:FMF02_RS01165
uniprot id: A0A3D3YM62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

2585118:FMF02 RS06900
gene id: 2585118:FMF02_RS06900
uniprot id: A0A3D3YR85
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

2585118:FMF02 RS03920
gene id: 2585118:FMF02_RS03920
uniprot id: A0A4Y1WRX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

2585118:FMF02 RS05765
gene id: 2585118:FMF02_RS05765
uniprot id: A0A4Y1WUB7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

2585118:FMF02 RS01515
gene id: 2585118:FMF02_RS01515
uniprot id: A0A4Y1WQM6
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

2585118:FMF02 RS01405
gene id: 2585118:FMF02_RS01405
uniprot id: A0A3D3YKI1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

2585118:FMF02 RS07230
gene id: 2585118:FMF02_RS07230
uniprot id: A0A4Y1XL61
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

2585118:FMF02 RS01065
gene id: 2585118:FMF02_RS01065
uniprot id: A0A3D2BEG4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

2585118:FMF02 RS03860
gene id: 2585118:FMF02_RS03860
uniprot id: A0A4Y1WQV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

2585118:FMF02 RS07935
gene id: 2585118:FMF02_RS07935
uniprot id: A0A3D2BBL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

2585118:FMF02 RS09695
gene id: 2585118:FMF02_RS09695
uniprot id: A0A3D2BBA2
names: Similarity
messages: Belongs to the Skp family.

2585118:FMF02 RS13135
gene id: 2585118:FMF02_RS13135
uniprot id: A0A4Y1XN66
names: Function
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.

2585118:FMF02 RS06425
gene id: 2585118:FMF02_RS06425
uniprot id: A0A4Y1WUL8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

2585118:FMF02 RS10780
gene id: 2585118:FMF02_RS10780
uniprot id: A0A4Y1WV63
names: Similarity
messages: Belongs to the NusB family.

2585118:FMF02 RS05155
gene id: 2585118:FMF02_RS05155
uniprot id: A0A4Y1WTV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

2585118:FMF02 RS09245
gene id: 2585118:FMF02_RS09245
uniprot id: A0A3D3YN03
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2585118:FMF02 RS08660
gene id: 2585118:FMF02_RS08660
uniprot id: A0A4Y1WTI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

2585118:FMF02 RS13190
gene id: 2585118:FMF02_RS13190
uniprot id: A0A4Y1XPR5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

2585118:FMF02 RS08710
gene id: 2585118:FMF02_RS08710
uniprot id: A0A4Y1XMA6
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

2585118:FMF02 RS11550
gene id: 2585118:FMF02_RS11550
uniprot id: A0A4Y1WXV5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2585118:FMF02 RS13145
gene id: 2585118:FMF02_RS13145
uniprot id: A0A3D3YM96
names: Similarity
messages: Belongs to the DEAD box helicase family.

2585118:FMF02 RS10595
gene id: 2585118:FMF02_RS10595
uniprot id: A0A4Y1XNE7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

2585118:FMF02 RS10890
gene id: 2585118:FMF02_RS10890
uniprot id: A0A4Y1WV86
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

2585118:FMF02 RS00900
gene id: 2585118:FMF02_RS00900
uniprot id: A0A3D3YPH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

2585118:FMF02 RS09365
gene id: 2585118:FMF02_RS09365
uniprot id: A0A4Y1WW75
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

2585118:FMF02 RS05100
gene id: 2585118:FMF02_RS05100
uniprot id: A0A3D3YPG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

2585118:FMF02 RS04375
gene id: 2585118:FMF02_RS04375
uniprot id: A0A3D2BCW1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2585118:FMF02 RS10225
gene id: 2585118:FMF02_RS10225
uniprot id: A0A3D3YN24
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

2585118:FMF02 RS08795
gene id: 2585118:FMF02_RS08795
uniprot id: A0A4Y1XM14
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

2585118:FMF02 RS05215
gene id: 2585118:FMF02_RS05215
uniprot id: A0A4Y1XRC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

2585118:FMF02 RS12385
gene id: 2585118:FMF02_RS12385
uniprot id: A0A3D3YNI4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

2585118:FMF02 RS02840
gene id: 2585118:FMF02_RS02840
uniprot id: A0A4Y1WQ75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

2585118:FMF02 RS10430
gene id: 2585118:FMF02_RS10430
uniprot id: A0A3D3YM52
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

2585118:FMF02 RS09795
gene id: 2585118:FMF02_RS09795
uniprot id: A0A3D2BE61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

2585118:FMF02 RS11255
gene id: 2585118:FMF02_RS11255
uniprot id: A0A3D3YP18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

2585118:FMF02 RS12410
gene id: 2585118:FMF02_RS12410
uniprot id: A0A3D3YLM0
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

2585118:FMF02 RS05615
gene id: 2585118:FMF02_RS05615
uniprot id: A0A3D3YMD1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2585118:FMF02 RS07170
gene id: 2585118:FMF02_RS07170
uniprot id: A0A4Y1WTS3
names: Similarity
messages: Belongs to the SusD family.

2585118:FMF02 RS03700
gene id: 2585118:FMF02_RS03700
uniprot id: A0A4Y1XRM7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2585118:FMF02 RS04015
gene id: 2585118:FMF02_RS04015
uniprot id: A0A3D3YJA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

2585118:FMF02 RS01205
gene id: 2585118:FMF02_RS01205
uniprot id: A0A4Y1WP87
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

2585118:FMF02 RS02590
gene id: 2585118:FMF02_RS02590
uniprot id: A0A4Y1XPF5
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2585118:FMF02 RS05690
gene id: 2585118:FMF02_RS05690
uniprot id: A0A4Y1WTJ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

2585118:FMF02 RS08630
gene id: 2585118:FMF02_RS08630
uniprot id: A0A3D3YRH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

2585118:FMF02 RS02800
gene id: 2585118:FMF02_RS02800
uniprot id: A0A3D3YMZ7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

2585118:FMF02 RS01070
gene id: 2585118:FMF02_RS01070
uniprot id: A0A3D3YNU9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2585118:FMF02 RS06500
gene id: 2585118:FMF02_RS06500
uniprot id: A0A3D2BEG7
names: Similarity
messages: Belongs to the XseB family.

2585118:FMF02 RS08985
gene id: 2585118:FMF02_RS08985
uniprot id: A0A4Y1WTM9
names: Similarity
messages: Belongs to the SusD family.

2585118:FMF02 RS12315
gene id: 2585118:FMF02_RS12315
uniprot id: A0A3D3YLN3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

2585118:FMF02 RS04260
gene id: 2585118:FMF02_RS04260
uniprot id: A0A3D3YN00
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2585118:FMF02 RS06620
gene id: 2585118:FMF02_RS06620
uniprot id: A0A4Y1WUR9
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

2585118:FMF02 RS03530
gene id: 2585118:FMF02_RS03530
uniprot id: A0A3D2BFB9
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

2585118:FMF02 RS05145
gene id: 2585118:FMF02_RS05145
uniprot id: A0A4Y1XRN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

2585118:FMF02 RS05200
gene id: 2585118:FMF02_RS05200
uniprot id: A0A4Y1WUC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

2585118:FMF02 RS02890
gene id: 2585118:FMF02_RS02890
uniprot id: A0A4Y1WQ84
names: Similarity
messages: Belongs to the Nudix hydrolase family.

2585118:FMF02 RS05180
gene id: 2585118:FMF02_RS05180
uniprot id: A0A4Y1XT95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

2585118:FMF02 RS07640
gene id: 2585118:FMF02_RS07640
uniprot id: A0A4Y1WTM8
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

2585118:FMF02 RS10650
gene id: 2585118:FMF02_RS10650
uniprot id: A0A4Y1WUV3
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS01950
gene id: 2585118:FMF02_RS01950
uniprot id: A0A4Y1WPN3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

2585118:FMF02 RS07710
gene id: 2585118:FMF02_RS07710
uniprot id: A0A4Y1XJH9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.

2585118:FMF02 RS05910
gene id: 2585118:FMF02_RS05910
uniprot id: A0A4Y1WSP3
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

2585118:FMF02 RS06810
gene id: 2585118:FMF02_RS06810
uniprot id: A0A4Y1WSG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

2585118:FMF02 RS08925
gene id: 2585118:FMF02_RS08925
uniprot id: A0A4Y1WTN4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

2585118:FMF02 RS02290
gene id: 2585118:FMF02_RS02290
uniprot id: A0A4Y1WRG6
names: Similarity
messages: Belongs to the UPF0047 family.

2585118:FMF02 RS04565
gene id: 2585118:FMF02_RS04565
uniprot id: A0A3D3YJ85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

2585118:FMF02 RS00115
gene id: 2585118:FMF02_RS00115
uniprot id: A0A3D2BAT5
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

2585118:FMF02 RS05160
gene id: 2585118:FMF02_RS05160
uniprot id: A0A4Y1XRC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

2585118:FMF02 RS05085
gene id: 2585118:FMF02_RS05085
uniprot id: A0A4Y1WSI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

2585118:FMF02 RS07675
gene id: 2585118:FMF02_RS07675
uniprot id: A0A4Y1WSZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

2585118:FMF02 RS01300
gene id: 2585118:FMF02_RS01300
uniprot id: A0A4Y1WPU3
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

2585118:FMF02 RS13395
gene id: 2585118:FMF02_RS13395
uniprot id: A0A3D3YQ57
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

2585118:FMF02 RS11330
gene id: 2585118:FMF02_RS11330
uniprot id: A0A4Y1WVH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

2585118:FMF02 RS03535
gene id: 2585118:FMF02_RS03535
uniprot id: A0A3D2BFK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

2585118:FMF02 RS12765
gene id: 2585118:FMF02_RS12765
uniprot id: A0A3D2BCB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

2585118:FMF02 RS02405
gene id: 2585118:FMF02_RS02405
uniprot id: A0A3D3YNM7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

2585118:FMF02 RS05980
gene id: 2585118:FMF02_RS05980
uniprot id: A0A3D3YQ17
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

2585118:FMF02 RS05195
gene id: 2585118:FMF02_RS05195
uniprot id: A0A4Y1WSA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

2585118:FMF02 RS09675
gene id: 2585118:FMF02_RS09675
uniprot id: A0A4Y1WUK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
messages: Cell membrane
messages: Mediates zinc uptake. May also transport other divalent cations.
messages: Membrane

2585118:FMF02 RS06690
gene id: 2585118:FMF02_RS06690
uniprot id: A0A4Y1WSG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

2585118:FMF02 RS00940
gene id: 2585118:FMF02_RS00940
uniprot id: A0A4Y1WS36
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

2585118:FMF02 RS00050
gene id: 2585118:FMF02_RS00050
uniprot id: A0A4Y1WPT7
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS06975
gene id: 2585118:FMF02_RS06975
uniprot id: A0A4Y1WUX8
names: Caution
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2585118:FMF02 RS08240
gene id: 2585118:FMF02_RS08240
uniprot id: A0A4Y1WTT6
names: Similarity
messages: Belongs to the SusD family.

2585118:FMF02 RS09230
gene id: 2585118:FMF02_RS09230
uniprot id: A0A4Y1XPK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

2585118:FMF02 RS08200
gene id: 2585118:FMF02_RS08200
uniprot id: A0A4Y1XP20
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS05010
gene id: 2585118:FMF02_RS05010
uniprot id: A0A3D3YMZ6
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

2585118:FMF02 RS00790
gene id: 2585118:FMF02_RS00790
uniprot id: A0A3D3YJ09
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

2585118:FMF02 RS01870
gene id: 2585118:FMF02_RS01870
uniprot id: A0A4Y1WQK1
names: Similarity
messages: Belongs to the ParB family.

2585118:FMF02 RS02455
gene id: 2585118:FMF02_RS02455
uniprot id: A0A4Y1WPZ2
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

2585118:FMF02 RS05125
gene id: 2585118:FMF02_RS05125
uniprot id: A0A4Y1XRB2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

2585118:FMF02 RS01410
gene id: 2585118:FMF02_RS01410
uniprot id: A0A3D2BEU9
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

2585118:FMF02 RS12035
gene id: 2585118:FMF02_RS12035
uniprot id: A0A4Y1WW53
names: Similarity
messages: Belongs to the thioredoxin family.

2585118:FMF02 RS13370
gene id: 2585118:FMF02_RS13370
uniprot id: A0A4Y1WWJ6
names: Similarity
messages: Belongs to the SufE family.

2585118:FMF02 RS10560
gene id: 2585118:FMF02_RS10560
uniprot id: A0A4Y1XLT2
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

2585118:FMF02 RS05080
gene id: 2585118:FMF02_RS05080
uniprot id: A0A3D3YPK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

2585118:FMF02 RS07475
gene id: 2585118:FMF02_RS07475
uniprot id: A0A3D3YMP1
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

2585118:FMF02 RS03875
gene id: 2585118:FMF02_RS03875
uniprot id: A0A4Y1XQA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane

2585118:FMF02 RS06835
gene id: 2585118:FMF02_RS06835
uniprot id: A0A4Y1WV78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

2585118:FMF02 RS01110
gene id: 2585118:FMF02_RS01110
uniprot id: A0A4Y1WQV2
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2585118:FMF02 RS08370
gene id: 2585118:FMF02_RS08370
uniprot id: A0A4Y1WTB8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2585118:FMF02 RS12725
gene id: 2585118:FMF02_RS12725
uniprot id: A0A4Y1WW29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

2585118:FMF02 RS09165
gene id: 2585118:FMF02_RS09165
uniprot id: A0A4Y1WW42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

2585118:FMF02 RS06495
gene id: 2585118:FMF02_RS06495
uniprot id: A0A4Y1WSC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

2585118:FMF02 RS03545
gene id: 2585118:FMF02_RS03545
uniprot id: A0A3D3YQJ0
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

2585118:FMF02 RS05150
gene id: 2585118:FMF02_RS05150
uniprot id: A0A4Y1WUB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

2585118:FMF02 RS07725
gene id: 2585118:FMF02_RS07725
uniprot id: A0A4Y1XJW7
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

2585118:FMF02 RS03350
gene id: 2585118:FMF02_RS03350
uniprot id: A0A3D3YN75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

2585118:FMF02 RS03840
gene id: 2585118:FMF02_RS03840
uniprot id: A0A4Y1WT50
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL31 family.

2585118:FMF02 RS09980
gene id: 2585118:FMF02_RS09980
uniprot id: A0A3D2BCQ8
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

2585118:FMF02 RS12380
gene id: 2585118:FMF02_RS12380
uniprot id: A0A3D3YNS3
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS06725
gene id: 2585118:FMF02_RS06725
uniprot id: A0A4Y1WT24
names: Similarity
messages: Belongs to the RecJ family.

2585118:FMF02 RS12625
gene id: 2585118:FMF02_RS12625
uniprot id: A0A4Y1WW00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

2585118:FMF02 RS05925
gene id: 2585118:FMF02_RS05925
uniprot id: A0A4Y1WS13
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2585118:FMF02 RS08415
gene id: 2585118:FMF02_RS08415
uniprot id: A0A3D3YJW8
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

2585118:FMF02 RS09875
gene id: 2585118:FMF02_RS09875
uniprot id: A0A3D2BEZ4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

2585118:FMF02 RS05170
gene id: 2585118:FMF02_RS05170
uniprot id: A0A4Y1WS31
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

2585118:FMF02 RS01550
gene id: 2585118:FMF02_RS01550
uniprot id: A0A4Y1XT10
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS06085
gene id: 2585118:FMF02_RS06085
uniprot id: A0A3D2BEL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

2585118:FMF02 RS03865
gene id: 2585118:FMF02_RS03865
uniprot id: A0A4Y1WSC7
names: Similarity
messages: Belongs to the arginase family.

2585118:FMF02 RS01420
gene id: 2585118:FMF02_RS01420
uniprot id: A0A4Y1WS49
names: Similarity
messages: Belongs to the UPF0758 family.

2585118:FMF02 RS03560
gene id: 2585118:FMF02_RS03560
uniprot id: A0A4Y1XS20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

2585118:FMF02 RS12800
gene id: 2585118:FMF02_RS12800
uniprot id: A0A3D3YQ43
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2585118:FMF02 RS02985
gene id: 2585118:FMF02_RS02985
uniprot id: A0A4Y1WSP4
names: Similarity
messages: Belongs to the sigma-54 factor family.

2585118:FMF02 RS01530
gene id: 2585118:FMF02_RS01530
uniprot id: A0A4Y1WSF3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2585118:FMF02 RS02390
gene id: 2585118:FMF02_RS02390
uniprot id: A0A4Y1WQV0
names: Subcellular Location Annotation
messages: Membrane

2585118:FMF02 RS02975
gene id: 2585118:FMF02_RS02975
uniprot id: A0A4Y1WR41
names: Similarity
messages: Belongs to the transglycosylase Slt family.

2585118:FMF02 RS06090
gene id: 2585118:FMF02_RS06090
uniprot id: A0A3D3YP79
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

2585118:FMF02 RS05185
gene id: 2585118:FMF02_RS05185
uniprot id: A0A4Y1WSK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

2585118:FMF02 RS09985
gene id: 2585118:FMF02_RS09985
uniprot id: A0A4Y1WUB5
names: Similarity
messages: Belongs to the fabD family.

2585118:FMF02 RS06410
gene id: 2585118:FMF02_RS06410
uniprot id: A0A3D3YLF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

2585118:FMF02 RS06140
gene id: 2585118:FMF02_RS06140
uniprot id: A0A3D3YK97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

2585118:FMF02 RS06905
gene id: 2585118:FMF02_RS06905
uniprot id: A0A3D2BBM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane