243274:THEMA RS02480
gene id: 243274:THEMA_RS02480
uniprot id: G4FE24
uniprot id: Q9WYS7
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

243274:THEMA RS05500
gene id: 243274:THEMA_RS05500
uniprot id: G4FGC0
uniprot id: Q9X256
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

243274:THEMA RS06830
gene id: 243274:THEMA_RS06830
uniprot id: Q9X1I7
uniprot id: R4NRH3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

243274:THEMA RS06465
gene id: 243274:THEMA_RS06465
uniprot id: Q9X1N4
uniprot id: R4NRN5
names: Similarity
messages: Belongs to the polysaccharide synthase family.

243274:THEMA RS01700
gene id: 243274:THEMA_RS01700
uniprot id: Q9WZ61
uniprot id: R4NQM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS02305
gene id: 243274:THEMA_RS02305
uniprot id: Q01969
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell outer membrane
messages: Homotetramer.
messages: Links the outer membrane to the inner membrane. Long fibrous protein that could serve to separate the two membranes.

243274:THEMA RS00715
gene id: 243274:THEMA_RS00715
uniprot id: G4FD37
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS05095
gene id: 243274:THEMA_RS05095
uniprot id: Q9X2D1
uniprot id: R4NU38
names: Similarity
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.

243274:THEMA RS02405
gene id: 243274:THEMA_RS02405
uniprot id: G4FE13
uniprot id: P29396
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the 50S ribosomal subunit; present in 6 copies per ribosome. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which 3 L12 dimers bind in a sequential fashion.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

243274:THEMA RS06695
gene id: 243274:THEMA_RS06695
uniprot id: G4FFP2
uniprot id: Q9X1J3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

243274:THEMA RS08275
gene id: 243274:THEMA_RS08275
uniprot id: Q9X0S2
uniprot id: R4NSB2
names: Similarity
messages: Belongs to the glycosyl hydrolase 42 family.

243274:THEMA RS05305
gene id: 243274:THEMA_RS05305
uniprot id: Q9X292
uniprot id: R4P1X7
names: Similarity
messages: Belongs to the asp23 family.

243274:THEMA RS09065
gene id: 243274:THEMA_RS09065
uniprot id: G4FEV7
uniprot id: Q9X0D1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS02815
gene id: 243274:THEMA_RS02815
uniprot id: G4FHT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

243274:THEMA RS00375
gene id: 243274:THEMA_RS00375
uniprot id: Q9WZV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

243274:THEMA RS07000
gene id: 243274:THEMA_RS07000
uniprot id: G4FFI1
uniprot id: Q9X1F8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: Each G (guanine nucleotide-binding) domain has activity on its own; domain 1 is twice as active as domain 2. The G domains do not interact, instead each contacts the C-terminal KH-like domain which lies between them.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity). Has GTPase activity but no ATPase activity. GTP, GDP, and dGTP but not GMP, ATP, CTP, and UTP compete for GTP binding.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

243274:THEMA RS04975
gene id: 243274:THEMA_RS04975
uniprot id: G4FGM3
uniprot id: G4XU76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

243274:THEMA RS01750
gene id: 243274:THEMA_RS01750
uniprot id: Q9WZ52
uniprot id: R4NQL4
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

243274:THEMA RS02475
gene id: 243274:THEMA_RS02475
uniprot id: Q9WYS8
uniprot id: R4NY74
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS00190
gene id: 243274:THEMA_RS00190
uniprot id: G4FCT6
uniprot id: Q9WZZ1
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS09600
gene id: 243274:THEMA_RS09600
uniprot id: Q9X032
uniprot id: R4NRK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS09270
gene id: 243274:THEMA_RS09270
uniprot id: Q9X095
names: Similarity
messages: Belongs to the UPF0332 family.

243274:THEMA RS07435
gene id: 243274:THEMA_RS07435
uniprot id: Q9X184
uniprot id: R4NR68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

243274:THEMA RS06410
gene id: 243274:THEMA_RS06410
uniprot id: G4FFU7
uniprot id: Q9X1P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

243274:THEMA RS05240
gene id: 243274:THEMA_RS05240
uniprot id: G4FGH1
uniprot id: Q9X2A4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically inhibited by arginine.
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm
messages: Homohexamer.

243274:THEMA RS06955
gene id: 243274:THEMA_RS06955
uniprot id: Q9X1G6
uniprot id: R4NRF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.
messages: Cell inner membrane
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component, RibU, BioY), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component) upon coexpression in E.coli. A stable subcomplex with both A and T components are also isolated. This complex interacts with at least 2 substrate-specific components, BioY and RibU.
messages: Membrane
messages: Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.
messages: Substrate-binding (S) component of an energy-coupling factor (ECF) ABC-transporter complex. Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins (Probable). Expression of the complex plus RibU in E.coli allows riboflavin uptake; uptake does not occur in the absence of RibU or the EcfA1A2T complex.

243274:THEMA RS08890
gene id: 243274:THEMA_RS08890
uniprot id: Q9X0G5
uniprot id: R4NZX0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

243274:THEMA RS06335
gene id: 243274:THEMA_RS06335
uniprot id: G4FFW2
uniprot id: Q9X1R0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS05595
gene id: 243274:THEMA_RS05595
uniprot id: G4FGA2
uniprot id: Q9X240
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

243274:THEMA RS05530
gene id: 243274:THEMA_RS05530
uniprot id: G4FGB4
uniprot id: Q9X251
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

243274:THEMA RS05450
gene id: 243274:THEMA_RS05450
uniprot id: Q9X266
uniprot id: R4NTX8
names: Similarity
messages: Belongs to the threonine aldolase family.

243274:THEMA RS08660
gene id: 243274:THEMA_RS08660
uniprot id: G4FEM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS05115
gene id: 243274:THEMA_RS05115
uniprot id: Q9X2C7
uniprot id: R4P2A1
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

243274:THEMA RS04090
gene id: 243274:THEMA_RS04090
uniprot id: Q9WXY8
uniprot id: R4NXC0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

243274:THEMA RS08520
gene id: 243274:THEMA_RS08520
uniprot id: Q9X0N2
uniprot id: R4P046
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

243274:THEMA RS07700
gene id: 243274:THEMA_RS07700
uniprot id: Q9X138
uniprot id: R4P0X4
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

243274:THEMA RS05085
gene id: 243274:THEMA_RS05085
uniprot id: Q9X2D4
uniprot id: R4P4A5
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

243274:THEMA RS01365
gene id: 243274:THEMA_RS01365
uniprot id: Q9WZC8
uniprot id: R4NPC0
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

243274:THEMA RS04770
gene id: 243274:THEMA_RS04770
uniprot id: Q9X2I5
uniprot id: R4NU99
names: Similarity
messages: Belongs to the UPF0047 family.

243274:THEMA RS06850
gene id: 243274:THEMA_RS06850
uniprot id: G4FFL1
uniprot id: Q9X1I4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

243274:THEMA RS00575
gene id: 243274:THEMA_RS00575
uniprot id: Q9WZS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Cell membrane
messages: Multidrug efflux pump.

243274:THEMA RS05700
gene id: 243274:THEMA_RS05700
uniprot id: G4FG81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

243274:THEMA RS05920
gene id: 243274:THEMA_RS05920
uniprot id: G4FG40
uniprot id: Q9X1Y4
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

243274:THEMA RS00355
gene id: 243274:THEMA_RS00355
uniprot id: G4FCW8
uniprot id: Q9WZW0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

243274:THEMA RS03580
gene id: 243274:THEMA_RS03580
uniprot id: G4FHD9
uniprot id: Q9WY68
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

243274:THEMA RS09465
gene id: 243274:THEMA_RS09465
uniprot id: G4FF30
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

243274:THEMA RS03070
gene id: 243274:THEMA_RS03070
uniprot id: Q9WYG2
uniprot id: R4NND3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

243274:THEMA RS06750
gene id: 243274:THEMA_RS06750
uniprot id: P46772
uniprot id: R4NT51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

243274:THEMA RS06035
gene id: 243274:THEMA_RS06035
uniprot id: G4FG17
uniprot id: Q9X1W3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

243274:THEMA RS01230
gene id: 243274:THEMA_RS01230
uniprot id: G4FDD7
uniprot id: Q9WZF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

243274:THEMA RS01065
gene id: 243274:THEMA_RS01065
uniprot id: G4FDA4
uniprot id: Q9WZH8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

243274:THEMA RS06535
gene id: 243274:THEMA_RS06535
uniprot id: Q9X1M1
uniprot id: R4P1F4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

243274:THEMA RS04610
gene id: 243274:THEMA_RS04610
uniprot id: Q9WXN7
uniprot id: R4NZC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS05690
gene id: 243274:THEMA_RS05690
uniprot id: Q9X222
uniprot id: R4P3Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

243274:THEMA RS06155
gene id: 243274:THEMA_RS06155
uniprot id: G4FFZ3
uniprot id: Q9X1U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

243274:THEMA RS04140
gene id: 243274:THEMA_RS04140
uniprot id: Q9WXX8
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily.
messages: Part of an ATP-driven transport system TM_0123/TM_0124/TM_0125 for a metal. Probably responsible for energy coupling to the transport system.

243274:THEMA RS00640
gene id: 243274:THEMA_RS00640
uniprot id: Q9WZQ9
uniprot id: R4P1H7
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

243274:THEMA RS00230
gene id: 243274:THEMA_RS00230
uniprot id: G4FCU4
uniprot id: Q9WZY3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Inhibited by iodoacetamide in a pH-dependent manner.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. Has weak activity with succinyl-CoA as the acyl donor.

243274:THEMA RS07990
gene id: 243274:THEMA_RS07990
uniprot id: G4FE95
uniprot id: Q9X0Y0
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS03720
gene id: 243274:THEMA_RS03720
uniprot id: Q9WY40
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the TtcA family. TtuA subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe with a free coordination site may bind a small ligand, such as exogenous sulfide, thus acting as a sulfur carrier.
messages: Catalyzes the ATP-dependent 2-thiolation of 5-methyluridine residue at position 54 in the T loop of tRNAs, leading to 5-methyl-2-thiouridine (m(5)s(2)U or s(2)T) (PubMed:28655838). This modification allows thermal stabilization of tRNAs in thermophilic microorganisms, and is required for cell growth at high temperatures (By similarity). Can use free sulfide as sulfur source in vitro (PubMed:28655838).
messages: Homodimer.
messages: In TtuA from T.thermophilus, the sulfur inserted into the nucleoside comes from the C-terminal thiocarboxylate of TtuB, but there is no TtuB ortholog in T.maritima.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

243274:THEMA RS06995
gene id: 243274:THEMA_RS06995
uniprot id: G4FFI2
uniprot id: Q9X1F9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

243274:THEMA RS06970
gene id: 243274:THEMA_RS06970
uniprot id: G4FFI7
uniprot id: Q9X1G3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Binds two Mg(2+) per subunit.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

243274:THEMA RS04035
gene id: 243274:THEMA_RS04035
uniprot id: G4FH59
uniprot id: Q9WXZ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Forms an hexamer composed of two TsaB, TsaD and TsaE trimers.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

243274:THEMA RS01810
gene id: 243274:THEMA_RS01810
uniprot id: Q9WZ42
uniprot id: R4NP16
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

243274:THEMA RS07820
gene id: 243274:THEMA_RS07820
uniprot id: G4FE63
uniprot id: Q9X112
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

243274:THEMA RS05950
gene id: 243274:THEMA_RS05950
uniprot id: Q9X1X8
uniprot id: R4P3T6
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

243274:THEMA RS07165
gene id: 243274:THEMA_RS07165
uniprot id: G4FFE9
uniprot id: O33833
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.
messages: Hydrolysis of sucrose, raffinose, inulin and levan. Specific for the fructose moiety and the beta-anomeric configuration of the glycosidic linkages of its substrates. The enzyme released fructose from sucrose and raffinose, and the fructose polymer inulin is hydrolyzed quantitatively in an exo-type fashion.

243274:THEMA RS04415
gene id: 243274:THEMA_RS04415
uniprot id: G4FGY4
uniprot id: Q9WXS4
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

243274:THEMA RS07940
gene id: 243274:THEMA_RS07940
uniprot id: Q9X0Z0
uniprot id: R4P0T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS02595
gene id: 243274:THEMA_RS02595
uniprot id: G4FHY2
uniprot id: Q9WYQ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone).

243274:THEMA RS09125
gene id: 243274:THEMA_RS09125
uniprot id: Q9X0B9
uniprot id: R4P023
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS08770
gene id: 243274:THEMA_RS08770
uniprot id: G4FEP9
uniprot id: Q9X0I3
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

243274:THEMA RS03445
gene id: 243274:THEMA_RS03445
uniprot id: G4FHG6
uniprot id: Q9WY94
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

243274:THEMA RS05515
gene id: 243274:THEMA_RS05515
uniprot id: Q9X253
uniprot id: R4P448
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

243274:THEMA RS05415
gene id: 243274:THEMA_RS05415
uniprot id: Q9X273
uniprot id: R4P461
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

243274:THEMA RS00835
gene id: 243274:THEMA_RS00835
uniprot id: G4FD60
uniprot id: Q9WZM2
names: Similarity
messages: Belongs to the UPF0145 family.

243274:THEMA RS07355
gene id: 243274:THEMA_RS07355
uniprot id: Q9X198
uniprot id: R4P0S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS08480
gene id: 243274:THEMA_RS08480
uniprot id: G4FEJ1
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS04875
gene id: 243274:THEMA_RS04875
uniprot id: Q9X2G6
uniprot id: R4NSK1
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

243274:THEMA RS01855
gene id: 243274:THEMA_RS01855
uniprot id: Q9WZ33
uniprot id: R4NQI8
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS02440
gene id: 243274:THEMA_RS02440
uniprot id: G4FE19
uniprot id: P35873
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

243274:THEMA RS06770
gene id: 243274:THEMA_RS06770
uniprot id: G4FFM7
uniprot id: P38508
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

243274:THEMA RS07310
gene id: 243274:THEMA_RS07310
uniprot id: G4FFC3
uniprot id: Q9X1A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

243274:THEMA RS04250
gene id: 243274:THEMA_RS04250
uniprot id: Q9WXV7
uniprot id: R4NMQ7
names: Similarity
messages: Belongs to the BMP lipoprotein family.

243274:THEMA RS05245
gene id: 243274:THEMA_RS05245
uniprot id: G4FGH0
uniprot id: Q9X2A3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

243274:THEMA RS08140
gene id: 243274:THEMA_RS08140
uniprot id: Q9X0U9
uniprot id: R4P2R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS07980
gene id: 243274:THEMA_RS07980
uniprot id: G4FE93
uniprot id: Q9X0Y2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Cytoplasm
messages: Homodimer.

243274:THEMA RS01340
gene id: 243274:THEMA_RS01340
uniprot id: Q9WZD3
uniprot id: R4NPC5
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

243274:THEMA RS07080
gene id: 243274:THEMA_RS07080
uniprot id: R4NRC6
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

243274:THEMA RS04455
gene id: 243274:THEMA_RS04455
uniprot id: G4FGX6
uniprot id: Q60037
names: Domain
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.
messages: The C-terminal CBM-CenC domains mediate the binding of XynA to microcrystalline cellulose. CBM-CenC 2 alone can also promote cellulose binding.

243274:THEMA RS05005
gene id: 243274:THEMA_RS05005
uniprot id: Q9X2F1
uniprot id: R4P220
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

243274:THEMA RS05050
gene id: 243274:THEMA_RS05050
uniprot id: G4FGK8
uniprot id: Q9X2E1
names: Function
names: Similarity
messages: Belongs to the type-2 OGG1 family.
messages: Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).

243274:THEMA RS02670
gene id: 243274:THEMA_RS02670
uniprot id: G4FHW7
uniprot id: Q9WYN9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

243274:THEMA RS01690
gene id: 243274:THEMA_RS01690
uniprot id: G4FDM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

243274:THEMA RS04830
gene id: 243274:THEMA_RS04830
uniprot id: G4FGQ2
uniprot id: Q9X2H4
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

243274:THEMA RS09900
gene id: 243274:THEMA_RS09900
uniprot id: G4FDM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS02110
gene id: 243274:THEMA_RS02110
uniprot id: G4FDV7
uniprot id: Q9WYY4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

243274:THEMA RS05055
gene id: 243274:THEMA_RS05055
uniprot id: G4FGK7
uniprot id: Q9X2E0
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

243274:THEMA RS06870
gene id: 243274:THEMA_RS06870
uniprot id: G4FFK7
uniprot id: P38527
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS00635
gene id: 243274:THEMA_RS00635
uniprot id: G4FD21
uniprot id: Q9WZR0
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS09570
gene id: 243274:THEMA_RS09570
uniprot id: Q9X038
uniprot id: R4NZU0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

243274:THEMA RS03680
gene id: 243274:THEMA_RS03680
uniprot id: R4NXJ6
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

243274:THEMA RS02565
gene id: 243274:THEMA_RS02565
uniprot id: Q9WYR0
uniprot id: R4NQ60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell membrane
messages: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.

243274:THEMA RS06310
gene id: 243274:THEMA_RS06310
uniprot id: G4FFW7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

243274:THEMA RS03660
gene id: 243274:THEMA_RS03660
uniprot id: G4FHC3
uniprot id: Q9WY52
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate. Strongly inhibited by diphosphate, triphosphate and polyphosphate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mg(2+). Mg(2+) can partially be replaced by Mn(2+) and Fe(2+).

243274:THEMA RS04380
gene id: 243274:THEMA_RS04380
uniprot id: Q9WXT1
uniprot id: R4NX63
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

243274:THEMA RS08735
gene id: 243274:THEMA_RS08735
uniprot id: Q9X0J0
uniprot id: R4NS22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS06160
gene id: 243274:THEMA_RS06160
uniprot id: G4FFZ2
uniprot id: Q9X1U0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS05600
gene id: 243274:THEMA_RS05600
uniprot id: G4FGA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

243274:THEMA RS08815
gene id: 243274:THEMA_RS08815
uniprot id: G4FEQ7
uniprot id: Q9X0H5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

243274:THEMA RS07895
gene id: 243274:THEMA_RS07895
uniprot id: G4FE76
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

243274:THEMA RS02335
gene id: 243274:THEMA_RS02335
uniprot id: G4FDZ8
uniprot id: Q9WYU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

243274:THEMA RS06740
gene id: 243274:THEMA_RS06740
uniprot id: G4FFN3
uniprot id: P38520
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

243274:THEMA RS02885
gene id: 243274:THEMA_RS02885
uniprot id: Q9WYJ8
uniprot id: R4NQ07
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

243274:THEMA RS03455
gene id: 243274:THEMA_RS03455
uniprot id: Q9WY92
uniprot id: R4NXR6
names: Similarity
messages: Belongs to the DprA/Smf family.

243274:THEMA RS08760
gene id: 243274:THEMA_RS08760
uniprot id: G4FEP7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

243274:THEMA RS03465
gene id: 243274:THEMA_RS03465
uniprot id: Q9WY90
uniprot id: R4NY28
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

243274:THEMA RS06815
gene id: 243274:THEMA_RS06815
uniprot id: G4FFL8
uniprot id: Q9X1J0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

243274:THEMA RS04015
gene id: 243274:THEMA_RS04015
uniprot id: G4FH63
uniprot id: Q9WXZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

243274:THEMA RS02625
gene id: 243274:THEMA_RS02625
uniprot id: Q9WYP8
uniprot id: R4NY47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

243274:THEMA RS06440
gene id: 243274:THEMA_RS06440
uniprot id: G4FFU1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

243274:THEMA RS04180
gene id: 243274:THEMA_RS04180
uniprot id: Q9WXX1
uniprot id: R4NXA5
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

243274:THEMA RS09230
gene id: 243274:THEMA_RS09230
uniprot id: G4FEY9
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS03665
gene id: 243274:THEMA_RS03665
uniprot id: Q9WY51
uniprot id: R4NXW0
names: Activity Regulation
names: Similarity
names: Subunit
messages: Allosterically activated by AMP and inhibited by ATP.
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

243274:THEMA RS02035
gene id: 243274:THEMA_RS02035
uniprot id: G4FDU3
uniprot id: Q9WYZ8
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

243274:THEMA RS06630
gene id: 243274:THEMA_RS06630
uniprot id: Q9X1K6
uniprot id: R4NRK9
names: Similarity
messages: Belongs to the aspartokinase family.

243274:THEMA RS09045
gene id: 243274:THEMA_RS09045
uniprot id: Q9X0D5
uniprot id: R4P251
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS07270
gene id: 243274:THEMA_RS07270
uniprot id: G4FFC9
uniprot id: Q9X1B3
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

243274:THEMA RS06745
gene id: 243274:THEMA_RS06745
uniprot id: P38511
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

243274:THEMA RS04355
gene id: 243274:THEMA_RS04355
uniprot id: G4FGZ6
uniprot id: Q9WXT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

243274:THEMA RS06950
gene id: 243274:THEMA_RS06950
uniprot id: G4FFJ1
uniprot id: Q9X1G7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

243274:THEMA RS01640
gene id: 243274:THEMA_RS01640
uniprot id: G4FDL5
uniprot id: Q9WZ73
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS08300
gene id: 243274:THEMA_RS08300
uniprot id: G4FEF6
uniprot id: P56838
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm

243274:THEMA RS04070
gene id: 243274:THEMA_RS04070
uniprot id: G4FH53
uniprot id: Q56320
names: Similarity
names: Subunit
messages: Belongs to the TrpF family.
messages: Homodimer.

243274:THEMA RS03165
gene id: 243274:THEMA_RS03165
uniprot id: Q9WYE4
uniprot id: R4NY73
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

243274:THEMA RS06400
gene id: 243274:THEMA_RS06400
uniprot id: Q9X1P7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

243274:THEMA RS06825
gene id: 243274:THEMA_RS06825
uniprot id: Q9X1I8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

243274:THEMA RS04330
gene id: 243274:THEMA_RS04330
uniprot id: G4FH01
uniprot id: Q9WXU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

243274:THEMA RS08180
gene id: 243274:THEMA_RS08180
uniprot id: Q9X0U1
uniprot id: R4NQU1
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

243274:THEMA RS04210
gene id: 243274:THEMA_RS04210
uniprot id: Q9WXW5
uniprot id: R4NZK7
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

243274:THEMA RS05260
gene id: 243274:THEMA_RS05260
uniprot id: G4FGG7
uniprot id: Q9X2A1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS07345
gene id: 243274:THEMA_RS07345
uniprot id: Q9X1A0
uniprot id: R4NSV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

243274:THEMA RS02290
gene id: 243274:THEMA_RS02290
uniprot id: G4FDZ0
uniprot id: Q9WYV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

243274:THEMA RS07285
gene id: 243274:THEMA_RS07285
uniprot id: Q9X1B0
uniprot id: R4NSV9
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS04685
gene id: 243274:THEMA_RS04685
uniprot id: O05650
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

243274:THEMA RS01130
gene id: 243274:THEMA_RS01130
uniprot id: G4FDB7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

243274:THEMA RS01925
gene id: 243274:THEMA_RS01925
uniprot id: G4FDS1
uniprot id: Q9WZ20
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS00085
gene id: 243274:THEMA_RS00085
uniprot id: Q9X012
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

243274:THEMA RS03155
gene id: 243274:THEMA_RS03155
uniprot id: Q9WYE6
uniprot id: R4NXW2
names: Similarity
messages: Belongs to the glycosyl hydrolase 42 family.

243274:THEMA RS09635
gene id: 243274:THEMA_RS09635
uniprot id: G4FF63
uniprot id: P46797
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
messages: Monomer.

243274:THEMA RS04325
gene id: 243274:THEMA_RS04325
uniprot id: G4FH02
uniprot id: Q9WXU2
names: Similarity
messages: Belongs to the MEMO1 family.

243274:THEMA RS02845
gene id: 243274:THEMA_RS02845
uniprot id: G4FHT3
uniprot id: Q9WW19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

243274:THEMA RS08715
gene id: 243274:THEMA_RS08715
uniprot id: Q9X0J4
uniprot id: R4NQI6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

243274:THEMA RS08005
gene id: 243274:THEMA_RS08005
uniprot id: G4FE98
names: Similarity
messages: Belongs to the GARS family.

243274:THEMA RS02835
gene id: 243274:THEMA_RS02835
uniprot id: G4FHT5
uniprot id: Q9WYK6
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock (By similarity).
messages: By stress conditions e.g. heat shock.

243274:THEMA RS09115
gene id: 243274:THEMA_RS09115
uniprot id: Q9X0C1
uniprot id: R4NZT9
names: Similarity
messages: Belongs to the ArsC family.

243274:THEMA RS02640
gene id: 243274:THEMA_RS02640
uniprot id: Q9WYP5
names: Function
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.
messages: Catalyzes the NAD(+)-dependent oxidation of myo-inositol (MI) to 2-keto-myo-inositol (scyllo-inosose), and thus probably functions in a myo-inositol degradation pathway together with IolM, IolN and IolO. Has no activity with scyllo-inositol and much reduced activity (78-fold lower catalytic efficiency) with 1D-chiro-inositol.

243274:THEMA RS09020
gene id: 243274:THEMA_RS09020
uniprot id: Q9X0E0
uniprot id: R4P256
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

243274:THEMA RS00090
gene id: 243274:THEMA_RS00090
uniprot id: Q9X011
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

243274:THEMA RS02520
gene id: 243274:THEMA_RS02520
uniprot id: Q9WYR9
uniprot id: R4NNM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

243274:THEMA RS08015
gene id: 243274:THEMA_RS08015
uniprot id: Q9X0X5
uniprot id: R4P0S2
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS00890
gene id: 243274:THEMA_RS00890
uniprot id: Q9WZL1
uniprot id: R4P1E7
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

243274:THEMA RS00490
gene id: 243274:THEMA_RS00490
uniprot id: Q9WZT7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. MtaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Cytoplasm

243274:THEMA RS06980
gene id: 243274:THEMA_RS06980
uniprot id: Q9X1G2
uniprot id: R4NRE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

243274:THEMA RS09080
gene id: 243274:THEMA_RS09080
uniprot id: G4FEW0
uniprot id: Q9X0C8
names: Activity Regulation
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Activated by the binding of either IGP or PRFAR to the active site of HisF.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

243274:THEMA RS06200
gene id: 243274:THEMA_RS06200
uniprot id: Q9X1T2
uniprot id: R4P3M7
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

243274:THEMA RS03650
gene id: 243274:THEMA_RS03650
uniprot id: G4FHC5
uniprot id: Q9WY54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

243274:THEMA RS06085
gene id: 243274:THEMA_RS06085
uniprot id: Q9X1V3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CheC family.
messages: Homodimer.
messages: Involved in restoring normal CheY-P levels by dephosphorylating CheY-P. It has a greater activity than CheC.

243274:THEMA RS01905
gene id: 243274:THEMA_RS01905
uniprot id: G4FDR7
uniprot id: Q9WZ24
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

243274:THEMA RS06860
gene id: 243274:THEMA_RS06860
uniprot id: G4FFK9
uniprot id: Q9X1I2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

243274:THEMA RS05705
gene id: 243274:THEMA_RS05705
uniprot id: Q9X219
uniprot id: R4NS39
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

243274:THEMA RS00065
gene id: 243274:THEMA_RS00065
uniprot id: G4FCR2
uniprot id: Q9X016
names: Similarity
messages: Belongs to the UPF0111 family.

243274:THEMA RS02730
gene id: 243274:THEMA_RS02730
uniprot id: Q9WYM8
uniprot id: R4NY27
names: Similarity
messages: Belongs to the glutamate synthase family.

243274:THEMA RS00590
gene id: 243274:THEMA_RS00590
uniprot id: Q9WZR9
uniprot id: R4P1I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS00580
gene id: 243274:THEMA_RS00580
uniprot id: Q9WZS1
uniprot id: R4NPS6
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

243274:THEMA RS00255
gene id: 243274:THEMA_RS00255
uniprot id: Q9WZX9
uniprot id: R4P1P0
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS06715
gene id: 243274:THEMA_RS06715
uniprot id: G4FFN8
uniprot id: P38518
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

243274:THEMA RS00695
gene id: 243274:THEMA_RS00695
uniprot id: G4FD33
uniprot id: Q9WZP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

243274:THEMA RS08415
gene id: 243274:THEMA_RS08415
uniprot id: G4FEH8
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

243274:THEMA RS00830
gene id: 243274:THEMA_RS00830
uniprot id: R4NPN9
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS09030
gene id: 243274:THEMA_RS09030
uniprot id: Q9X0D8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

243274:THEMA RS05320
gene id: 243274:THEMA_RS05320
uniprot id: G4FGF5
uniprot id: Q9X289
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

243274:THEMA RS00290
gene id: 243274:THEMA_RS00290
uniprot id: Q9WZX3
uniprot id: R4NRF4
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

243274:THEMA RS09060
gene id: 243274:THEMA_RS09060
uniprot id: G4FEV6
uniprot id: Q9X0D2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

243274:THEMA RS07725
gene id: 243274:THEMA_RS07725
uniprot id: Q9X132
uniprot id: R4P0X0
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS04075
gene id: 243274:THEMA_RS04075
uniprot id: G4FH52
uniprot id: P50909
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

243274:THEMA RS09035
gene id: 243274:THEMA_RS09035
uniprot id: Q9X0D7
uniprot id: R4NQC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity).
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

243274:THEMA RS05325
gene id: 243274:THEMA_RS05325
uniprot id: G4FGF4
uniprot id: Q9X288
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

243274:THEMA RS04580
gene id: 243274:THEMA_RS04580
uniprot id: G4FGV3
uniprot id: Q9WXP3
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

243274:THEMA RS08680
gene id: 243274:THEMA_RS08680
uniprot id: Q9X0K1
uniprot id: R4P0B7
names: Similarity
messages: Belongs to the bacterial secretin family.

243274:THEMA RS00885
gene id: 243274:THEMA_RS00885
uniprot id: G4FD70
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

243274:THEMA RS06100
gene id: 243274:THEMA_RS06100
uniprot id: G4FG04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

243274:THEMA RS02330
gene id: 243274:THEMA_RS02330
uniprot id: G4FDZ7
uniprot id: Q9WYU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: Homohexamer and homododecamer. In the presence of PdxT, forms a dodecamer of heterodimers.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

243274:THEMA RS08800
gene id: 243274:THEMA_RS08800
uniprot id: G4FEQ4
uniprot id: Q9X0H8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

243274:THEMA RS03560
gene id: 243274:THEMA_RS03560
uniprot id: Q9WY71
uniprot id: R4NZY6
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS00395
gene id: 243274:THEMA_RS00395
uniprot id: G4FCX5
uniprot id: Q9WZV3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

243274:THEMA RS08040
gene id: 243274:THEMA_RS08040
uniprot id: G4FEA5
uniprot id: Q9X0X0
names: Similarity
messages: Belongs to the SAICAR synthetase family.

243274:THEMA RS01165
gene id: 243274:THEMA_RS01165
uniprot id: Q56312
names: Cofactor
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY seems to regulate the clockwise (CW) rotation (By similarity).
messages: Phosphorylated by CheA.

243274:THEMA RS06780
gene id: 243274:THEMA_RS06780
uniprot id: G4FFM5
uniprot id: P38517
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

243274:THEMA RS01625
gene id: 243274:THEMA_RS01625
uniprot id: G4FDL2
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.

243274:THEMA RS09630
gene id: 243274:THEMA_RS09630
uniprot id: P56728
names: Caution
messages: Was originally proposed to be fused with TM_0929.

243274:THEMA RS06765
gene id: 243274:THEMA_RS06765
uniprot id: G4FFM8
uniprot id: P38519
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

243274:THEMA RS05395
gene id: 243274:THEMA_RS05395
uniprot id: G4FGE1
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

243274:THEMA RS04320
gene id: 243274:THEMA_RS04320
uniprot id: G4FH03
names: Similarity
messages: Belongs to the bacterial secretin family.

243274:THEMA RS05065
gene id: 243274:THEMA_RS05065
uniprot id: Q9X2D8
uniprot id: R4P2B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

243274:THEMA RS06730
gene id: 243274:THEMA_RS06730
uniprot id: G4FFN5
uniprot id: P38512
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

243274:THEMA RS05580
gene id: 243274:THEMA_RS05580
uniprot id: Q9X243
uniprot id: R4NS90
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS04280
gene id: 243274:THEMA_RS04280
uniprot id: Q9WXV1
uniprot id: R4NX84
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

243274:THEMA RS03085
gene id: 243274:THEMA_RS03085
uniprot id: Q9WYF9
uniprot id: R4NY85
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

243274:THEMA RS03745
gene id: 243274:THEMA_RS03745
uniprot id: G4FHA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

243274:THEMA RS06515
gene id: 243274:THEMA_RS06515
uniprot id: G4FFS7
uniprot id: Q9X1M5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: Periplasm
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

243274:THEMA RS04550
gene id: 243274:THEMA_RS04550
uniprot id: Q9WXP9
uniprot id: R4NMK1
names: Similarity
messages: Belongs to the peptidase M24B family.

243274:THEMA RS04375
gene id: 243274:THEMA_RS04375
uniprot id: Q9WXT2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity stimulated by up to 40% in the presence of divalent cations such as BaCl(2), CaCl(2), MgCl(2) and MnCl(2) at 3 mM concentration, but inhibited by 82-85% in the presence of CdCl(2) and ZnCl(2) at 3 mM concentration.
messages: Belongs to the carbohydrate esterase 7 family.
messages: Cytoplasm
messages: Esterase that removes acetyl groups from a number of O-acetylated small substrates, such as acetylated xylose, short xylo-oligosaccharides and cephalosporin C. Has no activity towards polymeric acetylated xylan, 4-methylumbelliferyl acetate or alpha-naphthyl acetate. Able to catalyze rapid hydrolysis of a range of substrates preferably with acetate groups, independent of the alcohol moiety. Exhibits a narrow selectivity for short chain acyl esters (C2-C3). Displays broad substrate specificity by hydrolyzing acetate at 2, 3, and 4 positions of 4-nitrophenyl-beta-D-xylopyranoside (pNP-Xyl) with similar efficiency. Cannot cleave amide linkages.
messages: Homohexamer, formed by a trimer of dimers. Also exists as a homodimer.

243274:THEMA RS00615
gene id: 243274:THEMA_RS00615
uniprot id: G4FD17
uniprot id: Q9WZR4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

243274:THEMA RS02190
gene id: 243274:THEMA_RS02190
uniprot id: Q9WYW7
uniprot id: R4NYB7
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS03530
gene id: 243274:THEMA_RS03530
uniprot id: G4FHE9
uniprot id: Q9WY77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

243274:THEMA RS06940
gene id: 243274:THEMA_RS06940
uniprot id: G4FFJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

243274:THEMA RS09070
gene id: 243274:THEMA_RS09070
uniprot id: G4FEV8
uniprot id: Q9X0D0
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

243274:THEMA RS04365
gene id: 243274:THEMA_RS04365
uniprot id: Q9WXT4
uniprot id: R4NXH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

243274:THEMA RS03525
gene id: 243274:THEMA_RS03525
uniprot id: Q9WY78
uniprot id: R4NN74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

243274:THEMA RS09355
gene id: 243274:THEMA_RS09355
uniprot id: G4FF12
uniprot id: Q9X078
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

243274:THEMA RS02700
gene id: 243274:THEMA_RS02700
uniprot id: Q9WYN3
uniprot id: R4NY33
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

243274:THEMA RS09470
gene id: 243274:THEMA_RS09470
uniprot id: G4FF31
uniprot id: Q9X054
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

243274:THEMA RS04460
gene id: 243274:THEMA_RS04460
uniprot id: Q9WXR6
uniprot id: R4NZF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS07010
gene id: 243274:THEMA_RS07010
uniprot id: G4FFH9
uniprot id: Q9X1F7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

243274:THEMA RS03900
gene id: 243274:THEMA_RS03900
uniprot id: G4FH86
uniprot id: O51933
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

243274:THEMA RS03815
gene id: 243274:THEMA_RS03815
uniprot id: G4FH98
uniprot id: Q9WY28
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

243274:THEMA RS05505
gene id: 243274:THEMA_RS05505
uniprot id: G4FGB9
uniprot id: Q9X255
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP (By similarity).
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS08515
gene id: 243274:THEMA_RS08515
uniprot id: Q9X0N3
uniprot id: R4NQM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS00920
gene id: 243274:THEMA_RS00920
uniprot id: Q9WZK6
uniprot id: R4P1E3
names: Similarity
messages: Belongs to the peptidase S41A family.

243274:THEMA RS07015
gene id: 243274:THEMA_RS07015
uniprot id: G4FFH8
uniprot id: Q9X1F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

243274:THEMA RS03595
gene id: 243274:THEMA_RS03595
uniprot id: Q9WY65
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (Probable). Expression of the complex plus RibU in E.coli allows riboflavin uptake; uptake does not occur in the absence of RibU or the EcfA1A2T complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell inner membrane
messages: Forms a heterodimer with EcfA1. Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component, RibU, BioY), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component) upon coexpression in E.coli. Stable subcomplexes with both A plus T components can also be isolated. This complex interacts with at least 2 substrate-specific components, BioY and RibU.
messages: Structure 4HLU is probably in the open state.

243274:THEMA RS04345
gene id: 243274:THEMA_RS04345
uniprot id: Q9WXT8
uniprot id: R4NP99
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

243274:THEMA RS03450
gene id: 243274:THEMA_RS03450
uniprot id: Q9WY93
uniprot id: R4NN87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

243274:THEMA RS07705
gene id: 243274:THEMA_RS07705
uniprot id: Q9X137
names: Similarity
messages: Belongs to the UPF0150 family.

243274:THEMA RS00780
gene id: 243274:THEMA_RS00780
uniprot id: Q9WZN2
uniprot id: R4NPP6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.

243274:THEMA RS05645
gene id: 243274:THEMA_RS05645
uniprot id: G4FG92
uniprot id: Q9X231
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

243274:THEMA RS05725
gene id: 243274:THEMA_RS05725
uniprot id: G4FG76
uniprot id: Q9X215
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

243274:THEMA RS07750
gene id: 243274:THEMA_RS07750
uniprot id: Q9X127
uniprot id: R4P0W6
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

243274:THEMA RS07280
gene id: 243274:THEMA_RS07280
uniprot id: Q9X1B1
uniprot id: R4P136
names: Similarity
messages: Belongs to the ClpA/ClpB family.

243274:THEMA RS04675
gene id: 243274:THEMA_RS04675
uniprot id: O05651
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

243274:THEMA RS01280
gene id: 243274:THEMA_RS01280
uniprot id: G4FDE7
names: Similarity
messages: Belongs to the MotB family.

243274:THEMA RS05345
gene id: 243274:THEMA_RS05345
uniprot id: G4FGF0
uniprot id: Q9X284
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

243274:THEMA RS03235
gene id: 243274:THEMA_RS03235
uniprot id: G4FHK8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS03080
gene id: 243274:THEMA_RS03080
uniprot id: Q9WYG0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

243274:THEMA RS05470
gene id: 243274:THEMA_RS05470
uniprot id: Q9X262
uniprot id: R4P247
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MrnC RNase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.

243274:THEMA RS06500
gene id: 243274:THEMA_RS06500
uniprot id: Q9X1M8
uniprot id: R4P176
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

243274:THEMA RS04750
gene id: 243274:THEMA_RS04750
uniprot id: Q9X2I9
uniprot id: R4NSM0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

243274:THEMA RS06725
gene id: 243274:THEMA_RS06725
uniprot id: G4FFN6
uniprot id: P38516
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A protein containing 11 mutations, chosen as amino acids which probably interact with nucleic acids (K140A, E141Q, Q144K, Q147A, S149E, K151delta, K152delta, I155M, P158G, W159E and K160L), gained the ability to regulate the E.coli S10 operon, suggesting it is now able to mediate contacts of L4 with the S10 mRNA leader in E.coli. This mutant protein did not associate any better with E.coli ribosomes however, indicating a separation of residues interacting with rRNA and mRNA.
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.
messages: The structure indicates that the N-terminal domain may bind to the 23S rRNA, while the C-terminal domain may bind to the mRNA, which could then be implicated in transcriptional and translational control of the S10 operon. However, it is not known if the S10 operon is controlled in this fashion in this organism.
messages: This protein only weakly controls expression of the E.coli S10 operon. It is incorporated into E.coli ribosomes, however it is not as firmly associated as the endogenous protein.

243274:THEMA RS06660
gene id: 243274:THEMA_RS06660
uniprot id: Q9X1K0
uniprot id: R4P150
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

243274:THEMA RS06700
gene id: 243274:THEMA_RS06700
uniprot id: G4FFP1
uniprot id: P38526
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

243274:THEMA RS02415
gene id: 243274:THEMA_RS02415
uniprot id: G4FE15
uniprot id: P29393
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

243274:THEMA RS06095
gene id: 243274:THEMA_RS06095
uniprot id: Q9X1V2
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS05655
gene id: 243274:THEMA_RS05655
uniprot id: Q9X229
uniprot id: R4NS51
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

243274:THEMA RS02945
gene id: 243274:THEMA_RS02945
uniprot id: Q9WYI6
uniprot id: R4NXZ1
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS04835
gene id: 243274:THEMA_RS04835
uniprot id: G4FGQ1
uniprot id: P36203
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

243274:THEMA RS08265
gene id: 243274:THEMA_RS08265
uniprot id: Q9X0S4
uniprot id: R4P2L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS09450
gene id: 243274:THEMA_RS09450
uniprot id: Q9X058
uniprot id: R4NQ54
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

243274:THEMA RS04505
gene id: 243274:THEMA_RS04505
uniprot id: Q9WXQ8
uniprot id: R4NX35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

243274:THEMA RS03075
gene id: 243274:THEMA_RS03075
uniprot id: G4FHN9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS06820
gene id: 243274:THEMA_RS06820
uniprot id: G4FFL7
uniprot id: Q9X1I9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

243274:THEMA RS03535
gene id: 243274:THEMA_RS03535
uniprot id: G4FHE8
uniprot id: Q9WY76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

243274:THEMA RS07655
gene id: 243274:THEMA_RS07655
uniprot id: Q9X145
names: Similarity
messages: Belongs to the UPF0150 family.

243274:THEMA RS06790
gene id: 243274:THEMA_RS06790
uniprot id: G4FFM3
uniprot id: Q9ZAE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

243274:THEMA RS08330
gene id: 243274:THEMA_RS08330
uniprot id: G4FEG1
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

243274:THEMA RS00535
gene id: 243274:THEMA_RS00535
uniprot id: G4FD03
uniprot id: Q9WZS8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

243274:THEMA RS02465
gene id: 243274:THEMA_RS02465
uniprot id: G4FE21
uniprot id: Q9WYT0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP or deoxyuridylate) to 2'-deoxythymidine-5'-monophosphate (dTMP or deoxythymidylate) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methylene donor, and NAD(P)H and FADH(2) as the reductant. This reaction is a critical step in DNA biosynthesis (PubMed:12791256, PubMed:19370033). Can also use formaldehyde instead of mTHF as a direct methylene donor for dTMP synthesis. However, the tighter binding of ThyX to mTHF (KD of 4 uM) compared to formaldehyde (KD of 20 mM) confirms that methylene tetrahydrofolate acts as the biological carbon donor for ThyX, serving as a formaldehyde carrier/transporter and thus avoiding genotoxic effects (PubMed:34315871).
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Reaction mechanism involved a direct methylene transfer from mTHF to dUMP (PubMed:23019356). FDTS ionizes N3 of dUMP using the active-site Arg-174, providing a new mechanism for dUMP activation. The phosphate of dUMP is crucial for flavin oxidation, suggesting that it acts as the base that deprotonates C5 of the dUMP-methylene adduct (PubMed:27214228). A later study showed that FAD is first reduced by NADPH. Then, the reduced flavin, FADH(-), reacts with mTHF to form a carbinolamine flavin, which acts as the genuine methylene donor. The flavin carbinolamine can be obtained directly via a CH2O-shunt reaction consisting of a reaction of FADH(-) with free CH2O. Methylene transfer from FAD to dUMP is initiated by an SN2 reaction of activated dUMP and the flavin carbinolamine, leading to water elimination and formation of a transient FAD-CH2-dUMP adduct (PubMed:34315871).

243274:THEMA RS06620
gene id: 243274:THEMA_RS06620
uniprot id: G4FFQ7
uniprot id: Q9X1K8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Uses NADPH as a reductant with much more efficiency than NADH.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Is inhibited by high concentrations of NADH.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

243274:THEMA RS02825
gene id: 243274:THEMA_RS02825
uniprot id: Q9WYK8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PduL family.
messages: Cytoplasm
messages: Formed by 2 beta-barrels, each is capped on both ends by short alpha-helices.
messages: Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.
messages: There are 2 Zn(2+) ions per monomer; Zn(2+) and CoA bind inbetween the 2 domains in each monomer.

243274:THEMA RS03715
gene id: 243274:THEMA_RS03715
uniprot id: Q9WY41
uniprot id: R4NXU9
names: Similarity
messages: Belongs to the ClpA/ClpB family.

243274:THEMA RS03365
gene id: 243274:THEMA_RS03365
uniprot id: Q9WYA5
uniprot id: R4NY42
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.

243274:THEMA RS07230
gene id: 243274:THEMA_RS07230
uniprot id: Q9X1C1
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Involved in the degradation of L-serine via 3-hydroxypyruvate. Catalyzes the non-reversible reduction of 3-hydroxypyruvate to yield D-glycerate.

243274:THEMA RS08320
gene id: 243274:THEMA_RS08320
uniprot id: Q9X0R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Cell membrane

243274:THEMA RS05865
gene id: 243274:THEMA_RS05865
uniprot id: G4FG51
uniprot id: P96112
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit. In contrast to other surE homologs, is essentially inactive with other divalent cations.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Homodimer and possibly homotetramer.
messages: Inhibited by vanadate and tungstate.
messages: Nucleotidase that preferentially dephosphorylates 5'-GMP and 5'-AMP.
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
messages: Was originally annotated as an acid phosphatase (EC 3.1.3.2).

243274:THEMA RS01335
gene id: 243274:THEMA_RS01335
uniprot id: Q9WZD4
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

243274:THEMA RS05640
gene id: 243274:THEMA_RS05640
uniprot id: G4FG93
uniprot id: Q9X232
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

243274:THEMA RS00220
gene id: 243274:THEMA_RS00220
uniprot id: G4FCU2
uniprot id: Q9WZY5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS03140
gene id: 243274:THEMA_RS03140
uniprot id: Q9WYE9
uniprot id: R4NY76
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

243274:THEMA RS05355
gene id: 243274:THEMA_RS05355
uniprot id: G4FGE8
uniprot id: Q9X282
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

243274:THEMA RS02590
gene id: 243274:THEMA_RS02590
uniprot id: G4FHY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS08350
gene id: 243274:THEMA_RS08350
uniprot id: Q9X0R3
uniprot id: R4P0H8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

243274:THEMA RS01285
gene id: 243274:THEMA_RS01285
uniprot id: Q9WZE3
uniprot id: R4NQW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

243274:THEMA RS02955
gene id: 243274:THEMA_RS02955
uniprot id: G4FHR1
uniprot id: Q9WYI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

243274:THEMA RS00805
gene id: 243274:THEMA_RS00805
uniprot id: Q9WZM7
uniprot id: R4NPP0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

243274:THEMA RS01135
gene id: 243274:THEMA_RS01135
uniprot id: Q9WZG5
uniprot id: R4NR00
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS05970
gene id: 243274:THEMA_RS05970
uniprot id: Q60034
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dihydrofolate reductase family.
messages: Homodimer.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).

243274:THEMA RS05720
gene id: 243274:THEMA_RS05720
uniprot id: G4FG77
uniprot id: Q9X216
names: Similarity
messages: Belongs to the RemA family.

243274:THEMA RS06385
gene id: 243274:THEMA_RS06385
uniprot id: G4FFV2
uniprot id: Q9X1Q0
names: Similarity
messages: Belongs to the acylphosphatase family.

243274:THEMA RS05960
gene id: 243274:THEMA_RS05960
uniprot id: G4FG32
uniprot id: Q9X1X6
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Competitively inhibited by L-malate and NH(4)(+).
messages: Homodimer.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. Does not show aspartate oxidase activity. Is also able to catalyze the reverse reaction, i.e. the reductive amination of oxaloacetate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

243274:THEMA RS03565
gene id: 243274:THEMA_RS03565
uniprot id: Q9WY70
uniprot id: R4NY04
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

243274:THEMA RS01895
gene id: 243274:THEMA_RS01895
uniprot id: G4FDR5
uniprot id: Q9WZ26
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

243274:THEMA RS00770
gene id: 243274:THEMA_RS00770
uniprot id: Q9WZN4
uniprot id: R4NZG6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

243274:THEMA RS08290
gene id: 243274:THEMA_RS08290
uniprot id: G4FEF4
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 36 family.
messages: Homodimer.
messages: Hydrolyzes the short-chain alpha-galactosaccharides raffinose, melibiose and stachyose.
messages: Inhibited by hydrolyzation product alpha-galactopyranose and to a lesser extent by beta-galactopyranose, its mutarotational product (PubMed:26005928). Inhibited by synthetic cyclopropyl carbasugars (PubMed:27783466).

243274:THEMA RS08020
gene id: 243274:THEMA_RS08020
uniprot id: Q9X0X4
uniprot id: R4NSJ2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

243274:THEMA RS03040
gene id: 243274:THEMA_RS03040
uniprot id: G4FHP5
uniprot id: Q9WYG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family.
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

243274:THEMA RS07430
gene id: 243274:THEMA_RS07430
uniprot id: Q9X185
uniprot id: R4NST7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

243274:THEMA RS05030
gene id: 243274:THEMA_RS05030
uniprot id: G4FGL2
uniprot id: Q9X2E5
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

243274:THEMA RS07520
gene id: 243274:THEMA_RS07520
uniprot id: Q9X168
uniprot id: R4P2Z3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

243274:THEMA RS05755
gene id: 243274:THEMA_RS05755
uniprot id: G4FG70
uniprot id: O54310
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Monomer.

243274:THEMA RS01845
gene id: 243274:THEMA_RS01845
uniprot id: G4FDQ5
uniprot id: Q9WZ35
names: Similarity
messages: Belongs to the SfsA family.

243274:THEMA RS03340
gene id: 243274:THEMA_RS03340
uniprot id: G4FHI7
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

243274:THEMA RS05735
gene id: 243274:THEMA_RS05735
uniprot id: Q9X213
uniprot id: R4P1L4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS08080
gene id: 243274:THEMA_RS08080
uniprot id: Q9X0W1
uniprot id: R4NQY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS00010
gene id: 243274:THEMA_RS00010
uniprot id: G4FF65
uniprot id: Q9X027
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS06315
gene id: 243274:THEMA_RS06315
uniprot id: G4FFW6
uniprot id: Q9X1R4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer (By similarity). Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved. A single SecA monomer interacts with SecY in the channel.
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

243274:THEMA RS04170
gene id: 243274:THEMA_RS04170
uniprot id: G4FH33
uniprot id: Q7DFA2
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

243274:THEMA RS08585
gene id: 243274:THEMA_RS08585
uniprot id: Q9X0M0
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS02525
gene id: 243274:THEMA_RS02525
uniprot id: Q9WYR8
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

243274:THEMA RS01440
gene id: 243274:THEMA_RS01440
uniprot id: G4FDH9
uniprot id: Q9WZB3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS02935
gene id: 243274:THEMA_RS02935
uniprot id: Q9WYI8
uniprot id: R4NPZ8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

243274:THEMA RS04820
gene id: 243274:THEMA_RS04820
uniprot id: G4FGQ4
uniprot id: Q9X2H6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. The two iron atoms in each cluster are connected via a penta-sulfide bridge.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm
messages: Monomer.

243274:THEMA RS06115
gene id: 243274:THEMA_RS06115
uniprot id: G4FG01
uniprot id: Q9X1U8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

243274:THEMA RS05995
gene id: 243274:THEMA_RS05995
uniprot id: Q9X1X1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a complex with Mre11 (By similarity).
messages: Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site (By similarity).
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer (By similarity).

243274:THEMA RS08485
gene id: 243274:THEMA_RS08485
uniprot id: G4FEJ2
uniprot id: Q9X0N9
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS04860
gene id: 243274:THEMA_RS04860
uniprot id: Q9X2G9
uniprot id: R4P4D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS01745
gene id: 243274:THEMA_RS01745
uniprot id: Q9WZ53
uniprot id: R4NYV5
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS03230
gene id: 243274:THEMA_RS03230
uniprot id: G4FHK9
uniprot id: Q9WYD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Does not show fructose-6-P aldolase activity.

243274:THEMA RS05040
gene id: 243274:THEMA_RS05040
uniprot id: Q9X2E3
uniprot id: R4P2B5
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

243274:THEMA RS01375
gene id: 243274:THEMA_RS01375
uniprot id: G4FDG6
uniprot id: Q9WZC6
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide.

243274:THEMA RS00335
gene id: 243274:THEMA_RS00335
uniprot id: Q9WZW4
uniprot id: R4NZM8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

243274:THEMA RS03250
gene id: 243274:THEMA_RS03250
uniprot id: G4FHK5
uniprot id: Q9WYC7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

243274:THEMA RS01430
gene id: 243274:THEMA_RS01430
uniprot id: G4FDH7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS00080
gene id: 243274:THEMA_RS00080
uniprot id: G4FCR5
uniprot id: Q9X013
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

243274:THEMA RS05025
gene id: 243274:THEMA_RS05025
uniprot id: G4FGL3
uniprot id: Q9X2E6
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

243274:THEMA RS03890
gene id: 243274:THEMA_RS03890
uniprot id: G4FH88
uniprot id: Q9S5X0
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell inner membrane
messages: Has 16 transmembrane helices and a cytoplasmic domain that contains the active site. Pyrophosphate binding is thought to trigger a conformation change that allows Na(+) release. Has at least two binding sites for Na(+) (PubMed:22837527).
messages: Homodimer.
messages: Inhibited by GdCl3. Requires K(+) for maximal activity. K(+) greatly stimulates Na(+) binding. Thermostability depends on the binding of Mg(2+).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

243274:THEMA RS03285
gene id: 243274:THEMA_RS03285
uniprot id: Q9WYC0
uniprot id: R4P026
names: Similarity
messages: Belongs to the FGGY kinase family.

243274:THEMA RS03875
gene id: 243274:THEMA_RS03875
uniprot id: Q9WY21
uniprot id: R4NPI6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

243274:THEMA RS04020
gene id: 243274:THEMA_RS04020
uniprot id: G4FH62
uniprot id: Q9WXZ5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

243274:THEMA RS03570
gene id: 243274:THEMA_RS03570
uniprot id: G4FHE1
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

243274:THEMA RS08755
gene id: 243274:THEMA_RS08755
uniprot id: G4FEP6
uniprot id: Q9X0I6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Probably processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

243274:THEMA RS01005
gene id: 243274:THEMA_RS01005
uniprot id: G4FD93
uniprot id: Q9WZI9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

243274:THEMA RS07955
gene id: 243274:THEMA_RS07955
uniprot id: Q9X0Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

243274:THEMA RS03295
gene id: 243274:THEMA_RS03295
uniprot id: Q9WYB8
uniprot id: R4NPT5
names: Similarity
messages: Belongs to the aldose epimerase family.

243274:THEMA RS06720
gene id: 243274:THEMA_RS06720
uniprot id: G4FFN7
uniprot id: P38515
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

243274:THEMA RS03645
gene id: 243274:THEMA_RS03645
uniprot id: Q9WY55
uniprot id: R4NPL5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

243274:THEMA RS01970
gene id: 243274:THEMA_RS01970
uniprot id: Q9WZ11
uniprot id: R4P0Q9
names: Similarity
messages: Belongs to the class-I fumarase family.

243274:THEMA RS08845
gene id: 243274:THEMA_RS08845
uniprot id: G4FER3
uniprot id: O33925
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS07250
gene id: 243274:THEMA_RS07250
uniprot id: G4FFD3
uniprot id: Q9X1B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS08185
gene id: 243274:THEMA_RS08185
uniprot id: Q9X0U0
uniprot id: R4P0B9
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS03480
gene id: 243274:THEMA_RS03480
uniprot id: Q9WY87
uniprot id: R4NXR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

243274:THEMA RS03400
gene id: 243274:THEMA_RS03400
uniprot id: Q9WY99
uniprot id: R4NN92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

243274:THEMA RS06675
gene id: 243274:THEMA_RS06675
uniprot id: G4FFP6
uniprot id: Q9X1J7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

243274:THEMA RS06585
gene id: 243274:THEMA_RS06585
uniprot id: G4FFR3
uniprot id: Q7DF96
names: Similarity
messages: Belongs to the glycosyl hydrolase 12 (cellulase H) family.

243274:THEMA RS06840
gene id: 243274:THEMA_RS06840
uniprot id: G4FFL3
uniprot id: Q9X1I6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

243274:THEMA RS00015
gene id: 243274:THEMA_RS00015
uniprot id: Q9X026
uniprot id: R4NRJ9
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

243274:THEMA RS01060
gene id: 243274:THEMA_RS01060
uniprot id: G4FDA3
uniprot id: Q9WZH9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS03355
gene id: 243274:THEMA_RS03355
uniprot id: Q9WYA7
uniprot id: R4NXT0
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

243274:THEMA RS07240
gene id: 243274:THEMA_RS07240
uniprot id: G4FFD5
uniprot id: Q9X1B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

243274:THEMA RS06380
gene id: 243274:THEMA_RS06380
uniprot id: Q9X1Q1
uniprot id: R4P1H6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

243274:THEMA RS04485
gene id: 243274:THEMA_RS04485
uniprot id: G4FGX0
uniprot id: P96105
names: Function
names: Similarity
names: Subunit
messages: Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. It catalyzes the cleavage of alpha-(1->2)-glycosidic bond of the 4-O-methyl-D-glucuronic acid side chain of xylan and releases 4-O-methylglucuronic acid from xylan.
messages: Belongs to the glycosyl hydrolase 67 family.
messages: Homodimer.

243274:THEMA RS02630
gene id: 243274:THEMA_RS02630
uniprot id: Q9WYP7
names: Activity Regulation
names: Biotechnology
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the hyi family.
messages: Binds 1 divalent metal cation per subunit. Mn(2+) is the most efficient metal cofactor, but can also use other divalent metal cations such as Ni(2+), Mg(2+), and, to a lesser extent, Co(2+) and Zn(2+), but not Ca(2+), Cu(2+), and Fe(2+).
messages: Catalyzes the reversible epimerization between 5-keto-L-gluconate (5-dehydro-L-gluconate) and D-tagaturonate, and thus probably functions in a myo-inositol degradation pathway together with IolG, IolM and IolN (PubMed:23441918). Is not active on the enantiomer 5-keto-D-gluconate (PubMed:23441918). Was also shown to be a nonphosphorylated sugar isomerase with broad substrate specificity in vitro (PubMed:28258150). Is able to catalyze the reversible C3-epimerization of L-ribulose to L-xylulose, D-ribulose to D-xylulose, D-psicose to D-fructose, and D-tagatose to D-sorbose, with a substrate preference for ketopentoses rather than ketohexoses (PubMed:28258150). Also catalyzes the aldose-ketose isomerization reaction from either D-erythrose or D-threose to D-erythrulose (PubMed:28258150). Exhibits no activity for C4-epimerization of D-tagatose to D-fructose (PubMed:28258150).
messages: High thermostability and very broad substrate specificity of this enzyme make it a potential candidate for the production of rare sugars for the food and pharmaceutical industries.
messages: Homodimer.
messages: Is completely inhibited by EDTA in vitro.

243274:THEMA RS08490
gene id: 243274:THEMA_RS08490
uniprot id: Q9X0N8
uniprot id: R4NQM8
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

243274:THEMA RS03470
gene id: 243274:THEMA_RS03470
uniprot id: Q9WY89
uniprot id: R4NPQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

243274:THEMA RS07865
gene id: 243274:THEMA_RS07865
uniprot id: G4FE70
uniprot id: Q9X105
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Contains an N-terminal DNA-binding domain, followed by a dimerization domain and a C-terminal domain, called the small MutS-related (Smr) domain, which is absent from MutS and contains the endonuclease activity.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity (Probable). Has ATPase activity. Binds to DNA.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.
messages: Homodimer. Interacts with MutL.
messages: Nuclease activity is stimulated by interaction with MutL and inhibited in the presence of non-hydrolytic ATP (ADPnP). ATPase activity is stimulated by DNA.

243274:THEMA RS06225
gene id: 243274:THEMA_RS06225
uniprot id: G4FFX9
uniprot id: Q9X1S7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

243274:THEMA RS05605
gene id: 243274:THEMA_RS05605
uniprot id: Q9X238
uniprot id: R4NS63
names: Similarity
messages: Belongs to the IMPACT family.

243274:THEMA RS02875
gene id: 243274:THEMA_RS02875
uniprot id: G4FHS7
uniprot id: Q9WYJ9
names: Similarity
messages: Belongs to the peptidase M18 family.

243274:THEMA RS06795
gene id: 243274:THEMA_RS06795
uniprot id: G4FFM2
uniprot id: Q9ZAE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

243274:THEMA RS06475
gene id: 243274:THEMA_RS06475
uniprot id: Q9X1N2
uniprot id: R4P3G9
names: Similarity
messages: Belongs to the RecJ family.

243274:THEMA RS03510
gene id: 243274:THEMA_RS03510
uniprot id: Q9WY81
uniprot id: R4NZZ2
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

243274:THEMA RS09505
gene id: 243274:THEMA_RS09505
uniprot id: G4FF38
uniprot id: Q9X049
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS09090
gene id: 243274:THEMA_RS09090
uniprot id: G4FEW2
uniprot id: Q9X0C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

243274:THEMA RS01145
gene id: 243274:THEMA_RS01145
uniprot id: G4FDC0
uniprot id: Q56308
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm
messages: Monomer.

243274:THEMA RS00095
gene id: 243274:THEMA_RS00095
uniprot id: Q9X010
uniprot id: R4NQ08
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

243274:THEMA RS00500
gene id: 243274:THEMA_RS00500
uniprot id: Q9WZT5
uniprot id: R4NPU0
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

243274:THEMA RS06325
gene id: 243274:THEMA_RS06325
uniprot id: Q9X1R2
uniprot id: R4P3K4
names: Similarity
messages: Belongs to the TlyA family.

243274:THEMA RS01945
gene id: 243274:THEMA_RS01945
uniprot id: Q9WZ16
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

243274:THEMA RS01765
gene id: 243274:THEMA_RS01765
uniprot id: G4FDP0
uniprot id: Q9WZ49
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: The isolated ADP-bound cytosolic domain forms a 6-fold symmetric protease disk and a 2-fold symmetric AAA ATPase ring. In the absence of nucleotide the AAA ATPase ring also forms symmetric hexamers.

243274:THEMA RS06965
gene id: 243274:THEMA_RS06965
uniprot id: G4FFI8
uniprot id: Q9X1G4
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

243274:THEMA RS07215
gene id: 243274:THEMA_RS07215
uniprot id: Q9X1C4
uniprot id: R4NRA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS00350
gene id: 243274:THEMA_RS00350
uniprot id: Q9WZW1
uniprot id: R4NZD4
names: Similarity
messages: Belongs to the ribF family.

243274:THEMA RS05890
gene id: 243274:THEMA_RS05890
uniprot id: G4FG46
uniprot id: Q9X1Y7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

243274:THEMA RS06735
gene id: 243274:THEMA_RS06735
uniprot id: G4FFN4
uniprot id: P38510
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

243274:THEMA RS05045
gene id: 243274:THEMA_RS05045
uniprot id: Q9X2E2
uniprot id: R4NU47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

243274:THEMA RS01795
gene id: 243274:THEMA_RS01795
uniprot id: G4FDP5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

243274:THEMA RS07140
gene id: 243274:THEMA_RS07140
uniprot id: G4FFF3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

243274:THEMA RS09575
gene id: 243274:THEMA_RS09575
uniprot id: G4FF51
uniprot id: Q9X037
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

243274:THEMA RS02425
gene id: 243274:THEMA_RS02425
uniprot id: G4FE17
uniprot id: P29397
names: Activity Regulation
names: Domain
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.
messages: Regulated by autoinhibition via interaction of the N-terminal and the C-terminal domains. Autoinhibition may prevent NusG from interacting prematurely with other components of the transcription complex or non-specific interactions with other cellular components.
messages: The N-terminal domain interacts with RNAP and the C-terminal domain binds either to Rho or to RpsJ (NusE). Contains an additional, species-specific domain inserted into the N-terminal domain. The N-terminal and C-terminal domains can interact and form a closed conformation.

243274:THEMA RS05170
gene id: 243274:THEMA_RS05170
uniprot id: G4FGI4
uniprot id: Q9X2B6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Involved in the integration of spacer DNA into the CRISPR cassette (By similarity). Functions as a ssRNA-specific endoribonuclease.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

243274:THEMA RS03915
gene id: 243274:THEMA_RS03915
uniprot id: G4FH83
uniprot id: Q9WY16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

243274:THEMA RS07850
gene id: 243274:THEMA_RS07850
uniprot id: G4FE67
uniprot id: Q9X108
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Binds 1 NAD(+) per subunit.
messages: Homodimer or homotetramer. Exists in a homodimer/homotetramer equilibrium state in solution.
messages: Hydrolyzes cellobiose 6'-phosphate into glucose 6-phosphate (Glc6P) and glucose.
messages: Is a retaining glucosidase as it hydrolyzes glycosidic bond with retention of anomeric configuration. Reaction mechanism includes redox steps involving NAD and stabilization of intermediates by Mn(2+).

243274:THEMA RS07095
gene id: 243274:THEMA_RS07095
uniprot id: G4FFG2
uniprot id: Q9X1E1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
messages: This protein lacks the conserved Gly residues in positions 90 and 93 that are potentially involved in NAD(H) binding. They are replaced by an Asn and an Ala, respectively.

243274:THEMA RS05460
gene id: 243274:THEMA_RS05460
uniprot id: Q9X264
uniprot id: R4P1V1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

243274:THEMA RS04790
gene id: 243274:THEMA_RS04790
uniprot id: Q9X2I1
uniprot id: R4P2F7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the energy-coupling factor EcfT family.
messages: Cell inner membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component, RibU, BioY), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component) upon coexpression in E.coli. A stable subcomplex with both A and T components are also isolated. This complex interacts with at least 2 substrate-specific components, BioY and RibU.
messages: Membrane
messages: Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (Probable). Expression of the complex plus RibU in E.coli allows riboflavin uptake; uptake does not occur in the absence of RibU or the EcfA1A2T complex.

243274:THEMA RS07365
gene id: 243274:THEMA_RS07365
uniprot id: G4FFB2
uniprot id: Q9X196
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

243274:THEMA RS00465
gene id: 243274:THEMA_RS00465
uniprot id: Q9WZU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

243274:THEMA RS02645
gene id: 243274:THEMA_RS02645
uniprot id: G4FHX2
names: Similarity
messages: Belongs to the creatininase superfamily.

243274:THEMA RS04710
gene id: 243274:THEMA_RS04710
uniprot id: Q9WXM5
uniprot id: R4NZA7
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

243274:THEMA RS06010
gene id: 243274:THEMA_RS06010
uniprot id: Q9X1W8
uniprot id: R4NTI8
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

243274:THEMA RS08240
gene id: 243274:THEMA_RS08240
uniprot id: Q9X0S9
uniprot id: R4P2L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS02690
gene id: 243274:THEMA_RS02690
uniprot id: G4FHW3
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

243274:THEMA RS08550
gene id: 243274:THEMA_RS08550
uniprot id: Q9X0M7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell membrane
messages: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.

243274:THEMA RS02545
gene id: 243274:THEMA_RS02545
uniprot id: Q9WYR4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polysaccharide lyase 1 family.
messages: Cleaves unsaturated trigalacturonate from pectin. Activity is highest towards polygalacturonic acid, activity on methylated pectins decreases with an increasing degree of methylation.
messages: Completely inactivated by EGTA.
messages: Homotetramer.
messages: Secreted

243274:THEMA RS00690
gene id: 243274:THEMA_RS00690
uniprot id: Q9WZP9
uniprot id: R4P1G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

243274:THEMA RS00710
gene id: 243274:THEMA_RS00710
uniprot id: G4FD36
uniprot id: Q9WZP5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

243274:THEMA RS00550
gene id: 243274:THEMA_RS00550
uniprot id: Q9WZS6
uniprot id: R4NPT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

243274:THEMA RS04565
gene id: 243274:THEMA_RS04565
uniprot id: G4FGV6
uniprot id: Q9WXP6
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

243274:THEMA RS04440
gene id: 243274:THEMA_RS04440
uniprot id: G4FGX9
uniprot id: Q9WXR9
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
messages: Homotrimer.

243274:THEMA RS05885
gene id: 243274:THEMA_RS05885
uniprot id: G4FG47
uniprot id: Q9X1Y8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

243274:THEMA RS06755
gene id: 243274:THEMA_RS06755
uniprot id: G4FFN0
uniprot id: P38509
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

243274:THEMA RS04410
gene id: 243274:THEMA_RS04410
uniprot id: Q9WXS5
uniprot id: R4NZG5
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

243274:THEMA RS04665
gene id: 243274:THEMA_RS04665
uniprot id: Q56318
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

243274:THEMA RS06490
gene id: 243274:THEMA_RS06490
uniprot id: Q9X1N0
uniprot id: R4NT98
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS00860
gene id: 243274:THEMA_RS00860
uniprot id: Q9WZL7
uniprot id: R4NZ58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

243274:THEMA RS01680
gene id: 243274:THEMA_RS01680
uniprot id: Q9WZ65
uniprot id: R4NP46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS06615
gene id: 243274:THEMA_RS06615
uniprot id: G4FFQ8
uniprot id: Q9X1K9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Is not inhibited by (S)-lysine, in contrast to E.coli DapA.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

243274:THEMA RS04905
gene id: 243274:THEMA_RS04905
uniprot id: G4FGN7
uniprot id: G4XU72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS02880
gene id: 243274:THEMA_RS02880
uniprot id: G4FHS6
uniprot id: P80099
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.

243274:THEMA RS02495
gene id: 243274:THEMA_RS02495
uniprot id: Q9WYS4
names: Similarity
messages: Belongs to the FGGY kinase family.

243274:THEMA RS08820
gene id: 243274:THEMA_RS08820
uniprot id: Q9X0H4
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS02705
gene id: 243274:THEMA_RS02705
uniprot id: G4FHW0
uniprot id: Q9WYN2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

243274:THEMA RS07780
gene id: 243274:THEMA_RS07780
uniprot id: Q9X120
uniprot id: R4NSM8
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS05620
gene id: 243274:THEMA_RS05620
uniprot id: G4FG97
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

243274:THEMA RS04145
gene id: 243274:THEMA_RS04145
uniprot id: Q9WXX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 9 family.
messages: Part of an ATP-driven transport system TM_0123/TM_0124/TM_0125 for a metal. Metal-binding component.
messages: Periplasm

243274:THEMA RS03555
gene id: 243274:THEMA_RS03555
uniprot id: Q9WY72
uniprot id: R4NXP9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

243274:THEMA RS00775
gene id: 243274:THEMA_RS00775
uniprot id: G4FD48
uniprot id: Q9WZN3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

243274:THEMA RS04600
gene id: 243274:THEMA_RS04600
uniprot id: Q9WXN9
uniprot id: R4NMJ0
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

243274:THEMA RS04965
gene id: 243274:THEMA_RS04965
uniprot id: G4FGM5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

243274:THEMA RS01300
gene id: 243274:THEMA_RS01300
uniprot id: Q9WZE1
uniprot id: R4P151
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

243274:THEMA RS00225
gene id: 243274:THEMA_RS00225
uniprot id: Q9WZY4
names: Function
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.
messages: Catalyzes the production of homocysteine from O-acetylhomoserine (OAH) and hydrogen sulfide (H2S), a step in the methionine biosynthesis pathway. Is not able to form cystathionine from O-acetylhomoserine and L-cysteine.

243274:THEMA RS01025
gene id: 243274:THEMA_RS01025
uniprot id: Q9WZI6
uniprot id: R4P1D0
names: Similarity
messages: Belongs to the peptidase U62 family.

243274:THEMA RS06375
gene id: 243274:THEMA_RS06375
uniprot id: G4FFV4
uniprot id: Q9X1Q2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

243274:THEMA RS00305
gene id: 243274:THEMA_RS00305
uniprot id: Q9WZX0
uniprot id: R4P1N2
names: Similarity
messages: Belongs to the band 7/mec-2 family.

243274:THEMA RS05680
gene id: 243274:THEMA_RS05680
uniprot id: Q9X224
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

243274:THEMA RS00160
gene id: 243274:THEMA_RS00160
uniprot id: G4FCT0
uniprot id: Q9WZZ7
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

243274:THEMA RS02890
gene id: 243274:THEMA_RS02890
uniprot id: Q9WYJ7
uniprot id: R4NNF8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

243274:THEMA RS06365
gene id: 243274:THEMA_RS06365
uniprot id: G4FFV6
uniprot id: Q9X1Q4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

243274:THEMA RS07450
gene id: 243274:THEMA_RS07450
uniprot id: G4FF97
uniprot id: P46213
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

243274:THEMA RS02125
gene id: 243274:THEMA_RS02125
uniprot id: Q9WYY1
names: Domain
names: Function
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.
messages: Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair as well as from single-stranded DNA.
messages: The seven N-terminal amino acids are important for maintaining proper protein folding and increase temperature stability of the protein.

243274:THEMA RS00660
gene id: 243274:THEMA_RS00660
uniprot id: Q9WZQ5
uniprot id: R4NZ90
names: Similarity
messages: Belongs to the fabD family.

243274:THEMA RS00185
gene id: 243274:THEMA_RS00185
uniprot id: G4FCT5
uniprot id: Q9WZZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell inner membrane
messages: Membrane

243274:THEMA RS04895
gene id: 243274:THEMA_RS04895
uniprot id: Q08638
names: Caution
names: Similarity
messages: As the DNA coding for this protein is not found in the complete genome of T.maritima. It could have originated from another bacterial species.
messages: Belongs to the glycosyl hydrolase 1 family.

243274:THEMA RS00410
gene id: 243274:THEMA_RS00410
uniprot id: Q9WZV0
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

243274:THEMA RS05575
gene id: 243274:THEMA_RS05575
uniprot id: G4FGA6
uniprot id: P74926
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity).
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

243274:THEMA RS00045
gene id: 243274:THEMA_RS00045
uniprot id: Q9X020
uniprot id: R4NQ16
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

243274:THEMA RS02410
gene id: 243274:THEMA_RS02410
uniprot id: G4FE14
uniprot id: P29394
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors (such as IF-2, EF-Tu, EF-G and RF3).
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and 23S rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which 3 L12 dimers bind in a sequential fashion forming a heptameric L10(L12)2(L12)2(L12)2 complex.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

243274:THEMA RS08360
gene id: 243274:THEMA_RS08360
uniprot id: Q9X0R1
uniprot id: R4NQQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

243274:THEMA RS07105
gene id: 243274:THEMA_RS07105
uniprot id: G4FFG0
uniprot id: Q7DF98
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

243274:THEMA RS01190
gene id: 243274:THEMA_RS01190
uniprot id: G4FDC9
uniprot id: Q9WZF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

243274:THEMA RS01000
gene id: 243274:THEMA_RS01000
uniprot id: G4FD92
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

243274:THEMA RS00390
gene id: 243274:THEMA_RS00390
uniprot id: G4FCX4
uniprot id: Q9WZV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

243274:THEMA RS08130
gene id: 243274:THEMA_RS08130
uniprot id: Q9X0V1
uniprot id: R4NQX8
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

243274:THEMA RS04150
gene id: 243274:THEMA_RS04150
uniprot id: Q9WXX6
uniprot id: R4NPD7
names: Similarity
messages: Belongs to the Fur family.

243274:THEMA RS05195
gene id: 243274:THEMA_RS05195
uniprot id: G4FGH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISPR system Cmr5 family.
messages: Cytoplasm

243274:THEMA RS02245
gene id: 243274:THEMA_RS02245
uniprot id: Q9WYV6
uniprot id: R4P0K3
names: Similarity
messages: Belongs to the UPF0045 family.

243274:THEMA RS08200
gene id: 243274:THEMA_RS08200
uniprot id: Q9X0T7
uniprot id: R4NSD0
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS02985
gene id: 243274:THEMA_RS02985
uniprot id: Q9WYH8
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I DAHP synthase family.
messages: Catalyzes the condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
messages: Divalent metal ions.
messages: Homotetramer.
messages: Inhibited by L-phenylalanine and L-tyrosine.

243274:THEMA RS00120
gene id: 243274:THEMA_RS00120
uniprot id: G4FCS3
uniprot id: Q9X005
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CheD family.
messages: Deamidates glutamine residues on chemoreceptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the CheA kinase. In addition, demethylates methylated glutamate residues on chemoreceptors Mcp2 and Mcp4. Enhances the activity of CheC.
messages: Heterodimer with CheC. The CheC-CheD heterodimer interacts with phosphorylated CheY.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

243274:THEMA RS05750
gene id: 243274:THEMA_RS05750
uniprot id: G4FG71
uniprot id: O54311
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

243274:THEMA RS04980
gene id: 243274:THEMA_RS04980
uniprot id: Q9X2F5
uniprot id: R4P224
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS03920
gene id: 243274:THEMA_RS03920
uniprot id: G4FH82
uniprot id: Q9WY15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

243274:THEMA RS02655
gene id: 243274:THEMA_RS02655
uniprot id: Q9WYP2
uniprot id: R4P0D8
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

243274:THEMA RS05730
gene id: 243274:THEMA_RS05730
uniprot id: G4FG75
uniprot id: Q9X214
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription (By similarity).
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

243274:THEMA RS03415
gene id: 243274:THEMA_RS03415
uniprot id: G4FHH2
uniprot id: P46799
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Binds two Mg(2+) per subunit.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

243274:THEMA RS06355
gene id: 243274:THEMA_RS06355
uniprot id: Q9X1Q6
names: Similarity
messages: To A.aeolicus AQ_054.

243274:THEMA RS09195
gene id: 243274:THEMA_RS09195
uniprot id: G4FEY2
uniprot id: P96110
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

243274:THEMA RS06910
gene id: 243274:THEMA_RS06910
uniprot id: G4FFJ9
uniprot id: P58288
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

243274:THEMA RS09340
gene id: 243274:THEMA_RS09340
uniprot id: Q9X081
names: Similarity
messages: To E.coli YfaT and P.aeruginosa PA4490.

243274:THEMA RS03440
gene id: 243274:THEMA_RS03440
uniprot id: Q9WY95
names: Similarity
messages: Belongs to the UPF0102 family.

243274:THEMA RS03630
gene id: 243274:THEMA_RS03630
uniprot id: Q9WY58
uniprot id: R4NXK7
names: Similarity
messages: Belongs to the RutC family.

243274:THEMA RS02540
gene id: 243274:THEMA_RS02540
uniprot id: Q9WYR5
uniprot id: R4NQ64
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

243274:THEMA RS03245
gene id: 243274:THEMA_RS03245
uniprot id: G4FHK6
uniprot id: Q9WYC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

243274:THEMA RS07905
gene id: 243274:THEMA_RS07905
uniprot id: Q9X0Z7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family.
messages: Catalyzes the racemization of L-alanine to D-alanine, and of L-glutamate to D-glutamate. The activity is low, but likely physiological since T.maritima lacks canonical alr and murI genes, while D-alanine and D-glutamate are essential components of peptidoglycan. Also displays a more efficient cystathionine beta-lyase (CBL) activity, cleaving cystathionine to homocysteine and pyruvate; however, this reaction seems not to be physiologically relevant since T.maritima possesses an O-acetyl-homoserine thiolase (MetY) that bypasses the need of CBL for methionine biosynthesis. Is not able to produce cystathionine, using either O-acetylhomoserine or O-succinylhomoserine, plus L-cysteine as substrates, and thus does not possess cystathionine gamma-synthase (CGS) activity.
messages: Homotetramer; dimer of active dimers.

243274:THEMA RS06570
gene id: 243274:THEMA_RS06570
uniprot id: Q9X1L4
uniprot id: R4NRL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell inner membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

243274:THEMA RS01915
gene id: 243274:THEMA_RS01915
uniprot id: G4FDR9
uniprot id: Q9WZ22
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.

243274:THEMA RS02400
gene id: 243274:THEMA_RS02400
uniprot id: P29398
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

243274:THEMA RS07770
gene id: 243274:THEMA_RS07770
uniprot id: G4FE53
names: Similarity
messages: Belongs to the RNase H family.

243274:THEMA RS06250
gene id: 243274:THEMA_RS06250
uniprot id: Q9X1S5
uniprot id: R4NTE3
names: Similarity
messages: Belongs to the intimin/invasin family.

243274:THEMA RS02075
gene id: 243274:THEMA_RS02075
uniprot id: G4FDV0
uniprot id: Q9WYZ1
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: According to PubMed:12646382 the propeptide is autoprocessed in 20% of the cases in the expression system (E.coli).
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

243274:THEMA RS05330
gene id: 243274:THEMA_RS05330
uniprot id: Q9X287
uniprot id: R4P1X2
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

243274:THEMA RS04135
gene id: 243274:THEMA_RS04135
uniprot id: G4FH40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS05910
gene id: 243274:THEMA_RS05910
uniprot id: Q9S5X9
uniprot id: R4NTL2
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

243274:THEMA RS07360
gene id: 243274:THEMA_RS07360
uniprot id: Q9X197
uniprot id: R4P312
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS03390
gene id: 243274:THEMA_RS03390
uniprot id: G4FHH7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

243274:THEMA RS06425
gene id: 243274:THEMA_RS06425
uniprot id: Q9X1P2
uniprot id: R4P3I2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

243274:THEMA RS00565
gene id: 243274:THEMA_RS00565
uniprot id: Q9WZS4
uniprot id: R4P1I9
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS01370
gene id: 243274:THEMA_RS01370
uniprot id: Q9WZC7
uniprot id: R4NYT3
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

243274:THEMA RS04865
gene id: 243274:THEMA_RS04865
uniprot id: Q9X2G8
uniprot id: R4P2E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS04185
gene id: 243274:THEMA_RS04185
uniprot id: Q9WXX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system.
messages: The complex is composed of an ATP-binding protein (RbsA), two transmembrane proteins (RbsC) and a solute-binding protein (RbsB).

243274:THEMA RS03335
gene id: 243274:THEMA_RS03335
uniprot id: G4FHI8
uniprot id: Q9WYB1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Phosphorylates propionate (54%) in addition to acetate (100%). Uses GTP (100%), ITP (163%), UTP (56%), and CTP (21%) as phosphoryl donors in addition to ATP (100%).
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

243274:THEMA RS09170
gene id: 243274:THEMA_RS09170
uniprot id: G4FEX7
uniprot id: R4P012
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS01265
gene id: 243274:THEMA_RS01265
uniprot id: G4FDE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

243274:THEMA RS05435
gene id: 243274:THEMA_RS05435
uniprot id: G4FGD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS07030
gene id: 243274:THEMA_RS07030
uniprot id: Q9X1F3
uniprot id: R4NRD5
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

243274:THEMA RS02750
gene id: 243274:THEMA_RS02750
uniprot id: Q9WYM4
uniprot id: R4NNI4
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

243274:THEMA RS02920
gene id: 243274:THEMA_RS02920
uniprot id: Q9WYJ1
uniprot id: R4NXZ5
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

243274:THEMA RS08235
gene id: 243274:THEMA_RS08235
uniprot id: Q9X0T0
uniprot id: R4P0A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

243274:THEMA RS09140
gene id: 243274:THEMA_RS09140
uniprot id: Q9X0B6
uniprot id: R4NZT4
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

243274:THEMA RS06510
gene id: 243274:THEMA_RS06510
uniprot id: G4FFS8
uniprot id: Q9X1M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

243274:THEMA RS01985
gene id: 243274:THEMA_RS01985
uniprot id: Q9WZ08
uniprot id: R4NNY1
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS06835
gene id: 243274:THEMA_RS06835
uniprot id: G4FFL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

243274:THEMA RS04730
gene id: 243274:THEMA_RS04730
uniprot id: G4FGS2
uniprot id: Q9WXM1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the epimerization of L-Ala-D-Glu to L-Ala-L-Glu and has probably a role in the metabolism of the murein peptide, of which L-Ala-D-Glu is a component. Is also able to catalyze the reverse reaction and the epimerization of a broad range of other dipeptides; is most efficient with L-Ala-D/L-Phe, L-Ala-D/L-Tyr, and L-Ala-D/L-His.

243274:THEMA RS05155
gene id: 243274:THEMA_RS05155
uniprot id: Q9X2B9
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

243274:THEMA RS01325
gene id: 243274:THEMA_RS01325
uniprot id: Q9WZD6
uniprot id: R4P146
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

243274:THEMA RS03635
gene id: 243274:THEMA_RS03635
uniprot id: G4FHC8
uniprot id: Q9WY57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

243274:THEMA RS01930
gene id: 243274:THEMA_RS01930
uniprot id: Q9WZ19
uniprot id: R4NQH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

243274:THEMA RS00955
gene id: 243274:THEMA_RS00955
uniprot id: G4FD83
uniprot id: Q9WZJ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

243274:THEMA RS03200
gene id: 243274:THEMA_RS03200
uniprot id: Q9WYD7
uniprot id: R4NNB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS07325
gene id: 243274:THEMA_RS07325
uniprot id: G4FFC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

243274:THEMA RS06170
gene id: 243274:THEMA_RS06170
uniprot id: Q9X1T8
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 Ni(2+) ion per monomer; it is not certain this is the physiological metal.
messages: Homodimer.
messages: Probably functions to regulate transcription of NAD metabolic genes. Binds to DNA upstream of the probable nadBII/nadA/nadC and niaRP operons in a nicotinic acid dependent fashion. Nicotinic acid may be a corepressor.

243274:THEMA RS06015
gene id: 243274:THEMA_RS06015
uniprot id: Q9X1W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

243274:THEMA RS02695
gene id: 243274:THEMA_RS02695
uniprot id: Q9WYN4
uniprot id: R4NNJ3
names: Similarity
messages: Belongs to the P(II) protein family.

243274:THEMA RS06105
gene id: 243274:THEMA_RS06105
uniprot id: G4FG03
uniprot id: Q9X1V0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

243274:THEMA RS07245
gene id: 243274:THEMA_RS07245
uniprot id: G4FFD4
uniprot id: Q9X1B8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

243274:THEMA RS08065
gene id: 243274:THEMA_RS08065
uniprot id: Q9X0W5
uniprot id: R4P2S5
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

243274:THEMA RS01635
gene id: 243274:THEMA_RS01635
uniprot id: G4FDL4
uniprot id: Q9WZ74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

243274:THEMA RS04260
gene id: 243274:THEMA_RS04260
uniprot id: G4FH15
uniprot id: Q9WXV5
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

243274:THEMA RS06905
gene id: 243274:THEMA_RS06905
uniprot id: G4FFK0
uniprot id: Q9X1H5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine-5'-phosphate glycosidase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil.
messages: Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
messages: Homotrimer.

243274:THEMA RS08865
gene id: 243274:THEMA_RS08865
uniprot id: G4FER7
uniprot id: Q9X0H0
names: Function
names: PTM
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.
messages: In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts an anti-sigma factor and thus releases a sigma factor from inhibition.
messages: Phosphorylated on a serine residue.

243274:THEMA RS00545
gene id: 243274:THEMA_RS00545
uniprot id: Q9WZS7
uniprot id: R4NRB3
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

243274:THEMA RS00595
gene id: 243274:THEMA_RS00595
uniprot id: Q9WZR8
uniprot id: R4NZJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS08145
gene id: 243274:THEMA_RS08145
uniprot id: Q9X0U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS03410
gene id: 243274:THEMA_RS03410
uniprot id: P46805
uniprot id: R4P006
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

243274:THEMA RS06130
gene id: 243274:THEMA_RS06130
uniprot id: G4FFZ8
uniprot id: O50550
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

243274:THEMA RS03385
gene id: 243274:THEMA_RS03385
uniprot id: Q9WYA2
uniprot id: R4P009
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

243274:THEMA RS00725
gene id: 243274:THEMA_RS00725
uniprot id: G4FD39
uniprot id: Q9WZP2
names: Activity Regulation
names: Biotechnology
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A flavin ligand is bound near the 3-fold axis channel; FMN is consistent with the observed density, absorbance data and mass spectrometry.
messages: Belongs to the encapsulin family. Family 1 subfamily.
messages: Encapsulin nanocompartment
messages: Foreign proteins can be targeted to ectopic nanocompartments in E.coli upon coexpression with a construct using the 15 C-terminal residues of Flp (AC Q9WZP3), tested with GFP. There are at most 20 GFP per compartment. Empty nanocompartments can be disassembled by extreme pH or by 7 M guanidine hydrochloride (GuHCl); only reassembly from GuHCl-dissociated compartments allows incorporation of targeted cargo (PubMed:27224728). The central pore in the pentamer can be enlarged by modifying the pore-forming loop (residues 184-189), which allows transport of larger metabolites than wild-type pores (PubMed:30376298). Artificial metabolons made by targeting proteins to the outside and inside of the nanocompartment have also been made in E.coli; increasing pore size increases metabolic flux (PubMed:33769792). Foreign proteins targeted to nanocompartments have been purified and characterized from insect cells. By C-terminally tagging only IDM1 of A.thaliana, all 6 components of the IDM complex were targeted to the nanocompartment (PubMed:32961724).
messages: Has 3 domains; a discontinuous peripheral domain (P, 13-39, 76-133, 221-254), an elongated loop (E, 53-73) and the discontinuous axial domain (A, 137-216 and 259-263). The E-loop forms contacts between two subunits, while the A domain mediates contacts in the 5-fold interface (PubMed:19172747). Pores are formed by residues 184-189, pore size can be modified by mutagenesis (PubMed:30376298, PubMed:33769792).
messages: Homomultimeric (PubMed:9872409). This encapsulin nanocompartment is formed by 60 subunits; monomers form 12 pentamers which assemble to form shells. There are 12 pores where the pentamers meet as well as 3-fold axis channels and dimer channels; none are larger than 3-4 Angstroms in diameter. The N-terminus of the protein is inside the shell, the C-terminus is outside.
messages: Protease that exhibits activity toward chymotrypsin and trypsin substrates (PubMed:9872409, PubMed:11210524). Probably does not have antibacterial activity (Probable).
messages: Proteolysis activated by calcium and cobalt.
messages: Shell component of a type 1 encapsulin nanocompartment. Assembles into proteinaceous shells 23-24 nm in diameter with 2-2.5 nm thick walls. Cargo protein Flp (ferritin-like protein, may store iron) is targeted to the interior via its C-terminal extension; empty intact shells can be isolated in the absence of cargo protein (PubMed:19172747, PubMed:27224728, PubMed:32961724, PubMed:30376298, PubMed:33769792, PubMed:33953921, PubMed:34815415). Fe(2+) may be able to pass though the 5-fold and dimer channels in the protein shell (Probable).
messages: Shows substantial structural similarity to gp5 of the HK97 viral capsid; while the sequence homology is weak, it suggests this protein may have evolved from a viral capsid protein.

243274:THEMA RS02115
gene id: 243274:THEMA_RS02115
uniprot id: Q9WYY3
uniprot id: R4NYD0
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

243274:THEMA RS01195
gene id: 243274:THEMA_RS01195
uniprot id: G4FDD0
uniprot id: Q9WZF8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

243274:THEMA RS05480
gene id: 243274:THEMA_RS05480
uniprot id: Q9X260
uniprot id: R4NSB7
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS06705
gene id: 243274:THEMA_RS06705
uniprot id: G4FFP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

243274:THEMA RS00420
gene id: 243274:THEMA_RS00420
uniprot id: G4FCY0
uniprot id: Q9WZU8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

243274:THEMA RS01010
gene id: 243274:THEMA_RS01010
uniprot id: G4FD94
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

243274:THEMA RS07580
gene id: 243274:THEMA_RS07580
uniprot id: Q9X158
uniprot id: R4P2Y7
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS00665
gene id: 243274:THEMA_RS00665
uniprot id: G4FD27
uniprot id: Q9WZQ4
names: Similarity
messages: Belongs to the ComB family.

243274:THEMA RS01645
gene id: 243274:THEMA_RS01645
uniprot id: G4FDL6
uniprot id: Q9WZ72
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

243274:THEMA RS06925
gene id: 243274:THEMA_RS06925
uniprot id: Q9X1H2
uniprot id: R4NT21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

243274:THEMA RS01805
gene id: 243274:THEMA_RS01805
uniprot id: G4FDP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

243274:THEMA RS04215
gene id: 243274:THEMA_RS04215
uniprot id: G4FH24
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

243274:THEMA RS02295
gene id: 243274:THEMA_RS02295
uniprot id: G4FDZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

243274:THEMA RS02365
gene id: 243274:THEMA_RS02365
uniprot id: G4FE04
uniprot id: Q9WYT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

243274:THEMA RS04275
gene id: 243274:THEMA_RS04275
uniprot id: Q9WXV2
uniprot id: R4NMP9
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

243274:THEMA RS03160
gene id: 243274:THEMA_RS03160
uniprot id: G4FHM3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

243274:THEMA RS06880
gene id: 243274:THEMA_RS06880
uniprot id: Q9X1H9
names: Function
names: Subunit
messages: Binds long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
messages: Monomer.

243274:THEMA RS01045
gene id: 243274:THEMA_RS01045
uniprot id: Q9WZI2
uniprot id: R4NZ23
names: Similarity
messages: Belongs to the UPF0047 family.

243274:THEMA RS06845
gene id: 243274:THEMA_RS06845
uniprot id: G4FFL2
uniprot id: Q9X1I5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

243274:THEMA RS03955
gene id: 243274:THEMA_RS03955
uniprot id: Q9WY08
uniprot id: R4NMX3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

243274:THEMA RS05625
gene id: 243274:THEMA_RS05625
uniprot id: G4FG96
uniprot id: Q9X235
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

243274:THEMA RS00270
gene id: 243274:THEMA_RS00270
uniprot id: G4FCV2
names: Similarity
messages: Belongs to the ClpA/ClpB family.

243274:THEMA RS01250
gene id: 243274:THEMA_RS01250
uniprot id: Q9WZE9
uniprot id: R4P162
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS04290
gene id: 243274:THEMA_RS04290
uniprot id: Q9WXU9
uniprot id: R4NXJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

243274:THEMA RS00655
gene id: 243274:THEMA_RS00655
uniprot id: Q9WZQ6
uniprot id: R4NPR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BioY family.
messages: Cell inner membrane
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component, RibU, BioY), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component) upon coexpression in E.coli. A stable subcomplex with both A and T components are also isolated. This complex interacts with at least 2 substrate-specific components, BioY and RibU.
messages: Substrate-binding (S) component of an energy-coupling factor (ECF) ABC-transporter complex. Probably a biotin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins (Probable).

243274:THEMA RS00330
gene id: 243274:THEMA_RS00330
uniprot id: Q9WZW5
uniprot id: R4P1M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

243274:THEMA RS00170
gene id: 243274:THEMA_RS00170
uniprot id: G4FCT2
uniprot id: Q9WZZ5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

243274:THEMA RS02990
gene id: 243274:THEMA_RS02990
uniprot id: Q9WYH7
uniprot id: R4NNE2
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS07985
gene id: 243274:THEMA_RS07985
uniprot id: Q9X0Y1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Displays high phosphatase activity toward erythrose 4-phosphate, fructose 6-phosphate, 2-deoxyglucose 6-phosphate, and mannose 6-phosphate. May have a role in the intracellular metabolism of many phosphorylated carbohydrates.
messages: Divalent metal cation. Highest activity with Co(2+), followed by Mg(2+), Mn(2+) or Ni(2+).

243274:THEMA RS08835
gene id: 243274:THEMA_RS08835
uniprot id: Q9X0H3
uniprot id: R4NQG5
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS04755
gene id: 243274:THEMA_RS04755
uniprot id: G4FGR7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

243274:THEMA RS04615
gene id: 243274:THEMA_RS04615
uniprot id: Q9WXN6
uniprot id: R4NXC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS04870
gene id: 243274:THEMA_RS04870
uniprot id: Q9X2G7
uniprot id: R4NU81
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

243274:THEMA RS07735
gene id: 243274:THEMA_RS07735
uniprot id: G4FE45
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS06865
gene id: 243274:THEMA_RS06865
uniprot id: G4FFK8
uniprot id: Q9X1I1
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

243274:THEMA RS05070
gene id: 243274:THEMA_RS05070
uniprot id: G4FGK4
uniprot id: Q9X2D7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

243274:THEMA RS09490
gene id: 243274:THEMA_RS09490
uniprot id: Q9X050
uniprot id: R4NZV2
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS00415
gene id: 243274:THEMA_RS00415
uniprot id: Q9WZU9
uniprot id: R4NZL9
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS05585
gene id: 243274:THEMA_RS05585
uniprot id: Q9X242
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

243274:THEMA RS06360
gene id: 243274:THEMA_RS06360
uniprot id: Q9X1Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

243274:THEMA RS00840
gene id: 243274:THEMA_RS00840
uniprot id: G4FD61
uniprot id: Q9WZM1
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

243274:THEMA RS02140
gene id: 243274:THEMA_RS02140
uniprot id: Q9WYX8
names: Similarity
messages: In the N-terminal section; belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

243274:THEMA RS03690
gene id: 243274:THEMA_RS03690
uniprot id: Q9WY46
uniprot id: R4NXV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS01900
gene id: 243274:THEMA_RS01900
uniprot id: Q9WZ25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

243274:THEMA RS08615
gene id: 243274:THEMA_RS08615
uniprot id: G4FEL8
uniprot id: Q9X0L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: Cytoplasm
messages: Homotetramer.
messages: In addition to acetyl-CoA (100%), the enzyme accepts propionyl-CoA (60%) and butyryl-CoA (30%).

243274:THEMA RS04805
gene id: 243274:THEMA_RS04805
uniprot id: G4FGQ7
uniprot id: Q9X2H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. In vitro, can also cleave single-stranded substrates with inosine, double-stranded DNA with apurinic sites, or DNA sites with uracil or a mismatched base. When present in molar excess, two protein molecules can bind to the same DNA substrate and effect cleavage of both strands (in vitro).

243274:THEMA RS03545
gene id: 243274:THEMA_RS03545
uniprot id: G4FHE6
uniprot id: Q9WY74
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS08125
gene id: 243274:THEMA_RS08125
uniprot id: Q9X0V2
uniprot id: R4NSH8
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

243274:THEMA RS02800
gene id: 243274:THEMA_RS02800
uniprot id: Q9WYL2
uniprot id: R4NY14
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

243274:THEMA RS09075
gene id: 243274:THEMA_RS09075
uniprot id: G4FEV9
uniprot id: Q9X0C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

243274:THEMA RS02905
gene id: 243274:THEMA_RS02905
uniprot id: Q9WYJ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MDIP synthase family.
messages: Catalyzes the transfer of the mannosyl group from GDP-mannose to di-myo-inositol-1,3'-phosphate (DIP), producing mannosyl-di-myo-inositol phosphate (MDIP). Can also use MDIP as an acceptor of a second mannose residue, yielding di-mannosyl-di-myo-inositol phosphate (MMDIP). Minor amounts of the tri-mannosylated form are also formed.
messages: Mg(2+) is required for maximal activity.

243274:THEMA RS01815
gene id: 243274:THEMA_RS01815
uniprot id: Q9WZ41
uniprot id: R4NYI7
names: Similarity
messages: Belongs to the peptidase S1C family.

243274:THEMA RS09110
gene id: 243274:THEMA_RS09110
uniprot id: G4FEW6
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS06550
gene id: 243274:THEMA_RS06550
uniprot id: Q9X1L8
uniprot id: R4P168
names: Similarity
messages: Belongs to the ETF-QO/FixC family.

243274:THEMA RS00340
gene id: 243274:THEMA_RS00340
uniprot id: G4FCW5
uniprot id: Q9WZW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

243274:THEMA RS09590
gene id: 243274:THEMA_RS09590
uniprot id: G4FF54
uniprot id: Q9X034
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine. Adenosine-5-monophosphate (AMP) and S-adenosyl-L-methionine (SAM) are not enzyme substrates.

243274:THEMA RS06915
gene id: 243274:THEMA_RS06915
uniprot id: G4FFJ8
uniprot id: Q9X1H4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

243274:THEMA RS05250
gene id: 243274:THEMA_RS05250
uniprot id: G4FGG9
uniprot id: Q9X2A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

243274:THEMA RS04825
gene id: 243274:THEMA_RS04825
uniprot id: G4FGQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

243274:THEMA RS07510
gene id: 243274:THEMA_RS07510
uniprot id: G4FF85
uniprot id: Q9X170
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS06345
gene id: 243274:THEMA_RS06345
uniprot id: Q9X1Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

243274:THEMA RS01160
gene id: 243274:THEMA_RS01160
uniprot id: Q56311
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors.

243274:THEMA RS04700
gene id: 243274:THEMA_RS04700
uniprot id: G4FGS8
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

243274:THEMA RS07235
gene id: 243274:THEMA_RS07235
uniprot id: Q9X1C0
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Involved in the degradation of L-serine via 3-hydroxypyruvate. Catalyzes the transamination between L-serine and pyruvate to yield 3-hydroxypyruvate and alanine.

243274:THEMA RS04400
gene id: 243274:THEMA_RS04400
uniprot id: Q9WXS7
uniprot id: R4NMM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS04760
gene id: 243274:THEMA_RS04760
uniprot id: Q9X2I7
uniprot id: R4P4E9
names: Subcellular Location Annotation
messages: Cytoplasm

243274:THEMA RS05840
gene id: 243274:THEMA_RS05840
uniprot id: G4FG56
uniprot id: Q9X1Z5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

243274:THEMA RS03370
gene id: 243274:THEMA_RS03370
uniprot id: G4FHI1
uniprot id: Q9WYA4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS08195
gene id: 243274:THEMA_RS08195
uniprot id: Q9X0T8
uniprot id: R4P0L6
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS09050
gene id: 243274:THEMA_RS09050
uniprot id: G4FEV4
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

243274:THEMA RS08720
gene id: 243274:THEMA_RS08720
uniprot id: G4FEN9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

243274:THEMA RS08205
gene id: 243274:THEMA_RS08205
uniprot id: Q9X0T6
uniprot id: R4NQT6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

243274:THEMA RS06195
gene id: 243274:THEMA_RS06195
uniprot id: Q9X1T3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of D-lysine and L-lysine. Has also high activity toward ornithine, and weaker activity toward alanine. Contributes to production of D-lysine and D-alanine for use as peptidoglycan components.
messages: Homodimer.

243274:THEMA RS01155
gene id: 243274:THEMA_RS01155
uniprot id: Q56310
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY (By similarity).

243274:THEMA RS06645
gene id: 243274:THEMA_RS06645
uniprot id: Q9X1K3
uniprot id: R4P1D6
names: Similarity
messages: Belongs to the Fur family.

243274:THEMA RS03485
gene id: 243274:THEMA_RS03485
uniprot id: G4FHF8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

243274:THEMA RS01395
gene id: 243274:THEMA_RS01395
uniprot id: G4FDH0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS03600
gene id: 243274:THEMA_RS03600
uniprot id: Q9WY64
uniprot id: R4NN39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

243274:THEMA RS07525
gene id: 243274:THEMA_RS07525
uniprot id: Q9X167
uniprot id: R4P100
names: Similarity
messages: Belongs to the peptidase M16 family.

243274:THEMA RS00950
gene id: 243274:THEMA_RS00950
uniprot id: G4FD82
uniprot id: Q9WZK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

243274:THEMA RS01105
gene id: 243274:THEMA_RS01105
uniprot id: Q9WZH1
uniprot id: R4NZ85
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS07425
gene id: 243274:THEMA_RS07425
uniprot id: G4FFA2
uniprot id: Q9X186
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

243274:THEMA RS02070
gene id: 243274:THEMA_RS02070
uniprot id: G4FDU9
uniprot id: Q9WYZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP (By similarity).
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

243274:THEMA RS01040
gene id: 243274:THEMA_RS01040
uniprot id: Q9WZI3
uniprot id: R4NPL1
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS00720
gene id: 243274:THEMA_RS00720
uniprot id: Q9WZP3
names: Biotechnology
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ferritin-like superfamily.
messages: Cargo protein of a type 1 encapsulin nanocompartment. A ferritin-like protein that probably stores iron in the encapsulin nanocompartment.
messages: Encapsulin nanocompartment
messages: Probably forms a decamer which binds to the pentameric axis of the interior of the protein shell; as the Flp cargo protein is flexible, packing into the shell is not rigid.
messages: The 15 or 30 C-terminal residues can be used to target foreign proteins to the nanocompartment.
messages: The C-terminal 15-30 residues (cargo loading-peptide, CLP, or targeting peptide) are sufficient to target this protein to the nanocompartment in vivo, while the C-terminal 5 residues suffice in vitro.

243274:THEMA RS03790
gene id: 243274:THEMA_RS03790
uniprot id: Q9WY31
uniprot id: R4NXT8
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

243274:THEMA RS06810
gene id: 243274:THEMA_RS06810
uniprot id: G4FFL9
uniprot id: Q9X1J1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

243274:THEMA RS01940
gene id: 243274:THEMA_RS01940
uniprot id: G4FDS4
names: Similarity
messages: Belongs to the aspartokinase family.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

243274:THEMA RS06775
gene id: 243274:THEMA_RS06775
uniprot id: G4FFM6
uniprot id: P38513
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

243274:THEMA RS02975
gene id: 243274:THEMA_RS02975
uniprot id: G4FHQ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

243274:THEMA RS04570
gene id: 243274:THEMA_RS04570
uniprot id: Q9WXP5
uniprot id: R4NP53
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

243274:THEMA RS08530
gene id: 243274:THEMA_RS08530
uniprot id: G4FEK1
uniprot id: Q9X0N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell membrane
messages: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.

243274:THEMA RS08650
gene id: 243274:THEMA_RS08650
uniprot id: G4FEM5
uniprot id: Q9X0K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity).
messages: Secreted

243274:THEMA RS03605
gene id: 243274:THEMA_RS03605
uniprot id: G4FHD4
uniprot id: Q9WY63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: Homodimer in the absence of FliF. Interacts (via N-terminus) with FliF (via C-terminus) forming a heterodimer. Interacts (via central domain or via central domain and C-terminus) with FliM (via central domain).
messages: Membrane
messages: One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).
messages: One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation.

243274:THEMA RS09730
gene id: 243274:THEMA_RS09730
uniprot id: Q9X1N1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF nuclease family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

243274:THEMA RS02300
gene id: 243274:THEMA_RS02300
uniprot id: G4FDZ2
uniprot id: Q9WYU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

243274:THEMA RS01090
gene id: 243274:THEMA_RS01090
uniprot id: Q9WZH4
uniprot id: R4NPI1
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

243274:THEMA RS02010
gene id: 243274:THEMA_RS02010
uniprot id: Q9WZ03
uniprot id: R4NNX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS06885
gene id: 243274:THEMA_RS06885
uniprot id: P58010
names: Subcellular Location Annotation
messages: Cell membrane

243274:THEMA RS06420
gene id: 243274:THEMA_RS06420
uniprot id: Q9X1P3
names: Similarity
messages: Belongs to the UPF0758 family.

243274:THEMA RS02615
gene id: 243274:THEMA_RS02615
uniprot id: Q9WYQ0
uniprot id: R4NQ53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS08210
gene id: 243274:THEMA_RS08210
uniprot id: G4FED8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

243274:THEMA RS08285
gene id: 243274:THEMA_RS08285
uniprot id: G4FEF3
uniprot id: Q56307
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

243274:THEMA RS02560
gene id: 243274:THEMA_RS02560
uniprot id: Q9WYR1
uniprot id: R4NYF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS04990
gene id: 243274:THEMA_RS04990
uniprot id: O33830
uniprot id: R4P2C3
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Alpha-glycosidase with a very broad specificity. Hydrolyzes maltose and other small maltooligosaccharides but is inactive against the polymeric substrate starch. AglA is not specific with respect to the configuration at the C-4 position of its substrates because glycosidic derivatives of D-galactose are also hydrolyzed. Does not cleave beta-glycosidic bonds.
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 Mn(2+) ion per subunit. Can also use Co(2+) and Ni(2+) ions, albeit less efficiently than manganese ion.
messages: Binds 1 NAD(+) per subunit.
messages: Homodimer.
messages: In the crystal structure (PubMed:12588867), the metal ion is absent, probably due to the oxidation of the active site Cys-174 to sulfinic acid. In the absence of metal, positions of the coenzyme and the substrate and their interactions are all significantly altered, presumably accounting for the inactivity of this form.
messages: Inhibited by Hg(2+) ion and EDTA.

243274:THEMA RS00025
gene id: 243274:THEMA_RS00025
uniprot id: R4NZJ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

243274:THEMA RS05270
gene id: 243274:THEMA_RS05270
uniprot id: G4FGG5
uniprot id: Q9X299
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

243274:THEMA RS02930
gene id: 243274:THEMA_RS02930
uniprot id: Q9WYI9
uniprot id: R4NYA5
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

243274:THEMA RS04240
gene id: 243274:THEMA_RS04240
uniprot id: Q9WXV9
uniprot id: R4NXK0
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS08870
gene id: 243274:THEMA_RS08870
uniprot id: Q9X0G9
uniprot id: R4P285
names: Similarity
messages: Belongs to the LacAB/RpiB family.

243274:THEMA RS00530
gene id: 243274:THEMA_RS00530
uniprot id: G4FD02
uniprot id: Q9WZS9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

243274:THEMA RS08085
gene id: 243274:THEMA_RS08085
uniprot id: Q9X0W0
uniprot id: R4P0G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS05485
gene id: 243274:THEMA_RS05485
uniprot id: G4FGC3
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

243274:THEMA RS02120
gene id: 243274:THEMA_RS02120
uniprot id: Q9WYY2
uniprot id: R4P0N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS05165
gene id: 243274:THEMA_RS05165
uniprot id: Q9X2B7
uniprot id: R4NU25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer (Probable). Forms a heterotetramer with a Cas2 homodimer (By similarity).
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

243274:THEMA RS07160
gene id: 243274:THEMA_RS07160
uniprot id: O33832
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the inositol monophosphatase superfamily. FBPase class 4 family.
messages: Homotetramer.
messages: In contrast to mammalian I-1-P phosphatases, is only weakly inhibited by Li(+), since 50% inhibitory concentration for Li(+) is about 100 mM, and the Li(+) concentration required to totally abolish I-1-Pase activity is 1 M.
messages: Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, both D and L isomers of inositol-1-phosphate (I-1-P) but displaying a 20-fold higher rate of hydrolysis of D-I-1-P than of the L isomer, 2'-AMP, pNPP, inositol-2-phosphate, beta-glycerol phosphate, and alpha-D-glucose-1-phosphate. Cannot hydrolyze glucose-6-phosphate, fructose-6-phosphate, 5'-AMP and NAD(+). May be involved in the biosynthesis of a unique osmolyte, di-myo-inositol 1,1-phosphate.

243274:THEMA RS09360
gene id: 243274:THEMA_RS09360
uniprot id: Q9X077
uniprot id: R4NQ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

243274:THEMA RS00460
gene id: 243274:THEMA_RS00460
uniprot id: G4FCY8
uniprot id: O08398
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins (By similarity). Interacts with FtsA (PubMed:22473211).
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

243274:THEMA RS07950
gene id: 243274:THEMA_RS07950
uniprot id: Q9X0Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

243274:THEMA RS06165
gene id: 243274:THEMA_RS06165
uniprot id: Q9X1T9
uniprot id: R4NRU6
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS02770
gene id: 243274:THEMA_RS02770
uniprot id: Q9WYL8
uniprot id: R4NNI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS06875
gene id: 243274:THEMA_RS06875
uniprot id: G4FFK6
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

243274:THEMA RS06610
gene id: 243274:THEMA_RS06610
uniprot id: Q9X1L0
uniprot id: R4P159
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (PubMed:30548096). Also catalyzes the racemization of certain amino acids, including Lys, with low efficiency (PubMed:30548096).
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably forms homotrimers.

243274:THEMA RS09095
gene id: 243274:THEMA_RS09095
uniprot id: G4FEW3
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

243274:THEMA RS06110
gene id: 243274:THEMA_RS06110
uniprot id: G4FG02
uniprot id: Q9X1U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

243274:THEMA RS00485
gene id: 243274:THEMA_RS00485
uniprot id: G4FCZ3
uniprot id: P74921
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

243274:THEMA RS08990
gene id: 243274:THEMA_RS08990
uniprot id: G4FEU2
uniprot id: Q9X0E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CutA family.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in resistance toward heavy metals.

243274:THEMA RS08030
gene id: 243274:THEMA_RS08030
uniprot id: G4FEA3
uniprot id: Q9X0X2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

243274:THEMA RS02830
gene id: 243274:THEMA_RS02830
uniprot id: Q9WYK7
uniprot id: R4NYB8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

243274:THEMA RS05310
gene id: 243274:THEMA_RS05310
uniprot id: G4FGF7
uniprot id: Q9X291
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

243274:THEMA RS09100
gene id: 243274:THEMA_RS09100
uniprot id: G4FEW4
uniprot id: Q9X0C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
messages: Cytoplasm

243274:THEMA RS06975
gene id: 243274:THEMA_RS06975
uniprot id: G4FFI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

243274:THEMA RS05100
gene id: 243274:THEMA_RS05100
uniprot id: Q9X2D0
uniprot id: R4NSG9
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

243274:THEMA RS04635
gene id: 243274:THEMA_RS04635
uniprot id: Q9WXN2
uniprot id: R4NZC1
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

243274:THEMA RS02420
gene id: 243274:THEMA_RS02420
uniprot id: G4FE16
uniprot id: P29395
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which 3 L12 dimers bind in a sequential fashion forming a heptameric L10(L12)2(L12)2(L12)2 complex.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

243274:THEMA RS04235
gene id: 243274:THEMA_RS04235
uniprot id: Q9WXW0
uniprot id: R4NZK2
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS09085
gene id: 243274:THEMA_RS09085
uniprot id: G4FEW1
uniprot id: Q9X0C7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Monomer.

243274:THEMA RS03175
gene id: 243274:THEMA_RS03175
uniprot id: G4FHM0
names: Function
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

243274:THEMA RS01725
gene id: 243274:THEMA_RS01725
uniprot id: Q9WZ57
uniprot id: R4NQM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

243274:THEMA RS04795
gene id: 243274:THEMA_RS04795
uniprot id: G4FGQ9
uniprot id: P16115
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP). Inactivated by Mn(2+), Co(2+), Cd(2+) and Zn(2+).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Catalyzes the conversion of lactate to pyruvate. It is stereospecific for L(+)-lactate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS08875
gene id: 243274:THEMA_RS08875
uniprot id: G4FER9
uniprot id: Q9X0G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

243274:THEMA RS04420
gene id: 243274:THEMA_RS04420
uniprot id: Q9WXS3
names: Function
names: Similarity
messages: Belongs to the mannitol dehydrogenase family. UxuB subfamily.
messages: Catalyzes the reduction of D-fructuronate (D-FruA) to D-mannonate (D-ManA).

243274:THEMA RS09485
gene id: 243274:THEMA_RS09485
uniprot id: Q9X051
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system.
messages: The complex is composed of an ATP-binding protein (RbsA), two transmembrane proteins (RbsC) and a solute-binding protein (RbsB).

243274:THEMA RS04655
gene id: 243274:THEMA_RS04655
uniprot id: G4FGT7
uniprot id: Q9WXM9
names: Similarity
messages: Belongs to the UPF0166 family.

243274:THEMA RS09735
gene id: 243274:THEMA_RS09735
uniprot id: Q9S5X8
names: Similarity
messages: Belongs to the glycosyl hydrolase 12 (cellulase H) family.

243274:THEMA RS00320
gene id: 243274:THEMA_RS00320
uniprot id: G4FCW1
uniprot id: Q9WZW7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

243274:THEMA RS04465
gene id: 243274:THEMA_RS04465
uniprot id: Q9WXR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS02960
gene id: 243274:THEMA_RS02960
uniprot id: G4FHR0
uniprot id: Q9WYI3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: In the N-terminal section; belongs to the shikimate kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

243274:THEMA RS08980
gene id: 243274:THEMA_RS08980
uniprot id: G4FEU0
names: Similarity
messages: Belongs to the glutamate synthase family.

243274:THEMA RS01120
gene id: 243274:THEMA_RS01120
uniprot id: G4FDB5
uniprot id: Q9WZG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

243274:THEMA RS05390
gene id: 243274:THEMA_RS05390
uniprot id: G4FGE2
uniprot id: Q9X278
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family.
messages: Cytoplasm

243274:THEMA RS06390
gene id: 243274:THEMA_RS06390
uniprot id: Q9X1P9
uniprot id: R4NRQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

243274:THEMA RS09005
gene id: 243274:THEMA_RS09005
uniprot id: Q9X0E3
uniprot id: R4NRW6
names: Similarity
messages: Belongs to the Skp family.

243274:THEMA RS00740
gene id: 243274:THEMA_RS00740
uniprot id: Q9WZN9
uniprot id: R4P1G4
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

243274:THEMA RS01055
gene id: 243274:THEMA_RS01055
uniprot id: G4FDA2
uniprot id: Q9WZI0
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

243274:THEMA RS07640
gene id: 243274:THEMA_RS07640
uniprot id: Q9X147
uniprot id: R4P0N2
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.
messages: Belongs to the radical SAM superfamily. NifB family.

243274:THEMA RS05870
gene id: 243274:THEMA_RS05870
uniprot id: G4FG50
uniprot id: P96113
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

243274:THEMA RS03380
gene id: 243274:THEMA_RS03380
uniprot id: G4FHH9
uniprot id: Q9WYA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

243274:THEMA RS07910
gene id: 243274:THEMA_RS07910
uniprot id: Q9X0Z6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. HydE family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Monomer.
messages: Required for the maturation of the [FeFe]-hydrogenase HydA (By similarity). Catalyzes the reductive cleavage of S-adenosyl-L-methionine (in vitro), suggesting it may contribute to the biosynthesis of an essential sulfur-containing ligand that binds to the hydrogenase active site [2Fe-2S] cluster (PubMed:16137685).

243274:THEMA RS02235
gene id: 243274:THEMA_RS02235
uniprot id: Q9WYV8
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
messages: Monomer and homodimer.
messages: The crystal structure corresponding to PDB 1SG9 shows a glutamate anhydride cross-link formed between the Glu-97 side chains from two molecules, but this has not been observed in other PrmC structures from T.maritima. This cross-link is suggested being an artifact of concentration during crystallization (PubMed:18247349).

243274:THEMA RS01965
gene id: 243274:THEMA_RS01965
uniprot id: Q9WZ12
uniprot id: R4NYF6
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

243274:THEMA RS08855
gene id: 243274:THEMA_RS08855
uniprot id: G4FER5
uniprot id: Q9X0H1
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity). May also act as a chaperone or modulator of proteins involved in DNA or RNA processing.
messages: Belongs to the archease family.

243274:THEMA RS06800
gene id: 243274:THEMA_RS06800
uniprot id: G4FFM1
uniprot id: Q9ZAE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

243274:THEMA RS04525
gene id: 243274:THEMA_RS04525
uniprot id: Q9WXQ4
uniprot id: R4NMK5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

243274:THEMA RS00360
gene id: 243274:THEMA_RS00360
uniprot id: G4FCW9
uniprot id: Q9WZV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer (Ref.3). Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

243274:THEMA RS00630
gene id: 243274:THEMA_RS00630
uniprot id: G4FD20
uniprot id: Q9WZR1
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

243274:THEMA RS07470
gene id: 243274:THEMA_RS07470
uniprot id: Q9X178
uniprot id: R4P300
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

243274:THEMA RS07130
gene id: 243274:THEMA_RS07130
uniprot id: Q9X1D6
uniprot id: R4NRB5
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

243274:THEMA RS03505
gene id: 243274:THEMA_RS03505
uniprot id: G4FHF4
uniprot id: Q9WY82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

243274:THEMA RS07395
gene id: 243274:THEMA_RS07395
uniprot id: G4FFA7
uniprot id: Q9X191
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

243274:THEMA RS08620
gene id: 243274:THEMA_RS08620
uniprot id: Q9X0L3
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
messages: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.

243274:THEMA RS00875
gene id: 243274:THEMA_RS00875
uniprot id: Q9WZL4
uniprot id: R4NR63
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

243274:THEMA RS02965
gene id: 243274:THEMA_RS02965
uniprot id: G4FHQ9
uniprot id: Q9WYI2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

243274:THEMA RS00475
gene id: 243274:THEMA_RS00475
uniprot id: G4FCZ1
uniprot id: P77993
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

243274:THEMA RS05980
gene id: 243274:THEMA_RS05980
uniprot id: G4FG28
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

243274:THEMA RS04740
gene id: 243274:THEMA_RS04740
uniprot id: Q9X2J1
uniprot id: R4P2G4
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

243274:THEMA RS03255
gene id: 243274:THEMA_RS03255
uniprot id: Q9WYC6
uniprot id: R4NXU6
names: Similarity
messages: Belongs to the citrate synthase family.

243274:THEMA RS09460
gene id: 243274:THEMA_RS09460
uniprot id: G4FF29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

243274:THEMA RS05340
gene id: 243274:THEMA_RS05340
uniprot id: Q9X285
uniprot id: R4P266
names: Similarity
messages: Belongs to the asp23 family.

243274:THEMA RS09285
gene id: 243274:THEMA_RS09285
uniprot id: G4FEZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS05510
gene id: 243274:THEMA_RS05510
uniprot id: Q9X254
uniprot id: R4P1U3
names: Similarity
messages: Belongs to the YggT family.

243274:THEMA RS01355
gene id: 243274:THEMA_RS01355
uniprot id: G4FDG2
uniprot id: Q9WZD0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

243274:THEMA RS04010
gene id: 243274:THEMA_RS04010
uniprot id: G4FH64
uniprot id: Q9WXZ7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

243274:THEMA RS04780
gene id: 243274:THEMA_RS04780
uniprot id: Q9X2I3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings (By similarity).
messages: Belongs to the ParA family. MinD subfamily.
messages: Cell membrane
messages: Interacts with MinC and FtsZ.

243274:THEMA RS05160
gene id: 243274:THEMA_RS05160
uniprot id: Q9X2B8
uniprot id: R4P295
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

243274:THEMA RS04200
gene id: 243274:THEMA_RS04200
uniprot id: Q9WXW7
uniprot id: R4NMR7
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS08625
gene id: 243274:THEMA_RS08625
uniprot id: G4FEM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

243274:THEMA RS08395
gene id: 243274:THEMA_RS08395
uniprot id: G4FEH4
uniprot id: Q9X0Q4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

243274:THEMA RS03020
gene id: 243274:THEMA_RS03020
uniprot id: Q9WYH1
names: Activity Regulation
names: Biotechnology
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Esterase 10 family.
messages: Exhibits significant esterase activity with a preference for short acyl chain esters (C4-C8) in vitro. Its physiological function is not known. Displays neither proteolytic activity using casein as substrate, nor peptidase activity when assayed with L-leucine p-nitroanilide and L-proline p-nitroanilide.
messages: Exists mainly as a monomer and, to some extent as a dimer.
messages: Is strongly inhibited by phenylmethylsulfonyl fluoride, a serine protease inhibitor, and by mercury chloride. Diethyl pyrocarbonate, a histidine modifier, also inhibits the reaction, albeit less pronounced than phenylmethylsulfonyl fluoride. EDTA and dithiothreitol have no effect on enzyme activity.
messages: The high thermal stability and activity in the presence of organic solvents makes EstD an attractive catalyst for future applications in industry.

243274:THEMA RS01800
gene id: 243274:THEMA_RS01800
uniprot id: G4FDP6
uniprot id: Q9WZ44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

243274:THEMA RS06145
gene id: 243274:THEMA_RS06145
uniprot id: Q9X1U3
uniprot id: R4P1D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

243274:THEMA RS08450
gene id: 243274:THEMA_RS08450
uniprot id: Q9X0P4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

243274:THEMA RS02225
gene id: 243274:THEMA_RS02225
uniprot id: G4FDY0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class U subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

243274:THEMA RS00385
gene id: 243274:THEMA_RS00385
uniprot id: G4FCX3
uniprot id: Q9WZV5
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

243274:THEMA RS02040
gene id: 243274:THEMA_RS02040
uniprot id: Q9WYZ7
uniprot id: R4NYE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

243274:THEMA RS00620
gene id: 243274:THEMA_RS00620
uniprot id: Q9WZR3
uniprot id: R4NZI9
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS03015
gene id: 243274:THEMA_RS03015
uniprot id: G4FHQ0
uniprot id: Q9WYH2
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

243274:THEMA RS09445
gene id: 243274:THEMA_RS09445
uniprot id: G4FF26
uniprot id: Q9X059
names: Function
names: Similarity
messages: Belongs to the LarC family.
messages: Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.

243274:THEMA RS06855
gene id: 243274:THEMA_RS06855
uniprot id: G4FFL0
uniprot id: Q9X1I3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Binds 1 zinc ion per subunit.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity (By similarity).
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

243274:THEMA RS02510
gene id: 243274:THEMA_RS02510
uniprot id: Q9WYS1
names: Function
names: Similarity
messages: Belongs to the UxaE family.
messages: Catalyzes the epimerization of D-tagaturonate (D-TagA) to D-fructuronate (D-FruA).

243274:THEMA RS02925
gene id: 243274:THEMA_RS02925
uniprot id: Q9WYJ0
uniprot id: R4P086
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

243274:THEMA RS06040
gene id: 243274:THEMA_RS06040
uniprot id: G4FG16
uniprot id: Q9X1W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

243274:THEMA RS07445
gene id: 243274:THEMA_RS07445
uniprot id: Q9X182
uniprot id: R4P303
names: Similarity
messages: Belongs to the GSP E family.

243274:THEMA RS08345
gene id: 243274:THEMA_RS08345
uniprot id: Q9X0R4
uniprot id: R4P2J7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

243274:THEMA RS06080
gene id: 243274:THEMA_RS06080
uniprot id: Q9X1V4
uniprot id: R4P1N5
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

243274:THEMA RS08945
gene id: 243274:THEMA_RS08945
uniprot id: Q9X0F5
uniprot id: R4P271
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS03435
gene id: 243274:THEMA_RS03435
uniprot id: P56944
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

243274:THEMA RS08170
gene id: 243274:THEMA_RS08170
uniprot id: Q9X0U3
uniprot id: R4P0M1
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

243274:THEMA RS01500
gene id: 243274:THEMA_RS01500
uniprot id: Q9WZA0
uniprot id: R4P111
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

243274:THEMA RS02080
gene id: 243274:THEMA_RS02080
uniprot id: G4FDV1
uniprot id: Q9WYZ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS00180
gene id: 243274:THEMA_RS00180
uniprot id: G4FCT4
uniprot id: Q9WZZ3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

243274:THEMA RS07890
gene id: 243274:THEMA_RS07890
uniprot id: G4FE75
uniprot id: Q9X100
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

243274:THEMA RS06350
gene id: 243274:THEMA_RS06350
uniprot id: G4FFV9
uniprot id: Q9X1Q7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

243274:THEMA RS03870
gene id: 243274:THEMA_RS03870
uniprot id: G4FH92
uniprot id: Q9WY22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

243274:THEMA RS07500
gene id: 243274:THEMA_RS07500
uniprot id: G4FF87
uniprot id: Q9X172
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

243274:THEMA RS06895
gene id: 243274:THEMA_RS06895
uniprot id: G4FFK2
uniprot id: Q9X1H7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

243274:THEMA RS04645
gene id: 243274:THEMA_RS04645
uniprot id: Q9WXN0
uniprot id: R4NP39
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

243274:THEMA RS04025
gene id: 243274:THEMA_RS04025
uniprot id: Q9WXZ4
uniprot id: R4NPG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

243274:THEMA RS06120
gene id: 243274:THEMA_RS06120
uniprot id: G4FG00
uniprot id: Q9X1U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

243274:THEMA RS03780
gene id: 243274:THEMA_RS03780
uniprot id: Q9WY33
uniprot id: R4NXH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

243274:THEMA RS07255
gene id: 243274:THEMA_RS07255
uniprot id: G4FFD2
uniprot id: Q9X1B6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

243274:THEMA RS07145
gene id: 243274:THEMA_RS07145
uniprot id: G4FFF2
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

243274:THEMA RS07405
gene id: 243274:THEMA_RS07405
uniprot id: Q9X189
uniprot id: R4NR72
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

243274:THEMA RS08010
gene id: 243274:THEMA_RS08010
uniprot id: G4FE99
uniprot id: Q9X0X6
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

243274:THEMA RS04910
gene id: 243274:THEMA_RS04910
uniprot id: G4FGN6
uniprot id: R4P4D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS07530
gene id: 243274:THEMA_RS07530
uniprot id: G4FF81
uniprot id: Q9X166
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

243274:THEMA RS07330
gene id: 243274:THEMA_RS07330
uniprot id: G4FFB9
uniprot id: Q9X1A3
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

243274:THEMA RS01890
gene id: 243274:THEMA_RS01890
uniprot id: G4FDR4
uniprot id: Q9WZ27
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS01050
gene id: 243274:THEMA_RS01050
uniprot id: G4FDA1
uniprot id: Q9WZI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

243274:THEMA RS00645
gene id: 243274:THEMA_RS00645
uniprot id: G4FD23
uniprot id: Q9WZQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

243274:THEMA RS08860
gene id: 243274:THEMA_RS08860
uniprot id: G4FER6
uniprot id: O33927
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: No consensus sequence similar to the SOS-box from E.coli or from B.subtilis was found upstream of the lexA gene, suggesting the presence of another target sequence specific for the Thermotogales.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

243274:THEMA RS07265
gene id: 243274:THEMA_RS07265
uniprot id: G4FFD0
uniprot id: Q9X1B4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

243274:THEMA RS03395
gene id: 243274:THEMA_RS03395
uniprot id: Q9WYA0
uniprot id: R4NPR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

243274:THEMA RS09550
gene id: 243274:THEMA_RS09550
uniprot id: G4FF47
uniprot id: P36205
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under conditions of nitrogen excess, feedback-inhibited GlnA forms a stable complex with TnrA, which inhibits its DNA-binding activity. In contrast, feedback-inhibited GlnA acts as a chaperone to stabilize the DNA-binding activity of GlnR, which represses the transcription of nitrogen assimilation genes.
messages: Inhibited by glutamine.
messages: Oligomer of 12 subunits arranged in the form of two hexagons. In its feedback-inhibited form, interacts with TnrA in order to block its DNA-binding activity.

243274:THEMA RS03625
gene id: 243274:THEMA_RS03625
uniprot id: G4FHD0
uniprot id: Q9WY59
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

243274:THEMA RS00845
gene id: 243274:THEMA_RS00845
uniprot id: Q9WZM0
uniprot id: R4NZF6
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS00070
gene id: 243274:THEMA_RS00070
uniprot id: Q9X015
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the nucleoside triphosphate pyrophosphohydrolase family.
messages: Catalyzes the hydrolysis of all eight canonical ribonucleoside triphosphates (NTP) and deoxyribonucleoside triphosphates (dNTP) to their corresponding nucleoside monophosphates ((d)NMP) and PPi and subsequently hydrolyzes the resultant PPi to Pi. The NTPase activity with deoxyribonucleoside triphosphates as substrate is higher than corresponding ribonucleoside triphosphates. dGTP is the best substrate among the deoxyribonucleoside triphosphates, and GTP is the best among the ribonucleoside triphosphates.
messages: Homodimer.
messages: Inhibited by AMPCPP (alpha,beta-methyleneadenosine triphosphate).

243274:THEMA RS03705
gene id: 243274:THEMA_RS03705
uniprot id: G4FHB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DisA family.
messages: Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
messages: Homooctamer.
messages: Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.

243274:THEMA RS02820
gene id: 243274:THEMA_RS02820
uniprot id: Q9WYK9
uniprot id: R4NY10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS08795
gene id: 243274:THEMA_RS08795
uniprot id: G4FEQ3
uniprot id: Q9X0H9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

243274:THEMA RS02385
gene id: 243274:THEMA_RS02385
uniprot id: Q9ZHG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the PolIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).

243274:THEMA RS04335
gene id: 243274:THEMA_RS04335
uniprot id: G4FH00
names: Similarity
messages: Belongs to the FlgM family.

243274:THEMA RS00985
gene id: 243274:THEMA_RS00985
uniprot id: G4FD89
uniprot id: Q9WZJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

243274:THEMA RS06920
gene id: 243274:THEMA_RS06920
uniprot id: G4FFJ7
uniprot id: Q9X1H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

243274:THEMA RS07110
gene id: 243274:THEMA_RS07110
uniprot id: G4FFF9
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

243274:THEMA RS07880
gene id: 243274:THEMA_RS07880
uniprot id: Q9X102
uniprot id: R4P0J7
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

243274:THEMA RS07740
gene id: 243274:THEMA_RS07740
uniprot id: Q9X129
uniprot id: R4P0M0
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS09025
gene id: 243274:THEMA_RS09025
uniprot id: Q9X0D9
uniprot id: R4P043
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

243274:THEMA RS02650
gene id: 243274:THEMA_RS02650
uniprot id: Q9WYP3
uniprot id: R4NY41
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of scyllo-inosose (2-keto-myo-inositol) to 3-dehydro-scyllo-inosose (diketo-inositol), and thus probably functions in a myo-inositol degradation pathway together with IolG, IolN and IolO. Has no activity on myo-inositol, D-chiro-inositol and 1-keto-D-chiro-inositol.
messages: Homodimer.

243274:THEMA RS00700
gene id: 243274:THEMA_RS00700
uniprot id: Q9WZP7
names: Function
names: Similarity
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: In the C-terminal section; belongs to the ThiN family.
messages: In the N-terminal section; belongs to the ThiD family.

243274:THEMA RS05490
gene id: 243274:THEMA_RS05490
uniprot id: Q9X258
uniprot id: R4P450
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

243274:THEMA RS03550
gene id: 243274:THEMA_RS03550
uniprot id: G4FHE5
uniprot id: Q9WY73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

243274:THEMA RS04430
gene id: 243274:THEMA_RS04430
uniprot id: G4FGY1
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

243274:THEMA RS06190
gene id: 243274:THEMA_RS06190
uniprot id: Q9X1T4
uniprot id: R4NRU1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

243274:THEMA RS00250
gene id: 243274:THEMA_RS00250
uniprot id: P42848
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Homooctamer. Forms a ring-shaped particle.
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein (By similarity). Inhibited by fluoride and phosphate.

243274:THEMA RS01150
gene id: 243274:THEMA_RS01150
uniprot id: G4FDC1
uniprot id: Q9S5X1
names: Similarity
messages: Belongs to the CinA family.

243274:THEMA RS08655
gene id: 243274:THEMA_RS08655
uniprot id: Q9X0K6
uniprot id: R4P0C2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

243274:THEMA RS06460
gene id: 243274:THEMA_RS06460
uniprot id: G4FFT7
uniprot id: Q9X1N5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. WecA subfamily.
messages: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55), the lipid intermediate involved in the synthesis of various bacterial cell envelope components. The enzyme is highly active when tested with C35-P, instead of its natural C55-P lipid substrate, suggesting that at least a 35-carbon chain is required for the lipid to be a substrate of WecA.
messages: Cell membrane
messages: Membrane
messages: Partially inhibited by magnesium at concentration higher than 10 mM and totally inhibited at concentration higher than 250 mM. Also inhibited by tunicamycin, NaCl and KCl.

243274:THEMA RS06045
gene id: 243274:THEMA_RS06045
uniprot id: G4FG15
uniprot id: Q9X1W1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

243274:THEMA RS03300
gene id: 243274:THEMA_RS03300
uniprot id: Q9WYB7
uniprot id: R4NNA3
names: Similarity
messages: Belongs to the glycosyl hydrolase 51 family.

243274:THEMA RS04660
gene id: 243274:THEMA_RS04660
uniprot id: G4FGT6
uniprot id: Q9WXM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

243274:THEMA RS07125
gene id: 243274:THEMA_RS07125
uniprot id: Q9X1D7
names: Cofactor
names: Function
messages: Binds 1 [2Fe-2S] cluster.
messages: Might be part of a multi-protein complex, possibly involved in metal cluster assembly.

243274:THEMA RS01960
gene id: 243274:THEMA_RS01960
uniprot id: Q9WZ13
uniprot id: R4NNY7
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS00310
gene id: 243274:THEMA_RS00310
uniprot id: Q9WZW9
uniprot id: R4NZN1
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS02050
gene id: 243274:THEMA_RS02050
uniprot id: G4FDU6
uniprot id: Q9WYZ5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

243274:THEMA RS08190
gene id: 243274:THEMA_RS08190
uniprot id: Q9X0T9
uniprot id: R4P2M8
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS02555
gene id: 243274:THEMA_RS02555
uniprot id: Q9WYR2
uniprot id: R4P0F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS08220
gene id: 243274:THEMA_RS08220
uniprot id: Q9X0T3
uniprot id: R4P0L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS06505
gene id: 243274:THEMA_RS06505
uniprot id: Q9X1M7
uniprot id: R4P3G4
names: Subcellular Location Annotation
messages: Periplasm

243274:THEMA RS02250
gene id: 243274:THEMA_RS02250
uniprot id: Q9WYV5
uniprot id: R4NYK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS02860
gene id: 243274:THEMA_RS02860
uniprot id: Q9WYK2
uniprot id: R4NQ09
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS06495
gene id: 243274:THEMA_RS06495
uniprot id: Q9X1M9
uniprot id: R4NRN0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

243274:THEMA RS01870
gene id: 243274:THEMA_RS01870
uniprot id: G4FDR0
uniprot id: Q9WZ31
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Cell inner membrane
messages: Homopentamer (PubMed:22722933, PubMed:23781956, PubMed:16902408, PubMed:16598263, PubMed:16857941, PubMed:23112165, PubMed:23425532, PubMed:26871634). In the absence of Mg(2+), interactions between subunits are weakened, and dimers, trimers and tetramers can be observed in vitro (PubMed:22722933, PubMed:26871634).
messages: Inhibited by cobalt hexaammine.
messages: Mediates influx of magnesium ions (PubMed:18276588, PubMed:22722933, PubMed:23781956, PubMed:23112165). Mediates Co(2+) uptake (PubMed:21454699, PubMed:23091000, PubMed:23425532). Has high selectivity for Co(2+) (PubMed:21454699, PubMed:23425532). Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high (PubMed:23112165, PubMed:23425532, PubMed:26871634).
messages: Mediates influx of magnesium ions.
messages: Membrane
messages: The central ion permeation pathway is formed by the first transmembrane domain from each of the five subunits. Mg(2+) binding strengthens interactions between subunits and leads to the formation of a symmetrical homopentamer surrounding a closed ion permeation pathway (PubMed:23091000, PubMed:16902408, PubMed:16598263, PubMed:16857941, PubMed:23112165, PubMed:23425532, PubMed:26871634). Co(2+) binding also induces a conformation change (PubMed:21454699). Low Mg(2+) concentrations trigger both a conformation change within each subunit and a loosening of the interactions between subunits. This results in an open ion conduction pathway. In addition, this results in a less symmetrical shape of the whole complex (PubMed:23112165, PubMed:26871634).

243274:THEMA RS00005
gene id: 243274:THEMA_RS00005
uniprot id: G4FF64
uniprot id: P46798
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

243274:THEMA RS03615
gene id: 243274:THEMA_RS03615
uniprot id: Q9WY61
uniprot id: R4NXX5
names: Subcellular Location Annotation
messages: Cytoplasm

243274:THEMA RS05335
gene id: 243274:THEMA_RS05335
uniprot id: G4FGF2
uniprot id: Q9X286
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
messages: Monomer or homodimer; in equilibrium, with a preference for the monomer. Dimerization may be employed to package NusB in an inactive form until recruitment into antitermination complexes.

243274:THEMA RS00265
gene id: 243274:THEMA_RS00265
uniprot id: Q9WZX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family. TsaB subfamily.
messages: Cytoplasm
messages: Homodimer (PubMed:20944216). Forms an hexamer composed of two TsaB, TsaD and TsaE trimers (PubMed:29741707).
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaE; this reaction does not require ATP in vitro. TsaB seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity).

243274:THEMA RS09960
gene id: 243274:THEMA_RS09960
uniprot id: Q9WYT4
uniprot id: R4NNQ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

243274:THEMA RS02215
gene id: 243274:THEMA_RS02215
uniprot id: G4FDX8
uniprot id: Q9WYW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

243274:THEMA RS06370
gene id: 243274:THEMA_RS06370
uniprot id: G4FFV5
uniprot id: Q9X1Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

243274:THEMA RS07090
gene id: 243274:THEMA_RS07090
uniprot id: G4FFG3
uniprot id: Q9X1E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell membrane
messages: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.
messages: Membrane

243274:THEMA RS03935
gene id: 243274:THEMA_RS03935
uniprot id: G4FH79
uniprot id: Q9WY12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

243274:THEMA RS04270
gene id: 243274:THEMA_RS04270
uniprot id: G4FH13
uniprot id: Q9WXV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

243274:THEMA RS07935
gene id: 243274:THEMA_RS07935
uniprot id: Q9X0Z1
uniprot id: R4P2U2
names: Function
names: Similarity
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.

243274:THEMA RS03925
gene id: 243274:THEMA_RS03925
uniprot id: G4FH81
uniprot id: Q9WY14
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

243274:THEMA RS05015
gene id: 243274:THEMA_RS05015
uniprot id: Q9X2E8
uniprot id: R4P2B8
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

243274:THEMA RS08850
gene id: 243274:THEMA_RS08850
uniprot id: G4FER4
uniprot id: O33926
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

243274:THEMA RS01205
gene id: 243274:THEMA_RS01205
uniprot id: G4FDD2
uniprot id: Q9WZF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

243274:THEMA RS07350
gene id: 243274:THEMA_RS07350
uniprot id: G4FFB5
uniprot id: Q9X199
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS08745
gene id: 243274:THEMA_RS08745
uniprot id: Q9X0I8
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS08225
gene id: 243274:THEMA_RS08225
uniprot id: Q9X0T2
uniprot id: R4NSC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS02045
gene id: 243274:THEMA_RS02045
uniprot id: G4FDU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

243274:THEMA RS07675
gene id: 243274:THEMA_RS07675
uniprot id: Q9X143
uniprot id: R4P2X6
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

243274:THEMA RS08445
gene id: 243274:THEMA_RS08445
uniprot id: G4FEI4
uniprot id: Q9X0P5
names: Similarity
messages: Belongs to the UPF0173 family.

243274:THEMA RS06635
gene id: 243274:THEMA_RS06635
uniprot id: G4FFQ4
uniprot id: Q9X1K5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

243274:THEMA RS04395
gene id: 243274:THEMA_RS04395
uniprot id: G4FGY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS07320
gene id: 243274:THEMA_RS07320
uniprot id: G4FFC1
uniprot id: Q9X1A5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. Does not have phosphomannose isomerase (PMI) activity. Isomerization proceeds through a cis-enediol-based mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Optimal activity is achieved when His-310 and Lys-422 are both present to open the sugar ring, and Glu-281 catalyzes the isomerization step (PubMed:33422670). Activity is decreased in the presence of the PGI inhibitor 6-phosphogluconate (PubMed:33422670).

243274:THEMA RS03640
gene id: 243274:THEMA_RS03640
uniprot id: G4FHC7
uniprot id: Q9WY56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

243274:THEMA RS06960
gene id: 243274:THEMA_RS06960
uniprot id: G4FFI9
uniprot id: Q9X1G5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

243274:THEMA RS03325
gene id: 243274:THEMA_RS03325
uniprot id: G4FHJ0
uniprot id: Q9WYB3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arabinose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of L-arabinose to L-ribulose.

243274:THEMA RS02150
gene id: 243274:THEMA_RS02150
uniprot id: G4FDW5
uniprot id: Q9WYX6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

243274:THEMA RS02430
gene id: 243274:THEMA_RS02430
uniprot id: G4FE18
uniprot id: P35874
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with SecDF, and other proteins may be involved. The channel interacts with SecA via subunit SecY.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Essential subunit of the protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

243274:THEMA RS02870
gene id: 243274:THEMA_RS02870
uniprot id: G4FHS8
uniprot id: Q9WYK0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

243274:THEMA RS05785
gene id: 243274:THEMA_RS05785
uniprot id: Q9X205
uniprot id: R4P1K4
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

243274:THEMA RS07085
gene id: 243274:THEMA_RS07085
uniprot id: G4FFG4
uniprot id: Q9X1E3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism.
messages: Membrane

243274:THEMA RS03265
gene id: 243274:THEMA_RS03265
uniprot id: Q9WYC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane

243274:THEMA RS03675
gene id: 243274:THEMA_RS03675
uniprot id: G4FHC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

243274:THEMA RS05520
gene id: 243274:THEMA_RS05520
uniprot id: G4FGB6
uniprot id: Q56313
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

243274:THEMA RS01390
gene id: 243274:THEMA_RS01390
uniprot id: G4FDG9
uniprot id: Q9WZC3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain (Probable).
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

243274:THEMA RS08295
gene id: 243274:THEMA_RS08295
uniprot id: G4FEF5
uniprot id: O33836
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

243274:THEMA RS08930
gene id: 243274:THEMA_RS08930
uniprot id: Q9S5X4
uniprot id: R4NRY3
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

243274:THEMA RS07020
gene id: 243274:THEMA_RS07020
uniprot id: G4FFH7
uniprot id: Q9X1F5
names: Function
names: PTM
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.
messages: In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts an anti-sigma factor and thus releases a sigma factor from inhibition.
messages: Phosphorylated on a serine residue.

243274:THEMA RS06215
gene id: 243274:THEMA_RS06215
uniprot id: Q9X1S9
uniprot id: R4NRT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

243274:THEMA RS08940
gene id: 243274:THEMA_RS08940
uniprot id: Q9X0F6
uniprot id: R4NZW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS08260
gene id: 243274:THEMA_RS08260
uniprot id: Q9X0S5
uniprot id: R4P0A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS03985
gene id: 243274:THEMA_RS03985
uniprot id: Q9WY03
uniprot id: R4NXE1
names: Similarity
messages: Belongs to the alkaline phosphatase family.

243274:THEMA RS05410
gene id: 243274:THEMA_RS05410
uniprot id: Q9X274
uniprot id: R4P1V9
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

243274:THEMA RS01820
gene id: 243274:THEMA_RS01820
uniprot id: Q9WZ40
uniprot id: R4P0U1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

243274:THEMA RS06000
gene id: 243274:THEMA_RS06000
uniprot id: Q9X1X0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

243274:THEMA RS02395
gene id: 243274:THEMA_RS02395
uniprot id: P36252
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

243274:THEMA RS01790
gene id: 243274:THEMA_RS01790
uniprot id: G4FDP4
uniprot id: Q9ZHF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

243274:THEMA RS06030
gene id: 243274:THEMA_RS06030
uniprot id: G4FG18
uniprot id: Q9X1W4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

243274:THEMA RS05955
gene id: 243274:THEMA_RS05955
uniprot id: G4FG33
uniprot id: Q9X1X7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm
messages: Inhibited by 4,5 dithiohydroxyphthalic acid (DTHPA) analogs, which bind to the catalytic iron site of the [4Fe-4S] cluster.

243274:THEMA RS01220
gene id: 243274:THEMA_RS01220
uniprot id: G4FDD5
uniprot id: P36204
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: In the C-terminal section; belongs to the triosephosphate isomerase family.
messages: In the N-terminal section; belongs to the phosphoglycerate kinase family.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
messages: Monomer (PGK) and homotetramer (PGK-TIM).
messages: Monomer.

243274:THEMA RS09055
gene id: 243274:THEMA_RS09055
uniprot id: Q9X0D3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

243274:THEMA RS05965
gene id: 243274:THEMA_RS05965
uniprot id: P96111
names: Similarity
messages: In the C-terminal section; belongs to the PyrI family.
messages: In the N-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

243274:THEMA RS07945
gene id: 243274:THEMA_RS07945
uniprot id: Q9X0Y9
uniprot id: R4NSK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

243274:THEMA RS06135
gene id: 243274:THEMA_RS06135
uniprot id: G4FFZ7
uniprot id: Q9X1U5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

243274:THEMA RS05280
gene id: 243274:THEMA_RS05280
uniprot id: Q9X297
uniprot id: R4NSE6
names: Similarity
messages: Belongs to the Fur family.

243274:THEMA RS06055
gene id: 243274:THEMA_RS06055
uniprot id: Q9X1V9
uniprot id: R4P1P3
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

243274:THEMA RS03970
gene id: 243274:THEMA_RS03970
uniprot id: G4FH72
uniprot id: Q9WY05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

243274:THEMA RS03710
gene id: 243274:THEMA_RS03710
uniprot id: Q9WY42
uniprot id: R4NZU6
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

243274:THEMA RS03885
gene id: 243274:THEMA_RS03885
uniprot id: Q9WY19
uniprot id: R4NXG3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

243274:THEMA RS03195
gene id: 243274:THEMA_RS03195
uniprot id: Q9WYD8
uniprot id: R4NPV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243274:THEMA RS03060
gene id: 243274:THEMA_RS03060
uniprot id: R4NPX5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

243274:THEMA RS05550
gene id: 243274:THEMA_RS05550
uniprot id: G4FGB1
uniprot id: Q9X248
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

243274:THEMA RS02165
gene id: 243274:THEMA_RS02165
uniprot id: Q9WYX2
uniprot id: R4NYC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS04985
gene id: 243274:THEMA_RS04985
uniprot id: Q9X2F4
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Is able to hydrolyze various linear maltooligosaccharides (maltotriose to maltoheptaose) and cyclomaltodextrins (CDs), to mainly glucose and maltose, by liberating glucose from the reducing end of the molecules. Shows a very weak activity on starch. Can neither hydrolyze maltose nor degrade pullulan, but rapidly hydrolyzes acarbose, a strong amylase and glucosidase inhibitor, to acarviosine and glucose.
messages: Mn(2+), Co(2+), Zn(2+), Fe(2+), Mg(2+), and Ca(2+) inhibit the hydrolysis activity of the enzyme whereas EGTA and EDTA do not affect the activity.

243274:THEMA RS05400
gene id: 243274:THEMA_RS05400
uniprot id: G4FGE0
uniprot id: Q9X276
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family.
messages: Cytoplasm

243274:THEMA RS01180
gene id: 243274:THEMA_RS01180
uniprot id: Q9WZG1
uniprot id: R4NZ68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

243274:THEMA RS01450
gene id: 243274:THEMA_RS01450
uniprot id: Q9WZB1
uniprot id: R4P121
names: Similarity
messages: Belongs to the intimin/invasin family.

243274:THEMA RS00455
gene id: 243274:THEMA_RS00455
uniprot id: Q9WZU1
uniprot id: R4NZB9
names: Similarity
messages: Belongs to the GSP E family.

243274:THEMA RS08885
gene id: 243274:THEMA_RS08885
uniprot id: G4FES1
uniprot id: Q9X0G6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

243274:THEMA RS02765
gene id: 243274:THEMA_RS02765
uniprot id: Q9WYL9
uniprot id: R4NQ27
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS00155
gene id: 243274:THEMA_RS00155
uniprot id: Q9WZZ8
uniprot id: R4P1Q6
names: Caution
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS01975
gene id: 243274:THEMA_RS01975
uniprot id: Q9WZ10
uniprot id: R4NYQ7
names: Similarity
messages: Belongs to the class-I fumarase family.

243274:THEMA RS03965
gene id: 243274:THEMA_RS03965
uniprot id: G4FH73
uniprot id: Q9WY06
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

243274:THEMA RS02375
gene id: 243274:THEMA_RS02375
uniprot id: Q9WYT5
names: Function
messages: Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.

243274:THEMA RS01175
gene id: 243274:THEMA_RS01175
uniprot id: Q9WZG2
uniprot id: R4P178
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

243274:THEMA RS01270
gene id: 243274:THEMA_RS01270
uniprot id: Q9WZE6
uniprot id: R4NYV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheX chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).
messages: Interacts (via N-terminus) with unphosphorylated CheY. Interacts (via central domain) with FliG (via central domain or via central domain and C-terminus).
messages: Membrane

243274:THEMA RS05275
gene id: 243274:THEMA_RS05275
uniprot id: Q9X298
uniprot id: R4NU08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

243274:THEMA RS07025
gene id: 243274:THEMA_RS07025
uniprot id: G4FFH6
uniprot id: Q9X1F4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS01950
gene id: 243274:THEMA_RS01950
uniprot id: G4FDS6
uniprot id: Q9WZ15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

243274:THEMA RS03405
gene id: 243274:THEMA_RS03405
uniprot id: Q9WY98
uniprot id: R4NXS3
names: Similarity
messages: Belongs to the UPF0111 family.

243274:THEMA RS04220
gene id: 243274:THEMA_RS04220
uniprot id: G4FH23
uniprot id: Q9WXW3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS08390
gene id: 243274:THEMA_RS08390
uniprot id: Q9X0Q5
uniprot id: R4P075
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

243274:THEMA RS01910
gene id: 243274:THEMA_RS01910
uniprot id: G4FDR8
uniprot id: Q9WZ23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

243274:THEMA RS07440
gene id: 243274:THEMA_RS07440
uniprot id: G4FF99
uniprot id: Q9X183
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1 (By similarity).
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

243274:THEMA RS06280
gene id: 243274:THEMA_RS06280
uniprot id: Q9X1S1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycerate kinase type-1 family.
messages: Homodimer.
messages: Involved in the degradation of serine via 3-hydroxypyruvate. Catalyzes the ATP-dependent phosphorylation of D-glycerate to 2-phosphoglycerate.

243274:THEMA RS01770
gene id: 243274:THEMA_RS01770
uniprot id: Q9WZ48
uniprot id: R4NYV0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

243274:THEMA RS06445
gene id: 243274:THEMA_RS06445
uniprot id: Q9X1N8
uniprot id: R4P185
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

243274:THEMA RS03475
gene id: 243274:THEMA_RS03475
uniprot id: Q9WY88
uniprot id: R4NN82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

243274:THEMA RS04030
gene id: 243274:THEMA_RS04030
uniprot id: G4FH60
uniprot id: Q9WXZ3
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

243274:THEMA RS03930
gene id: 243274:THEMA_RS03930
uniprot id: Q9WY13
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

243274:THEMA RS07045
gene id: 243274:THEMA_RS07045
uniprot id: G4FFH2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

243274:THEMA RS04670
gene id: 243274:THEMA_RS04670
uniprot id: Q56317
names: Cofactor
names: Subunit
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

243274:THEMA RS05290
gene id: 243274:THEMA_RS05290
uniprot id: G4FGG1
uniprot id: Q9X295
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

243274:THEMA RS08785
gene id: 243274:THEMA_RS08785
uniprot id: G4FEQ1
uniprot id: Q9X0I1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

243274:THEMA RS01780
gene id: 243274:THEMA_RS01780
uniprot id: Q9WZ47
uniprot id: R4NQK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

243274:THEMA RS03375
gene id: 243274:THEMA_RS03375
uniprot id: G4FHI0
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

243274:THEMA RS06060
gene id: 243274:THEMA_RS06060
uniprot id: G4FG12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

243274:THEMA RS03620
gene id: 243274:THEMA_RS03620
uniprot id: G4FHD1
uniprot id: Q9WY60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

243274:THEMA RS06555
gene id: 243274:THEMA_RS06555
uniprot id: Q9X1L7
uniprot id: R4P3F4
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

243274:THEMA RS01560
gene id: 243274:THEMA_RS01560
uniprot id: Q9WZ89
uniprot id: R4NP74
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS04080
gene id: 243274:THEMA_RS04080
uniprot id: G4FH51
uniprot id: P50908
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

243274:THEMA RS08025
gene id: 243274:THEMA_RS08025
uniprot id: Q9X0X3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
messages: Purl possesses an auxiliary ATP Binding region which is not catalytic, but able to bind additional ATP. The conformational changes associated with its binding could have a regulatory role in formation of the PurLSQ complex (PubMed:17154526).

243274:THEMA RS00060
gene id: 243274:THEMA_RS00060
uniprot id: G4FCR1
uniprot id: Q9X017
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

243274:THEMA RS03030
gene id: 243274:THEMA_RS03030
uniprot id: Q9WYG9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

243274:THEMA RS08000
gene id: 243274:THEMA_RS08000
uniprot id: Q9X0X8
uniprot id: R4NQZ4
names: Similarity
messages: Belongs to the AIR synthase family.

243274:THEMA RS04765
gene id: 243274:THEMA_RS04765
uniprot id: Q9X2I6
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

243274:THEMA RS05860
gene id: 243274:THEMA_RS05860
uniprot id: Q9X1Z1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (Probable). Expression of the complex plus RibU in E.coli allows riboflavin uptake; uptake does not occur in the absence of RibU or the EcfA1A2T complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell inner membrane
messages: Forms a heterodimer with EcfA2. Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component, RibU, BioY), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component) upon coexpression in E.coli. Stable subcomplexes with both A plus T components can also be isolated. This complex interacts with at least 2 substrate-specific components, BioY and RibU.
messages: Structure 4HLU is probably in the open state.

243274:THEMA RS03540
gene id: 243274:THEMA_RS03540
uniprot id: Q9WY75
uniprot id: R4NY16
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS07635
gene id: 243274:THEMA_RS07635
uniprot id: Q9X148
uniprot id: R4NR41
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

243274:THEMA RS08035
gene id: 243274:THEMA_RS08035
uniprot id: Q9X0X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Homodimer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

243274:THEMA RS06785
gene id: 243274:THEMA_RS06785
uniprot id: G4FFM4
uniprot id: Q9ZAE6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

243274:THEMA RS06760
gene id: 243274:THEMA_RS06760
uniprot id: G4FFM9
uniprot id: P38514
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

243274:THEMA RS05545
gene id: 243274:THEMA_RS05545
uniprot id: R4P234
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

243274:THEMA RS04680
gene id: 243274:THEMA_RS04680
uniprot id: Q56316
names: Cofactor
names: Subunit
messages: Binds 2 [4Fe-4S] clusters.
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

243274:THEMA RS00625
gene id: 243274:THEMA_RS00625
uniprot id: Q9WZR2
uniprot id: R4NRA0
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS01920
gene id: 243274:THEMA_RS01920
uniprot id: G4FDS0
uniprot id: Q9WZ21
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS03120
gene id: 243274:THEMA_RS03120
uniprot id: Q9WYF3
uniprot id: R4NPW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

243274:THEMA RS03520
gene id: 243274:THEMA_RS03520
uniprot id: G4FHF1
uniprot id: Q9WY79
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Catalyzes the addition of both L- and D-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use meso-diaminopimelate as the amino acid substrate in vitro, although much less efficiently.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The peptidoglycan of T.maritima was shown to contain approximate amounts of both enantiomers of lysine and no diaminopimelate.

243274:THEMA RS00050
gene id: 243274:THEMA_RS00050
uniprot id: Q9X019
uniprot id: R4NZJ0
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS03045
gene id: 243274:THEMA_RS03045
uniprot id: G4FHP4
uniprot id: Q9WYG6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS00275
gene id: 243274:THEMA_RS00275
uniprot id: G4FCV3
uniprot id: Q9WZX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

243274:THEMA RS08960
gene id: 243274:THEMA_RS08960
uniprot id: Q9X0F2
uniprot id: R4NQD9
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

243274:THEMA RS05495
gene id: 243274:THEMA_RS05495
uniprot id: G4FGC1
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS03805
gene id: 243274:THEMA_RS03805
uniprot id: Q9WY30
names: Activity Regulation
names: Function
messages: Can function in vivo with either divalent iron or manganese occupying di- and trimetal sites. Dimetal is necessary and sufficient to catalyze conversion of c-di-GMP to pGpG, but conversion of pGpG to GMP requires an occupied trimetal site.
messages: Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP) to GMP. Hydrolyzes c-di-GMP to GMP in a two-step reaction, via the linear intermediate 5'-phosphoguanylyl(3'->5')guanosine (pGpG).

243274:THEMA RS04110
gene id: 243274:THEMA_RS04110
uniprot id: Q9WXY4
uniprot id: R4NXB7
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS06220
gene id: 243274:THEMA_RS06220
uniprot id: G4FFY0
uniprot id: Q9X1S8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity).
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

243274:THEMA RS08070
gene id: 243274:THEMA_RS08070
uniprot id: Q9X0W4
uniprot id: R4P0R4
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

243274:THEMA RS01225
gene id: 243274:THEMA_RS01225
uniprot id: G4FDD6
uniprot id: P17721
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD (PubMed:2271518). The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG (By similarity).
messages: Cytoplasm
messages: Homotetramer.

243274:THEMA RS02390
gene id: 243274:THEMA_RS02390
uniprot id: Q9WYT2
uniprot id: R4NYI8
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

243274:THEMA RS00200
gene id: 243274:THEMA_RS00200
uniprot id: G4FCT8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

243274:THEMA RS01275
gene id: 243274:THEMA_RS01275
uniprot id: Q9WZE5
uniprot id: R4P156
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

243274:THEMA RS04940
gene id: 243274:THEMA_RS04940
uniprot id: G4FGN0
uniprot id: O33840
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

243274:THEMA RS08790
gene id: 243274:THEMA_RS08790
uniprot id: G4FEQ2
uniprot id: Q9X0I0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

243274:THEMA RS08425
gene id: 243274:THEMA_RS08425
uniprot id: Q9X0P9
uniprot id: R4P0G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

243274:THEMA RS04840
gene id: 243274:THEMA_RS04840
uniprot id: Q9X2H3
uniprot id: R4P2E9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

243274:THEMA RS08100
gene id: 243274:THEMA_RS08100
uniprot id: Q9X0V7
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family.
messages: Catalyzes the synthesis of mannosylglucosylglycerate (MGG) from glucosylglycerate (GG) and GDP-mannose.

243274:THEMA RS00810
gene id: 243274:THEMA_RS00810
uniprot id: G4FD55
uniprot id: Q9WZM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. Binds to the 23S rRNA (By similarity).

243274:THEMA RS03260
gene id: 243274:THEMA_RS03260
uniprot id: Q9WYC5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Short' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+) can be partially replaced by Co(2+), Mn(2+) and Ni(2+).
messages: Non-allosteric.

243274:THEMA RS03240
gene id: 243274:THEMA_RS03240
uniprot id: G4FHK7
uniprot id: Q9WYC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

243274:THEMA RS09380
gene id: 243274:THEMA_RS09380
uniprot id: Q9X073
uniprot id: R4NRP2
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

243274:THEMA RS07410
gene id: 243274:THEMA_RS07410
uniprot id: Q9X188
uniprot id: R4P0R3
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

243274:THEMA RS00115
gene id: 243274:THEMA_RS00115
uniprot id: Q9X006
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CheC family.
messages: Heterodimer with CheD. The CheC-CheD heterodimer interacts with phosphorylated CheY. The CheC-CheD dimer has higher phosphatase activity than CheC alone.
messages: Involved in restoring normal CheY-P levels by dephosphorylating CheY-P. Inhibits CheD by incorporating in its fold a structural motif that mimics a CheD substrate recognition site to bait and inactivate it.

243274:THEMA RS00915
gene id: 243274:THEMA_RS00915
uniprot id: G4FD75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

243274:THEMA RS08740
gene id: 243274:THEMA_RS08740
uniprot id: Q9X0I9
uniprot id: R4NQI2
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS01980
gene id: 243274:THEMA_RS01980
uniprot id: G4FDT2
uniprot id: Q9WZ09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

243274:THEMA RS01885
gene id: 243274:THEMA_RS01885
uniprot id: G4FDR3
uniprot id: Q9WZ28
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

243274:THEMA RS05105
gene id: 243274:THEMA_RS05105
uniprot id: Q9X2C9
uniprot id: R4P207
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

243274:THEMA RS01400
gene id: 243274:THEMA_RS01400
uniprot id: G4FDH1
uniprot id: Q9WZC1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

243274:THEMA RS02015
gene id: 243274:THEMA_RS02015
uniprot id: Q9WZ02
uniprot id: R4NYE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS05430
gene id: 243274:THEMA_RS05430
uniprot id: Q9X270
uniprot id: R4NSC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS02160
gene id: 243274:THEMA_RS02160
uniprot id: Q9WYX3
uniprot id: R4NNU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243274:THEMA RS03345
gene id: 243274:THEMA_RS03345
uniprot id: Q9WYA9
uniprot id: R4NPS5
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

243274:THEMA RS08780
gene id: 243274:THEMA_RS08780
uniprot id: G4FEQ0
uniprot id: P96108
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

243274:THEMA RS00100
gene id: 243274:THEMA_RS00100
uniprot id: Q9X009
uniprot id: R4NZI0
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

243274:THEMA RS05235
gene id: 243274:THEMA_RS05235
uniprot id: G4FGH2
uniprot id: Q9X2A5
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

243274:THEMA RS01445
gene id: 243274:THEMA_RS01445
uniprot id: Q9WZB2
uniprot id: R4NYR6
names: Subcellular Location Annotation
messages: Membrane

243274:THEMA RS04785
gene id: 243274:THEMA_RS04785
uniprot id: Q9X2I2
uniprot id: R4P4E5
names: Similarity
messages: Belongs to the peptidase S16 family.

243274:THEMA RS02970
gene id: 243274:THEMA_RS02970
uniprot id: G4FHQ8
uniprot id: Q9WYI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

243274:THEMA RS01235
gene id: 243274:THEMA_RS01235
uniprot id: Q9WZF2
uniprot id: R4NQX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

243274:THEMA RS03035
gene id: 243274:THEMA_RS03035
uniprot id: G4FHP6
uniprot id: Q9WYG8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243274:THEMA RS02940
gene id: 243274:THEMA_RS02940
uniprot id: Q9WYI7
names: Similarity
messages: Belongs to the ABC transporter superfamily.

243274:THEMA RS06710
gene id: 243274:THEMA_RS06710
uniprot id: G4FFN9
uniprot id: P13537
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

243274:THEMA RS03025
gene id: 243274:THEMA_RS03025
uniprot id: Q9WYH0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.