243232:MJ RS07595
gene id: 243232:MJ_RS07595
uniprot id: Q58814
names: Similarity
messages: Belongs to the UPF0147 family.

243232:MJ RS01130
gene id: 243232:MJ_RS01130
uniprot id: Q57669
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

243232:MJ RS01270
gene id: 243232:MJ_RS01270
uniprot id: Q57692
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase CyaB family.
messages: Could catalyze the biosynthesis of cyclic AMP (cAMP) from ATP.
messages: Cytoplasm

243232:MJ RS04820
gene id: 243232:MJ_RS04820
uniprot id: Q58312
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family. Archaeal preflagellin peptidase subfamily.
messages: Cell membrane
messages: Cleaves the N-terminal leader peptide from preflagellins.

243232:MJ RS00025
gene id: 243232:MJ_RS00025
uniprot id: Q60315
names: Cofactor
names: Subunit
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.

243232:MJ RS04945
gene id: 243232:MJ_RS04945
uniprot id: Q58333
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS06745
gene id: 243232:MJ_RS06745
uniprot id: P54067
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

243232:MJ RS04980
gene id: 243232:MJ_RS04980
uniprot id: Q58340
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobH/CbiC family.
messages: Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate.
messages: Homodimer.

243232:MJ RS04885
gene id: 243232:MJ_RS04885
uniprot id: P60460
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Subunit of the protein translocation channel SecYEG. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.

243232:MJ RS07260
gene id: 243232:MJ_RS07260
uniprot id: Q58752
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Probable potassium channel protein.

243232:MJ RS08585
gene id: 243232:MJ_RS08585
uniprot id: Q59007
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Homotetramer.
messages: Inhibited to approximately 20% by EDTA.

243232:MJ RS05680
gene id: 243232:MJ_RS05680
uniprot id: Q58459
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

243232:MJ RS04720
gene id: 243232:MJ_RS04720
uniprot id: Q58293
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Monomer.
messages: Specifically methylates the N1 position of guanosine-37 in various tRNAs.

243232:MJ RS06125
gene id: 243232:MJ_RS06125
uniprot id: Q58547
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS02560
gene id: 243232:MJ_RS02560
uniprot id: Q57908
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity).

243232:MJ RS04905
gene id: 243232:MJ_RS04905
uniprot id: Q58325
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

243232:MJ RS02115
gene id: 243232:MJ_RS02115
uniprot id: Q57843
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. Can also catalyze the cleavage of fructose-1,6-bisphosphate (FBP) to glyceraldehyde-3-phosphate (GAP) and dihydroxyacetone phosphate (DHAP).
messages: Homodecamer.
messages: Inhibited by NaBH4 in the presence of FBP.

243232:MJ RS00995
gene id: 243232:MJ_RS00995
uniprot id: P54021
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

243232:MJ RS08570
gene id: 243232:MJ_RS08570
uniprot id: Q59004
names: Similarity
messages: Belongs to the archaeal ATPase family.

243232:MJ RS03215
gene id: 243232:MJ_RS03215
uniprot id: Q58026
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS08540
gene id: 243232:MJ_RS08540
uniprot id: Q58998
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homotetramer.

243232:MJ RS05915
gene id: 243232:MJ_RS05915
uniprot id: Q58505
names: Domain
names: Function
names: Subunit
messages: Homotetramer. Dimer of dimers.
messages: Part of a potassium transport system.
messages: The RCK N-terminal domain binds NAD and possibly other effectors. This is expected to cause a conformation change that regulates potassium transport.

243232:MJ RS03325
gene id: 243232:MJ_RS03325
uniprot id: Q58045
names: Similarity
messages: To M.jannaschii MJ0992.

243232:MJ RS08370
gene id: 243232:MJ_RS08370
uniprot id: Q58964
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: May be involved in metal transport.

243232:MJ RS06860
gene id: 243232:MJ_RS06860
uniprot id: P81318
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.jannaschii MJ0902.

243232:MJ RS06490
gene id: 243232:MJ_RS06490
uniprot id: Q58610
names: Similarity
messages: To M.jannaschii MJ0123 and A.aeolicus AA15.

243232:MJ RS05865
gene id: 243232:MJ_RS05865
uniprot id: Q58496
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

243232:MJ RS05285
gene id: 243232:MJ_RS05285
uniprot id: P54109
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

243232:MJ RS04550
gene id: 243232:MJ_RS04550
uniprot id: Q58258
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

243232:MJ RS00510
gene id: 243232:MJ_RS00510
uniprot id: Q57566
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.

243232:MJ RS00885
gene id: 243232:MJ_RS00885
uniprot id: Q57632
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm
messages: Homodimer or heterodimer with another histone. Dimers then assemble into higher oligomers, with the DNA wrapped around the protein core (By similarity).

243232:MJ RS05845
gene id: 243232:MJ_RS05845
uniprot id: Q58492
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Efflux system for nickel and cobalt.

243232:MJ RS06165
gene id: 243232:MJ_RS06165
uniprot id: Q58555
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

243232:MJ RS02745
gene id: 243232:MJ_RS02745
uniprot id: Q57938
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS03625
gene id: 243232:MJ_RS03625
uniprot id: P54056
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

243232:MJ RS03540
gene id: 243232:MJ_RS03540
uniprot id: Q58086
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane

243232:MJ RS01500
gene id: 243232:MJ_RS01500
uniprot id: Q57731
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

243232:MJ RS06805
gene id: 243232:MJ_RS06805
uniprot id: Q58668
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.
messages: The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit (By similarity).

243232:MJ RS07435
gene id: 243232:MJ_RS07435
uniprot id: Q58786
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli.

243232:MJ RS00180
gene id: 243232:MJ_RS00180
uniprot id: P54012
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

243232:MJ RS02785
gene id: 243232:MJ_RS02785
uniprot id: Q57946
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS07390
gene id: 243232:MJ_RS07390
uniprot id: Q58776
names: Caution
names: Cofactor
names: Domain
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: CarB is split into two genes in M.jannaschii (MJ1378 and MJ1381).
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Corresponds to the C-terminal section.

243232:MJ RS04465
gene id: 243232:MJ_RS04465
uniprot id: Q58245
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS06565
gene id: 243232:MJ_RS06565
uniprot id: Q58624
names: Cofactor
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

243232:MJ RS06040
gene id: 243232:MJ_RS06040
uniprot id: Q58531
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

243232:MJ RS05930
gene id: 243232:MJ_RS05930
uniprot id: Q58508
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

243232:MJ RS05765
gene id: 243232:MJ_RS05765
uniprot id: Q58477
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.

243232:MJ RS08830
gene id: 243232:MJ_RS08830
uniprot id: Q59054
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

243232:MJ RS06950
gene id: 243232:MJ_RS06950
uniprot id: Q58695
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.

243232:MJ RS00525
gene id: 243232:MJ_RS00525
uniprot id: Q57567
names: Cofactor
names: Similarity
messages: Belongs to the radical SAM superfamily.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

243232:MJ RS01470
gene id: 243232:MJ_RS01470
uniprot id: Q57725
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Dimer of large and small chains.

243232:MJ RS07420
gene id: 243232:MJ_RS07420
uniprot id: Q58783
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine. Is specific for SIH and inosine as it is unable to either hydrolyze SAH or synthesize SAH from adenosine and Hcy.
messages: Cytoplasm
messages: Exists both as a homotetramer and a homodimer, in a 4:1 ratio.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

243232:MJ RS03560
gene id: 243232:MJ_RS03560
uniprot id: Q58089
names: Similarity
messages: Belongs to the HypE family.

243232:MJ RS06415
gene id: 243232:MJ_RS06415
uniprot id: P54064
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

243232:MJ RS03585
gene id: 243232:MJ_RS03585
uniprot id: Q58094
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the transketolase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Could be the product of a pseudogene. Corresponds to the N-terminal of members of this family.

243232:MJ RS07415
gene id: 243232:MJ_RS07415
uniprot id: Q58782
names: Similarity
messages: Belongs to the LarC family.

243232:MJ RS04765
gene id: 243232:MJ_RS04765
uniprot id: Q58301
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

243232:MJ RS02460
gene id: 243232:MJ_RS02460
uniprot id: P54037
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

243232:MJ RS05800
gene id: 243232:MJ_RS05800
uniprot id: Q58483
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SsuE family. Isf subfamily.
messages: Binds 1 FMN per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Homodimer.
messages: Redox-active protein probably involved in electron transport.

243232:MJ RS07445
gene id: 243232:MJ_RS07445
uniprot id: Q58788
names: Similarity
names: Subcellular Location Annotation
messages: Membrane
messages: To M.jannaschii MJ1394 and A.fulgidus AF2028.

243232:MJ RS04670
gene id: 243232:MJ_RS04670
uniprot id: Q58282
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS05340
gene id: 243232:MJ_RS05340
uniprot id: Q58400
names: Similarity
messages: Belongs to the HypD family.

243232:MJ RS00005
gene id: 243232:MJ_RS00005
uniprot id: Q60317
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Cytoplasm
messages: Homodimer.

243232:MJ RS02175
gene id: 243232:MJ_RS02175
uniprot id: Q57854
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).

243232:MJ RS01605
gene id: 243232:MJ_RS01605
uniprot id: Q57752
names: Function
names: Similarity
messages: Belongs to the gamma-class carbonic anhydrase family.
messages: Probably reversibly hydrates carbon dioxide.

243232:MJ RS08900
gene id: 243232:MJ_RS08900
uniprot id: Q59069
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.

243232:MJ RS02065
gene id: 243232:MJ_RS02065
uniprot id: P54031
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit.

243232:MJ RS04795
gene id: 243232:MJ_RS04795
uniprot id: Q58307
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Membrane
messages: To M.voltae FlaF.

243232:MJ RS07245
gene id: 243232:MJ_RS07245
uniprot id: Q58749
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS03900
gene id: 243232:MJ_RS03900
uniprot id: Q58141
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SsuE family. Isf subfamily.
messages: Binds 1 FMN per subunit.
messages: Binds 1 [4Fe-4S] cluster.
messages: Homodimer.
messages: Redox-active protein probably involved in electron transport.

243232:MJ RS01945
gene id: 243232:MJ_RS01945
uniprot id: Q57815
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer (PubMed:10545127). Heterotetramer of two Top6A and two Top6B chains.
messages: Mg(2+) is directly coordinated by Glu-197 and Asp-249 as well as indirectly coordinated through 2 water molecules by Asp-251 (PubMed:10545127).
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

243232:MJ RS07985
gene id: 243232:MJ_RS07985
uniprot id: Q58889
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family.
messages: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).

243232:MJ RS07760
gene id: 243232:MJ_RS07760
uniprot id: Q58846
names: Similarity
messages: To M.thermoautotrophicum MTH1153.

243232:MJ RS05760
gene id: 243232:MJ_RS05760
uniprot id: Q58476
names: Similarity
messages: Belongs to the archaeal ATPase family.

243232:MJ RS03570
gene id: 243232:MJ_RS03570
uniprot id: Q58091
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS07400
gene id: 243232:MJ_RS07400
uniprot id: Q58778
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

243232:MJ RS08805
gene id: 243232:MJ_RS08805
uniprot id: Q59049
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

243232:MJ RS07000
gene id: 243232:MJ_RS07000
uniprot id: Q58705
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS08730
gene id: 243232:MJ_RS08730
uniprot id: Q59034
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

243232:MJ RS03720
gene id: 243232:MJ_RS03720
uniprot id: Q58117
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS06975
gene id: 243232:MJ_RS06975
uniprot id: Q58700
names: Function
messages: Putative toxin component of a putative type VII toxin-antitoxin (TA) system. Its cognate antitoxin might be MJ1305.

243232:MJ RS00900
gene id: 243232:MJ_RS00900
uniprot id: Q57635
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

243232:MJ RS04250
gene id: 243232:MJ_RS04250
uniprot id: P81233
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.jannaschii MJ1249.1, MJ0210.1 and MJ0785.1.

243232:MJ RS06320
gene id: 243232:MJ_RS06320
uniprot id: Q58584
names: Similarity
messages: Belongs to the DMRL synthase family.

243232:MJ RS06395
gene id: 243232:MJ_RS06395
uniprot id: Q58597
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:15240874). Also activates L-serine, but does not detectably transfer it to tRNA(Thr) (PubMed:15240874). Edits incorrectly charged L-seryl-tRNA(Thr) via its editing domain (PubMed:15240874). Has no activity on correctly acylated L-seryl-tRNA(Ser) or L-threonyl-tRNA(Thr) (PubMed:15240874). Deacylates correctly charged glycyl-tRNA(Gly), but not glycyl-tRNA(Gly)(2'-dA76) (the terminal 2'-OH of tRNA adenine 76 has been dehydroxylated) nor the 2'-fluoro tRNA derivative, strongly suggesting the editing function is tRNA catalyzed (PubMed:26113036).
messages: Cytoplasm
messages: Homodimer.
messages: Not inhibited by 1 uM borrelidin (BN); probably does not bind BN.
messages: The N-terminal domain (about residues 1-140) is an archaea-specific tRNA-editing domain (PubMed:15240874, PubMed:26113036) that has a highly similar structure to Dtd (D-aminoacyl-tRNA deacylase). Editing of incorrectly charged L-seryl-tRNA(Thr) by this domain is tRNA catalyzed (PubMed:26113036).

243232:MJ RS03335
gene id: 243232:MJ_RS03335
uniprot id: Q58047
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Cell membrane
messages: Potential transporter for phosphate.

243232:MJ RS04170
gene id: 243232:MJ_RS04170
uniprot id: P81312
names: Similarity
messages: To M.thermoautotrophicum MTH886.

243232:MJ RS09170
gene id: 243232:MJ_RS09170
uniprot id: Q60294
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0252 family.
messages: Cell membrane

243232:MJ RS03190
gene id: 243232:MJ_RS03190
uniprot id: Q58021
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MntA antitoxin family.
messages: Binds 2 Mg(2+) ions.
messages: Putative antitoxin component of a putative type VII toxin-antitoxin (TA) system. Its cognate toxin might be MJ0605, which it might AMPylate.

243232:MJ RS06205
gene id: 243232:MJ_RS06205
uniprot id: Q58561
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS02085
gene id: 243232:MJ_RS02085
uniprot id: Q57840
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

243232:MJ RS06485
gene id: 243232:MJ_RS06485
uniprot id: Q58609
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Cell membrane

243232:MJ RS00945
gene id: 243232:MJ_RS00945
uniprot id: P54018
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

243232:MJ RS08510
gene id: 243232:MJ_RS08510
uniprot id: Q58992
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. The use of tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate is 450-fold less efficient than that of H4MPT. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-allo-threonine and L-threo-beta-phenylserine.
messages: Cytoplasm
messages: Homodimer.

243232:MJ RS07460
gene id: 243232:MJ_RS07460
uniprot id: Q58791
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS05345
gene id: 243232:MJ_RS05345
uniprot id: Q58401
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

243232:MJ RS05105
gene id: 243232:MJ_RS05105
uniprot id: Q58357
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

243232:MJ RS08555
gene id: 243232:MJ_RS08555
uniprot id: Q59001
names: Caution
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Could lack activity as the potential ADP-glucose binding site Arg/Lys residue in position 15 is replaced by an Ser.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

243232:MJ RS02530
gene id: 243232:MJ_RS02530
uniprot id: Q60175
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

243232:MJ RS03695
gene id: 243232:MJ_RS03695
uniprot id: Q58113
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).

243232:MJ RS04570
gene id: 243232:MJ_RS04570
uniprot id: Q58262
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

243232:MJ RS06430
gene id: 243232:MJ_RS06430
uniprot id: Q58601
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
messages: Cytoplasm
messages: Feedback inhibited by histidine.

243232:MJ RS02980
gene id: 243232:MJ_RS02980
uniprot id: Q57985
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS00740
gene id: 243232:MJ_RS00740
uniprot id: Q57606
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MntA antitoxin family.
messages: Binds 2 Mg(2+) ions.
messages: Putative antitoxin component of a putative type VII toxin-antitoxin (TA) system. Its cognate toxin might be MF0142, which it might AMPylate.

243232:MJ RS08560
gene id: 243232:MJ_RS08560
uniprot id: Q59002
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

243232:MJ RS08365
gene id: 243232:MJ_RS08365
uniprot id: Q58963
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

243232:MJ RS01225
gene id: 243232:MJ_RS01225
uniprot id: Q60173
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

243232:MJ RS08405
gene id: 243232:MJ_RS08405
uniprot id: Q58970
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

243232:MJ RS03545
gene id: 243232:MJ_RS03545
uniprot id: P54055
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

243232:MJ RS08655
gene id: 243232:MJ_RS08655
uniprot id: Q59020
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

243232:MJ RS03235
gene id: 243232:MJ_RS03235
uniprot id: P81310
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS02405
gene id: 243232:MJ_RS02405
uniprot id: Q57898
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane

243232:MJ RS06655
gene id: 243232:MJ_RS06655
uniprot id: Q58642
names: Similarity
messages: To M.jannaschii MJ1244 and M.thermoautotrophicum MTH1110.

243232:MJ RS08325
gene id: 243232:MJ_RS08325
uniprot id: Q58955
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane

243232:MJ RS08490
gene id: 243232:MJ_RS08490
uniprot id: Q58988
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Homodimer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits (By similarity).
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

243232:MJ RS03885
gene id: 243232:MJ_RS03885
uniprot id: Q58138
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-5S] clusters per homodimer.
messages: Binds 3 [4Fe-4S] clusters per homodimer.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster is to be the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer.
messages: Homodimer.
messages: This protein lacks the conserved Cys in position 45; it is replaced by a Tyr. It is therefore possible that the D-cluster is either altered or missing in this protein, which may not form homodimers.

243232:MJ RS02990
gene id: 243232:MJ_RS02990
uniprot id: Q57987
names: Function
names: Similarity
messages: Belongs to the FeoA family.
messages: Might be involved in Fe(2+) ion uptake (By similarity).

243232:MJ RS05545
gene id: 243232:MJ_RS05545
uniprot id: Q58439
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Cell membrane
messages: Homopentamer (PubMed:23091000, PubMed:26051127). In the absence of Mg(2+), interactions between subunits are weakened, and dimers, trimers and tetramers can be observed in vitro (By similarity). Was initially proposed to be a homotetramer, based on the cross-linking studies (PubMed:15231793). This is in contradiction with current 3D-structures that clearly show it is a homopentamer (PubMed:23091000, PubMed:26051127).
messages: Inhibited by cation hexaammines.
messages: Mediates influx of magnesium ions (PubMed:9573171, PubMed:10748031). Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high (By similarity).
messages: The central ion permeation pathway is formed by the first transmembrane domain from each of the five subunits. Mg(2+) binding strengthens interactions between subunits and leads to the formation of a symmetrical homopentamer surrounding a closed ion permeation pathway (PubMed:23091000). Low cytoplasmic Mg(2+) concentrations trigger both a conformation change within each subunit and a loosening of the interactions between subunits. This results in an open ion conduction pathway. In addition, this results in a less symmetrical shape of the whole complex (PubMed:26051127).

243232:MJ RS04540
gene id: 243232:MJ_RS04540
uniprot id: Q58256
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Cytoplasm
messages: Is methylated on C5 of Arg-274 by the methyltransferase MJ0841. This post-translational methylation, despite being not essential in vivo, plays a role for the stability and structural integrity of MCR.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

243232:MJ RS06810
gene id: 243232:MJ_RS06810
uniprot id: Q58669
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

243232:MJ RS08935
gene id: 243232:MJ_RS08935
uniprot id: Q59076
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane

243232:MJ RS03955
gene id: 243232:MJ_RS03955
uniprot id: Q58152
names: Similarity
messages: To M.jannaschii MJ1511.

243232:MJ RS01110
gene id: 243232:MJ_RS01110
uniprot id: Q57665
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

243232:MJ RS05750
gene id: 243232:MJ_RS05750
uniprot id: Q58474
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the M.jannaschii MJ0023/MJ0349/MJ1072/MJ1074/MJ1107/MJECL16 family.
messages: Membrane

243232:MJ RS05100
gene id: 243232:MJ_RS05100
uniprot id: Q58356
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

243232:MJ RS06010
gene id: 243232:MJ_RS06010
uniprot id: Q58524
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

243232:MJ RS06425
gene id: 243232:MJ_RS06425
uniprot id: P54066
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

243232:MJ RS06235
gene id: 243232:MJ_RS06235
uniprot id: Q58566
names: Cofactor
messages: Binds 8 [4Fe-4S] clusters.

243232:MJ RS01805
gene id: 243232:MJ_RS01805
uniprot id: Q57789
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS03135
gene id: 243232:MJ_RS03135
uniprot id: Q58012
names: Function
messages: Probably involved in the biogenesis of the ribosome.

243232:MJ RS08375
gene id: 243232:MJ_RS08375
uniprot id: Q58965
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.thermoautotrophicum MTH1706.

243232:MJ RS08010
gene id: 243232:MJ_RS08010
uniprot id: Q58894
names: Function
messages: May be involved in control of expression of the type II restriction enzyme MjaV and/or its methyltransferase M.MjaV.

243232:MJ RS06680
gene id: 243232:MJ_RS06680
uniprot id: Q58646
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

243232:MJ RS02810
gene id: 243232:MJ_RS02810
uniprot id: Q57950
names: Similarity
messages: Belongs to the ZPR1 family.

243232:MJ RS06715
gene id: 243232:MJ_RS06715
uniprot id: Q58652
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

243232:MJ RS03160
gene id: 243232:MJ_RS03160
uniprot id: Q58015
names: Function
names: Similarity
messages: An alpha subtype methylase that recognizes the double-stranded sequence 5'-GATC-3', methylates A-2 on both strands, and protects the DNA from cleavage by the MjaIII endonuclease.
messages: Belongs to the N(4)/N(6)-methyltransferase family.

243232:MJ RS08410
gene id: 243232:MJ_RS08410
uniprot id: Q58971
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Cell membrane

243232:MJ RS06525
gene id: 243232:MJ_RS06525
uniprot id: Q58617
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the N(4)/N(6)-methyltransferase family.
messages: The subtype gamma methyltransferase (M) subunit of a type I restriction enzyme. The M and S subunits together form a methyltransferase (MTase) that methylates A-2 on the top and A-3 on the bottom strand of the sequence 5'-GAYN(5)GTAA-3'. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated. After locating a non-methylated recognition site, the enzyme complex serves as a molecular motor that translocates DNA in an ATP-dependent manner until a collision occurs that triggers cleavage.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.
messages: Type I restriction and modification enzymes are complex, multifunctional systems which require ATP, S-adenosyl methionine and Mg(2+) as cofactors and, in addition to their endonucleolytic and methylase activities, are potent DNA-dependent ATPases.

243232:MJ RS00430
gene id: 243232:MJ_RS00430
uniprot id: Q57551
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.

243232:MJ RS00930
gene id: 243232:MJ_RS00930
uniprot id: P54015
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

243232:MJ RS00745
gene id: 243232:MJ_RS00745
uniprot id: Q57607
names: Function
names: Similarity
messages: Belongs to the UPF0332 family.
messages: Putative toxin component of a putative type VII toxin-antitoxin (TA) system. Its cognate antitoxin might be MJ0141.

243232:MJ RS00990
gene id: 243232:MJ_RS00990
uniprot id: P54020
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

243232:MJ RS02765
gene id: 243232:MJ_RS02765
uniprot id: Q57942
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS05415
gene id: 243232:MJ_RS05415
uniprot id: Q58414
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

243232:MJ RS05310
gene id: 243232:MJ_RS05310
uniprot id: Q58394
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).

243232:MJ RS00125
gene id: 243232:MJ_RS00125
uniprot id: Q60335
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
messages: Cytoplasm

243232:MJ RS04830
gene id: 243232:MJ_RS04830
uniprot id: Q58314
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS05525
gene id: 243232:MJ_RS05525
uniprot id: Q58435
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

243232:MJ RS06385
gene id: 243232:MJ_RS06385
uniprot id: Q58595
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).

243232:MJ RS02310
gene id: 243232:MJ_RS02310
uniprot id: Q57880
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the methylation of the guanosine nucleotide at position 6 (m2G6) in tRNA(Cys).

243232:MJ RS04620
gene id: 243232:MJ_RS04620
uniprot id: Q58272
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Inhibited by 3,4-epoxy-3-methylbutyl diphosphate (EIPP).
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

243232:MJ RS08200
gene id: 243232:MJ_RS08200
uniprot id: Q58930
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS01935
gene id: 243232:MJ_RS01935
uniprot id: Q57813
names: Similarity
messages: Belongs to the 'phage' integrase family.

243232:MJ RS07865
gene id: 243232:MJ_RS07865
uniprot id: Q58866
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS03355
gene id: 243232:MJ_RS03355
uniprot id: Q58051
names: Cofactor
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

243232:MJ RS05975
gene id: 243232:MJ_RS05975
uniprot id: Q58517
names: Function
names: Miscellaneous
names: Subunit
messages: Binds GTP first, before binding AdoCbi-P.
messages: Guanylyltransferase that catalyzes the synthesis of adenosylcobinamide-GDP (AdoCbi-GDP) from adenosylcobinamide-phosphate (AdoCbi-P) and GTP. Is involved in adenosylcobalamin biosynthesis. Binds one GTP per dimer. Cannot use other NTPs or GDP. Does not display AdoCbi kinase activity. Is also able to catalyze the condensation of 2-phospho-L-lactate (LP) with GTP in vitro to form PPi and (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), but is much less efficient than CofC, the presumed enzyme catalyzing this reaction in vivo.
messages: Homodimer.

243232:MJ RS08195
gene id: 243232:MJ_RS08195
uniprot id: Q58929
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

243232:MJ RS04230
gene id: 243232:MJ_RS04230
uniprot id: P81313
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS07055
gene id: 243232:MJ_RS07055
uniprot id: Q58716
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB4 (By similarity).

243232:MJ RS06650
gene id: 243232:MJ_RS06650
uniprot id: Q58641
names: Similarity
messages: To M.jannaschii MJ1245 and M.thermoautotrophicum MTH1110.

243232:MJ RS08815
gene id: 243232:MJ_RS08815
uniprot id: Q59051
names: Similarity
messages: Belongs to the peptidase U32 family.

243232:MJ RS04695
gene id: 243232:MJ_RS04695
uniprot id: Q58288
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS00625
gene id: 243232:MJ_RS00625
uniprot id: Q57585
names: Similarity
messages: Belongs to the ABC transporter superfamily.

243232:MJ RS02665
gene id: 243232:MJ_RS02665
uniprot id: Q57928
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS02435
gene id: 243232:MJ_RS02435
uniprot id: P54034
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

243232:MJ RS00650
gene id: 243232:MJ_RS00650
uniprot id: Q57590
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MntA antitoxin family.
messages: Binds 2 Mg(2+) ions.
messages: Probable antitoxin component of a putative type VII toxin-antitoxin (TA) system. Neutralizes cognate toxic MJ0125 by di-AMPylation.
messages: Probably forms a complex with cognate toxin MJ0125.

243232:MJ RS07370
gene id: 243232:MJ_RS07370
uniprot id: Q58773
names: Caution
names: Cofactor
names: Domain
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: CarB is split into two genes in M.jannaschii (MJ1378 and MJ1381).
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Corresponds to the N-terminal section.

243232:MJ RS06390
gene id: 243232:MJ_RS06390
uniprot id: Q58596
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily.
messages: Cell membrane

243232:MJ RS07060
gene id: 243232:MJ_RS07060
uniprot id: Q58717
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Induction
names: Similarity
messages: Also liganded by DNA (PubMed:28319084).
messages: An endodeoxyribonuclease that may play a role in defense against invading genetic elements. Uses short DNA sequences as guides to bind complementary target strands, resulting in slicing of the target DNA (PubMed:24442234, PubMed:27741323, PubMed:28319081, PubMed:28319084). Also has guide-independent activity on target DNA (PubMed:28319081). Probably a first round of guide-independent activity on an invading plasmid or virus would generate guide DNAs for subsequent, more efficient, guide-dependent degradation of invading nucleic acids (PubMed:28319081). Endonucleolytically cleaves DNA in short dsDNA (the guide DNA indicates where to cleave on the target DNA) (PubMed:24442234, PubMed:27741323, PubMed:28319081, PubMed:28319084). Efficient guide-dependent target DNA cleavage requires a minimal length of 15 bp and is maximal at 19 bp (PubMed:28319081). Prefers guide DNA with 5'-phosphorylated purines and 3'-pyrimidines; changing these bases alters the cleavage activity and patterns (PubMed:28319084). Has no activity on substrate with a mismatch at positions 10 and 11, ssDNA or RNA, nor on DNA-RNA hybrids (PubMed:24442234). Digests longer (750 bp) dsDNA as well as circular plasmid and naked genomic DNA, but not chromatin, in a guide DNA-independent manner (PubMed:28319081). Addition of endogenous histone A3 protects DNA from cleavage, while cleavage is insensitive to methylation (PubMed:28319081). When plasmid encoding active or mutated protein (Ala-541) is transformed into Sulfolobus acidocaldarius about 25-fold fewer transformants are found with active protein; reduced levels of plasmid are found in wild-type transformed cells. While S.acidocaldarius grows at a similar temperature to M.jannaschii (70 to 80 degrees Celsius) it has very different histone-like proteins, which presumably do not protect against MjAgo (PubMed:28319081). Binds ssDNA, dsDNA and DNA-RNA hybrids; binding is most efficient with dsDNA (PubMed:24442234).
messages: Belongs to the argonaute family. Long pAgo subfamily.
messages: Constitutively expressed (at protein level) (PubMed:28319081).
messages: DNA cleavage is inhibited by EDTA.
messages: Has 4 structurally distinct domains; N-terminal, PAZ (binds the 3'-end of guide DNA), Mid (binds the phosphorylated 5'-end of guide DNA) and PIWI (binds near the 5'-end of guide DNA) arranged in a bilobal manner (PubMed:28319084). Upon binding of guide DNA the PAZ and Mid domains separate, opening a channel probably for target DNA-binding; a smaller channel also opens between the N-terminal and PIWI domains (PubMed:28319084). The N-terminal and PAZ domains undergo further major rearrangement when the binary Ago-guide DNA complex binds target DNA; the PAZ domain binds the 3'-end of guide DNA in the absence of target, upon ternary complex formation it is probably the N-terminal domain that binds that end of the dsDNA (PubMed:24442234).

243232:MJ RS07160
gene id: 243232:MJ_RS07160
uniprot id: Q58735
names: Similarity
messages: To M.thermoautotrophicum MTH765.

243232:MJ RS09785
gene id: 243232:MJ_RS09785
uniprot id: Q58689
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS06170
gene id: 243232:MJ_RS06170
uniprot id: P81316
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To A.fulgidus AF1754.

243232:MJ RS07395
gene id: 243232:MJ_RS07395
uniprot id: Q58777
names: Similarity
messages: Belongs to the UPF0310 family.

243232:MJ RS07365
gene id: 243232:MJ_RS07365
uniprot id: Q58772
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

243232:MJ RS05900
gene id: 243232:MJ_RS05900
uniprot id: Q58502
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.
messages: Homotrimer.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

243232:MJ RS03895
gene id: 243232:MJ_RS03895
uniprot id: Q58140
names: Similarity
messages: To M.jannaschii MJ0208.

243232:MJ RS02515
gene id: 243232:MJ_RS02515
uniprot id: P54046
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

243232:MJ RS06195
gene id: 243232:MJ_RS06195
uniprot id: Q58559
names: Function
names: Subunit
messages: Monomer. Binds to single-stranded DNA sequences.
messages: Probably plays an essential for replication of the chromosome, DNA recombination and repair (By similarity). Binds approximately 20 nucleotides.

243232:MJ RS02455
gene id: 243232:MJ_RS02455
uniprot id: P54036
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

243232:MJ RS05895
gene id: 243232:MJ_RS05895
uniprot id: Q58501
names: Function
names: Similarity
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP-GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1-P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcNAc and pyrophosphate. Also catalyzes the reverse reaction, i.e. the cleavage of UDP-GlcNAc with pyrophosphate to form UTP and GlcNAc-1-P. To a lesser extent, is also able to use dUTP or dTTP as the nucleotide substrate, but not CTP, ATP or GTP.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

243232:MJ RS01540
gene id: 243232:MJ_RS01540
uniprot id: Q57739
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

243232:MJ RS01525
gene id: 243232:MJ_RS01525
uniprot id: Q57736
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS02995
gene id: 243232:MJ_RS02995
uniprot id: Q57988
names: Similarity
messages: Belongs to the DtxR/MntR family.

243232:MJ RS08860
gene id: 243232:MJ_RS08860
uniprot id: Q59060
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Activated by cyclic oligoadenylate (cOA) to endonucleolytically degrade linear RNA; when cOA levels decrease the RNase activity of Csx1 is abrogated.
messages: Belongs to the CRISPR-associated Csx1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities.
messages: Encoded in a type III-A CRISPR locus.
messages: Homodimer.
messages: The RNase activity is stimulated by cOA.

243232:MJ RS07750
gene id: 243232:MJ_RS07750
uniprot id: Q58844
names: Function
names: Similarity
messages: A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-GGNCC-3'; the cleavage site is unknown.
messages: Belongs to the TdeIII type II restriction endonuclease family.

243232:MJ RS09070
gene id: 243232:MJ_RS09070
uniprot id: Q60280
names: Similarity
messages: To M.jannaschii MJ0215.

243232:MJ RS04515
gene id: 243232:MJ_RS04515
uniprot id: Q58251
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MCR alpha subunit C-methyltransferase family.
messages: Binds at least 1 [4Fe-4S] cluster. This cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM methyltransferase that is responsible for the C(5)-methylation of 'Arg-274' of the methyl-coenzyme M reductase (MCR) subunit alpha McrA. This post-translational methylation, despite being not essential in vivo, plays a role for the stability and structural integrity of MCR.

243232:MJ RS00760
gene id: 243232:MJ_RS00760
uniprot id: Q57609
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.
messages: Homotrimer.
messages: This enzyme couples pyrophosphate hydrolysis to the guanine ring-opening reaction. GTP cyclohydrolase and pyrophosphate phosphoydrolase activities probably occur at independent sites.

243232:MJ RS08170
gene id: 243232:MJ_RS08170
uniprot id: Q58924
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

243232:MJ RS07685
gene id: 243232:MJ_RS07685
uniprot id: Q58831
names: Similarity
messages: To M.thermoautotrophicum MTH1236.

243232:MJ RS05440
gene id: 243232:MJ_RS05440
uniprot id: Q58418
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

243232:MJ RS01095
gene id: 243232:MJ_RS01095
uniprot id: Q57663
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

243232:MJ RS03195
gene id: 243232:MJ_RS03195
uniprot id: Q58022
names: Function
names: Similarity
messages: Belongs to the UPF0332 family.
messages: Putative toxin component of a putative type VII toxin-antitoxin (TA) system. Its cognate antitoxin might be MJ0604.

243232:MJ RS00290
gene id: 243232:MJ_RS00290
uniprot id: Q60362
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: This is a Na(+)/H(+) antiporter. Can also transport lithium.

243232:MJ RS03465
gene id: 243232:MJ_RS03465
uniprot id: P54054
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

243232:MJ RS01325
gene id: 243232:MJ_RS01325
uniprot id: Q57700
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

243232:MJ RS09105
gene id: 243232:MJ_RS09105
uniprot id: Q60286
names: Similarity
messages: To M.jannaschii MJECS06.

243232:MJ RS03845
gene id: 243232:MJ_RS03845
uniprot id: Q58130
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate, which decarboxylates to 4-methyl-2-oxopentanoate (2-oxoisocaproate). Also catalyzes the oxidative decarboxylation of 3-methylmalate to 2-oxobutyrate, and that of D-malate to pyruvate. Cannot use NADP(+) instead of NAD(+). Cannot catalyze the oxidation of L-malate, L-tartrate, D-tartrate, DL-isocitrate, or DL-lactate.
messages: Cytoplasm
messages: Homotetramer.

243232:MJ RS05630
gene id: 243232:MJ_RS05630
uniprot id: Q58450
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

243232:MJ RS00915
gene id: 243232:MJ_RS00915
uniprot id: Q57638
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

243232:MJ RS04435
gene id: 243232:MJ_RS04435
uniprot id: Q58241
names: Similarity
messages: To M.jannaschii MJ0977.

243232:MJ RS04900
gene id: 243232:MJ_RS04900
uniprot id: P0CW37
names: Function
messages: Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC1 (Potential).

243232:MJ RS00570
gene id: 243232:MJ_RS00570
uniprot id: Q57576
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

243232:MJ RS02260
gene id: 243232:MJ_RS02260
uniprot id: Q57871
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).
messages: Homotetramer; probably dimer of dimers.

243232:MJ RS04405
gene id: 243232:MJ_RS04405
uniprot id: Q58234
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

243232:MJ RS06900
gene id: 243232:MJ_RS06900
uniprot id: Q58686
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS05350
gene id: 243232:MJ_RS05350
uniprot id: Q58402
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS04220
gene id: 243232:MJ_RS04220
uniprot id: Q58201
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

243232:MJ RS03820
gene id: 243232:MJ_RS03820
uniprot id: Q58125
names: Similarity
messages: Belongs to the HMD family.

243232:MJ RS01960
gene id: 243232:MJ_RS01960
uniprot id: Q57818
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt5 family.
messages: Composed of only a NusG N-terminal (NGN) domain and a KOW domain, similar to bacterial NusG. The NGN domain is the effector domain of the complex that mediates the interaction with RNAP and is essential for elongation activity.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP). Forms a homodimer in solution.
messages: Stimulates transcription elongation.

243232:MJ RS03685
gene id: 243232:MJ_RS03685
uniprot id: Q58111
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell membrane

243232:MJ RS05905
gene id: 243232:MJ_RS05905
uniprot id: Q58503
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RelE toxin family.
messages: Forms heterodimers with RelB3 and possibly a heterotetramer RelE3-RelB3(2)-RelE3 from 2 heterodimers. The heterotetramer is probably not very stable in solution.
messages: Toxic component of a type II toxin-antitoxin (TA) system. Has RNase activity (By similarity). Is very toxic upon expression in E.coli. Its toxic activity is probably neutralized by the cognate antitoxin RelB3.

243232:MJ RS06750
gene id: 243232:MJ_RS06750
uniprot id: Q58657
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

243232:MJ RS05530
gene id: 243232:MJ_RS05530
uniprot id: Q58436
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

243232:MJ RS02820
gene id: 243232:MJ_RS02820
uniprot id: Q57952
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

243232:MJ RS06005
gene id: 243232:MJ_RS06005
uniprot id: Q58523
names: Similarity
messages: To M.jannaschii MJ0638 and MJ1252 and M.tuberculosis Rv2003c.

243232:MJ RS08075
gene id: 243232:MJ_RS08075
uniprot id: Q58907
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Binds two Mg(2+) per subunit.
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain (By similarity).
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity).
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

243232:MJ RS03255
gene id: 243232:MJ_RS03255
uniprot id: Q58032
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

243232:MJ RS02045
gene id: 243232:MJ_RS02045
uniprot id: Q57834
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

243232:MJ RS04095
gene id: 243232:MJ_RS04095
uniprot id: Q58178
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. Cannot use F420-2 as substrate to add more glutamates. Exhibits maximum activity with GTP, compared with UTP (66%) and dGTP (25%); with ATP, only F420-1 is observed as the product; CTP and TTP support no activity.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

243232:MJ RS07380
gene id: 243232:MJ_RS07380
uniprot id: Q58774
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MntA antitoxin family.
messages: Binds 2 Mg(2+) ions.
messages: Probable antitoxin component of a putative type VII toxin-antitoxin (TA) system. Neutralizes cognate toxic MJ1380 by di-AMPylation.
messages: Probably forms a complex with cognate toxin MJ1380.

243232:MJ RS01590
gene id: 243232:MJ_RS01590
uniprot id: Q57749
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily.
messages: Catalyzes the condensation of 6-hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPP) with 4-(beta-D-ribofuranosyl)-aminobenzene-5'-phosphate (beta-RFA-P) to form 7,8-dihydropterin-6-methyl-4-(beta-D-ribofuranosyl)-aminobenzene-5'-phosphate, a precursor in the biosynthesis of 5,6,7,8-tetrahydromethanopterin (H4MPT). To a lesser extent, is able to condense beta-RFA-P with another arylamine, 1-(4-aminophenyl)-1-deoxy-D-ribitol (APDR), to form 7,8-dihydropterin-6-methyl-1-(4-aminophenyl)-1-deoxy-D-ribitol. Dephosphorylated beta-RFA-P is not a substrate.

243232:MJ RS00775
gene id: 243232:MJ_RS00775
uniprot id: Q57612
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

243232:MJ RS00720
gene id: 243232:MJ_RS00720
uniprot id: Q57603
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family.
messages: Cell membrane
messages: Homotetramer.
messages: Inhibited by barium.
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids.
messages: Voltage-gated potassium-selective channel opened by hyperpolarization.

243232:MJ RS09235
gene id: 243232:MJ_RS09235
uniprot id: Q60304
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS04770
gene id: 243232:MJ_RS04770
uniprot id: Q58302
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

243232:MJ RS06690
gene id: 243232:MJ_RS06690
uniprot id: Q58647
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

243232:MJ RS07020
gene id: 243232:MJ_RS07020
uniprot id: Q58709
names: Similarity
messages: To M.thermoautotrophicum MTH1421.

243232:MJ RS02735
gene id: 243232:MJ_RS02735
uniprot id: Q57936
names: Cofactor
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.

243232:MJ RS06760
gene id: 243232:MJ_RS06760
uniprot id: Q58659
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

243232:MJ RS06990
gene id: 243232:MJ_RS06990
uniprot id: Q58703
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS06220
gene id: 243232:MJ_RS06220
uniprot id: Q58563
names: Similarity
messages: Belongs to the UPF0173 family.

243232:MJ RS01430
gene id: 243232:MJ_RS01430
uniprot id: Q57719
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS02215
gene id: 243232:MJ_RS02215
uniprot id: Q57862
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS07745
gene id: 243232:MJ_RS07745
uniprot id: Q58843
names: Function
names: Similarity
messages: An alpha subtype methylase that recognizes the double-stranded sequence 5'-GGNCC-3', methylates C-5 on both strands, and protects the DNA from cleavage by the MjaII endonuclease.
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

243232:MJ RS04395
gene id: 243232:MJ_RS04395
uniprot id: Q58232
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mj S-layer protein family.
messages: S-layer
messages: S-layer protein. The S-layer is a paracrystalline mono-layered assembly of proteins which coat the surface of the cell.

243232:MJ RS03270
gene id: 243232:MJ_RS03270
uniprot id: Q58035
names: Similarity
messages: Belongs to the UPF0235 family.

243232:MJ RS05595
gene id: 243232:MJ_RS05595
uniprot id: Q58446
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

243232:MJ RS04065
gene id: 243232:MJ_RS04065
uniprot id: Q58172
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Cell membrane

243232:MJ RS07775
gene id: 243232:MJ_RS07775
uniprot id: Q58849
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

243232:MJ RS08165
gene id: 243232:MJ_RS08165
uniprot id: Q58923
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

243232:MJ RS07135
gene id: 243232:MJ_RS07135
uniprot id: Q58730
names: Similarity
messages: Belongs to the UDPGP type 2 family.

243232:MJ RS03620
gene id: 243232:MJ_RS03620
uniprot id: Q58101
names: Similarity
messages: Belongs to the UPF0146 family.

243232:MJ RS03920
gene id: 243232:MJ_RS03920
uniprot id: Q58145
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule (By similarity).

243232:MJ RS05190
gene id: 243232:MJ_RS05190
uniprot id: Q58373
names: Similarity
messages: Belongs to the HyuB family.

243232:MJ RS06800
gene id: 243232:MJ_RS06800
uniprot id: Q58667
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Component of a hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate, and even the non-physiological cis-homo(4)-aconitate with similar efficiency. These reactions are part of the biosynthesis pathway of coenzyme B. Can also catalyze the hydration of maleate to (R)-malate, and that of cis-aconitate. Cannot catalyze the hydration of citraconate and the dehydration of (S)-homocitrate, citramalate, 2-isopropylmalate, 3-isopropylmalate, citrate or threo-DL-isocitrate.
messages: Heterotetramer of 2 HacA and 2 HacB proteins. Cannot form a complex with LeuC.

243232:MJ RS03850
gene id: 243232:MJ_RS03850
uniprot id: Q58131
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

243232:MJ RS07280
gene id: 243232:MJ_RS07280
uniprot id: Q58756
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS04630
gene id: 243232:MJ_RS04630
uniprot id: Q58274
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrC family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

243232:MJ RS00910
gene id: 243232:MJ_RS00910
uniprot id: Q57637
names: Function
names: Similarity
messages: Belongs to the Tfx family.
messages: Putative transcriptional regulator.

243232:MJ RS01350
gene id: 243232:MJ_RS01350
uniprot id: P58416
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Heterododecamer composed of 6 subunits alpha and 6 subunits beta.
messages: Inhibited by oxygen when heated in air at 80 degrees Celsius. The enzyme is reactivated by addition of dithionite.
messages: Involved in the biosynthesis of the coenzyme M (2-mercaptoethanesulfonic acid). Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde.
messages: The sequence corresponding to this entry was originally entered in Swiss-Prot as AC Q57704 in November 1997 and was deleted in July 1999 because TIGR removed the CDS for that ORF. We have recreated it because of the evidence (PubMed:10940029) that it really exists.

243232:MJ RS07965
gene id: 243232:MJ_RS07965
uniprot id: Q58885
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

243232:MJ RS08140
gene id: 243232:MJ_RS08140
uniprot id: Q58918
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

243232:MJ RS01255
gene id: 243232:MJ_RS01255
uniprot id: Q57689
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

243232:MJ RS07075
gene id: 243232:MJ_RS07075
uniprot id: Q58720
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MobB family.
messages: Binds 1 [4Fe-4S] cluster.
messages: GTP-binding protein that is not required for the biosynthesis of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor, and not necessary for the formation of active molybdoenzymes using this form of molybdenum cofactor. May act as an adapter protein to achieve the efficient biosynthesis and utilization of MGD. Displays a weak intrinsic GTPase activity (By similarity).

243232:MJ RS07655
gene id: 243232:MJ_RS07655
uniprot id: Q58825
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

243232:MJ RS03995
gene id: 243232:MJ_RS03995
uniprot id: Q58160
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS07200
gene id: 243232:MJ_RS07200
uniprot id: Q58742
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

243232:MJ RS00090
gene id: 243232:MJ_RS00090
uniprot id: Q60324
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS01410
gene id: 243232:MJ_RS01410
uniprot id: Q57716
names: Cofactor
names: Subunit
messages: Binds 2 [4Fe-4S] clusters.
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

243232:MJ RS07330
gene id: 243232:MJ_RS07330
uniprot id: Q58765
names: Similarity
messages: Belongs to the UPF0285 family.

243232:MJ RS06710
gene id: 243232:MJ_RS06710
uniprot id: Q58651
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS05420
gene id: 243232:MJ_RS05420
uniprot id: Q58415
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

243232:MJ RS00765
gene id: 243232:MJ_RS00765
uniprot id: Q57610
names: Cofactor
messages: Binds 2 [4Fe-4S] clusters.

243232:MJ RS05475
gene id: 243232:MJ_RS05475
uniprot id: Q58425
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

243232:MJ RS00355
gene id: 243232:MJ_RS00355
uniprot id: Q60373
names: Function
messages: Antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is RelE1 (Potential).

243232:MJ RS06705
gene id: 243232:MJ_RS06705
uniprot id: Q58650
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

243232:MJ RS00200
gene id: 243232:MJ_RS00200
uniprot id: P54013
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

243232:MJ RS02195
gene id: 243232:MJ_RS02195
uniprot id: Q57858
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS09150
gene id: 243232:MJ_RS09150
uniprot id: Q60257
names: Similarity
messages: Belongs to the UPF0310 family.

243232:MJ RS01695
gene id: 243232:MJ_RS01695
uniprot id: P54029
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

243232:MJ RS00055
gene id: 243232:MJ_RS00055
uniprot id: Q60326
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

243232:MJ RS05885
gene id: 243232:MJ_RS05885
uniprot id: Q58499
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).
messages: Homohexamer. Trimer of dimers.

243232:MJ RS01985
gene id: 243232:MJ_RS01985
uniprot id: Q57822
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: Binds 1 [4Fe-4S] cluster per subunit. It may be important for protein stability, since mutation of the Cys that bind the cofactor leads to a colorless, insoluble protein.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This protein may be a 5' to 3' ssDNA exonuclease.
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity. Can also utilise Cu(2+).

243232:MJ RS01000
gene id: 243232:MJ_RS01000
uniprot id: Q57648
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex (By similarity). Interacts with Rpo12. Forms an Rpo3-Rpo10-Rpo11-Rpo12 complex upon coexpression (PubMed:11058130).

243232:MJ RS02845
gene id: 243232:MJ_RS02845
uniprot id: Q57957
names: Subunit
messages: Heterotetramer of the KorA, KorB, KorC and KorD subunits.

243232:MJ RS07700
gene id: 243232:MJ_RS07700
uniprot id: Q58834
names: Similarity
messages: Belongs to the thermonuclease family.

243232:MJ RS07770
gene id: 243232:MJ_RS07770
uniprot id: Q58848
names: Similarity
messages: To M.thermoautotrophicum MTH863.

243232:MJ RS02070
gene id: 243232:MJ_RS02070
uniprot id: P54032
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

243232:MJ RS05620
gene id: 243232:MJ_RS05620
uniprot id: Q58448
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
messages: Cytoplasm

243232:MJ RS03710
gene id: 243232:MJ_RS03710
uniprot id: Q58115
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS01140
gene id: 243232:MJ_RS01140
uniprot id: Q57671
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

243232:MJ RS05555
gene id: 243232:MJ_RS05555
uniprot id: Q58441
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

243232:MJ RS08005
gene id: 243232:MJ_RS08005
uniprot id: Q58893
names: Function
names: Similarity
messages: A beta subtype methylase that recognizes the double-stranded sequence 5'-GTAC-3', methylates C-4 on both strands, and protects the DNA from cleavage by the MjaV endonuclease.
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

243232:MJ RS02230
gene id: 243232:MJ_RS02230
uniprot id: Q57865
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

243232:MJ RS06135
gene id: 243232:MJ_RS06135
uniprot id: Q58549
names: Cofactor
names: Similarity
messages: Belongs to the Nudix hydrolase family. NudF subfamily.
messages: Binds 3 Mg(2+) ions per subunit.

243232:MJ RS02080
gene id: 243232:MJ_RS02080
uniprot id: Q57839
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

243232:MJ RS00220
gene id: 243232:MJ_RS00220
uniprot id: Q60352
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. Has no activity with farnesyl phosphate.
messages: Homodimer.

243232:MJ RS03200
gene id: 243232:MJ_RS03200
uniprot id: Q58023
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS01915
gene id: 243232:MJ_RS01915
uniprot id: Q57809
names: Similarity
messages: Belongs to the MCM family.

243232:MJ RS06070
gene id: 243232:MJ_RS06070
uniprot id: Q58537
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS08870
gene id: 243232:MJ_RS08870
uniprot id: Q59062
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated Csm4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities.
messages: Encoded in a type III-A CRISPR locus.
messages: Part of the Csm effector complex that includes Cas10, Csm2, Csm3, Csm4 and Csm5 (By similarity). Stable Cas10/Csm1-Csm4, Csm3-Csm4 (which crystallizes as 2 heterodimers) and Cas10-Csm1-Csm3-Csm4 subcomplexes can be isolated (PubMed:25451598).
messages: The subunit probably binds to the 5' handle of the crRNA, helping in discrimination between self- and non-self (Probable). The Csm3-Csm4 complex binds both crRNA and a non-specific RNA; Csm4 alone also binds RNA (PubMed:25451598).

243232:MJ RS05465
gene id: 243232:MJ_RS05465
uniprot id: Q58423
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS02670
gene id: 243232:MJ_RS02670
uniprot id: Q57929
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).

243232:MJ RS00105
gene id: 243232:MJ_RS00105
uniprot id: Q60332
names: Cofactor
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

243232:MJ RS03660
gene id: 243232:MJ_RS03660
uniprot id: Q58106
names: Similarity
messages: To M.jannaschii MJ0803.

243232:MJ RS08000
gene id: 243232:MJ_RS08000
uniprot id: Q58892
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.

243232:MJ RS08385
gene id: 243232:MJ_RS08385
uniprot id: Q58967
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).

243232:MJ RS00645
gene id: 243232:MJ_RS00645
uniprot id: Q57589
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the HepT RNase toxin family.
messages: Homodimer, probably forms a complex with cognate antitoxin MJ0126.
messages: Modified by cognate antitoxin MJ0126; probably at least 2 successive AMPylation events occur on Tyr-83.
messages: Probable toxic component of a putative type VII toxin-antitoxin (TA) system, probably an RNase. Probably neutralized by cognate antitoxin MJ0126. Neutralization may be due to AMPylation by MJ0126.

243232:MJ RS08125
gene id: 243232:MJ_RS08125
uniprot id: Q58915
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. ChlP subfamily.

243232:MJ RS01260
gene id: 243232:MJ_RS01260
uniprot id: Q57690
names: Function
names: Subunit
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).

243232:MJ RS02410
gene id: 243232:MJ_RS02410
uniprot id: Q57899
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.

243232:MJ RS01660
gene id: 243232:MJ_RS01660
uniprot id: Q57763
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Competitively inhibited by methylglyoxal bis-guanylhydrazone. Inactivated by treatment with the imine reductant NaCNBH(3) only in the presence of substrate.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

243232:MJ RS04710
gene id: 243232:MJ_RS04710
uniprot id: Q58291
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

243232:MJ RS08485
gene id: 243232:MJ_RS08485
uniprot id: Q58987
names: Similarity
messages: Belongs to the SAICAR synthetase family.

243232:MJ RS04130
gene id: 243232:MJ_RS04130
uniprot id: Q58185
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit. Mn(2+) and Zn(2+) can be used to a lesser extent, but not at a relevant physiological concentration.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. It is also able to utilize a variety of GTP analogs as substrates, including GDP, beta,gamma-methylene-GTP and GTP-[gamma-thio].
messages: Homodimer.
messages: Inhibited by GTP concentrations greater than 0.3 mM and by 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone 5'-phosphate (fapyGMP). Partial inhibition is observed when 2 mM GMP, dGTP, or 7-methyl-GTP was included along with 2 mM GTP.
messages: MptA is the archetype of a new class of GTP cyclohydrolases that catalyzes a series of reactions most similar to that seen with GTPCHI but unique in that the cyclic phosphate is the product.

243232:MJ RS01230
gene id: 243232:MJ_RS01230
uniprot id: Q57685
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.jannaschii MJ1189.

243232:MJ RS03275
gene id: 243232:MJ_RS03275
uniprot id: Q58036
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the radical SAM superfamily.
messages: Binds 2 S-adenosyl-L-methionine per subunit.
messages: Binds 2 [4Fe-4S] clusters. The clusters are coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Is responsible for the addition of methyl groups at C-7 and C-9 of the pterin ring during methanopterin (MPT) biosynthesis. Catalyzes methylation of 7,8-dihydro-6-hydroxymethylpterin, likely using methylenetetrahydromethanopterin as a methyl group donor, via a radical-based mechanism.
messages: The most N-terminal iron-sulfur cluster is involved in C-9 methylation, while the second cluster is required for C-7 methylation of the pterin ring. Moreover, C-7 methylation occurs before C-9 methylation.

243232:MJ RS00505
gene id: 243232:MJ_RS00505
uniprot id: Q57565
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

243232:MJ RS04430
gene id: 243232:MJ_RS04430
uniprot id: Q58240
names: Similarity
messages: Belongs to the LarE family.

243232:MJ RS00700
gene id: 243232:MJ_RS00700
uniprot id: Q57599
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

243232:MJ RS02565
gene id: 243232:MJ_RS02565
uniprot id: Q57909
names: Cofactor
names: Similarity
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues.

243232:MJ RS08885
gene id: 243232:MJ_RS08885
uniprot id: Q59066
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities.
messages: Encoded in a type III-A CRISPR locus.
messages: Part of the Csm effector complex, that includes Cas10/Csm1, Csm2, Csm3, Csm4, Csm5 and mature crRNA (By similarity). Stable Cas10/Csm1-Csm4 and Cas10-Csm1-Csm3-Csm4 subcomplexes can be isolated; Cas10 and Csm3 probably do not directly interact (PubMed:25451598).
messages: The N-terminal HD domain has ssDNase activity. The C-terminal GGDEF domain has the cOA synthesis activity.
messages: This subunit is a single-strand-specific deoxyribonuclease (ssDNase) which digests both linear and circular ssDNA; it has both exo- and endonuclease activity.
messages: When associated with the ternary Csm effector complex (the crRNA, Cas proteins and a cognate target ssRNA) synthesizes cyclic oligoadenylates (cOA) from ATP. cOAs are second messengers that stimulate the ssRNase activity of Csx1, inducing an antiviral state important for defense against invading nucleic acids.
messages: ssDNase activity is stimulated in the ternary Csm effector complex; binding of cognate target RNA activates the ssDNase, as the target RNA is degraded ssDNA activity decreases.

243232:MJ RS00495
gene id: 243232:MJ_RS00495
uniprot id: Q57563
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] cluster.
messages: May form a complex with MJ0100.
messages: Required for O-acetylhomoserine sulfhydrylase (OAHS)-independent homocysteine (Hcy) biosynthesis. Together with MJ0100, catalyzes the condensation of sulfide with aspartate semialdehyde to generate homocysteine. May be involved in the reduction of the disulfide formed in MJ0100.

243232:MJ RS08345
gene id: 243232:MJ_RS08345
uniprot id: Q58959
names: Similarity
messages: Belongs to the UPF0201 family.

243232:MJ RS02625
gene id: 243232:MJ_RS02625
uniprot id: Q57920
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

243232:MJ RS04200
gene id: 243232:MJ_RS04200
uniprot id: Q58197
names: Similarity
messages: To M.thermoautotrophicum MTH1137.

243232:MJ RS01990
gene id: 243232:MJ_RS01990
uniprot id: Q57823
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

243232:MJ RS07725
gene id: 243232:MJ_RS07725
uniprot id: Q58839
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

243232:MJ RS02970
gene id: 243232:MJ_RS02970
uniprot id: Q57983
names: Function
names: Similarity
messages: A putative methylase that may protect DNA from cleavage by an unknown endonuclease.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

243232:MJ RS04505
gene id: 243232:MJ_RS04505
uniprot id: Q58249
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).

243232:MJ RS03670
gene id: 243232:MJ_RS03670
uniprot id: Q58108
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

243232:MJ RS07905
gene id: 243232:MJ_RS07905
uniprot id: Q58874
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Cytoplasm

243232:MJ RS00425
gene id: 243232:MJ_RS00425
uniprot id: Q57550
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS03510
gene id: 243232:MJ_RS03510
uniprot id: Q58080
names: Similarity
messages: Belongs to the MoeA family.

243232:MJ RS04575
gene id: 243232:MJ_RS04575
uniprot id: Q58263
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

243232:MJ RS07500
gene id: 243232:MJ_RS07500
uniprot id: Q58798
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS08525
gene id: 243232:MJ_RS08525
uniprot id: Q58995
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

243232:MJ RS06100
gene id: 243232:MJ_RS06100
uniprot id: Q58543
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell membrane
messages: Large-conductance mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Selective for cations. Rectifies with voltage.

243232:MJ RS01955
gene id: 243232:MJ_RS01955
uniprot id: Q57817
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

243232:MJ RS05840
gene id: 243232:MJ_RS05840
uniprot id: Q58491
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

243232:MJ RS00310
gene id: 243232:MJ_RS00310
uniprot id: Q60368
names: Cofactor
messages: Binds 2 [4Fe-4S] clusters.

243232:MJ RS04135
gene id: 243232:MJ_RS04135
uniprot id: Q58186
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS04555
gene id: 243232:MJ_RS04555
uniprot id: Q58259
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

243232:MJ RS01690
gene id: 243232:MJ_RS01690
uniprot id: Q57769
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS00695
gene id: 243232:MJ_RS00695
uniprot id: Q57598
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Contains a large catalytic C-terminal domain that binds S-adenosyl-L-methionine and a smaller N-terminal domain that may play a role in tRNA recognition. Domains are connected by a linker region.
messages: Homotetramer composed of a dimer of dimers.

243232:MJ RS01620
gene id: 243232:MJ_RS01620
uniprot id: Q57755
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts to maintain redox homeostasis; functions as a protein disulfide reductase.
messages: Belongs to the glutaredoxin family.
messages: Cytoplasm

243232:MJ RS05385
gene id: 243232:MJ_RS05385
uniprot id: Q58408
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (PubMed:25965978). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation (By similarity).

243232:MJ RS05170
gene id: 243232:MJ_RS05170
uniprot id: Q58369
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

243232:MJ RS00100
gene id: 243232:MJ_RS00100
uniprot id: Q60331
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

243232:MJ RS03690
gene id: 243232:MJ_RS03690
uniprot id: Q58112
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

243232:MJ RS05250
gene id: 243232:MJ_RS05250
uniprot id: Q58385
names: Function
names: Similarity
messages: Belongs to the UPF0165 family.
messages: Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC2 (Potential).

243232:MJ RS04740
gene id: 243232:MJ_RS04740
uniprot id: Q58296
names: Similarity
messages: Belongs to the MoeA family.

243232:MJ RS07025
gene id: 243232:MJ_RS07025
uniprot id: Q58710
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.

243232:MJ RS03105
gene id: 243232:MJ_RS03105
uniprot id: Q58010
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the formation of acetate and ATP from acetyl-CoA by using ADP and phosphate. Can also use butyryl-CoA, but not phenylacetyl-CoA. Cannot catalyze the reverse reaction.
messages: Homodimer.
messages: In the C-terminal section; belongs to the acetate CoA ligase beta subunit family.
messages: In the N-terminal section; belongs to the acetate CoA ligase alpha subunit family.

243232:MJ RS00485
gene id: 243232:MJ_RS00485
uniprot id: Q57562
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

243232:MJ RS02950
gene id: 243232:MJ_RS02950
uniprot id: Q57979
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

243232:MJ RS02985
gene id: 243232:MJ_RS02985
uniprot id: Q57986
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system, might be able to transport Fe(2+) into or out of the cell (Probable).
messages: The G protein domain (about resides 1-184) binds GDP faster and with higher affinity than GTP and releases GTP much faster than GDP. Release of bound nucleotide causes a rearrangement of GTP-binding domain G5, which may transmit information about the nucleotide-bound state from the G-domain to the transmembrane region of FeoB and effect Fe(2+) transport.
messages: The crystallized N-terminal domain is a homodimer.

243232:MJ RS05650
gene id: 243232:MJ_RS05650
uniprot id: Q58454
names: PTM
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

243232:MJ RS03490
gene id: 243232:MJ_RS03490
uniprot id: Q58076
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS09260
gene id: 243232:MJ_RS09260
uniprot id: Q60309
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS07575
gene id: 243232:MJ_RS07575
uniprot id: Q58812
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively (By similarity).
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity (By similarity).

243232:MJ RS04785
gene id: 243232:MJ_RS04785
uniprot id: Q58305
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: To M.voltae FlaD, also to FlaE.

243232:MJ RS02680
gene id: 243232:MJ_RS02680
uniprot id: P54048
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

243232:MJ RS03370
gene id: 243232:MJ_RS03370
uniprot id: Q58054
names: Activity Regulation
names: Subunit
messages: Homodimer.
messages: Inhibited by L-phenylalanine but not by L-tyrosine or L-tryptophan.

243232:MJ RS06260
gene id: 243232:MJ_RS06260
uniprot id: Q58571
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdC/FmdC family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

243232:MJ RS01010
gene id: 243232:MJ_RS01010
uniprot id: P54023
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

243232:MJ RS01245
gene id: 243232:MJ_RS01245
uniprot id: Q57688
names: Function
names: Similarity
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: In the C-terminal section; belongs to the ThiN family.
messages: In the N-terminal section; belongs to the ThiD family.

243232:MJ RS08705
gene id: 243232:MJ_RS08705
uniprot id: Q59029
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

243232:MJ RS07430
gene id: 243232:MJ_RS07430
uniprot id: Q58785
names: Function
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

243232:MJ RS02265
gene id: 243232:MJ_RS02265
uniprot id: Q60174
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

243232:MJ RS04565
gene id: 243232:MJ_RS04565
uniprot id: Q58261
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

243232:MJ RS02440
gene id: 243232:MJ_RS02440
uniprot id: P54035
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

243232:MJ RS05745
gene id: 243232:MJ_RS05745
uniprot id: Q58473
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Monomer.

243232:MJ RS05210
gene id: 243232:MJ_RS05210
uniprot id: Q58377
names: Similarity
messages: Belongs to the peptidase C56 family.

243232:MJ RS01005
gene id: 243232:MJ_RS01005
uniprot id: P54022
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

243232:MJ RS05970
gene id: 243232:MJ_RS05970
uniprot id: Q58516
names: Similarity
messages: Belongs to the asparagine synthetase family.

243232:MJ RS08880
gene id: 243232:MJ_RS08880
uniprot id: Q59064
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated Csm2 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities.
messages: Encoded in a type III-A CRISPR locus.
messages: Part of the Csm effector complex that includes Cas10, Csm2, Csm3, Csm4 and Csm5.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

243232:MJ RS00940
gene id: 243232:MJ_RS00940
uniprot id: P54017
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

243232:MJ RS06175
gene id: 243232:MJ_RS06175
uniprot id: P81317
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS03655
gene id: 243232:MJ_RS03655
uniprot id: Q58105
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

243232:MJ RS05355
gene id: 243232:MJ_RS05355
uniprot id: Q58403
names: Function
names: Similarity
messages: Belongs to the peptidase U62 family.
messages: Probable metalloprotease.

243232:MJ RS09005
gene id: 243232:MJ_RS09005
uniprot id: Q60275
names: Similarity
messages: Belongs to the MCM family.

243232:MJ RS01675
gene id: 243232:MJ_RS01675
uniprot id: Q57766
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

243232:MJ RS05495
gene id: 243232:MJ_RS05495
uniprot id: Q58429
names: Similarity
messages: Belongs to the ABC transporter superfamily.

243232:MJ RS02890
gene id: 243232:MJ_RS02890
uniprot id: Q57967
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

243232:MJ RS08205
gene id: 243232:MJ_RS08205
uniprot id: Q58931
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: The active site is a redox-active disulfide bond.

243232:MJ RS06505
gene id: 243232:MJ_RS06505
uniprot id: Q58613
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the HepT RNase toxin family.
messages: Homodimer, probably forms a complex with antitoxin MJ1215 or MJ1217.
messages: Modified by antitoxin MJ1215 or MJ1217; probably at least 2 successive AMPylation events occur on Tyr-83.
messages: Probable toxic component of a putative type VII toxin-antitoxin (TA) system, probably an RNase. Probably neutralized by antitoxin MJ1215 or MJ1217. Neutralization may be due to AMPylation by antitoxin.

243232:MJ RS07690
gene id: 243232:MJ_RS07690
uniprot id: Q58832
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

243232:MJ RS04965
gene id: 243232:MJ_RS04965
uniprot id: Q58337
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: DNA-binding protein exhibiting the ability to bind to both single-stranded and double-stranded DNA.
messages: Homohexamer; trimer of dimers, that forms a hollow cage-like architecture.

243232:MJ RS04245
gene id: 243232:MJ_RS04245
uniprot id: Q58205
names: Similarity
names: Subcellular Location Annotation
messages: Membrane
messages: To M.jannaschii MJ1506 and MJ1561.

243232:MJ RS09115
gene id: 243232:MJ_RS09115
uniprot id: Q60264
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm
messages: Homodimer or heterodimer with another histone. Dimers then assemble into higher oligomers, with the DNA wrapped around the protein core (By similarity).

243232:MJ RS01965
gene id: 243232:MJ_RS01965
uniprot id: P54030
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

243232:MJ RS00880
gene id: 243232:MJ_RS00880
uniprot id: Q57631
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: Catalyzes the adenylation of molybdopterin as part of the biosynthesis of the molybdenum-cofactor.

243232:MJ RS01840
gene id: 243232:MJ_RS01840
uniprot id: Q57795
names: Similarity
messages: Belongs to the M.jannaschii MJ0023/MJ0349/MJ1072/MJ1074/MJ1107/MJECL16 family.

243232:MJ RS00360
gene id: 243232:MJ_RS00360
uniprot id: Q60374
names: Function
names: Similarity
messages: Belongs to the RelE toxin family.
messages: Toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin is RelB1 (Potential).

243232:MJ RS04215
gene id: 243232:MJ_RS04215
uniprot id: Q58200
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS02270
gene id: 243232:MJ_RS02270
uniprot id: Q57872
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase with a lower affinity for dUTP than for dCTP.
messages: Homotrimer (PubMed:12756253, PubMed:12909016). Two trimers assemble into a hexamer by stacking on top of each other (PubMed:12909016).
messages: Inhibited by dTTP.

243232:MJ RS03725
gene id: 243232:MJ_RS03725
uniprot id: P54058
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

243232:MJ RS07270
gene id: 243232:MJ_RS07270
uniprot id: Q58754
names: Similarity
messages: Belongs to the UPF0273 family.

243232:MJ RS05175
gene id: 243232:MJ_RS05175
uniprot id: Q58370
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

243232:MJ RS04180
gene id: 243232:MJ_RS04180
uniprot id: Q58194
names: Function
names: Similarity
messages: Belongs to the HMD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

243232:MJ RS04560
gene id: 243232:MJ_RS04560
uniprot id: Q58260
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

243232:MJ RS01340
gene id: 243232:MJ_RS01340
uniprot id: Q57703
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the phosphosulfolactate synthase family.
messages: Catalyzes the addition of sulfite to phosphoenolpyruvate (PEP) to yield (2R)-phospho-3-sulfolactate (PSL).
messages: Homotrimer.
messages: The enzyme is stereospecific.

243232:MJ RS03605
gene id: 243232:MJ_RS03605
uniprot id: Q58098
names: Similarity
messages: To M.jannaschii MJ0084 and MJ0823.

243232:MJ RS05720
gene id: 243232:MJ_RS05720
uniprot id: Q58467
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide synthase family.
messages: Cell membrane

243232:MJ RS03740
gene id: 243232:MJ_RS03740
uniprot id: Q58120
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. Trm-G10 family.
messages: Catalyzes the adenosylmethionine-dependent methylation of the exocyclic amino group (N(2)) of guanosine at position 10 of various tRNAs. Acts via a two-step process that leads to the formation of either N(2)-monomethyl (m(2)G) or N(2)-dimethylguanosine (m(2)(2)G) (By similarity).
messages: Cytoplasm
messages: Monomer.

243232:MJ RS08645
gene id: 243232:MJ_RS08645
uniprot id: Q59018
names: Cofactor
names: Similarity
messages: Belongs to the UPF0292 family.
messages: Binds two Mg(2+) per subunit.

243232:MJ RS03425
gene id: 243232:MJ_RS03425
uniprot id: Q58065
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the four-electron reduction of molecular oxygen to water.

243232:MJ RS05550
gene id: 243232:MJ_RS05550
uniprot id: Q58440
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

243232:MJ RS07265
gene id: 243232:MJ_RS07265
uniprot id: Q58753
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS08415
gene id: 243232:MJ_RS08415
uniprot id: Q58972
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS06585
gene id: 243232:MJ_RS06585
uniprot id: Q58628
names: Activity Regulation
names: Function
names: Subunit
messages: Heterooctamer of four A and four B subunits.
messages: Inhibited by magnesium, when its concentration exceeded the ATP one, and by high concentration of ATP and alpha-ketoglutarate.
messages: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

243232:MJ RS05320
gene id: 243232:MJ_RS05320
uniprot id: Q58396
names: Similarity
messages: To M.kandleri MK0008.

243232:MJ RS01030
gene id: 243232:MJ_RS01030
uniprot id: Q57650
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

243232:MJ RS05540
gene id: 243232:MJ_RS05540
uniprot id: Q58438
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To A.fulgidus AF2058.

243232:MJ RS05935
gene id: 243232:MJ_RS05935
uniprot id: Q58509
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

243232:MJ RS02975
gene id: 243232:MJ_RS02975
uniprot id: Q57984
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (By similarity). Also functions in trans to edit the amino acid moiety from incorrectly charged Ser-tRNA(Ala), and maybe also from Gly-tRNA(Ala).
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs (By similarity).
messages: Cytoplasm

243232:MJ RS05470
gene id: 243232:MJ_RS05470
uniprot id: Q58424
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

243232:MJ RS04750
gene id: 243232:MJ_RS04750
uniprot id: Q58298
names: Cofactor
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily.
messages: Binds 2 Zn(2+) ions per subunit.

243232:MJ RS08035
gene id: 243232:MJ_RS08035
uniprot id: Q58899
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
messages: Catalyzes the reversible epimerization at C-2 of UDP-N-acetylglucosamine (UDP-GlcNAc) to produce UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues.
messages: Cytoplasm
messages: Homodimer.

243232:MJ RS04400
gene id: 243232:MJ_RS04400
uniprot id: Q58233
names: Similarity
messages: To M.jannaschii MJ0084 and MJ0685.

243232:MJ RS04090
gene id: 243232:MJ_RS04090
uniprot id: Q58177
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

243232:MJ RS04860
gene id: 243232:MJ_RS04860
uniprot id: Q58319
names: Function
names: Similarity
messages: Belongs to the RelE toxin family.
messages: Toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin is RelB2 (Potential).

243232:MJ RS00655
gene id: 243232:MJ_RS00655
uniprot id: Q57591
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the HepT RNase toxin family.
messages: Homodimer, probably forms a complex with cognate antitoxin MJ0128.
messages: Modified by cognate antitoxin MJ0128; probably at least 2 successive AMPylation events occur on Tyr-83.
messages: Probable toxic component of a putative type VII toxin-antitoxin (TA) system, probably an RNase. Probably neutralized by cognate antitoxin MJ0128. Neutralization may be due to AMPylation by MJ0128.

243232:MJ RS00120
gene id: 243232:MJ_RS00120
uniprot id: Q60334
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
messages: Belongs to the archease family.

243232:MJ RS06435
gene id: 243232:MJ_RS06435
uniprot id: Q58602
names: Similarity
messages: Belongs to the UPF0058 family.

243232:MJ RS01485
gene id: 243232:MJ_RS01485
uniprot id: Q57728
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

243232:MJ RS06770
gene id: 243232:MJ_RS06770
uniprot id: Q58661
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homohexamer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

243232:MJ RS07810
gene id: 243232:MJ_RS07810
uniprot id: Q58856
names: Similarity
messages: To M.jannaschii MJ1356.

243232:MJ RS00905
gene id: 243232:MJ_RS00905
uniprot id: Q57636
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins (By similarity).
messages: Cytoplasm

243232:MJ RS03950
gene id: 243232:MJ_RS03950
uniprot id: Q58151
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide.

243232:MJ RS00305
gene id: 243232:MJ_RS00305
uniprot id: Q60367
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.

243232:MJ RS03035
gene id: 243232:MJ_RS03035
uniprot id: Q57996
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Cell membrane

243232:MJ RS06955
gene id: 243232:MJ_RS06955
uniprot id: Q58696
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

243232:MJ RS07850
gene id: 243232:MJ_RS07850
uniprot id: Q58864
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0333 family.
messages: Membrane

243232:MJ RS05715
gene id: 243232:MJ_RS05715
uniprot id: Q58466
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

243232:MJ RS07820
gene id: 243232:MJ_RS07820
uniprot id: Q58858
names: Similarity
messages: Belongs to the UPF0128 family.

243232:MJ RS06645
gene id: 243232:MJ_RS06645
uniprot id: Q58640
names: Similarity
messages: Belongs to the UPF0251 family.

243232:MJ RS00280
gene id: 243232:MJ_RS00280
uniprot id: Q60364
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: Requires divalent metal ions, preferentially magnesium, for activity (Probable). Binds 2 divalent metal cations per subunit (PubMed:12904291, PubMed:15213409). Zinc and calcium, which are present in the crystals do not support the enzymatic reaction.

243232:MJ RS08260
gene id: 243232:MJ_RS08260
uniprot id: Q58942
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MntA antitoxin family.
messages: Binds 2 Mg(2+) ions.
messages: Probable antitoxin component of a putative type VII toxin-antitoxin (TA) system. Neutralizes cognate toxic MJ1548 by di-AMPylation.
messages: Probably forms a complex with cognate toxin MJ1548.

243232:MJ RS01980
gene id: 243232:MJ_RS01980
uniprot id: Q57821
names: Caution
names: Function
names: Similarity
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity (By similarity).
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.
messages: This protein is about 60 residues too short at the N-terminus compared to its close orthologs.

243232:MJ RS01555
gene id: 243232:MJ_RS01555
uniprot id: Q57742
names: Similarity
messages: Belongs to the helicase family.

243232:MJ RS08085
gene id: 243232:MJ_RS08085
uniprot id: Q58909
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Putative gamma-glutamylcyclotransferase.

243232:MJ RS01045
gene id: 243232:MJ_RS01045
uniprot id: Q57653
names: Similarity
messages: Belongs to the HupF/HypC family.

243232:MJ RS03310
gene id: 243232:MJ_RS03310
uniprot id: Q58042
names: Similarity
messages: Belongs to the archaeal ATPase family.

243232:MJ RS08155
gene id: 243232:MJ_RS08155
uniprot id: Q58921
names: Similarity
messages: Belongs to the UPF0280 family.

243232:MJ RS08020
gene id: 243232:MJ_RS08020
uniprot id: Q58896
names: Function
names: Similarity
messages: Belongs to the F420-dependent NADP reductase family.
messages: Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and the reverse reaction, i.e. the reduction of F420 with NADPH. Probably functions in the regeneration of NADPH required in biosynthetic reactions.

243232:MJ RS03715
gene id: 243232:MJ_RS03715
uniprot id: Q58116
names: Function
names: Similarity
messages: Belongs to the HMG-CoA reductase family.
messages: Converts HMG-CoA to mevalonate.

243232:MJ RS03665
gene id: 243232:MJ_RS03665
uniprot id: Q58107
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.jannaschii MJ0803.

243232:MJ RS06615
gene id: 243232:MJ_RS06615
uniprot id: Q58634
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.jannaschii proteasome is able to cleave oligopeptides after Glu, Asp, Tyr, Phe, Trp, slightly after Arg, but not after Ala. Thus, displays caspase-like and chymotrypsin-like activities and low level of trypsin-like activity.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

243232:MJ RS06550
gene id: 243232:MJ_RS06550
uniprot id: Q58621
names: Similarity
messages: Belongs to the UPF0216 family.

243232:MJ RS00035
gene id: 243232:MJ_RS00035
uniprot id: Q60314
names: Cofactor
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.

243232:MJ RS07480
gene id: 243232:MJ_RS07480
uniprot id: Q58794
names: Similarity
messages: Belongs to the UPF0200 family.

243232:MJ RS05850
gene id: 243232:MJ_RS05850
uniprot id: Q58493
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. NifB family.
messages: Binds 3 [4Fe-4S] clusters per monomer. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. The two others probably act as substrate.
messages: Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms. NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster.
messages: Monomer.

243232:MJ RS05290
gene id: 243232:MJ_RS05290
uniprot id: P54060
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

243232:MJ RS06075
gene id: 243232:MJ_RS06075
uniprot id: Q58538
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS08145
gene id: 243232:MJ_RS08145
uniprot id: Q58919
names: Similarity
messages: Belongs to the UPF0166 family.

243232:MJ RS00410
gene id: 243232:MJ_RS00410
uniprot id: Q60387
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

243232:MJ RS00985
gene id: 243232:MJ_RS00985
uniprot id: P54019
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

243232:MJ RS02535
gene id: 243232:MJ_RS02535
uniprot id: P43409
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm
messages: Monomer.

243232:MJ RS09220
gene id: 243232:MJ_RS09220
uniprot id: Q60301
names: Function
names: Similarity
messages: In the C-terminal section; belongs to the N(4)/N(6)-methyltransferase family.
messages: Probably a G subtype restriction enzyme that recognizes an undetermined sequence and cleaves at an undetermined site. Probably also acts as an alpha subtype methylase, presumably on the same sequence.

243232:MJ RS08435
gene id: 243232:MJ_RS08435
uniprot id: Q58976
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).

243232:MJ RS04265
gene id: 243232:MJ_RS04265
uniprot id: Q58207
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family.
messages: Cell membrane

243232:MJ RS01510
gene id: 243232:MJ_RS01510
uniprot id: Q57733
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Chaperone that confers thermal protection to other proteins.
messages: Cytoplasm
messages: Homooligomer of 24 subunits. Forms a spherical shape.

243232:MJ RS07285
gene id: 243232:MJ_RS07285
uniprot id: Q58757
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS03640
gene id: 243232:MJ_RS03640
uniprot id: P54057
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

243232:MJ RS05920
gene id: 243232:MJ_RS05920
uniprot id: Q58506
names: Similarity
messages: To M.thermoautotrophicum MTH236.

243232:MJ RS04415
gene id: 243232:MJ_RS04415
uniprot id: Q58236
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS07255
gene id: 243232:MJ_RS07255
uniprot id: Q58751
names: Similarity
messages: To M.jannaschii MJ1461.

243232:MJ RS04295
gene id: 243232:MJ_RS04295
uniprot id: Q58213
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.jannaschii MJ0695.

243232:MJ RS06870
gene id: 243232:MJ_RS06870
uniprot id: Q58680
names: Similarity
messages: To B.burgdorferi BB0465 N-terminal region.

243232:MJ RS03220
gene id: 243232:MJ_RS03220
uniprot id: Q58027
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Homotetramer.

243232:MJ RS04485
gene id: 243232:MJ_RS04485
uniprot id: Q58247
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 Fe(2+) ion per subunit. Since MptB requires Fe2(+) for activity, the Fe(2+) ion likely has a catalytic role. The enzyme is also active under high concentrations of Mn(2+) in vitro.
messages: Binds 1 Zn(2+) ion per subunit. The Zn(2+) ion is proposed to have a structural role.
messages: Cyclic phosphodiesterase that hydrolyzes the cyclic phosphate of 7,8-dihydroneopterin 2',3'-cyclic phosphate (H2N-cP) and converts it to a mixture of 7,8-dihydroneopterin 2'-phosphate (H2N-2'P) and 7,8-dihydroneopterin 3'-phosphate (H2N-3'P). Is also able to utilize other phosphodiesters as substrates in vitro: hydrolysis of bis-pNPP and pNPPC produces nitrophenyl phosphate, and that of 2',3'-cAMP produces 3'-AMP. ATP, 3',5'-cAMP, GTP, 3',5'-cGMP, and 4',5'-cFMN cannot serve as substrates.
messages: Homododecamer.

243232:MJ RS06285
gene id: 243232:MJ_RS06285
uniprot id: Q58576
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is inhibited by EDTA, N-ethylmaleimide (NEM) and p-chloromercuriphenyl-sulfonic acid (PCMS) in vitro.
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates. In addition to ATP, is able to cleave other nucleotide triphosphates such as CTP, GTP and UTP, but hydrolysis of these other nucleotides is less effective in promoting proteolysis than ATP. Moreover, PAN by itself can function as a chaperone in vitro.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Alone, can form a complex composed of two stacked hexameric rings in vitro. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

243232:MJ RS05675
gene id: 243232:MJ_RS05675
uniprot id: Q58458
names: Similarity
messages: Belongs to the NodU/CmcH family.

243232:MJ RS06250
gene id: 243232:MJ_RS06250
uniprot id: Q58569
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. FwdA/FmdA family.

243232:MJ RS01235
gene id: 243232:MJ_RS01235
uniprot id: Q57686
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

243232:MJ RS07345
gene id: 243232:MJ_RS07345
uniprot id: Q58768
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS05370
gene id: 243232:MJ_RS05370
uniprot id: Q58405
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms an oligomeric complex of eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

243232:MJ RS08845
gene id: 243232:MJ_RS08845
uniprot id: Q59057
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

243232:MJ RS06345
gene id: 243232:MJ_RS06345
uniprot id: Q58589
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.jannaschii MJ0233.

243232:MJ RS00165
gene id: 243232:MJ_RS00165
uniprot id: Q60356
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

243232:MJ RS01335
gene id: 243232:MJ_RS01335
uniprot id: Q57702
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity).

243232:MJ RS00460
gene id: 243232:MJ_RS00460
uniprot id: Q57557
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

243232:MJ RS07440
gene id: 243232:MJ_RS07440
uniprot id: Q58787
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

243232:MJ RS07975
gene id: 243232:MJ_RS07975
uniprot id: Q58887
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS03455
gene id: 243232:MJ_RS03455
uniprot id: P54053
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

243232:MJ RS05635
gene id: 243232:MJ_RS05635
uniprot id: Q58451
names: Similarity
messages: Belongs to the NodU/CmcH family.

243232:MJ RS04990
gene id: 243232:MJ_RS04990
uniprot id: Q58342
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm
messages: Homodimer or heterodimer with another histone. Dimers then assemble into higher oligomers, with the DNA wrapped around the protein core (By similarity).

243232:MJ RS08255
gene id: 243232:MJ_RS08255
uniprot id: Q58941
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

243232:MJ RS03170
gene id: 243232:MJ_RS03170
uniprot id: Q58017
names: Function
names: Similarity
messages: A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-GATC-3'; the cleavage site is unknown.
messages: Belongs to the DpnII type II restriction endonuclease family.

243232:MJ RS02470
gene id: 243232:MJ_RS02470
uniprot id: P54039
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

243232:MJ RS06460
gene id: 243232:MJ_RS06460
uniprot id: Q58605
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
messages: Homodimer.

243232:MJ RS05300
gene id: 243232:MJ_RS05300
uniprot id: Q58392
names: Function
names: Similarity
messages: A beta subtype methylase that recognizes the double-stranded sequence 5'-CTAG-3', methylates C-1 on both strands, and protects the DNA from cleavage by the MjaI endonuclease.
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

243232:MJ RS00805
gene id: 243232:MJ_RS00805
uniprot id: Q57619
names: Cofactor
messages: Binds 4 [4Fe-4S] clusters.

243232:MJ RS05910
gene id: 243232:MJ_RS05910
uniprot id: Q58504
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

243232:MJ RS00785
gene id: 243232:MJ_RS00785
uniprot id: Q57615
names: Function
names: Subunit
messages: Homodimer.
messages: Participates in positive as well as negative regulation of transcription. Binds to its own promoter.

243232:MJ RS02365
gene id: 243232:MJ_RS02365
uniprot id: Q57891
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
messages: Cell membrane

243232:MJ RS03965
gene id: 243232:MJ_RS03965
uniprot id: Q58154
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrC family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

243232:MJ RS04500
gene id: 243232:MJ_RS04500
uniprot id: Q58248
names: Similarity
messages: To M.jannaschii MJ0575.

243232:MJ RS07790
gene id: 243232:MJ_RS07790
uniprot id: Q58852
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS00555
gene id: 243232:MJ_RS00555
uniprot id: Q57573
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the inositol monophosphatase superfamily. FBPase class 4 family.
messages: Homodimer.
messages: IMPase activity is inhibited by Ca(2+) and Zn(2+). In contrast to mammalian I-1-P phosphatases, is not inhibited by Li(+) up to 100 mM.
messages: Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, both D and L isomers of inositol-1-phosphate (I-1-P), 2'-AMP, pNPP, beta-glycerol phosphate, and alpha-D-glucose-1-phosphate. Cannot hydrolyze glucose-6-phosphate, fructose-6-phosphate, NAD(+) or 5'-AMP. May be involved in the biosynthesis of a unique osmolyte, di-myo-inositol 1,1-phosphate.

243232:MJ RS06080
gene id: 243232:MJ_RS06080
uniprot id: Q58539
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits. Forms a subcomplex with Rnp2 which stimulates the catalytic RNA.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

243232:MJ RS07490
gene id: 243232:MJ_RS07490
uniprot id: Q58796
names: Similarity
messages: Belongs to the DEAD box helicase family.

243232:MJ RS05140
gene id: 243232:MJ_RS05140
uniprot id: Q58363
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS07165
gene id: 243232:MJ_RS07165
uniprot id: Q58736
names: Similarity
messages: To M.jannaschii MJ0310 and MJ0714.

243232:MJ RS03835
gene id: 243232:MJ_RS03835
uniprot id: Q58128
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Cell membrane

243232:MJ RS05820
gene id: 243232:MJ_RS05820
uniprot id: Q58487
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Farnesyl- and geranyl-pyrophosphates are competitive inhibitors. Slightly inhibited by high concentration of ATP.
messages: Homodimer.

243232:MJ RS03085
gene id: 243232:MJ_RS03085
uniprot id: Q58007
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.jannaschii MJ0129 and MJ0554.

243232:MJ RS01460
gene id: 243232:MJ_RS01460
uniprot id: P81234
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.jannaschii MJ0696.

243232:MJ RS03315
gene id: 243232:MJ_RS03315
uniprot id: Q58043
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

243232:MJ RS07940
gene id: 243232:MJ_RS07940
uniprot id: Q58880
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell membrane

243232:MJ RS07615
gene id: 243232:MJ_RS07615
uniprot id: Q58817
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
messages: The intein interrupts the potential ATP-binding site.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

243232:MJ RS08400
gene id: 243232:MJ_RS08400
uniprot id: Q58969
names: Similarity
messages: Belongs to the helicase family.

243232:MJ RS02795
gene id: 243232:MJ_RS02795
uniprot id: Q57947
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS06980
gene id: 243232:MJ_RS06980
uniprot id: Q58701
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MntA antitoxin family.
messages: Binds 2 Mg(2+) ions.
messages: Putative antitoxin component of a putative type VII toxin-antitoxin (TA) system. Its cognate toxin might be MJ1304, which it might AMPylate.

243232:MJ RS03260
gene id: 243232:MJ_RS03260
uniprot id: Q58033
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

243232:MJ RS00925
gene id: 243232:MJ_RS00925
uniprot id: P54014
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

243232:MJ RS00835
gene id: 243232:MJ_RS00835
uniprot id: Q57622
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the UPF0425 family.
messages: Despite a certain similarity to SelA, PubMed:16201757 reported that this protein does not harbor SelA activity, i.e. it fails to bind to Ser-tRNA(Sec) and is not able to convert this substrate to selenocysteinyl-tRNA(Sec). It also does not convert O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).
messages: Homodimer.

243232:MJ RS03940
gene id: 243232:MJ_RS03940
uniprot id: Q58149
names: Similarity
messages: Belongs to the M.jannaschii MJ0150/MJ0739/MJ0745/MJ1460/MJ1642 family.

243232:MJ RS04285
gene id: 243232:MJ_RS04285
uniprot id: Q58211
names: Similarity
messages: Belongs to the archaeal ATPase family.

243232:MJ RS00300
gene id: 243232:MJ_RS00300
uniprot id: Q60381
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P(II) protein family.
messages: Cytoplasm
messages: Formation of the GlnK1/Amt1 complex is decreased in the presence of Mg-ATP or 2-oxoglutarate. The presence of both effectors abolishes the formation of the complex.
messages: Homotrimer (PubMed:17203075). Interacts and forms a complex with Amt1 (PubMed:17203075).
messages: Involved in the regulation of nitrogen metabolism (PubMed:17203075). Regulates the activity of its targets by protein-protein interaction in response to the nitrogen status of the cell (PubMed:17203075). Regulates the activity of the ammonia channel Amt1 via direct interaction (PubMed:17203075).

243232:MJ RS07895
gene id: 243232:MJ_RS07895
uniprot id: Q58872
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS03875
gene id: 243232:MJ_RS03875
uniprot id: Q58136
names: Similarity
messages: Belongs to the FrhG family.

243232:MJ RS08355
gene id: 243232:MJ_RS08355
uniprot id: Q58961
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS02035
gene id: 243232:MJ_RS02035
uniprot id: Q57832
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex (By similarity). Forms an Rpo3-Rpo10-Rpo11-Rpo12 complex upon coexpression (PubMed:11058130).

243232:MJ RS03470
gene id: 243232:MJ_RS03470
uniprot id: P82736
names: Similarity
messages: To M.thermoautotrophicum MTH238.

243232:MJ RS02635
gene id: 243232:MJ_RS02635
uniprot id: P81291
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Enzyme with broad specificity that catalyzes reversible hydroxyacid isomerizations via dehydration/hydration reactions. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate, a step involved in leucine biosynthesis. Catalyzes the isomerization between 2-methylmalate and 3-methylmalate, via the formation of 2-methylmaleate (citraconate), a step involved in isoleucine biosynthesis. Also displays malease activity, i.e. catalyzes the hydration of maleate to form (R)-malate.
messages: Heterotetramer of 2 LeuC and 2 LeuD. Cannot form a complex with HacB.

243232:MJ RS05835
gene id: 243232:MJ_RS05835
uniprot id: Q58490
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

243232:MJ RS04545
gene id: 243232:MJ_RS04545
uniprot id: Q58257
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

243232:MJ RS05255
gene id: 243232:MJ_RS05255
uniprot id: Q58386
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS02505
gene id: 243232:MJ_RS02505
uniprot id: P54044
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

243232:MJ RS08130
gene id: 243232:MJ_RS08130
uniprot id: Q58916
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: This is probably a Na(+)/H(+) antiporter.

243232:MJ RS06570
gene id: 243232:MJ_RS06570
uniprot id: Q58625
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

243232:MJ RS02425
gene id: 243232:MJ_RS02425
uniprot id: Q57901
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

243232:MJ RS08605
gene id: 243232:MJ_RS08605
uniprot id: Q59011
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

243232:MJ RS08745
gene id: 243232:MJ_RS08745
uniprot id: Q59037
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible SMC hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

243232:MJ RS03600
gene id: 243232:MJ_RS03600
uniprot id: Q58097
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the transamination reaction between 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) and alanine to produce pyruvate and 5-(aminomethyl)-3-furanmethanol phosphate (F1-P), the precursor for the furan moiety in methanofuran.
messages: Cytoplasm
messages: Homodimer.

243232:MJ RS07015
gene id: 243232:MJ_RS07015
uniprot id: Q58708
names: Cofactor
names: Similarity
messages: Belongs to the UPF0026 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

243232:MJ RS06270
gene id: 243232:MJ_RS06270
uniprot id: Q58573
names: Function
names: Similarity
messages: Belongs to the RelE toxin family.
messages: Toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin is RelB4 (Potential).

243232:MJ RS06945
gene id: 243232:MJ_RS06945
uniprot id: Q58694
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

243232:MJ RS05780
gene id: 243232:MJ_RS05780
uniprot id: Q58479
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS02855
gene id: 243232:MJ_RS02855
uniprot id: Q57959
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

243232:MJ RS01105
gene id: 243232:MJ_RS01105
uniprot id: Q57664
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).

243232:MJ RS04320
gene id: 243232:MJ_RS04320
uniprot id: Q58218
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

243232:MJ RS06095
gene id: 243232:MJ_RS06095
uniprot id: Q58542
names: Function
names: Similarity
messages: Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity).
messages: Belongs to the arsA ATPase family.

243232:MJ RS00400
gene id: 243232:MJ_RS00400
uniprot id: Q60386
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

243232:MJ RS00140
gene id: 243232:MJ_RS00140
uniprot id: Q60337
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

243232:MJ RS07705
gene id: 243232:MJ_RS07705
uniprot id: Q58835
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

243232:MJ RS03245
gene id: 243232:MJ_RS03245
uniprot id: Q58030
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

243232:MJ RS00635
gene id: 243232:MJ_RS00635
uniprot id: Q57587
names: Similarity
messages: To M.jannaschii MJ1213 and A.aeolicus AA15.

243232:MJ RS06795
gene id: 243232:MJ_RS06795
uniprot id: Q58666
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily.
messages: Cell membrane
messages: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane (By similarity).

243232:MJ RS03420
gene id: 243232:MJ_RS03420
uniprot id: Q58064
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).

243232:MJ RS02825
gene id: 243232:MJ_RS02825
uniprot id: Q57953
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

243232:MJ RS07485
gene id: 243232:MJ_RS07485
uniprot id: Q58795
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0333 family.
messages: Membrane

243232:MJ RS05710
gene id: 243232:MJ_RS05710
uniprot id: Q58465
names: Similarity
messages: To B.subtilis SpsE.

243232:MJ RS08840
gene id: 243232:MJ_RS08840
uniprot id: Q59056
names: Similarity
messages: Belongs to the ABC transporter superfamily.

243232:MJ RS03025
gene id: 243232:MJ_RS03025
uniprot id: Q57994
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS04700
gene id: 243232:MJ_RS04700
uniprot id: Q58289
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg-97 inactivates the nitrogenase reductase and regulates nitrogenase activity.

243232:MJ RS02465
gene id: 243232:MJ_RS02465
uniprot id: P54038
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

243232:MJ RS04705
gene id: 243232:MJ_RS04705
uniprot id: Q58290
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.jannaschii MJ0871, MJ1556 and MJ1589.

243232:MJ RS08620
gene id: 243232:MJ_RS08620
uniprot id: Q59014
names: Similarity
messages: Belongs to the biotin--protein ligase family.

243232:MJ RS08765
gene id: 243232:MJ_RS08765
uniprot id: Q59041
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm
messages: Homodimer (PubMed:10741836). Dimers then assemble into higher oligomers, with the DNA wrapped around the protein core (By similarity).

243232:MJ RS02415
gene id: 243232:MJ_RS02415
uniprot id: Q57900
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MfnE family.
messages: Catalyzes the formation of 5-(aminomethyl)-3-furanmethanol diphosphate (F1-PP) from 5-(aminomethyl)-3-furanmethanol phosphate (F1-P) and ATP (PubMed:26100040). In vitro, can also act as an adenylate kinase that catalyzes the transfer of a phosphoryl group from ATP to AMP, generating two molecules of ADP (PubMed:22002406).
messages: Homotrimer.
messages: Inhibited by EDTA.

243232:MJ RS07875
gene id: 243232:MJ_RS07875
uniprot id: Q58868
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate.

243232:MJ RS03550
gene id: 243232:MJ_RS03550
uniprot id: Q58087
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

243232:MJ RS08135
gene id: 243232:MJ_RS08135
uniprot id: Q58917
names: Function
names: Similarity
messages: Belongs to the precorrin methyltransferase family.
messages: Catalyzes the methylation of C-5 in cobalt-precorrin-7 to form cobalt-precorrin-8.

243232:MJ RS05225
gene id: 243232:MJ_RS05225
uniprot id: Q58380
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

243232:MJ RS00750
gene id: 243232:MJ_RS00750
uniprot id: Q60172
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

243232:MJ RS08015
gene id: 243232:MJ_RS08015
uniprot id: Q58895
names: Function
messages: A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-GTAC-3'; the cleavage site is unknown.

243232:MJ RS02540
gene id: 243232:MJ_RS02540
uniprot id: Q57904
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS02590
gene id: 243232:MJ_RS02590
uniprot id: Q60176
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of (S)-malate and (S)-sulfolactate to oxaloacetate and sulfopyruvate, respectively. Can use both NADH and NADPH, although activity is higher with NADPH. Oxidation of (S)-sulfolactate is observed only in the presence of NADP(+). Can also oxidize tartrate. Cannot reduce pyruvate, nor alpha-ketoglutarate.
messages: Cytoplasm
messages: Homotetramer.

243232:MJ RS08440
gene id: 243232:MJ_RS08440
uniprot id: Q58977
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
messages: Binds 2 divalent metal cations per subunit.

243232:MJ RS04715
gene id: 243232:MJ_RS04715
uniprot id: Q58292
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Probable methyltransferase that uses S-adenosylmethionine as the methyl donor. Binds neither NAD nor NADP in vitro.

243232:MJ RS00795
gene id: 243232:MJ_RS00795
uniprot id: Q57617
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

243232:MJ RS02005
gene id: 243232:MJ_RS02005
uniprot id: Q57826
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas7/Cst2/DevR family. Subtype I-a/Apern subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).

243232:MJ RS06510
gene id: 243232:MJ_RS06510
uniprot id: Q58614
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MntA antitoxin family.
messages: Binds 2 Mg(2+) ions.
messages: Probable antitoxin component of a putative type VII toxin-antitoxin (TA) system. Neutralizes cognate toxic MJ1216 by di-AMPylation.
messages: Probably forms a complex with cognate toxin MJ1216.

243232:MJ RS06455
gene id: 243232:MJ_RS06455
uniprot id: Q58604
names: Similarity
messages: Belongs to the acetyltransferase family.

243232:MJ RS06180
gene id: 243232:MJ_RS06180
uniprot id: Q58556
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

243232:MJ RS07765
gene id: 243232:MJ_RS07765
uniprot id: Q58847
names: Similarity
messages: To M.thermoautotrophicum MTH738.

243232:MJ RS07835
gene id: 243232:MJ_RS07835
uniprot id: Q58861
names: Similarity
messages: To M.jannaschii MJ0017 and MJ0139.1.

243232:MJ RS08535
gene id: 243232:MJ_RS08535
uniprot id: Q58997
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

243232:MJ RS07105
gene id: 243232:MJ_RS07105
uniprot id: Q58725
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

243232:MJ RS05575
gene id: 243232:MJ_RS05575
uniprot id: Q58443
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

243232:MJ RS05090
gene id: 243232:MJ_RS05090
uniprot id: Q58354
names: Similarity
messages: To M.jannaschii MJ0361.

243232:MJ RS02605
gene id: 243232:MJ_RS02605
uniprot id: Q57916
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

243232:MJ RS04855
gene id: 243232:MJ_RS04855
uniprot id: P0CW76
names: Function
messages: Antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is RelE2 (Potential).

243232:MJ RS08700
gene id: 243232:MJ_RS08700
uniprot id: Q59028
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

243232:MJ RS04105
gene id: 243232:MJ_RS04105
uniprot id: Q58180
names: Similarity
messages: Belongs to the 'phage' integrase family.

243232:MJ RS07530
gene id: 243232:MJ_RS07530
uniprot id: Q58803
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.

243232:MJ RS00565
gene id: 243232:MJ_RS00565
uniprot id: Q57575
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

243232:MJ RS00875
gene id: 243232:MJ_RS00875
uniprot id: Q57630
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

243232:MJ RS02395
gene id: 243232:MJ_RS02395
uniprot id: Q57896
names: Function
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

243232:MJ RS08905
gene id: 243232:MJ_RS08905
uniprot id: Q59070
names: Similarity
messages: To M.thermoautotrophicum MTH564.

243232:MJ RS00415
gene id: 243232:MJ_RS00415
uniprot id: Q60391
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

243232:MJ RS08835
gene id: 243232:MJ_RS08835
uniprot id: Q59055
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

243232:MJ RS02015
gene id: 243232:MJ_RS02015
uniprot id: Q57828
names: Domain
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated helicase Cas3 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity. Probably unwinds dsDNA templates, thus providing substrates for CRISPR-associated endonuclease Cas3-HD. Unwinding is strongly increased in the presence of ATP, implying the helicase uses ATP to unwind substrate.
messages: Proteins of this family have an N-terminal nuclease domain and a C-terminal helicase/ATPase domain. In some CRISPR/Cas systems the domains are swapped, in others they are encoded separately.

243232:MJ RS06540
gene id: 243232:MJ_RS06540
uniprot id: Q58620
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.thermoautotrophicum MTH1250.

243232:MJ RS09240
gene id: 243232:MJ_RS09240
uniprot id: Q60305
names: Similarity
messages: To M.jannaschii MJECL27.

243232:MJ RS02700
gene id: 243232:MJ_RS02700
uniprot id: Q57931
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

243232:MJ RS05050
gene id: 243232:MJ_RS05050
uniprot id: Q58347
names: Cofactor
names: Similarity
messages: Belongs to the GARS family.
messages: Binds 2 magnesium or manganese ions per subunit.

243232:MJ RS01040
gene id: 243232:MJ_RS01040
uniprot id: Q57652
names: Cofactor
messages: Binds 2 [4Fe-4S] clusters.

243232:MJ RS01020
gene id: 243232:MJ_RS01020
uniprot id: Q57649
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex (By similarity). Forms an Rpo3-Rpo10-Rpo11-Rpo12 complex upon coexpression (PubMed:11058130).

243232:MJ RS01750
gene id: 243232:MJ_RS01750
uniprot id: P81306
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS07525
gene id: 243232:MJ_RS07525
uniprot id: Q58802
names: Similarity
messages: Belongs to the UPF0107 family.

243232:MJ RS03125
gene id: 243232:MJ_RS03125
uniprot id: P54051
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

243232:MJ RS03075
gene id: 243232:MJ_RS03075
uniprot id: Q58005
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS00800
gene id: 243232:MJ_RS00800
uniprot id: P81332
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

243232:MJ RS01065
gene id: 243232:MJ_RS01065
uniprot id: Q57657
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

243232:MJ RS07710
gene id: 243232:MJ_RS07710
uniprot id: Q58836
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

243232:MJ RS08755
gene id: 243232:MJ_RS08755
uniprot id: Q59039
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.

243232:MJ RS05240
gene id: 243232:MJ_RS05240
uniprot id: Q58383
names: Similarity
messages: In the C-terminal section; belongs to the PAPS reductase family.

243232:MJ RS08230
gene id: 243232:MJ_RS08230
uniprot id: Q58936
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated (PubMed:24375099). Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions (PubMed:25917907). May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens (PubMed:24375099).
messages: Homotetramer.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine (PubMed:25917907). 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent (PubMed:24375099).

243232:MJ RS07860
gene id: 243232:MJ_RS07860
uniprot id: Q58865
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS03590
gene id: 243232:MJ_RS03590
uniprot id: Q58095
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Essential for tRNA splicing and maturation. Acts by directly joining spliced tRNA halves to mature-sized tRNAs. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends.
messages: Ligation proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RtcB reacts with GTP to form a covalent RtcB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.
messages: Monomer.

243232:MJ RS06060
gene id: 243232:MJ_RS06060
uniprot id: Q58535
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

243232:MJ RS08240
gene id: 243232:MJ_RS08240
uniprot id: Q58938
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

243232:MJ RS06765
gene id: 243232:MJ_RS06765
uniprot id: Q58660
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

243232:MJ RS02935
gene id: 243232:MJ_RS02935
uniprot id: Q57976
names: PTM
messages: Methylated at an undetermined residue between Ser-2 and Asp-26.

243232:MJ RS01310
gene id: 243232:MJ_RS01310
uniprot id: P54027
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

243232:MJ RS08670
gene id: 243232:MJ_RS08670
uniprot id: Q59023
names: Similarity
messages: Belongs to the UPF0282 family.

243232:MJ RS08315
gene id: 243232:MJ_RS08315
uniprot id: Q58953
names: Similarity
messages: Belongs to the UPF0237 family.

243232:MJ RS05075
gene id: 243232:MJ_RS05075
uniprot id: Q58352
names: Similarity
messages: Belongs to the helicase family. DinG subfamily.

243232:MJ RS04155
gene id: 243232:MJ_RS04155
uniprot id: Q58190
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS06620
gene id: 243232:MJ_RS06620
uniprot id: Q58635
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to PubMed:12130658, ProRS is unable to edit the misacylated Cys-tRNA(Pro) and Ala-tRNA(Pro), whereas according to PubMed:11408489, it hydrolyzes Ala-AMP and Ala-tRNA(Pro) by 'pretransfer' and 'posttransfer' editing activities, respectively.
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). Can inadvertently accommodate and process non-cognate amino acids such as cysteine and alanine.
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer. The dimer is functionally asymmetric: only one of the two active sites at a time is able to form prolyl-adenylate, and only one tRNA molecule binds per dimer.
messages: Inhibited by high concentrations of prolinamide.
messages: Was originally (PubMed:10642548, PubMed:10869184 and PubMed:11141055) thought to have both prolyl- and cysteinyl-tRNA synthetase activities (ProCysRS). However, recent biochemical and structural studies show that ProRS misaminoacylates tRNA(Pro) with cysteine but is unable to aminoacylate tRNA(Cys). These conflicting results may be due to the fact that much of the previous work was done with unfractionated tRNA.

243232:MJ RS03870
gene id: 243232:MJ_RS03870
uniprot id: Q58135
names: Similarity
messages: Belongs to the FrhB family.

243232:MJ RS05270
gene id: 243232:MJ_RS05270
uniprot id: Q58389
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS03280
gene id: 243232:MJ_RS03280
uniprot id: Q58037
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RimK family. MptN subfamily.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Catalyzes the ATP or GTP-dependent addition of one L-glutamate molecule to tetrahydromethanopterin, producing tetrahydrosarcinapterin.
messages: Homodimer.

243232:MJ RS04475
gene id: 243232:MJ_RS04475
uniprot id: P81324
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.thermoautotrophicum MTH421.

243232:MJ RS04535
gene id: 243232:MJ_RS04535
uniprot id: Q58255
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Cytoplasm
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

243232:MJ RS04450
gene id: 243232:MJ_RS04450
uniprot id: P81322
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0333 family.
messages: Membrane

243232:MJ RS07545
gene id: 243232:MJ_RS07545
uniprot id: Q58806
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.
messages: Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate. The substrate preference order is propionaldehyde > DL-lactaldehyde, DL-glyceraldehyde > crotonaldehyde > glycolaldehyde > acetaldehyde, acrolein > formaldehyde. No activity was observed towards methylglyoxal or glyceraldehyde-3-phosphate. Has a preference for NAD over NADP.

243232:MJ RS05725
gene id: 243232:MJ_RS05725
uniprot id: Q58469
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

243232:MJ RS06045
gene id: 243232:MJ_RS06045
uniprot id: Q58532
names: Similarity
messages: Belongs to the UPF0058 family.

243232:MJ RS03575
gene id: 243232:MJ_RS03575
uniprot id: Q58092
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the transketolase family.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Could be the product of a pseudogene. Corresponds to the C-terminal of members of this family.

243232:MJ RS01205
gene id: 243232:MJ_RS01205
uniprot id: Q57681
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

243232:MJ RS07670
gene id: 243232:MJ_RS07670
uniprot id: Q58828
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS07660
gene id: 243232:MJ_RS07660
uniprot id: Q58826
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: Consists of two subunits, CofG and CofH.

243232:MJ RS03985
gene id: 243232:MJ_RS03985
uniprot id: Q58158
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the oxidation of F420H(2) with O(2) (By similarity). May be involved in O(2) detoxification, reducing the intracellular O(2) concentration to a level allowing growth at the expense of methane formation (By similarity).
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

243232:MJ RS04660
gene id: 243232:MJ_RS04660
uniprot id: Q58280
names: Cofactor
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
messages: Binds 1 siroheme per subunit.
messages: Binds 4 [4Fe-4S] cluster.
messages: Catalyzes the reduction of sulfite to sulfide using reduced F420 as the electron source. Involved in sulfite detoxification and assimilation. Cannot use NADH or NADPH.
messages: Contains an N-terminal H(2)F420 dehydrogenase domain and a C-terminal dissimilatory-type siroheme sulfite reductase domain.
messages: Expression in Methanococcus maripaludis, a sulfite-sensitive methanogen, leads to sulfite detoxification and use of sulfite as a sole sulfur source by M. maripaludis.
messages: Induced by sulfite.

243232:MJ RS01330
gene id: 243232:MJ_RS01330
uniprot id: Q57701
names: Similarity
messages: Belongs to the peptidase A31 family.

243232:MJ RS06820
gene id: 243232:MJ_RS06820
uniprot id: Q58671
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: This is probably a Na(+)/H(+) antiporter.

243232:MJ RS08175
gene id: 243232:MJ_RS08175
uniprot id: Q58925
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family.
messages: Cytoplasm

243232:MJ RS01665
gene id: 243232:MJ_RS01665
uniprot id: Q57764
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Trimer of an alpha-beta dimer.

243232:MJ RS05215
gene id: 243232:MJ_RS05215
uniprot id: Q58378
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Inhibited by orthovanadate.
messages: Most probably acts as a phosphatase in the cytosol.

243232:MJ RS04685
gene id: 243232:MJ_RS04685
uniprot id: Q58286
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Cell membrane
messages: Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane.

243232:MJ RS04615
gene id: 243232:MJ_RS04615
uniprot id: Q58271
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

243232:MJ RS06815
gene id: 243232:MJ_RS06815
uniprot id: Q58670
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

243232:MJ RS01060
gene id: 243232:MJ_RS01060
uniprot id: Q57656
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

243232:MJ RS03130
gene id: 243232:MJ_RS03130
uniprot id: P59283
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex (By similarity). Interacts with Rpo3. Forms an Rpo3-Rpo10-Rpo11-Rpo12 complex upon coexpression (PubMed:11058130).

243232:MJ RS06120
gene id: 243232:MJ_RS06120
uniprot id: Q58546
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

243232:MJ RS08040
gene id: 243232:MJ_RS08040
uniprot id: Q58900
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily.

243232:MJ RS05735
gene id: 243232:MJ_RS05735
uniprot id: Q58471
names: Similarity
messages: To M.jannaschii MJ0977 C-terminal region.

243232:MJ RS03830
gene id: 243232:MJ_RS03830
uniprot id: Q58127
names: Similarity
messages: To Synechocystis PCC 6803 slr0903.

243232:MJ RS01290
gene id: 243232:MJ_RS01290
uniprot id: P54026
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

243232:MJ RS08550
gene id: 243232:MJ_RS08550
uniprot id: Q59000
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPI family.
messages: Catalyzes the isomerization of glucose-6-P to fructose-6-P.
messages: Competively inhibited by 6-phosphogluconate and erythrose 4-phosphate.
messages: Cytoplasm
messages: Homodimer.

243232:MJ RS01190
gene id: 243232:MJ_RS01190
uniprot id: P81304
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS06200
gene id: 243232:MJ_RS06200
uniprot id: Q58560
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

243232:MJ RS06085
gene id: 243232:MJ_RS06085
uniprot id: Q58540
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ComB family.
messages: Hydrolyzes both enantiomers of 2-phosphosulfolactate. Able to hydrolyze both enantiomers of 2-hydroxycarboxylic acids with pseudosymmetric centers of inversion. Specifically hydrolyzes (S)-phospholactate and (S)-phosphoglycerate.
messages: Inhibited by vanadate.
messages: Monomer.

243232:MJ RS06925
gene id: 243232:MJ_RS06925
uniprot id: Q58690
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Tetramer of two alpha and two beta subunits.

243232:MJ RS07630
gene id: 243232:MJ_RS07630
uniprot id: Q58820
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDH2/MDH2 oxidoreductase family.
messages: Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynthesis of both coenzyme M (with (R)-sulfolactate) and methanopterin (with alpha-ketoglutarate).
messages: Cytoplasm

243232:MJ RS03415
gene id: 243232:MJ_RS03415
uniprot id: Q58062
names: Similarity
messages: Belongs to the UPF0305 family.

243232:MJ RS09265
gene id: 243232:MJ_RS09265
uniprot id: Q60310
names: Similarity
messages: Belongs to the UPF0304 family.

243232:MJ RS01100
gene id: 243232:MJ_RS01100
uniprot id: P81232
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS01135
gene id: 243232:MJ_RS01135
uniprot id: Q57670
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit (By similarity).

243232:MJ RS05655
gene id: 243232:MJ_RS05655
uniprot id: Q58455
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

243232:MJ RS02130
gene id: 243232:MJ_RS02130
uniprot id: Q57846
names: Similarity
messages: Belongs to the MEMO1 family.

243232:MJ RS01895
gene id: 243232:MJ_RS01895
uniprot id: Q57806
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS06295
gene id: 243232:MJ_RS06295
uniprot id: Q58578
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Cell membrane

243232:MJ RS06895
gene id: 243232:MJ_RS06895
uniprot id: Q58685
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS05510
gene id: 243232:MJ_RS05510
uniprot id: Q58432
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

243232:MJ RS05610
gene id: 243232:MJ_RS05610
uniprot id: P54062
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

243232:MJ RS03700
gene id: 243232:MJ_RS03700
uniprot id: Q58114
names: Similarity
messages: Belongs to the HisA/HisF family.

243232:MJ RS01585
gene id: 243232:MJ_RS01585
uniprot id: Q57748
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

243232:MJ RS04255
gene id: 243232:MJ_RS04255
uniprot id: Q58206
names: Similarity
messages: Belongs to the ABC transporter superfamily.

243232:MJ RS01650
gene id: 243232:MJ_RS01650
uniprot id: Q57761
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cytoplasm
messages: Homodimer or homotetramer.

243232:MJ RS03185
gene id: 243232:MJ_RS03185
uniprot id: Q58020
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

243232:MJ RS00235
gene id: 243232:MJ_RS00235
uniprot id: Q60355
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family.

243232:MJ RS06845
gene id: 243232:MJ_RS06845
uniprot id: Q58676
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS06730
gene id: 243232:MJ_RS06730
uniprot id: Q58655
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm
messages: Homodimer or heterodimer with another histone. Dimers then assemble into higher oligomers, with the DNA wrapped around the protein core (By similarity).

243232:MJ RS00725
gene id: 243232:MJ_RS00725
uniprot id: Q57604
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homotetramer.
messages: Inhibited by barium and cesium.
messages: Potassium channel protein. Seems to conduct potassium at low membrane potentials.

243232:MJ RS02520
gene id: 243232:MJ_RS02520
uniprot id: P54047
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

243232:MJ RS05275
gene id: 243232:MJ_RS05275
uniprot id: P54059
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

243232:MJ RS06130
gene id: 243232:MJ_RS06130
uniprot id: Q58548
names: Caution
names: Function
names: Similarity
messages: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Induces RNA cleavage activity in the RNA polymerase. In its presence, the cleavage activity of the RNA polymerase truncates the RNA back to position +15 in a stepwise manner by releasing mainly dinucleotides from the 3'-end of the nascent RNA. The truncated RNAs are able to continue elongation. Involved in transcriptional proofreading and fidelity. Misincorporation of nucleotides during elongation of transcription leads to arrested elongation complexes which are rescued by TFS-promoted removal of a dinucleotide from the 3'-end. TFS is able to induce a cleavage resynthesis cycle in stalled elongation complexes (resulting from the next missing nucleotide or a reduced incorporation rate of a wrong nucleotide) preventing misincorporation and enabling proofreading in a post-incorporation manner. Pausing of elongation complexes is the main determinant of TFS-induced RNA cleavage.
messages: More similar by sequence similarity to the eukaryotic RNA polymerase subunits.

243232:MJ RS01700
gene id: 243232:MJ_RS01700
uniprot id: Q57770
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

243232:MJ RS08320
gene id: 243232:MJ_RS08320
uniprot id: Q58954
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency (By similarity).

243232:MJ RS07070
gene id: 243232:MJ_RS07070
uniprot id: Q58719
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

243232:MJ RS00370
gene id: 243232:MJ_RS00370
uniprot id: Q60380
names: Similarity
messages: Belongs to the archaeal ATPase family.

243232:MJ RS00965
gene id: 243232:MJ_RS00965
uniprot id: Q57645
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes only the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor.
messages: Competitively inhibited by L-ornithine.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

243232:MJ RS06365
gene id: 243232:MJ_RS06365
uniprot id: Q58592
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: The F420-non-reducing hydrogenase vhu is composed of four subunits; VhuA, VhuD, VhuG and VhuU.
messages: The large subunit of Vhu is split into VhuA and VhuU. Each contributes two ligands to the [NiFeSe] center.

243232:MJ RS02490
gene id: 243232:MJ_RS02490
uniprot id: P54042
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

243232:MJ RS09025
gene id: 243232:MJ_RS09025
uniprot id: Q60277
names: Similarity
messages: Belongs to the archaeal ATPase family.

243232:MJ RS03240
gene id: 243232:MJ_RS03240
uniprot id: Q58029
names: Similarity
messages: In the N-terminal section; belongs to the prephenate/arogenate dehydrogenase family.

243232:MJ RS04530
gene id: 243232:MJ_RS04530
uniprot id: Q58254
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known (By similarity).

243232:MJ RS00095
gene id: 243232:MJ_RS00095
uniprot id: Q60325
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

243232:MJ RS00660
gene id: 243232:MJ_RS00660
uniprot id: Q57592
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MntA antitoxin family.
messages: Binds 2 Mg(2+) ions.
messages: Probable antitoxin component of a putative type VII toxin-antitoxin (TA) system. Neutralizes cognate toxic MJ0127 by di-AMPylation.
messages: Probably forms a complex with cognate toxin MJ0127.

243232:MJ RS02060
gene id: 243232:MJ_RS02060
uniprot id: Q57837
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A site-2 regulated intramembrane protease (S2P) that cleaves type-2 transmembrane proteins within their membrane-spanning domains; its endogenous substrate is unknown. Regulated intramembrane proteolysis (RIP) occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. A membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, this enzyme), while cytoplasmic proteases finish degrading the regulatory protein, liberating the effector protein. Possible signals, S1P and substrates are unknown in this organism.
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Inhibited by 1,10-phenanthroline.
messages: Monomer.

243232:MJ RS05445
gene id: 243232:MJ_RS05445
uniprot id: Q58419
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

243232:MJ RS08350
gene id: 243232:MJ_RS08350
uniprot id: Q58960
names: Similarity
messages: Belongs to the HerA family.

243232:MJ RS05380
gene id: 243232:MJ_RS05380
uniprot id: Q58407
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RimK family. CofF subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the ATP-dependent addition of one alpha-linked L-glutamate molecule to coenzyme gamma-F420-2, producing alpha-F420-3, the major form of coenzyme F420 found in M.jannaschii. Thus, caps the gamma-polyglutamate tail of coenzyme F420 with a terminal alpha-linked glutamate. Prefers ATP to other purine nucleotide triphosphates; GTP gives about 25% of the activity observed with ATP. Cannot catalyze the addition of the following amino acids or analogs: D-glutamate, beta-glutamate, L-aspartate, L-glutamine, L-alpha-aminoadipate, or D,L-2-amino-4-phosphono-butyrate.
messages: Inhibited by KCl.
messages: Monomer.

243232:MJ RS01120
gene id: 243232:MJ_RS01120
uniprot id: Q57667
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

243232:MJ RS00970
gene id: 243232:MJ_RS00970
uniprot id: Q57646
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CGI121/TPRKB family.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, a step in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Cgi121 stimulates Bud32 kinase activity via an activation of Bud32 autophosphorylation.

243232:MJ RS01950
gene id: 243232:MJ_RS01950
uniprot id: Q57816
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer (PubMed:15558053). Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins (By similarity).

243232:MJ RS02900
gene id: 243232:MJ_RS02900
uniprot id: Q57969
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Homotetramer.
messages: Transcriptional regulator.

243232:MJ RS08910
gene id: 243232:MJ_RS08910
uniprot id: Q59071
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane

243232:MJ RS02875
gene id: 243232:MJ_RS02875
uniprot id: Q57963
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

243232:MJ RS03860
gene id: 243232:MJ_RS03860
uniprot id: Q58133
names: Function
names: Subunit
messages: Homotetramer.
messages: Participates in positive as well as negative regulation of transcription. Binds to its own promoter.

243232:MJ RS02450
gene id: 243232:MJ_RS02450
uniprot id: Q57903
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4 protein subunits. Forms a subcomplex with Rnp4 which stimulates the catalytic RNA.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

243232:MJ RS01320
gene id: 243232:MJ_RS01320
uniprot id: Q57699
names: Cofactor
messages: Binds 2 [4Fe-4S] clusters.

243232:MJ RS05795
gene id: 243232:MJ_RS05795
uniprot id: Q58482
names: Similarity
messages: To M.jannaschii MJ1503.

243232:MJ RS05410
gene id: 243232:MJ_RS05410
uniprot id: Q58413
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

243232:MJ RS03805
gene id: 243232:MJ_RS03805
uniprot id: Q58122
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

243232:MJ RS08495
gene id: 243232:MJ_RS08495
uniprot id: Q58989
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.
messages: Binds 1 Mg(2+) ion per subunit.

243232:MJ RS02930
gene id: 243232:MJ_RS02930
uniprot id: Q57975
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

243232:MJ RS02685
gene id: 243232:MJ_RS02685
uniprot id: P54049
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion (Probable).

243232:MJ RS04780
gene id: 243232:MJ_RS04780
uniprot id: Q58304
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: To M.voltae FlaC.

243232:MJ RS08290
gene id: 243232:MJ_RS08290
uniprot id: Q58948
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS08770
gene id: 243232:MJ_RS08770
uniprot id: Q59042
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

243232:MJ RS03580
gene id: 243232:MJ_RS03580
uniprot id: Q58093
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

243232:MJ RS04730
gene id: 243232:MJ_RS04730
uniprot id: Q58294
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

243232:MJ RS08895
gene id: 243232:MJ_RS08895
uniprot id: Q59068
names: Function
names: Miscellaneous
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities.
messages: Encoded in a type III-A CRISPR locus.

243232:MJ RS03980
gene id: 243232:MJ_RS03980
uniprot id: Q58157
names: Function
names: Similarity
names: Subunit
messages: Belongs to the hemerythrin family.
messages: Monomer.
messages: Oxygen-binding protein. May be involved in a storage mechanism or for delivery to oxygen-requiring enzymes. The oxygen-binding site contains two iron atoms.

243232:MJ RS08595
gene id: 243232:MJ_RS08595
uniprot id: Q59009
names: Similarity
messages: To M.jannaschii MJ1311.

243232:MJ RS04060
gene id: 243232:MJ_RS04060
uniprot id: Q58171
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
messages: Binds 2 divalent metal cations per subunit.

243232:MJ RS00315
gene id: 243232:MJ_RS00315
uniprot id: Q60369
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.

243232:MJ RS06875
gene id: 243232:MJ_RS06875
uniprot id: Q58681
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS00935
gene id: 243232:MJ_RS00935
uniprot id: P54016
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

243232:MJ RS09125
gene id: 243232:MJ_RS09125
uniprot id: Q60265
names: Function
names: Similarity
messages: Belongs to the UPF0165 family.
messages: Possibly the antitoxin component of a type II toxin-antitoxin (TA) system.

243232:MJ RS00870
gene id: 243232:MJ_RS00870
uniprot id: Q57629
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS01380
gene id: 243232:MJ_RS01380
uniprot id: Q57710
names: Function
names: Miscellaneous
names: PTM
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity).
messages: The intein interrupts the GTP-binding site.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

243232:MJ RS01280
gene id: 243232:MJ_RS01280
uniprot id: Q57694
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

243232:MJ RS06465
gene id: 243232:MJ_RS06465
uniprot id: P81326
names: Function
names: Similarity
messages: A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-CCGG-3'; the cleavage site is unknown.
messages: Belongs to the BsaWI type II restriction endonuclease family.

243232:MJ RS06735
gene id: 243232:MJ_RS06735
uniprot id: Q58656
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

243232:MJ RS04665
gene id: 243232:MJ_RS04665
uniprot id: Q58281
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.jannaschii MJ0880, MJ1556 and MJ1589.

243232:MJ RS03635
gene id: 243232:MJ_RS03635
uniprot id: Q58103
names: Similarity
messages: Belongs to the PDCD5 family.

243232:MJ RS07855
gene id: 243232:MJ_RS07855
uniprot id: P81329
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exosortase/archaeosortase family. Archaeosortase D subfamily.
messages: Cell membrane
messages: Transpeptidase that recognizes and modifies its substrate by proteolytic cleavage of a sorting signal. Following cleavage, a covalent intermediate is formed via a thioester bond between the archaeosortase and its substrate, which is then transferred and covalently attached to the cell membrane.

243232:MJ RS07950
gene id: 243232:MJ_RS07950
uniprot id: Q58882
names: Cofactor
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

243232:MJ RS08065
gene id: 243232:MJ_RS08065
uniprot id: Q58905
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

243232:MJ RS05045
gene id: 243232:MJ_RS05045
uniprot id: Q58346
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.
messages: Binds 2 divalent metal ions per subunit. Most effective are nickel and manganese.
messages: Competitively inhibited by phosphate.
messages: Monomer.
messages: Shows phosphodiesterase activity, hydrolyzing phosphodiesters bonds in the artificial chromogenic substrates bis-p-nitrophenyl phosphate (bis-pNPP), and less efficiently thymidine 5'-monophosphate p-nitrophenyl ester (pNP-TMP) and p-nitrophenylphosphorylcholine (pNPPC). No catalytic activity was found toward cAMP or cGMP, nucleotides or phospholipase substrates such as phosphatidylcholine. The physiological substrate is unknown.

243232:MJ RS08855
gene id: 243232:MJ_RS08855
uniprot id: Q59059
names: Similarity
messages: Belongs to the UPF0210 family.

243232:MJ RS03345
gene id: 243232:MJ_RS03345
uniprot id: Q58049
names: Similarity
messages: Belongs to the archaeal ATPase family.

243232:MJ RS07925
gene id: 243232:MJ_RS07925
uniprot id: Q58877
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

243232:MJ RS00490
gene id: 243232:MJ_RS00490
uniprot id: P54011
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.

243232:MJ RS06855
gene id: 243232:MJ_RS06855
uniprot id: Q58678
names: Similarity
messages: Belongs to the UPF0252 family.

243232:MJ RS08330
gene id: 243232:MJ_RS08330
uniprot id: Q58956
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.jannaschii MJ0795 and MJ1506.

243232:MJ RS05985
gene id: 243232:MJ_RS05985
uniprot id: Q58519
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.

243232:MJ RS02345
gene id: 243232:MJ_RS02345
uniprot id: Q57887
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).

243232:MJ RS05990
gene id: 243232:MJ_RS05990
uniprot id: Q58520
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

243232:MJ RS00705
gene id: 243232:MJ_RS00705
uniprot id: Q57600
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.
messages: Homohexamer. Dimer of trimers.
messages: Inhibited by ADP.

243232:MJ RS05260
gene id: 243232:MJ_RS05260
uniprot id: Q58387
names: Function
names: Similarity
messages: Belongs to the RecJ family.
messages: Single-stranded-DNA-specific exonuclease.

243232:MJ RS00455
gene id: 243232:MJ_RS00455
uniprot id: Q57556
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Cell membrane

243232:MJ RS05335
gene id: 243232:MJ_RS05335
uniprot id: Q58399
names: Similarity
messages: To M.jannaschii MJ0628.

243232:MJ RS02075
gene id: 243232:MJ_RS02075
uniprot id: Q57838
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

243232:MJ RS05890
gene id: 243232:MJ_RS05890
uniprot id: Q58500
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
messages: Forms large aggregates.

243232:MJ RS03340
gene id: 243232:MJ_RS03340
uniprot id: Q58048
names: Similarity
messages: Belongs to the peptidase A31 family.

243232:MJ RS05615
gene id: 243232:MJ_RS05615
uniprot id: P54063
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

243232:MJ RS05605
gene id: 243232:MJ_RS05605
uniprot id: Q58447
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

243232:MJ RS08740
gene id: 243232:MJ_RS08740
uniprot id: Q59036
names: Similarity
messages: Belongs to the M.jannaschii MJ0150/MJ0739/MJ0745/MJ1460/MJ1642 family.

243232:MJ RS06825
gene id: 243232:MJ_RS06825
uniprot id: Q58672
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

243232:MJ RS03515
gene id: 243232:MJ_RS03515
uniprot id: Q58081
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

243232:MJ RS03265
gene id: 243232:MJ_RS03265
uniprot id: Q58034
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Heterotetramer of two alpha and two beta subunits.

243232:MJ RS06605
gene id: 243232:MJ_RS06605
uniprot id: Q58632
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.
messages: Reversibly inhibited by O(2).

243232:MJ RS03115
gene id: 243232:MJ_RS03115
uniprot id: Q60177
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.jannaschii proteasome is able to cleave oligopeptides after Glu, Asp, Tyr, Phe, Trp, slightly after Arg, but not after Ala. Thus, displays caspase-like and chymotrypsin-like activities and low level of trypsin-like activity.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

243232:MJ RS00680
gene id: 243232:MJ_RS00680
uniprot id: Q57595
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS02510
gene id: 243232:MJ_RS02510
uniprot id: P54045
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

243232:MJ RS08795
gene id: 243232:MJ_RS08795
uniprot id: Q59047
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmI family.
messages: Cytoplasm

243232:MJ RS05390
gene id: 243232:MJ_RS05390
uniprot id: Q58409
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Component of a hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate, and even the non-physiological cis-homo(4)-aconitate with similar efficiency. These reactions are part of the biosynthesis pathway of coenzyme B. Can also catalyze the hydration of maleate to (R)-malate, and that of cis-aconitate. Cannot catalyze the hydration of citraconate and the dehydration of (S)-homocitrate, citramalate, 2-isopropylmalate, 3-isopropylmalate, citrate or threo-DL-isocitrate.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: The heterotetramer that can be formed in vitro between HacA and LeuD cannot catalyze citraconate hydration or the dehydration of 2-isopropylmalate or 3-isopropylmalate.

243232:MJ RS00405
gene id: 243232:MJ_RS00405
uniprot id: Q60390
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

243232:MJ RS03855
gene id: 243232:MJ_RS03855
uniprot id: Q58132
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons probably in the CO-dehydrogenase complex.

243232:MJ RS00435
gene id: 243232:MJ_RS00435
uniprot id: Q57552
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Cell membrane
messages: Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane.

243232:MJ RS07945
gene id: 243232:MJ_RS07945
uniprot id: Q58881
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

243232:MJ RS01345
gene id: 243232:MJ_RS01345
uniprot id: P58415
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ComD family.
messages: Heterododecamer composed of 6 subunits alpha and 6 subunits beta.
messages: Inhibited by oxygen when heated in air at 80 degrees Celsius. The enzyme is reactivated by addition of dithionite.
messages: Involved in the biosynthesis of the coenzyme M (2-mercaptoethanesulfonic acid). Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde.

243232:MJ RS07355
gene id: 243232:MJ_RS07355
uniprot id: Q58770
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide synthase family.
messages: Cell membrane

243232:MJ RS07185
gene id: 243232:MJ_RS07185
uniprot id: Q58740
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P(II) protein family.
messages: Cytoplasm
messages: Homotrimer (By similarity). Interacts and forms a complex with Amt2 (By similarity).
messages: Involved in the regulation of nitrogen metabolism (By similarity). Regulates the activity of its targets by protein-protein interaction in response to the nitrogen status of the cell (By similarity). Regulates the activity of the ammonia channel Amt2 via direct interaction (By similarity).

243232:MJ RS00230
gene id: 243232:MJ_RS00230
uniprot id: Q60354
names: Similarity
messages: Belongs to the methyltransferase superfamily.

243232:MJ RS02485
gene id: 243232:MJ_RS02485
uniprot id: P54041
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

243232:MJ RS07410
gene id: 243232:MJ_RS07410
uniprot id: Q58780
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

243232:MJ RS00170
gene id: 243232:MJ_RS00170
uniprot id: Q60349
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

243232:MJ RS07620
gene id: 243232:MJ_RS07620
uniprot id: Q58818
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Homodimer or monomer. The Ni-sirohydrochlorin a,c-diamide reductive cyclase complex is composed of a NifH homolog component CfbC and a NifD homolog component CfbD.
messages: Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes both the six-electron reduction of the tetrahydroporphyrin ring system and the gamma-lactamization of the c-acetamide side chain of Ni-sirohydrochlorin a,c-diamide to yield 15,17(3)-seco-F430-17(3)-acid (seco-F430), the last intermediate in the biosynthesis of the coenzyme F430.

243232:MJ RS02600
gene id: 243232:MJ_RS02600
uniprot id: Q57915
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS02865
gene id: 243232:MJ_RS02865
uniprot id: Q57961
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm
messages: Homohexamer.

243232:MJ RS04150
gene id: 243232:MJ_RS04150
uniprot id: Q58189
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS08420
gene id: 243232:MJ_RS08420
uniprot id: Q58973
names: Function
names: Similarity
messages: Belongs to the precorrin methyltransferase family.
messages: Catalyzes the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5A.

243232:MJ RS06420
gene id: 243232:MJ_RS06420
uniprot id: P54065
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

243232:MJ RS01355
gene id: 243232:MJ_RS01355
uniprot id: Q57705
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

243232:MJ RS03435
gene id: 243232:MJ_RS03435
uniprot id: Q58067
names: Similarity
messages: Belongs to the peptidase S49 family.

243232:MJ RS08445
gene id: 243232:MJ_RS08445
uniprot id: Q58978
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

243232:MJ RS02480
gene id: 243232:MJ_RS02480
uniprot id: P54110
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

243232:MJ RS06240
gene id: 243232:MJ_RS06240
uniprot id: Q58567
names: Cofactor
messages: Binds 2 [4Fe-4S] clusters.

243232:MJ RS02350
gene id: 243232:MJ_RS02350
uniprot id: Q57888
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: Consists of two subunits, CofG and CofH.

243232:MJ RS06700
gene id: 243232:MJ_RS06700
uniprot id: Q58649
names: Similarity
messages: Belongs to the UPF0254 family.

243232:MJ RS01630
gene id: 243232:MJ_RS01630
uniprot id: Q57757
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the arginase family. Agmatinase subfamily.
messages: Binds 2 Fe(2+) ions per subunit. Can also use Mn(2+), with lower efficiency.
messages: Catalyzes the formation of putrescine from agmatine.
messages: Forms multimers.
messages: Inhibited by putrescine and by the substrate analog arginine. Inactive when the purified enzyme is incubated with dithiothreitol followed by excess iodoacetic acid or N-ethylmaleimide.

243232:MJ RS03010
gene id: 243232:MJ_RS03010
uniprot id: Q57991
names: Similarity
messages: Belongs to the aspartokinase family.

243232:MJ RS07305
gene id: 243232:MJ_RS07305
uniprot id: Q58760
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS08710
gene id: 243232:MJ_RS08710
uniprot id: Q59030
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

243232:MJ RS01185
gene id: 243232:MJ_RS01185
uniprot id: Q57679
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit (By similarity). Magnesium ions are required for optimal activity, with Mn(2+), Zn(2+) and Ni(2+) supporting <50% of the maximum rate (PubMed:11452035).
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP (PubMed:10404228, PubMed:11452035). Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions (PubMed:11452035). Shows very low activity on GTP or dGTP, both of which are hydrolyzed more than 100-fold less efficiently than XTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP, and toward 6-N-hydroxylaminopurine deoxynucleoside triphosphate (dHAPTP) (PubMed:10404228, PubMed:11452035). Displays neither endonuclease nor 3'-exonuclease activities (PubMed:11452035).

243232:MJ RS01015
gene id: 243232:MJ_RS01015
uniprot id: P54024
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

243232:MJ RS06035
gene id: 243232:MJ_RS06035
uniprot id: Q58530
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity provided by the Kae1 region seems to be regulated via phosphorylation by the protein kinase Bud32, which is itself activated by Cgi121.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction (By similarity). The Bud32 domain probably displays kinase activity that regulates Kae1 function. In vitro, exhibits low ATPase activity, but does not bind DNA and does not have endonuclease activity.

243232:MJ RS08685
gene id: 243232:MJ_RS08685
uniprot id: Q59025
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

243232:MJ RS05690
gene id: 243232:MJ_RS05690
uniprot id: Q58461
names: Similarity
messages: Belongs to the polysaccharide synthase family.

243232:MJ RS03960
gene id: 243232:MJ_RS03960
uniprot id: Q58153
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrB family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

243232:MJ RS02575
gene id: 243232:MJ_RS02575
uniprot id: Q57911
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

243232:MJ RS00345
gene id: 243232:MJ_RS00345
uniprot id: Q60372
names: Similarity
messages: Belongs to the UPF0212 family.

243232:MJ RS01560
gene id: 243232:MJ_RS01560
uniprot id: Q57743
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity.

243232:MJ RS04625
gene id: 243232:MJ_RS04625
uniprot id: Q58273
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrB family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

243232:MJ RS05200
gene id: 243232:MJ_RS05200
uniprot id: Q58375
names: Function
names: Similarity
names: Subunit
messages: Belongs to the precorrin methyltransferase family.
messages: Catalyzes the two successive C-2 and C-7 methylation reactions involved in the conversion of uroporphyrinogen III to precorrin-2 via the intermediate formation of precorrin-1. It is a step in the biosynthesis of both cobalamin (vitamin B12) and coenzyme F430.
messages: Homodimer.

243232:MJ RS05950
gene id: 243232:MJ_RS05950
uniprot id: Q58513
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Cell membrane

243232:MJ RS04000
gene id: 243232:MJ_RS04000
uniprot id: Q58161
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

243232:MJ RS05770
gene id: 243232:MJ_RS05770
uniprot id: Q58478
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Cell membrane

243232:MJ RS09090
gene id: 243232:MJ_RS09090
uniprot id: Q60283
names: Similarity
messages: Belongs to the ParA family.

243232:MJ RS02330
gene id: 243232:MJ_RS02330
uniprot id: Q57884
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.
messages: Homodimer.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion.

243232:MJ RS04410
gene id: 243232:MJ_RS04410
uniprot id: Q58235
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FKBP-type PPIase family.
messages: Catalyzes the cis-trans isomerization of peptidyl prolyl bonds and accelerates protein folding (By similarity). Also exhibits chaperone-like activity (PubMed:21262232).
messages: Contains an N-terminal PPIase domain, an IF (Insert in the Flap) domain and a C-terminal domain (CTD). The CTD mediates dimerization. Chaperone activity requires both the IF domain and the CTD.
messages: Homodimer.

243232:MJ RS02925
gene id: 243232:MJ_RS02925
uniprot id: Q57974
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.jannaschii MJ0129 and MJ0587.

243232:MJ RS01415
gene id: 243232:MJ_RS01415
uniprot id: Q57717
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

243232:MJ RS08185
gene id: 243232:MJ_RS08185
uniprot id: Q58927
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

243232:MJ RS06300
gene id: 243232:MJ_RS06300
uniprot id: Q58579
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Alkylation of both Cys-126 and Cys-143 results in complete loss of enzymatic activity.
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. To a lesser extent, is also able to utilize other nucleotides such as CTP and GTP as substrates, producing the modified coenzymes, flavin cytosine dinucleotide (FCD) and flavin guanine dinucleotide (FGD), respectively. Does not catalyze the reverse reaction to produce FMN and ATP from FAD and PPi. Does not function as a glycerol-3-phosphate cytidylyltransferase, as previously annotated in the complete genome.
messages: Divalent metal cations. The best activity is observed with Co(2+), where the activity is 4 and 2.5 times greater than that with Mg(2+) and Mn(2+), respectively.
messages: Homodimer.
messages: Is inhibited by the product PPi.

243232:MJ RS03030
gene id: 243232:MJ_RS03030
uniprot id: Q57995
names: Similarity
messages: To M.jannaschii MJ0838.

243232:MJ RS07360
gene id: 243232:MJ_RS07360
uniprot id: Q58771
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

243232:MJ RS08975
gene id: 243232:MJ_RS08975
uniprot id: Q60270
names: Similarity
messages: Belongs to the HerA family.

243232:MJ RS00735
gene id: 243232:MJ_RS00735
uniprot id: Q57605
names: Function
names: Similarity
names: Subunit
messages: Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
messages: Homodimer.
messages: Involved in the archaeal biosynthesis of heme. Catalyzes the oxiation of precorrin-2 into sirohydroclorin (By similarity).

243232:MJ RS03460
gene id: 243232:MJ_RS03460
uniprot id: Q58071
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

243232:MJ RS03020
gene id: 243232:MJ_RS03020
uniprot id: Q57993
names: Similarity
messages: Belongs to the OsmC/Ohr family.

243232:MJ RS00260
gene id: 243232:MJ_RS00260
uniprot id: Q60363
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

243232:MJ RS06600
gene id: 243232:MJ_RS06600
uniprot id: Q58631
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This protein processes pre-crRNA into individual crRNA units.

243232:MJ RS02475
gene id: 243232:MJ_RS02475
uniprot id: P54040
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

243232:MJ RS04235
gene id: 243232:MJ_RS04235
uniprot id: Q58203
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.jannaschii MJ0706 and Synechocystis PCC 6803 slr1478.

243232:MJ RS05185
gene id: 243232:MJ_RS05185
uniprot id: Q58372
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4 protein subunits. Forms a subcomplex with Rnp1 which stimulates the catalytic RNA.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

243232:MJ RS07540
gene id: 243232:MJ_RS07540
uniprot id: Q58805
names: Similarity
messages: Belongs to the UPF0113 family.

243232:MJ RS02495
gene id: 243232:MJ_RS02495
uniprot id: P54010
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

243232:MJ RS05825
gene id: 243232:MJ_RS05825
uniprot id: Q58488
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).

243232:MJ RS07590
gene id: 243232:MJ_RS07590
uniprot id: Q58813
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldolase class II family. AraD/FucA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde (PubMed:16585745). Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S-lactaldehyde (Ref.2, PubMed:16585745, PubMed:17927915, PubMed:22418259). FucA possesses a high specificity for the dihydroxyacetone phosphate (DHAP), but accepts a great variety of different aldehydes such as DL-glyceraldehyde and glycolaldehyde (PubMed:16585745, PubMed:17927915).
messages: Trimethyl phosphonoacetate and DL-threose are competitive inhibitors with respect to dihydroxyacetone phosphate, and uncompetitive inhibitors with respect to DL-glyceraldehyde.

243232:MJ RS09165
gene id: 243232:MJ_RS09165
uniprot id: Q60293
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS04580
gene id: 243232:MJ_RS04580
uniprot id: Q58264
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

243232:MJ RS07640
gene id: 243232:MJ_RS07640
uniprot id: Q58822
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-hydroxybenzoate (HB) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylphenol 5'-phosphate (beta-RFH-P) (PubMed:21634403). Also catalyzes the condensation of 4-aminobenzoate (pABA) with PRPP to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) (PubMed:15262968, PubMed:21634403). Only 4-hydroxybenzoate is known to be biosynthesized by methanogenic archaea, but 4-aminobenzoate can be used as substrate by growing methanogens when it is present in the growth medium (PubMed:21634403).
messages: Homodimer.
messages: Lacks any chromogenic cofactor, and the presence of pyridoxal phosphate and the mechanistically related pyruvoyl cofactors has been strictly excluded.

243232:MJ RS07130
gene id: 243232:MJ_RS07130
uniprot id: P81327
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS07315
gene id: 243232:MJ_RS07315
uniprot id: Q58762
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
messages: Cell membrane
messages: Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (WtpC), two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).

243232:MJ RS08660
gene id: 243232:MJ_RS08660
uniprot id: Q59021
names: Similarity
messages: Belongs to the UPF0179 family.

243232:MJ RS06575
gene id: 243232:MJ_RS06575
uniprot id: Q58626
names: Activity Regulation
names: Function
names: Subunit
messages: Heterooctamer of four A and four B subunits.
messages: Inhibited by magnesium, when its concentration exceeded the ATP one, and by high concentration of ATP and alpha-ketoglutarate.
messages: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

243232:MJ RS08580
gene id: 243232:MJ_RS08580
uniprot id: Q59006
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

243232:MJ RS03065
gene id: 243232:MJ_RS03065
uniprot id: Q58002
names: Similarity
messages: To M.jannaschii MJ0766.

243232:MJ RS08875
gene id: 243232:MJ_RS08875
uniprot id: Q59063
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated Csm3 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities.
messages: Encoded in a type III-A CRISPR locus.
messages: Part of the Csm effector complex that includes Cas10, Csm2, Csm3, Csm4 and Csm5 (By similarity). Stable Csm3-Csm4 (which crystallizes as 2 heterodimers) and Cas10-Csm1-Csm3-Csm4 subcomplexes can be isolated; Cas10 and Csm3 probably do not directly interact (PubMed:25451598).
messages: This subunit has the target ssRNA endonuclease activity; it cleaves multiple sites in the target RNA at 6 nucleotide intervals (By similarity). The Csm3-Csm4 complex binds both crRNA and a non-specific RNA; Csm3 alone was not seen to bind RNA (PubMed:25451598).

243232:MJ RS00810
gene id: 243232:MJ_RS00810
uniprot id: Q57620
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8) (Potential).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

243232:MJ RS00855
gene id: 243232:MJ_RS00855
uniprot id: Q57626
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family.

243232:MJ RS02325
gene id: 243232:MJ_RS02325
uniprot id: Q57883
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane

243232:MJ RS06230
gene id: 243232:MJ_RS06230
uniprot id: Q58565
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster.

243232:MJ RS07830
gene id: 243232:MJ_RS07830
uniprot id: Q58860
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

243232:MJ RS04375
gene id: 243232:MJ_RS04375
uniprot id: Q58227
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

243232:MJ RS07220
gene id: 243232:MJ_RS07220
uniprot id: Q58746
names: Similarity
messages: Belongs to the glutamate synthase family.

243232:MJ RS02160
gene id: 243232:MJ_RS02160
uniprot id: Q57851
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

243232:MJ RS05180
gene id: 243232:MJ_RS05180
uniprot id: Q58371
names: Similarity
messages: Belongs to the MCM family.

243232:MJ RS05805
gene id: 243232:MJ_RS05805
uniprot id: Q58484
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

243232:MJ RS06890
gene id: 243232:MJ_RS06890
uniprot id: P81320
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS09120
gene id: 243232:MJ_RS09120
uniprot id: Q60288
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a type II toxin-antitoxin (TA) system. An RNase.

243232:MJ RS07735
gene id: 243232:MJ_RS07735
uniprot id: Q58841
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

243232:MJ RS03800
gene id: 243232:MJ_RS03800
uniprot id: Q58121
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS06720
gene id: 243232:MJ_RS06720
uniprot id: Q58653
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Inhibited by EDTA in vitro.

243232:MJ RS05220
gene id: 243232:MJ_RS05220
uniprot id: Q58379
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

243232:MJ RS00110
gene id: 243232:MJ_RS00110
uniprot id: Q60342
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

243232:MJ RS07550
gene id: 243232:MJ_RS07550
uniprot id: Q58807
names: Similarity
messages: Belongs to the UPF0288 family.

243232:MJ RS07740
gene id: 243232:MJ_RS07740
uniprot id: Q58842
names: Caution
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: Ile-16 is present instead of the conserved His which is expected to be an active site residue. Substrate-binding sites are also not conserved. Thus, this enzyme may not display fae activity.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

243232:MJ RS00285
gene id: 243232:MJ_RS00285
uniprot id: Q60365
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 magnesium ion per subunit. This ion is coordinated by a threonine and an asparagine, and by the alpha- and beta-phosphates of CDP.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN). Can also utilize UTP as the phosphate donor, although less efficiently, and it is unclear if ATP and GTP can also serve as substrates (PubMed:18245297) or not (PubMed:18073108).
messages: Monomer.

243232:MJ RS06325
gene id: 243232:MJ_RS06325
uniprot id: Q58585
names: Similarity
messages: Belongs to the AOR/FOR family.

243232:MJ RS02690
gene id: 243232:MJ_RS02690
uniprot id: P54050
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

243232:MJ RS02305
gene id: 243232:MJ_RS02305
uniprot id: Q57879
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS00340
gene id: 243232:MJ_RS00340
uniprot id: Q60371
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Cell membrane

243232:MJ RS01155
gene id: 243232:MJ_RS01155
uniprot id: Q57674
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Cell membrane

243232:MJ RS00135
gene id: 243232:MJ_RS00135
uniprot id: Q60336
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exosortase/archaeosortase family. Archaeosortase E subfamily.
messages: Cell membrane
messages: Transpeptidase that recognizes and modifies its substrate by proteolytic cleavage of a sorting signal. Following cleavage, a covalent intermediate is formed via a thioester bond between the archaeosortase and its substrate, which is then transferred and covalently attached to the cell membrane.

243232:MJ RS08215
gene id: 243232:MJ_RS08215
uniprot id: Q58933
names: Function
names: Similarity
messages: Belongs to the L-seryl-tRNA(Sec) kinase family.
messages: Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis.

243232:MJ RS02940
gene id: 243232:MJ_RS02940
uniprot id: Q57977
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of pseudouridine at position 914 (Psi914) in 16S rRNA. Is not able to methylate uridine at this position.

243232:MJ RS04825
gene id: 243232:MJ_RS04825
uniprot id: Q58313
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS07845
gene id: 243232:MJ_RS07845
uniprot id: Q58863
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS01285
gene id: 243232:MJ_RS01285
uniprot id: Q57695
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

243232:MJ RS04970
gene id: 243232:MJ_RS04970
uniprot id: Q58338
names: Function
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.
messages: Putative protein methyltransferase using S-adenosyl-L-methionine as the methyl donor. May methylate a Gln residue in target proteins (By similarity).

243232:MJ RS03565
gene id: 243232:MJ_RS03565
uniprot id: Q58090
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

243232:MJ RS01595
gene id: 243232:MJ_RS01595
uniprot id: Q57750
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

243232:MJ RS04190
gene id: 243232:MJ_RS04190
uniprot id: P81231
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.jannaschii MJ0795.1 and MJ1249.1.

243232:MJ RS03210
gene id: 243232:MJ_RS03210
uniprot id: Q58025
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPase class C family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm

243232:MJ RS04225
gene id: 243232:MJ_RS04225
uniprot id: Q58202
names: Subcellular Location Annotation
messages: Cell membrane

243232:MJ RS00860
gene id: 243232:MJ_RS00860
uniprot id: Q57627
names: Subcellular Location Annotation
messages: Membrane

243232:MJ RS04355
gene id: 243232:MJ_RS04355
uniprot id: Q58223
names: Function
names: Similarity
messages: Belongs to the precorrin methyltransferase family.
messages: Methyltransferase that likely catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV. May also convert cobalt-precorrin-3 to cobalt-precorrin-4 (By similarity).