224324:AQ RS02790
gene id: 224324:AQ_RS02790
uniprot id: O66919
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

224324:AQ RS00845
gene id: 224324:AQ_RS00845
uniprot id: O66584
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

224324:AQ RS03580
gene id: 224324:AQ_RS03580
uniprot id: O67057
names: Similarity
messages: Belongs to the band 7/mec-2 family.

224324:AQ RS00255
gene id: 224324:AQ_RS00255
uniprot id: O66475
names: Function
names: Subunit
messages: Homotetramer.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

224324:AQ RS07375
gene id: 224324:AQ_RS07375
uniprot id: O67722
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

224324:AQ RS02210
gene id: 224324:AQ_RS02210
uniprot id: O66820
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

224324:AQ RS03940
gene id: 224324:AQ_RS03940
uniprot id: O67120
names: Similarity
messages: Belongs to the MotB family.

224324:AQ RS02370
gene id: 224324:AQ_RS02370
uniprot id: O66849
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Feedback inhibited by tryptophan.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).

224324:AQ RS07385
gene id: 224324:AQ_RS07385
uniprot id: O67724
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

224324:AQ RS02915
gene id: 224324:AQ_RS02915
uniprot id: O66944
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity).
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11 (By similarity).

224324:AQ RS08610
gene id: 224324:AQ_RS08610
uniprot id: O67938
names: Similarity
messages: Belongs to the SCO1/2 family.

224324:AQ RS05235
gene id: 224324:AQ_RS05235
uniprot id: O67353
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

224324:AQ RS06150
gene id: 224324:AQ_RS06150
uniprot id: O67520
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

224324:AQ RS03700
gene id: 224324:AQ_RS03700
uniprot id: O67077
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: The isolated protease domain (residues 405-634) forms a stable hexamer.

224324:AQ RS04720
gene id: 224324:AQ_RS04720
uniprot id: O67262
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

224324:AQ RS05215
gene id: 224324:AQ_RS05215
uniprot id: O67350
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

224324:AQ RS06290
gene id: 224324:AQ_RS06290
uniprot id: O67545
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS00515
gene id: 224324:AQ_RS00515
uniprot id: O66523
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

224324:AQ RS02735
gene id: 224324:AQ_RS02735
uniprot id: O66908
names: Function
names: Similarity
messages: Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity).
messages: Belongs to the arsA ATPase family.

224324:AQ RS02350
gene id: 224324:AQ_RS02350
uniprot id: O66845
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS05475
gene id: 224324:AQ_RS05475
uniprot id: O67396
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

224324:AQ RS07420
gene id: 224324:AQ_RS07420
uniprot id: O67730
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

224324:AQ RS02840
gene id: 224324:AQ_RS02840
uniprot id: O66929
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.

224324:AQ RS06110
gene id: 224324:AQ_RS06110
uniprot id: O67512
names: Similarity
messages: Belongs to the glutamate synthase family.

224324:AQ RS07995
gene id: 224324:AQ_RS07995
uniprot id: O67829
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

224324:AQ RS06870
gene id: 224324:AQ_RS06870
uniprot id: O67639
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the encapsulin family. Family 1 subfamily.
messages: Encapsulin nanocompartment

224324:AQ RS02685
gene id: 224324:AQ_RS02685
uniprot id: O66898
names: Similarity
messages: Belongs to the peptidase A31 family.

224324:AQ RS03670
gene id: 224324:AQ_RS03670
uniprot id: O67073
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

224324:AQ RS04725
gene id: 224324:AQ_RS04725
uniprot id: O67263
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

224324:AQ RS01200
gene id: 224324:AQ_RS01200
uniprot id: O66648
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS02945
gene id: 224324:AQ_RS02945
uniprot id: O66949
names: Cofactor
names: Similarity
messages: Belongs to the GARS family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

224324:AQ RS04705
gene id: 224324:AQ_RS04705
uniprot id: O67259
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

224324:AQ RS07800
gene id: 224324:AQ_RS07800
uniprot id: O67792
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

224324:AQ RS03280
gene id: 224324:AQ_RS03280
uniprot id: O67008
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS07475
gene id: 224324:AQ_RS07475
uniprot id: O67741
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

224324:AQ RS06505
gene id: 224324:AQ_RS06505
uniprot id: O67582
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

224324:AQ RS00575
gene id: 224324:AQ_RS00575
uniprot id: O66534
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

224324:AQ RS07120
gene id: 224324:AQ_RS07120
uniprot id: O67681
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

224324:AQ RS01190
gene id: 224324:AQ_RS01190
uniprot id: O66646
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
messages: The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).

224324:AQ RS00850
gene id: 224324:AQ_RS00850
uniprot id: O66585
names: Similarity
messages: Belongs to the anthranilate phosphoribosyltransferase family.

224324:AQ RS02895
gene id: 224324:AQ_RS02895
uniprot id: O66940
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

224324:AQ RS00610
gene id: 224324:AQ_RS00610
uniprot id: O66540
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

224324:AQ RS06635
gene id: 224324:AQ_RS06635
uniprot id: O67601
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 83 family.
messages: Cell membrane

224324:AQ RS00525
gene id: 224324:AQ_RS00525
uniprot id: O66525
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS07155
gene id: 224324:AQ_RS07155
uniprot id: O67687
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

224324:AQ RS00510
gene id: 224324:AQ_RS00510
uniprot id: O66522
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS02510
gene id: 224324:AQ_RS02510
uniprot id: O66873
names: Subcellular Location Annotation
messages: Mitochondrion

224324:AQ RS05060
gene id: 224324:AQ_RS05060
uniprot id: O67320
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family. GSP D subfamily.
messages: Cell outer membrane

224324:AQ RS05040
gene id: 224324:AQ_RS05040
uniprot id: O67316
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

224324:AQ RS04080
gene id: 224324:AQ_RS04080
uniprot id: O67148
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

224324:AQ RS03260
gene id: 224324:AQ_RS03260
uniprot id: O67004
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

224324:AQ RS00945
gene id: 224324:AQ_RS00945
uniprot id: O66603
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Toroid-shaped homodecamer, composed of two pentamers of five dimers.

224324:AQ RS00085
gene id: 224324:AQ_RS00085
uniprot id: O66443
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

224324:AQ RS03140
gene id: 224324:AQ_RS03140
uniprot id: O66986
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

224324:AQ RS02620
gene id: 224324:AQ_RS02620
uniprot id: O66888
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

224324:AQ RS02465
gene id: 224324:AQ_RS02465
uniprot id: O66865
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

224324:AQ RS06665
gene id: 224324:AQ_RS06665
uniprot id: O67607
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

224324:AQ RS00980
gene id: 224324:AQ_RS00980
uniprot id: O66610
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

224324:AQ RS03405
gene id: 224324:AQ_RS03405
uniprot id: O67029
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

224324:AQ RS07470
gene id: 224324:AQ_RS07470
uniprot id: O67740
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

224324:AQ RS02750
gene id: 224324:AQ_RS02750
uniprot id: O66911
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

224324:AQ RS01315
gene id: 224324:AQ_RS01315
uniprot id: O66667
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS04500
gene id: 224324:AQ_RS04500
uniprot id: O67222
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

224324:AQ RS01710
gene id: 224324:AQ_RS01710
uniprot id: O66734
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

224324:AQ RS02385
gene id: 224324:AQ_RS02385
uniprot id: O66851
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.

224324:AQ RS08170
gene id: 224324:AQ_RS08170
uniprot id: O67860
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS02170
gene id: 224324:AQ_RS02170
uniprot id: O66813
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

224324:AQ RS07975
gene id: 224324:AQ_RS07975
uniprot id: O67825
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).

224324:AQ RS04155
gene id: 224324:AQ_RS04155
uniprot id: O67161
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
messages: Cytoplasm
messages: Homotetramer.

224324:AQ RS08490
gene id: 224324:AQ_RS08490
uniprot id: O67916
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

224324:AQ RS08340
gene id: 224324:AQ_RS08340
uniprot id: O67889
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS03310
gene id: 224324:AQ_RS03310
uniprot id: O67014
names: Similarity
messages: Belongs to the MreC family.

224324:AQ RS02810
gene id: 224324:AQ_RS02810
uniprot id: O66923
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

224324:AQ RS08730
gene id: 224324:AQ_RS08730
uniprot id: O66405
names: Similarity
messages: To A.aeolicus AA07 and AA34.

224324:AQ RS08210
gene id: 224324:AQ_RS08210
uniprot id: O67866
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

224324:AQ RS03980
gene id: 224324:AQ_RS03980
uniprot id: O67128
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

224324:AQ RS07355
gene id: 224324:AQ_RS07355
uniprot id: O67719
names: Similarity
messages: Belongs to the peptidase U62 family.

224324:AQ RS02075
gene id: 224324:AQ_RS02075
uniprot id: O66799
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

224324:AQ RS03000
gene id: 224324:AQ_RS03000
uniprot id: O66960
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS03500
gene id: 224324:AQ_RS03500
uniprot id: O67044
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

224324:AQ RS03190
gene id: 224324:AQ_RS03190
uniprot id: O66995
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

224324:AQ RS05170
gene id: 224324:AQ_RS05170
uniprot id: O67341
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

224324:AQ RS01140
gene id: 224324:AQ_RS01140
uniprot id: O66636
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

224324:AQ RS05410
gene id: 224324:AQ_RS05410
uniprot id: O67383
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

224324:AQ RS07700
gene id: 224324:AQ_RS07700
uniprot id: O67775
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

224324:AQ RS06235
gene id: 224324:AQ_RS06235
uniprot id: O67536
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

224324:AQ RS05035
gene id: 224324:AQ_RS05035
uniprot id: O67315
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

224324:AQ RS01510
gene id: 224324:AQ_RS01510
uniprot id: O66697
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

224324:AQ RS02195
gene id: 224324:AQ_RS02195
uniprot id: O66818
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS03765
gene id: 224324:AQ_RS03765
uniprot id: O67087
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

224324:AQ RS03640
gene id: 224324:AQ_RS03640
uniprot id: O67068
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

224324:AQ RS03570
gene id: 224324:AQ_RS03570
uniprot id: O67055
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

224324:AQ RS07200
gene id: 224324:AQ_RS07200
uniprot id: O67694
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane
messages: Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
messages: The accessory proteins ExbB and ExbD seem to form a complex with TonB.

224324:AQ RS01980
gene id: 224324:AQ_RS01980
uniprot id: O66780
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

224324:AQ RS03950
gene id: 224324:AQ_RS03950
uniprot id: O67122
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MotA family.
messages: Cell membrane
messages: Each stator complex is composed of 4 MotA and 2 MotB subunits. 2 A subunits and 1 B subunit are thought to form a single ion channel, so that each stator complex contains two channels (By similarity).
messages: MotA and MotB comprise the stator element of the flagellar motor complex. Required for rotation of the flagellar motor. Probable transmembrane proton channel (By similarity).

224324:AQ RS01890
gene id: 224324:AQ_RS01890
uniprot id: O66767
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS06025
gene id: 224324:AQ_RS06025
uniprot id: O67495
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell inner membrane
messages: FliM is one of 2 proteins (FliG, FliN) that might form a switch complex that is proposed to be located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (Potential).

224324:AQ RS04650
gene id: 224324:AQ_RS04650
uniprot id: O67250
names: Similarity
messages: Belongs to the DprA/Smf family.

224324:AQ RS04580
gene id: 224324:AQ_RS04580
uniprot id: O67236
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

224324:AQ RS00660
gene id: 224324:AQ_RS00660
uniprot id: O66548
names: Similarity
messages: Belongs to the Nudix hydrolase family.

224324:AQ RS00080
gene id: 224324:AQ_RS00080
uniprot id: O66442
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

224324:AQ RS05740
gene id: 224324:AQ_RS05740
uniprot id: O67444
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

224324:AQ RS01110
gene id: 224324:AQ_RS01110
uniprot id: O66630
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.

224324:AQ RS02675
gene id: 224324:AQ_RS02675
uniprot id: O66896
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

224324:AQ RS04565
gene id: 224324:AQ_RS04565
uniprot id: O67233
names: Caution
names: Cofactor
names: Domain
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: CarB is split into two genes in A.aeolicus (AQ_1172 and AQ_2101).
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Corresponds to the C-terminal section.

224324:AQ RS06775
gene id: 224324:AQ_RS06775
uniprot id: O67625
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
messages: Highly sensitive to dioxygen.
messages: Was shown to bind 1 [3Fe-4S] cluster per subunit (PubMed:19035630). However, it likely initially contains a [4Fe-4S] cluster which easily degrades into a [3Fe-4S] form in the presence of oxygen (By similarity).

224324:AQ RS06915
gene id: 224324:AQ_RS06915
uniprot id: O67644
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family. RnhC subfamily.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

224324:AQ RS03395
gene id: 224324:AQ_RS03395
uniprot id: O67028
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

224324:AQ RS05865
gene id: 224324:AQ_RS05865
uniprot id: O67465
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Binds two Mg(2+) per subunit.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

224324:AQ RS03965
gene id: 224324:AQ_RS03965
uniprot id: O67125
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the PolIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).

224324:AQ RS08510
gene id: 224324:AQ_RS08510
uniprot id: O67919
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form.

224324:AQ RS06525
gene id: 224324:AQ_RS06525
uniprot id: O67586
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

224324:AQ RS05655
gene id: 224324:AQ_RS05655
uniprot id: O67429
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

224324:AQ RS02960
gene id: 224324:AQ_RS02960
uniprot id: O66952
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FPP/GGPP synthase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm

224324:AQ RS06690
gene id: 224324:AQ_RS06690
uniprot id: O67612
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

224324:AQ RS08395
gene id: 224324:AQ_RS08395
uniprot id: O67899
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.
messages: The N-terminal domain contains the ATP/Pi binding site, the central domain the pyrophosphate/phosphate carrier histidine, and the C-terminal domain the pyruvate binding site.
messages: The reaction takes place in three steps, mediated by a phosphocarrier histidine residue located on the surface of the central domain. The two first partial reactions are catalyzed at an active site located on the N-terminal domain, and the third partial reaction is catalyzed at an active site located on the C-terminal domain. For catalytic turnover, the central domain swivels from the concave surface of the N-terminal domain to that of the C-terminal domain (By similarity).

224324:AQ RS00280
gene id: 224324:AQ_RS00280
uniprot id: O66480
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS07405
gene id: 224324:AQ_RS07405
uniprot id: O67727
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

224324:AQ RS03835
gene id: 224324:AQ_RS03835
uniprot id: O67099
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

224324:AQ RS07450
gene id: 224324:AQ_RS07450
uniprot id: O67736
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

224324:AQ RS00205
gene id: 224324:AQ_RS00205
uniprot id: O66465
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Homodimer.
messages: Inhibited by natural nucleoside antibiotics including tunicamycin, capuramycin and muraymycin. Usually the cofactor magnesium is not required for antibiotic binding.

224324:AQ RS01415
gene id: 224324:AQ_RS01415
uniprot id: O66680
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Seems to consist of an alpha chain and a beta chain.

224324:AQ RS05900
gene id: 224324:AQ_RS05900
uniprot id: O67470
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Binds 1 Fe cation per subunit.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.

224324:AQ RS04610
gene id: 224324:AQ_RS04610
uniprot id: O67242
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

224324:AQ RS02515
gene id: 224324:AQ_RS02515
uniprot id: O66874
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

224324:AQ RS06675
gene id: 224324:AQ_RS06675
uniprot id: O67609
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

224324:AQ RS04910
gene id: 224324:AQ_RS04910
uniprot id: O67295
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

224324:AQ RS04945
gene id: 224324:AQ_RS04945
uniprot id: O67301
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS06670
gene id: 224324:AQ_RS06670
uniprot id: O67608
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: Periplasm
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

224324:AQ RS06270
gene id: 224324:AQ_RS06270
uniprot id: O67541
names: Similarity
messages: Belongs to the UPF0758 family.

224324:AQ RS00125
gene id: 224324:AQ_RS00125
uniprot id: O66449
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS01665
gene id: 224324:AQ_RS01665
uniprot id: O66726
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

224324:AQ RS03915
gene id: 224324:AQ_RS03915
uniprot id: O67115
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS05385
gene id: 224324:AQ_RS05385
uniprot id: O67378
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

224324:AQ RS00805
gene id: 224324:AQ_RS00805
uniprot id: O66576
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

224324:AQ RS04330
gene id: 224324:AQ_RS04330
uniprot id: O67190
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

224324:AQ RS08590
gene id: 224324:AQ_RS08590
uniprot id: O67934
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

224324:AQ RS04045
gene id: 224324:AQ_RS04045
uniprot id: O67140
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

224324:AQ RS02010
gene id: 224324:AQ_RS02010
uniprot id: O66787
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

224324:AQ RS04955
gene id: 224324:AQ_RS04955
uniprot id: O67303
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS01515
gene id: 224324:AQ_RS01515
uniprot id: O66698
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS06370
gene id: 224324:AQ_RS06370
uniprot id: O67558
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

224324:AQ RS04460
gene id: 224324:AQ_RS04460
uniprot id: O67215
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

224324:AQ RS08545
gene id: 224324:AQ_RS08545
uniprot id: O67925
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

224324:AQ RS00460
gene id: 224324:AQ_RS00460
uniprot id: O66514
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.
messages: The activity of this enzyme could be controlled by adenylation under conditions of abundant glutamine.

224324:AQ RS07630
gene id: 224324:AQ_RS07630
uniprot id: O67762
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

224324:AQ RS06710
gene id: 224324:AQ_RS06710
uniprot id: O67615
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

224324:AQ RS06180
gene id: 224324:AQ_RS06180
uniprot id: O67526
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

224324:AQ RS05615
gene id: 224324:AQ_RS05615
uniprot id: O67421
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS00120
gene id: 224324:AQ_RS00120
uniprot id: O66448
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

224324:AQ RS05325
gene id: 224324:AQ_RS05325
uniprot id: O67368
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

224324:AQ RS00265
gene id: 224324:AQ_RS00265
uniprot id: O66477
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

224324:AQ RS03610
gene id: 224324:AQ_RS03610
uniprot id: O67062
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS01695
gene id: 224324:AQ_RS01695
uniprot id: O66732
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

224324:AQ RS01000
gene id: 224324:AQ_RS01000
uniprot id: O66614
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

224324:AQ RS07795
gene id: 224324:AQ_RS07795
uniprot id: O67791
names: Function
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily. FBPase class 4 family.
messages: Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, and both D and L isomers of inositol-1-phosphate (I-1-P).

224324:AQ RS03955
gene id: 224324:AQ_RS03955
uniprot id: O67123
names: Similarity
messages: Belongs to the CutA family.

224324:AQ RS07545
gene id: 224324:AQ_RS07545
uniprot id: O67751
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.

224324:AQ RS05210
gene id: 224324:AQ_RS05210
uniprot id: O67349
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS00700
gene id: 224324:AQ_RS00700
uniprot id: O66557
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS00065
gene id: 224324:AQ_RS00065
uniprot id: O66439
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

224324:AQ RS03085
gene id: 224324:AQ_RS03085
uniprot id: O66976
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

224324:AQ RS02870
gene id: 224324:AQ_RS02870
uniprot id: O66935
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

224324:AQ RS08635
gene id: 224324:AQ_RS08635
uniprot id: O67943
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

224324:AQ RS07105
gene id: 224324:AQ_RS07105
uniprot id: O67678
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS02275
gene id: 224324:AQ_RS02275
uniprot id: O66832
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS06485
gene id: 224324:AQ_RS06485
uniprot id: O67578
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

224324:AQ RS02940
gene id: 224324:AQ_RS02940
uniprot id: O66948
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Cell membrane

224324:AQ RS00570
gene id: 224324:AQ_RS00570
uniprot id: O66533
names: Cofactor
names: PTM
names: Subcellular Location Annotation
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.
messages: Periplasm

224324:AQ RS04505
gene id: 224324:AQ_RS04505
uniprot id: O67223
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

224324:AQ RS03770
gene id: 224324:AQ_RS03770
uniprot id: O67088
names: Similarity
messages: Belongs to the peptidase S26 family.

224324:AQ RS04190
gene id: 224324:AQ_RS04190
uniprot id: O67165
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

224324:AQ RS04205
gene id: 224324:AQ_RS04205
uniprot id: O67168
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS01860
gene id: 224324:AQ_RS01860
uniprot id: O66761
names: Cofactor
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

224324:AQ RS06850
gene id: 224324:AQ_RS06850
uniprot id: O67635
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

224324:AQ RS01180
gene id: 224324:AQ_RS01180
uniprot id: O66644
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

224324:AQ RS06995
gene id: 224324:AQ_RS06995
uniprot id: O67657
names: Similarity
messages: Belongs to the TrpC family.

224324:AQ RS01375
gene id: 224324:AQ_RS01375
uniprot id: O66674
names: Function
names: Similarity
messages: Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity).
messages: Belongs to the arsA ATPase family.

224324:AQ RS00500
gene id: 224324:AQ_RS00500
uniprot id: O66520
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

224324:AQ RS00970
gene id: 224324:AQ_RS00970
uniprot id: O66608
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

224324:AQ RS07315
gene id: 224324:AQ_RS07315
uniprot id: O67713
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

224324:AQ RS03200
gene id: 224324:AQ_RS03200
uniprot id: O66997
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

224324:AQ RS05435
gene id: 224324:AQ_RS05435
uniprot id: O67389
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS05405
gene id: 224324:AQ_RS05405
uniprot id: O67382
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

224324:AQ RS04430
gene id: 224324:AQ_RS04430
uniprot id: O67209
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

224324:AQ RS03725
gene id: 224324:AQ_RS03725
uniprot id: O67080
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

224324:AQ RS02925
gene id: 224324:AQ_RS02925
uniprot id: O66945
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

224324:AQ RS02665
gene id: 224324:AQ_RS02665
uniprot id: O66894
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

224324:AQ RS08300
gene id: 224324:AQ_RS08300
uniprot id: O67882
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS04615
gene id: 224324:AQ_RS04615
uniprot id: O67243
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each (By similarity).

224324:AQ RS07790
gene id: 224324:AQ_RS07790
uniprot id: O67790
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS04640
gene id: 224324:AQ_RS04640
uniprot id: O67248
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS04590
gene id: 224324:AQ_RS04590
uniprot id: O67238
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

224324:AQ RS07895
gene id: 224324:AQ_RS07895
uniprot id: O67810
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

224324:AQ RS06755
gene id: 224324:AQ_RS06755
uniprot id: O67621
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

224324:AQ RS04740
gene id: 224324:AQ_RS04740
uniprot id: O67266
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Cell membrane
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum (By similarity).

224324:AQ RS07625
gene id: 224324:AQ_RS07625
uniprot id: P0A466
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

224324:AQ RS03425
gene id: 224324:AQ_RS03425
uniprot id: P58413
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

224324:AQ RS02335
gene id: 224324:AQ_RS02335
uniprot id: O66842
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).

224324:AQ RS03890
gene id: 224324:AQ_RS03890
uniprot id: O67110
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

224324:AQ RS03105
gene id: 224324:AQ_RS03105
uniprot id: O66979
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

224324:AQ RS04020
gene id: 224324:AQ_RS04020
uniprot id: O67135
names: Similarity
messages: Belongs to the histone deacetylase family.

224324:AQ RS00330
gene id: 224324:AQ_RS00330
uniprot id: O66489
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

224324:AQ RS01740
gene id: 224324:AQ_RS01740
uniprot id: O66740
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

224324:AQ RS07555
gene id: 224324:AQ_RS07555
uniprot id: O67753
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS08580
gene id: 224324:AQ_RS08580
uniprot id: O67932
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

224324:AQ RS03440
gene id: 224324:AQ_RS03440
uniprot id: O67033
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

224324:AQ RS00005
gene id: 224324:AQ_RS00005
uniprot id: O66428
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
messages: Cytoplasm

224324:AQ RS08405
gene id: 224324:AQ_RS08405
uniprot id: O67901
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS06190
gene id: 224324:AQ_RS06190
uniprot id: O67528
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

224324:AQ RS03785
gene id: 224324:AQ_RS03785
uniprot id: O67091
names: Function
names: Similarity
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.

224324:AQ RS02310
gene id: 224324:AQ_RS02310
uniprot id: O66838
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein S18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

224324:AQ RS05155
gene id: 224324:AQ_RS05155
uniprot id: O67338
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

224324:AQ RS00070
gene id: 224324:AQ_RS00070
uniprot id: O66440
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

224324:AQ RS07720
gene id: 224324:AQ_RS07720
uniprot id: O67779
names: Similarity
messages: Belongs to the DNA polymerase type-A family.

224324:AQ RS00180
gene id: 224324:AQ_RS00180
uniprot id: O66460
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

224324:AQ RS04305
gene id: 224324:AQ_RS04305
uniprot id: O67185
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

224324:AQ RS04420
gene id: 224324:AQ_RS04420
uniprot id: O67207
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

224324:AQ RS04010
gene id: 224324:AQ_RS04010
uniprot id: O67133
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

224324:AQ RS04875
gene id: 224324:AQ_RS04875
uniprot id: O67289
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

224324:AQ RS07865
gene id: 224324:AQ_RS07865
uniprot id: O67805
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity).
messages: Secreted

224324:AQ RS02215
gene id: 224324:AQ_RS02215
uniprot id: O66821
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.

224324:AQ RS07655
gene id: 224324:AQ_RS07655
uniprot id: O67767
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

224324:AQ RS07695
gene id: 224324:AQ_RS07695
uniprot id: O67774
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Role in flagellar biosynthesis.

224324:AQ RS04995
gene id: 224324:AQ_RS04995
uniprot id: O67308
names: Similarity
messages: Belongs to the peptidase M16 family.

224324:AQ RS02910
gene id: 224324:AQ_RS02910
uniprot id: O66943
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).

224324:AQ RS08355
gene id: 224324:AQ_RS08355
uniprot id: O67891
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

224324:AQ RS00895
gene id: 224324:AQ_RS00895
uniprot id: O66594
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

224324:AQ RS07465
gene id: 224324:AQ_RS07465
uniprot id: O67739
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity).

224324:AQ RS04150
gene id: 224324:AQ_RS04150
uniprot id: O67160
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS04030
gene id: 224324:AQ_RS04030
uniprot id: O67137
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase. Despite its similarity to DNA gyrase, this enzyme is not able to supercoil DNA, and instead acts like topoisomerase IV. Relaxes both positively and negatively supercoiled DNA in an ATP-dependent fashion, decatenates interlocked circles. If this subunit is reconstituted with GyrA from E.coli the hybrid enzyme supercoils relaxed plasmid DNA; if paired with E.coli ParC supercoiling is not restored. This the first bacteria shown to not contain DNA gyrase, although it has 2 copies of a reverse gyrase that introduces positive supercoils. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner (PubMed:21076033).
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, 'GyrA' contains the active site tyrosine that forms a transient covalent intermediate with DNA, while 'GyrB' binds cofactors and catalyzes ATP hydrolysis (PubMed:21076033).

224324:AQ RS05755
gene id: 224324:AQ_RS05755
uniprot id: O67447
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

224324:AQ RS00375
gene id: 224324:AQ_RS00375
uniprot id: O66497
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

224324:AQ RS03040
gene id: 224324:AQ_RS03040
uniprot id: O66968
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

224324:AQ RS07485
gene id: 224324:AQ_RS07485
uniprot id: O67743
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

224324:AQ RS03560
gene id: 224324:AQ_RS03560
uniprot id: O67053
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake. In this role, it may bind, possibly as a chaperone, to PhoR, PhoB or a PhoR-PhoB complex to promote dephosphorylation of phospho-PhoB, or inhibit formation of the PhoR-PhoB transitory complex (Probable).

224324:AQ RS03030
gene id: 224324:AQ_RS03030
uniprot id: O66966
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS01485
gene id: 224324:AQ_RS01485
uniprot id: O66692
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

224324:AQ RS08365
gene id: 224324:AQ_RS08365
uniprot id: O67893
names: Cofactor
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.

224324:AQ RS08805
gene id: 224324:AQ_RS08805
uniprot id: O66414
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS05000
gene id: 224324:AQ_RS05000
uniprot id: O67309
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

224324:AQ RS03760
gene id: 224324:AQ_RS03760
uniprot id: O67086
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity).

224324:AQ RS04915
gene id: 224324:AQ_RS04915
uniprot id: O67296
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

224324:AQ RS05620
gene id: 224324:AQ_RS05620
uniprot id: O67422
names: Function
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.
messages: Catalyzes the NADH-dependent reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. Is required to provide the methyl group necessary for methionine synthetase to convert homocysteine to methionine; the methyl group is given by 5-methyltetrahydrofolate.

224324:AQ RS05105
gene id: 224324:AQ_RS05105
uniprot id: O67328
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

224324:AQ RS06185
gene id: 224324:AQ_RS06185
uniprot id: O67527
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

224324:AQ RS05160
gene id: 224324:AQ_RS05160
uniprot id: O67339
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

224324:AQ RS08320
gene id: 224324:AQ_RS08320
uniprot id: O67886
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
messages: Monomer.

224324:AQ RS07000
gene id: 224324:AQ_RS07000
uniprot id: O67658
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.

224324:AQ RS08455
gene id: 224324:AQ_RS08455
uniprot id: O67909
names: Similarity
messages: Belongs to the RecJ family.

224324:AQ RS07400
gene id: 224324:AQ_RS07400
uniprot id: O67726
names: Similarity
messages: Belongs to the LOG family.

224324:AQ RS02200
gene id: 224324:AQ_RS02200
uniprot id: O66819
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane

224324:AQ RS01215
gene id: 224324:AQ_RS01215
uniprot id: O66651
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

224324:AQ RS01445
gene id: 224324:AQ_RS01445
uniprot id: O66686
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

224324:AQ RS02390
gene id: 224324:AQ_RS02390
uniprot id: O66852
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

224324:AQ RS02930
gene id: 224324:AQ_RS02930
uniprot id: O66946
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

224324:AQ RS01090
gene id: 224324:AQ_RS01090
uniprot id: O66626
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.
messages: The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit (By similarity).

224324:AQ RS00455
gene id: 224324:AQ_RS00455
uniprot id: O66513
names: Function
names: Similarity
names: Subunit
messages: Belongs to the P(II) protein family.
messages: Homotrimer.
messages: In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed (By similarity).

224324:AQ RS05690
gene id: 224324:AQ_RS05690
uniprot id: O67435
names: Similarity
messages: Belongs to the Nudix hydrolase family.

224324:AQ RS00220
gene id: 224324:AQ_RS00220
uniprot id: O66468
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

224324:AQ RS04495
gene id: 224324:AQ_RS04495
uniprot id: O67221
names: Similarity
messages: Belongs to the aspartokinase family.

224324:AQ RS00275
gene id: 224324:AQ_RS00275
uniprot id: O66479
names: Domain
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: The C-terminal region is probably involved in protein stability.

224324:AQ RS02165
gene id: 224324:AQ_RS02165
uniprot id: O66812
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

224324:AQ RS01520
gene id: 224324:AQ_RS01520
uniprot id: O66699
names: Similarity
messages: To A.fulgidus AF1864.

224324:AQ RS02990
gene id: 224324:AQ_RS02990
uniprot id: O66958
names: Similarity
messages: Belongs to the UPF0128 family.

224324:AQ RS07180
gene id: 224324:AQ_RS07180
uniprot id: O70089
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

224324:AQ RS04060
gene id: 224324:AQ_RS04060
uniprot id: O67144
names: Similarity
messages: Belongs to the transposase 27 family.

224324:AQ RS06355
gene id: 224324:AQ_RS06355
uniprot id: O67556
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

224324:AQ RS04270
gene id: 224324:AQ_RS04270
uniprot id: O67180
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

224324:AQ RS04185
gene id: 224324:AQ_RS04185
uniprot id: O67164
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

224324:AQ RS06685
gene id: 224324:AQ_RS06685
uniprot id: O67611
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

224324:AQ RS01220
gene id: 224324:AQ_RS01220
uniprot id: O66652
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity).

224324:AQ RS05890
gene id: 224324:AQ_RS05890
uniprot id: O67469
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF nuclease family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

224324:AQ RS00795
gene id: 224324:AQ_RS00795
uniprot id: O66574
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

224324:AQ RS08040
gene id: 224324:AQ_RS08040
uniprot id: O67838
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS00860
gene id: 224324:AQ_RS00860
uniprot id: O66587
names: Function
names: Similarity
messages: Belongs to the cyanase family.
messages: Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.

224324:AQ RS06055
gene id: 224324:AQ_RS06055
uniprot id: O67501
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

224324:AQ RS04605
gene id: 224324:AQ_RS04605
uniprot id: O67241
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Cell inner membrane
messages: The M ring may be actively involved in energy transduction.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively (By similarity).

224324:AQ RS00305
gene id: 224324:AQ_RS00305
uniprot id: O66484
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

224324:AQ RS06640
gene id: 224324:AQ_RS06640
uniprot id: O67602
names: Similarity
messages: Belongs to the UDPGP type 2 family.

224324:AQ RS06330
gene id: 224324:AQ_RS06330
uniprot id: O67551
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

224324:AQ RS00030
gene id: 224324:AQ_RS00030
uniprot id: O66433
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

224324:AQ RS04865
gene id: 224324:AQ_RS04865
uniprot id: O67287
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

224324:AQ RS06680
gene id: 224324:AQ_RS06680
uniprot id: O67610
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

224324:AQ RS01395
gene id: 224324:AQ_RS01395
uniprot id: O66677
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

224324:AQ RS05840
gene id: 224324:AQ_RS05840
uniprot id: O67460
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

224324:AQ RS00680
gene id: 224324:AQ_RS00680
uniprot id: O66552
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity).

224324:AQ RS06655
gene id: 224324:AQ_RS06655
uniprot id: O67605
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.

224324:AQ RS07740
gene id: 224324:AQ_RS07740
uniprot id: O67782
names: Similarity
messages: Belongs to the GSP E family.

224324:AQ RS07890
gene id: 224324:AQ_RS07890
uniprot id: O67809
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

224324:AQ RS08295
gene id: 224324:AQ_RS08295
uniprot id: O67881
names: Similarity
messages: Belongs to the SAICAR synthetase family.

224324:AQ RS01195
gene id: 224324:AQ_RS01195
uniprot id: O66647
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

224324:AQ RS08330
gene id: 224324:AQ_RS08330
uniprot id: O67888
names: Similarity
messages: Belongs to the archease family.

224324:AQ RS03025
gene id: 224324:AQ_RS03025
uniprot id: O66965
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS06175
gene id: 224324:AQ_RS06175
uniprot id: O67525
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

224324:AQ RS04455
gene id: 224324:AQ_RS04455
uniprot id: O67214
names: Function
names: Similarity
messages: Belongs to the MDIP synthase family.
messages: Catalyzes the transfer of the mannosyl group from GDP-mannose to di-myo-inositol-1,3'-phosphate (DIP), producing mannosyl-di-myo-inositol phosphate (MDIP) (PubMed:19648237). Can also use MDIP as an acceptor of a second mannose residue, yielding di-mannosyl-di-myo-inositol phosphate (MMDIP) (By similarity).

224324:AQ RS07600
gene id: 224324:AQ_RS07600
uniprot id: D0VWU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with SecDF, and other proteins may be involved. The channel interacts with SecA via subunit SecY.
messages: Essential subunit of the protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

224324:AQ RS06545
gene id: 224324:AQ_RS06545
uniprot id: O67589
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS05565
gene id: 224324:AQ_RS05565
uniprot id: O67411
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

224324:AQ RS05250
gene id: 224324:AQ_RS05250
uniprot id: O67356
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

224324:AQ RS06970
gene id: 224324:AQ_RS06970
uniprot id: O67653
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

224324:AQ RS04730
gene id: 224324:AQ_RS04730
uniprot id: O67264
names: Similarity
messages: To A.aeolicus aq_820 and aq_1583.

224324:AQ RS02150
gene id: 224324:AQ_RS02150
uniprot id: O66810
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.
messages: In the N-terminal section; belongs to the MoaC family.

224324:AQ RS01975
gene id: 224324:AQ_RS01975
uniprot id: O66779
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm

224324:AQ RS05270
gene id: 224324:AQ_RS05270
uniprot id: O67359
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Homodimer.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate.

224324:AQ RS01080
gene id: 224324:AQ_RS01080
uniprot id: O66624
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS01955
gene id: 224324:AQ_RS01955
uniprot id: O66777
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

224324:AQ RS00735
gene id: 224324:AQ_RS00735
uniprot id: O66562
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

224324:AQ RS04315
gene id: 224324:AQ_RS04315
uniprot id: O67187
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

224324:AQ RS03255
gene id: 224324:AQ_RS03255
uniprot id: O67003
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

224324:AQ RS05810
gene id: 224324:AQ_RS05810
uniprot id: O67455
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

224324:AQ RS01935
gene id: 224324:AQ_RS01935
uniprot id: O66773
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

224324:AQ RS07810
gene id: 224324:AQ_RS07810
uniprot id: O67794
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

224324:AQ RS07745
gene id: 224324:AQ_RS07745
uniprot id: O67783
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

224324:AQ RS01855
gene id: 224324:AQ_RS01855
uniprot id: O66760
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS02285
gene id: 224324:AQ_RS02285
uniprot id: O66834
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

224324:AQ RS02935
gene id: 224324:AQ_RS02935
uniprot id: O66947
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

224324:AQ RS07340
gene id: 224324:AQ_RS07340
uniprot id: O67716
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.

224324:AQ RS03450
gene id: 224324:AQ_RS03450
uniprot id: O67035
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HARP family.
messages: Probably forms homotrimers.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

224324:AQ RS01095
gene id: 224324:AQ_RS01095
uniprot id: O66627
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

224324:AQ RS01495
gene id: 224324:AQ_RS01495
uniprot id: O66694
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

224324:AQ RS06420
gene id: 224324:AQ_RS06420
uniprot id: O67566
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

224324:AQ RS06760
gene id: 224324:AQ_RS06760
uniprot id: O67622
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

224324:AQ RS06170
gene id: 224324:AQ_RS06170
uniprot id: O67524
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS07725
gene id: 224324:AQ_RS07725
uniprot id: O67780
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

224324:AQ RS02650
gene id: 224324:AQ_RS02650
uniprot id: O66893
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Binds two Mg(2+) per subunit.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

224324:AQ RS01830
gene id: 224324:AQ_RS01830
uniprot id: O66756
names: Similarity
messages: Belongs to the UPF0166 family.

224324:AQ RS07920
gene id: 224324:AQ_RS07920
uniprot id: O67815
names: Similarity
messages: Belongs to the PstS family.

224324:AQ RS08025
gene id: 224324:AQ_RS08025
uniprot id: O67835
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

224324:AQ RS00990
gene id: 224324:AQ_RS00990
uniprot id: O66612
names: Function
names: Similarity
messages: Belongs to the type-2 OGG1 family.
messages: Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).

224324:AQ RS06950
gene id: 224324:AQ_RS06950
uniprot id: O67650
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

224324:AQ RS00865
gene id: 224324:AQ_RS00865
uniprot id: O66588
names: Similarity
messages: Belongs to the P(II) protein family.

224324:AQ RS02125
gene id: 224324:AQ_RS02125
uniprot id: O66805
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

224324:AQ RS08125
gene id: 224324:AQ_RS08125
uniprot id: O67853
names: Similarity
messages: Belongs to the TrpF family.

224324:AQ RS03420
gene id: 224324:AQ_RS03420
uniprot id: O67031
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.

224324:AQ RS04115
gene id: 224324:AQ_RS04115
uniprot id: O67154
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

224324:AQ RS03295
gene id: 224324:AQ_RS03295
uniprot id: O67011
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity).

224324:AQ RS06550
gene id: 224324:AQ_RS06550
uniprot id: O67590
names: Similarity
messages: Belongs to the class-I fumarase family.

224324:AQ RS03930
gene id: 224324:AQ_RS03930
uniprot id: O67118
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock (By similarity).

224324:AQ RS03745
gene id: 224324:AQ_RS03745
uniprot id: O67083
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

224324:AQ RS03015
gene id: 224324:AQ_RS03015
uniprot id: O66963
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
messages: Homodimer.

224324:AQ RS01115
gene id: 224324:AQ_RS01115
uniprot id: O66631
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

224324:AQ RS01270
gene id: 224324:AQ_RS01270
uniprot id: O66659
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).

224324:AQ RS02455
gene id: 224324:AQ_RS02455
uniprot id: O66863
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

224324:AQ RS08620
gene id: 224324:AQ_RS08620
uniprot id: O67940
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

224324:AQ RS06115
gene id: 224324:AQ_RS06115
uniprot id: O67513
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS08430
gene id: 224324:AQ_RS08430
uniprot id: O67904
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

224324:AQ RS06300
gene id: 224324:AQ_RS06300
uniprot id: O67547
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

224324:AQ RS03535
gene id: 224324:AQ_RS03535
uniprot id: O67049
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: AroE is dependent on the hydrogen ion concentration of the environment. A low pH environment favors the formation of SA and NADP, whereas a high pH condition favors the formation of DHSA and NADPH.
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

224324:AQ RS04575
gene id: 224324:AQ_RS04575
uniprot id: O67235
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RlpA family.
messages: Cell membrane
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

224324:AQ RS07125
gene id: 224324:AQ_RS07125
uniprot id: O67682
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS02005
gene id: 224324:AQ_RS02005
uniprot id: O66786
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

224324:AQ RS03210
gene id: 224324:AQ_RS03210
uniprot id: O66999
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS05850
gene id: 224324:AQ_RS05850
uniprot id: O67462
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.

224324:AQ RS04365
gene id: 224324:AQ_RS04365
uniprot id: O67195
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

224324:AQ RS01650
gene id: 224324:AQ_RS01650
uniprot id: O66723
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS01900
gene id: 224324:AQ_RS01900
uniprot id: O66768
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

224324:AQ RS00640
gene id: 224324:AQ_RS00640
uniprot id: O66544
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell inner membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.

224324:AQ RS05245
gene id: 224324:AQ_RS05245
uniprot id: O67355
names: Similarity
messages: Belongs to the MEMO1 family.

224324:AQ RS08120
gene id: 224324:AQ_RS08120
uniprot id: O67852
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

224324:AQ RS04395
gene id: 224324:AQ_RS04395
uniprot id: O67202
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

224324:AQ RS05335
gene id: 224324:AQ_RS05335
uniprot id: O67370
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

224324:AQ RS06650
gene id: 224324:AQ_RS06650
uniprot id: O67604
names: Function
names: Subunit
messages: Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.
messages: Homotrimer.

224324:AQ RS00175
gene id: 224324:AQ_RS00175
uniprot id: O66459
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS07535
gene id: 224324:AQ_RS07535
uniprot id: O67750
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Plays a role in the flagellum-specific transport system.

224324:AQ RS03365
gene id: 224324:AQ_RS03365
uniprot id: O67023
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

224324:AQ RS03060
gene id: 224324:AQ_RS03060
uniprot id: O66971
names: Similarity
messages: Belongs to the TlyA family.

224324:AQ RS05120
gene id: 224324:AQ_RS05120
uniprot id: O67331
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

224324:AQ RS05350
gene id: 224324:AQ_RS05350
uniprot id: O67373
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

224324:AQ RS04180
gene id: 224324:AQ_RS04180
uniprot id: O67163
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

224324:AQ RS04735
gene id: 224324:AQ_RS04735
uniprot id: O67265
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin (By similarity).

224324:AQ RS07685
gene id: 224324:AQ_RS07685
uniprot id: O67772
names: Function
names: Similarity
messages: Belongs to the ThiD family.
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.

224324:AQ RS05125
gene id: 224324:AQ_RS05125
uniprot id: O67332
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

224324:AQ RS00580
gene id: 224324:AQ_RS00580
uniprot id: O66535
names: Similarity
messages: Belongs to the ribF family.

224324:AQ RS04160
gene id: 224324:AQ_RS04160
uniprot id: O67162
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Monomer.

224324:AQ RS08465
gene id: 224324:AQ_RS08465
uniprot id: O67911
names: Domain
names: Function
names: Similarity
messages: Adopts a seahorse-like shape and consists of four domains: head, neck, body, and tail.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
messages: tRNA nucleotidyltransferase involved in the synthesis of the tRNA CCA terminus. Adds the two cytidine residues to tRNA.

224324:AQ RS03630
gene id: 224324:AQ_RS03630
uniprot id: O67066
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

224324:AQ RS07380
gene id: 224324:AQ_RS07380
uniprot id: O67723
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

224324:AQ RS05365
gene id: 224324:AQ_RS05365
uniprot id: O67376
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).

224324:AQ RS00420
gene id: 224324:AQ_RS00420
uniprot id: O66507
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS03415
gene id: 224324:AQ_RS03415
uniprot id: O67030
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

224324:AQ RS02025
gene id: 224324:AQ_RS02025
uniprot id: O66790
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: The active site is a redox-active disulfide bond.

224324:AQ RS00315
gene id: 224324:AQ_RS00315
uniprot id: O66486
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

224324:AQ RS01420
gene id: 224324:AQ_RS01420
uniprot id: O66681
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Membrane

224324:AQ RS07190
gene id: 224324:AQ_RS07190
uniprot id: O67692
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

224324:AQ RS04920
gene id: 224324:AQ_RS04920
uniprot id: O67297
names: Similarity
messages: Belongs to the OprB family.

224324:AQ RS00140
gene id: 224324:AQ_RS00140
uniprot id: O66452
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

224324:AQ RS07185
gene id: 224324:AQ_RS07185
uniprot id: O67691
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

224324:AQ RS03605
gene id: 224324:AQ_RS03605
uniprot id: O67061
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

224324:AQ RS06885
gene id: 224324:AQ_RS06885
uniprot id: O67641
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

224324:AQ RS04235
gene id: 224324:AQ_RS04235
uniprot id: O67174
names: Similarity
messages: In the C-terminal section; belongs to the APS kinase family.
messages: In the N-terminal section; belongs to the sulfate adenylyltransferase family.

224324:AQ RS02330
gene id: 224324:AQ_RS02330
uniprot id: O66841
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: Binds 1 FMN.
messages: Binds 1 [4Fe-4S] cluster.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).

224324:AQ RS04025
gene id: 224324:AQ_RS04025
uniprot id: O67136
names: Similarity
messages: Belongs to the universal stress protein A family.

224324:AQ RS07210
gene id: 224324:AQ_RS07210
uniprot id: O67695
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2 (By similarity).
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

224324:AQ RS03565
gene id: 224324:AQ_RS03565
uniprot id: O67054
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

224324:AQ RS07165
gene id: 224324:AQ_RS07165
uniprot id: O67689
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

224324:AQ RS08480
gene id: 224324:AQ_RS08480
uniprot id: O67914
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

224324:AQ RS08115
gene id: 224324:AQ_RS08115
uniprot id: O67851
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS07005
gene id: 224324:AQ_RS07005
uniprot id: O67659
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

224324:AQ RS03960
gene id: 224324:AQ_RS03960
uniprot id: O67124
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a complex with Mre11 (By similarity).
messages: Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site (By similarity).
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer (By similarity).

224324:AQ RS00965
gene id: 224324:AQ_RS00965
uniprot id: O66607
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity).
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS06230
gene id: 224324:AQ_RS06230
uniprot id: O67535
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

224324:AQ RS00465
gene id: 224324:AQ_RS00465
uniprot id: O66515
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Homotrimer.
messages: Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)).

224324:AQ RS01470
gene id: 224324:AQ_RS01470
uniprot id: O66690
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS04465
gene id: 224324:AQ_RS04465
uniprot id: O67216
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

224324:AQ RS00215
gene id: 224324:AQ_RS00215
uniprot id: O66467
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS04325
gene id: 224324:AQ_RS04325
uniprot id: O67189
names: Similarity
messages: To R.prowazekii RP189.

224324:AQ RS06275
gene id: 224324:AQ_RS06275
uniprot id: O67542
names: Similarity
messages: Belongs to the UbiD family.

224324:AQ RS05025
gene id: 224324:AQ_RS05025
uniprot id: O67314
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

224324:AQ RS03860
gene id: 224324:AQ_RS03860
uniprot id: O67104
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

224324:AQ RS08020
gene id: 224324:AQ_RS08020
uniprot id: O67834
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

224324:AQ RS00885
gene id: 224324:AQ_RS00885
uniprot id: O66592
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

224324:AQ RS04830
gene id: 224324:AQ_RS04830
uniprot id: O67281
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS03475
gene id: 224324:AQ_RS03475
uniprot id: O67039
names: Similarity
messages: Belongs to the MEMO1 family.

224324:AQ RS02720
gene id: 224324:AQ_RS02720
uniprot id: O66905
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

224324:AQ RS01335
gene id: 224324:AQ_RS01335
uniprot id: O66669
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

224324:AQ RS08130
gene id: 224324:AQ_RS08130
uniprot id: O67854
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS06465
gene id: 224324:AQ_RS06465
uniprot id: O67575
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BioW family.
messages: Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
messages: Homodimer.

224324:AQ RS06255
gene id: 224324:AQ_RS06255
uniprot id: O67539
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

224324:AQ RS08205
gene id: 224324:AQ_RS08205
uniprot id: O67865
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.

224324:AQ RS05310
gene id: 224324:AQ_RS05310
uniprot id: O67365
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cell membrane
messages: Homodimer or homotetramer.

224324:AQ RS08015
gene id: 224324:AQ_RS08015
uniprot id: O67833
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

224324:AQ RS01030
gene id: 224324:AQ_RS01030
uniprot id: O66618
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

224324:AQ RS00010
gene id: 224324:AQ_RS00010
uniprot id: O66429
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

224324:AQ RS01675
gene id: 224324:AQ_RS01675
uniprot id: O66728
names: Domain
names: Function
names: Similarity
messages: Adopts a seahorse-like shape and consists of four domains: head, neck, body, and tail.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
messages: tRNA nucleotidyltransferase involved in the synthesis of the tRNA CCA terminus. Adds the terminal adenosine residue to tRNA (PubMed:11701927, PubMed:25914059). Can incorporate CMP into tRNA ending with C74C75 (tRNACC), with very weak efficiency (PubMed:25914059).

224324:AQ RS04140
gene id: 224324:AQ_RS04140
uniprot id: O67158
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

224324:AQ RS01285
gene id: 224324:AQ_RS01285
uniprot id: O66662
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

224324:AQ RS00185
gene id: 224324:AQ_RS00185
uniprot id: O66461
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS05650
gene id: 224324:AQ_RS05650
uniprot id: O67428
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS07075
gene id: 224324:AQ_RS07075
uniprot id: O67672
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS06020
gene id: 224324:AQ_RS06020
uniprot id: O67494
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

224324:AQ RS08000
gene id: 224324:AQ_RS08000
uniprot id: O67830
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

224324:AQ RS08550
gene id: 224324:AQ_RS08550
uniprot id: O67926
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

224324:AQ RS02450
gene id: 224324:AQ_RS02450
uniprot id: O66862
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

224324:AQ RS06280
gene id: 224324:AQ_RS06280
uniprot id: O67543
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

224324:AQ RS08350
gene id: 224324:AQ_RS08350
uniprot id: O67890
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

224324:AQ RS01035
gene id: 224324:AQ_RS01035
uniprot id: O66619
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

224324:AQ RS06750
gene id: 224324:AQ_RS06750
uniprot id: O67620
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

224324:AQ RS02065
gene id: 224324:AQ_RS02065
uniprot id: O66797
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS00720
gene id: 224324:AQ_RS00720
uniprot id: O66559
names: Similarity
messages: Belongs to the Nth/MutY family.

224324:AQ RS03735
gene id: 224324:AQ_RS03735
uniprot id: O67081
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

224324:AQ RS06345
gene id: 224324:AQ_RS06345
uniprot id: O67554
names: Cofactor
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

224324:AQ RS06440
gene id: 224324:AQ_RS06440
uniprot id: O67570
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

224324:AQ RS07985
gene id: 224324:AQ_RS07985
uniprot id: O67827
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS02700
gene id: 224324:AQ_RS02700
uniprot id: O66901
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

224324:AQ RS06660
gene id: 224324:AQ_RS06660
uniprot id: O67606
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

224324:AQ RS06695
gene id: 224324:AQ_RS06695
uniprot id: O67613
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

224324:AQ RS01280
gene id: 224324:AQ_RS01280
uniprot id: O66661
names: Similarity
messages: Belongs to the sulfiredoxin family.

224324:AQ RS08200
gene id: 224324:AQ_RS08200
uniprot id: O67864
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

224324:AQ RS05855
gene id: 224324:AQ_RS05855
uniprot id: O67463
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

224324:AQ RS01885
gene id: 224324:AQ_RS01885
uniprot id: O66766
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

224324:AQ RS06220
gene id: 224324:AQ_RS06220
uniprot id: O67533
names: Function
names: Similarity
messages: Belongs to the Dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

224324:AQ RS06080
gene id: 224324:AQ_RS06080
uniprot id: O67506
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

224324:AQ RS00055
gene id: 224324:AQ_RS00055
uniprot id: O66438
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

224324:AQ RS04715
gene id: 224324:AQ_RS04715
uniprot id: O67261
names: Similarity
messages: Belongs to the Fur family.

224324:AQ RS02260
gene id: 224324:AQ_RS02260
uniprot id: O66829
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

224324:AQ RS07280
gene id: 224324:AQ_RS07280
uniprot id: O67707
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

224324:AQ RS05320
gene id: 224324:AQ_RS05320
uniprot id: O67367
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

224324:AQ RS01635
gene id: 224324:AQ_RS01635
uniprot id: O66720
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

224324:AQ RS05135
gene id: 224324:AQ_RS05135
uniprot id: O67334
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).

224324:AQ RS02890
gene id: 224324:AQ_RS02890
uniprot id: O66939
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

224324:AQ RS00935
gene id: 224324:AQ_RS00935
uniprot id: O66601
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

224324:AQ RS00545
gene id: 224324:AQ_RS00545
uniprot id: O66529
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

224324:AQ RS06770
gene id: 224324:AQ_RS06770
uniprot id: O67624
names: Similarity
messages: Belongs to the CFA/CMAS family.

224324:AQ RS04075
gene id: 224324:AQ_RS04075
uniprot id: O67147
names: Cofactor
messages: Binds 4 [4Fe-4S] clusters per subunit.

224324:AQ RS08435
gene id: 224324:AQ_RS08435
uniprot id: O67905
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

224324:AQ RS08515
gene id: 224324:AQ_RS08515
uniprot id: O67920
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

224324:AQ RS02145
gene id: 224324:AQ_RS02145
uniprot id: O66809
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

224324:AQ RS03035
gene id: 224324:AQ_RS03035
uniprot id: O66967
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

224324:AQ RS03335
gene id: 224324:AQ_RS03335
uniprot id: O67017
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS02485
gene id: 224324:AQ_RS02485
uniprot id: O66868
names: Similarity
messages: To A.aeolicus aq_328.

224324:AQ RS08575
gene id: 224324:AQ_RS08575
uniprot id: O67931
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SQRD family.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone. Consecutive reaction cycles lead to the accumulation of a polysulfide product on the active site Cys residues; these products are released when they exceed a critical length, typically as cyclooctasulfur.
messages: Homotrimer.
messages: Membrane

224324:AQ RS00225
gene id: 224324:AQ_RS00225
uniprot id: O66469
names: Similarity
messages: Belongs to the SfsA family.

224324:AQ RS02415
gene id: 224324:AQ_RS02415
uniprot id: O66856
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
messages: Homooligomer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site (By similarity).

224324:AQ RS00875
gene id: 224324:AQ_RS00875
uniprot id: O66590
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.

224324:AQ RS00635
gene id: 224324:AQ_RS00635
uniprot id: O66543
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS00890
gene id: 224324:AQ_RS00890
uniprot id: O66593
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

224324:AQ RS04110
gene id: 224324:AQ_RS04110
uniprot id: O67153
names: Cofactor
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily.
messages: Binds 2 divalent metal cations.

224324:AQ RS00605
gene id: 224324:AQ_RS00605
uniprot id: O66539
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

224324:AQ RS05205
gene id: 224324:AQ_RS05205
uniprot id: O67348
names: Cofactor
messages: Binds 1 zinc ion per subunit.

224324:AQ RS02995
gene id: 224324:AQ_RS02995
uniprot id: O66959
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS06730
gene id: 224324:AQ_RS06730
uniprot id: O67619
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
messages: Cytoplasm

224324:AQ RS04620
gene id: 224324:AQ_RS04620
uniprot id: O67244
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity).
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod. In Gram-negative bacteria, at least four rings, L, P, S and M are present, whereas Gram-positive bacteria lack the L and P rings. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF build up the proximal portion of the rod with about 6 subunits each. Rod assembly occurs by export via the flagellum-specific pathway of its constituent proteins and by their incorporation into the rod structure in the probable order of FlgB, FlgC, FlgF and FlgG. Another protein, FliE, also assembles onto the stable rod structure (By similarity).

224324:AQ RS00260
gene id: 224324:AQ_RS00260
uniprot id: O66476
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

224324:AQ RS02015
gene id: 224324:AQ_RS02015
uniprot id: O66788
names: Similarity
messages: Belongs to the 6-phosphogluconate dehydrogenase family.

224324:AQ RS03540
gene id: 224324:AQ_RS03540
uniprot id: O67050
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

224324:AQ RS06450
gene id: 224324:AQ_RS06450
uniprot id: O67572
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

224324:AQ RS06980
gene id: 224324:AQ_RS06980
uniprot id: O67654
names: Similarity
messages: Belongs to the class-I fumarase family.

224324:AQ RS03385
gene id: 224324:AQ_RS03385
uniprot id: O67026
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
messages: Cell inner membrane
messages: Forms a complex with DabB.
messages: Part of an energy-coupled inorganic carbon pump.

224324:AQ RS04935
gene id: 224324:AQ_RS04935
uniprot id: O67299
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

224324:AQ RS00015
gene id: 224324:AQ_RS00015
uniprot id: O66430
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

224324:AQ RS00730
gene id: 224324:AQ_RS00730
uniprot id: O66561
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

224324:AQ RS06715
gene id: 224324:AQ_RS06715
uniprot id: O67616
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

224324:AQ RS05255
gene id: 224324:AQ_RS05255
uniprot id: O67357
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

224324:AQ RS05050
gene id: 224324:AQ_RS05050
uniprot id: O67318
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

224324:AQ RS01555
gene id: 224324:AQ_RS01555
uniprot id: O66705
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISPR system Cmr5 family.
messages: Cytoplasm

224324:AQ RS05845
gene id: 224324:AQ_RS05845
uniprot id: O67461
names: Function
names: Similarity
messages: Belongs to the bacterial histone-like protein family.
messages: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.

224324:AQ RS02550
gene id: 224324:AQ_RS02550
uniprot id: O66880
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Manganese or magnesium. Has higher activity with manganese.

224324:AQ RS08215
gene id: 224324:AQ_RS08215
uniprot id: O67867
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

224324:AQ RS05445
gene id: 224324:AQ_RS05445
uniprot id: O67391
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

224324:AQ RS02520
gene id: 224324:AQ_RS02520
uniprot id: O66875
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

224324:AQ RS00760
gene id: 224324:AQ_RS00760
uniprot id: O66567
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).

224324:AQ RS05080
gene id: 224324:AQ_RS05080
uniprot id: O67323
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs. The Aquifex aeolicus domain can be used in vitro to replace the corresponding domain in E.coli.
messages: Cytoplasm

224324:AQ RS02955
gene id: 224324:AQ_RS02955
uniprot id: O66951
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

224324:AQ RS06435
gene id: 224324:AQ_RS06435
uniprot id: O67569
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

224324:AQ RS07070
gene id: 224324:AQ_RS07070
uniprot id: O67671
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

224324:AQ RS01920
gene id: 224324:AQ_RS01920
uniprot id: O66772
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. MtaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Cytoplasm

224324:AQ RS02785
gene id: 224324:AQ_RS02785
uniprot id: O66918
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

224324:AQ RS07620
gene id: 224324:AQ_RS07620
uniprot id: O67760
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex (By similarity).

224324:AQ RS08150
gene id: 224324:AQ_RS08150
uniprot id: O67857
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

224324:AQ RS00410
gene id: 224324:AQ_RS00410
uniprot id: O66505
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with SecDF, and other proteins may be involved. The channel interacts with SecA via subunit SecY.
messages: Subunit of the protein translocation channel SecYEG.

224324:AQ RS00095
gene id: 224324:AQ_RS00095
uniprot id: O66444
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS06325
gene id: 224324:AQ_RS06325
uniprot id: O67550
names: Function
messages: 5'-3' exonuclease acting preferentially on double-stranded DNA.

224324:AQ RS04510
gene id: 224324:AQ_RS04510
uniprot id: O67224
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

224324:AQ RS05075
gene id: 224324:AQ_RS05075
uniprot id: O67322
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency. Does not have kinase activity.
messages: Monomer.

224324:AQ RS05695
gene id: 224324:AQ_RS05695
uniprot id: O67436
names: Subcellular Location Annotation
messages: Periplasm

224324:AQ RS03850
gene id: 224324:AQ_RS03850
uniprot id: O67102
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

224324:AQ RS05555
gene id: 224324:AQ_RS05555
uniprot id: O67409
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

224324:AQ RS06940
gene id: 224324:AQ_RS06940
uniprot id: O67648
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

224324:AQ RS03805
gene id: 224324:AQ_RS03805
uniprot id: O67095
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

224324:AQ RS01910
gene id: 224324:AQ_RS01910
uniprot id: O66770
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

224324:AQ RS07905
gene id: 224324:AQ_RS07905
uniprot id: O67812
names: Similarity
messages: Belongs to the UPF0047 family.

224324:AQ RS02280
gene id: 224324:AQ_RS02280
uniprot id: O66833
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

224324:AQ RS08495
gene id: 224324:AQ_RS08495
uniprot id: O67917
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

224324:AQ RS03150
gene id: 224324:AQ_RS03150
uniprot id: O66987
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

224324:AQ RS01825
gene id: 224324:AQ_RS01825
uniprot id: O66755
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

224324:AQ RS03220
gene id: 224324:AQ_RS03220
uniprot id: O67001
names: Similarity
messages: To A.aeolicus aq_1211 and aq_1583.

224324:AQ RS00370
gene id: 224324:AQ_RS00370
uniprot id: O66496
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdsA family.
messages: Cytoplasm
messages: Oligomer.

224324:AQ RS03075
gene id: 224324:AQ_RS03075
uniprot id: O66974
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

224324:AQ RS04440
gene id: 224324:AQ_RS04440
uniprot id: O67211
names: Similarity
messages: Belongs to the LacAB/RpiB family.

224324:AQ RS07390
gene id: 224324:AQ_RS07390
uniprot id: O67725
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase.

224324:AQ RS06930
gene id: 224324:AQ_RS06930
uniprot id: O67646
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Seems to consist of an alpha chain and a beta chain.

224324:AQ RS05110
gene id: 224324:AQ_RS05110
uniprot id: O67329
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

224324:AQ RS05440
gene id: 224324:AQ_RS05440
uniprot id: O67390
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

224324:AQ RS06430
gene id: 224324:AQ_RS06430
uniprot id: O67568
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

224324:AQ RS05870
gene id: 224324:AQ_RS05870
uniprot id: O67466
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

224324:AQ RS05430
gene id: 224324:AQ_RS05430
uniprot id: O67388
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

224324:AQ RS02965
gene id: 224324:AQ_RS02965
uniprot id: O66953
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.

224324:AQ RS00740
gene id: 224324:AQ_RS00740
uniprot id: O66563
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

224324:AQ RS05145
gene id: 224324:AQ_RS05145
uniprot id: O67336
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

224324:AQ RS00155
gene id: 224324:AQ_RS00155
uniprot id: O66455
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

224324:AQ RS08680
gene id: 224324:AQ_RS08680
uniprot id: O66401
names: Similarity
messages: Belongs to the transposase 35 family.

224324:AQ RS00060
gene id: 224324:AQ_RS00060
uniprot id: P56613
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

224324:AQ RS06295
gene id: 224324:AQ_RS06295
uniprot id: O67546
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

224324:AQ RS07735
gene id: 224324:AQ_RS07735
uniprot id: O67781
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the reversible conversion of aspartate and 2-oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of aspartate.
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS08265
gene id: 224324:AQ_RS08265
uniprot id: O67877
names: Similarity
messages: Belongs to the histone deacetylase family.

224324:AQ RS03330
gene id: 224324:AQ_RS03330
uniprot id: O67016
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

224324:AQ RS08105
gene id: 224324:AQ_RS08105
uniprot id: O67849
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

224324:AQ RS06395
gene id: 224324:AQ_RS06395
uniprot id: O67561
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

224324:AQ RS02250
gene id: 224324:AQ_RS02250
uniprot id: O66827
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Has a putative N-terminal zinc-finger, a middle region with homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

224324:AQ RS08190
gene id: 224324:AQ_RS08190
uniprot id: O67863
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm

224324:AQ RS03495
gene id: 224324:AQ_RS03495
uniprot id: O67043
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

224324:AQ RS05140
gene id: 224324:AQ_RS05140
uniprot id: O67335
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.
messages: In the N-terminal section; belongs to the complex I 30 kDa subunit family.
messages: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex (By similarity).
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

224324:AQ RS07410
gene id: 224324:AQ_RS07410
uniprot id: O67728
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

224324:AQ RS04960
gene id: 224324:AQ_RS04960
uniprot id: O67304
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Cell membrane
messages: Involved in peptide utilization.

224324:AQ RS00165
gene id: 224324:AQ_RS00165
uniprot id: O66457
names: Similarity
messages: Belongs to the UPF0102 family.

224324:AQ RS04400
gene id: 224324:AQ_RS04400
uniprot id: O67203
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

224324:AQ RS03645
gene id: 224324:AQ_RS03645
uniprot id: O67069
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers (PubMed:12746447).
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

224324:AQ RS05090
gene id: 224324:AQ_RS05090
uniprot id: O67325
names: Similarity
messages: Belongs to the ClpA/ClpB family.

224324:AQ RS07930
gene id: 224324:AQ_RS07930
uniprot id: O67817
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

224324:AQ RS00870
gene id: 224324:AQ_RS00870
uniprot id: O66589
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

224324:AQ RS05100
gene id: 224324:AQ_RS05100
uniprot id: O67327
names: Subcellular Location Annotation
messages: Cytoplasm

224324:AQ RS06985
gene id: 224324:AQ_RS06985
uniprot id: O67655
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

224324:AQ RS07215
gene id: 224324:AQ_RS07215
uniprot id: O67696
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS04445
gene id: 224324:AQ_RS04445
uniprot id: O67212
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS05390
gene id: 224324:AQ_RS05390
uniprot id: O67379
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.
messages: Involved in biosynthesis of di-myo-inositol phosphate (DIP), a widespread organic solute in microorganisms adapted to hot environments. Catalyzes the condensation of CTP and L-myo-inositol-1-phosphate into CDP-L-myo-inositol, as well as the biosynthesis of di-myo-inositol-1,3'-phosphate-1'-phosphate (DIPP) from CDP-L-myo-inositol and L-myo-inositol-1-phosphate.
messages: Membrane

224324:AQ RS03390
gene id: 224324:AQ_RS03390
uniprot id: O67027
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS07710
gene id: 224324:AQ_RS07710
uniprot id: O67777
names: Similarity
messages: Belongs to the UPF0047 family.

224324:AQ RS03455
gene id: 224324:AQ_RS03455
uniprot id: O67036
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

224324:AQ RS05005
gene id: 224324:AQ_RS05005
uniprot id: O67310
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamD family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

224324:AQ RS04280
gene id: 224324:AQ_RS04280
uniprot id: O67182
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

224324:AQ RS08565
gene id: 224324:AQ_RS08565
uniprot id: O67929
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

224324:AQ RS07460
gene id: 224324:AQ_RS07460
uniprot id: O67738
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To A.aeolicus aq_1446.

224324:AQ RS00035
gene id: 224324:AQ_RS00035
uniprot id: O66434
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

224324:AQ RS03185
gene id: 224324:AQ_RS03185
uniprot id: O66994
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell membrane

224324:AQ RS03445
gene id: 224324:AQ_RS03445
uniprot id: O67034
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity).
messages: Interacts with MinD and FtsZ.

224324:AQ RS08225
gene id: 224324:AQ_RS08225
uniprot id: O67869
names: Caution
names: Cofactor
names: Domain
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: CarB is split into two genes in A.aeolicus (AQ_1172 and AQ_2101).
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Corresponds to the N-terminal section.

224324:AQ RS00520
gene id: 224324:AQ_RS00520
uniprot id: O66524
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A probable RNA-binding protein.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm

224324:AQ RS06515
gene id: 224324:AQ_RS06515
uniprot id: O67584
names: Similarity
messages: Belongs to the HepT RNase toxin family.

224324:AQ RS07040
gene id: 224324:AQ_RS07040
uniprot id: O67665
names: Similarity
messages: Belongs to the transglycosylase Slt family.

224324:AQ RS03205
gene id: 224324:AQ_RS03205
uniprot id: O66998
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS04125
gene id: 224324:AQ_RS04125
uniprot id: O67155
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

224324:AQ RS01160
gene id: 224324:AQ_RS01160
uniprot id: O66640
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Although the Valle et al., electron microscopy paper indicates this protein came from T.thermophilus its sequence maps to A.aeolicus.
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

224324:AQ RS03625
gene id: 224324:AQ_RS03625
uniprot id: O67065
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2Fe2S plant-type ferredoxin family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

224324:AQ RS05595
gene id: 224324:AQ_RS05595
uniprot id: O67417
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

224324:AQ RS01820
gene id: 224324:AQ_RS01820
uniprot id: O66754
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

224324:AQ RS05175
gene id: 224324:AQ_RS05175
uniprot id: O67342
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

224324:AQ RS00405
gene id: 224324:AQ_RS00405
uniprot id: O66504
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS07605
gene id: 224324:AQ_RS07605
uniprot id: O67757
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NusG family.
messages: Contains an N-terminal RNP-like domain, a C-terminal element with a KOW sequence motif and a species-specific immunoglobulin-like fold.
messages: Monomer (PubMed:12198166). Homodimer (PubMed:12600194).
messages: Participates in transcription elongation, termination and antitermination.

224324:AQ RS00940
gene id: 224324:AQ_RS00940
uniprot id: O66602
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

224324:AQ RS03285
gene id: 224324:AQ_RS03285
uniprot id: O67009
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

224324:AQ RS00340
gene id: 224324:AQ_RS00340
uniprot id: O66491
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA (By similarity).
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity).

224324:AQ RS05795
gene id: 224324:AQ_RS05795
uniprot id: O67452
names: Similarity
messages: Belongs to the GSP E family.

224324:AQ RS02780
gene id: 224324:AQ_RS02780
uniprot id: O66917
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

224324:AQ RS07760
gene id: 224324:AQ_RS07760
uniprot id: O67786
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Monomer.

224324:AQ RS07590
gene id: 224324:AQ_RS07590
uniprot id: O67756
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

224324:AQ RS03155
gene id: 224324:AQ_RS03155
uniprot id: O66988
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

224324:AQ RS00350
gene id: 224324:AQ_RS00350
uniprot id: O66493
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

224324:AQ RS03305
gene id: 224324:AQ_RS03305
uniprot id: O67013
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

224324:AQ RS08585
gene id: 224324:AQ_RS08585
uniprot id: O67933
names: Similarity
messages: Belongs to the SCO1/2 family.

224324:AQ RS00020
gene id: 224324:AQ_RS00020
uniprot id: O66431
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

224324:AQ RS02875
gene id: 224324:AQ_RS02875
uniprot id: O66936
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

224324:AQ RS06865
gene id: 224324:AQ_RS06865
uniprot id: O67638
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.

224324:AQ RS02765
gene id: 224324:AQ_RS02765
uniprot id: O66914
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

224324:AQ RS05950
gene id: 224324:AQ_RS05950
uniprot id: O67480
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

224324:AQ RS07815
gene id: 224324:AQ_RS07815
uniprot id: O67795
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

224324:AQ RS05045
gene id: 224324:AQ_RS05045
uniprot id: O67317
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

224324:AQ RS06540
gene id: 224324:AQ_RS06540
uniprot id: O67588
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent (By similarity).
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
messages: The Clp repeat (R) domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer (By similarity).

224324:AQ RS00300
gene id: 224324:AQ_RS00300
uniprot id: O66483
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

224324:AQ RS07115
gene id: 224324:AQ_RS07115
uniprot id: O67680
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

224324:AQ RS02670
gene id: 224324:AQ_RS02670
uniprot id: O66895
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

224324:AQ RS08690
gene id: 224324:AQ_RS08690
uniprot id: O66402
names: Similarity
messages: To A.aeolicus AA11 and AA34.

224324:AQ RS08445
gene id: 224324:AQ_RS08445
uniprot id: O67907
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

224324:AQ RS02535
gene id: 224324:AQ_RS02535
uniprot id: O66878
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible SMC hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

224324:AQ RS07305
gene id: 224324:AQ_RS07305
uniprot id: O67711
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

224324:AQ RS08935
gene id: 224324:AQ_RS08935
uniprot id: O66426
names: Function
names: Similarity
messages: Belongs to the fic family.
messages: Probable adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins.

224324:AQ RS08720
gene id: 224324:AQ_RS08720
uniprot id: O66404
names: Similarity
messages: To A.aeolicus AQ_423.

224324:AQ RS04070
gene id: 224324:AQ_RS04070
uniprot id: O67146
names: Subcellular Location Annotation
messages: Periplasm

224324:AQ RS06510
gene id: 224324:AQ_RS06510
uniprot id: O67583
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS01905
gene id: 224324:AQ_RS01905
uniprot id: O66769
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

224324:AQ RS00775
gene id: 224324:AQ_RS00775
uniprot id: O66570
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription (By similarity).

224324:AQ RS02865
gene id: 224324:AQ_RS02865
uniprot id: O66934
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

224324:AQ RS03290
gene id: 224324:AQ_RS03290
uniprot id: O67010
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates the guanine residues at position 26 and 27 of one or more tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

224324:AQ RS02645
gene id: 224324:AQ_RS02645
uniprot id: O66892
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

224324:AQ RS04870
gene id: 224324:AQ_RS04870
uniprot id: O67288
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

224324:AQ RS08145
gene id: 224324:AQ_RS08145
uniprot id: O67856
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS05535
gene id: 224324:AQ_RS05535
uniprot id: O67406
names: Function
names: Subcellular Location Annotation
messages: Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose.
messages: Cell inner membrane

224324:AQ RS06455
gene id: 224324:AQ_RS06455
uniprot id: O67573
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

224324:AQ RS05820
gene id: 224324:AQ_RS05820
uniprot id: O67456
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

224324:AQ RS06160
gene id: 224324:AQ_RS06160
uniprot id: O67522
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

224324:AQ RS08390
gene id: 224324:AQ_RS08390
uniprot id: O67898
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

224324:AQ RS06835
gene id: 224324:AQ_RS06835
uniprot id: O67632
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS04710
gene id: 224324:AQ_RS04710
uniprot id: O67260
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

224324:AQ RS00190
gene id: 224324:AQ_RS00190
uniprot id: O66462
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

224324:AQ RS01780
gene id: 224324:AQ_RS01780
uniprot id: O66746
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

224324:AQ RS02245
gene id: 224324:AQ_RS02245
uniprot id: O66826
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.
messages: In the N-terminal section; belongs to the complex I 30 kDa subunit family.
messages: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex (By similarity).
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

224324:AQ RS04595
gene id: 224324:AQ_RS04595
uniprot id: O67239
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

224324:AQ RS00495
gene id: 224324:AQ_RS00495
uniprot id: O66519
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

224324:AQ RS02360
gene id: 224324:AQ_RS02360
uniprot id: O66847
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).

224324:AQ RS02970
gene id: 224324:AQ_RS02970
uniprot id: O66954
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PGI/PMI family.
messages: Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.
messages: Homodimer.

224324:AQ RS08030
gene id: 224324:AQ_RS08030
uniprot id: O67836
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

224324:AQ RS00550
gene id: 224324:AQ_RS00550
uniprot id: O66530
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

224324:AQ RS00645
gene id: 224324:AQ_RS00645
uniprot id: O66545
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To R.prowazekii RP382.

224324:AQ RS00450
gene id: 224324:AQ_RS00450
uniprot id: O66512
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

224324:AQ RS07755
gene id: 224324:AQ_RS07755
uniprot id: O67785
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds 1 Fe(2+) cation per monomer.
messages: Binds 1 nickel ion per monomer.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Monomer.

224324:AQ RS02315
gene id: 224324:AQ_RS02315
uniprot id: O66839
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

224324:AQ RS04770
gene id: 224324:AQ_RS04770
uniprot id: O67271
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

224324:AQ RS04555
gene id: 224324:AQ_RS04555
uniprot id: O67232
names: Cofactor
names: Subunit
messages: Binds 2 [4Fe-4S] clusters.
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

224324:AQ RS05675
gene id: 224324:AQ_RS05675
uniprot id: O67432
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

224324:AQ RS01290
gene id: 224324:AQ_RS01290
uniprot id: O66663
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 30 subfamily.
messages: Can form homodimer, homotrimer and homotetramer.
messages: Cell inner membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of a single 3-deoxy-D-manno-octulosonate (Kdo) residue from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. Is strictly monofunctional, i.e. is capable of adding only a single Kdo residue to the acceptor lipid.

224324:AQ RS05645
gene id: 224324:AQ_RS05645
uniprot id: O67427
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS07250
gene id: 224324:AQ_RS07250
uniprot id: O67703
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Dimer of large and small chains.

224324:AQ RS08670
gene id: 224324:AQ_RS08670
uniprot id: O66399
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a type II toxin-antitoxin (TA) system. An RNase.

224324:AQ RS07290
gene id: 224324:AQ_RS07290
uniprot id: O67708
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

224324:AQ RS05340
gene id: 224324:AQ_RS05340
uniprot id: O67371
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

224324:AQ RS00335
gene id: 224324:AQ_RS00335
uniprot id: O66490
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

224324:AQ RS03165
gene id: 224324:AQ_RS03165
uniprot id: O66990
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 1 Zn(2+) ion per subunit (PubMed:15381710, PubMed:15826652, PubMed:19128030, PubMed:24314009). Fully functional with a mononuclear metal center. Does not require a second metal for activity, although the conservation of the second metal-binding site during evolution leaves open the possibility that a second ion might bind in vivo (PubMed:24314009).
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Monomer. Forms a 1:1 stoichiometric complex with PyrB. The complex exists as an equilibrium mixture of heterohexamers, composed of 3 PyrC and 3 PyrB subunits, and dodecamers. The complex has both DHOase and ATCase activities.
messages: The monomer has very low activity by itself. Activated several thousandfold by formation of a complex with PyrB aspartate carbamoyltransferase (ATCase).

224324:AQ RS08310
gene id: 224324:AQ_RS08310
uniprot id: O67884
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS07370
gene id: 224324:AQ_RS07370
uniprot id: O67721
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

224324:AQ RS07080
gene id: 224324:AQ_RS07080
uniprot id: O67673
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SoxA family.
messages: Binds 2 heme groups per subunit.
messages: Heterodimer of SoxA and SoxX.
messages: Periplasm

224324:AQ RS06720
gene id: 224324:AQ_RS06720
uniprot id: O67617
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

224324:AQ RS07530
gene id: 224324:AQ_RS07530
uniprot id: O67749
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

224324:AQ RS07850
gene id: 224324:AQ_RS07850
uniprot id: O67802
names: Similarity
messages: Belongs to the dienelactone hydrolase family.

224324:AQ RS00270
gene id: 224324:AQ_RS00270
uniprot id: O66478
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

224324:AQ RS04450
gene id: 224324:AQ_RS04450
uniprot id: O67213
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

224324:AQ RS01150
gene id: 224324:AQ_RS01150
uniprot id: O66638
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

224324:AQ RS06765
gene id: 224324:AQ_RS06765
uniprot id: O67623
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

224324:AQ RS07175
gene id: 224324:AQ_RS07175
uniprot id: O67690
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity).
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11 (By similarity).

224324:AQ RS03585
gene id: 224324:AQ_RS03585
uniprot id: O67058
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS02730
gene id: 224324:AQ_RS02730
uniprot id: O66907
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

224324:AQ RS02705
gene id: 224324:AQ_RS02705
uniprot id: O66902
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

224324:AQ RS00670
gene id: 224324:AQ_RS00670
uniprot id: O66550
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

224324:AQ RS02880
gene id: 224324:AQ_RS02880
uniprot id: O66937
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the disproportionating enzyme family.
messages: Cytoplasm

224324:AQ RS05180
gene id: 224324:AQ_RS05180
uniprot id: O67343
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

224324:AQ RS07990
gene id: 224324:AQ_RS07990
uniprot id: O67828
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

224324:AQ RS05925
gene id: 224324:AQ_RS05925
uniprot id: O67475
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
messages: Tetramer of two alpha and two beta subunits.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

224324:AQ RS00345
gene id: 224324:AQ_RS00345
uniprot id: O66492
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

224324:AQ RS00310
gene id: 224324:AQ_RS00310
uniprot id: O66485
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

224324:AQ RS01845
gene id: 224324:AQ_RS01845
uniprot id: O66759
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

224324:AQ RS02850
gene id: 224324:AQ_RS02850
uniprot id: O66931
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

224324:AQ RS03225
gene id: 224324:AQ_RS03225
uniprot id: O67002
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

224324:AQ RS01915
gene id: 224324:AQ_RS01915
uniprot id: O66771
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS07840
gene id: 224324:AQ_RS07840
uniprot id: O67800
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity). The GTPase is stimulated about 6-fold in the presence of a 12 nucleotide 16S rRNA C-terminal fragment. Mutations in the rRNA sequence obviate stimulation. RNA-binding depends on GTP-binding by the GTPase domain. May function as a checkpoint for assembly of the 30S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

224324:AQ RS06405
gene id: 224324:AQ_RS06405
uniprot id: O67563
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

224324:AQ RS08615
gene id: 224324:AQ_RS08615
uniprot id: O67939
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane

224324:AQ RS07225
gene id: 224324:AQ_RS07225
uniprot id: O67698
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

224324:AQ RS07610
gene id: 224324:AQ_RS07610
uniprot id: O67758
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

224324:AQ RS01785
gene id: 224324:AQ_RS01785
uniprot id: O66747
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.
messages: Homodimer.

224324:AQ RS06530
gene id: 224324:AQ_RS06530
uniprot id: O67587
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

224324:AQ RS08705
gene id: 224324:AQ_RS08705
uniprot id: O66403
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: May function as an integrase.

224324:AQ RS05995
gene id: 224324:AQ_RS05995
uniprot id: O67489
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Membrane

224324:AQ RS03125
gene id: 224324:AQ_RS03125
uniprot id: O66983
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

224324:AQ RS00245
gene id: 224324:AQ_RS00245
uniprot id: O66473
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cytoplasm
messages: Homodimer or homotetramer.

224324:AQ RS03845
gene id: 224324:AQ_RS03845
uniprot id: O67101
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

224324:AQ RS07110
gene id: 224324:AQ_RS07110
uniprot id: O67679
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

224324:AQ RS03065
gene id: 224324:AQ_RS03065
uniprot id: O66972
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

224324:AQ RS02460
gene id: 224324:AQ_RS02460
uniprot id: O66864
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

224324:AQ RS01670
gene id: 224324:AQ_RS01670
uniprot id: O66727
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

224324:AQ RS06155
gene id: 224324:AQ_RS06155
uniprot id: O67521
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS04790
gene id: 224324:AQ_RS04790
uniprot id: O67274
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm

224324:AQ RS04350
gene id: 224324:AQ_RS04350
uniprot id: O67193
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

224324:AQ RS00830
gene id: 224324:AQ_RS00830
uniprot id: O66581
names: Function
names: Similarity
messages: Belongs to the ATPase gamma chain family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

224324:AQ RS04795
gene id: 224324:AQ_RS04795
uniprot id: O67275
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

224324:AQ RS03830
gene id: 224324:AQ_RS03830
uniprot id: O67098
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

224324:AQ RS03655
gene id: 224324:AQ_RS03655
uniprot id: O67071
names: Similarity
messages: Belongs to the flavoredoxin family.

224324:AQ RS07615
gene id: 224324:AQ_RS07615
uniprot id: O67759
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

224324:AQ RS07295
gene id: 224324:AQ_RS07295
uniprot id: O67709
names: Similarity
messages: Belongs to the HesB/IscA family.

224324:AQ RS03945
gene id: 224324:AQ_RS03945
uniprot id: O67121
names: Similarity
messages: Belongs to the MotB family.

224324:AQ RS05940
gene id: 224324:AQ_RS05940
uniprot id: O67478
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

224324:AQ RS01840
gene id: 224324:AQ_RS01840
uniprot id: O66758
names: Similarity
messages: Belongs to the UPF0166 family.

224324:AQ RS05130
gene id: 224324:AQ_RS05130
uniprot id: O67333
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

224324:AQ RS03300
gene id: 224324:AQ_RS03300
uniprot id: O67012
names: Function
names: Similarity
messages: Belongs to the RelA/SpoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp (By similarity).

224324:AQ RS02855
gene id: 224324:AQ_RS02855
uniprot id: O66932
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity).

224324:AQ RS04600
gene id: 224324:AQ_RS04600
uniprot id: O67240
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

224324:AQ RS04085
gene id: 224324:AQ_RS04085
uniprot id: O67149
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

224324:AQ RS00025
gene id: 224324:AQ_RS00025
uniprot id: O66432
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

224324:AQ RS06265
gene id: 224324:AQ_RS06265
uniprot id: O67540
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

224324:AQ RS01775
gene id: 224324:AQ_RS01775
uniprot id: O66745
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

224324:AQ RS07690
gene id: 224324:AQ_RS07690
uniprot id: O67773
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Role in flagellar biosynthesis.

224324:AQ RS04970
gene id: 224324:AQ_RS04970
uniprot id: O67305
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

224324:AQ RS00750
gene id: 224324:AQ_RS00750
uniprot id: O66565
names: Similarity
messages: Belongs to the universal stress protein A family.

224324:AQ RS03595
gene id: 224324:AQ_RS03595
uniprot id: O67060
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

224324:AQ RS02835
gene id: 224324:AQ_RS02835
uniprot id: O66928
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

224324:AQ RS04005
gene id: 224324:AQ_RS04005
uniprot id: O67132
names: Similarity
messages: Belongs to the HypE family.

224324:AQ RS05610
gene id: 224324:AQ_RS05610
uniprot id: O67420
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

224324:AQ RS07310
gene id: 224324:AQ_RS07310
uniprot id: O67712
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.

224324:AQ RS05375
gene id: 224324:AQ_RS05375
uniprot id: O67377
names: Cofactor
names: Function
names: Similarity
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity).
messages: Binds 1 potassium ion per subunit.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

224324:AQ RS07100
gene id: 224324:AQ_RS07100
uniprot id: O67677
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

224324:AQ RS06030
gene id: 224324:AQ_RS06030
uniprot id: O67496
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
messages: Homodimer.

224324:AQ RS03350
gene id: 224324:AQ_RS03350
uniprot id: O67020
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

224324:AQ RS03270
gene id: 224324:AQ_RS03270
uniprot id: O67006
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

224324:AQ RS05510
gene id: 224324:AQ_RS05510
uniprot id: O67401
names: Similarity
messages: Belongs to the glycosyl hydrolase 8 (cellulase D) family.

224324:AQ RS06425
gene id: 224324:AQ_RS06425
uniprot id: P0A4B1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

224324:AQ RS08305
gene id: 224324:AQ_RS08305
uniprot id: O67883
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Homodimer.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

224324:AQ RS05780
gene id: 224324:AQ_RS05780
uniprot id: O67450
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

224324:AQ RS03345
gene id: 224324:AQ_RS03345
uniprot id: O67019
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

224324:AQ RS05600
gene id: 224324:AQ_RS05600
uniprot id: O67418
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

224324:AQ RS03755
gene id: 224324:AQ_RS03755
uniprot id: O67085
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

224324:AQ RS00825
gene id: 224324:AQ_RS00825
uniprot id: O66580
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

224324:AQ RS06050
gene id: 224324:AQ_RS06050
uniprot id: O67500
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

224324:AQ RS02640
gene id: 224324:AQ_RS02640
uniprot id: O66891
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of 2 proteins (FliG, FliN) that might form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).

224324:AQ RS02760
gene id: 224324:AQ_RS02760
uniprot id: O66913
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

224324:AQ RS08450
gene id: 224324:AQ_RS08450
uniprot id: O67908
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Cell membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

224324:AQ RS01175
gene id: 224324:AQ_RS01175
uniprot id: O66643
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS01835
gene id: 224324:AQ_RS01835
uniprot id: O66757
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

224324:AQ RS04800
gene id: 224324:AQ_RS04800
uniprot id: O67276
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS03705
gene id: 224324:AQ_RS03705
uniprot id: O67078
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

224324:AQ RS04425
gene id: 224324:AQ_RS04425
uniprot id: O67208
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

224324:AQ RS06475
gene id: 224324:AQ_RS06475
uniprot id: O67577
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA. Type II methylase, which methylates only a subset of tRNA species.
messages: Homodimer.

224324:AQ RS01010
gene id: 224324:AQ_RS01010
uniprot id: O66615
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

224324:AQ RS08325
gene id: 224324:AQ_RS08325
uniprot id: O67887
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

224324:AQ RS07350
gene id: 224324:AQ_RS07350
uniprot id: O67718
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

224324:AQ RS05580
gene id: 224324:AQ_RS05580
uniprot id: O67414
names: Similarity
messages: Belongs to the transglycosylase Slt family.

224324:AQ RS02920
gene id: 224324:AQ_RS02920
uniprot id: O70089
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

224324:AQ RS05470
gene id: 224324:AQ_RS05470
uniprot id: O67395
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

224324:AQ RS08005
gene id: 224324:AQ_RS08005
uniprot id: O67831
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS05305
gene id: 224324:AQ_RS05305
uniprot id: O67364
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Cell membrane

224324:AQ RS00855
gene id: 224324:AQ_RS00855
uniprot id: O66586
names: Similarity
messages: Belongs to the globin family.

224324:AQ RS08530
gene id: 224324:AQ_RS08530
uniprot id: O67923
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

224324:AQ RS06390
gene id: 224324:AQ_RS06390
uniprot id: O67560
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

224324:AQ RS02155
gene id: 224324:AQ_RS02155
uniprot id: O66811
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.

224324:AQ RS07770
gene id: 224324:AQ_RS07770
uniprot id: O67788
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).

224324:AQ RS03070
gene id: 224324:AQ_RS03070
uniprot id: O66973
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
messages: Cytoplasm

224324:AQ RS01170
gene id: 224324:AQ_RS01170
uniprot id: O66642
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

224324:AQ RS02490
gene id: 224324:AQ_RS02490
uniprot id: O66869
names: Similarity
messages: Belongs to the peptidase C56 family.

224324:AQ RS05195
gene id: 224324:AQ_RS05195
uniprot id: O67346
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS03135
gene id: 224324:AQ_RS03135
uniprot id: O66985
names: Similarity
messages: Belongs to the peptidase S41A family.

224324:AQ RS05420
gene id: 224324:AQ_RS05420
uniprot id: O67386
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

224324:AQ RS02800
gene id: 224324:AQ_RS02800
uniprot id: O66921
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

224324:AQ RS05070
gene id: 224324:AQ_RS05070
uniprot id: O67321
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

224324:AQ RS07910
gene id: 224324:AQ_RS07910
uniprot id: O67813
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell inner membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin (By similarity).

224324:AQ RS02805
gene id: 224324:AQ_RS02805
uniprot id: O66922
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

224324:AQ RS07160
gene id: 224324:AQ_RS07160
uniprot id: O67688
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To P.aeruginosa PA0043 and M.thermoautotrophicum MTH1451.

224324:AQ RS00690
gene id: 224324:AQ_RS00690
uniprot id: O66554
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.
messages: Homodimer.
messages: Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine. Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate. Also has adenosine deaminase activity.

224324:AQ RS06705
gene id: 224324:AQ_RS06705
uniprot id: O67614
names: Function
names: Similarity
names: Subunit
messages: Belongs to the hemerythrin family.
messages: Monomer.
messages: Oxygen-binding protein. May be involved in a storage mechanism or for delivery to oxygen-requiring enzymes. The oxygen-binding site contains two iron atoms.

224324:AQ RS01440
gene id: 224324:AQ_RS01440
uniprot id: O66685
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS07950
gene id: 224324:AQ_RS07950
uniprot id: O67820
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

224324:AQ RS03215
gene id: 224324:AQ_RS03215
uniprot id: O67000
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane

224324:AQ RS03840
gene id: 224324:AQ_RS03840
uniprot id: O67100
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

224324:AQ RS01240
gene id: 224324:AQ_RS01240
uniprot id: O66654
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

224324:AQ RS01410
gene id: 224324:AQ_RS01410
uniprot id: O66679
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

224324:AQ RS08745
gene id: 224324:AQ_RS08745
uniprot id: O66407
names: Similarity
messages: To M.jannaschii MJ0123 and MJ1213.

224324:AQ RS03005
gene id: 224324:AQ_RS03005
uniprot id: O66961
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Molecular chaperone capable of stabilizing a range of proteins.

224324:AQ RS03905
gene id: 224324:AQ_RS03905
uniprot id: O67113
names: Similarity
messages: Belongs to the SCO1/2 family.

224324:AQ RS03775
gene id: 224324:AQ_RS03775
uniprot id: O67089
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

224324:AQ RS04260
gene id: 224324:AQ_RS04260
uniprot id: O67178
names: Similarity
messages: In the C-terminal section; belongs to the protein sulfotransferase family.

224324:AQ RS00295
gene id: 224324:AQ_RS00295
uniprot id: O66482
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

224324:AQ RS03120
gene id: 224324:AQ_RS03120
uniprot id: O66982
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

224324:AQ RS02480
gene id: 224324:AQ_RS02480
uniprot id: O66867
names: Subcellular Location Annotation
messages: Cell membrane

224324:AQ RS06140
gene id: 224324:AQ_RS06140
uniprot id: O67518
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity).

224324:AQ RS00755
gene id: 224324:AQ_RS00755
uniprot id: O66566
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.

224324:AQ RS02525
gene id: 224324:AQ_RS02525
uniprot id: O66876
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

224324:AQ RS01185
gene id: 224324:AQ_RS01185
uniprot id: O66645
names: Subcellular Location Annotation
messages: Membrane

224324:AQ RS00130
gene id: 224324:AQ_RS00130
uniprot id: O66450
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

224324:AQ RS02590
gene id: 224324:AQ_RS02590
uniprot id: O66884
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
messages: Cytoplasm

224324:AQ RS02115
gene id: 224324:AQ_RS02115
uniprot id: O66803
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

224324:AQ RS08035
gene id: 224324:AQ_RS08035
uniprot id: O67837
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) (By similarity).

224324:AQ RS02425
gene id: 224324:AQ_RS02425
uniprot id: O66858
names: Similarity
messages: Belongs to the sigma-54 factor family.

224324:AQ RS02140
gene id: 224324:AQ_RS02140
uniprot id: O66808
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

224324:AQ RS01025
gene id: 224324:AQ_RS01025
uniprot id: O66617
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

224324:AQ RS04885
gene id: 224324:AQ_RS04885
uniprot id: O67291
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

224324:AQ RS07900
gene id: 224324:AQ_RS07900
uniprot id: O67811
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

224324:AQ RS01425
gene id: 224324:AQ_RS01425
uniprot id: O66682
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.

224324:AQ RS03430
gene id: 224324:AQ_RS03430
uniprot id: O67032
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1 (By similarity).
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

224324:AQ RS00400
gene id: 224324:AQ_RS00400
uniprot id: O66503
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
messages: Tetramer of two alpha and two beta subunits.
messages: Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding to separate specificity and activation sites on the alpha subunit. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction. Stimulated by ATP and inhibited by dATP binding to the activity site (By similarity).

224324:AQ RS03465
gene id: 224324:AQ_RS03465
uniprot id: O67037
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Binds two Mg(2+) per subunit.
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

224324:AQ RS03790
gene id: 224324:AQ_RS03790
uniprot id: O67092
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

224324:AQ RS05150
gene id: 224324:AQ_RS05150
uniprot id: O67337
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

224324:AQ RS02710
gene id: 224324:AQ_RS02710
uniprot id: O66903
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

224324:AQ RS06060
gene id: 224324:AQ_RS06060
uniprot id: O67502
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

224324:AQ RS01645
gene id: 224324:AQ_RS01645
uniprot id: O66722
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

224324:AQ RS08440
gene id: 224324:AQ_RS08440
uniprot id: O67906
names: Similarity
messages: Belongs to the GSP E family.

224324:AQ RS01235
gene id: 224324:AQ_RS01235
uniprot id: O66653
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

224324:AQ RS08760
gene id: 224324:AQ_RS08760
uniprot id: O66409
names: Similarity
messages: Belongs to the peptidase S8 family.

224324:AQ RS06415
gene id: 224324:AQ_RS06415
uniprot id: O67565
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

224324:AQ RS03485
gene id: 224324:AQ_RS03485
uniprot id: O67041
names: Similarity
messages: Belongs to the fabD family.

224324:AQ RS05485
gene id: 224324:AQ_RS05485
uniprot id: O67397
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

224324:AQ RS02380
gene id: 224324:AQ_RS02380
uniprot id: O66850
names: Similarity
messages: Belongs to the bacterial secretin family.

224324:AQ RS01465
gene id: 224324:AQ_RS01465
uniprot id: O66689
names: Similarity
messages: Belongs to the RutC family.

224324:AQ RS03010
gene id: 224324:AQ_RS03010
uniprot id: O66962
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits (By similarity).
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

224324:AQ RS07660
gene id: 224324:AQ_RS07660
uniprot id: O67768
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

224324:AQ RS07635
gene id: 224324:AQ_RS07635
uniprot id: O67763
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

224324:AQ RS07705
gene id: 224324:AQ_RS07705
uniprot id: O67776
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell inner membrane

224324:AQ RS01750
gene id: 224324:AQ_RS01750
uniprot id: O66742
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS02860
gene id: 224324:AQ_RS02860
uniprot id: O66933
names: Similarity
messages: Belongs to the phosphohexose mutase family.

224324:AQ RS07195
gene id: 224324:AQ_RS07195
uniprot id: O67693
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS02575
gene id: 224324:AQ_RS02575
uniprot id: O66882
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

224324:AQ RS07925
gene id: 224324:AQ_RS07925
uniprot id: O67816
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

224324:AQ RS01965
gene id: 224324:AQ_RS01965
uniprot id: O66778
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

224324:AQ RS02950
gene id: 224324:AQ_RS02950
uniprot id: O66950
names: Similarity
messages: Belongs to the GSP E family.

224324:AQ RS00325
gene id: 224324:AQ_RS00325
uniprot id: O66488
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

224324:AQ RS06135
gene id: 224324:AQ_RS06135
uniprot id: O67517
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

224324:AQ RS04515
gene id: 224324:AQ_RS04515
uniprot id: O67225
names: Similarity
messages: Belongs to the HypD family.

224324:AQ RS07870
gene id: 224324:AQ_RS07870
uniprot id: O67806
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

224324:AQ RS04310
gene id: 224324:AQ_RS04310
uniprot id: O67186
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

224324:AQ RS01950
gene id: 224324:AQ_RS01950
uniprot id: O66776
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

224324:AQ RS05585
gene id: 224324:AQ_RS05585
uniprot id: O67415
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

224324:AQ RS08260
gene id: 224324:AQ_RS08260
uniprot id: O67876
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Binds 1 zinc ion per monomer.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
messages: Homooctamer.

224324:AQ RS04655
gene id: 224324:AQ_RS04655
uniprot id: O67251
names: Cofactor
names: Subunit
messages: Binds 2 [4Fe-4S] clusters.
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.