2174846:DDW44 RS07695
gene id: 2174846:DDW44_RS07695
uniprot id: A0A2S1SQM3
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS17495
gene id: 2174846:DDW44_RS17495
uniprot id: A0A2S1SVE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2174846:DDW44 RS22710
gene id: 2174846:DDW44_RS22710
uniprot id: A0A2S1SY22
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS10215
gene id: 2174846:DDW44_RS10215
uniprot id: A0A2S1SS49
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS11740
gene id: 2174846:DDW44_RS11740
uniprot id: A0A2S1SSV2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS08310
gene id: 2174846:DDW44_RS08310
uniprot id: A0A2S1SQW6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

2174846:DDW44 RS15800
gene id: 2174846:DDW44_RS15800
uniprot id: A0A2S1SUJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

2174846:DDW44 RS22395
gene id: 2174846:DDW44_RS22395
uniprot id: A0A2S1SXW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

2174846:DDW44 RS26755
gene id: 2174846:DDW44_RS26755
uniprot id: A0A2S1T000
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS03875
gene id: 2174846:DDW44_RS03875
uniprot id: A0A2S1SNR0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

2174846:DDW44 RS04005
gene id: 2174846:DDW44_RS04005
uniprot id: A0A2S1SNT0
names: Similarity
messages: Belongs to the peptidase C40 family.

2174846:DDW44 RS08360
gene id: 2174846:DDW44_RS08360
uniprot id: A0A2S1SQX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

2174846:DDW44 RS07545
gene id: 2174846:DDW44_RS07545
uniprot id: A0A2S1SQH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

2174846:DDW44 RS06075
gene id: 2174846:DDW44_RS06075
uniprot id: A0A2S1SPT3
names: Similarity
messages: Belongs to the CdaR family.

2174846:DDW44 RS14160
gene id: 2174846:DDW44_RS14160
uniprot id: A0A2S1STS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

2174846:DDW44 RS22950
gene id: 2174846:DDW44_RS22950
uniprot id: A0A2S1SY55
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

2174846:DDW44 RS04050
gene id: 2174846:DDW44_RS04050
uniprot id: A0A2S1SNU3
names: Caution
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 heme c groups covalently per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.

2174846:DDW44 RS11225
gene id: 2174846:DDW44_RS11225
uniprot id: A0A2S1SSA5
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

2174846:DDW44 RS03645
gene id: 2174846:DDW44_RS03645
uniprot id: A0A2S1SNN2
names: Similarity
messages: Belongs to the YggT family.

2174846:DDW44 RS14805
gene id: 2174846:DDW44_RS14805
uniprot id: A0A2S1SU06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

2174846:DDW44 RS21290
gene id: 2174846:DDW44_RS21290
uniprot id: A0A2S1SXA0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS11495
gene id: 2174846:DDW44_RS11495
uniprot id: A0A2S1SSF6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

2174846:DDW44 RS16390
gene id: 2174846:DDW44_RS16390
uniprot id: A0A2S1SUU3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

2174846:DDW44 RS24390
gene id: 2174846:DDW44_RS24390
uniprot id: A0A2S1SYT0
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

2174846:DDW44 RS11230
gene id: 2174846:DDW44_RS11230
uniprot id: A0A2S1SSB3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

2174846:DDW44 RS04270
gene id: 2174846:DDW44_RS04270
uniprot id: A0A2S1SNX3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

2174846:DDW44 RS08800
gene id: 2174846:DDW44_RS08800
uniprot id: A0A2S1SR44
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

2174846:DDW44 RS09770
gene id: 2174846:DDW44_RS09770
uniprot id: A0A2S1SRK9
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

2174846:DDW44 RS17165
gene id: 2174846:DDW44_RS17165
uniprot id: A0A2S1SVA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

2174846:DDW44 RS19020
gene id: 2174846:DDW44_RS19020
uniprot id: A0A2S1SW55
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

2174846:DDW44 RS00640
gene id: 2174846:DDW44_RS00640
uniprot id: A0A2S1SM07
names: Similarity
messages: Belongs to the CsoR family.

2174846:DDW44 RS03060
gene id: 2174846:DDW44_RS03060
uniprot id: A0A2S1SND3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine-5'-phosphate glycosidase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
messages: Homotrimer.

2174846:DDW44 RS17355
gene id: 2174846:DDW44_RS17355
uniprot id: A0A2S1SVB2
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS08255
gene id: 2174846:DDW44_RS08255
uniprot id: A0A2S1SQV9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

2174846:DDW44 RS16655
gene id: 2174846:DDW44_RS16655
uniprot id: A0A2S1T361
names: Similarity
messages: Belongs to the DNA polymerase type-A family.

2174846:DDW44 RS15045
gene id: 2174846:DDW44_RS15045
uniprot id: A0A2S1SU69
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

2174846:DDW44 RS17155
gene id: 2174846:DDW44_RS17155
uniprot id: A0A2S1SV89
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

2174846:DDW44 RS12100
gene id: 2174846:DDW44_RS12100
uniprot id: A0A2S1SSV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. Tam family.
messages: Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
messages: Cytoplasm

2174846:DDW44 RS25765
gene id: 2174846:DDW44_RS25765
uniprot id: A0A2S1SZH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: Homotetramer.

2174846:DDW44 RS08000
gene id: 2174846:DDW44_RS08000
uniprot id: A0A2S1SQS6
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS17990
gene id: 2174846:DDW44_RS17990
uniprot id: A0A2S1SVN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

2174846:DDW44 RS09535
gene id: 2174846:DDW44_RS09535
uniprot id: A0A2S1SRH6
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS22705
gene id: 2174846:DDW44_RS22705
uniprot id: A0A2S1SXZ9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

2174846:DDW44 RS07470
gene id: 2174846:DDW44_RS07470
uniprot id: A0A2S1SQI0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

2174846:DDW44 RS09520
gene id: 2174846:DDW44_RS09520
uniprot id: A0A2S1SRH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

2174846:DDW44 RS24745
gene id: 2174846:DDW44_RS24745
uniprot id: A0A2S1SYY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2174846:DDW44 RS30100
gene id: 2174846:DDW44_RS30100
uniprot id: A0A2S1T1T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2174846:DDW44 RS27625
gene id: 2174846:DDW44_RS27625
uniprot id: A0A2S1T0K6
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS25675
gene id: 2174846:DDW44_RS25675
uniprot id: A0A2S1SZG9
names: Similarity
messages: Belongs to the hyi family.

2174846:DDW44 RS17470
gene id: 2174846:DDW44_RS17470
uniprot id: A0A2S1SVD8
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.

2174846:DDW44 RS16845
gene id: 2174846:DDW44_RS16845
uniprot id: A0A2S1SV17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2174846:DDW44 RS12325
gene id: 2174846:DDW44_RS12325
uniprot id: A0A2S1SSY1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

2174846:DDW44 RS19815
gene id: 2174846:DDW44_RS19815
uniprot id: A0A2S1SWJ7
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

2174846:DDW44 RS21485
gene id: 2174846:DDW44_RS21485
uniprot id: A0A2S1SXD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS02955
gene id: 2174846:DDW44_RS02955
uniprot id: A0A2S1SNB3
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

2174846:DDW44 RS23620
gene id: 2174846:DDW44_RS23620
uniprot id: A0A2S1SYF1
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

2174846:DDW44 RS08635
gene id: 2174846:DDW44_RS08635
uniprot id: A0A2S1SR65
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

2174846:DDW44 RS18115
gene id: 2174846:DDW44_RS18115
uniprot id: A0A2S1SW23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

2174846:DDW44 RS23070
gene id: 2174846:DDW44_RS23070
uniprot id: A0A2S1SY69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

2174846:DDW44 RS17370
gene id: 2174846:DDW44_RS17370
uniprot id: A0A2S1SVN6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

2174846:DDW44 RS06975
gene id: 2174846:DDW44_RS06975
uniprot id: A0A2S1SQ71
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

2174846:DDW44 RS31170
gene id: 2174846:DDW44_RS31170
uniprot id: A0A2S1T2G8
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

2174846:DDW44 RS07330
gene id: 2174846:DDW44_RS07330
uniprot id: A0A2S1SQD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

2174846:DDW44 RS22955
gene id: 2174846:DDW44_RS22955
uniprot id: A0A2S1SY52
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

2174846:DDW44 RS07870
gene id: 2174846:DDW44_RS07870
uniprot id: A0A2S1SQN7
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

2174846:DDW44 RS11375
gene id: 2174846:DDW44_RS11375
uniprot id: A0A2S1SSG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

2174846:DDW44 RS00970
gene id: 2174846:DDW44_RS00970
uniprot id: A0A2S1SM95
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

2174846:DDW44 RS15530
gene id: 2174846:DDW44_RS15530
uniprot id: A0A2S1SUQ8
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS16825
gene id: 2174846:DDW44_RS16825
uniprot id: A0A2S1SV18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2174846:DDW44 RS12755
gene id: 2174846:DDW44_RS12755
uniprot id: A0A2S1ST16
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

2174846:DDW44 RS16995
gene id: 2174846:DDW44_RS16995
uniprot id: A0A2S1SV58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DisA family.
messages: Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
messages: Homooctamer.
messages: Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation.

2174846:DDW44 RS13315
gene id: 2174846:DDW44_RS13315
uniprot id: A0A2S1T304
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

2174846:DDW44 RS02710
gene id: 2174846:DDW44_RS02710
uniprot id: A0A2S1SN50
names: Function
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.

2174846:DDW44 RS13400
gene id: 2174846:DDW44_RS13400
uniprot id: A0A2S1STE9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

2174846:DDW44 RS11510
gene id: 2174846:DDW44_RS11510
uniprot id: A0A2S1SSI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

2174846:DDW44 RS24765
gene id: 2174846:DDW44_RS24765
uniprot id: A0A2S1SYX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PAPS reductase family. CysD subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

2174846:DDW44 RS08940
gene id: 2174846:DDW44_RS08940
uniprot id: A0A2S1SR83
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

2174846:DDW44 RS03355
gene id: 2174846:DDW44_RS03355
uniprot id: A0A2S1SNH8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

2174846:DDW44 RS21445
gene id: 2174846:DDW44_RS21445
uniprot id: A0A2S1SXE3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS18535
gene id: 2174846:DDW44_RS18535
uniprot id: A0A2S1SVW4
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

2174846:DDW44 RS01095
gene id: 2174846:DDW44_RS01095
uniprot id: A0A2S1SM89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS09025
gene id: 2174846:DDW44_RS09025
uniprot id: A0A2S1SR82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

2174846:DDW44 RS27805
gene id: 2174846:DDW44_RS27805
uniprot id: A0A2S1T0N4
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.

2174846:DDW44 RS18130
gene id: 2174846:DDW44_RS18130
uniprot id: A0A2S1SVR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

2174846:DDW44 RS30095
gene id: 2174846:DDW44_RS30095
uniprot id: A0A2S1T1Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2174846:DDW44 RS22155
gene id: 2174846:DDW44_RS22155
uniprot id: A0A2S1SXM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS31080
gene id: 2174846:DDW44_RS31080
uniprot id: A0A2S1T2A2
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS28985
gene id: 2174846:DDW44_RS28985
uniprot id: A0A2S1T145
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS23175
gene id: 2174846:DDW44_RS23175
uniprot id: A0A2S1SY96
names: Subcellular Location Annotation
messages: Cell membrane

2174846:DDW44 RS02060
gene id: 2174846:DDW44_RS02060
uniprot id: A0A2S1SMS9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

2174846:DDW44 RS22170
gene id: 2174846:DDW44_RS22170
uniprot id: A0A2S1SY76
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

2174846:DDW44 RS02970
gene id: 2174846:DDW44_RS02970
uniprot id: A0A2S1T2Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

2174846:DDW44 RS19600
gene id: 2174846:DDW44_RS19600
uniprot id: A0A2S1SWT7
names: Similarity
messages: Belongs to the catalase family.

2174846:DDW44 RS21525
gene id: 2174846:DDW44_RS21525
uniprot id: A0A2S1T3E0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

2174846:DDW44 RS11405
gene id: 2174846:DDW44_RS11405
uniprot id: A0A2S1SSG7
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

2174846:DDW44 RS24415
gene id: 2174846:DDW44_RS24415
uniprot id: A0A2S1SZ95
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS07600
gene id: 2174846:DDW44_RS07600
uniprot id: A0A2S1SQI6
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS03205
gene id: 2174846:DDW44_RS03205
uniprot id: A0A2S1SNC0
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS15230
gene id: 2174846:DDW44_RS15230
uniprot id: A0A2S1SU97
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

2174846:DDW44 RS18210
gene id: 2174846:DDW44_RS18210
uniprot id: A0A2S1SVS2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

2174846:DDW44 RS09665
gene id: 2174846:DDW44_RS09665
uniprot id: A0A2S1SRJ7
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

2174846:DDW44 RS12060
gene id: 2174846:DDW44_RS12060
uniprot id: A0A2S1SST1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

2174846:DDW44 RS20025
gene id: 2174846:DDW44_RS20025
uniprot id: A0A2S1SWN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

2174846:DDW44 RS18105
gene id: 2174846:DDW44_RS18105
uniprot id: A0A2S1SVQ3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

2174846:DDW44 RS04360
gene id: 2174846:DDW44_RS04360
uniprot id: A0A2S1SNY6
names: Similarity
messages: Belongs to the glutamine synthetase family.

2174846:DDW44 RS13505
gene id: 2174846:DDW44_RS13505
uniprot id: A0A2S1STG7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS20625
gene id: 2174846:DDW44_RS20625
uniprot id: A0A2S1SWY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2174846:DDW44 RS04295
gene id: 2174846:DDW44_RS04295
uniprot id: A0A2S1SP10
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

2174846:DDW44 RS20955
gene id: 2174846:DDW44_RS20955
uniprot id: A0A2S1SX35
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

2174846:DDW44 RS02790
gene id: 2174846:DDW44_RS02790
uniprot id: A0A2S1SN41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.

2174846:DDW44 RS13415
gene id: 2174846:DDW44_RS13415
uniprot id: A0A2S1STF6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.

2174846:DDW44 RS11440
gene id: 2174846:DDW44_RS11440
uniprot id: A0A2S1SSE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

2174846:DDW44 RS06460
gene id: 2174846:DDW44_RS06460
uniprot id: A0A2S1SQ53
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

2174846:DDW44 RS21905
gene id: 2174846:DDW44_RS21905
uniprot id: A0A2S1SXL8
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

2174846:DDW44 RS17500
gene id: 2174846:DDW44_RS17500
uniprot id: A0A2S1SVE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2174846:DDW44 RS20390
gene id: 2174846:DDW44_RS20390
uniprot id: A0A2S1SWT9
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

2174846:DDW44 RS18035
gene id: 2174846:DDW44_RS18035
uniprot id: A0A2S1SVN4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

2174846:DDW44 RS20035
gene id: 2174846:DDW44_RS20035
uniprot id: A0A2S1T378
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

2174846:DDW44 RS19645
gene id: 2174846:DDW44_RS19645
uniprot id: A0A2S1SWG9
names: Similarity
messages: Belongs to the nitroreductase family. HadB/RutE subfamily.

2174846:DDW44 RS04960
gene id: 2174846:DDW44_RS04960
uniprot id: A0A2S1SP88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS11320
gene id: 2174846:DDW44_RS11320
uniprot id: A0A2S1SSE4
names: Similarity
messages: Belongs to the barstar family.

2174846:DDW44 RS06060
gene id: 2174846:DDW44_RS06060
uniprot id: A0A2S1SPT7
names: Subcellular Location Annotation
messages: Cytoplasm

2174846:DDW44 RS17965
gene id: 2174846:DDW44_RS17965
uniprot id: A0A2S1SVM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

2174846:DDW44 RS23660
gene id: 2174846:DDW44_RS23660
uniprot id: A0A2S1SYD6
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS08060
gene id: 2174846:DDW44_RS08060
uniprot id: A0A2S1SQR6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

2174846:DDW44 RS22760
gene id: 2174846:DDW44_RS22760
uniprot id: A0A2S1SY09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

2174846:DDW44 RS07375
gene id: 2174846:DDW44_RS07375
uniprot id: A0A2S1SQH2
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

2174846:DDW44 RS05135
gene id: 2174846:DDW44_RS05135
uniprot id: A0A2S1SPE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

2174846:DDW44 RS06595
gene id: 2174846:DDW44_RS06595
uniprot id: A0A2S1SQ15
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

2174846:DDW44 RS08355
gene id: 2174846:DDW44_RS08355
uniprot id: A0A2S1SQX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

2174846:DDW44 RS18000
gene id: 2174846:DDW44_RS18000
uniprot id: A0A2S1SVP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

2174846:DDW44 RS26325
gene id: 2174846:DDW44_RS26325
uniprot id: A0A2S1SZS2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

2174846:DDW44 RS02445
gene id: 2174846:DDW44_RS02445
uniprot id: A0A2S1SMX7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

2174846:DDW44 RS20590
gene id: 2174846:DDW44_RS20590
uniprot id: A0A2S1SWV8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2174846:DDW44 RS01410
gene id: 2174846:DDW44_RS01410
uniprot id: A0A2S1SMG8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

2174846:DDW44 RS17615
gene id: 2174846:DDW44_RS17615
uniprot id: A0A2S1SVF7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2174846:DDW44 RS16710
gene id: 2174846:DDW44_RS16710
uniprot id: A0A2S1SVC6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

2174846:DDW44 RS10205
gene id: 2174846:DDW44_RS10205
uniprot id: A0A2S1SRU9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

2174846:DDW44 RS11625
gene id: 2174846:DDW44_RS11625
uniprot id: A0A2S1SSJ3
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

2174846:DDW44 RS13770
gene id: 2174846:DDW44_RS13770
uniprot id: A0A2S1STN1
names: Subcellular Location Annotation
messages: Cytoplasm

2174846:DDW44 RS12285
gene id: 2174846:DDW44_RS12285
uniprot id: A0A2S1SSW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.

2174846:DDW44 RS11620
gene id: 2174846:DDW44_RS11620
uniprot id: A0A2S1SSM7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.
messages: Cell membrane
messages: Contains a di-nuclear catalytic Mg(2+) center.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

2174846:DDW44 RS15190
gene id: 2174846:DDW44_RS15190
uniprot id: A0A2S1SU81
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS05435
gene id: 2174846:DDW44_RS05435
uniprot id: A0A2S1SPH0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

2174846:DDW44 RS03620
gene id: 2174846:DDW44_RS03620
uniprot id: A0A2S1SNK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

2174846:DDW44 RS15815
gene id: 2174846:DDW44_RS15815
uniprot id: A0A2S1SUM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.

2174846:DDW44 RS09755
gene id: 2174846:DDW44_RS09755
uniprot id: A0A2S1SRV4
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

2174846:DDW44 RS25410
gene id: 2174846:DDW44_RS25410
uniprot id: A0A2S1SZF4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2174846:DDW44 RS20080
gene id: 2174846:DDW44_RS20080
uniprot id: A0A2S1SWN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS22005
gene id: 2174846:DDW44_RS22005
uniprot id: A0A2S1SXQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

2174846:DDW44 RS09030
gene id: 2174846:DDW44_RS09030
uniprot id: A0A2S1SR87
names: Similarity
messages: Belongs to the universal stress protein A family.

2174846:DDW44 RS17425
gene id: 2174846:DDW44_RS17425
uniprot id: A0A2S1SVQ2
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

2174846:DDW44 RS11195
gene id: 2174846:DDW44_RS11195
uniprot id: A0A2S1SSC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbxX/CfxQ family.
messages: Cytoplasm

2174846:DDW44 RS07965
gene id: 2174846:DDW44_RS07965
uniprot id: A0A2S1SQQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M4 family.
messages: Extracellular zinc metalloprotease.
messages: Secreted

2174846:DDW44 RS10425
gene id: 2174846:DDW44_RS10425
uniprot id: A0A2S1SRX6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

2174846:DDW44 RS21175
gene id: 2174846:DDW44_RS21175
uniprot id: A0A2S1SX76
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

2174846:DDW44 RS00735
gene id: 2174846:DDW44_RS00735
uniprot id: A0A2S1SM31
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

2174846:DDW44 RS27005
gene id: 2174846:DDW44_RS27005
uniprot id: A0A2S1T041
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

2174846:DDW44 RS20375
gene id: 2174846:DDW44_RS20375
uniprot id: A0A2S1SWY0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

2174846:DDW44 RS06140
gene id: 2174846:DDW44_RS06140
uniprot id: A0A2S1SPW0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS14165
gene id: 2174846:DDW44_RS14165
uniprot id: A0A2S1STS9
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

2174846:DDW44 RS15520
gene id: 2174846:DDW44_RS15520
uniprot id: A0A2S1SUE5
names: Similarity
messages: Belongs to the peptidase S11 family.

2174846:DDW44 RS03540
gene id: 2174846:DDW44_RS03540
uniprot id: A0A2S1SNI5
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

2174846:DDW44 RS03475
gene id: 2174846:DDW44_RS03475
uniprot id: A0A2S1SNK7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

2174846:DDW44 RS02815
gene id: 2174846:DDW44_RS02815
uniprot id: A0A2S1SN61
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

2174846:DDW44 RS27855
gene id: 2174846:DDW44_RS27855
uniprot id: A0A2S1T0L2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

2174846:DDW44 RS04055
gene id: 2174846:DDW44_RS04055
uniprot id: A0A2S1SNT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS12870
gene id: 2174846:DDW44_RS12870
uniprot id: A0A2S1ST44
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS10165
gene id: 2174846:DDW44_RS10165
uniprot id: A0A2S1SRS9
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

2174846:DDW44 RS02190
gene id: 2174846:DDW44_RS02190
uniprot id: A0A2S1SMT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

2174846:DDW44 RS16435
gene id: 2174846:DDW44_RS16435
uniprot id: A0A2S1SUV8
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

2174846:DDW44 RS21065
gene id: 2174846:DDW44_RS21065
uniprot id: A0A2S1SX56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

2174846:DDW44 RS31455
gene id: 2174846:DDW44_RS31455
uniprot id: A0A2S1T2G7
names: Similarity
messages: Belongs to the cytochrome P450 family.

2174846:DDW44 RS10155
gene id: 2174846:DDW44_RS10155
uniprot id: A0A2S1SRT9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

2174846:DDW44 RS23270
gene id: 2174846:DDW44_RS23270
uniprot id: A0A2S1SY63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

2174846:DDW44 RS10815
gene id: 2174846:DDW44_RS10815
uniprot id: A0A2S1SS30
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2174846:DDW44 RS18585
gene id: 2174846:DDW44_RS18585
uniprot id: A0A2S1SVW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2174846:DDW44 RS12470
gene id: 2174846:DDW44_RS12470
uniprot id: A0A2S1ST02
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase involved in purine salvage.

2174846:DDW44 RS06640
gene id: 2174846:DDW44_RS06640
uniprot id: A0A2S1SQ46
names: Similarity
messages: Belongs to the CsoR family.

2174846:DDW44 RS17065
gene id: 2174846:DDW44_RS17065
uniprot id: A0A2S1SV59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

2174846:DDW44 RS02960
gene id: 2174846:DDW44_RS02960
uniprot id: A0A2S1SN77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

2174846:DDW44 RS14420
gene id: 2174846:DDW44_RS14420
uniprot id: A0A2S1STU9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

2174846:DDW44 RS22370
gene id: 2174846:DDW44_RS22370
uniprot id: A0A2S1SXR3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

2174846:DDW44 RS08275
gene id: 2174846:DDW44_RS08275
uniprot id: A0A2S1SQX0
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

2174846:DDW44 RS14195
gene id: 2174846:DDW44_RS14195
uniprot id: A0A2S1SU40
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

2174846:DDW44 RS22085
gene id: 2174846:DDW44_RS22085
uniprot id: A0A2S1SXS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

2174846:DDW44 RS07720
gene id: 2174846:DDW44_RS07720
uniprot id: A0A2S1SQT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

2174846:DDW44 RS07930
gene id: 2174846:DDW44_RS07930
uniprot id: A0A2S1SQN3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

2174846:DDW44 RS28890
gene id: 2174846:DDW44_RS28890
uniprot id: A0A2S1T1J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

2174846:DDW44 RS08065
gene id: 2174846:DDW44_RS08065
uniprot id: A0A2S1SQS8
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

2174846:DDW44 RS20435
gene id: 2174846:DDW44_RS20435
uniprot id: A0A2S1SX78
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

2174846:DDW44 RS09950
gene id: 2174846:DDW44_RS09950
uniprot id: A0A2S1SRP8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

2174846:DDW44 RS28010
gene id: 2174846:DDW44_RS28010
uniprot id: A0A2S1T3G0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

2174846:DDW44 RS05170
gene id: 2174846:DDW44_RS05170
uniprot id: A0A2S1SPD5
names: Function
names: Similarity
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.

2174846:DDW44 RS27655
gene id: 2174846:DDW44_RS27655
uniprot id: A0A2S1T0K4
names: Similarity
messages: Belongs to the Rho GDI family.

2174846:DDW44 RS27015
gene id: 2174846:DDW44_RS27015
uniprot id: A0A2S1T048
names: Cofactor
names: Similarity
messages: Belongs to the fatty acid desaturase type 2 family.
messages: Binds 2 iron ions per subunit.

2174846:DDW44 RS27180
gene id: 2174846:DDW44_RS27180
uniprot id: A0A2S1T070
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

2174846:DDW44 RS27910
gene id: 2174846:DDW44_RS27910
uniprot id: A0A2S1T0Q4
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

2174846:DDW44 RS14930
gene id: 2174846:DDW44_RS14930
uniprot id: A0A2S1SU65
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

2174846:DDW44 RS16680
gene id: 2174846:DDW44_RS16680
uniprot id: A0A2S1SUZ7
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

2174846:DDW44 RS23965
gene id: 2174846:DDW44_RS23965
uniprot id: A0A2S1SYL9
names: Similarity
messages: Belongs to the AHA1 family.

2174846:DDW44 RS18505
gene id: 2174846:DDW44_RS18505
uniprot id: A0A2S1SW95
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

2174846:DDW44 RS18935
gene id: 2174846:DDW44_RS18935
uniprot id: A0A2S1SW52
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS17475
gene id: 2174846:DDW44_RS17475
uniprot id: A0A2S1SVF3
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

2174846:DDW44 RS10175
gene id: 2174846:DDW44_RS10175
uniprot id: A0A2S1SRY4
names: Similarity
messages: Belongs to the UPF0434 family.

2174846:DDW44 RS10210
gene id: 2174846:DDW44_RS10210
uniprot id: A0A2S1SRU7
names: Similarity
messages: Belongs to the cysteine dioxygenase family.

2174846:DDW44 RS11220
gene id: 2174846:DDW44_RS11220
uniprot id: A0A2S1SSA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

2174846:DDW44 RS16795
gene id: 2174846:DDW44_RS16795
uniprot id: A0A2S1SV10
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

2174846:DDW44 RS17505
gene id: 2174846:DDW44_RS17505
uniprot id: A0A2S1SVD4
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS11280
gene id: 2174846:DDW44_RS11280
uniprot id: A0A2S1SSB9
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

2174846:DDW44 RS14845
gene id: 2174846:DDW44_RS14845
uniprot id: A0A2S1SU27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SsgA family.
messages: Cell septum

2174846:DDW44 RS02325
gene id: 2174846:DDW44_RS02325
uniprot id: A0A2S1SMY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

2174846:DDW44 RS29040
gene id: 2174846:DDW44_RS29040
uniprot id: A0A2S1T143
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

2174846:DDW44 RS16745
gene id: 2174846:DDW44_RS16745
uniprot id: A0A2S1SV03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

2174846:DDW44 RS07435
gene id: 2174846:DDW44_RS07435
uniprot id: A0A2S1SQG5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.

2174846:DDW44 RS10445
gene id: 2174846:DDW44_RS10445
uniprot id: A0A2S1SRZ5
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

2174846:DDW44 RS15170
gene id: 2174846:DDW44_RS15170
uniprot id: A0A2S1SUA9
names: Similarity
messages: Belongs to the thioesterase family.

2174846:DDW44 RS23185
gene id: 2174846:DDW44_RS23185
uniprot id: A0A2S1T3S2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

2174846:DDW44 RS08375
gene id: 2174846:DDW44_RS08375
uniprot id: A0A2S1SQY3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

2174846:DDW44 RS01715
gene id: 2174846:DDW44_RS01715
uniprot id: A0A2S1SMK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

2174846:DDW44 RS17640
gene id: 2174846:DDW44_RS17640
uniprot id: A0A2S1SVI5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS22400
gene id: 2174846:DDW44_RS22400
uniprot id: A0A2S1SXW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2174846:DDW44 RS23275
gene id: 2174846:DDW44_RS23275
uniprot id: A0A2S1SYA9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

2174846:DDW44 RS02255
gene id: 2174846:DDW44_RS02255
uniprot id: A0A2S1SMY3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic ubiquitin-like protein family.
messages: Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.
messages: Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
messages: Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.
messages: The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.

2174846:DDW44 RS11595
gene id: 2174846:DDW44_RS11595
uniprot id: A0A2S1SSI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

2174846:DDW44 RS17635
gene id: 2174846:DDW44_RS17635
uniprot id: A0A2S1SVG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

2174846:DDW44 RS29375
gene id: 2174846:DDW44_RS29375
uniprot id: A0A2S1T1A5
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

2174846:DDW44 RS08160
gene id: 2174846:DDW44_RS08160
uniprot id: A0A2S1SR25
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

2174846:DDW44 RS09225
gene id: 2174846:DDW44_RS09225
uniprot id: A0A2S1SRC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS04290
gene id: 2174846:DDW44_RS04290
uniprot id: A0A2S1SNX8
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS00785
gene id: 2174846:DDW44_RS00785
uniprot id: A0A2S1SM85
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

2174846:DDW44 RS03885
gene id: 2174846:DDW44_RS03885
uniprot id: A0A2S1SNQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterioferritin family.
messages: Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

2174846:DDW44 RS01690
gene id: 2174846:DDW44_RS01690
uniprot id: A0A2S1SML6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

2174846:DDW44 RS15055
gene id: 2174846:DDW44_RS15055
uniprot id: A0A2S1SU61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

2174846:DDW44 RS16770
gene id: 2174846:DDW44_RS16770
uniprot id: A0A2S1SV41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

2174846:DDW44 RS19635
gene id: 2174846:DDW44_RS19635
uniprot id: A0A2S1SWF1
names: Similarity
messages: Belongs to the FBPase class 2 family.

2174846:DDW44 RS22205
gene id: 2174846:DDW44_RS22205
uniprot id: A0A2S1SXN7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates guanosine-37 in various tRNAs.

2174846:DDW44 RS23020
gene id: 2174846:DDW44_RS23020
uniprot id: A0A2S1SY39
names: Similarity
messages: Belongs to the Dps family.

2174846:DDW44 RS14565
gene id: 2174846:DDW44_RS14565
uniprot id: A0A2S1SU86
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2174846:DDW44 RS19475
gene id: 2174846:DDW44_RS19475
uniprot id: A0A2S1SWI0
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS24070
gene id: 2174846:DDW44_RS24070
uniprot id: A0A2S1SYP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

2174846:DDW44 RS18125
gene id: 2174846:DDW44_RS18125
uniprot id: A0A2S1SVQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

2174846:DDW44 RS26700
gene id: 2174846:DDW44_RS26700
uniprot id: A0A2S1T024
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS04560
gene id: 2174846:DDW44_RS04560
uniprot id: A0A2S1SP65
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

2174846:DDW44 RS18070
gene id: 2174846:DDW44_RS18070
uniprot id: A0A2S1SVR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

2174846:DDW44 RS21415
gene id: 2174846:DDW44_RS21415
uniprot id: A0A2S1SXD0
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

2174846:DDW44 RS19660
gene id: 2174846:DDW44_RS19660
uniprot id: A0A2S1SWI7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

2174846:DDW44 RS18565
gene id: 2174846:DDW44_RS18565
uniprot id: A0A2S1SW02
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

2174846:DDW44 RS08385
gene id: 2174846:DDW44_RS08385
uniprot id: A0A2S1SQX1
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

2174846:DDW44 RS05525
gene id: 2174846:DDW44_RS05525
uniprot id: A0A2S1SPK4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

2174846:DDW44 RS29105
gene id: 2174846:DDW44_RS29105
uniprot id: A0A2S1T1N4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

2174846:DDW44 RS18010
gene id: 2174846:DDW44_RS18010
uniprot id: A0A2S1SVQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

2174846:DDW44 RS07400
gene id: 2174846:DDW44_RS07400
uniprot id: A0A2S1SQH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS11390
gene id: 2174846:DDW44_RS11390
uniprot id: A0A2S1SSD2
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

2174846:DDW44 RS21035
gene id: 2174846:DDW44_RS21035
uniprot id: A0A2S1SX54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

2174846:DDW44 RS26035
gene id: 2174846:DDW44_RS26035
uniprot id: A0A2S1SZQ8
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS18530
gene id: 2174846:DDW44_RS18530
uniprot id: A0A2S1SVV8
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

2174846:DDW44 RS22315
gene id: 2174846:DDW44_RS22315
uniprot id: A0A2S1SXS9
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

2174846:DDW44 RS09645
gene id: 2174846:DDW44_RS09645
uniprot id: A0A2S1SRT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SsgA family.
messages: Cell septum

2174846:DDW44 RS20750
gene id: 2174846:DDW44_RS20750
uniprot id: A0A2S1SWY7
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

2174846:DDW44 RS12565
gene id: 2174846:DDW44_RS12565
uniprot id: A0A2S1SSZ4
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

2174846:DDW44 RS25490
gene id: 2174846:DDW44_RS25490
uniprot id: A0A2S1T3F4
names: Cofactor
messages: Can also use Mn(2+) ion.

2174846:DDW44 RS03635
gene id: 2174846:DDW44_RS03635
uniprot id: A0A2S1SNK0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

2174846:DDW44 RS29490
gene id: 2174846:DDW44_RS29490
uniprot id: A0A2S1T1C6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

2174846:DDW44 RS03015
gene id: 2174846:DDW44_RS03015
uniprot id: A0A2S1SN90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

2174846:DDW44 RS07405
gene id: 2174846:DDW44_RS07405
uniprot id: A0A2S1SQG8
names: Similarity
messages: Belongs to the band 7/mec-2 family.

2174846:DDW44 RS20965
gene id: 2174846:DDW44_RS20965
uniprot id: A0A2S1SX49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

2174846:DDW44 RS16905
gene id: 2174846:DDW44_RS16905
uniprot id: A0A2S1SV26
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS17030
gene id: 2174846:DDW44_RS17030
uniprot id: A0A2S1SV69
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS18030
gene id: 2174846:DDW44_RS18030
uniprot id: A0A2S1SVM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

2174846:DDW44 RS12415
gene id: 2174846:DDW44_RS12415
uniprot id: A0A2S1SSZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

2174846:DDW44 RS20960
gene id: 2174846:DDW44_RS20960
uniprot id: A0A2S1SX43
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

2174846:DDW44 RS02800
gene id: 2174846:DDW44_RS02800
uniprot id: A0A2S1SN85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS26540
gene id: 2174846:DDW44_RS26540
uniprot id: A0A2S1SZX4
names: Similarity
messages: Belongs to the cysteine dioxygenase family.

2174846:DDW44 RS21855
gene id: 2174846:DDW44_RS21855
uniprot id: A0A2S1SXG8
names: Similarity
messages: Belongs to the agmatine deiminase family.

2174846:DDW44 RS18725
gene id: 2174846:DDW44_RS18725
uniprot id: A0A2S1SW13
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

2174846:DDW44 RS14945
gene id: 2174846:DDW44_RS14945
uniprot id: A0A2S1SU53
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

2174846:DDW44 RS08005
gene id: 2174846:DDW44_RS08005
uniprot id: A0A2S1SQZ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

2174846:DDW44 RS03260
gene id: 2174846:DDW44_RS03260
uniprot id: A0A2S1SND9
names: Similarity
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.

2174846:DDW44 RS21440
gene id: 2174846:DDW44_RS21440
uniprot id: A0A2S1SXR9
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

2174846:DDW44 RS22260
gene id: 2174846:DDW44_RS22260
uniprot id: A0A2S1SXP7
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

2174846:DDW44 RS18090
gene id: 2174846:DDW44_RS18090
uniprot id: A0A2S1SVM9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

2174846:DDW44 RS04035
gene id: 2174846:DDW44_RS04035
uniprot id: A0A2S1SNS4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS02835
gene id: 2174846:DDW44_RS02835
uniprot id: A0A2S1SN52
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

2174846:DDW44 RS16765
gene id: 2174846:DDW44_RS16765
uniprot id: A0A2S1SVD6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

2174846:DDW44 RS22215
gene id: 2174846:DDW44_RS22215
uniprot id: A0A2S1SXU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

2174846:DDW44 RS18310
gene id: 2174846:DDW44_RS18310
uniprot id: A0A2S1SVU3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

2174846:DDW44 RS03700
gene id: 2174846:DDW44_RS03700
uniprot id: A0A2S1SNL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

2174846:DDW44 RS17935
gene id: 2174846:DDW44_RS17935
uniprot id: A0A2S1SVZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

2174846:DDW44 RS18075
gene id: 2174846:DDW44_RS18075
uniprot id: A0A2S1SVP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

2174846:DDW44 RS04205
gene id: 2174846:DDW44_RS04205
uniprot id: A0A2S1SNW5
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

2174846:DDW44 RS30275
gene id: 2174846:DDW44_RS30275
uniprot id: A0A2S1T1T4
names: Similarity
messages: Belongs to the cytochrome P450 family.

2174846:DDW44 RS22235
gene id: 2174846:DDW44_RS22235
uniprot id: A0A2S1SXT8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

2174846:DDW44 RS11400
gene id: 2174846:DDW44_RS11400
uniprot id: A0A2S1SSP4
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS17415
gene id: 2174846:DDW44_RS17415
uniprot id: A0A2S1SVC7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

2174846:DDW44 RS02945
gene id: 2174846:DDW44_RS02945
uniprot id: A0A2S1SN69
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

2174846:DDW44 RS26025
gene id: 2174846:DDW44_RS26025
uniprot id: A0A2S1SZL4
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS19570
gene id: 2174846:DDW44_RS19570
uniprot id: A0A2S1SWE9
names: Function
names: Similarity
names: Subunit
messages: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
messages: Belongs to the AhpD family.
messages: Homotrimer.

2174846:DDW44 RS11870
gene id: 2174846:DDW44_RS11870
uniprot id: A0A2S1SSR3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

2174846:DDW44 RS02175
gene id: 2174846:DDW44_RS02175
uniprot id: A0A2S1SMV6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2174846:DDW44 RS21480
gene id: 2174846:DDW44_RS21480
uniprot id: A0A2S1T3G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS03640
gene id: 2174846:DDW44_RS03640
uniprot id: A0A2S1SNN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

2174846:DDW44 RS04045
gene id: 2174846:DDW44_RS04045
uniprot id: A0A2S1SNT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Cell membrane
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.
messages: Membrane

2174846:DDW44 RS02820
gene id: 2174846:DDW44_RS02820
uniprot id: A0A2S1SN68
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

2174846:DDW44 RS07505
gene id: 2174846:DDW44_RS07505
uniprot id: A0A2S1SQI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

2174846:DDW44 RS27010
gene id: 2174846:DDW44_RS27010
uniprot id: A0A2S1T3X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan.
messages: Belongs to the glycosyl hydrolase 46 family.
messages: Secreted

2174846:DDW44 RS07275
gene id: 2174846:DDW44_RS07275
uniprot id: A0A2S1SQC0
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS06190
gene id: 2174846:DDW44_RS06190
uniprot id: A0A2S1SPV4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS17915
gene id: 2174846:DDW44_RS17915
uniprot id: A0A2S1SVL1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

2174846:DDW44 RS07830
gene id: 2174846:DDW44_RS07830
uniprot id: A0A2S1SQP5
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

2174846:DDW44 RS27425
gene id: 2174846:DDW44_RS27425
uniprot id: A0A2S1T0A9
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

2174846:DDW44 RS20055
gene id: 2174846:DDW44_RS20055
uniprot id: A0A2S1SWN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

2174846:DDW44 RS00955
gene id: 2174846:DDW44_RS00955
uniprot id: A0A2S1SM73
names: Similarity
messages: Belongs to the HupF/HypC family.

2174846:DDW44 RS30180
gene id: 2174846:DDW44_RS30180
uniprot id: A0A2S1T1W1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

2174846:DDW44 RS17930
gene id: 2174846:DDW44_RS17930
uniprot id: A0A2S1SVP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

2174846:DDW44 RS17510
gene id: 2174846:DDW44_RS17510
uniprot id: A0A2S1SVE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

2174846:DDW44 RS01085
gene id: 2174846:DDW44_RS01085
uniprot id: A0A2S1SMD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

2174846:DDW44 RS04990
gene id: 2174846:DDW44_RS04990
uniprot id: A0A2S1SPA4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

2174846:DDW44 RS10535
gene id: 2174846:DDW44_RS10535
uniprot id: A0A2S1SRY0
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

2174846:DDW44 RS21560
gene id: 2174846:DDW44_RS21560
uniprot id: A0A2S1T391
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

2174846:DDW44 RS04080
gene id: 2174846:DDW44_RS04080
uniprot id: A0A2S1T2J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

2174846:DDW44 RS10350
gene id: 2174846:DDW44_RS10350
uniprot id: A0A2S1SS13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

2174846:DDW44 RS06085
gene id: 2174846:DDW44_RS06085
uniprot id: A0A2S1SPV0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

2174846:DDW44 RS09460
gene id: 2174846:DDW44_RS09460
uniprot id: A0A2S1SRG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Heptamer of 7 subunits arranged in a ring.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

2174846:DDW44 RS06620
gene id: 2174846:DDW44_RS06620
uniprot id: A0A2S1SQ13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

2174846:DDW44 RS19065
gene id: 2174846:DDW44_RS19065
uniprot id: A0A2S1SW69
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.

2174846:DDW44 RS24455
gene id: 2174846:DDW44_RS24455
uniprot id: A0A2S1SYV9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS18005
gene id: 2174846:DDW44_RS18005
uniprot id: A0A2S1SW01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

2174846:DDW44 RS11345
gene id: 2174846:DDW44_RS11345
uniprot id: A0A2S1SSN7
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

2174846:DDW44 RS26565
gene id: 2174846:DDW44_RS26565
uniprot id: A0A2S1SZW7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

2174846:DDW44 RS21740
gene id: 2174846:DDW44_RS21740
uniprot id: A0A2S1SXK2
names: Similarity
messages: Belongs to the group II decarboxylase family.

2174846:DDW44 RS08395
gene id: 2174846:DDW44_RS08395
uniprot id: A0A2S1T2P7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

2174846:DDW44 RS11455
gene id: 2174846:DDW44_RS11455
uniprot id: A0A2S1SSH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

2174846:DDW44 RS06495
gene id: 2174846:DDW44_RS06495
uniprot id: A0A2S1SPZ5
names: Caution
names: Similarity
messages: Belongs to the nitrobindin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lacks the conserved His residue that binds heme iron in the nitrobindin family.

2174846:DDW44 RS19480
gene id: 2174846:DDW44_RS19480
uniprot id: A0A2S1SWR7
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS17430
gene id: 2174846:DDW44_RS17430
uniprot id: A0A2S1SVF2
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

2174846:DDW44 RS12065
gene id: 2174846:DDW44_RS12065
uniprot id: A0A2S1SSS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

2174846:DDW44 RS14115
gene id: 2174846:DDW44_RS14115
uniprot id: A0A2S1STR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

2174846:DDW44 RS00235
gene id: 2174846:DDW44_RS00235
uniprot id: A0A2S1SLW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2174846:DDW44 RS15595
gene id: 2174846:DDW44_RS15595
uniprot id: A0A2S1SUR4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

2174846:DDW44 RS00940
gene id: 2174846:DDW44_RS00940
uniprot id: A0A2S1SM48
names: Similarity
messages: Belongs to the CdaR family.

2174846:DDW44 RS08445
gene id: 2174846:DDW44_RS08445
uniprot id: A0A2S1SQZ5
names: Similarity
messages: Belongs to the LacAB/RpiB family.

2174846:DDW44 RS18020
gene id: 2174846:DDW44_RS18020
uniprot id: A0A2S1SVP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

2174846:DDW44 RS30305
gene id: 2174846:DDW44_RS30305
uniprot id: A0A2S1T1Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

2174846:DDW44 RS04070
gene id: 2174846:DDW44_RS04070
uniprot id: A0A2S1SNT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

2174846:DDW44 RS18620
gene id: 2174846:DDW44_RS18620
uniprot id: A0A2S1SVY5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

2174846:DDW44 RS20230
gene id: 2174846:DDW44_RS20230
uniprot id: A0A2S1SWR6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: Nucleus
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

2174846:DDW44 RS11580
gene id: 2174846:DDW44_RS11580
uniprot id: A0A2S1SSJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

2174846:DDW44 RS26545
gene id: 2174846:DDW44_RS26545
uniprot id: A0A2S1T003
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2174846:DDW44 RS12135
gene id: 2174846:DDW44_RS12135
uniprot id: A0A2S1SSR9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS11060
gene id: 2174846:DDW44_RS11060
uniprot id: A0A2S1SS73
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS11335
gene id: 2174846:DDW44_RS11335
uniprot id: A0A2S1SSC1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

2174846:DDW44 RS28360
gene id: 2174846:DDW44_RS28360
uniprot id: A0A2S1T0R7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2174846:DDW44 RS16675
gene id: 2174846:DDW44_RS16675
uniprot id: A0A2S1SUZ5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

2174846:DDW44 RS17945
gene id: 2174846:DDW44_RS17945
uniprot id: A0A2S1SVN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

2174846:DDW44 RS28365
gene id: 2174846:DDW44_RS28365
uniprot id: A0A2S1T0U1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer.
messages: In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.
messages: In the N-terminal section; belongs to the LPG synthetase family.
messages: Membrane

2174846:DDW44 RS03295
gene id: 2174846:DDW44_RS03295
uniprot id: A0A2S1SND7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

2174846:DDW44 RS02195
gene id: 2174846:DDW44_RS02195
uniprot id: A0A2S1SMR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

2174846:DDW44 RS19745
gene id: 2174846:DDW44_RS19745
uniprot id: A0A2S1SWG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2174846:DDW44 RS05165
gene id: 2174846:DDW44_RS05165
uniprot id: A0A2S1SPE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

2174846:DDW44 RS12070
gene id: 2174846:DDW44_RS12070
uniprot id: A0A2S1SSS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

2174846:DDW44 RS10270
gene id: 2174846:DDW44_RS10270
uniprot id: A0A2S1SRV2
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

2174846:DDW44 RS24890
gene id: 2174846:DDW44_RS24890
uniprot id: A0A2S1SZ11
names: Similarity
messages: Belongs to the TPP enzyme family.

2174846:DDW44 RS27755
gene id: 2174846:DDW44_RS27755
uniprot id: A0A2S1T0M4
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

2174846:DDW44 RS19195
gene id: 2174846:DDW44_RS19195
uniprot id: A0A2S1SW82
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

2174846:DDW44 RS21055
gene id: 2174846:DDW44_RS21055
uniprot id: A0A2S1SX82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

2174846:DDW44 RS03825
gene id: 2174846:DDW44_RS03825
uniprot id: A0A2S1SNQ4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS08510
gene id: 2174846:DDW44_RS08510
uniprot id: A0A2S1SR11
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

2174846:DDW44 RS26125
gene id: 2174846:DDW44_RS26125
uniprot id: A0A2S1SZQ5
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

2174846:DDW44 RS21180
gene id: 2174846:DDW44_RS21180
uniprot id: A0A2S1SX64
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

2174846:DDW44 RS26695
gene id: 2174846:DDW44_RS26695
uniprot id: A0A2S1SZY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

2174846:DDW44 RS24675
gene id: 2174846:DDW44_RS24675
uniprot id: A0A2S1SZD5
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS29470
gene id: 2174846:DDW44_RS29470
uniprot id: A0A2S1T1D8
names: Similarity
messages: Belongs to the universal stress protein A family.

2174846:DDW44 RS09605
gene id: 2174846:DDW44_RS09605
uniprot id: A0A2S1SRH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

2174846:DDW44 RS03390
gene id: 2174846:DDW44_RS03390
uniprot id: A0A2S1SNG1
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS10915
gene id: 2174846:DDW44_RS10915
uniprot id: A0A2S1SS99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sbp family.
messages: Cell membrane

2174846:DDW44 RS22195
gene id: 2174846:DDW44_RS22195
uniprot id: A0A2S1SXR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A probable RNA-binding protein.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm

2174846:DDW44 RS07410
gene id: 2174846:DDW44_RS07410
uniprot id: A0A2S1SQH4
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS13665
gene id: 2174846:DDW44_RS13665
uniprot id: A0A2S1STK4
names: Similarity
messages: Belongs to the CutC family.

2174846:DDW44 RS02225
gene id: 2174846:DDW44_RS02225
uniprot id: A0A2S1SMW9
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

2174846:DDW44 RS22915
gene id: 2174846:DDW44_RS22915
uniprot id: A0A2S1SY54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

2174846:DDW44 RS20990
gene id: 2174846:DDW44_RS20990
uniprot id: A0A2S1SX88
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

2174846:DDW44 RS14810
gene id: 2174846:DDW44_RS14810
uniprot id: A0A2S1SU33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

2174846:DDW44 RS18025
gene id: 2174846:DDW44_RS18025
uniprot id: A0A2S1SVM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

2174846:DDW44 RS17975
gene id: 2174846:DDW44_RS17975
uniprot id: A0A2S1SVM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

2174846:DDW44 RS09465
gene id: 2174846:DDW44_RS09465
uniprot id: A0A2S1SRD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS18320
gene id: 2174846:DDW44_RS18320
uniprot id: A0A2S1SW66
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2174846:DDW44 RS18925
gene id: 2174846:DDW44_RS18925
uniprot id: A0A2S1SW29
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS22280
gene id: 2174846:DDW44_RS22280
uniprot id: A0A2S1SYA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

2174846:DDW44 RS18295
gene id: 2174846:DDW44_RS18295
uniprot id: A0A2S1SVR8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

2174846:DDW44 RS24775
gene id: 2174846:DDW44_RS24775
uniprot id: A0A2S1SZ17
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

2174846:DDW44 RS14940
gene id: 2174846:DDW44_RS14940
uniprot id: A0A2S1SU47
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS06480
gene id: 2174846:DDW44_RS06480
uniprot id: A0A2S1SQ16
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

2174846:DDW44 RS01985
gene id: 2174846:DDW44_RS01985
uniprot id: A0A2S1SMM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

2174846:DDW44 RS24470
gene id: 2174846:DDW44_RS24470
uniprot id: A0A2S1SYV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

2174846:DDW44 RS16980
gene id: 2174846:DDW44_RS16980
uniprot id: A0A2S1SVH3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2174846:DDW44 RS18215
gene id: 2174846:DDW44_RS18215
uniprot id: A0A2S1SVU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

2174846:DDW44 RS21850
gene id: 2174846:DDW44_RS21850
uniprot id: A0A2S1SXK5
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: May form a heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits. May also form a heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

2174846:DDW44 RS27860
gene id: 2174846:DDW44_RS27860
uniprot id: A0A2S1T0P3
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

2174846:DDW44 RS02965
gene id: 2174846:DDW44_RS02965
uniprot id: A0A2S1SN83
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

2174846:DDW44 RS19160
gene id: 2174846:DDW44_RS19160
uniprot id: A0A2S1SW92
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

2174846:DDW44 RS17060
gene id: 2174846:DDW44_RS17060
uniprot id: A0A2S1SV66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS23580
gene id: 2174846:DDW44_RS23580
uniprot id: A0A2S1SYG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS28475
gene id: 2174846:DDW44_RS28475
uniprot id: A0A2S1T0W1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. EgtD family.
messages: Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine.
messages: Monomer.

2174846:DDW44 RS18055
gene id: 2174846:DDW44_RS18055
uniprot id: A0A2S1SW12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

2174846:DDW44 RS12760
gene id: 2174846:DDW44_RS12760
uniprot id: A0A2S1ST23
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS18095
gene id: 2174846:DDW44_RS18095
uniprot id: A0A2S1SVP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

2174846:DDW44 RS17885
gene id: 2174846:DDW44_RS17885
uniprot id: A0A2S1SVK6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

2174846:DDW44 RS17335
gene id: 2174846:DDW44_RS17335
uniprot id: A0A2S1SVB4
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS03695
gene id: 2174846:DDW44_RS03695
uniprot id: A0A2S1SNN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS14955
gene id: 2174846:DDW44_RS14955
uniprot id: A0A2S1SU37
names: Similarity
messages: Belongs to the FemABX family.

2174846:DDW44 RS08290
gene id: 2174846:DDW44_RS08290
uniprot id: A0A2S1SQW3
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.

2174846:DDW44 RS23045
gene id: 2174846:DDW44_RS23045
uniprot id: A0A2S1SY25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

2174846:DDW44 RS19435
gene id: 2174846:DDW44_RS19435
uniprot id: A0A2S1SWE5
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

2174846:DDW44 RS03615
gene id: 2174846:DDW44_RS03615
uniprot id: A0A2S1SNN8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

2174846:DDW44 RS21635
gene id: 2174846:DDW44_RS21635
uniprot id: A0A2S1SXF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

2174846:DDW44 RS21235
gene id: 2174846:DDW44_RS21235
uniprot id: A0A2S1SX89
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS03680
gene id: 2174846:DDW44_RS03680
uniprot id: A0A2S1SNL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS13120
gene id: 2174846:DDW44_RS13120
uniprot id: A0A2S1STA7
names: Similarity
messages: Belongs to the F420H(2)-dependent quinone reductase family.

2174846:DDW44 RS09365
gene id: 2174846:DDW44_RS09365
uniprot id: A0A2S1SRF3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

2174846:DDW44 RS20885
gene id: 2174846:DDW44_RS20885
uniprot id: A0A2S1SX26
names: Subunit
messages: Homodimer.

2174846:DDW44 RS13845
gene id: 2174846:DDW44_RS13845
uniprot id: A0A2S1STM9
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

2174846:DDW44 RS19975
gene id: 2174846:DDW44_RS19975
uniprot id: A0A2S1SWK6
names: Similarity
messages: Belongs to the LOG family.

2174846:DDW44 RS15715
gene id: 2174846:DDW44_RS15715
uniprot id: A0A2S1SUI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

2174846:DDW44 RS18040
gene id: 2174846:DDW44_RS18040
uniprot id: A0A2S1SVN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

2174846:DDW44 RS29170
gene id: 2174846:DDW44_RS29170
uniprot id: A0A2S1T1P4
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

2174846:DDW44 RS19955
gene id: 2174846:DDW44_RS19955
uniprot id: A0A2S1T3M7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

2174846:DDW44 RS05685
gene id: 2174846:DDW44_RS05685
uniprot id: A0A2S1SPK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

2174846:DDW44 RS07285
gene id: 2174846:DDW44_RS07285
uniprot id: A0A2S1SQF2
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

2174846:DDW44 RS22100
gene id: 2174846:DDW44_RS22100
uniprot id: A0A2S1SXM0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

2174846:DDW44 RS15590
gene id: 2174846:DDW44_RS15590
uniprot id: A0A2S1SUG5
names: Similarity
messages: Belongs to the peptidase M18 family.

2174846:DDW44 RS07865
gene id: 2174846:DDW44_RS07865
uniprot id: A0A2S1SQP7
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

2174846:DDW44 RS14400
gene id: 2174846:DDW44_RS14400
uniprot id: A0A2S1STV6
names: Similarity
messages: Belongs to the peptidase M28 family. M28A subfamily.

2174846:DDW44 RS07790
gene id: 2174846:DDW44_RS07790
uniprot id: A0A2S1T2Y6
names: Similarity
messages: Belongs to the CutA family.

2174846:DDW44 RS27825
gene id: 2174846:DDW44_RS27825
uniprot id: A0A2S1T0I6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

2174846:DDW44 RS20635
gene id: 2174846:DDW44_RS20635
uniprot id: A0A2S1SWX5
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

2174846:DDW44 RS18860
gene id: 2174846:DDW44_RS18860
uniprot id: A0A2S1SW43
names: Similarity
messages: Belongs to the BMP lipoprotein family.

2174846:DDW44 RS09860
gene id: 2174846:DDW44_RS09860
uniprot id: A0A2S1SRN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

2174846:DDW44 RS22200
gene id: 2174846:DDW44_RS22200
uniprot id: A0A2S1SXN4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

2174846:DDW44 RS18305
gene id: 2174846:DDW44_RS18305
uniprot id: A0A2S1SVS6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2174846:DDW44 RS13365
gene id: 2174846:DDW44_RS13365
uniprot id: A0A2S1STE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I16 (SSI) family.
messages: Homodimer.
messages: Secreted
messages: Strong inhibitor of bacterial serine proteases such as subtilisin.

2174846:DDW44 RS00750
gene id: 2174846:DDW44_RS00750
uniprot id: A0A2S1SM45
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS28755
gene id: 2174846:DDW44_RS28755
uniprot id: A0A2S1T107
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

2174846:DDW44 RS11140
gene id: 2174846:DDW44_RS11140
uniprot id: A0A2S1SSB4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Bind 1 Zn(2+) per subunit.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.

2174846:DDW44 RS11065
gene id: 2174846:DDW44_RS11065
uniprot id: A0A2S1SS80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

2174846:DDW44 RS15960
gene id: 2174846:DDW44_RS15960
uniprot id: A0A2S1SUM1
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

2174846:DDW44 RS27385
gene id: 2174846:DDW44_RS27385
uniprot id: A0A2S1T0C2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2174846:DDW44 RS23595
gene id: 2174846:DDW44_RS23595
uniprot id: A0A2S1SYW2
names: Subcellular Location Annotation
messages: Cell membrane

2174846:DDW44 RS25590
gene id: 2174846:DDW44_RS25590
uniprot id: A0A2S1SZE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

2174846:DDW44 RS01680
gene id: 2174846:DDW44_RS01680
uniprot id: A0A2S1SMP2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

2174846:DDW44 RS17600
gene id: 2174846:DDW44_RS17600
uniprot id: A0A2S1SVG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

2174846:DDW44 RS08105
gene id: 2174846:DDW44_RS08105
uniprot id: A0A2S1SR16
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

2174846:DDW44 RS29810
gene id: 2174846:DDW44_RS29810
uniprot id: A0A2S1T1I2
names: Subunit
messages: Homodimer.

2174846:DDW44 RS01745
gene id: 2174846:DDW44_RS01745
uniprot id: A0A2S1SMQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SsgA family.
messages: Cell septum

2174846:DDW44 RS28485
gene id: 2174846:DDW44_RS28485
uniprot id: A0A2S1T0V9
names: Function
names: Similarity
messages: Belongs to the EgtB family.
messages: Catalyzes the oxidative sulfurization of hercynine (N-alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.

2174846:DDW44 RS21585
gene id: 2174846:DDW44_RS21585
uniprot id: A0A2S1SXH2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

2174846:DDW44 RS28820
gene id: 2174846:DDW44_RS28820
uniprot id: A0A2S1T104
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gas vesicle protein type A family.
messages: Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure.
messages: gas vesicle membrane

2174846:DDW44 RS18665
gene id: 2174846:DDW44_RS18665
uniprot id: A0A2S1SW37
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS22190
gene id: 2174846:DDW44_RS22190
uniprot id: A0A2S1SXU0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

2174846:DDW44 RS26105
gene id: 2174846:DDW44_RS26105
uniprot id: A0A2S1SZN3
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

2174846:DDW44 RS30110
gene id: 2174846:DDW44_RS30110
uniprot id: A0A2S1T1N3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

2174846:DDW44 RS22290
gene id: 2174846:DDW44_RS22290
uniprot id: A0A2S1T3B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

2174846:DDW44 RS19950
gene id: 2174846:DDW44_RS19950
uniprot id: A0A2S1SWN9
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

2174846:DDW44 RS09865
gene id: 2174846:DDW44_RS09865
uniprot id: A0A2S1SRX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

2174846:DDW44 RS01450
gene id: 2174846:DDW44_RS01450
uniprot id: A0A2S1SMK3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

2174846:DDW44 RS18340
gene id: 2174846:DDW44_RS18340
uniprot id: A0A2S1T395
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

2174846:DDW44 RS04435
gene id: 2174846:DDW44_RS04435
uniprot id: A0A2S1SP03
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS07070
gene id: 2174846:DDW44_RS07070
uniprot id: A0A2S1SQB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

2174846:DDW44 RS07300
gene id: 2174846:DDW44_RS07300
uniprot id: A0A2S1SQF1
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

2174846:DDW44 RS29245
gene id: 2174846:DDW44_RS29245
uniprot id: A0A2S1T1A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

2174846:DDW44 RS24125
gene id: 2174846:DDW44_RS24125
uniprot id: A0A2S1SZ38
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

2174846:DDW44 RS28960
gene id: 2174846:DDW44_RS28960
uniprot id: A0A2S1T153
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

2174846:DDW44 RS11710
gene id: 2174846:DDW44_RS11710
uniprot id: A0A2S1SSM0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

2174846:DDW44 RS27045
gene id: 2174846:DDW44_RS27045
uniprot id: A0A2S1T062
names: Similarity
messages: Belongs to the YciI family.

2174846:DDW44 RS07975
gene id: 2174846:DDW44_RS07975
uniprot id: A0A2S1T2U3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

2174846:DDW44 RS23235
gene id: 2174846:DDW44_RS23235
uniprot id: A0A2S1SYQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

2174846:DDW44 RS08200
gene id: 2174846:DDW44_RS08200
uniprot id: A0A2S1SQV0
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

2174846:DDW44 RS23205
gene id: 2174846:DDW44_RS23205
uniprot id: A0A2S1SY48
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

2174846:DDW44 RS14745
gene id: 2174846:DDW44_RS14745
uniprot id: A0A2S1SU12
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS09785
gene id: 2174846:DDW44_RS09785
uniprot id: A0A2S1SRL6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2174846:DDW44 RS21500
gene id: 2174846:DDW44_RS21500
uniprot id: A0A2S1SXF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

2174846:DDW44 RS07905
gene id: 2174846:DDW44_RS07905
uniprot id: A0A2S1SQQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

2174846:DDW44 RS22135
gene id: 2174846:DDW44_RS22135
uniprot id: A0A2S1SXP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

2174846:DDW44 RS18730
gene id: 2174846:DDW44_RS18730
uniprot id: A0A2S1SW48
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

2174846:DDW44 RS30205
gene id: 2174846:DDW44_RS30205
uniprot id: A0A2S1T1S4
names: Similarity
messages: Belongs to the Fur family.

2174846:DDW44 RS17900
gene id: 2174846:DDW44_RS17900
uniprot id: A0A2S1SVL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

2174846:DDW44 RS20380
gene id: 2174846:DDW44_RS20380
uniprot id: A0A2S1SX65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

2174846:DDW44 RS26180
gene id: 2174846:DDW44_RS26180
uniprot id: A0A2S1SZN9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

2174846:DDW44 RS17180
gene id: 2174846:DDW44_RS17180
uniprot id: A0A2S1SV87
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

2174846:DDW44 RS08335
gene id: 2174846:DDW44_RS08335
uniprot id: A0A2S1SQW1
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS10305
gene id: 2174846:DDW44_RS10305
uniprot id: A0A2S1SRT8
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

2174846:DDW44 RS09850
gene id: 2174846:DDW44_RS09850
uniprot id: A0A2S1SRL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

2174846:DDW44 RS15090
gene id: 2174846:DDW44_RS15090
uniprot id: A0A2S1SU83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

2174846:DDW44 RS01700
gene id: 2174846:DDW44_RS01700
uniprot id: A0A2S1SMM8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS19470
gene id: 2174846:DDW44_RS19470
uniprot id: A0A2S1SWE6
names: Similarity
messages: Belongs to the GSP E family.

2174846:DDW44 RS08935
gene id: 2174846:DDW44_RS08935
uniprot id: A0A2S1SR80
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

2174846:DDW44 RS17655
gene id: 2174846:DDW44_RS17655
uniprot id: A0A2S1SVH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

2174846:DDW44 RS18120
gene id: 2174846:DDW44_RS18120
uniprot id: A0A2S1SVS5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

2174846:DDW44 RS05460
gene id: 2174846:DDW44_RS05460
uniprot id: A0A2S1SPI8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS19515
gene id: 2174846:DDW44_RS19515
uniprot id: A0A2S1SWC3
names: Similarity
messages: Belongs to the CdaR family.

2174846:DDW44 RS21645
gene id: 2174846:DDW44_RS21645
uniprot id: A0A2S1SXG6
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

2174846:DDW44 RS21170
gene id: 2174846:DDW44_RS21170
uniprot id: A0A2S1SX91
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

2174846:DDW44 RS01060
gene id: 2174846:DDW44_RS01060
uniprot id: A0A2S1SM93
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

2174846:DDW44 RS30060
gene id: 2174846:DDW44_RS30060
uniprot id: A0A2S1T3K4
names: Similarity
messages: Belongs to the CdaR family.

2174846:DDW44 RS14935
gene id: 2174846:DDW44_RS14935
uniprot id: A0A2S1SU34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

2174846:DDW44 RS02985
gene id: 2174846:DDW44_RS02985
uniprot id: A0A2S1SNC8
names: Function
names: Subcellular Location Annotation
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.
messages: Membrane

2174846:DDW44 RS18280
gene id: 2174846:DDW44_RS18280
uniprot id: A0A2S1SVT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

2174846:DDW44 RS21050
gene id: 2174846:DDW44_RS21050
uniprot id: A0A2S1SXJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

2174846:DDW44 RS16920
gene id: 2174846:DDW44_RS16920
uniprot id: A0A2S1SV36
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

2174846:DDW44 RS17340
gene id: 2174846:DDW44_RS17340
uniprot id: A0A2S1SVA7
names: Similarity
messages: Belongs to the UbiD family.

2174846:DDW44 RS11590
gene id: 2174846:DDW44_RS11590
uniprot id: A0A2S1SSH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

2174846:DDW44 RS20950
gene id: 2174846:DDW44_RS20950
uniprot id: A0A2S1SX70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

2174846:DDW44 RS26165
gene id: 2174846:DDW44_RS26165
uniprot id: A0A2S1SZT8
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

2174846:DDW44 RS22055
gene id: 2174846:DDW44_RS22055
uniprot id: A0A2S1T3C7
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

2174846:DDW44 RS03500
gene id: 2174846:DDW44_RS03500
uniprot id: A0A2S1SNL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Involved in both the histidine and tryptophan biosynthetic pathways.

2174846:DDW44 RS00520
gene id: 2174846:DDW44_RS00520
uniprot id: A0A2S1SLZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AmiS/UreI family.
messages: Membrane

2174846:DDW44 RS18085
gene id: 2174846:DDW44_RS18085
uniprot id: A0A2S1SVN8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

2174846:DDW44 RS18060
gene id: 2174846:DDW44_RS18060
uniprot id: A0A2S1T350
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

2174846:DDW44 RS21350
gene id: 2174846:DDW44_RS21350
uniprot id: A0A2S1SXA7
names: Similarity
names: Subunit
messages: Belongs to the aminoglycoside phosphotransferase family.
messages: Monomer.

2174846:DDW44 RS11555
gene id: 2174846:DDW44_RS11555
uniprot id: A0A2S1SSS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

2174846:DDW44 RS16720
gene id: 2174846:DDW44_RS16720
uniprot id: A0A2S1SUZ9
names: Similarity
messages: Belongs to the group II decarboxylase family.

2174846:DDW44 RS27050
gene id: 2174846:DDW44_RS27050
uniprot id: A0A2S1T093
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

2174846:DDW44 RS19550
gene id: 2174846:DDW44_RS19550
uniprot id: A0A2S1SWS7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS09045
gene id: 2174846:DDW44_RS09045
uniprot id: A0A2S1SRA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

2174846:DDW44 RS03335
gene id: 2174846:DDW44_RS03335
uniprot id: A0A2S1SNH9
names: Subcellular Location Annotation
messages: Cytoplasm

2174846:DDW44 RS26635
gene id: 2174846:DDW44_RS26635
uniprot id: A0A2S1T016
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2174846:DDW44 RS02045
gene id: 2174846:DDW44_RS02045
uniprot id: A0A2S1SMU3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

2174846:DDW44 RS07305
gene id: 2174846:DDW44_RS07305
uniprot id: A0A2S1SQD4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS13615
gene id: 2174846:DDW44_RS13615
uniprot id: A0A2S1STI7
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

2174846:DDW44 RS21870
gene id: 2174846:DDW44_RS21870
uniprot id: A0A2S1SXN5
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

2174846:DDW44 RS17960
gene id: 2174846:DDW44_RS17960
uniprot id: A0A2S1SVN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

2174846:DDW44 RS10430
gene id: 2174846:DDW44_RS10430
uniprot id: A0A2S1SRY1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

2174846:DDW44 RS13765
gene id: 2174846:DDW44_RS13765
uniprot id: A0A2S1STW0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

2174846:DDW44 RS17970
gene id: 2174846:DDW44_RS17970
uniprot id: A0A2S1SVL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

2174846:DDW44 RS03510
gene id: 2174846:DDW44_RS03510
uniprot id: A0A2S1SNH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

2174846:DDW44 RS21570
gene id: 2174846:DDW44_RS21570
uniprot id: A0A2S1SXG2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

2174846:DDW44 RS18015
gene id: 2174846:DDW44_RS18015
uniprot id: A0A2S1SVN2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

2174846:DDW44 RS27230
gene id: 2174846:DDW44_RS27230
uniprot id: A0A2S1T075
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS20485
gene id: 2174846:DDW44_RS20485
uniprot id: A0A2S1SWV5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS22245
gene id: 2174846:DDW44_RS22245
uniprot id: A0A2S1SXV0
names: Similarity
messages: Belongs to the UPF0102 family.

2174846:DDW44 RS27580
gene id: 2174846:DDW44_RS27580
uniprot id: A0A2S1T0W2
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS23005
gene id: 2174846:DDW44_RS23005
uniprot id: A0A2S1SYL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

2174846:DDW44 RS02110
gene id: 2174846:DDW44_RS02110
uniprot id: A0A2S1SMR3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

2174846:DDW44 RS17170
gene id: 2174846:DDW44_RS17170
uniprot id: A0A2S1SV73
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

2174846:DDW44 RS02370
gene id: 2174846:DDW44_RS02370
uniprot id: A0A2S1SMY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

2174846:DDW44 RS24385
gene id: 2174846:DDW44_RS24385
uniprot id: A0A2S1SYV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2174846:DDW44 RS18960
gene id: 2174846:DDW44_RS18960
uniprot id: A0A2S1SW65
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2174846:DDW44 RS21045
gene id: 2174846:DDW44_RS21045
uniprot id: A0A2S1SX99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

2174846:DDW44 RS18400
gene id: 2174846:DDW44_RS18400
uniprot id: A0A2S1SVV0
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS18330
gene id: 2174846:DDW44_RS18330
uniprot id: A0A2S1SVU0
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

2174846:DDW44 RS18780
gene id: 2174846:DDW44_RS18780
uniprot id: A0A2S1T3B7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2174846:DDW44 RS06070
gene id: 2174846:DDW44_RS06070
uniprot id: A0A2S1SPR9
names: Similarity
messages: Belongs to the pirin family.

2174846:DDW44 RS08860
gene id: 2174846:DDW44_RS08860
uniprot id: A0A2S1T2S4
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

2174846:DDW44 RS08400
gene id: 2174846:DDW44_RS08400
uniprot id: A0A2S1SR28
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

2174846:DDW44 RS22075
gene id: 2174846:DDW44_RS22075
uniprot id: A0A2S1SXQ7
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

2174846:DDW44 RS06225
gene id: 2174846:DDW44_RS06225
uniprot id: A0A2S1SPX0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

2174846:DDW44 RS12785
gene id: 2174846:DDW44_RS12785
uniprot id: A0A2S1ST31
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

2174846:DDW44 RS16690
gene id: 2174846:DDW44_RS16690
uniprot id: A0A2S1SUZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

2174846:DDW44 RS21835
gene id: 2174846:DDW44_RS21835
uniprot id: A0A2S1SXL7
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

2174846:DDW44 RS07235
gene id: 2174846:DDW44_RS07235
uniprot id: A0A2S1SQE9
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

2174846:DDW44 RS08190
gene id: 2174846:DDW44_RS08190
uniprot id: A0A2S1SQY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

2174846:DDW44 RS18135
gene id: 2174846:DDW44_RS18135
uniprot id: A0A2S1SVQ0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

2174846:DDW44 RS17920
gene id: 2174846:DDW44_RS17920
uniprot id: A0A2S1SVK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

2174846:DDW44 RS03135
gene id: 2174846:DDW44_RS03135
uniprot id: A0A2S1SND8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

2174846:DDW44 RS05325
gene id: 2174846:DDW44_RS05325
uniprot id: A0A2S1SPL6
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

2174846:DDW44 RS05295
gene id: 2174846:DDW44_RS05295
uniprot id: A0A2S1SPG1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS11875
gene id: 2174846:DDW44_RS11875
uniprot id: A0A2S1SSN0
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

2174846:DDW44 RS05725
gene id: 2174846:DDW44_RS05725
uniprot id: A0A2S1SPM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS21220
gene id: 2174846:DDW44_RS21220
uniprot id: A0A2S1SX90
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS08220
gene id: 2174846:DDW44_RS08220
uniprot id: A0A2S1SQW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

2174846:DDW44 RS21110
gene id: 2174846:DDW44_RS21110
uniprot id: A0A2S1SX72
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

2174846:DDW44 RS02230
gene id: 2174846:DDW44_RS02230
uniprot id: A0A2S1SMZ1
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
messages: Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
messages: The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.

2174846:DDW44 RS11585
gene id: 2174846:DDW44_RS11585
uniprot id: A0A2S1SSH1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

2174846:DDW44 RS12300
gene id: 2174846:DDW44_RS12300
uniprot id: A0A2S1ST49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SsgA family.
messages: Cell septum

2174846:DDW44 RS03650
gene id: 2174846:DDW44_RS03650
uniprot id: A0A2S1SNL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

2174846:DDW44 RS02220
gene id: 2174846:DDW44_RS02220
uniprot id: A0A2S1SMV5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

2174846:DDW44 RS02940
gene id: 2174846:DDW44_RS02940
uniprot id: A0A2S1SN70
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

2174846:DDW44 RS19205
gene id: 2174846:DDW44_RS19205
uniprot id: A0A2S1SW81
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.
messages: Belongs to the MshB deacetylase family. Mca subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Monomer.

2174846:DDW44 RS21060
gene id: 2174846:DDW44_RS21060
uniprot id: A0A2S1SX61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

2174846:DDW44 RS02330
gene id: 2174846:DDW44_RS02330
uniprot id: A0A2S1SN10
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS16445
gene id: 2174846:DDW44_RS16445
uniprot id: A0A2S1SUV0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

2174846:DDW44 RS25200
gene id: 2174846:DDW44_RS25200
uniprot id: A0A2S1SZB5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2174846:DDW44 RS18050
gene id: 2174846:DDW44_RS18050
uniprot id: A0A2S1SVR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

2174846:DDW44 RS30250
gene id: 2174846:DDW44_RS30250
uniprot id: A0A2S1T261
names: Similarity
messages: Belongs to the MmpS family.

2174846:DDW44 RS12290
gene id: 2174846:DDW44_RS12290
uniprot id: A0A2S1SSU2
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS20360
gene id: 2174846:DDW44_RS20360
uniprot id: A0A2S1SWS4
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

2174846:DDW44 RS19090
gene id: 2174846:DDW44_RS19090
uniprot id: A0A2S1SW60
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.
messages: Reversible hydration of carbon dioxide.

2174846:DDW44 RS06090
gene id: 2174846:DDW44_RS06090
uniprot id: A0A2S1SPY9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

2174846:DDW44 RS19125
gene id: 2174846:DDW44_RS19125
uniprot id: A0A2S1SW98
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

2174846:DDW44 RS24850
gene id: 2174846:DDW44_RS24850
uniprot id: A0A2S1SZH0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.

2174846:DDW44 RS21275
gene id: 2174846:DDW44_RS21275
uniprot id: A0A2S1SXA5
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

2174846:DDW44 RS27740
gene id: 2174846:DDW44_RS27740
uniprot id: A0A2S1T0K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS29475
gene id: 2174846:DDW44_RS29475
uniprot id: A0A2S1T1C8
names: Similarity
messages: Belongs to the peptidase S1 family.

2174846:DDW44 RS29650
gene id: 2174846:DDW44_RS29650
uniprot id: A0A2S1T1G6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2174846:DDW44 RS22930
gene id: 2174846:DDW44_RS22930
uniprot id: A0A2S1SY06
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

2174846:DDW44 RS04415
gene id: 2174846:DDW44_RS04415
uniprot id: A0A2S1SNZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2174846:DDW44 RS17870
gene id: 2174846:DDW44_RS17870
uniprot id: A0A2S1SVN0
names: Similarity
messages: Belongs to the UPF0336 family.

2174846:DDW44 RS10325
gene id: 2174846:DDW44_RS10325
uniprot id: A0A2S1SS72
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

2174846:DDW44 RS01965
gene id: 2174846:DDW44_RS01965
uniprot id: A0A2S1SMR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

2174846:DDW44 RS20985
gene id: 2174846:DDW44_RS20985
uniprot id: A0A2S1SX42
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

2174846:DDW44 RS07130
gene id: 2174846:DDW44_RS07130
uniprot id: A0A2S1SQB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

2174846:DDW44 RS12725
gene id: 2174846:DDW44_RS12725
uniprot id: A0A2S1T2W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

2174846:DDW44 RS19450
gene id: 2174846:DDW44_RS19450
uniprot id: A0A2S1SWC0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS18080
gene id: 2174846:DDW44_RS18080
uniprot id: A0A2S1SVQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

2174846:DDW44 RS08250
gene id: 2174846:DDW44_RS08250
uniprot id: A0A2S1SQW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

2174846:DDW44 RS24770
gene id: 2174846:DDW44_RS24770
uniprot id: A0A2S1T3I6
names: Caution
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS01685
gene id: 2174846:DDW44_RS01685
uniprot id: A0A2S1SMJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

2174846:DDW44 RS02270
gene id: 2174846:DDW44_RS02270
uniprot id: A0A2S1SMW8
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

2174846:DDW44 RS17610
gene id: 2174846:DDW44_RS17610
uniprot id: A0A2S1SVG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2174846:DDW44 RS25770
gene id: 2174846:DDW44_RS25770
uniprot id: A0A2S1SZL9
names: Function
names: Similarity
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.

2174846:DDW44 RS01865
gene id: 2174846:DDW44_RS01865
uniprot id: A0A2S1SML2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2174846:DDW44 RS20495
gene id: 2174846:DDW44_RS20495
uniprot id: A0A2S1SX85
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

2174846:DDW44 RS30005
gene id: 2174846:DDW44_RS30005
uniprot id: A0A2S1T1T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbxX/CfxQ family.
messages: Cytoplasm

2174846:DDW44 RS18165
gene id: 2174846:DDW44_RS18165
uniprot id: A0A2S1SVT1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

2174846:DDW44 RS02920
gene id: 2174846:DDW44_RS02920
uniprot id: A0A2S1SN81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

2174846:DDW44 RS15060
gene id: 2174846:DDW44_RS15060
uniprot id: A0A2S1SU57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

2174846:DDW44 RS13335
gene id: 2174846:DDW44_RS13335
uniprot id: A0A2S1STE4
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

2174846:DDW44 RS05095
gene id: 2174846:DDW44_RS05095
uniprot id: A0A2S1SPB9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

2174846:DDW44 RS18045
gene id: 2174846:DDW44_RS18045
uniprot id: A0A2S1SVN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

2174846:DDW44 RS11425
gene id: 2174846:DDW44_RS11425
uniprot id: A0A2S1SSH0
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

2174846:DDW44 RS09610
gene id: 2174846:DDW44_RS09610
uniprot id: A0A2S1SRN8
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

2174846:DDW44 RS06095
gene id: 2174846:DDW44_RS06095
uniprot id: A0A2S1SPS0
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

2174846:DDW44 RS17950
gene id: 2174846:DDW44_RS17950
uniprot id: A0A2S1SVM2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

2174846:DDW44 RS04020
gene id: 2174846:DDW44_RS04020
uniprot id: A0A2S1SNX0
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS03895
gene id: 2174846:DDW44_RS03895
uniprot id: A0A2S1SNV4
names: Similarity
messages: Belongs to the class-II DAHP synthase family.

2174846:DDW44 RS11850
gene id: 2174846:DDW44_RS11850
uniprot id: A0A2S1SSL6
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

2174846:DDW44 RS11215
gene id: 2174846:DDW44_RS11215
uniprot id: A0A2S1SSC2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

2174846:DDW44 RS11800
gene id: 2174846:DDW44_RS11800
uniprot id: A0A2S1SSK8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

2174846:DDW44 RS22925
gene id: 2174846:DDW44_RS22925
uniprot id: A0A2S1SY04
names: Similarity
messages: Belongs to the peptidase M16 family.

2174846:DDW44 RS11435
gene id: 2174846:DDW44_RS11435
uniprot id: A0A2S1SSF1
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

2174846:DDW44 RS31110
gene id: 2174846:DDW44_RS31110
uniprot id: A0A2S1T262
names: Similarity
messages: Belongs to the PrpF family.

2174846:DDW44 RS18160
gene id: 2174846:DDW44_RS18160
uniprot id: A0A2S1SVR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

2174846:DDW44 RS15970
gene id: 2174846:DDW44_RS15970
uniprot id: A0A2S1SUN1
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

2174846:DDW44 RS11380
gene id: 2174846:DDW44_RS11380
uniprot id: A0A2S1SSD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

2174846:DDW44 RS02065
gene id: 2174846:DDW44_RS02065
uniprot id: A0A2S1SMT4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

2174846:DDW44 RS17670
gene id: 2174846:DDW44_RS17670
uniprot id: A0A2S1SVG6
names: Similarity
messages: Belongs to the UPF0234 family.

2174846:DDW44 RS19575
gene id: 2174846:DDW44_RS19575
uniprot id: A0A2S1SWD2
names: Subcellular Location Annotation
messages: Cytoplasm

2174846:DDW44 RS00510
gene id: 2174846:DDW44_RS00510
uniprot id: A0A2S1SM43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

2174846:DDW44 RS02685
gene id: 2174846:DDW44_RS02685
uniprot id: A0A2S1SN73
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

2174846:DDW44 RS02455
gene id: 2174846:DDW44_RS02455
uniprot id: A0A2S1SMW3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS28845
gene id: 2174846:DDW44_RS28845
uniprot id: A0A2S1T109
names: Function
names: Similarity
messages: Belongs to the gas vesicle protein type A family.
messages: Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth.

2174846:DDW44 RS12845
gene id: 2174846:DDW44_RS12845
uniprot id: A0A2S1ST61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS27215
gene id: 2174846:DDW44_RS27215
uniprot id: A0A2S1T092
names: Cofactor
messages: Binds 1 zinc ion per subunit.

2174846:DDW44 RS22285
gene id: 2174846:DDW44_RS22285
uniprot id: A0A2S1T3E7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS01695
gene id: 2174846:DDW44_RS01695
uniprot id: A0A2S1SML1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS12335
gene id: 2174846:DDW44_RS12335
uniprot id: A0A2S1SSX8
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.

2174846:DDW44 RS18545
gene id: 2174846:DDW44_RS18545
uniprot id: A0A2S1SVY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

2174846:DDW44 RS17200
gene id: 2174846:DDW44_RS17200
uniprot id: A0A2S1SV82
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS15625
gene id: 2174846:DDW44_RS15625
uniprot id: A0A2S1SUG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

2174846:DDW44 RS28860
gene id: 2174846:DDW44_RS28860
uniprot id: A0A2S1T167
names: Function
names: Subcellular Location Annotation
messages: May play a structural or regulatory role in gas vesicle synthesis.
messages: Vesicle
messages: gas vesicle

2174846:DDW44 RS17410
gene id: 2174846:DDW44_RS17410
uniprot id: A0A2S1SVC2
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

2174846:DDW44 RS10720
gene id: 2174846:DDW44_RS10720
uniprot id: A0A2S1SS33
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS09760
gene id: 2174846:DDW44_RS09760
uniprot id: A0A2S1SRL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS29860
gene id: 2174846:DDW44_RS29860
uniprot id: A0A2S1T1K7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

2174846:DDW44 RS25420
gene id: 2174846:DDW44_RS25420
uniprot id: A0A2S1SZB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

2174846:DDW44 RS17625
gene id: 2174846:DDW44_RS17625
uniprot id: A0A2S1T337
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

2174846:DDW44 RS02265
gene id: 2174846:DDW44_RS02265
uniprot id: A0A2S1SMW5
names: Similarity
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Homohexamer. Assembles into a hexameric ring structure.

2174846:DDW44 RS24660
gene id: 2174846:DDW44_RS24660
uniprot id: A0A2S1SYV7
names: Similarity
messages: Belongs to the universal stress protein A family.

2174846:DDW44 RS02500
gene id: 2174846:DDW44_RS02500
uniprot id: A0A2S1SMZ2
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS17450
gene id: 2174846:DDW44_RS17450
uniprot id: A0A2S1SVC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2174846:DDW44 RS15255
gene id: 2174846:DDW44_RS15255
uniprot id: A0A2S1SU98
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

2174846:DDW44 RS18170
gene id: 2174846:DDW44_RS18170
uniprot id: A0A2S1SW39
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

2174846:DDW44 RS26715
gene id: 2174846:DDW44_RS26715
uniprot id: A0A2S1SZX8
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS25285
gene id: 2174846:DDW44_RS25285
uniprot id: A0A2S1SZP6
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

2174846:DDW44 RS24360
gene id: 2174846:DDW44_RS24360
uniprot id: A0A2S1SYV4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2174846:DDW44 RS10930
gene id: 2174846:DDW44_RS10930
uniprot id: A0A2S1SS52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

2174846:DDW44 RS02885
gene id: 2174846:DDW44_RS02885
uniprot id: A0A2S1SN63
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS17405
gene id: 2174846:DDW44_RS17405
uniprot id: A0A2S1SVC0
names: Subcellular Location Annotation
messages: Cytoplasm

2174846:DDW44 RS11490
gene id: 2174846:DDW44_RS11490
uniprot id: A0A2S1SSF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

2174846:DDW44 RS18885
gene id: 2174846:DDW44_RS18885
uniprot id: A0A2S1SW42
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

2174846:DDW44 RS26485
gene id: 2174846:DDW44_RS26485
uniprot id: A0A2S1SZW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS08100
gene id: 2174846:DDW44_RS08100
uniprot id: A0A2S1SQU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

2174846:DDW44 RS17490
gene id: 2174846:DDW44_RS17490
uniprot id: A0A2S1SVD7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2174846:DDW44 RS19190
gene id: 2174846:DDW44_RS19190
uniprot id: A0A2S1SWA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS15720
gene id: 2174846:DDW44_RS15720
uniprot id: A0A2S1SUI5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

2174846:DDW44 RS18100
gene id: 2174846:DDW44_RS18100
uniprot id: A0A2S1SVP4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

2174846:DDW44 RS03520
gene id: 2174846:DDW44_RS03520
uniprot id: A0A2S1SNL3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

2174846:DDW44 RS04115
gene id: 2174846:DDW44_RS04115
uniprot id: A0A2S1T2K7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 3 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

2174846:DDW44 RS22715
gene id: 2174846:DDW44_RS22715
uniprot id: A0A2S1SYG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

2174846:DDW44 RS19010
gene id: 2174846:DDW44_RS19010
uniprot id: A0A2S1SW61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.

2174846:DDW44 RS19880
gene id: 2174846:DDW44_RS19880
uniprot id: A0A2S1SWQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS10555
gene id: 2174846:DDW44_RS10555
uniprot id: A0A2S1T2T7
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

2174846:DDW44 RS10770
gene id: 2174846:DDW44_RS10770
uniprot id: A0A2S1SS29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

2174846:DDW44 RS02895
gene id: 2174846:DDW44_RS02895
uniprot id: A0A2S1SNC4
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

2174846:DDW44 RS22210
gene id: 2174846:DDW44_RS22210
uniprot id: A0A2S1SXS4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

2174846:DDW44 RS24020
gene id: 2174846:DDW44_RS24020
uniprot id: A0A2S1SYM9
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

2174846:DDW44 RS05160
gene id: 2174846:DDW44_RS05160
uniprot id: A0A2S1SPD3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

2174846:DDW44 RS20370
gene id: 2174846:DDW44_RS20370
uniprot id: A0A2S1SWT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

2174846:DDW44 RS01265
gene id: 2174846:DDW44_RS01265
uniprot id: A0A2S1SMG9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

2174846:DDW44 RS12055
gene id: 2174846:DDW44_RS12055
uniprot id: A0A2S1SSR0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS27780
gene id: 2174846:DDW44_RS27780
uniprot id: A0A2S1T0N5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

2174846:DDW44 RS04460
gene id: 2174846:DDW44_RS04460
uniprot id: A0A2S1SP47
names: Similarity
messages: Belongs to the glutamine synthetase family.

2174846:DDW44 RS05330
gene id: 2174846:DDW44_RS05330
uniprot id: A0A2S1SPF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

2174846:DDW44 RS15265
gene id: 2174846:DDW44_RS15265
uniprot id: A0A2S1SUK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

2174846:DDW44 RS06585
gene id: 2174846:DDW44_RS06585
uniprot id: A0A2S1SQ30
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. MshD subfamily.
messages: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

2174846:DDW44 RS22875
gene id: 2174846:DDW44_RS22875
uniprot id: A0A2S1SXZ5
names: Similarity
messages: Belongs to the WXG100 family.

2174846:DDW44 RS18510
gene id: 2174846:DDW44_RS18510
uniprot id: A0A2S1SVZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

2174846:DDW44 RS22140
gene id: 2174846:DDW44_RS22140
uniprot id: A0A2S1SXT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

2174846:DDW44 RS08450
gene id: 2174846:DDW44_RS08450
uniprot id: A0A2S1SR74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

2174846:DDW44 RS09765
gene id: 2174846:DDW44_RS09765
uniprot id: A0A2S1T2T2
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

2174846:DDW44 RS16730
gene id: 2174846:DDW44_RS16730
uniprot id: A0A2S1SV06
names: Similarity
messages: Belongs to the UPF0145 family.

2174846:DDW44 RS13570
gene id: 2174846:DDW44_RS13570
uniprot id: A0A2S1STH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

2174846:DDW44 RS17665
gene id: 2174846:DDW44_RS17665
uniprot id: A0A2S1SVH2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

2174846:DDW44 RS12820
gene id: 2174846:DDW44_RS12820
uniprot id: A0A2S1STC2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

2174846:DDW44 RS11460
gene id: 2174846:DDW44_RS11460
uniprot id: A0A2S1SSF0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS27035
gene id: 2174846:DDW44_RS27035
uniprot id: A0A2S1T073
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SsgA family.
messages: Cell septum

2174846:DDW44 RS28825
gene id: 2174846:DDW44_RS28825
uniprot id: A0A2S1T112
names: Function
names: Subcellular Location Annotation
messages: May play a structural or regulatory role in gas vesicle synthesis.
messages: Vesicle
messages: gas vesicle

2174846:DDW44 RS15095
gene id: 2174846:DDW44_RS15095
uniprot id: A0A2S1SUI1
names: Similarity
messages: Belongs to the 6-phosphogluconate dehydrogenase family.

2174846:DDW44 RS18875
gene id: 2174846:DDW44_RS18875
uniprot id: A0A2S1SW20
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS12425
gene id: 2174846:DDW44_RS12425
uniprot id: A0A2S1SSY8
names: Similarity
messages: Belongs to the UDPGP type 2 family.

2174846:DDW44 RS05655
gene id: 2174846:DDW44_RS05655
uniprot id: A0A2S1SPL5
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

2174846:DDW44 RS14980
gene id: 2174846:DDW44_RS14980
uniprot id: A0A2S1SU75
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

2174846:DDW44 RS22065
gene id: 2174846:DDW44_RS22065
uniprot id: A0A2S1SY56
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

2174846:DDW44 RS05430
gene id: 2174846:DDW44_RS05430
uniprot id: A0A2S1T2P3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS08260
gene id: 2174846:DDW44_RS08260
uniprot id: A0A2S1SQU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

2174846:DDW44 RS16780
gene id: 2174846:DDW44_RS16780
uniprot id: A0A2S1SV16
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

2174846:DDW44 RS11575
gene id: 2174846:DDW44_RS11575
uniprot id: A0A2S1SSI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

2174846:DDW44 RS26330
gene id: 2174846:DDW44_RS26330
uniprot id: A0A2S1SZS7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

2174846:DDW44 RS06180
gene id: 2174846:DDW44_RS06180
uniprot id: A0A2S1SPU3
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

2174846:DDW44 RS27235
gene id: 2174846:DDW44_RS27235
uniprot id: A0A2S1T080
names: Similarity
messages: Belongs to the ABC transporter superfamily.

2174846:DDW44 RS22435
gene id: 2174846:DDW44_RS22435
uniprot id: A0A2S1SXS6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

2174846:DDW44 RS01935
gene id: 2174846:DDW44_RS01935
uniprot id: A0A2S1SMS7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS19325
gene id: 2174846:DDW44_RS19325
uniprot id: A0A2S1SWA5
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS17455
gene id: 2174846:DDW44_RS17455
uniprot id: A0A2S1SVD1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2174846:DDW44 RS01370
gene id: 2174846:DDW44_RS01370
uniprot id: A0A2S1SMI9
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

2174846:DDW44 RS24435
gene id: 2174846:DDW44_RS24435
uniprot id: A0A2S1SYW1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

2174846:DDW44 RS11175
gene id: 2174846:DDW44_RS11175
uniprot id: A0A2S1SS96
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

2174846:DDW44 RS25560
gene id: 2174846:DDW44_RS25560
uniprot id: A0A2S1SZE6
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS17325
gene id: 2174846:DDW44_RS17325
uniprot id: A0A2S1SVA6
names: Similarity
messages: Belongs to the AHA1 family.

2174846:DDW44 RS04275
gene id: 2174846:DDW44_RS04275
uniprot id: A0A2S1SNX7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

2174846:DDW44 RS25930
gene id: 2174846:DDW44_RS25930
uniprot id: A0A2S1SZL3
names: Similarity
messages: Belongs to the malate synthase family.

2174846:DDW44 RS16740
gene id: 2174846:DDW44_RS16740
uniprot id: A0A2S1SV01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

2174846:DDW44 RS06615
gene id: 2174846:DDW44_RS06615
uniprot id: A0A2S1SQ84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

2174846:DDW44 RS17995
gene id: 2174846:DDW44_RS17995
uniprot id: A0A2S1T336
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

2174846:DDW44 RS10630
gene id: 2174846:DDW44_RS10630
uniprot id: A0A2S1SS50
names: Similarity
messages: Belongs to the IMPACT family.

2174846:DDW44 RS29185
gene id: 2174846:DDW44_RS29185
uniprot id: A0A2S1T190
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

2174846:DDW44 RS20425
gene id: 2174846:DDW44_RS20425
uniprot id: A0A2S1SWU5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

2174846:DDW44 RS06635
gene id: 2174846:DDW44_RS06635
uniprot id: A0A2S1SQ40
names: Similarity
messages: Belongs to the PhoU family.
messages: Belongs to the UPF0111 family.

2174846:DDW44 RS21925
gene id: 2174846:DDW44_RS21925
uniprot id: A0A2S1SXM8
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

2174846:DDW44 RS02935
gene id: 2174846:DDW44_RS02935
uniprot id: A0A2S1SN74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

2174846:DDW44 RS17460
gene id: 2174846:DDW44_RS17460
uniprot id: A0A2S1SVD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2174846:DDW44 RS02715
gene id: 2174846:DDW44_RS02715
uniprot id: A0A2S1SN88
names: Function
names: Similarity
messages: Belongs to the ectoine synthase family.
messages: Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.

2174846:DDW44 RS02870
gene id: 2174846:DDW44_RS02870
uniprot id: A0A2S1SN76
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

2174846:DDW44 RS11530
gene id: 2174846:DDW44_RS11530
uniprot id: A0A2S1SSI5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

2174846:DDW44 RS08555
gene id: 2174846:DDW44_RS08555
uniprot id: A0A2S1SR94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

2174846:DDW44 RS08995
gene id: 2174846:DDW44_RS08995
uniprot id: A0A2S1SR93
names: Similarity
messages: Belongs to the group II decarboxylase family.

2174846:DDW44 RS02125
gene id: 2174846:DDW44_RS02125
uniprot id: A0A2S1SMU6
names: Subcellular Location Annotation
messages: Membrane

2174846:DDW44 RS29855
gene id: 2174846:DDW44_RS29855
uniprot id: A0A2S1T1P5
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

2174846:DDW44 RS23880
gene id: 2174846:DDW44_RS23880
uniprot id: A0A2S1SYL3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2174846:DDW44 RS17585
gene id: 2174846:DDW44_RS17585
uniprot id: A0A2S1SVT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2174846:DDW44 RS04500
gene id: 2174846:DDW44_RS04500
uniprot id: A0A2S1SP17
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS15070
gene id: 2174846:DDW44_RS15070
uniprot id: A0A2S1SU70
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

2174846:DDW44 RS29205
gene id: 2174846:DDW44_RS29205
uniprot id: A0A2S1T174
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2174846:DDW44 RS24695
gene id: 2174846:DDW44_RS24695
uniprot id: A0A2S1SZ15
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

2174846:DDW44 RS05215
gene id: 2174846:DDW44_RS05215
uniprot id: A0A2S1SPE8
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

2174846:DDW44 RS13285
gene id: 2174846:DDW44_RS13285
uniprot id: A0A2S1STC9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.