216432:CA2559 RS10360
gene id: 216432:CA2559_RS10360
uniprot id: A3U9G6
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

216432:CA2559 RS01675
gene id: 216432:CA2559_RS01675
uniprot id: A3U5A3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS02740
gene id: 216432:CA2559_RS02740
uniprot id: A3U5W7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

216432:CA2559 RS00720
gene id: 216432:CA2559_RS00720
uniprot id: A3U4R6
names: Similarity
messages: Belongs to the arginase family.

216432:CA2559 RS06785
gene id: 216432:CA2559_RS06785
uniprot id: A3U878
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

216432:CA2559 RS10740
gene id: 216432:CA2559_RS10740
uniprot id: A3U9P5
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

216432:CA2559 RS01760
gene id: 216432:CA2559_RS01760
uniprot id: A3U5C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

216432:CA2559 RS03055
gene id: 216432:CA2559_RS03055
uniprot id: A3U630
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

216432:CA2559 RS04865
gene id: 216432:CA2559_RS04865
uniprot id: A3U741
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

216432:CA2559 RS09895
gene id: 216432:CA2559_RS09895
uniprot id: A3U970
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

216432:CA2559 RS09875
gene id: 216432:CA2559_RS09875
uniprot id: A3U965
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

216432:CA2559 RS01550
gene id: 216432:CA2559_RS01550
uniprot id: A3U578
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

216432:CA2559 RS10235
gene id: 216432:CA2559_RS10235
uniprot id: A3U9E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

216432:CA2559 RS12655
gene id: 216432:CA2559_RS12655
uniprot id: A3UAT7
names: Similarity
messages: Belongs to the CarB family.

216432:CA2559 RS01970
gene id: 216432:CA2559_RS01970
uniprot id: A3U5G2
names: Similarity
messages: Belongs to the SusD family.

216432:CA2559 RS04010
gene id: 216432:CA2559_RS04010
uniprot id: A3U6M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

216432:CA2559 RS01815
gene id: 216432:CA2559_RS01815
uniprot id: A3U5D1
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS08525
gene id: 216432:CA2559_RS08525
uniprot id: A3UBT1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

216432:CA2559 RS00120
gene id: 216432:CA2559_RS00120
uniprot id: A3U4E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

216432:CA2559 RS07175
gene id: 216432:CA2559_RS07175
uniprot id: A3U8G0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

216432:CA2559 RS01235
gene id: 216432:CA2559_RS01235
uniprot id: A3U515
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

216432:CA2559 RS07160
gene id: 216432:CA2559_RS07160
uniprot id: A3U8F7
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

216432:CA2559 RS03185
gene id: 216432:CA2559_RS03185
uniprot id: A3U657
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

216432:CA2559 RS02405
gene id: 216432:CA2559_RS02405
uniprot id: A3U5Q0
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS12890
gene id: 216432:CA2559_RS12890
uniprot id: A3UAY6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

216432:CA2559 RS05855
gene id: 216432:CA2559_RS05855
uniprot id: A3U7N9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

216432:CA2559 RS11835
gene id: 216432:CA2559_RS11835
uniprot id: A3UAC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

216432:CA2559 RS01680
gene id: 216432:CA2559_RS01680
uniprot id: A3U5A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

216432:CA2559 RS01880
gene id: 216432:CA2559_RS01880
uniprot id: A3U5E4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

216432:CA2559 RS13330
gene id: 216432:CA2559_RS13330
uniprot id: A3UB75
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

216432:CA2559 RS02240
gene id: 216432:CA2559_RS02240
uniprot id: A3U5L6
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

216432:CA2559 RS12925
gene id: 216432:CA2559_RS12925
uniprot id: A3UAZ3
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

216432:CA2559 RS12260
gene id: 216432:CA2559_RS12260
uniprot id: A3UAK8
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS03305
gene id: 216432:CA2559_RS03305
uniprot id: A3U681
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS05250
gene id: 216432:CA2559_RS05250
uniprot id: A3U7B5
names: Similarity
messages: Belongs to the DEAD box helicase family.

216432:CA2559 RS09750
gene id: 216432:CA2559_RS09750
uniprot id: A3U940
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

216432:CA2559 RS11595
gene id: 216432:CA2559_RS11595
uniprot id: A3UA73
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

216432:CA2559 RS05105
gene id: 216432:CA2559_RS05105
uniprot id: A3U787
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS02540
gene id: 216432:CA2559_RS02540
uniprot id: A3U5S7
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

216432:CA2559 RS03450
gene id: 216432:CA2559_RS03450
uniprot id: A3U6A9
names: Similarity
messages: Belongs to the LacAB/RpiB family.

216432:CA2559 RS05820
gene id: 216432:CA2559_RS05820
uniprot id: A3U7N1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

216432:CA2559 RS09240
gene id: 216432:CA2559_RS09240
uniprot id: A3U8U3
names: Similarity
messages: Belongs to the DEAD box helicase family.

216432:CA2559 RS10070
gene id: 216432:CA2559_RS10070
uniprot id: A3U9A8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

216432:CA2559 RS10160
gene id: 216432:CA2559_RS10160
uniprot id: A3U9C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

216432:CA2559 RS08365
gene id: 216432:CA2559_RS08365
uniprot id: A3UBP9
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

216432:CA2559 RS08880
gene id: 216432:CA2559_RS08880
uniprot id: A3UC04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

216432:CA2559 RS05880
gene id: 216432:CA2559_RS05880
uniprot id: A3U7P4
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

216432:CA2559 RS00495
gene id: 216432:CA2559_RS00495
uniprot id: A3U4M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

216432:CA2559 RS12905
gene id: 216432:CA2559_RS12905
uniprot id: A3UAY9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

216432:CA2559 RS04195
gene id: 216432:CA2559_RS04195
uniprot id: A3U6Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

216432:CA2559 RS02490
gene id: 216432:CA2559_RS02490
uniprot id: A3U5R7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

216432:CA2559 RS13345
gene id: 216432:CA2559_RS13345
uniprot id: A3UB78
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

216432:CA2559 RS00150
gene id: 216432:CA2559_RS00150
uniprot id: A3U4E7
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS12545
gene id: 216432:CA2559_RS12545
uniprot id: A3UAR5
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

216432:CA2559 RS01585
gene id: 216432:CA2559_RS01585
uniprot id: A3U585
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

216432:CA2559 RS09310
gene id: 216432:CA2559_RS09310
uniprot id: A3U8V7
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

216432:CA2559 RS12605
gene id: 216432:CA2559_RS12605
uniprot id: A3UAS7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS08105
gene id: 216432:CA2559_RS08105
uniprot id: A3UBJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

216432:CA2559 RS10735
gene id: 216432:CA2559_RS10735
uniprot id: A3U9P4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

216432:CA2559 RS01120
gene id: 216432:CA2559_RS01120
uniprot id: A3U4Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

216432:CA2559 RS04360
gene id: 216432:CA2559_RS04360
uniprot id: A3U6U0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS05185
gene id: 216432:CA2559_RS05185
uniprot id: A3U7A3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

216432:CA2559 RS01575
gene id: 216432:CA2559_RS01575
uniprot id: A3U583
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

216432:CA2559 RS01860
gene id: 216432:CA2559_RS01860
uniprot id: A3U5E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

216432:CA2559 RS13295
gene id: 216432:CA2559_RS13295
uniprot id: A3UB68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

216432:CA2559 RS02680
gene id: 216432:CA2559_RS02680
uniprot id: A3U5V5
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

216432:CA2559 RS04565
gene id: 216432:CA2559_RS04565
uniprot id: A3U6Y1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

216432:CA2559 RS12960
gene id: 216432:CA2559_RS12960
uniprot id: A3UB00
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

216432:CA2559 RS05900
gene id: 216432:CA2559_RS05900
uniprot id: A3U7P8
names: Similarity
messages: Belongs to the citrate synthase family.

216432:CA2559 RS11220
gene id: 216432:CA2559_RS11220
uniprot id: A3U9Z4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

216432:CA2559 RS07380
gene id: 216432:CA2559_RS07380
uniprot id: A3U8K1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

216432:CA2559 RS09105
gene id: 216432:CA2559_RS09105
uniprot id: A3U8R5
names: Similarity
messages: Belongs to the ArsC family.

216432:CA2559 RS00955
gene id: 216432:CA2559_RS00955
uniprot id: A3U4W1
names: Subcellular Location Annotation
messages: Mitochondrion

216432:CA2559 RS02420
gene id: 216432:CA2559_RS02420
uniprot id: A3U5Q3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

216432:CA2559 RS03815
gene id: 216432:CA2559_RS03815
uniprot id: A3U6I2
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS11740
gene id: 216432:CA2559_RS11740
uniprot id: A3UAA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

216432:CA2559 RS09685
gene id: 216432:CA2559_RS09685
uniprot id: A3U927
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

216432:CA2559 RS03365
gene id: 216432:CA2559_RS03365
uniprot id: A3U693
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

216432:CA2559 RS01135
gene id: 216432:CA2559_RS01135
uniprot id: A3U4Z5
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

216432:CA2559 RS13110
gene id: 216432:CA2559_RS13110
uniprot id: A3UB31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

216432:CA2559 RS12350
gene id: 216432:CA2559_RS12350
uniprot id: A3UAM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

216432:CA2559 RS08235
gene id: 216432:CA2559_RS08235
uniprot id: A3UBM3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

216432:CA2559 RS08640
gene id: 216432:CA2559_RS08640
uniprot id: A3UBV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

216432:CA2559 RS04555
gene id: 216432:CA2559_RS04555
uniprot id: A3U6X9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Required for cell division and gliding motility.

216432:CA2559 RS07375
gene id: 216432:CA2559_RS07375
uniprot id: A3U8K0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

216432:CA2559 RS12950
gene id: 216432:CA2559_RS12950
uniprot id: A3UAZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

216432:CA2559 RS10195
gene id: 216432:CA2559_RS10195
uniprot id: A3U9D3
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS02100
gene id: 216432:CA2559_RS02100
uniprot id: A3U5I8
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

216432:CA2559 RS03720
gene id: 216432:CA2559_RS03720
uniprot id: A3U6G3
names: Cofactor
names: Similarity
messages: Belongs to the fatty acid desaturase type 2 family.
messages: Binds 2 iron ions per subunit.

216432:CA2559 RS02840
gene id: 216432:CA2559_RS02840
uniprot id: A3U5Y7
names: Similarity
messages: Belongs to the RecJ family.

216432:CA2559 RS04660
gene id: 216432:CA2559_RS04660
uniprot id: A3U700
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

216432:CA2559 RS04090
gene id: 216432:CA2559_RS04090
uniprot id: A3U6N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

216432:CA2559 RS05840
gene id: 216432:CA2559_RS05840
uniprot id: A3U7N5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

216432:CA2559 RS10535
gene id: 216432:CA2559_RS10535
uniprot id: A3U9K1
names: Subcellular Location Annotation
messages: Secreted

216432:CA2559 RS03120
gene id: 216432:CA2559_RS03120
uniprot id: A3U643
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

216432:CA2559 RS04330
gene id: 216432:CA2559_RS04330
uniprot id: A3U6T4
names: Similarity
messages: Belongs to the Skp family.

216432:CA2559 RS05675
gene id: 216432:CA2559_RS05675
uniprot id: A3U7K0
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

216432:CA2559 RS09145
gene id: 216432:CA2559_RS09145
uniprot id: A3U8S3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

216432:CA2559 RS10430
gene id: 216432:CA2559_RS10430
uniprot id: A3U9I0
names: Similarity
messages: Belongs to the peptidase C1 family.

216432:CA2559 RS01075
gene id: 216432:CA2559_RS01075
uniprot id: A3U4Y3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

216432:CA2559 RS06625
gene id: 216432:CA2559_RS06625
uniprot id: A3U846
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

216432:CA2559 RS05340
gene id: 216432:CA2559_RS05340
uniprot id: A3U7D4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

216432:CA2559 RS06225
gene id: 216432:CA2559_RS06225
uniprot id: A3U7W4
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

216432:CA2559 RS00240
gene id: 216432:CA2559_RS00240
uniprot id: A3U4G6
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS12920
gene id: 216432:CA2559_RS12920
uniprot id: A3UAZ2
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

216432:CA2559 RS04015
gene id: 216432:CA2559_RS04015
uniprot id: A3U6M2
names: Similarity
messages: Belongs to the peptidase S41A family.

216432:CA2559 RS08330
gene id: 216432:CA2559_RS08330
uniprot id: A3UBP2
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

216432:CA2559 RS07865
gene id: 216432:CA2559_RS07865
uniprot id: A3UBE8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS06460
gene id: 216432:CA2559_RS06460
uniprot id: A3U812
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

216432:CA2559 RS03535
gene id: 216432:CA2559_RS03535
uniprot id: A3U6C7
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

216432:CA2559 RS04535
gene id: 216432:CA2559_RS04535
uniprot id: A3U6X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

216432:CA2559 RS07060
gene id: 216432:CA2559_RS07060
uniprot id: A3U8D6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

216432:CA2559 RS00845
gene id: 216432:CA2559_RS00845
uniprot id: A3U4U1
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

216432:CA2559 RS06960
gene id: 216432:CA2559_RS06960
uniprot id: A3U8B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

216432:CA2559 RS01425
gene id: 216432:CA2559_RS01425
uniprot id: A3U553
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

216432:CA2559 RS06520
gene id: 216432:CA2559_RS06520
uniprot id: A3U825
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

216432:CA2559 RS08905
gene id: 216432:CA2559_RS08905
uniprot id: A3UC09
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

216432:CA2559 RS06950
gene id: 216432:CA2559_RS06950
uniprot id: A3U8B4
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS07760
gene id: 216432:CA2559_RS07760
uniprot id: A3UBC7
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

216432:CA2559 RS10005
gene id: 216432:CA2559_RS10005
uniprot id: A3U994
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

216432:CA2559 RS04220
gene id: 216432:CA2559_RS04220
uniprot id: A3U6R2
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS06060
gene id: 216432:CA2559_RS06060
uniprot id: A3U7T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

216432:CA2559 RS05155
gene id: 216432:CA2559_RS05155
uniprot id: A3U797
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

216432:CA2559 RS00750
gene id: 216432:CA2559_RS00750
uniprot id: A3U4S2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS08780
gene id: 216432:CA2559_RS08780
uniprot id: A3UBY2
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

216432:CA2559 RS08085
gene id: 216432:CA2559_RS08085
uniprot id: A3UBJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

216432:CA2559 RS12310
gene id: 216432:CA2559_RS12310
uniprot id: A3UAL8
names: Similarity
messages: Belongs to the peptidase S33 family.

216432:CA2559 RS05930
gene id: 216432:CA2559_RS05930
uniprot id: A3U7Q4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

216432:CA2559 RS09615
gene id: 216432:CA2559_RS09615
uniprot id: A3U918
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

216432:CA2559 RS04975
gene id: 216432:CA2559_RS04975
uniprot id: A3U762
names: Similarity
messages: Belongs to the thioredoxin family.

216432:CA2559 RS12995
gene id: 216432:CA2559_RS12995
uniprot id: A3UB07
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

216432:CA2559 RS06540
gene id: 216432:CA2559_RS06540
uniprot id: A3U829
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

216432:CA2559 RS09885
gene id: 216432:CA2559_RS09885
uniprot id: A3U968
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

216432:CA2559 RS01920
gene id: 216432:CA2559_RS01920
uniprot id: A3U5F2
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

216432:CA2559 RS13375
gene id: 216432:CA2559_RS13375
uniprot id: A3UB85
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

216432:CA2559 RS05740
gene id: 216432:CA2559_RS05740
uniprot id: A3U7L4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

216432:CA2559 RS07575
gene id: 216432:CA2559_RS07575
uniprot id: A3U8P0
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

216432:CA2559 RS02795
gene id: 216432:CA2559_RS02795
uniprot id: A3U5X8
names: Similarity
messages: Belongs to the asparaginase 1 family.

216432:CA2559 RS09965
gene id: 216432:CA2559_RS09965
uniprot id: A3U984
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

216432:CA2559 RS02590
gene id: 216432:CA2559_RS02590
uniprot id: A3U5T7
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

216432:CA2559 RS05325
gene id: 216432:CA2559_RS05325
uniprot id: A3U7D0
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS08595
gene id: 216432:CA2559_RS08595
uniprot id: A3UBU5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

216432:CA2559 RS06240
gene id: 216432:CA2559_RS06240
uniprot id: A3U7W7
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

216432:CA2559 RS07660
gene id: 216432:CA2559_RS07660
uniprot id: A3UBA5
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

216432:CA2559 RS05645
gene id: 216432:CA2559_RS05645
uniprot id: A3U7J3
names: Similarity
messages: Belongs to the UPF0758 family.

216432:CA2559 RS01355
gene id: 216432:CA2559_RS01355
uniprot id: A3U540
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

216432:CA2559 RS05115
gene id: 216432:CA2559_RS05115
uniprot id: A3U789
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

216432:CA2559 RS00555
gene id: 216432:CA2559_RS00555
uniprot id: A3U4N3
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS09790
gene id: 216432:CA2559_RS09790
uniprot id: A3U948
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS04485
gene id: 216432:CA2559_RS04485
uniprot id: A3U6W5
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

216432:CA2559 RS12415
gene id: 216432:CA2559_RS12415
uniprot id: A3UAN8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS06285
gene id: 216432:CA2559_RS06285
uniprot id: A3U7X6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

216432:CA2559 RS08600
gene id: 216432:CA2559_RS08600
uniprot id: A3UBU6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS06280
gene id: 216432:CA2559_RS06280
uniprot id: A3U7X5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the N-terminal section; belongs to the DHBP synthase family.

216432:CA2559 RS03065
gene id: 216432:CA2559_RS03065
uniprot id: A3U632
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

216432:CA2559 RS09000
gene id: 216432:CA2559_RS09000
uniprot id: A3UC28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

216432:CA2559 RS03300
gene id: 216432:CA2559_RS03300
uniprot id: A3U680
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

216432:CA2559 RS10730
gene id: 216432:CA2559_RS10730
uniprot id: A3U9P3
names: Function
names: Similarity
messages: Belongs to the TenA family.
messages: Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.

216432:CA2559 RS02665
gene id: 216432:CA2559_RS02665
uniprot id: A3U5V2
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

216432:CA2559 RS13370
gene id: 216432:CA2559_RS13370
uniprot id: A3UB84
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

216432:CA2559 RS05615
gene id: 216432:CA2559_RS05615
uniprot id: A3U7I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

216432:CA2559 RS11140
gene id: 216432:CA2559_RS11140
uniprot id: A3U9X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell inner membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

216432:CA2559 RS07410
gene id: 216432:CA2559_RS07410
uniprot id: A3U8K7
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

216432:CA2559 RS11630
gene id: 216432:CA2559_RS11630
uniprot id: A3UA81
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS01170
gene id: 216432:CA2559_RS01170
uniprot id: A3U502
names: Similarity
messages: Belongs to the SCO1/2 family.

216432:CA2559 RS07870
gene id: 216432:CA2559_RS07870
uniprot id: A3UBE9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

216432:CA2559 RS07100
gene id: 216432:CA2559_RS07100
uniprot id: A3U8E4
names: Similarity
messages: Belongs to the ParB family.

216432:CA2559 RS04665
gene id: 216432:CA2559_RS04665
uniprot id: A3U701
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

216432:CA2559 RS06230
gene id: 216432:CA2559_RS06230
uniprot id: A3U7W5
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

216432:CA2559 RS08910
gene id: 216432:CA2559_RS08910
uniprot id: A3UC10
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

216432:CA2559 RS12680
gene id: 216432:CA2559_RS12680
uniprot id: A3UAU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell inner membrane
messages: Membrane

216432:CA2559 RS09625
gene id: 216432:CA2559_RS09625
uniprot id: A3U920
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

216432:CA2559 RS09505
gene id: 216432:CA2559_RS09505
uniprot id: A3U8Z7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

216432:CA2559 RS08730
gene id: 216432:CA2559_RS08730
uniprot id: A3UBX2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

216432:CA2559 RS12125
gene id: 216432:CA2559_RS12125
uniprot id: A3UAI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

216432:CA2559 RS01305
gene id: 216432:CA2559_RS01305
uniprot id: A3U529
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

216432:CA2559 RS01145
gene id: 216432:CA2559_RS01145
uniprot id: A3U4Z7
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS02630
gene id: 216432:CA2559_RS02630
uniprot id: A3U5U5
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS02325
gene id: 216432:CA2559_RS02325
uniprot id: A3U5N4
names: Similarity
messages: Belongs to the aspartokinase family.

216432:CA2559 RS04775
gene id: 216432:CA2559_RS04775
uniprot id: A3U723
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

216432:CA2559 RS01025
gene id: 216432:CA2559_RS01025
uniprot id: A3U4X5
names: Similarity
messages: Belongs to the BshC family.

216432:CA2559 RS07030
gene id: 216432:CA2559_RS07030
uniprot id: A3U8D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

216432:CA2559 RS08725
gene id: 216432:CA2559_RS08725
uniprot id: A3UBX1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

216432:CA2559 RS07910
gene id: 216432:CA2559_RS07910
uniprot id: A3UBF7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

216432:CA2559 RS11540
gene id: 216432:CA2559_RS11540
uniprot id: A3UA61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

216432:CA2559 RS11590
gene id: 216432:CA2559_RS11590
uniprot id: A3UA72
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS09500
gene id: 216432:CA2559_RS09500
uniprot id: A3U8Z6
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

216432:CA2559 RS00700
gene id: 216432:CA2559_RS00700
uniprot id: A3U4R2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

216432:CA2559 RS05805
gene id: 216432:CA2559_RS05805
uniprot id: A3U7M8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

216432:CA2559 RS01455
gene id: 216432:CA2559_RS01455
uniprot id: A3U559
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

216432:CA2559 RS07350
gene id: 216432:CA2559_RS07350
uniprot id: A3U8J5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

216432:CA2559 RS13355
gene id: 216432:CA2559_RS13355
uniprot id: A3UB80
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

216432:CA2559 RS13300
gene id: 216432:CA2559_RS13300
uniprot id: A3UB69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

216432:CA2559 RS09940
gene id: 216432:CA2559_RS09940
uniprot id: A3U979
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

216432:CA2559 RS02770
gene id: 216432:CA2559_RS02770
uniprot id: A3U5X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

216432:CA2559 RS13270
gene id: 216432:CA2559_RS13270
uniprot id: A3UB64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

216432:CA2559 RS03420
gene id: 216432:CA2559_RS03420
uniprot id: A3U6A4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

216432:CA2559 RS06265
gene id: 216432:CA2559_RS06265
uniprot id: A3U7X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

216432:CA2559 RS06290
gene id: 216432:CA2559_RS06290
uniprot id: A3U7X7
names: Similarity
messages: Belongs to the nitroreductase family.

216432:CA2559 RS02745
gene id: 216432:CA2559_RS02745
uniprot id: A3U5W8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

216432:CA2559 RS01185
gene id: 216432:CA2559_RS01185
uniprot id: A3U505
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Membrane

216432:CA2559 RS08075
gene id: 216432:CA2559_RS08075
uniprot id: A3UBJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxC family.
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

216432:CA2559 RS10290
gene id: 216432:CA2559_RS10290
uniprot id: A3U9F2
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

216432:CA2559 RS12265
gene id: 216432:CA2559_RS12265
uniprot id: A3UAK9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

216432:CA2559 RS10980
gene id: 216432:CA2559_RS10980
uniprot id: A3U9U4
names: Similarity
messages: Belongs to the CvfB family.

216432:CA2559 RS09785
gene id: 216432:CA2559_RS09785
uniprot id: A3U947
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

216432:CA2559 RS03940
gene id: 216432:CA2559_RS03940
uniprot id: A3U6K7
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

216432:CA2559 RS13000
gene id: 216432:CA2559_RS13000
uniprot id: A3UB08
names: Similarity
messages: Belongs to the Dps family.

216432:CA2559 RS03195
gene id: 216432:CA2559_RS03195
uniprot id: A3U659
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS10130
gene id: 216432:CA2559_RS10130
uniprot id: A3U9C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Membrane

216432:CA2559 RS09300
gene id: 216432:CA2559_RS09300
uniprot id: A3U8V5
names: Similarity
messages: Belongs to the LOG family.

216432:CA2559 RS02105
gene id: 216432:CA2559_RS02105
uniprot id: A3U5I9
names: Similarity
messages: Belongs to the UPF0102 family.

216432:CA2559 RS01640
gene id: 216432:CA2559_RS01640
uniprot id: A3U596
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

216432:CA2559 RS10270
gene id: 216432:CA2559_RS10270
uniprot id: A3U9E8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

216432:CA2559 RS05955
gene id: 216432:CA2559_RS05955
uniprot id: A3U7Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

216432:CA2559 RS08055
gene id: 216432:CA2559_RS08055
uniprot id: A3UBI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

216432:CA2559 RS11520
gene id: 216432:CA2559_RS11520
uniprot id: A3UA57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MerT family.
messages: Cell inner membrane
messages: Membrane

216432:CA2559 RS03500
gene id: 216432:CA2559_RS03500
uniprot id: A3U6C0
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

216432:CA2559 RS07905
gene id: 216432:CA2559_RS07905
uniprot id: A3UBF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

216432:CA2559 RS10310
gene id: 216432:CA2559_RS10310
uniprot id: A3U9F6
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS05490
gene id: 216432:CA2559_RS05490
uniprot id: A3U7G4
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

216432:CA2559 RS06820
gene id: 216432:CA2559_RS06820
uniprot id: A3U885
names: Similarity
messages: Belongs to the asparagine synthetase family.

216432:CA2559 RS01240
gene id: 216432:CA2559_RS01240
uniprot id: A3U516
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

216432:CA2559 RS11515
gene id: 216432:CA2559_RS11515
uniprot id: A3UA56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

216432:CA2559 RS08305
gene id: 216432:CA2559_RS08305
uniprot id: A3UBN7
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

216432:CA2559 RS02485
gene id: 216432:CA2559_RS02485
uniprot id: A3U5R6
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

216432:CA2559 RS03125
gene id: 216432:CA2559_RS03125
uniprot id: A3U644
names: Similarity
messages: Belongs to the peptidase S41A family.

216432:CA2559 RS05885
gene id: 216432:CA2559_RS05885
uniprot id: A3U7P5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

216432:CA2559 RS04815
gene id: 216432:CA2559_RS04815
uniprot id: A3U731
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

216432:CA2559 RS10970
gene id: 216432:CA2559_RS10970
uniprot id: A3U9U2
names: Similarity
messages: Belongs to the RutC family.

216432:CA2559 RS05780
gene id: 216432:CA2559_RS05780
uniprot id: A3U7M2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

216432:CA2559 RS11350
gene id: 216432:CA2559_RS11350
uniprot id: A3UA21
names: Similarity
messages: Belongs to the SusD family.

216432:CA2559 RS12220
gene id: 216432:CA2559_RS12220
uniprot id: A3UAK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

216432:CA2559 RS02890
gene id: 216432:CA2559_RS02890
uniprot id: A3U5Z8
names: Similarity
messages: Belongs to the universal stress protein A family.

216432:CA2559 RS13420
gene id: 216432:CA2559_RS13420
uniprot id: A3UB94
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

216432:CA2559 RS10645
gene id: 216432:CA2559_RS10645
uniprot id: A3U9M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

216432:CA2559 RS10010
gene id: 216432:CA2559_RS10010
uniprot id: A3U995
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS03680
gene id: 216432:CA2559_RS03680
uniprot id: A3U6F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

216432:CA2559 RS07610
gene id: 216432:CA2559_RS07610
uniprot id: A3U8P7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

216432:CA2559 RS00560
gene id: 216432:CA2559_RS00560
uniprot id: A3U4N4
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

216432:CA2559 RS06120
gene id: 216432:CA2559_RS06120
uniprot id: A3U7U3
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS04935
gene id: 216432:CA2559_RS04935
uniprot id: A3U755
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

216432:CA2559 RS02605
gene id: 216432:CA2559_RS02605
uniprot id: A3U5U0
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

216432:CA2559 RS10545
gene id: 216432:CA2559_RS10545
uniprot id: A3U9K4
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

216432:CA2559 RS06805
gene id: 216432:CA2559_RS06805
uniprot id: A3U882
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS06865
gene id: 216432:CA2559_RS06865
uniprot id: A3U896
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IcmF family.
messages: Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
messages: Homodimer.
messages: Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS02045
gene id: 216432:CA2559_RS02045
uniprot id: A3U5H7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

216432:CA2559 RS10140
gene id: 216432:CA2559_RS10140
uniprot id: A3U9C2
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

216432:CA2559 RS08990
gene id: 216432:CA2559_RS08990
uniprot id: A3UC26
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

216432:CA2559 RS12485
gene id: 216432:CA2559_RS12485
uniprot id: A3UAQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

216432:CA2559 RS02400
gene id: 216432:CA2559_RS02400
uniprot id: A3U5P9
names: Similarity
messages: Belongs to the peptidase S9A family.

216432:CA2559 RS03690
gene id: 216432:CA2559_RS03690
uniprot id: A3U6F7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

216432:CA2559 RS10165
gene id: 216432:CA2559_RS10165
uniprot id: A3U9C7
names: Similarity
messages: Belongs to the AlaDH/PNT family.

216432:CA2559 RS08560
gene id: 216432:CA2559_RS08560
uniprot id: A3UBT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

216432:CA2559 RS12355
gene id: 216432:CA2559_RS12355
uniprot id: A3UAM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

216432:CA2559 RS05405
gene id: 216432:CA2559_RS05405
uniprot id: A3U7E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

216432:CA2559 RS04480
gene id: 216432:CA2559_RS04480
uniprot id: A3U6W4
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

216432:CA2559 RS09985
gene id: 216432:CA2559_RS09985
uniprot id: A3U989
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

216432:CA2559 RS09425
gene id: 216432:CA2559_RS09425
uniprot id: A3U8Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

216432:CA2559 RS12385
gene id: 216432:CA2559_RS12385
uniprot id: A3UAN2
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS11170
gene id: 216432:CA2559_RS11170
uniprot id: A3U9Y3
names: Similarity
messages: Belongs to the DNA photolyase family.

216432:CA2559 RS09390
gene id: 216432:CA2559_RS09390
uniprot id: A3U8X3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

216432:CA2559 RS09340
gene id: 216432:CA2559_RS09340
uniprot id: A3U8W3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS08545
gene id: 216432:CA2559_RS08545
uniprot id: A3UBT5
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

216432:CA2559 RS03370
gene id: 216432:CA2559_RS03370
uniprot id: A3U694
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

216432:CA2559 RS08760
gene id: 216432:CA2559_RS08760
uniprot id: A3UBX8
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS09295
gene id: 216432:CA2559_RS09295
uniprot id: A3U8V4
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

216432:CA2559 RS02220
gene id: 216432:CA2559_RS02220
uniprot id: A3U5L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

216432:CA2559 RS06715
gene id: 216432:CA2559_RS06715
uniprot id: A3U863
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

216432:CA2559 RS07065
gene id: 216432:CA2559_RS07065
uniprot id: A3U8D7
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS06340
gene id: 216432:CA2559_RS06340
uniprot id: A3U7Y8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

216432:CA2559 RS11020
gene id: 216432:CA2559_RS11020
uniprot id: A3U9V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

216432:CA2559 RS04630
gene id: 216432:CA2559_RS04630
uniprot id: A3U6Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

216432:CA2559 RS08915
gene id: 216432:CA2559_RS08915
uniprot id: A3UC11
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

216432:CA2559 RS03135
gene id: 216432:CA2559_RS03135
uniprot id: A3U647
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

216432:CA2559 RS00210
gene id: 216432:CA2559_RS00210
uniprot id: A3U4F9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

216432:CA2559 RS00830
gene id: 216432:CA2559_RS00830
uniprot id: A3U4T8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

216432:CA2559 RS01960
gene id: 216432:CA2559_RS01960
uniprot id: A3U5G0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS02685
gene id: 216432:CA2559_RS02685
uniprot id: A3U5V6
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

216432:CA2559 RS01780
gene id: 216432:CA2559_RS01780
uniprot id: A3U5C4
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

216432:CA2559 RS04460
gene id: 216432:CA2559_RS04460
uniprot id: A3U6W0
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

216432:CA2559 RS12420
gene id: 216432:CA2559_RS12420
uniprot id: A3UAN9
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

216432:CA2559 RS09395
gene id: 216432:CA2559_RS09395
uniprot id: A3U8X4
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS04140
gene id: 216432:CA2559_RS04140
uniprot id: A3U6P6
names: Similarity
messages: Belongs to the histone deacetylase family.

216432:CA2559 RS10685
gene id: 216432:CA2559_RS10685
uniprot id: A3U9N4
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS04325
gene id: 216432:CA2559_RS04325
uniprot id: A3U6T3
names: Similarity
messages: Belongs to the Skp family.

216432:CA2559 RS06985
gene id: 216432:CA2559_RS06985
uniprot id: A3U8C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

216432:CA2559 RS05475
gene id: 216432:CA2559_RS05475
uniprot id: A3U7G1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

216432:CA2559 RS04095
gene id: 216432:CA2559_RS04095
uniprot id: A3U6N7
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

216432:CA2559 RS01270
gene id: 216432:CA2559_RS01270
uniprot id: A3U522
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

216432:CA2559 RS01015
gene id: 216432:CA2559_RS01015
uniprot id: A3U4X3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

216432:CA2559 RS03880
gene id: 216432:CA2559_RS03880
uniprot id: A3U6J5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

216432:CA2559 RS11120
gene id: 216432:CA2559_RS11120
uniprot id: A3U9X3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

216432:CA2559 RS03770
gene id: 216432:CA2559_RS03770
uniprot id: A3U6H3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

216432:CA2559 RS11760
gene id: 216432:CA2559_RS11760
uniprot id: A3UAA5
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

216432:CA2559 RS09715
gene id: 216432:CA2559_RS09715
uniprot id: A3U933
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

216432:CA2559 RS06190
gene id: 216432:CA2559_RS06190
uniprot id: A3U7V7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

216432:CA2559 RS04060
gene id: 216432:CA2559_RS04060
uniprot id: A3U6N0
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS04100
gene id: 216432:CA2559_RS04100
uniprot id: A3U6N8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

216432:CA2559 RS01565
gene id: 216432:CA2559_RS01565
uniprot id: A3U581
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

216432:CA2559 RS12595
gene id: 216432:CA2559_RS12595
uniprot id: A3UAS5
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

216432:CA2559 RS10410
gene id: 216432:CA2559_RS10410
uniprot id: A3U9H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

216432:CA2559 RS00500
gene id: 216432:CA2559_RS00500
uniprot id: A3U4M1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

216432:CA2559 RS00825
gene id: 216432:CA2559_RS00825
uniprot id: A3U4T7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

216432:CA2559 RS03515
gene id: 216432:CA2559_RS03515
uniprot id: A3U6C3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

216432:CA2559 RS06605
gene id: 216432:CA2559_RS06605
uniprot id: A3U842
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

216432:CA2559 RS11900
gene id: 216432:CA2559_RS11900
uniprot id: A3UAD4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Lysosome
messages: Secreted

216432:CA2559 RS11035
gene id: 216432:CA2559_RS11035
uniprot id: A3U9V6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS00795
gene id: 216432:CA2559_RS00795
uniprot id: A3U4T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

216432:CA2559 RS05110
gene id: 216432:CA2559_RS05110
uniprot id: A3U788
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

216432:CA2559 RS03755
gene id: 216432:CA2559_RS03755
uniprot id: A3U6H0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

216432:CA2559 RS05400
gene id: 216432:CA2559_RS05400
uniprot id: A3U7E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

216432:CA2559 RS05270
gene id: 216432:CA2559_RS05270
uniprot id: A3U7B9
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

216432:CA2559 RS02095
gene id: 216432:CA2559_RS02095
uniprot id: A3U5I7
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

216432:CA2559 RS06945
gene id: 216432:CA2559_RS06945
uniprot id: A3U8B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

216432:CA2559 RS03775
gene id: 216432:CA2559_RS03775
uniprot id: A3U6H4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

216432:CA2559 RS04860
gene id: 216432:CA2559_RS04860
uniprot id: A3U740
names: Similarity
messages: Belongs to the peptidase S41A family.

216432:CA2559 RS04150
gene id: 216432:CA2559_RS04150
uniprot id: A3U6P8
names: Similarity
messages: Belongs to the peptidase S66 family.

216432:CA2559 RS00675
gene id: 216432:CA2559_RS00675
uniprot id: A3U4Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

216432:CA2559 RS12215
gene id: 216432:CA2559_RS12215
uniprot id: A3UAJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

216432:CA2559 RS10895
gene id: 216432:CA2559_RS10895
uniprot id: A3U9S7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

216432:CA2559 RS08890
gene id: 216432:CA2559_RS08890
uniprot id: A3UC06
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

216432:CA2559 RS07935
gene id: 216432:CA2559_RS07935
uniprot id: A3UBG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

216432:CA2559 RS12085
gene id: 216432:CA2559_RS12085
uniprot id: A3UAH2
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

216432:CA2559 RS01255
gene id: 216432:CA2559_RS01255
uniprot id: A3U519
names: Similarity
messages: Belongs to the glycosyl hydrolase 100 family.

216432:CA2559 RS05145
gene id: 216432:CA2559_RS05145
uniprot id: A3U795
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

216432:CA2559 RS07085
gene id: 216432:CA2559_RS07085
uniprot id: A3U8E1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

216432:CA2559 RS05815
gene id: 216432:CA2559_RS05815
uniprot id: A3U7N0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

216432:CA2559 RS01435
gene id: 216432:CA2559_RS01435
uniprot id: A3U555
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

216432:CA2559 RS07560
gene id: 216432:CA2559_RS07560
uniprot id: A3U8N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

216432:CA2559 RS01105
gene id: 216432:CA2559_RS01105
uniprot id: A3U4Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

216432:CA2559 RS12390
gene id: 216432:CA2559_RS12390
uniprot id: A3UAN3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

216432:CA2559 RS01085
gene id: 216432:CA2559_RS01085
uniprot id: A3U4Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

216432:CA2559 RS10890
gene id: 216432:CA2559_RS10890
uniprot id: A3U9S6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

216432:CA2559 RS03170
gene id: 216432:CA2559_RS03170
uniprot id: A3U654
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase H family.
messages: Binds 2 metal ions per subunit. Manganese or magnesium.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

216432:CA2559 RS02990
gene id: 216432:CA2559_RS02990
uniprot id: A3U617
names: Similarity
messages: Belongs to the GARS family.

216432:CA2559 RS01835
gene id: 216432:CA2559_RS01835
uniprot id: A3U5D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

216432:CA2559 RS00860
gene id: 216432:CA2559_RS00860
uniprot id: A3U4U4
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS08385
gene id: 216432:CA2559_RS08385
uniprot id: A3UBQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

216432:CA2559 RS04675
gene id: 216432:CA2559_RS04675
uniprot id: A3U703
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

216432:CA2559 RS09510
gene id: 216432:CA2559_RS09510
uniprot id: A3U8Z8
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

216432:CA2559 RS04475
gene id: 216432:CA2559_RS04475
uniprot id: A3U6W3
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

216432:CA2559 RS03575
gene id: 216432:CA2559_RS03575
uniprot id: A3U6D5
names: Similarity
messages: Belongs to the peptidase M4 family.

216432:CA2559 RS03560
gene id: 216432:CA2559_RS03560
uniprot id: A3U6D2
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

216432:CA2559 RS05715
gene id: 216432:CA2559_RS05715
uniprot id: A3U7K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

216432:CA2559 RS00125
gene id: 216432:CA2559_RS00125
uniprot id: A3U4E2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

216432:CA2559 RS09820
gene id: 216432:CA2559_RS09820
uniprot id: A3U955
names: Similarity
messages: Belongs to the DAMOX/DASOX family.

216432:CA2559 RS00785
gene id: 216432:CA2559_RS00785
uniprot id: A3U4S9
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

216432:CA2559 RS02125
gene id: 216432:CA2559_RS02125
uniprot id: A3U5J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

216432:CA2559 RS05835
gene id: 216432:CA2559_RS05835
uniprot id: A3U7N4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

216432:CA2559 RS12465
gene id: 216432:CA2559_RS12465
uniprot id: A3UAP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

216432:CA2559 RS02755
gene id: 216432:CA2559_RS02755
uniprot id: A3U5X0
names: Similarity
messages: Belongs to the sigma-54 factor family.

216432:CA2559 RS05935
gene id: 216432:CA2559_RS05935
uniprot id: A3U7Q5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

216432:CA2559 RS10605
gene id: 216432:CA2559_RS10605
uniprot id: A3U9L6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

216432:CA2559 RS08895
gene id: 216432:CA2559_RS08895
uniprot id: A3UC07
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: In the N-terminal section; belongs to the histidinol-phosphatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS04000
gene id: 216432:CA2559_RS04000
uniprot id: A3U6L8
names: Similarity
messages: Belongs to the SCO1/2 family.

216432:CA2559 RS07740
gene id: 216432:CA2559_RS07740
uniprot id: A3UBC3
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

216432:CA2559 RS08185
gene id: 216432:CA2559_RS08185
uniprot id: A3UBL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

216432:CA2559 RS07850
gene id: 216432:CA2559_RS07850
uniprot id: A3UBE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

216432:CA2559 RS08735
gene id: 216432:CA2559_RS08735
uniprot id: A3UBX3
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

216432:CA2559 RS05600
gene id: 216432:CA2559_RS05600
uniprot id: A3U7I4
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

216432:CA2559 RS07685
gene id: 216432:CA2559_RS07685
uniprot id: A3UBB0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS05800
gene id: 216432:CA2559_RS05800
uniprot id: A3U7M7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

216432:CA2559 RS07820
gene id: 216432:CA2559_RS07820
uniprot id: A3UBD9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

216432:CA2559 RS05710
gene id: 216432:CA2559_RS05710
uniprot id: A3U7K7
names: Similarity
messages: Belongs to the SusD family.

216432:CA2559 RS03605
gene id: 216432:CA2559_RS03605
uniprot id: A3U6E0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

216432:CA2559 RS11050
gene id: 216432:CA2559_RS11050
uniprot id: A3U9V9
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

216432:CA2559 RS12045
gene id: 216432:CA2559_RS12045
uniprot id: A3UAG4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

216432:CA2559 RS05795
gene id: 216432:CA2559_RS05795
uniprot id: A3U7M6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

216432:CA2559 RS09175
gene id: 216432:CA2559_RS09175
uniprot id: A3U8T0
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS04040
gene id: 216432:CA2559_RS04040
uniprot id: A3U6M6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

216432:CA2559 RS10765
gene id: 216432:CA2559_RS10765
uniprot id: A3U9Q0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

216432:CA2559 RS11305
gene id: 216432:CA2559_RS11305
uniprot id: A3UA11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

216432:CA2559 RS06170
gene id: 216432:CA2559_RS06170
uniprot id: A3U7V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

216432:CA2559 RS12470
gene id: 216432:CA2559_RS12470
uniprot id: A3UAQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

216432:CA2559 RS01060
gene id: 216432:CA2559_RS01060
uniprot id: A3U4Y2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

216432:CA2559 RS04395
gene id: 216432:CA2559_RS04395
uniprot id: A3U6U7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS03810
gene id: 216432:CA2559_RS03810
uniprot id: A3U6I1
names: Caution
names: Function
names: Similarity
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P).

216432:CA2559 RS11530
gene id: 216432:CA2559_RS11530
uniprot id: A3UA59
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

216432:CA2559 RS08350
gene id: 216432:CA2559_RS08350
uniprot id: A3UBP6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

216432:CA2559 RS07920
gene id: 216432:CA2559_RS07920
uniprot id: A3UBF9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

216432:CA2559 RS11640
gene id: 216432:CA2559_RS11640
uniprot id: A3UA83
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

216432:CA2559 RS02710
gene id: 216432:CA2559_RS02710
uniprot id: A3U5W1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

216432:CA2559 RS00040
gene id: 216432:CA2559_RS00040
uniprot id: A3U4D0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

216432:CA2559 RS11355
gene id: 216432:CA2559_RS11355
uniprot id: A3UA22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

216432:CA2559 RS04050
gene id: 216432:CA2559_RS04050
uniprot id: A3U6M8
names: Similarity
messages: Belongs to the ribF family.

216432:CA2559 RS02130
gene id: 216432:CA2559_RS02130
uniprot id: A3U5J4
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS07090
gene id: 216432:CA2559_RS07090
uniprot id: A3U8E2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

216432:CA2559 RS04245
gene id: 216432:CA2559_RS04245
uniprot id: A3U6R7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

216432:CA2559 RS04825
gene id: 216432:CA2559_RS04825
uniprot id: A3U733
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

216432:CA2559 RS00935
gene id: 216432:CA2559_RS00935
uniprot id: A3U4V7
names: Similarity
messages: Belongs to the sterol desaturase family.

216432:CA2559 RS05445
gene id: 216432:CA2559_RS05445
uniprot id: A3U7F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

216432:CA2559 RS10570
gene id: 216432:CA2559_RS10570
uniprot id: A3U9K9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

216432:CA2559 RS12710
gene id: 216432:CA2559_RS12710
uniprot id: A3UAU9
names: Cofactor
messages: Binds 1 zinc ion per subunit.

216432:CA2559 RS03295
gene id: 216432:CA2559_RS03295
uniprot id: A3U679
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

216432:CA2559 RS13060
gene id: 216432:CA2559_RS13060
uniprot id: A3UB21
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

216432:CA2559 RS12110
gene id: 216432:CA2559_RS12110
uniprot id: A3UAH7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS02865
gene id: 216432:CA2559_RS02865
uniprot id: A3U5Z3
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS03155
gene id: 216432:CA2559_RS03155
uniprot id: A3U651
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

216432:CA2559 RS03490
gene id: 216432:CA2559_RS03490
uniprot id: A3U6B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

216432:CA2559 RS12985
gene id: 216432:CA2559_RS12985
uniprot id: A3UB05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

216432:CA2559 RS12940
gene id: 216432:CA2559_RS12940
uniprot id: A3UAZ6
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

216432:CA2559 RS00565
gene id: 216432:CA2559_RS00565
uniprot id: A3U4N5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS11255
gene id: 216432:CA2559_RS11255
uniprot id: A3UA01
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

216432:CA2559 RS02775
gene id: 216432:CA2559_RS02775
uniprot id: A3U5X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

216432:CA2559 RS12175
gene id: 216432:CA2559_RS12175
uniprot id: A3UAJ1
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

216432:CA2559 RS13075
gene id: 216432:CA2559_RS13075
uniprot id: A3UB24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

216432:CA2559 RS08685
gene id: 216432:CA2559_RS08685
uniprot id: A3UBW3
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

216432:CA2559 RS03380
gene id: 216432:CA2559_RS03380
uniprot id: A3U696
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

216432:CA2559 RS10265
gene id: 216432:CA2559_RS10265
uniprot id: A3U9E7
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS03140
gene id: 216432:CA2559_RS03140
uniprot id: A3U648
names: Similarity
messages: Belongs to the pyruvate kinase family.

216432:CA2559 RS04605
gene id: 216432:CA2559_RS04605
uniprot id: A3U6Y9
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.

216432:CA2559 RS09670
gene id: 216432:CA2559_RS09670
uniprot id: A3U924
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

216432:CA2559 RS04735
gene id: 216432:CA2559_RS04735
uniprot id: A3U715
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

216432:CA2559 RS13125
gene id: 216432:CA2559_RS13125
uniprot id: A3UB34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

216432:CA2559 RS02365
gene id: 216432:CA2559_RS02365
uniprot id: A3U5P2
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

216432:CA2559 RS07385
gene id: 216432:CA2559_RS07385
uniprot id: A3U8K2
names: Function
names: Similarity
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

216432:CA2559 RS07415
gene id: 216432:CA2559_RS07415
uniprot id: A3U8K8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

216432:CA2559 RS04600
gene id: 216432:CA2559_RS04600
uniprot id: A3U6Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

216432:CA2559 RS05750
gene id: 216432:CA2559_RS05750
uniprot id: A3U7L6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

216432:CA2559 RS08205
gene id: 216432:CA2559_RS08205
uniprot id: A3UBL6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

216432:CA2559 RS07335
gene id: 216432:CA2559_RS07335
uniprot id: A3U8J2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

216432:CA2559 RS02410
gene id: 216432:CA2559_RS02410
uniprot id: A3U5Q1
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS07485
gene id: 216432:CA2559_RS07485
uniprot id: A3U8M2
names: Similarity
messages: Belongs to the glutamine synthetase family.

216432:CA2559 RS01990
gene id: 216432:CA2559_RS01990
uniprot id: A3U5G6
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

216432:CA2559 RS04175
gene id: 216432:CA2559_RS04175
uniprot id: A3U6Q3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

216432:CA2559 RS07515
gene id: 216432:CA2559_RS07515
uniprot id: A3U8M8
names: Similarity
messages: Belongs to the heat shock protein 90 family.

216432:CA2559 RS09565
gene id: 216432:CA2559_RS09565
uniprot id: A3U908
names: Similarity
messages: Belongs to the peptidase S51 family.

216432:CA2559 RS05480
gene id: 216432:CA2559_RS05480
uniprot id: A3U7G2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

216432:CA2559 RS00275
gene id: 216432:CA2559_RS00275
uniprot id: A3U4H3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS12755
gene id: 216432:CA2559_RS12755
uniprot id: A3UAV8
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

216432:CA2559 RS08420
gene id: 216432:CA2559_RS08420
uniprot id: A3UBR0
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS10215
gene id: 216432:CA2559_RS10215
uniprot id: A3U9D7
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

216432:CA2559 RS04055
gene id: 216432:CA2559_RS04055
uniprot id: A3U6M9
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS05755
gene id: 216432:CA2559_RS05755
uniprot id: A3U7L7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

216432:CA2559 RS11110
gene id: 216432:CA2559_RS11110
uniprot id: A3U9X1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

216432:CA2559 RS05725
gene id: 216432:CA2559_RS05725
uniprot id: A3U7L1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

216432:CA2559 RS10205
gene id: 216432:CA2559_RS10205
uniprot id: A3U9D5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

216432:CA2559 RS08110
gene id: 216432:CA2559_RS08110
uniprot id: A3UBJ8
names: Similarity
messages: Belongs to the peptidase M16 family.

216432:CA2559 RS03355
gene id: 216432:CA2559_RS03355
uniprot id: A3U691
names: Similarity
messages: Belongs to the Skp family.

216432:CA2559 RS02000
gene id: 216432:CA2559_RS02000
uniprot id: A3U5G8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

216432:CA2559 RS09725
gene id: 216432:CA2559_RS09725
uniprot id: A3U935
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS04390
gene id: 216432:CA2559_RS04390
uniprot id: A3U6U6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

216432:CA2559 RS12140
gene id: 216432:CA2559_RS12140
uniprot id: A3UAI4
names: Similarity
messages: Belongs to the malate synthase family.

216432:CA2559 RS05830
gene id: 216432:CA2559_RS05830
uniprot id: A3U7N3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

216432:CA2559 RS00265
gene id: 216432:CA2559_RS00265
uniprot id: A3U4H1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

216432:CA2559 RS12575
gene id: 216432:CA2559_RS12575
uniprot id: A3UAS1
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

216432:CA2559 RS03445
gene id: 216432:CA2559_RS03445
uniprot id: A3U6A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

216432:CA2559 RS13315
gene id: 216432:CA2559_RS13315
uniprot id: A3UB72
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS06260
gene id: 216432:CA2559_RS06260
uniprot id: A3U7X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane

216432:CA2559 RS04385
gene id: 216432:CA2559_RS04385
uniprot id: A3U6U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Cytoplasm

216432:CA2559 RS03610
gene id: 216432:CA2559_RS03610
uniprot id: A3U6E1
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS08875
gene id: 216432:CA2559_RS08875
uniprot id: A3UC03
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

216432:CA2559 RS08295
gene id: 216432:CA2559_RS08295
uniprot id: A3UBN5
names: Similarity
messages: Belongs to the SAICAR synthetase family.

216432:CA2559 RS00050
gene id: 216432:CA2559_RS00050
uniprot id: A3U4D2
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

216432:CA2559 RS08840
gene id: 216432:CA2559_RS08840
uniprot id: A3UBZ5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

216432:CA2559 RS01280
gene id: 216432:CA2559_RS01280
uniprot id: A3U524
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

216432:CA2559 RS01195
gene id: 216432:CA2559_RS01195
uniprot id: A3U507
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell inner membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

216432:CA2559 RS09550
gene id: 216432:CA2559_RS09550
uniprot id: A3U905
names: Similarity
messages: Belongs to the peptidase S14 family.

216432:CA2559 RS06095
gene id: 216432:CA2559_RS06095
uniprot id: A3U7T8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

216432:CA2559 RS04350
gene id: 216432:CA2559_RS04350
uniprot id: A3U6T8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS06510
gene id: 216432:CA2559_RS06510
uniprot id: A3U823
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

216432:CA2559 RS03245
gene id: 216432:CA2559_RS03245
uniprot id: A3U670
names: Cofactor
messages: Binds 1 zinc ion per subunit.

216432:CA2559 RS10110
gene id: 216432:CA2559_RS10110
uniprot id: A3U9B6
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.

216432:CA2559 RS08870
gene id: 216432:CA2559_RS08870
uniprot id: A3UC02
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

216432:CA2559 RS03845
gene id: 216432:CA2559_RS03845
uniprot id: A3U6I8
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS02505
gene id: 216432:CA2559_RS02505
uniprot id: A3U5S0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

216432:CA2559 RS05680
gene id: 216432:CA2559_RS05680
uniprot id: A3U7K1
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS00415
gene id: 216432:CA2559_RS00415
uniprot id: A3U4K4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

216432:CA2559 RS12080
gene id: 216432:CA2559_RS12080
uniprot id: A3UAH1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

216432:CA2559 RS03240
gene id: 216432:CA2559_RS03240
uniprot id: A3U669
names: Similarity
messages: Belongs to the peptidase S8 family.

216432:CA2559 RS01140
gene id: 216432:CA2559_RS01140
uniprot id: A3U4Z6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

216432:CA2559 RS02460
gene id: 216432:CA2559_RS02460
uniprot id: A3U5R1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 3-HAO family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

216432:CA2559 RS11705
gene id: 216432:CA2559_RS11705
uniprot id: A3UA94
names: Similarity
messages: Belongs to the peptidase C40 family.

216432:CA2559 RS05410
gene id: 216432:CA2559_RS05410
uniprot id: A3U7E8
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

216432:CA2559 RS11295
gene id: 216432:CA2559_RS11295
uniprot id: A3UA09
names: Function
names: Similarity
messages: Belongs to the catalase family. HPII subfamily.
messages: Serves to protect cells from the toxic effects of hydrogen peroxide.

216432:CA2559 RS06840
gene id: 216432:CA2559_RS06840
uniprot id: A3U889
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

216432:CA2559 RS11000
gene id: 216432:CA2559_RS11000
uniprot id: A3U9V0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

216432:CA2559 RS09915
gene id: 216432:CA2559_RS09915
uniprot id: A3U974
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

216432:CA2559 RS04185
gene id: 216432:CA2559_RS04185
uniprot id: A3U6Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

216432:CA2559 RS09620
gene id: 216432:CA2559_RS09620
uniprot id: A3U919
names: Similarity
messages: Belongs to the type IB topoisomerase family.

216432:CA2559 RS11820
gene id: 216432:CA2559_RS11820
uniprot id: A3UAB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

216432:CA2559 RS09325
gene id: 216432:CA2559_RS09325
uniprot id: A3U8W0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

216432:CA2559 RS00815
gene id: 216432:CA2559_RS00815
uniprot id: A3U4T5
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS11985
gene id: 216432:CA2559_RS11985
uniprot id: A3UAF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

216432:CA2559 RS05140
gene id: 216432:CA2559_RS05140
uniprot id: A3U794
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS13365
gene id: 216432:CA2559_RS13365
uniprot id: A3UB82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

216432:CA2559 RS06255
gene id: 216432:CA2559_RS06255
uniprot id: A3U7X0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

216432:CA2559 RS12230
gene id: 216432:CA2559_RS12230
uniprot id: A3UAK2
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS02530
gene id: 216432:CA2559_RS02530
uniprot id: A3U5S5
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

216432:CA2559 RS03675
gene id: 216432:CA2559_RS03675
uniprot id: A3U6F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

216432:CA2559 RS07890
gene id: 216432:CA2559_RS07890
uniprot id: A3UBF3
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

216432:CA2559 RS12075
gene id: 216432:CA2559_RS12075
uniprot id: A3UAH0
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS02430
gene id: 216432:CA2559_RS02430
uniprot id: A3U5Q5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS13675
gene id: 216432:CA2559_RS13675
uniprot id: A3U7N8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

216432:CA2559 RS06105
gene id: 216432:CA2559_RS06105
uniprot id: A3U7U0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

216432:CA2559 RS00925
gene id: 216432:CA2559_RS00925
uniprot id: A3U4V5
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

216432:CA2559 RS01190
gene id: 216432:CA2559_RS01190
uniprot id: A3U506
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

216432:CA2559 RS06505
gene id: 216432:CA2559_RS06505
uniprot id: A3U822
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

216432:CA2559 RS01350
gene id: 216432:CA2559_RS01350
uniprot id: A3U539
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

216432:CA2559 RS12305
gene id: 216432:CA2559_RS12305
uniprot id: A3UAL7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

216432:CA2559 RS02380
gene id: 216432:CA2559_RS02380
uniprot id: A3U5P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 51 family.
messages: Cell inner membrane
messages: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.

216432:CA2559 RS12915
gene id: 216432:CA2559_RS12915
uniprot id: A3UAZ1
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

216432:CA2559 RS00865
gene id: 216432:CA2559_RS00865
uniprot id: A3U4U5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS05050
gene id: 216432:CA2559_RS05050
uniprot id: A3U776
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

216432:CA2559 RS10390
gene id: 216432:CA2559_RS10390
uniprot id: A3U9H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

216432:CA2559 RS06530
gene id: 216432:CA2559_RS06530
uniprot id: A3U827
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS09185
gene id: 216432:CA2559_RS09185
uniprot id: A3U8T2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

216432:CA2559 RS10695
gene id: 216432:CA2559_RS10695
uniprot id: A3U9N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

216432:CA2559 RS00055
gene id: 216432:CA2559_RS00055
uniprot id: A3U4D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

216432:CA2559 RS11700
gene id: 216432:CA2559_RS11700
uniprot id: A3UA93
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

216432:CA2559 RS08165
gene id: 216432:CA2559_RS08165
uniprot id: A3UBK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

216432:CA2559 RS00800
gene id: 216432:CA2559_RS00800
uniprot id: A3U4T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

216432:CA2559 RS06590
gene id: 216432:CA2559_RS06590
uniprot id: A3U839
names: Similarity
messages: Belongs to the NAD synthetase family.

216432:CA2559 RS10990
gene id: 216432:CA2559_RS10990
uniprot id: A3U9U6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

216432:CA2559 RS12145
gene id: 216432:CA2559_RS12145
uniprot id: A3UAI5
names: Cofactor
messages: Can also use Mn(2+) ion.

216432:CA2559 RS01365
gene id: 216432:CA2559_RS01365
uniprot id: A3U542
names: Similarity
messages: Belongs to the universal stress protein A family.

216432:CA2559 RS13870
gene id: 216432:CA2559_RS13870
uniprot id: A3UBN1
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS12180
gene id: 216432:CA2559_RS12180
uniprot id: A3UAJ2
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

216432:CA2559 RS08440
gene id: 216432:CA2559_RS08440
uniprot id: A3UBR4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

216432:CA2559 RS05875
gene id: 216432:CA2559_RS05875
uniprot id: A3U7P3
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

216432:CA2559 RS06405
gene id: 216432:CA2559_RS06405
uniprot id: A3U801
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS00065
gene id: 216432:CA2559_RS00065
uniprot id: A3U4D4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

216432:CA2559 RS06545
gene id: 216432:CA2559_RS06545
uniprot id: A3U830
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS09695
gene id: 216432:CA2559_RS09695
uniprot id: A3U929
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

216432:CA2559 RS05605
gene id: 216432:CA2559_RS05605
uniprot id: A3U7I5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS09180
gene id: 216432:CA2559_RS09180
uniprot id: A3U8T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

216432:CA2559 RS12105
gene id: 216432:CA2559_RS12105
uniprot id: A3UAH6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

216432:CA2559 RS02575
gene id: 216432:CA2559_RS02575
uniprot id: A3U5T4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

216432:CA2559 RS08675
gene id: 216432:CA2559_RS08675
uniprot id: A3UBW1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

216432:CA2559 RS01500
gene id: 216432:CA2559_RS01500
uniprot id: A3U568
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

216432:CA2559 RS11980
gene id: 216432:CA2559_RS11980
uniprot id: A3UAF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

216432:CA2559 RS06005
gene id: 216432:CA2559_RS06005
uniprot id: A3U7S0
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

216432:CA2559 RS01300
gene id: 216432:CA2559_RS01300
uniprot id: A3U528
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

216432:CA2559 RS10835
gene id: 216432:CA2559_RS10835
uniprot id: A3U9R5
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

216432:CA2559 RS07455
gene id: 216432:CA2559_RS07455
uniprot id: A3U8L6
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

216432:CA2559 RS12965
gene id: 216432:CA2559_RS12965
uniprot id: A3UB01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

216432:CA2559 RS04845
gene id: 216432:CA2559_RS04845
uniprot id: A3U737
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

216432:CA2559 RS02385
gene id: 216432:CA2559_RS02385
uniprot id: A3U5P6
names: Similarity
messages: Belongs to the Vsr family.

216432:CA2559 RS02445
gene id: 216432:CA2559_RS02445
uniprot id: A3U5Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

216432:CA2559 RS01630
gene id: 216432:CA2559_RS01630
uniprot id: A3U594
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS05865
gene id: 216432:CA2559_RS05865
uniprot id: A3U7P1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

216432:CA2559 RS09910
gene id: 216432:CA2559_RS09910
uniprot id: A3U973
names: Similarity
messages: Belongs to the glutamate synthase family.

216432:CA2559 RS00045
gene id: 216432:CA2559_RS00045
uniprot id: A3U4D1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

216432:CA2559 RS03220
gene id: 216432:CA2559_RS03220
uniprot id: A3U665
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

216432:CA2559 RS06650
gene id: 216432:CA2559_RS06650
uniprot id: A3U851
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

216432:CA2559 RS03070
gene id: 216432:CA2559_RS03070
uniprot id: A3U633
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

216432:CA2559 RS07070
gene id: 216432:CA2559_RS07070
uniprot id: A3U8D8
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS03060
gene id: 216432:CA2559_RS03060
uniprot id: A3U631
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

216432:CA2559 RS08405
gene id: 216432:CA2559_RS08405
uniprot id: A3UBQ7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

216432:CA2559 RS09585
gene id: 216432:CA2559_RS09585
uniprot id: A3U912
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

216432:CA2559 RS04070
gene id: 216432:CA2559_RS04070
uniprot id: A3U6N2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

216432:CA2559 RS08445
gene id: 216432:CA2559_RS08445
uniprot id: A3UBR5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

216432:CA2559 RS12405
gene id: 216432:CA2559_RS12405
uniprot id: A3UAN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

216432:CA2559 RS00850
gene id: 216432:CA2559_RS00850
uniprot id: A3U4U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

216432:CA2559 RS07155
gene id: 216432:CA2559_RS07155
uniprot id: A3U8F6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

216432:CA2559 RS09415
gene id: 216432:CA2559_RS09415
uniprot id: A3U8X8
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

216432:CA2559 RS08975
gene id: 216432:CA2559_RS08975
uniprot id: A3UC23
names: Similarity
messages: Belongs to the pirin family.

216432:CA2559 RS03660
gene id: 216432:CA2559_RS03660
uniprot id: A3U6F1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

216432:CA2559 RS13410
gene id: 216432:CA2559_RS13410
uniprot id: A3UB92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

216432:CA2559 RS11975
gene id: 216432:CA2559_RS11975
uniprot id: A3UAF0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrF family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

216432:CA2559 RS07625
gene id: 216432:CA2559_RS07625
uniprot id: A3U8Q0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

216432:CA2559 RS04920
gene id: 216432:CA2559_RS04920
uniprot id: A3U752
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

216432:CA2559 RS00110
gene id: 216432:CA2559_RS00110
uniprot id: A3U4D9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

216432:CA2559 RS03945
gene id: 216432:CA2559_RS03945
uniprot id: A3U6K8
names: Similarity
messages: Belongs to the peptidase M13 family.

216432:CA2559 RS12295
gene id: 216432:CA2559_RS12295
uniprot id: A3UAL5
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

216432:CA2559 RS08630
gene id: 216432:CA2559_RS08630
uniprot id: A3UBV2
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS00215
gene id: 216432:CA2559_RS00215
uniprot id: A3U4G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

216432:CA2559 RS07400
gene id: 216432:CA2559_RS07400
uniprot id: A3U8K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

216432:CA2559 RS06025
gene id: 216432:CA2559_RS06025
uniprot id: A3U7S4
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

216432:CA2559 RS00585
gene id: 216432:CA2559_RS00585
uniprot id: A3U4N9
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS01795
gene id: 216432:CA2559_RS01795
uniprot id: A3U5C7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

216432:CA2559 RS07490
gene id: 216432:CA2559_RS07490
uniprot id: A3U8M3
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS07145
gene id: 216432:CA2559_RS07145
uniprot id: A3U8F3
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS11665
gene id: 216432:CA2559_RS11665
uniprot id: A3UA88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

216432:CA2559 RS05420
gene id: 216432:CA2559_RS05420
uniprot id: A3U7F0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS07670
gene id: 216432:CA2559_RS07670
uniprot id: A3UBA7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

216432:CA2559 RS00030
gene id: 216432:CA2559_RS00030
uniprot id: A3U4C8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

216432:CA2559 RS03485
gene id: 216432:CA2559_RS03485
uniprot id: A3U6B6
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

216432:CA2559 RS03075
gene id: 216432:CA2559_RS03075
uniprot id: A3U634
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

216432:CA2559 RS12560
gene id: 216432:CA2559_RS12560
uniprot id: A3UAR8
names: Similarity
messages: Belongs to the IMPACT family.

216432:CA2559 RS08540
gene id: 216432:CA2559_RS08540
uniprot id: A3UBT4
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

216432:CA2559 RS12895
gene id: 216432:CA2559_RS12895
uniprot id: A3UAY7
names: Similarity
messages: Belongs to the polysaccharide synthase family.

216432:CA2559 RS02120
gene id: 216432:CA2559_RS02120
uniprot id: A3U5J2
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS05940
gene id: 216432:CA2559_RS05940
uniprot id: A3U7Q6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

216432:CA2559 RS00135
gene id: 216432:CA2559_RS00135
uniprot id: A3U4E4
names: Similarity
messages: Belongs to the peptidase S8 family.

216432:CA2559 RS09475
gene id: 216432:CA2559_RS09475
uniprot id: A3U8Z1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS03525
gene id: 216432:CA2559_RS03525
uniprot id: A3U6C5
names: Similarity
messages: Belongs to the DprA/Smf family.

216432:CA2559 RS01150
gene id: 216432:CA2559_RS01150
uniprot id: A3U4Z8
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS09150
gene id: 216432:CA2559_RS09150
uniprot id: A3U8S5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS13190
gene id: 216432:CA2559_RS13190
uniprot id: A3UB47
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

216432:CA2559 RS12185
gene id: 216432:CA2559_RS12185
uniprot id: A3UAJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

216432:CA2559 RS11960
gene id: 216432:CA2559_RS11960
uniprot id: A3UAE7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

216432:CA2559 RS06185
gene id: 216432:CA2559_RS06185
uniprot id: A3U7V6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

216432:CA2559 RS11545
gene id: 216432:CA2559_RS11545
uniprot id: A3UA63
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

216432:CA2559 RS04410
gene id: 216432:CA2559_RS04410
uniprot id: A3U6V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Membrane

216432:CA2559 RS13040
gene id: 216432:CA2559_RS13040
uniprot id: A3UB16
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS05735
gene id: 216432:CA2559_RS05735
uniprot id: A3U7L3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

216432:CA2559 RS04710
gene id: 216432:CA2559_RS04710
uniprot id: A3U710
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

216432:CA2559 RS13380
gene id: 216432:CA2559_RS13380
uniprot id: A3UB86
names: Similarity
messages: Belongs to the CinA family.

216432:CA2559 RS10355
gene id: 216432:CA2559_RS10355
uniprot id: A3U9G5
names: Similarity
messages: Belongs to the peptidase M1 family.

216432:CA2559 RS12935
gene id: 216432:CA2559_RS12935
uniprot id: A3UAZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

216432:CA2559 RS04400
gene id: 216432:CA2559_RS04400
uniprot id: A3U6U8
names: Caution
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

216432:CA2559 RS05485
gene id: 216432:CA2559_RS05485
uniprot id: A3U7G3
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

216432:CA2559 RS06575
gene id: 216432:CA2559_RS06575
uniprot id: A3U836
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

216432:CA2559 RS05320
gene id: 216432:CA2559_RS05320
uniprot id: A3U7C9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

216432:CA2559 RS03700
gene id: 216432:CA2559_RS03700
uniprot id: A3U6F9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

216432:CA2559 RS06400
gene id: 216432:CA2559_RS06400
uniprot id: A3U800
names: Similarity
messages: Belongs to the TrpC family.

216432:CA2559 RS06165
gene id: 216432:CA2559_RS06165
uniprot id: A3U7V2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

216432:CA2559 RS02260
gene id: 216432:CA2559_RS02260
uniprot id: A3U5M1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

216432:CA2559 RS08745
gene id: 216432:CA2559_RS08745
uniprot id: A3UBX5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

216432:CA2559 RS02425
gene id: 216432:CA2559_RS02425
uniprot id: A3U5Q4
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

216432:CA2559 RS09760
gene id: 216432:CA2559_RS09760
uniprot id: A3U942
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

216432:CA2559 RS01055
gene id: 216432:CA2559_RS01055
uniprot id: A3U4Y1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS11620
gene id: 216432:CA2559_RS11620
uniprot id: A3UA78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

216432:CA2559 RS04205
gene id: 216432:CA2559_RS04205
uniprot id: A3U6Q9
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

216432:CA2559 RS01525
gene id: 216432:CA2559_RS01525
uniprot id: A3U573
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

216432:CA2559 RS07530
gene id: 216432:CA2559_RS07530
uniprot id: A3U8N1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

216432:CA2559 RS00105
gene id: 216432:CA2559_RS00105
uniprot id: A3U4D8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

216432:CA2559 RS07985
gene id: 216432:CA2559_RS07985
uniprot id: A3UBH3
names: Similarity
messages: Belongs to the threonine aldolase family.

216432:CA2559 RS03425
gene id: 216432:CA2559_RS03425
uniprot id: A3U6A5
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

216432:CA2559 RS10425
gene id: 216432:CA2559_RS10425
uniprot id: A3U9H9
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS12615
gene id: 216432:CA2559_RS12615
uniprot id: A3UAS9
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

216432:CA2559 RS02085
gene id: 216432:CA2559_RS02085
uniprot id: A3U5I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

216432:CA2559 RS04075
gene id: 216432:CA2559_RS04075
uniprot id: A3U6N3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS08355
gene id: 216432:CA2559_RS08355
uniprot id: A3UBP7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

216432:CA2559 RS05990
gene id: 216432:CA2559_RS05990
uniprot id: A3U7R7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

216432:CA2559 RS10175
gene id: 216432:CA2559_RS10175
uniprot id: A3U9C9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

216432:CA2559 RS05810
gene id: 216432:CA2559_RS05810
uniprot id: A3U7M9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

216432:CA2559 RS13435
gene id: 216432:CA2559_RS13435
uniprot id: A3UB97
names: Similarity
messages: Belongs to the AIR synthase family.

216432:CA2559 RS08335
gene id: 216432:CA2559_RS08335
uniprot id: A3UBP3
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS03620
gene id: 216432:CA2559_RS03620
uniprot id: A3U6E3
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

216432:CA2559 RS08005
gene id: 216432:CA2559_RS08005
uniprot id: A3UBH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

216432:CA2559 RS12570
gene id: 216432:CA2559_RS12570
uniprot id: A3UAS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

216432:CA2559 RS04450
gene id: 216432:CA2559_RS04450
uniprot id: A3U6V8
names: Cofactor
names: PTM
names: Subcellular Location Annotation
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.
messages: Periplasm

216432:CA2559 RS09445
gene id: 216432:CA2559_RS09445
uniprot id: A3U8Y4
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS08170
gene id: 216432:CA2559_RS08170
uniprot id: A3UBK9
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

216432:CA2559 RS02825
gene id: 216432:CA2559_RS02825
uniprot id: A3U5Y4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

216432:CA2559 RS08320
gene id: 216432:CA2559_RS08320
uniprot id: A3UBP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

216432:CA2559 RS07925
gene id: 216432:CA2559_RS07925
uniprot id: A3UBG0
names: Similarity
messages: Belongs to the UPF0246 family.

216432:CA2559 RS05775
gene id: 216432:CA2559_RS05775
uniprot id: A3U7M1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

216432:CA2559 RS08935
gene id: 216432:CA2559_RS08935
uniprot id: A3UC15
names: Similarity
messages: Belongs to the arginase family.

216432:CA2559 RS10145
gene id: 216432:CA2559_RS10145
uniprot id: A3U9C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

216432:CA2559 RS08485
gene id: 216432:CA2559_RS08485
uniprot id: A3UBS3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

216432:CA2559 RS02025
gene id: 216432:CA2559_RS02025
uniprot id: A3U5H3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

216432:CA2559 RS05745
gene id: 216432:CA2559_RS05745
uniprot id: A3U7L5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

216432:CA2559 RS04855
gene id: 216432:CA2559_RS04855
uniprot id: A3U739
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

216432:CA2559 RS01570
gene id: 216432:CA2559_RS01570
uniprot id: A3U582
names: Similarity
messages: Belongs to the UPF0045 family.

216432:CA2559 RS02360
gene id: 216432:CA2559_RS02360
uniprot id: A3U5P1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

216432:CA2559 RS02315
gene id: 216432:CA2559_RS02315
uniprot id: A3U5N2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS06830
gene id: 216432:CA2559_RS06830
uniprot id: A3U887
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

216432:CA2559 RS04145
gene id: 216432:CA2559_RS04145
uniprot id: A3U6P7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

216432:CA2559 RS02935
gene id: 216432:CA2559_RS02935
uniprot id: A3U606
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS01245
gene id: 216432:CA2559_RS01245
uniprot id: A3U517
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS04670
gene id: 216432:CA2559_RS04670
uniprot id: A3U702
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).

216432:CA2559 RS00885
gene id: 216432:CA2559_RS00885
uniprot id: A3U4U9
names: Similarity
messages: Belongs to the HSP15 family.

216432:CA2559 RS10560
gene id: 216432:CA2559_RS10560
uniprot id: A3U9K7
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

216432:CA2559 RS04940
gene id: 216432:CA2559_RS04940
uniprot id: A3U756
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

216432:CA2559 RS11770
gene id: 216432:CA2559_RS11770
uniprot id: A3UAA7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS06475
gene id: 216432:CA2559_RS06475
uniprot id: A3U816
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

216432:CA2559 RS05850
gene id: 216432:CA2559_RS05850
uniprot id: A3U7N7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

216432:CA2559 RS06645
gene id: 216432:CA2559_RS06645
uniprot id: A3U850
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

216432:CA2559 RS11330
gene id: 216432:CA2559_RS11330
uniprot id: A3UA17
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS02440
gene id: 216432:CA2559_RS02440
uniprot id: A3U5Q7
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS11570
gene id: 216432:CA2559_RS11570
uniprot id: A3UA68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

216432:CA2559 RS03115
gene id: 216432:CA2559_RS03115
uniprot id: A3U642
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

216432:CA2559 RS07775
gene id: 216432:CA2559_RS07775
uniprot id: A3UBD0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

216432:CA2559 RS04570
gene id: 216432:CA2559_RS04570
uniprot id: A3U6Y2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

216432:CA2559 RS13325
gene id: 216432:CA2559_RS13325
uniprot id: A3UB74
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

216432:CA2559 RS10770
gene id: 216432:CA2559_RS10770
uniprot id: A3U9Q1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

216432:CA2559 RS08460
gene id: 216432:CA2559_RS08460
uniprot id: A3UBR8
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS13100
gene id: 216432:CA2559_RS13100
uniprot id: A3UB29
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

216432:CA2559 RS04835
gene id: 216432:CA2559_RS04835
uniprot id: A3U735
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS10520
gene id: 216432:CA2559_RS10520
uniprot id: A3U9J8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

216432:CA2559 RS02055
gene id: 216432:CA2559_RS02055
uniprot id: A3U5H9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

216432:CA2559 RS11270
gene id: 216432:CA2559_RS11270
uniprot id: A3UA04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

216432:CA2559 RS02735
gene id: 216432:CA2559_RS02735
uniprot id: A3U5W6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

216432:CA2559 RS11060
gene id: 216432:CA2559_RS11060
uniprot id: A3U9W1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

216432:CA2559 RS00010
gene id: 216432:CA2559_RS00010
uniprot id: A3U4C4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

216432:CA2559 RS06525
gene id: 216432:CA2559_RS06525
uniprot id: A3U826
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS06175
gene id: 216432:CA2559_RS06175
uniprot id: A3U7V4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

216432:CA2559 RS08680
gene id: 216432:CA2559_RS08680
uniprot id: A3UBW2
names: Similarity
messages: Belongs to the Fur family.

216432:CA2559 RS01510
gene id: 216432:CA2559_RS01510
uniprot id: A3U570
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

216432:CA2559 RS04170
gene id: 216432:CA2559_RS04170
uniprot id: A3U6Q2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS03655
gene id: 216432:CA2559_RS03655
uniprot id: A3U6F0
names: Function
names: Similarity
messages: Belongs to the HMBS family.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

216432:CA2559 RS07845
gene id: 216432:CA2559_RS07845
uniprot id: A3UBE4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

216432:CA2559 RS05860
gene id: 216432:CA2559_RS05860
uniprot id: A3U7P0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

216432:CA2559 RS12120
gene id: 216432:CA2559_RS12120
uniprot id: A3UAH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

216432:CA2559 RS01430
gene id: 216432:CA2559_RS01430
uniprot id: A3U554
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

216432:CA2559 RS06620
gene id: 216432:CA2559_RS06620
uniprot id: A3U845
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

216432:CA2559 RS08655
gene id: 216432:CA2559_RS08655
uniprot id: A3UBV7
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

216432:CA2559 RS04020
gene id: 216432:CA2559_RS04020
uniprot id: A3U6M3
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

216432:CA2559 RS02355
gene id: 216432:CA2559_RS02355
uniprot id: A3U5P0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

216432:CA2559 RS09050
gene id: 216432:CA2559_RS09050
uniprot id: A3UC38
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

216432:CA2559 RS12660
gene id: 216432:CA2559_RS12660
uniprot id: A3UAT8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

216432:CA2559 RS11095
gene id: 216432:CA2559_RS11095
uniprot id: A3U9W8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL31 family.

216432:CA2559 RS00505
gene id: 216432:CA2559_RS00505
uniprot id: A3U4M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

216432:CA2559 RS10510
gene id: 216432:CA2559_RS10510
uniprot id: A3U9J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

216432:CA2559 RS10885
gene id: 216432:CA2559_RS10885
uniprot id: A3U9S5
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS10100
gene id: 216432:CA2559_RS10100
uniprot id: A3U9B4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

216432:CA2559 RS12205
gene id: 216432:CA2559_RS12205
uniprot id: A3UAJ7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

216432:CA2559 RS05760
gene id: 216432:CA2559_RS05760
uniprot id: A3U7L8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

216432:CA2559 RS04960
gene id: 216432:CA2559_RS04960
uniprot id: A3U760
names: Cofactor
names: Similarity
messages: Belongs to the nitroreductase family.
messages: Binds 1 FMN per subunit.

216432:CA2559 RS02070
gene id: 216432:CA2559_RS02070
uniprot id: A3U5I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

216432:CA2559 RS00640
gene id: 216432:CA2559_RS00640
uniprot id: A3U4Q0
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

216432:CA2559 RS00595
gene id: 216432:CA2559_RS00595
uniprot id: A3U4P1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS06235
gene id: 216432:CA2559_RS06235
uniprot id: A3U7W6
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

216432:CA2559 RS03080
gene id: 216432:CA2559_RS03080
uniprot id: A3U635
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

216432:CA2559 RS06535
gene id: 216432:CA2559_RS06535
uniprot id: A3U828
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

216432:CA2559 RS05825
gene id: 216432:CA2559_RS05825
uniprot id: A3U7N2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

216432:CA2559 RS07565
gene id: 216432:CA2559_RS07565
uniprot id: A3U8N8
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

216432:CA2559 RS07150
gene id: 216432:CA2559_RS07150
uniprot id: A3U8F5
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

216432:CA2559 RS04790
gene id: 216432:CA2559_RS04790
uniprot id: A3U726
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

216432:CA2559 RS11315
gene id: 216432:CA2559_RS11315
uniprot id: A3UA13
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

216432:CA2559 RS06775
gene id: 216432:CA2559_RS06775
uniprot id: A3U876
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

216432:CA2559 RS07230
gene id: 216432:CA2559_RS07230
uniprot id: A3U8H1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

216432:CA2559 RS02225
gene id: 216432:CA2559_RS02225
uniprot id: A3U5L3
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

216432:CA2559 RS09350
gene id: 216432:CA2559_RS09350
uniprot id: A3U8W5
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

216432:CA2559 RS06125
gene id: 216432:CA2559_RS06125
uniprot id: A3U7U4
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

216432:CA2559 RS03630
gene id: 216432:CA2559_RS03630
uniprot id: A3U6E5
names: Subunit
messages: Homodimer.

216432:CA2559 RS08985
gene id: 216432:CA2559_RS08985
uniprot id: A3UC25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

216432:CA2559 RS07755
gene id: 216432:CA2559_RS07755
uniprot id: A3UBC6
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

216432:CA2559 RS08285
gene id: 216432:CA2559_RS08285
uniprot id: A3UBN3
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

216432:CA2559 RS04840
gene id: 216432:CA2559_RS04840
uniprot id: A3U736
names: Similarity
messages: Belongs to the peptidase C40 family.

216432:CA2559 RS09890
gene id: 216432:CA2559_RS09890
uniprot id: A3U969
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

216432:CA2559 RS09275
gene id: 216432:CA2559_RS09275
uniprot id: A3U8V0
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

216432:CA2559 RS03615
gene id: 216432:CA2559_RS03615
uniprot id: A3U6E2
names: Similarity
messages: Belongs to the Nudix hydrolase family.

216432:CA2559 RS08885
gene id: 216432:CA2559_RS08885
uniprot id: A3UC05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

216432:CA2559 RS01200
gene id: 216432:CA2559_RS01200
uniprot id: A3U508
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.
messages: Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.
messages: Monomer.
messages: Periplasm

216432:CA2559 RS03895
gene id: 216432:CA2559_RS03895
uniprot id: A3U6J8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

216432:CA2559 RS05765
gene id: 216432:CA2559_RS05765
uniprot id: A3U7L9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

216432:CA2559 RS11040
gene id: 216432:CA2559_RS11040
uniprot id: A3U9V7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

216432:CA2559 RS08810
gene id: 216432:CA2559_RS08810
uniprot id: A3UBY9
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

216432:CA2559 RS06560
gene id: 216432:CA2559_RS06560
uniprot id: A3U833
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

216432:CA2559 RS13340
gene id: 216432:CA2559_RS13340
uniprot id: A3UB77
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS00790
gene id: 216432:CA2559_RS00790
uniprot id: A3U4T0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

216432:CA2559 RS00525
gene id: 216432:CA2559_RS00525
uniprot id: A3U4M6
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

216432:CA2559 RS02700
gene id: 216432:CA2559_RS02700
uniprot id: A3U5V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

216432:CA2559 RS08070
gene id: 216432:CA2559_RS08070
uniprot id: A3UBJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

216432:CA2559 RS12000
gene id: 216432:CA2559_RS12000
uniprot id: A3UAF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

216432:CA2559 RS05595
gene id: 216432:CA2559_RS05595
uniprot id: A3U7I3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

216432:CA2559 RS12455
gene id: 216432:CA2559_RS12455
uniprot id: A3UAP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

216432:CA2559 RS06390
gene id: 216432:CA2559_RS06390
uniprot id: A3U7Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

216432:CA2559 RS09930
gene id: 216432:CA2559_RS09930
uniprot id: A3U977
names: Similarity
messages: Belongs to the LOG family.

216432:CA2559 RS13595
gene id: 216432:CA2559_RS13595
uniprot id: A3UC18
names: Similarity
messages: Belongs to the peptidase M4 family.

216432:CA2559 RS02610
gene id: 216432:CA2559_RS02610
uniprot id: A3U5U1
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

216432:CA2559 RS09560
gene id: 216432:CA2559_RS09560
uniprot id: A3U907
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

216432:CA2559 RS04690
gene id: 216432:CA2559_RS04690
uniprot id: A3U706
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

216432:CA2559 RS01450
gene id: 216432:CA2559_RS01450
uniprot id: A3U558
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

216432:CA2559 RS12535
gene id: 216432:CA2559_RS12535
uniprot id: A3UAR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

216432:CA2559 RS02065
gene id: 216432:CA2559_RS02065
uniprot id: A3U5I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

216432:CA2559 RS01360
gene id: 216432:CA2559_RS01360
uniprot id: A3U541
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

216432:CA2559 RS00650
gene id: 216432:CA2559_RS00650
uniprot id: A3U4Q2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

216432:CA2559 RS02950
gene id: 216432:CA2559_RS02950
uniprot id: A3U609
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS04105
gene id: 216432:CA2559_RS04105
uniprot id: A3U6N9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

216432:CA2559 RS06640
gene id: 216432:CA2559_RS06640
uniprot id: A3U849
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
messages: Membrane

216432:CA2559 RS00760
gene id: 216432:CA2559_RS00760
uniprot id: A3U4S4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

216432:CA2559 RS13005
gene id: 216432:CA2559_RS13005
uniprot id: A3UB09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

216432:CA2559 RS08690
gene id: 216432:CA2559_RS08690
uniprot id: A3UBW4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

216432:CA2559 RS09800
gene id: 216432:CA2559_RS09800
uniprot id: A3U951
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

216432:CA2559 RS11860
gene id: 216432:CA2559_RS11860
uniprot id: A3UAC5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

216432:CA2559 RS05560
gene id: 216432:CA2559_RS05560
uniprot id: A3U7I0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

216432:CA2559 RS12775
gene id: 216432:CA2559_RS12775
uniprot id: A3UAW2
names: Similarity
messages: Belongs to the AHA1 family.

216432:CA2559 RS01915
gene id: 216432:CA2559_RS01915
uniprot id: A3U5F1
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS02930
gene id: 216432:CA2559_RS02930
uniprot id: A3U605
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

216432:CA2559 RS05995
gene id: 216432:CA2559_RS05995
uniprot id: A3U7R8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

216432:CA2559 RS04550
gene id: 216432:CA2559_RS04550
uniprot id: A3U6X8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS07780
gene id: 216432:CA2559_RS07780
uniprot id: A3UBD1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

216432:CA2559 RS03160
gene id: 216432:CA2559_RS03160
uniprot id: A3U652
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

216432:CA2559 RS01515
gene id: 216432:CA2559_RS01515
uniprot id: A3U571
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

216432:CA2559 RS09375
gene id: 216432:CA2559_RS09375
uniprot id: A3U8X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

216432:CA2559 RS02455
gene id: 216432:CA2559_RS02455
uniprot id: A3U5R0
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

216432:CA2559 RS03800
gene id: 216432:CA2559_RS03800
uniprot id: A3U6H9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

216432:CA2559 RS12495
gene id: 216432:CA2559_RS12495
uniprot id: A3UAQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

216432:CA2559 RS04200
gene id: 216432:CA2559_RS04200
uniprot id: A3U6Q8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

216432:CA2559 RS05845
gene id: 216432:CA2559_RS05845
uniprot id: A3U7N6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

216432:CA2559 RS13090
gene id: 216432:CA2559_RS13090
uniprot id: A3UB27
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

216432:CA2559 RS01655
gene id: 216432:CA2559_RS01655
uniprot id: A3U599
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

216432:CA2559 RS10825
gene id: 216432:CA2559_RS10825
uniprot id: A3U9R3
names: Similarity
messages: Belongs to the SUI1 family.

216432:CA2559 RS11275
gene id: 216432:CA2559_RS11275
uniprot id: A3UA05
names: Similarity
names: Subunit
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family. SbnA subfamily.
messages: Homodimer.

216432:CA2559 RS05705
gene id: 216432:CA2559_RS05705
uniprot id: A3U7K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

216432:CA2559 RS07800
gene id: 216432:CA2559_RS07800
uniprot id: A3UBD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

216432:CA2559 RS11010
gene id: 216432:CA2559_RS11010
uniprot id: A3U9V2
names: Similarity
messages: Belongs to the ClpA/ClpB family.

216432:CA2559 RS08860
gene id: 216432:CA2559_RS08860
uniprot id: A3UC00
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

216432:CA2559 RS06755
gene id: 216432:CA2559_RS06755
uniprot id: A3U872
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

216432:CA2559 RS13445
gene id: 216432:CA2559_RS13445
uniprot id: A3UB99
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

216432:CA2559 RS12740
gene id: 216432:CA2559_RS12740
uniprot id: A3UAV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

216432:CA2559 RS06680
gene id: 216432:CA2559_RS06680
uniprot id: A3U857
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

216432:CA2559 RS00520
gene id: 216432:CA2559_RS00520
uniprot id: A3U4M5
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

216432:CA2559 RS01180
gene id: 216432:CA2559_RS01180
uniprot id: A3U504
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS07770
gene id: 216432:CA2559_RS07770
uniprot id: A3UBC9
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

216432:CA2559 RS11950
gene id: 216432:CA2559_RS11950
uniprot id: A3UAE5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

216432:CA2559 RS09355
gene id: 216432:CA2559_RS09355
uniprot id: A3U8W6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

216432:CA2559 RS00715
gene id: 216432:CA2559_RS00715
uniprot id: A3U4R5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

216432:CA2559 RS03645
gene id: 216432:CA2559_RS03645
uniprot id: A3U6E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.

216432:CA2559 RS00670
gene id: 216432:CA2559_RS00670
uniprot id: A3U4Q6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

216432:CA2559 RS08660
gene id: 216432:CA2559_RS08660
uniprot id: A3UBV8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

216432:CA2559 RS12930
gene id: 216432:CA2559_RS12930
uniprot id: A3UAZ4
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

216432:CA2559 RS08490
gene id: 216432:CA2559_RS08490
uniprot id: A3UBS4
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

216432:CA2559 RS10845
gene id: 216432:CA2559_RS10845
uniprot id: A3U9R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

216432:CA2559 RS11805
gene id: 216432:CA2559_RS11805
uniprot id: A3UAB4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

216432:CA2559 RS02855
gene id: 216432:CA2559_RS02855
uniprot id: A3U5Z0
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

216432:CA2559 RS03320
gene id: 216432:CA2559_RS03320
uniprot id: A3U684
names: Similarity
messages: Belongs to the transglycosylase Slt family.

216432:CA2559 RS04995
gene id: 216432:CA2559_RS04995
uniprot id: A3U766
names: Similarity
messages: Belongs to the group II decarboxylase family.

216432:CA2559 RS01290
gene id: 216432:CA2559_RS01290
uniprot id: A3U526
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

216432:CA2559 RS10055
gene id: 216432:CA2559_RS10055
uniprot id: A3U9A5
names: Subcellular Location Annotation
messages: Membrane

216432:CA2559 RS05510
gene id: 216432:CA2559_RS05510
uniprot id: A3U7G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

216432:CA2559 RS08945
gene id: 216432:CA2559_RS08945
uniprot id: A3UC17
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

216432:CA2559 RS11995
gene id: 216432:CA2559_RS11995
uniprot id: A3UAF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

216432:CA2559 RS09405
gene id: 216432:CA2559_RS09405
uniprot id: A3U8X6
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

216432:CA2559 RS06635
gene id: 216432:CA2559_RS06635
uniprot id: A3U848
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

216432:CA2559 RS12135
gene id: 216432:CA2559_RS12135
uniprot id: A3UAI3
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

216432:CA2559 RS04880
gene id: 216432:CA2559_RS04880
uniprot id: A3U744
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

216432:CA2559 RS00020
gene id: 216432:CA2559_RS00020
uniprot id: A3U4C6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

216432:CA2559 RS02845
gene id: 216432:CA2559_RS02845
uniprot id: A3U5Y8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

216432:CA2559 RS07140
gene id: 216432:CA2559_RS07140
uniprot id: A3U8F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

216432:CA2559 RS05730
gene id: 216432:CA2559_RS05730
uniprot id: A3U7L2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

216432:CA2559 RS00025
gene id: 216432:CA2559_RS00025
uniprot id: A3U4C7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

216432:CA2559 RS09970
gene id: 216432:CA2559_RS09970
uniprot id: A3U985
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

216432:CA2559 RS05380
gene id: 216432:CA2559_RS05380
uniprot id: A3U7E2
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

216432:CA2559 RS04370
gene id: 216432:CA2559_RS04370
uniprot id: A3U6U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

216432:CA2559 RS10820
gene id: 216432:CA2559_RS10820
uniprot id: A3U9R2
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

216432:CA2559 RS03150
gene id: 216432:CA2559_RS03150
uniprot id: A3U650
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

216432:CA2559 RS05540
gene id: 216432:CA2559_RS05540
uniprot id: A3U7H4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

216432:CA2559 RS02415
gene id: 216432:CA2559_RS02415
uniprot id: A3U5Q2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS10610
gene id: 216432:CA2559_RS10610
uniprot id: A3U9L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

216432:CA2559 RS08010
gene id: 216432:CA2559_RS08010
uniprot id: A3UBH8
names: Similarity
messages: Belongs to the peptidase S9A family.

216432:CA2559 RS09045
gene id: 216432:CA2559_RS09045
uniprot id: A3UC37
names: Similarity
messages: Belongs to the OsmC/Ohr family.

216432:CA2559 RS12945
gene id: 216432:CA2559_RS12945
uniprot id: A3UAZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

216432:CA2559 RS01225
gene id: 216432:CA2559_RS01225
uniprot id: A3U513
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

216432:CA2559 RS02515
gene id: 216432:CA2559_RS02515
uniprot id: A3U5S2
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

216432:CA2559 RS05770
gene id: 216432:CA2559_RS05770
uniprot id: A3U7M0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

216432:CA2559 RS08380
gene id: 216432:CA2559_RS08380
uniprot id: A3UBQ2
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

216432:CA2559 RS05960
gene id: 216432:CA2559_RS05960
uniprot id: A3U7R0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell inner membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

216432:CA2559 RS05550
gene id: 216432:CA2559_RS05550
uniprot id: A3U7H8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

216432:CA2559 RS11615
gene id: 216432:CA2559_RS11615
uniprot id: A3UA77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

216432:CA2559 RS08940
gene id: 216432:CA2559_RS08940
uniprot id: A3UC16
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm