2133:SCITRI RS01615
gene id: 2133:SCITRI_RS01615
uniprot id: A0A1J0YZ26
uniprot id: O31165
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

2133:SCITRI RS01655
gene id: 2133:SCITRI_RS01655
uniprot id: Q14PJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

2133:SCITRI RS02195
gene id: 2133:SCITRI_RS02195
uniprot id: Q6XK15
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

2133:SCITRI RS05390
gene id: 2133:SCITRI_RS05390
uniprot id: Q14NJ6
names: Similarity
messages: Belongs to the pyruvate kinase family.

2133:SCITRI RS01085
gene id: 2133:SCITRI_RS01085
uniprot id: A0A1J0YZ29
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS07125
gene id: 2133:SCITRI_RS07125
uniprot id: A0A1J0Z2I5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

2133:SCITRI RS09065
gene id: 2133:SCITRI_RS09065
uniprot id: A0A1J0Z3M8
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS02230
gene id: 2133:SCITRI_RS02230
uniprot id: A0A1J0YZE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

2133:SCITRI RS08790
gene id: 2133:SCITRI_RS08790
uniprot id: A0A1J0Z454
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

2133:SCITRI RS02120
gene id: 2133:SCITRI_RS02120
uniprot id: A0A1J0YZC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

2133:SCITRI RS00090
gene id: 2133:SCITRI_RS00090
uniprot id: Q14QG4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

2133:SCITRI RS00440
gene id: 2133:SCITRI_RS00440
uniprot id: Q14QA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

2133:SCITRI RS06185
gene id: 2133:SCITRI_RS06185
uniprot id: A0A5B8XN41
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

2133:SCITRI RS00790
gene id: 2133:SCITRI_RS00790
uniprot id: Q14Q05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2133:SCITRI RS01880
gene id: 2133:SCITRI_RS01880
uniprot id: A0A1J0Z020
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

2133:SCITRI RS07420
gene id: 2133:SCITRI_RS07420
uniprot id: Q14LU1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

2133:SCITRI RS00825
gene id: 2133:SCITRI_RS00825
uniprot id: A0A1J0YZF5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

2133:SCITRI RS08200
gene id: 2133:SCITRI_RS08200
uniprot id: Q14LC1
uniprot id: Q53844
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

2133:SCITRI RS00705
gene id: 2133:SCITRI_RS00705
uniprot id: Q14Q23
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

2133:SCITRI RS04015
gene id: 2133:SCITRI_RS04015
uniprot id: Q14LZ0
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Homodimer.

2133:SCITRI RS05020
gene id: 2133:SCITRI_RS05020
uniprot id: A0A1J0Z217
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

2133:SCITRI RS00765
gene id: 2133:SCITRI_RS00765
uniprot id: A0A1J0YYL2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

2133:SCITRI RS02100
gene id: 2133:SCITRI_RS02100
uniprot id: Q14PA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

2133:SCITRI RS04785
gene id: 2133:SCITRI_RS04785
uniprot id: A0A5B8XIF5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

2133:SCITRI RS01275
gene id: 2133:SCITRI_RS01275
uniprot id: A0A1J0YYW3
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

2133:SCITRI RS08035
gene id: 2133:SCITRI_RS08035
uniprot id: A0A1J0Z3I0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS07980
gene id: 2133:SCITRI_RS07980
uniprot id: A0A1J0Z2V6
names: Similarity
messages: Belongs to the UPF0236 family.

2133:SCITRI RS03340
gene id: 2133:SCITRI_RS03340
uniprot id: Q14M71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

2133:SCITRI RS02265
gene id: 2133:SCITRI_RS02265
uniprot id: A0A1J0YZF0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

2133:SCITRI RS07740
gene id: 2133:SCITRI_RS07740
uniprot id: A0A1J0Z2L4
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

2133:SCITRI RS03750
gene id: 2133:SCITRI_RS03750
uniprot id: A0A1J0Z0B8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

2133:SCITRI RS01670
gene id: 2133:SCITRI_RS01670
uniprot id: A0A1J0Z028
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

2133:SCITRI RS09250
gene id: 2133:SCITRI_RS09250
uniprot id: A0A1J0Z3M5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS00065
gene id: 2133:SCITRI_RS00065
uniprot id: Q14QH0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

2133:SCITRI RS02500
gene id: 2133:SCITRI_RS02500
uniprot id: A0A5B8XK38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

2133:SCITRI RS01810
gene id: 2133:SCITRI_RS01810
uniprot id: A0A1J0YZ57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

2133:SCITRI RS04440
gene id: 2133:SCITRI_RS04440
uniprot id: A0A1J0Z0N4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

2133:SCITRI RS06405
gene id: 2133:SCITRI_RS06405
uniprot id: Q14NX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

2133:SCITRI RS01235
gene id: 2133:SCITRI_RS01235
uniprot id: A0A1J0YYV5
names: Similarity
messages: Belongs to the ParB family.

2133:SCITRI RS02800
gene id: 2133:SCITRI_RS02800
uniprot id: A0A1J0YZQ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS02820
gene id: 2133:SCITRI_RS02820
uniprot id: Q14LP2
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

2133:SCITRI RS03920
gene id: 2133:SCITRI_RS03920
uniprot id: Q14MH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Heptamer of 7 subunits arranged in a ring.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

2133:SCITRI RS00685
gene id: 2133:SCITRI_RS00685
uniprot id: Q14Q27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

2133:SCITRI RS07380
gene id: 2133:SCITRI_RS07380
uniprot id: Q14LV0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

2133:SCITRI RS04125
gene id: 2133:SCITRI_RS04125
uniprot id: Q14KG9
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Homodimer.

2133:SCITRI RS01565
gene id: 2133:SCITRI_RS01565
uniprot id: A0A1J0YZ17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

2133:SCITRI RS08800
gene id: 2133:SCITRI_RS08800
uniprot id: A0A1J0Z3Y4
names: Similarity
messages: Belongs to the UPF0236 family.

2133:SCITRI RS05940
gene id: 2133:SCITRI_RS05940
uniprot id: Q14NN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

2133:SCITRI RS03470
gene id: 2133:SCITRI_RS03470
uniprot id: A0A1J0Z136
names: Similarity
messages: Belongs to the UPF0236 family.

2133:SCITRI RS08135
gene id: 2133:SCITRI_RS08135
uniprot id: A0A1J0Z2P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

2133:SCITRI RS09140
gene id: 2133:SCITRI_RS09140
uniprot id: Q14QM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

2133:SCITRI RS01830
gene id: 2133:SCITRI_RS01830
uniprot id: A0A1J0Z060
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

2133:SCITRI RS06155
gene id: 2133:SCITRI_RS06155
uniprot id: Q14NR8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

2133:SCITRI RS03075
gene id: 2133:SCITRI_RS03075
uniprot id: A0A1J0Z054
names: Similarity
messages: Belongs to the UPF0236 family.

2133:SCITRI RS01795
gene id: 2133:SCITRI_RS01795
uniprot id: Q14PG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

2133:SCITRI RS04005
gene id: 2133:SCITRI_RS04005
uniprot id: Q14LY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

2133:SCITRI RS01055
gene id: 2133:SCITRI_RS01055
uniprot id: Q14PU3
names: Similarity
messages: Belongs to the HPrK/P family.

2133:SCITRI RS02210
gene id: 2133:SCITRI_RS02210
uniprot id: A0A1J0YZM4
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS01060
gene id: 2133:SCITRI_RS01060
uniprot id: Q14PU2
names: Similarity
messages: Belongs to the Lgt family.

2133:SCITRI RS02805
gene id: 2133:SCITRI_RS02805
uniprot id: A0A1J0YZQ4
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

2133:SCITRI RS00680
gene id: 2133:SCITRI_RS00680
uniprot id: Q14Q28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

2133:SCITRI RS05440
gene id: 2133:SCITRI_RS05440
uniprot id: Q14NK6
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

2133:SCITRI RS05015
gene id: 2133:SCITRI_RS05015
uniprot id: Q14NC9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS01690
gene id: 2133:SCITRI_RS01690
uniprot id: A0A1J0YZ40
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

2133:SCITRI RS08050
gene id: 2133:SCITRI_RS08050
uniprot id: Q14LJ0
names: Similarity
messages: Belongs to the thioredoxin family.

2133:SCITRI RS06375
gene id: 2133:SCITRI_RS06375
uniprot id: A0A5B8XHK8
uniprot id: Q14NW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

2133:SCITRI RS07425
gene id: 2133:SCITRI_RS07425
uniprot id: A0A1J0Z2Q1
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

2133:SCITRI RS01260
gene id: 2133:SCITRI_RS01260
uniprot id: A0A1J0YZQ9
names: Similarity
messages: Belongs to the RpoE family.

2133:SCITRI RS05520
gene id: 2133:SCITRI_RS05520
uniprot id: Q14NM2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

2133:SCITRI RS04435
gene id: 2133:SCITRI_RS04435
uniprot id: A0A1J0Z1G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

2133:SCITRI RS06100
gene id: 2133:SCITRI_RS06100
uniprot id: Q14NQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

2133:SCITRI RS01270
gene id: 2133:SCITRI_RS01270
uniprot id: Q14PP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

2133:SCITRI RS07040
gene id: 2133:SCITRI_RS07040
uniprot id: A0A1J0Z2H0
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

2133:SCITRI RS07465
gene id: 2133:SCITRI_RS07465
uniprot id: A0A1J0Z2R0
names: Similarity
messages: Belongs to the UPF0236 family.

2133:SCITRI RS06275
gene id: 2133:SCITRI_RS06275
uniprot id: Q14NU6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS08235
gene id: 2133:SCITRI_RS08235
uniprot id: Q14LB4
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

2133:SCITRI RS00260
gene id: 2133:SCITRI_RS00260
uniprot id: Q14QE3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

2133:SCITRI RS03400
gene id: 2133:SCITRI_RS03400
uniprot id: A0A1J0Z0D8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2133:SCITRI RS06255
gene id: 2133:SCITRI_RS06255
uniprot id: Q14NU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

2133:SCITRI RS02290
gene id: 2133:SCITRI_RS02290
uniprot id: Q14P63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

2133:SCITRI RS04510
gene id: 2133:SCITRI_RS04510
uniprot id: A0A5B8XGR8
names: Similarity
messages: Belongs to the TlyA family.

2133:SCITRI RS02285
gene id: 2133:SCITRI_RS02285
uniprot id: A0A5B8XNE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

2133:SCITRI RS01095
gene id: 2133:SCITRI_RS01095
uniprot id: A0A1J0YYR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

2133:SCITRI RS01680
gene id: 2133:SCITRI_RS01680
uniprot id: Q14PI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

2133:SCITRI RS02275
gene id: 2133:SCITRI_RS02275
uniprot id: A0A1J0YZP0
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS01175
gene id: 2133:SCITRI_RS01175
uniprot id: Q14PR7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

2133:SCITRI RS07570
gene id: 2133:SCITRI_RS07570
uniprot id: Q14LS1
names: Similarity
messages: Belongs to the asp23 family.

2133:SCITRI RS05515
gene id: 2133:SCITRI_RS05515
uniprot id: A0A1J0Z1B6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

2133:SCITRI RS08885
gene id: 2133:SCITRI_RS08885
uniprot id: A0A1J0Z369
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

2133:SCITRI RS06470
gene id: 2133:SCITRI_RS06470
uniprot id: Q14NX4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

2133:SCITRI RS02405
gene id: 2133:SCITRI_RS02405
uniprot id: Q14P39
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

2133:SCITRI RS00595
gene id: 2133:SCITRI_RS00595
uniprot id: Q14Q85
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

2133:SCITRI RS09240
gene id: 2133:SCITRI_RS09240
uniprot id: Q8VQG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

2133:SCITRI RS01165
gene id: 2133:SCITRI_RS01165
uniprot id: Q14PR9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

2133:SCITRI RS00695
gene id: 2133:SCITRI_RS00695
uniprot id: Q14Q25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

2133:SCITRI RS02700
gene id: 2133:SCITRI_RS02700
uniprot id: Q14LW2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

2133:SCITRI RS08205
gene id: 2133:SCITRI_RS08205
uniprot id: Q14LC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

2133:SCITRI RS03780
gene id: 2133:SCITRI_RS03780
uniprot id: A0A1J0Z0C2
names: Similarity
messages: Belongs to the UPF0236 family.

2133:SCITRI RS02590
gene id: 2133:SCITRI_RS02590
uniprot id: Q8VP64
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS05535
gene id: 2133:SCITRI_RS05535
uniprot id: A0A1J0Z2B7
names: Similarity
messages: Belongs to the UPF0236 family.

2133:SCITRI RS08240
gene id: 2133:SCITRI_RS08240
uniprot id: Q14LB3
names: Similarity
messages: Belongs to the ClpA/ClpB family.

2133:SCITRI RS01540
gene id: 2133:SCITRI_RS01540
uniprot id: A0A1J0YZB3
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

2133:SCITRI RS04935
gene id: 2133:SCITRI_RS04935
uniprot id: Q14NB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0154 family.
messages: Membrane

2133:SCITRI RS03490
gene id: 2133:SCITRI_RS03490
uniprot id: Q14L65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

2133:SCITRI RS01950
gene id: 2133:SCITRI_RS01950
uniprot id: Q14PD6
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

2133:SCITRI RS05395
gene id: 2133:SCITRI_RS05395
uniprot id: P20275
uniprot id: Q14NJ7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS05480
gene id: 2133:SCITRI_RS05480
uniprot id: A0A1J0Z1J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

2133:SCITRI RS05850
gene id: 2133:SCITRI_RS05850
uniprot id: A0A1J0Z1H2
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

2133:SCITRI RS01735
gene id: 2133:SCITRI_RS01735
uniprot id: A0A1J0YZ50
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

2133:SCITRI RS08680
gene id: 2133:SCITRI_RS08680
uniprot id: Q14L25
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

2133:SCITRI RS01630
gene id: 2133:SCITRI_RS01630
uniprot id: A0A1J0Z017
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

2133:SCITRI RS01280
gene id: 2133:SCITRI_RS01280
uniprot id: Q14PP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

2133:SCITRI RS01240
gene id: 2133:SCITRI_RS01240
uniprot id: A0A1J0YZ39
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

2133:SCITRI RS06475
gene id: 2133:SCITRI_RS06475
uniprot id: Q14NX5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

2133:SCITRI RS00700
gene id: 2133:SCITRI_RS00700
uniprot id: Q14Q24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

2133:SCITRI RS10720
gene id: 2133:SCITRI_RS10720
uniprot id: A0A1J0Z0U5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

2133:SCITRI RS01910
gene id: 2133:SCITRI_RS01910
uniprot id: Q14PE4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

2133:SCITRI RS02530
gene id: 2133:SCITRI_RS02530
uniprot id: Q14P10
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

2133:SCITRI RS01510
gene id: 2133:SCITRI_RS01510
uniprot id: Q14PM1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS01560
gene id: 2133:SCITRI_RS01560
uniprot id: Q14PL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

2133:SCITRI RS06265
gene id: 2133:SCITRI_RS06265
uniprot id: Q14NU4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

2133:SCITRI RS06480
gene id: 2133:SCITRI_RS06480
uniprot id: Q14NX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

2133:SCITRI RS00105
gene id: 2133:SCITRI_RS00105
uniprot id: Q14QG1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

2133:SCITRI RS03045
gene id: 2133:SCITRI_RS03045
uniprot id: A0A1J0Z065
names: Similarity
messages: Belongs to the UPF0236 family.

2133:SCITRI RS00230
gene id: 2133:SCITRI_RS00230
uniprot id: A0A1J0YYH5
names: Similarity
messages: Belongs to the UPF0236 family.

2133:SCITRI RS01125
gene id: 2133:SCITRI_RS01125
uniprot id: A0A1J0YYS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

2133:SCITRI RS08510
gene id: 2133:SCITRI_RS08510
uniprot id: Q14Q59
names: Similarity
messages: Belongs to the Fur family.

2133:SCITRI RS00435
gene id: 2133:SCITRI_RS00435
uniprot id: Q14QA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

2133:SCITRI RS08020
gene id: 2133:SCITRI_RS08020
uniprot id: A0A1J0Z308
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS01825
gene id: 2133:SCITRI_RS01825
uniprot id: Q14PF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

2133:SCITRI RS01720
gene id: 2133:SCITRI_RS01720
uniprot id: Q14PI1
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS01250
gene id: 2133:SCITRI_RS01250
uniprot id: A0A1J0YZW5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

2133:SCITRI RS02320
gene id: 2133:SCITRI_RS02320
uniprot id: Q14P57
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

2133:SCITRI RS01435
gene id: 2133:SCITRI_RS01435
uniprot id: Q462Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

2133:SCITRI RS03495
gene id: 2133:SCITRI_RS03495
uniprot id: Q14L64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

2133:SCITRI RS06260
gene id: 2133:SCITRI_RS06260
uniprot id: A0A1J0Z1Y0
names: Similarity
messages: Belongs to the ribF family.

2133:SCITRI RS00640
gene id: 2133:SCITRI_RS00640
uniprot id: Q14Q74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

2133:SCITRI RS09225
gene id: 2133:SCITRI_RS09225
uniprot id: A0A1J0Z3C7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS03065
gene id: 2133:SCITRI_RS03065
uniprot id: A0A1J0YZW1
names: Similarity
messages: Belongs to the RutC family.

2133:SCITRI RS08230
gene id: 2133:SCITRI_RS08230
uniprot id: Q14LB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

2133:SCITRI RS08655
gene id: 2133:SCITRI_RS08655
uniprot id: Q6XK09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

2133:SCITRI RS01205
gene id: 2133:SCITRI_RS01205
uniprot id: A0A1J0YZ48
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

2133:SCITRI RS07155
gene id: 2133:SCITRI_RS07155
uniprot id: Q14MP3
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

2133:SCITRI RS07620
gene id: 2133:SCITRI_RS07620
uniprot id: A0A1J0Z2S4
uniprot id: Q6XK03
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

2133:SCITRI RS01505
gene id: 2133:SCITRI_RS01505
uniprot id: Q14PM2
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS01755
gene id: 2133:SCITRI_RS01755
uniprot id: Q14PH2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

2133:SCITRI RS01580
gene id: 2133:SCITRI_RS01580
uniprot id: Q14PK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

2133:SCITRI RS00315
gene id: 2133:SCITRI_RS00315
uniprot id: A0A1J0YYL7
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS03370
gene id: 2133:SCITRI_RS03370
uniprot id: Q14M79
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

2133:SCITRI RS06760
gene id: 2133:SCITRI_RS06760
uniprot id: Q14KE3
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS08210
gene id: 2133:SCITRI_RS08210
uniprot id: A0A1J0Z3S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

2133:SCITRI RS02460
gene id: 2133:SCITRI_RS02460
uniprot id: A0A1J0YZK4
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

2133:SCITRI RS01445
gene id: 2133:SCITRI_RS01445
uniprot id: A0A1J0YYZ5
names: Similarity
messages: Belongs to the carbamate kinase family.

2133:SCITRI RS01625
gene id: 2133:SCITRI_RS01625
uniprot id: Q14PK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

2133:SCITRI RS04000
gene id: 2133:SCITRI_RS04000
uniprot id: A0A1J0Z0R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

2133:SCITRI RS01730
gene id: 2133:SCITRI_RS01730
uniprot id: Q14PH9
names: Subcellular Location Annotation
messages: Cytoplasm

2133:SCITRI RS08905
gene id: 2133:SCITRI_RS08905
uniprot id: Q14KZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

2133:SCITRI RS05495
gene id: 2133:SCITRI_RS05495
uniprot id: A0A5B8XH98
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

2133:SCITRI RS00445
gene id: 2133:SCITRI_RS00445
uniprot id: Q14QA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

2133:SCITRI RS01285
gene id: 2133:SCITRI_RS01285
uniprot id: Q14PP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

2133:SCITRI RS09210
gene id: 2133:SCITRI_RS09210
uniprot id: Q14QK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

2133:SCITRI RS02765
gene id: 2133:SCITRI_RS02765
uniprot id: A0A1J0Z011
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS05500
gene id: 2133:SCITRI_RS05500
uniprot id: Q14NL8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

2133:SCITRI RS07035
gene id: 2133:SCITRI_RS07035
uniprot id: Q14MS2
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS01590
gene id: 2133:SCITRI_RS01590
uniprot id: Q14PK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

2133:SCITRI RS05220
gene id: 2133:SCITRI_RS05220
uniprot id: A0A1J0Z179
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

2133:SCITRI RS02300
gene id: 2133:SCITRI_RS02300
uniprot id: Q14P61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

2133:SCITRI RS08225
gene id: 2133:SCITRI_RS08225
uniprot id: Q14LB6
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

2133:SCITRI RS00320
gene id: 2133:SCITRI_RS00320
uniprot id: A0A1J0YZC0
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS00730
gene id: 2133:SCITRI_RS00730
uniprot id: Q14Q18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

2133:SCITRI RS05400
gene id: 2133:SCITRI_RS05400
uniprot id: P19215
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spiralin family.
messages: Cell membrane
messages: Major membrane protein of spiroplasma.
messages: Palmitate and stearate are the major lipid components.
messages: Seems to occur as dimer, tetramers, and large oligomers of identical chains.

2133:SCITRI RS08805
gene id: 2133:SCITRI_RS08805
uniprot id: A0A1J0Z354
names: Similarity
messages: Belongs to the UPF0236 family.

2133:SCITRI RS09215
gene id: 2133:SCITRI_RS09215
uniprot id: Q14QK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease M5 family.
messages: Cytoplasm
messages: Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.

2133:SCITRI RS00040
gene id: 2133:SCITRI_RS00040
uniprot id: A0A1J0YY43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

2133:SCITRI RS01640
gene id: 2133:SCITRI_RS01640
uniprot id: A0A1J0YZX6
uniprot id: Q14PJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

2133:SCITRI RS00750
gene id: 2133:SCITRI_RS00750
uniprot id: Q14Q13
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

2133:SCITRI RS05490
gene id: 2133:SCITRI_RS05490
uniprot id: Q14NL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

2133:SCITRI RS00130
gene id: 2133:SCITRI_RS00130
uniprot id: A0A1J0YZ07
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS01665
gene id: 2133:SCITRI_RS01665
uniprot id: Q14PJ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

2133:SCITRI RS08220
gene id: 2133:SCITRI_RS08220
uniprot id: A0A1J0Z3K8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

2133:SCITRI RS02950
gene id: 2133:SCITRI_RS02950
uniprot id: A0A6I7GYR1
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS10935
gene id: 2133:SCITRI_RS10935
uniprot id: Q14Q90
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

2133:SCITRI RS01050
gene id: 2133:SCITRI_RS01050
uniprot id: Q14PU4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

2133:SCITRI RS04800
gene id: 2133:SCITRI_RS04800
uniprot id: A0A1J0Z0X9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

2133:SCITRI RS01935
gene id: 2133:SCITRI_RS01935
uniprot id: Q14PD9
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

2133:SCITRI RS01225
gene id: 2133:SCITRI_RS01225
uniprot id: Q14PQ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

2133:SCITRI RS01695
gene id: 2133:SCITRI_RS01695
uniprot id: Q14PI6
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

2133:SCITRI RS02270
gene id: 2133:SCITRI_RS02270
uniprot id: Q14P67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

2133:SCITRI RS07260
gene id: 2133:SCITRI_RS07260
uniprot id: A0A1J0Z2L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

2133:SCITRI RS01600
gene id: 2133:SCITRI_RS01600
uniprot id: O31162
uniprot id: Q14PK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

2133:SCITRI RS00930
gene id: 2133:SCITRI_RS00930
uniprot id: Q14PY0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

2133:SCITRI RS00070
gene id: 2133:SCITRI_RS00070
uniprot id: A0A1J0YY42
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

2133:SCITRI RS04375
gene id: 2133:SCITRI_RS04375
uniprot id: A0A1J0Z0V9
names: Similarity
messages: Belongs to the UPF0236 family.

2133:SCITRI RS08610
gene id: 2133:SCITRI_RS08610
uniprot id: A0A1J0Z3C8
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS06160
gene id: 2133:SCITRI_RS06160
uniprot id: Q14NR9
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS02040
gene id: 2133:SCITRI_RS02040
uniprot id: Q14PB9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

2133:SCITRI RS07770
gene id: 2133:SCITRI_RS07770
uniprot id: Q14LK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

2133:SCITRI RS07765
gene id: 2133:SCITRI_RS07765
uniprot id: Q14LK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

2133:SCITRI RS02125
gene id: 2133:SCITRI_RS02125
uniprot id: Q14PA0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

2133:SCITRI RS01595
gene id: 2133:SCITRI_RS01595
uniprot id: A0A1J0YZ04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

2133:SCITRI RS04895
gene id: 2133:SCITRI_RS04895
uniprot id: Q14N99
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

2133:SCITRI RS08305
gene id: 2133:SCITRI_RS08305
uniprot id: A0A1J0Z2V8
names: Similarity
messages: Belongs to the peptidase M17 family.

2133:SCITRI RS05770
gene id: 2133:SCITRI_RS05770
uniprot id: A0A1J0Z2G5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

2133:SCITRI RS07235
gene id: 2133:SCITRI_RS07235
uniprot id: Q14ML4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

2133:SCITRI RS01155
gene id: 2133:SCITRI_RS01155
uniprot id: Q14PS1
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

2133:SCITRI RS01170
gene id: 2133:SCITRI_RS01170
uniprot id: A0A1J0YZP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

2133:SCITRI RS08950
gene id: 2133:SCITRI_RS08950
uniprot id: A0A1J0Z486
names: Similarity
messages: Belongs to the UPF0236 family.

2133:SCITRI RS00420
gene id: 2133:SCITRI_RS00420
uniprot id: A0A1J0YYL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

2133:SCITRI RS01195
gene id: 2133:SCITRI_RS01195
uniprot id: A0A5B8XJL7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

2133:SCITRI RS02760
gene id: 2133:SCITRI_RS02760
uniprot id: Q14LW7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

2133:SCITRI RS07400
gene id: 2133:SCITRI_RS07400
uniprot id: A0A1J0Z380
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

2133:SCITRI RS01490
gene id: 2133:SCITRI_RS01490
uniprot id: Q14PM5
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.

2133:SCITRI RS00900
gene id: 2133:SCITRI_RS00900
uniprot id: A0A1J0YYN8
names: Similarity
messages: Belongs to the UPF0236 family.

2133:SCITRI RS03310
gene id: 2133:SCITRI_RS03310
uniprot id: Q14M65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2133:SCITRI RS01945
gene id: 2133:SCITRI_RS01945
uniprot id: Q14PD7
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

2133:SCITRI RS01585
gene id: 2133:SCITRI_RS01585
uniprot id: Q14PK8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

2133:SCITRI RS04425
gene id: 2133:SCITRI_RS04425
uniprot id: Q53854
names: Similarity
messages: Belongs to the RecA family.

2133:SCITRI RS05415
gene id: 2133:SCITRI_RS05415
uniprot id: A0A1J0Z168
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

2133:SCITRI RS06300
gene id: 2133:SCITRI_RS06300
uniprot id: A0A1J0Z1Y7
uniprot id: Q14NV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

2133:SCITRI RS02465
gene id: 2133:SCITRI_RS02465
uniprot id: A0A1J0YZS6
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

2133:SCITRI RS03565
gene id: 2133:SCITRI_RS03565
uniprot id: Q14MC4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

2133:SCITRI RS02105
gene id: 2133:SCITRI_RS02105
uniprot id: A0A1J0Z0B6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

2133:SCITRI RS01685
gene id: 2133:SCITRI_RS01685
uniprot id: Q14PI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

2133:SCITRI RS02245
gene id: 2133:SCITRI_RS02245
uniprot id: A0A1J0YZN2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

2133:SCITRI RS00005
gene id: 2133:SCITRI_RS00005
uniprot id: A0A1J0YY53
uniprot id: P34028
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

2133:SCITRI RS01570
gene id: 2133:SCITRI_RS01570
uniprot id: Q14PL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

2133:SCITRI RS09220
gene id: 2133:SCITRI_RS09220
uniprot id: A0A1J0Z4E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

2133:SCITRI RS03315
gene id: 2133:SCITRI_RS03315
uniprot id: A0A1J0Z0A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2133:SCITRI RS07455
gene id: 2133:SCITRI_RS07455
uniprot id: A0A1J0Z2E5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

2133:SCITRI RS08915
gene id: 2133:SCITRI_RS08915
uniprot id: A0A1J0Z360
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

2133:SCITRI RS00745
gene id: 2133:SCITRI_RS00745
uniprot id: Q14Q14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

2133:SCITRI RS01815
gene id: 2133:SCITRI_RS01815
uniprot id: A0A1J0YZ68
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

2133:SCITRI RS00270
gene id: 2133:SCITRI_RS00270
uniprot id: A0A1J0YYI1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

2133:SCITRI RS02225
gene id: 2133:SCITRI_RS02225
uniprot id: A0A1J0Z088
names: Similarity
messages: Belongs to the Lgt family.

2133:SCITRI RS01660
gene id: 2133:SCITRI_RS01660
uniprot id: Q14PJ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

2133:SCITRI RS08650
gene id: 2133:SCITRI_RS08650
uniprot id: A0A1J0Z3D7
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS01475
gene id: 2133:SCITRI_RS01475
uniprot id: Q14PM8
names: Similarity
messages: Belongs to the GPI family.

2133:SCITRI RS06280
gene id: 2133:SCITRI_RS06280
uniprot id: A0A1J0Z2J5
names: Function
names: Similarity
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.

2133:SCITRI RS03995
gene id: 2133:SCITRI_RS03995
uniprot id: A0A1J0Z0N7
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS08675
gene id: 2133:SCITRI_RS08675
uniprot id: Q14L26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

2133:SCITRI RS08620
gene id: 2133:SCITRI_RS08620
uniprot id: Q14L40
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

2133:SCITRI RS01245
gene id: 2133:SCITRI_RS01245
uniprot id: Q14PQ0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS08815
gene id: 2133:SCITRI_RS08815
uniprot id: Q14L13
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

2133:SCITRI RS07140
gene id: 2133:SCITRI_RS07140
uniprot id: Q14MP6
names: Subcellular Location Annotation
messages: Cytoplasm

2133:SCITRI RS03410
gene id: 2133:SCITRI_RS03410
uniprot id: Q14M87
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

2133:SCITRI RS02535
gene id: 2133:SCITRI_RS02535
uniprot id: Q14P09
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

2133:SCITRI RS09235
gene id: 2133:SCITRI_RS09235
uniprot id: Q14QJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

2133:SCITRI RS01620
gene id: 2133:SCITRI_RS01620
uniprot id: Q14PK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

2133:SCITRI RS05460
gene id: 2133:SCITRI_RS05460
uniprot id: A0A1J0Z244
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

2133:SCITRI RS02280
gene id: 2133:SCITRI_RS02280
uniprot id: A0A1J0YZR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

2133:SCITRI RS03740
gene id: 2133:SCITRI_RS03740
uniprot id: A0A1J0Z098
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

2133:SCITRI RS04320
gene id: 2133:SCITRI_RS04320
uniprot id: A0A1J0Z0N0
names: Similarity
messages: Belongs to the DNA photolyase family.

2133:SCITRI RS08895
gene id: 2133:SCITRI_RS08895
uniprot id: Q14KZ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS02305
gene id: 2133:SCITRI_RS02305
uniprot id: A0A1J0YZH8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

2133:SCITRI RS00385
gene id: 2133:SCITRI_RS00385
uniprot id: A0A1J0YYB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

2133:SCITRI RS07995
gene id: 2133:SCITRI_RS07995
uniprot id: A0A1J0Z3M9
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS00690
gene id: 2133:SCITRI_RS00690
uniprot id: Q14Q26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

2133:SCITRI RS02255
gene id: 2133:SCITRI_RS02255
uniprot id: Q14P70
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS09300
gene id: 2133:SCITRI_RS09300
uniprot id: A0A1J0Z3E2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

2133:SCITRI RS07445
gene id: 2133:SCITRI_RS07445
uniprot id: A0A1J0Z2E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

2133:SCITRI RS00540
gene id: 2133:SCITRI_RS00540
uniprot id: Q14Q96
names: Similarity
messages: Belongs to the IMPACT family.

2133:SCITRI RS08310
gene id: 2133:SCITRI_RS08310
uniprot id: Q14L95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.

2133:SCITRI RS03755
gene id: 2133:SCITRI_RS03755
uniprot id: Q14MG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

2133:SCITRI RS04815
gene id: 2133:SCITRI_RS04815
uniprot id: Q14N88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

2133:SCITRI RS00015
gene id: 2133:SCITRI_RS00015
uniprot id: A0A1J0YYF1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

2133:SCITRI RS06370
gene id: 2133:SCITRI_RS06370
uniprot id: Q14NW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane

2133:SCITRI RS09305
gene id: 2133:SCITRI_RS09305
uniprot id: Q14QI3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

2133:SCITRI RS07365
gene id: 2133:SCITRI_RS07365
uniprot id: A0A1J0Z372
names: Similarity
messages: Belongs to the UPF0236 family.

2133:SCITRI RS05455
gene id: 2133:SCITRI_RS05455
uniprot id: A0A1J0Z176
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

2133:SCITRI RS09205
gene id: 2133:SCITRI_RS09205
uniprot id: A0A1J0Z3E4
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.

2133:SCITRI RS01265
gene id: 2133:SCITRI_RS01265
uniprot id: A0A1J0YYW4
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS00430
gene id: 2133:SCITRI_RS00430
uniprot id: Q14QA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

2133:SCITRI RS05240
gene id: 2133:SCITRI_RS05240
uniprot id: A0A1J0Z260
names: Similarity
messages: Belongs to the UPF0236 family.

2133:SCITRI RS02835
gene id: 2133:SCITRI_RS02835
uniprot id: A0A1J0YZR4
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

2133:SCITRI RS06205
gene id: 2133:SCITRI_RS06205
uniprot id: Q14NT1
names: Similarity
messages: Belongs to the DEAD box helicase family.

2133:SCITRI RS05410
gene id: 2133:SCITRI_RS05410
uniprot id: A0A1J0Z292
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

2133:SCITRI RS05450
gene id: 2133:SCITRI_RS05450
uniprot id: Q14NK8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

2133:SCITRI RS04575
gene id: 2133:SCITRI_RS04575
uniprot id: Q14MV1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

2133:SCITRI RS09195
gene id: 2133:SCITRI_RS09195
uniprot id: Q14QK8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

2133:SCITRI RS02260
gene id: 2133:SCITRI_RS02260
uniprot id: Q14P69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

2133:SCITRI RS07450
gene id: 2133:SCITRI_RS07450
uniprot id: A0A1J0Z2H4
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS00115
gene id: 2133:SCITRI_RS00115
uniprot id: Q14QF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

2133:SCITRI RS00940
gene id: 2133:SCITRI_RS00940
uniprot id: Q14PX8
names: Similarity
messages: Belongs to the LacAB/RpiB family.

2133:SCITRI RS01430
gene id: 2133:SCITRI_RS01430
uniprot id: Q462Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginine deiminase family.
messages: Cytoplasm

2133:SCITRI RS06350
gene id: 2133:SCITRI_RS06350
uniprot id: Q14NW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

2133:SCITRI RS08840
gene id: 2133:SCITRI_RS08840
uniprot id: Q14L08
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

2133:SCITRI RS08480
gene id: 2133:SCITRI_RS08480
uniprot id: A0A1J0Z2Z3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

2133:SCITRI RS02240
gene id: 2133:SCITRI_RS02240
uniprot id: A0A1J0YZG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

2133:SCITRI RS06085
gene id: 2133:SCITRI_RS06085
uniprot id: Q14NQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

2133:SCITRI RS01700
gene id: 2133:SCITRI_RS01700
uniprot id: Q14PI5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

2133:SCITRI RS05445
gene id: 2133:SCITRI_RS05445
uniprot id: Q14NK7
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS00955
gene id: 2133:SCITRI_RS00955
uniprot id: A0A6M5JKV7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

2133:SCITRI RS09295
gene id: 2133:SCITRI_RS09295
uniprot id: A0A6I7GU95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Cell membrane
messages: Membrane

2133:SCITRI RS06175
gene id: 2133:SCITRI_RS06175
uniprot id: Q14NS4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS07585
gene id: 2133:SCITRI_RS07585
uniprot id: Q14LR9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

2133:SCITRI RS09800
gene id: 2133:SCITRI_RS09800
uniprot id: A0A1J0YZ51
names: Similarity
messages: Belongs to the UPF0236 family.

2133:SCITRI RS02470
gene id: 2133:SCITRI_RS02470
uniprot id: Q14P21
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

2133:SCITRI RS02020
gene id: 2133:SCITRI_RS02020
uniprot id: Q14PC3
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

2133:SCITRI RS01070
gene id: 2133:SCITRI_RS01070
uniprot id: A0A1J0YYR9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

2133:SCITRI RS00405
gene id: 2133:SCITRI_RS00405
uniprot id: Q14QB2
names: Similarity
messages: Belongs to the UPF0236 family.

2133:SCITRI RS09145
gene id: 2133:SCITRI_RS09145
uniprot id: A0A1J0Z3D0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

2133:SCITRI RS03735
gene id: 2133:SCITRI_RS03735
uniprot id: Q14MF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

2133:SCITRI RS08890
gene id: 2133:SCITRI_RS08890
uniprot id: A0A1J0Z3A7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

2133:SCITRI RS07385
gene id: 2133:SCITRI_RS07385
uniprot id: A0A1J0Z2P4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

2133:SCITRI RS05525
gene id: 2133:SCITRI_RS05525
uniprot id: A0A1J0Z1L9
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS05825
gene id: 2133:SCITRI_RS05825
uniprot id: A0A1J0Z1Q8
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS07735
gene id: 2133:SCITRI_RS07735
uniprot id: A0A1J0Z2I4
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

2133:SCITRI RS05385
gene id: 2133:SCITRI_RS05385
uniprot id: A0A1J0Z174
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS07105
gene id: 2133:SCITRI_RS07105
uniprot id: A0A1J0Z318
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS02150
gene id: 2133:SCITRI_RS02150
uniprot id: Q14P95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

2133:SCITRI RS09200
gene id: 2133:SCITRI_RS09200
uniprot id: Q14QK7
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

2133:SCITRI RS08300
gene id: 2133:SCITRI_RS08300
uniprot id: A0A1J0Z2X5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

2133:SCITRI RS08820
gene id: 2133:SCITRI_RS08820
uniprot id: A0A1J0Z3D2
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

2133:SCITRI RS01210
gene id: 2133:SCITRI_RS01210
uniprot id: A0A1J0YZW2
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

2133:SCITRI RS01645
gene id: 2133:SCITRI_RS01645
uniprot id: Q14PJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

2133:SCITRI RS09190
gene id: 2133:SCITRI_RS09190
uniprot id: Q14QK9
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

2133:SCITRI RS07605
gene id: 2133:SCITRI_RS07605
uniprot id: Q14LR6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

2133:SCITRI RS01575
gene id: 2133:SCITRI_RS01575
uniprot id: Q14PL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

2133:SCITRI RS02115
gene id: 2133:SCITRI_RS02115
uniprot id: Q14PA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

2133:SCITRI RS02485
gene id: 2133:SCITRI_RS02485
uniprot id: A0A1J0Z0E5
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

2133:SCITRI RS07750
gene id: 2133:SCITRI_RS07750
uniprot id: Q14LL1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

2133:SCITRI RS00400
gene id: 2133:SCITRI_RS00400
uniprot id: Q14QB3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

2133:SCITRI RS03955
gene id: 2133:SCITRI_RS03955
uniprot id: Q14LX6
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

2133:SCITRI RS01725
gene id: 2133:SCITRI_RS01725
uniprot id: A0A1J0YZ28
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

2133:SCITRI RS00720
gene id: 2133:SCITRI_RS00720
uniprot id: Q14Q20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

2133:SCITRI RS01080
gene id: 2133:SCITRI_RS01080
uniprot id: Q14PT8
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

2133:SCITRI RS00010
gene id: 2133:SCITRI_RS00010
uniprot id: A0A1J0YYC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

2133:SCITRI RS01675
gene id: 2133:SCITRI_RS01675
uniprot id: Q14PJ0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

2133:SCITRI RS02415
gene id: 2133:SCITRI_RS02415
uniprot id: Q14P34
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

2133:SCITRI RS08600
gene id: 2133:SCITRI_RS08600
uniprot id: A0A1J0Z385
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS05430
gene id: 2133:SCITRI_RS05430
uniprot id: Q14NK4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. RnhC subfamily.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

2133:SCITRI RS00025
gene id: 2133:SCITRI_RS00025
uniprot id: A0A1J0YY29
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS00425
gene id: 2133:SCITRI_RS00425
uniprot id: Q14QA8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

2133:SCITRI RS00780
gene id: 2133:SCITRI_RS00780
uniprot id: A0A1J0YZL8
uniprot id: Q14Q07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Cell membrane
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

2133:SCITRI RS09310
gene id: 2133:SCITRI_RS09310
uniprot id: Q14QI2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

2133:SCITRI RS07600
gene id: 2133:SCITRI_RS07600
uniprot id: Q14LR7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

2133:SCITRI RS00110
gene id: 2133:SCITRI_RS00110
uniprot id: Q14QG0
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS02830
gene id: 2133:SCITRI_RS02830
uniprot id: A0A1J0Z0K8
names: Similarity
messages: Belongs to the transketolase family.

2133:SCITRI RS02455
gene id: 2133:SCITRI_RS02455
uniprot id: A0A5B8XJ25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

2133:SCITRI RS02025
gene id: 2133:SCITRI_RS02025
uniprot id: A0A5B8XH88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

2133:SCITRI RS01500
gene id: 2133:SCITRI_RS01500
uniprot id: Q14PM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).

2133:SCITRI RS01065
gene id: 2133:SCITRI_RS01065
uniprot id: Q14PU1
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

2133:SCITRI RS06070
gene id: 2133:SCITRI_RS06070
uniprot id: A0A1J0Z1L3
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

2133:SCITRI RS00675
gene id: 2133:SCITRI_RS00675
uniprot id: Q14Q29
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

2133:SCITRI RS01075
gene id: 2133:SCITRI_RS01075
uniprot id: A0A1J0YYS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

2133:SCITRI RS01440
gene id: 2133:SCITRI_RS01440
uniprot id: Q462Q0
names: Subcellular Location Annotation
messages: Membrane

2133:SCITRI RS06105
gene id: 2133:SCITRI_RS06105
uniprot id: Q14NQ7
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2133:SCITRI RS05905
gene id: 2133:SCITRI_RS05905
uniprot id: A0A1J0Z1S3
names: Similarity
messages: Belongs to the UPF0236 family.