2124:EXC60 RS00560
gene id: 2124:EXC60_RS00560
uniprot id: A0A448ZYB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

2124:EXC60 RS05910
gene id: 2124:EXC60_RS05910
uniprot id: A0A448ZXW4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2124:EXC60 RS00200
gene id: 2124:EXC60_RS00200
uniprot id: A0A448ZXV6
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

2124:EXC60 RS01940
gene id: 2124:EXC60_RS01940
uniprot id: A0A448ZYW2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

2124:EXC60 RS00380
gene id: 2124:EXC60_RS00380
uniprot id: A0A448ZXZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

2124:EXC60 RS00510
gene id: 2124:EXC60_RS00510
uniprot id: A0A448ZYD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

2124:EXC60 RS01920
gene id: 2124:EXC60_RS01920
uniprot id: A0A448ZYS9
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2124:EXC60 RS01360
gene id: 2124:EXC60_RS01360
uniprot id: A0A448ZYG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

2124:EXC60 RS06245
gene id: 2124:EXC60_RS06245
uniprot id: A0A448ZYP2
names: Similarity
messages: Belongs to the ATPase gamma chain family.

2124:EXC60 RS02580
gene id: 2124:EXC60_RS02580
uniprot id: A0A448ZZ89
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

2124:EXC60 RS00310
gene id: 2124:EXC60_RS00310
uniprot id: A0A448ZXX2
names: Subcellular Location Annotation
messages: Membrane

2124:EXC60 RS02040
gene id: 2124:EXC60_RS02040
uniprot id: A0A448ZYY6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2124:EXC60 RS01055
gene id: 2124:EXC60_RS01055
uniprot id: A0A448ZYA9
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

2124:EXC60 RS00760
gene id: 2124:EXC60_RS00760
uniprot id: A0A448ZYH7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2124:EXC60 RS06940
gene id: 2124:EXC60_RS06940
uniprot id: A0A448ZZF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

2124:EXC60 RS06030
gene id: 2124:EXC60_RS06030
uniprot id: A0A448ZY48
names: Similarity
messages: Belongs to the CTP synthase family.

2124:EXC60 RS06865
gene id: 2124:EXC60_RS06865
uniprot id: A0A448ZZD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Cell membrane
messages: Membrane

2124:EXC60 RS02025
gene id: 2124:EXC60_RS02025
uniprot id: A0A448ZYT2
names: Similarity
messages: Belongs to the peptidase M13 family.

2124:EXC60 RS06400
gene id: 2124:EXC60_RS06400
uniprot id: A0A448ZYP8
names: Subcellular Location Annotation
messages: Membrane

2124:EXC60 RS02855
gene id: 2124:EXC60_RS02855
uniprot id: A0A448ZZD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

2124:EXC60 RS02180
gene id: 2124:EXC60_RS02180
uniprot id: A0A448ZYW0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

2124:EXC60 RS03155
gene id: 2124:EXC60_RS03155
uniprot id: A0A448ZZI5
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

2124:EXC60 RS00280
gene id: 2124:EXC60_RS00280
uniprot id: A0A448ZXZ2
names: Similarity
messages: Belongs to the DprA/Smf family.

2124:EXC60 RS06510
gene id: 2124:EXC60_RS06510
uniprot id: A0A448ZYW4
names: Subcellular Location Annotation
messages: Membrane

2124:EXC60 RS06055
gene id: 2124:EXC60_RS06055
uniprot id: A0A448ZY87
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

2124:EXC60 RS02045
gene id: 2124:EXC60_RS02045
uniprot id: A0A448ZZ44
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

2124:EXC60 RS02540
gene id: 2124:EXC60_RS02540
uniprot id: A0A448ZZ71
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

2124:EXC60 RS02060
gene id: 2124:EXC60_RS02060
uniprot id: A0A448ZYX5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2124:EXC60 RS00130
gene id: 2124:EXC60_RS00130
uniprot id: A0A448ZXW1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

2124:EXC60 RS02750
gene id: 2124:EXC60_RS02750
uniprot id: A0A448ZZC0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2124:EXC60 RS06040
gene id: 2124:EXC60_RS06040
uniprot id: A0A448ZY80
names: Similarity
messages: Belongs to the peptidase A8 family.

2124:EXC60 RS02680
gene id: 2124:EXC60_RS02680
uniprot id: A0A448ZZA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

2124:EXC60 RS02505
gene id: 2124:EXC60_RS02505
uniprot id: A0A448ZZ66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane

2124:EXC60 RS02765
gene id: 2124:EXC60_RS02765
uniprot id: A0A448ZZB6
names: Similarity
messages: Belongs to the MG185/MG260 family.

2124:EXC60 RS06280
gene id: 2124:EXC60_RS06280
uniprot id: A0A448ZYK0
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

2124:EXC60 RS01355
gene id: 2124:EXC60_RS01355
uniprot id: A0A448ZYE8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

2124:EXC60 RS06490
gene id: 2124:EXC60_RS06490
uniprot id: A0A448ZZ29
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2124:EXC60 RS03075
gene id: 2124:EXC60_RS03075
uniprot id: A0A448ZZH7
names: Subcellular Location Annotation
messages: Membrane

2124:EXC60 RS01010
gene id: 2124:EXC60_RS01010
uniprot id: A0A448ZY83
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

2124:EXC60 RS06420
gene id: 2124:EXC60_RS06420
uniprot id: A0A448ZYQ8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

2124:EXC60 RS06100
gene id: 2124:EXC60_RS06100
uniprot id: A0A448ZYB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

2124:EXC60 RS02510
gene id: 2124:EXC60_RS02510
uniprot id: A0A448ZZ61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

2124:EXC60 RS00080
gene id: 2124:EXC60_RS00080
uniprot id: A0A448ZXU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

2124:EXC60 RS06035
gene id: 2124:EXC60_RS06035
uniprot id: A0A448ZY49
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

2124:EXC60 RS01995
gene id: 2124:EXC60_RS01995
uniprot id: A0A448ZZ39
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2124:EXC60 RS01120
gene id: 2124:EXC60_RS01120
uniprot id: A0A448ZYB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

2124:EXC60 RS01885
gene id: 2124:EXC60_RS01885
uniprot id: A0A448ZYU5
names: Similarity
messages: Belongs to the LacAB/RpiB family.

2124:EXC60 RS06550
gene id: 2124:EXC60_RS06550
uniprot id: A0A448ZYZ3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

2124:EXC60 RS00710
gene id: 2124:EXC60_RS00710
uniprot id: A0A448ZYG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

2124:EXC60 RS01095
gene id: 2124:EXC60_RS01095
uniprot id: A0A448ZYK4
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

2124:EXC60 RS01195
gene id: 2124:EXC60_RS01195
uniprot id: A0A448ZYP0
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

2124:EXC60 RS05905
gene id: 2124:EXC60_RS05905
uniprot id: A0A448ZXY2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

2124:EXC60 RS03185
gene id: 2124:EXC60_RS03185
uniprot id: A0A448ZZJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

2124:EXC60 RS00125
gene id: 2124:EXC60_RS00125
uniprot id: A0A448ZXU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

2124:EXC60 RS02530
gene id: 2124:EXC60_RS02530
uniprot id: A0A448ZZ79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

2124:EXC60 RS00115
gene id: 2124:EXC60_RS00115
uniprot id: A0A448ZXT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

2124:EXC60 RS00430
gene id: 2124:EXC60_RS00430
uniprot id: A0A448ZXZ9
names: Similarity
messages: Belongs to the transketolase family.

2124:EXC60 RS02525
gene id: 2124:EXC60_RS02525
uniprot id: A0A448ZZ75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

2124:EXC60 RS06795
gene id: 2124:EXC60_RS06795
uniprot id: A0A448ZZ95
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

2124:EXC60 RS00175
gene id: 2124:EXC60_RS00175
uniprot id: A0A448ZXV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

2124:EXC60 RS02910
gene id: 2124:EXC60_RS02910
uniprot id: A0A448ZZF1
names: Similarity
messages: Belongs to the RecO family.

2124:EXC60 RS00045
gene id: 2124:EXC60_RS00045
uniprot id: A0A448ZY11
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

2124:EXC60 RS00225
gene id: 2124:EXC60_RS00225
uniprot id: A0A448ZXW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

2124:EXC60 RS00135
gene id: 2124:EXC60_RS00135
uniprot id: A0A448ZXV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

2124:EXC60 RS00995
gene id: 2124:EXC60_RS00995
uniprot id: A0A448ZYA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

2124:EXC60 RS02875
gene id: 2124:EXC60_RS02875
uniprot id: A0A448ZZD9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

2124:EXC60 RS01960
gene id: 2124:EXC60_RS01960
uniprot id: A0A448ZYV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

2124:EXC60 RS02740
gene id: 2124:EXC60_RS02740
uniprot id: A0A448ZZB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

2124:EXC60 RS05915
gene id: 2124:EXC60_RS05915
uniprot id: A0A448ZYB2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

2124:EXC60 RS01080
gene id: 2124:EXC60_RS01080
uniprot id: A0A448ZYE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

2124:EXC60 RS00350
gene id: 2124:EXC60_RS00350
uniprot id: A0A448ZY74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

2124:EXC60 RS00715
gene id: 2124:EXC60_RS00715
uniprot id: A0A448ZYE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

2124:EXC60 RS00515
gene id: 2124:EXC60_RS00515
uniprot id: A0A448ZYA5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

2124:EXC60 RS02245
gene id: 2124:EXC60_RS02245
uniprot id: A0A448ZZ52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2124:EXC60 RS05895
gene id: 2124:EXC60_RS05895
uniprot id: A0A448ZYA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

2124:EXC60 RS02285
gene id: 2124:EXC60_RS02285
uniprot id: A0A448ZZ21
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

2124:EXC60 RS01175
gene id: 2124:EXC60_RS01175
uniprot id: A0A448ZYC6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

2124:EXC60 RS03175
gene id: 2124:EXC60_RS03175
uniprot id: A0A448ZZJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2124:EXC60 RS06320
gene id: 2124:EXC60_RS06320
uniprot id: A0A448ZYU6
names: Subcellular Location Annotation
messages: Membrane

2124:EXC60 RS01875
gene id: 2124:EXC60_RS01875
uniprot id: A0A448ZYQ6
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

2124:EXC60 RS02360
gene id: 2124:EXC60_RS02360
uniprot id: A0A448ZZ25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

2124:EXC60 RS01900
gene id: 2124:EXC60_RS01900
uniprot id: A0A448ZZ13
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

2124:EXC60 RS00750
gene id: 2124:EXC60_RS00750
uniprot id: A0A448ZY93
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

2124:EXC60 RS00320
gene id: 2124:EXC60_RS00320
uniprot id: A0A448ZXX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

2124:EXC60 RS00375
gene id: 2124:EXC60_RS00375
uniprot id: A0A448ZXY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

2124:EXC60 RS02850
gene id: 2124:EXC60_RS02850
uniprot id: A0A448ZZD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta sliding clamp family.
messages: Cytoplasm

2124:EXC60 RS02100
gene id: 2124:EXC60_RS02100
uniprot id: A0A448ZZ42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

2124:EXC60 RS03265
gene id: 2124:EXC60_RS03265
uniprot id: A0A448ZZK6
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2124:EXC60 RS02055
gene id: 2124:EXC60_RS02055
uniprot id: A0A448ZYW8
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

2124:EXC60 RS01935
gene id: 2124:EXC60_RS01935
uniprot id: A0A448ZYV5
names: Subcellular Location Annotation
messages: Membrane

2124:EXC60 RS00300
gene id: 2124:EXC60_RS00300
uniprot id: A0A448ZY63
names: Subcellular Location Annotation
messages: Membrane

2124:EXC60 RS01965
gene id: 2124:EXC60_RS01965
uniprot id: A0A448ZYR6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2124:EXC60 RS01170
gene id: 2124:EXC60_RS01170
uniprot id: A0A448ZYC4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2124:EXC60 RS00165
gene id: 2124:EXC60_RS00165
uniprot id: A0A448ZXU0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

2124:EXC60 RS01030
gene id: 2124:EXC60_RS01030
uniprot id: A0A448ZYC7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

2124:EXC60 RS02980
gene id: 2124:EXC60_RS02980
uniprot id: A0A448ZZG1
names: Similarity
messages: Belongs to the ClpA/ClpB family.

2124:EXC60 RS06845
gene id: 2124:EXC60_RS06845
uniprot id: A0A448ZZC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2124:EXC60 RS00370
gene id: 2124:EXC60_RS00370
uniprot id: A0A448ZXY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

2124:EXC60 RS02515
gene id: 2124:EXC60_RS02515
uniprot id: A0A448ZZ74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

2124:EXC60 RS02065
gene id: 2124:EXC60_RS02065
uniprot id: A0A448ZYT3
names: Similarity
messages: Belongs to the RRF family.

2124:EXC60 RS01165
gene id: 2124:EXC60_RS01165
uniprot id: A0A448ZYB1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

2124:EXC60 RS06485
gene id: 2124:EXC60_RS06485
uniprot id: A0A448ZYV3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2124:EXC60 RS00575
gene id: 2124:EXC60_RS00575
uniprot id: A0A448ZY07
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

2124:EXC60 RS01510
gene id: 2124:EXC60_RS01510
uniprot id: A0A448ZYI5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

2124:EXC60 RS01015
gene id: 2124:EXC60_RS01015
uniprot id: A0A448ZY97
names: Similarity
messages: Belongs to the IMPACT family.

2124:EXC60 RS00415
gene id: 2124:EXC60_RS00415
uniprot id: A0A448ZXZ1
names: Similarity
messages: Belongs to the NAD synthetase family.

2124:EXC60 RS00155
gene id: 2124:EXC60_RS00155
uniprot id: A0A448ZXU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

2124:EXC60 RS02105
gene id: 2124:EXC60_RS02105
uniprot id: A0A448ZYX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

2124:EXC60 RS06785
gene id: 2124:EXC60_RS06785
uniprot id: A0A448ZZ96
names: Similarity
messages: Belongs to the ABC transporter superfamily.

2124:EXC60 RS05865
gene id: 2124:EXC60_RS05865
uniprot id: A0A448ZXS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

2124:EXC60 RS06760
gene id: 2124:EXC60_RS06760
uniprot id: A0A448ZZ82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Cytoplasm

2124:EXC60 RS03150
gene id: 2124:EXC60_RS03150
uniprot id: A0A448ZZI1
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

2124:EXC60 RS02390
gene id: 2124:EXC60_RS02390
uniprot id: A0A448ZZ40
names: Similarity
messages: Belongs to the Fmt family.

2124:EXC60 RS00870
gene id: 2124:EXC60_RS00870
uniprot id: A0A448ZY79
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

2124:EXC60 RS06675
gene id: 2124:EXC60_RS06675
uniprot id: A0A448ZZ57
names: Similarity
messages: Belongs to the UPF0236 family.

2124:EXC60 RS01560
gene id: 2124:EXC60_RS01560
uniprot id: A0A448ZYN7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

2124:EXC60 RS06965
gene id: 2124:EXC60_RS06965
uniprot id: A0A448ZZH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

2124:EXC60 RS06130
gene id: 2124:EXC60_RS06130
uniprot id: A0A448ZY96
names: Subcellular Location Annotation
messages: Membrane

2124:EXC60 RS01720
gene id: 2124:EXC60_RS01720
uniprot id: A0A448ZYR3
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

2124:EXC60 RS00745
gene id: 2124:EXC60_RS00745
uniprot id: A0A448ZY58
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

2124:EXC60 RS06110
gene id: 2124:EXC60_RS06110
uniprot id: A0A448ZYJ6
names: Similarity
messages: Belongs to the RibF family.

2124:EXC60 RS06525
gene id: 2124:EXC60_RS06525
uniprot id: A0A448ZYW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

2124:EXC60 RS01840
gene id: 2124:EXC60_RS01840
uniprot id: A0A448ZYU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

2124:EXC60 RS06190
gene id: 2124:EXC60_RS06190
uniprot id: A0A448ZYE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

2124:EXC60 RS01975
gene id: 2124:EXC60_RS01975
uniprot id: A0A448ZYS3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

2124:EXC60 RS00065
gene id: 2124:EXC60_RS00065
uniprot id: A0A448ZXS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

2124:EXC60 RS00190
gene id: 2124:EXC60_RS00190
uniprot id: A0A448ZY72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

2124:EXC60 RS06905
gene id: 2124:EXC60_RS06905
uniprot id: A0A448ZZF8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

2124:EXC60 RS02825
gene id: 2124:EXC60_RS02825
uniprot id: A0A448ZZC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

2124:EXC60 RS00170
gene id: 2124:EXC60_RS00170
uniprot id: A0A448ZXU7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

2124:EXC60 RS03250
gene id: 2124:EXC60_RS03250
uniprot id: A0A448ZZK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

2124:EXC60 RS00975
gene id: 2124:EXC60_RS00975
uniprot id: A0A448ZYC3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

2124:EXC60 RS01555
gene id: 2124:EXC60_RS01555
uniprot id: A0A448ZYN6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

2124:EXC60 RS01320
gene id: 2124:EXC60_RS01320
uniprot id: A0A448ZYF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

2124:EXC60 RS01620
gene id: 2124:EXC60_RS01620
uniprot id: A0A448ZYY5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

2124:EXC60 RS06515
gene id: 2124:EXC60_RS06515
uniprot id: A0A448ZYS2
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

2124:EXC60 RS01690
gene id: 2124:EXC60_RS01690
uniprot id: A0A448ZYL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.

2124:EXC60 RS01665
gene id: 2124:EXC60_RS01665
uniprot id: A0A448ZYQ9
names: Similarity
messages: Belongs to the peptidase C1 family.

2124:EXC60 RS02735
gene id: 2124:EXC60_RS02735
uniprot id: A0A448ZZB8
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

2124:EXC60 RS00245
gene id: 2124:EXC60_RS00245
uniprot id: A0A448ZY53
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.

2124:EXC60 RS01600
gene id: 2124:EXC60_RS01600
uniprot id: A0A448ZYK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

2124:EXC60 RS01905
gene id: 2124:EXC60_RS01905
uniprot id: A0A448ZYT8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

2124:EXC60 RS01025
gene id: 2124:EXC60_RS01025
uniprot id: A0A448ZYD3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

2124:EXC60 RS00410
gene id: 2124:EXC60_RS00410
uniprot id: A0A448ZXZ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

2124:EXC60 RS00195
gene id: 2124:EXC60_RS00195
uniprot id: A0A448ZY44
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

2124:EXC60 RS02745
gene id: 2124:EXC60_RS02745
uniprot id: A0A448ZZB7
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

2124:EXC60 RS03135
gene id: 2124:EXC60_RS03135
uniprot id: A0A448ZZH9
names: Similarity
messages: Belongs to the TlyA family.

2124:EXC60 RS06085
gene id: 2124:EXC60_RS06085
uniprot id: A0A448ZY56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

2124:EXC60 RS00435
gene id: 2124:EXC60_RS00435
uniprot id: A0A448ZY05
names: Similarity
messages: Belongs to the peptidase S66 family.

2124:EXC60 RS03200
gene id: 2124:EXC60_RS03200
uniprot id: A0A448ZZI9
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

2124:EXC60 RS01090
gene id: 2124:EXC60_RS01090
uniprot id: A0A448ZYM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

2124:EXC60 RS01345
gene id: 2124:EXC60_RS01345
uniprot id: A0A448ZYH3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

2124:EXC60 RS00635
gene id: 2124:EXC60_RS00635
uniprot id: A0A448ZY28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

2124:EXC60 RS00915
gene id: 2124:EXC60_RS00915
uniprot id: A0A448ZY91
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.

2124:EXC60 RS01135
gene id: 2124:EXC60_RS01135
uniprot id: A0A448ZYF0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

2124:EXC60 RS06565
gene id: 2124:EXC60_RS06565
uniprot id: A0A448ZYZ4
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

2124:EXC60 RS06465
gene id: 2124:EXC60_RS06465
uniprot id: A0A448ZYP5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

2124:EXC60 RS03100
gene id: 2124:EXC60_RS03100
uniprot id: A0A448ZZH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

2124:EXC60 RS00145
gene id: 2124:EXC60_RS00145
uniprot id: A0A448ZY33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

2124:EXC60 RS06610
gene id: 2124:EXC60_RS06610
uniprot id: A0A448ZZ20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

2124:EXC60 RS00545
gene id: 2124:EXC60_RS00545
uniprot id: A0A448ZY45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

2124:EXC60 RS00340
gene id: 2124:EXC60_RS00340
uniprot id: A0A448ZXZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

2124:EXC60 RS00970
gene id: 2124:EXC60_RS00970
uniprot id: A0A448ZY86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

2124:EXC60 RS01185
gene id: 2124:EXC60_RS01185
uniprot id: A0A448ZYG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

2124:EXC60 RS00405
gene id: 2124:EXC60_RS00405
uniprot id: A0A448ZY85
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

2124:EXC60 RS00565
gene id: 2124:EXC60_RS00565
uniprot id: A0A448ZY27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

2124:EXC60 RS02295
gene id: 2124:EXC60_RS02295
uniprot id: A0A448ZZ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

2124:EXC60 RS01110
gene id: 2124:EXC60_RS01110
uniprot id: A0A448ZY94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

2124:EXC60 RS01820
gene id: 2124:EXC60_RS01820
uniprot id: A0A448ZYR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

2124:EXC60 RS06375
gene id: 2124:EXC60_RS06375
uniprot id: A0A448ZYN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2124:EXC60 RS03105
gene id: 2124:EXC60_RS03105
uniprot id: A0A448ZZH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

2124:EXC60 RS01230
gene id: 2124:EXC60_RS01230
uniprot id: A0A448ZYD6
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

2124:EXC60 RS00140
gene id: 2124:EXC60_RS00140
uniprot id: A0A448ZY62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

2124:EXC60 RS00100
gene id: 2124:EXC60_RS00100
uniprot id: A0A448ZXT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

2124:EXC60 RS01115
gene id: 2124:EXC60_RS01115
uniprot id: A0A448ZYA2
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

2124:EXC60 RS00260
gene id: 2124:EXC60_RS00260
uniprot id: A0A448ZXU4
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

2124:EXC60 RS00185
gene id: 2124:EXC60_RS00185
uniprot id: A0A448ZXW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

2124:EXC60 RS01730
gene id: 2124:EXC60_RS01730
uniprot id: A0A448ZZ05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginine deiminase family.
messages: Cytoplasm

2124:EXC60 RS03170
gene id: 2124:EXC60_RS03170
uniprot id: A0A448ZZJ3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

2124:EXC60 RS00860
gene id: 2124:EXC60_RS00860
uniprot id: A0A448ZYG0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

2124:EXC60 RS02535
gene id: 2124:EXC60_RS02535
uniprot id: A0A448ZZ76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

2124:EXC60 RS00570
gene id: 2124:EXC60_RS00570
uniprot id: A0A448ZY29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

2124:EXC60 RS00075
gene id: 2124:EXC60_RS00075
uniprot id: A0A448ZXT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

2124:EXC60 RS06080
gene id: 2124:EXC60_RS06080
uniprot id: A0A448ZYA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm

2124:EXC60 RS02075
gene id: 2124:EXC60_RS02075
uniprot id: A0A448ZYU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

2124:EXC60 RS02140
gene id: 2124:EXC60_RS02140
uniprot id: A0A448ZZ04
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

2124:EXC60 RS02350
gene id: 2124:EXC60_RS02350
uniprot id: A0A448ZZ55
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

2124:EXC60 RS02520
gene id: 2124:EXC60_RS02520
uniprot id: A0A448ZZ80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

2124:EXC60 RS02555
gene id: 2124:EXC60_RS02555
uniprot id: A0A448ZZ72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

2124:EXC60 RS05860
gene id: 2124:EXC60_RS05860
uniprot id: A0A448ZXR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

2124:EXC60 RS01835
gene id: 2124:EXC60_RS01835
uniprot id: A0A448ZYT1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

2124:EXC60 RS00205
gene id: 2124:EXC60_RS00205
uniprot id: A0A448ZXV3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

2124:EXC60 RS01315
gene id: 2124:EXC60_RS01315
uniprot id: A0A448ZYF1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

2124:EXC60 RS00180
gene id: 2124:EXC60_RS00180
uniprot id: A0A448ZXX0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

2124:EXC60 RS01085
gene id: 2124:EXC60_RS01085
uniprot id: A0A448ZYE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

2124:EXC60 RS03060
gene id: 2124:EXC60_RS03060
uniprot id: A0A448ZZG3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2124:EXC60 RS00120
gene id: 2124:EXC60_RS00120
uniprot id: A0A448ZXT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

2124:EXC60 RS00490
gene id: 2124:EXC60_RS00490
uniprot id: A0A448ZY10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

2124:EXC60 RS06295
gene id: 2124:EXC60_RS06295
uniprot id: A0A448ZYI9
names: Subcellular Location Annotation
messages: Membrane

2124:EXC60 RS02370
gene id: 2124:EXC60_RS02370
uniprot id: A0A448ZZ18
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

2124:EXC60 RS00095
gene id: 2124:EXC60_RS00095
uniprot id: A0A448ZY22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

2124:EXC60 RS02375
gene id: 2124:EXC60_RS02375
uniprot id: A0A448ZZ07
names: Similarity
messages: Belongs to the peptidase M17 family.

2124:EXC60 RS01400
gene id: 2124:EXC60_RS01400
uniprot id: A0A448ZYF8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2124:EXC60 RS02270
gene id: 2124:EXC60_RS02270
uniprot id: A0A448ZYZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

2124:EXC60 RS02085
gene id: 2124:EXC60_RS02085
uniprot id: A0A448ZYY4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2124:EXC60 RS00050
gene id: 2124:EXC60_RS00050
uniprot id: A0A448ZXS4
names: Similarity
messages: Belongs to the XFP family.

2124:EXC60 RS01450
gene id: 2124:EXC60_RS01450
uniprot id: A0A448ZYG8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

2124:EXC60 RS00305
gene id: 2124:EXC60_RS00305
uniprot id: A0A448ZXX8
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

2124:EXC60 RS00420
gene id: 2124:EXC60_RS00420
uniprot id: A0A448ZXX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

2124:EXC60 RS06225
gene id: 2124:EXC60_RS06225
uniprot id: A0A448ZYF5
names: Similarity
messages: Belongs to the ATPase gamma chain family.

2124:EXC60 RS02880
gene id: 2124:EXC60_RS02880
uniprot id: A0A448ZZD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

2124:EXC60 RS00030
gene id: 2124:EXC60_RS00030
uniprot id: A0A448ZXT8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2124:EXC60 RS06340
gene id: 2124:EXC60_RS06340
uniprot id: A0A448ZYH9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

2124:EXC60 RS03110
gene id: 2124:EXC60_RS03110
uniprot id: A0A448ZZH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

2124:EXC60 RS06475
gene id: 2124:EXC60_RS06475
uniprot id: A0A448ZYT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2124:EXC60 RS02840
gene id: 2124:EXC60_RS02840
uniprot id: A0A448ZZD5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

2124:EXC60 RS00085
gene id: 2124:EXC60_RS00085
uniprot id: A0A448ZXU1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

2124:EXC60 RS03240
gene id: 2124:EXC60_RS03240
uniprot id: A0A448ZZK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0154 family.
messages: Membrane

2124:EXC60 RS03165
gene id: 2124:EXC60_RS03165
uniprot id: A0A448ZZJ9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

2124:EXC60 RS01985
gene id: 2124:EXC60_RS01985
uniprot id: A0A448ZYW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

2124:EXC60 RS00390
gene id: 2124:EXC60_RS00390
uniprot id: A0A448ZY12
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2124:EXC60 RS00270
gene id: 2124:EXC60_RS00270
uniprot id: A0A448ZXW9
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

2124:EXC60 RS00965
gene id: 2124:EXC60_RS00965
uniprot id: A0A448ZY88
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

2124:EXC60 RS00820
gene id: 2124:EXC60_RS00820
uniprot id: A0A448ZY47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

2124:EXC60 RS01925
gene id: 2124:EXC60_RS01925
uniprot id: A0A448ZYR7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

2124:EXC60 RS02050
gene id: 2124:EXC60_RS02050
uniprot id: A0A448ZZ36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

2124:EXC60 RS02305
gene id: 2124:EXC60_RS02305
uniprot id: A0A448ZZ23
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

2124:EXC60 RS01595
gene id: 2124:EXC60_RS01595
uniprot id: A0A448ZYM5
names: Similarity
messages: Belongs to the carbamate kinase family.

2124:EXC60 RS00990
gene id: 2124:EXC60_RS00990
uniprot id: A0A448ZYI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

2124:EXC60 RS02000
gene id: 2124:EXC60_RS02000
uniprot id: A0A448ZZ31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.