195522:BD01 RS04460
gene id: 195522:BD01_RS04460
uniprot id: W8P1B3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

195522:BD01 RS00125
gene id: 195522:BD01_RS00125
uniprot id: W8P2L7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS10605
gene id: 195522:BD01_RS10605
uniprot id: W8NWW8
names: Similarity
messages: Belongs to the enolase family.

195522:BD01 RS02935
gene id: 195522:BD01_RS02935
uniprot id: W8NSN9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

195522:BD01 RS05500
gene id: 195522:BD01_RS05500
uniprot id: W8P1Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

195522:BD01 RS03610
gene id: 195522:BD01_RS03610
uniprot id: W8P0X5
names: Similarity
messages: Belongs to the HepT RNase toxin family.

195522:BD01 RS00930
gene id: 195522:BD01_RS00930
uniprot id: W8NRV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

195522:BD01 RS06310
gene id: 195522:BD01_RS06310
uniprot id: W8NUT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

195522:BD01 RS04885
gene id: 195522:BD01_RS04885
uniprot id: W8PKM0
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS03055
gene id: 195522:BD01_RS03055
uniprot id: W8NSR0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

195522:BD01 RS08075
gene id: 195522:BD01_RS08075
uniprot id: W8P3E0
names: Subcellular Location Annotation
messages: Cytoplasm

195522:BD01 RS02230
gene id: 195522:BD01_RS02230
uniprot id: W8NSI9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

195522:BD01 RS04800
gene id: 195522:BD01_RS04800
uniprot id: W8NTZ2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

195522:BD01 RS09070
gene id: 195522:BD01_RS09070
uniprot id: W8PN67
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS10345
gene id: 195522:BD01_RS10345
uniprot id: W8PNZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

195522:BD01 RS04700
gene id: 195522:BD01_RS04700
uniprot id: W8NTL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.
messages: Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
messages: Cytoplasm

195522:BD01 RS07815
gene id: 195522:BD01_RS07815
uniprot id: W8P394
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

195522:BD01 RS10175
gene id: 195522:BD01_RS10175
uniprot id: W8P4J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

195522:BD01 RS10630
gene id: 195522:BD01_RS10630
uniprot id: W8NX79
names: Similarity
messages: Belongs to the FUN14 family.

195522:BD01 RS04200
gene id: 195522:BD01_RS04200
uniprot id: W8P4W3
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

195522:BD01 RS10765
gene id: 195522:BD01_RS10765
uniprot id: W8PP72
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

195522:BD01 RS09115
gene id: 195522:BD01_RS09115
uniprot id: W8NW30
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS04640
gene id: 195522:BD01_RS04640
uniprot id: W8PKH5
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

195522:BD01 RS05020
gene id: 195522:BD01_RS05020
uniprot id: W8P1M5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS00560
gene id: 195522:BD01_RS00560
uniprot id: W8NRN5
names: Similarity
messages: Belongs to the HupF/HypC family.

195522:BD01 RS05730
gene id: 195522:BD01_RS05730
uniprot id: W8NU80
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

195522:BD01 RS01520
gene id: 195522:BD01_RS01520
uniprot id: W8P3E1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

195522:BD01 RS01590
gene id: 195522:BD01_RS01590
uniprot id: W8P3F8
names: Similarity
messages: Belongs to the peptidase S49 family.

195522:BD01 RS04105
gene id: 195522:BD01_RS04105
uniprot id: W8P4U1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

195522:BD01 RS06275
gene id: 195522:BD01_RS06275
uniprot id: W8P5X7
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS09155
gene id: 195522:BD01_RS09155
uniprot id: W8P3X8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

195522:BD01 RS01980
gene id: 195522:BD01_RS01980
uniprot id: W8NSF0
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

195522:BD01 RS10085
gene id: 195522:BD01_RS10085
uniprot id: W8NWV0
names: Similarity
messages: Belongs to the ZPR1 family.

195522:BD01 RS08410
gene id: 195522:BD01_RS08410
uniprot id: W8P3J9
names: Similarity
messages: Belongs to the GARS family.

195522:BD01 RS03080
gene id: 195522:BD01_RS03080
uniprot id: W8PJK9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

195522:BD01 RS07470
gene id: 195522:BD01_RS07470
uniprot id: W8P6K8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS09180
gene id: 195522:BD01_RS09180
uniprot id: W8P3Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

195522:BD01 RS08985
gene id: 195522:BD01_RS08985
uniprot id: W8P3V1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

195522:BD01 RS06765
gene id: 195522:BD01_RS06765
uniprot id: W8P667
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

195522:BD01 RS06685
gene id: 195522:BD01_RS06685
uniprot id: W8PLS0
names: Function
messages: Part of a potassium transport system.

195522:BD01 RS03035
gene id: 195522:BD01_RS03035
uniprot id: W8PJJ9
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

195522:BD01 RS09830
gene id: 195522:BD01_RS09830
uniprot id: W8NWG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

195522:BD01 RS06930
gene id: 195522:BD01_RS06930
uniprot id: W8NUT6
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

195522:BD01 RS00840
gene id: 195522:BD01_RS00840
uniprot id: W8PI72
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

195522:BD01 RS08480
gene id: 195522:BD01_RS08480
uniprot id: W8P3L2
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

195522:BD01 RS01910
gene id: 195522:BD01_RS01910
uniprot id: W8NS01
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS10550
gene id: 195522:BD01_RS10550
uniprot id: W8PP35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

195522:BD01 RS00940
gene id: 195522:BD01_RS00940
uniprot id: W8PI85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

195522:BD01 RS01455
gene id: 195522:BD01_RS01455
uniprot id: W8NS47
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

195522:BD01 RS05080
gene id: 195522:BD01_RS05080
uniprot id: W8PKR9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

195522:BD01 RS09455
gene id: 195522:BD01_RS09455
uniprot id: W8P7L5
names: Similarity
messages: Belongs to the AOR/FOR family.

195522:BD01 RS06160
gene id: 195522:BD01_RS06160
uniprot id: W8P298
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

195522:BD01 RS06985
gene id: 195522:BD01_RS06985
uniprot id: W8PLX2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

195522:BD01 RS04925
gene id: 195522:BD01_RS04925
uniprot id: W8NU21
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

195522:BD01 RS07835
gene id: 195522:BD01_RS07835
uniprot id: W8P6V3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

195522:BD01 RS10445
gene id: 195522:BD01_RS10445
uniprot id: W8NWU5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

195522:BD01 RS06260
gene id: 195522:BD01_RS06260
uniprot id: W8P2B4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

195522:BD01 RS03100
gene id: 195522:BD01_RS03100
uniprot id: W8NSS0
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

195522:BD01 RS06980
gene id: 195522:BD01_RS06980
uniprot id: W8NUU4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

195522:BD01 RS03595
gene id: 195522:BD01_RS03595
uniprot id: W8NSZ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

195522:BD01 RS02600
gene id: 195522:BD01_RS02600
uniprot id: W8NSR9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

195522:BD01 RS04790
gene id: 195522:BD01_RS04790
uniprot id: W8P582
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

195522:BD01 RS08780
gene id: 195522:BD01_RS08780
uniprot id: W8NVW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

195522:BD01 RS10825
gene id: 195522:BD01_RS10825
uniprot id: W8P4T9
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS09550
gene id: 195522:BD01_RS09550
uniprot id: W8NWA3
names: Similarity
messages: Belongs to the UPF0282 family.

195522:BD01 RS08145
gene id: 195522:BD01_RS08145
uniprot id: W8P6Z5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

195522:BD01 RS00115
gene id: 195522:BD01_RS00115
uniprot id: W8NR98
names: Similarity
messages: Belongs to the phosphohexose mutase family.

195522:BD01 RS07340
gene id: 195522:BD01_RS07340
uniprot id: W8NV22
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

195522:BD01 RS05805
gene id: 195522:BD01_RS05805
uniprot id: W8NUK9
names: Similarity
messages: Belongs to the BtpA family.

195522:BD01 RS09895
gene id: 195522:BD01_RS09895
uniprot id: W8PNL2
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

195522:BD01 RS00020
gene id: 195522:BD01_RS00020
uniprot id: U3RHL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

195522:BD01 RS04670
gene id: 195522:BD01_RS04670
uniprot id: W8P1F1
names: Similarity
messages: Belongs to the AOR/FOR family.

195522:BD01 RS08475
gene id: 195522:BD01_RS08475
uniprot id: W8P742
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

195522:BD01 RS03730
gene id: 195522:BD01_RS03730
uniprot id: W8PJX7
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS08390
gene id: 195522:BD01_RS08390
uniprot id: W8NW00
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

195522:BD01 RS06125
gene id: 195522:BD01_RS06125
uniprot id: W8PLG2
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

195522:BD01 RS10385
gene id: 195522:BD01_RS10385
uniprot id: W8P4M0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

195522:BD01 RS00695
gene id: 195522:BD01_RS00695
uniprot id: W8P305
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

195522:BD01 RS06870
gene id: 195522:BD01_RS06870
uniprot id: W8P2L6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

195522:BD01 RS09390
gene id: 195522:BD01_RS09390
uniprot id: W8NW80
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

195522:BD01 RS08910
gene id: 195522:BD01_RS08910
uniprot id: W8P7B1
names: Similarity
messages: Belongs to the MoaD family.

195522:BD01 RS06135
gene id: 195522:BD01_RS06135
uniprot id: W8P294
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

195522:BD01 RS09375
gene id: 195522:BD01_RS09375
uniprot id: W8P7J9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

195522:BD01 RS10245
gene id: 195522:BD01_RS10245
uniprot id: W8P864
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

195522:BD01 RS00110
gene id: 195522:BD01_RS00110
uniprot id: W8NYY4
names: Similarity
messages: Belongs to the thymidylate kinase family.

195522:BD01 RS03555
gene id: 195522:BD01_RS03555
uniprot id: W8P4I2
names: Similarity
messages: Belongs to the peptidase M24B family.

195522:BD01 RS00825
gene id: 195522:BD01_RS00825
uniprot id: W8NZD6
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

195522:BD01 RS04330
gene id: 195522:BD01_RS04330
uniprot id: W8NTD5
names: Similarity
messages: Belongs to the UPF0248 family.

195522:BD01 RS05785
gene id: 195522:BD01_RS05785
uniprot id: W8NU86
names: Similarity
messages: Belongs to the peptidase U62 family.

195522:BD01 RS08385
gene id: 195522:BD01_RS08385
uniprot id: W8P3J5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

195522:BD01 RS08870
gene id: 195522:BD01_RS08870
uniprot id: W8P3S9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

195522:BD01 RS08450
gene id: 195522:BD01_RS08450
uniprot id: W8P740
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

195522:BD01 RS10600
gene id: 195522:BD01_RS10600
uniprot id: W8NX75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

195522:BD01 RS08170
gene id: 195522:BD01_RS08170
uniprot id: W8P3F5
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

195522:BD01 RS04830
gene id: 195522:BD01_RS04830
uniprot id: W8NTN3
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

195522:BD01 RS01340
gene id: 195522:BD01_RS01340
uniprot id: W8PIF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

195522:BD01 RS05330
gene id: 195522:BD01_RS05330
uniprot id: W8P5J2
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

195522:BD01 RS09825
gene id: 195522:BD01_RS09825
uniprot id: W8NWP5
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

195522:BD01 RS09755
gene id: 195522:BD01_RS09755
uniprot id: W8NWE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

195522:BD01 RS03890
gene id: 195522:BD01_RS03890
uniprot id: W8P123
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

195522:BD01 RS10105
gene id: 195522:BD01_RS10105
uniprot id: W8P4F8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

195522:BD01 RS07290
gene id: 195522:BD01_RS07290
uniprot id: W8NV09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

195522:BD01 RS03115
gene id: 195522:BD01_RS03115
uniprot id: W8P0P2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

195522:BD01 RS02050
gene id: 195522:BD01_RS02050
uniprot id: W8NZZ2
names: Similarity
messages: Belongs to the UPF0107 family.

195522:BD01 RS01465
gene id: 195522:BD01_RS01465
uniprot id: W8PIH8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

195522:BD01 RS10925
gene id: 195522:BD01_RS10925
uniprot id: W8NX15
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

195522:BD01 RS04025
gene id: 195522:BD01_RS04025
uniprot id: W8PK47
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

195522:BD01 RS07935
gene id: 195522:BD01_RS07935
uniprot id: W8P6W7
names: Similarity
messages: Belongs to the UPF0128 family.

195522:BD01 RS05770
gene id: 195522:BD01_RS05770
uniprot id: W8P5Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

195522:BD01 RS00210
gene id: 195522:BD01_RS00210
uniprot id: W8NRC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

195522:BD01 RS01795
gene id: 195522:BD01_RS01795
uniprot id: W8P3J8
names: Similarity
messages: Belongs to the RuvB family.

195522:BD01 RS07770
gene id: 195522:BD01_RS07770
uniprot id: W8NVN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

195522:BD01 RS06165
gene id: 195522:BD01_RS06165
uniprot id: W8NUQ7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

195522:BD01 RS05420
gene id: 195522:BD01_RS05420
uniprot id: W8PL36
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

195522:BD01 RS00875
gene id: 195522:BD01_RS00875
uniprot id: W8NZE5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

195522:BD01 RS03905
gene id: 195522:BD01_RS03905
uniprot id: W8PK17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

195522:BD01 RS08960
gene id: 195522:BD01_RS08960
uniprot id: W8P3U6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

195522:BD01 RS08330
gene id: 195522:BD01_RS08330
uniprot id: W8P719
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

195522:BD01 RS05860
gene id: 195522:BD01_RS05860
uniprot id: W8NU98
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

195522:BD01 RS06465
gene id: 195522:BD01_RS06465
uniprot id: W8NUK3
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS10420
gene id: 195522:BD01_RS10420
uniprot id: W8NWU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

195522:BD01 RS04550
gene id: 195522:BD01_RS04550
uniprot id: W8P1D0
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

195522:BD01 RS10380
gene id: 195522:BD01_RS10380
uniprot id: W8P885
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

195522:BD01 RS07265
gene id: 195522:BD01_RS07265
uniprot id: W8NVA2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

195522:BD01 RS01190
gene id: 195522:BD01_RS01190
uniprot id: W8NRM5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

195522:BD01 RS10020
gene id: 195522:BD01_RS10020
uniprot id: W8PNP5
names: Subcellular Location Annotation
messages: Nucleus

195522:BD01 RS01685
gene id: 195522:BD01_RS01685
uniprot id: W8PIM6
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS01140
gene id: 195522:BD01_RS01140
uniprot id: W8NRL7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS04745
gene id: 195522:BD01_RS04745
uniprot id: W8NTY3
names: Similarity
messages: Belongs to the IMPACT family.

195522:BD01 RS02315
gene id: 195522:BD01_RS02315
uniprot id: W8PJ14
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

195522:BD01 RS01710
gene id: 195522:BD01_RS01710
uniprot id: W8NRX0
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

195522:BD01 RS03260
gene id: 195522:BD01_RS03260
uniprot id: W8NT65
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

195522:BD01 RS04530
gene id: 195522:BD01_RS04530
uniprot id: W8NTU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

195522:BD01 RS09805
gene id: 195522:BD01_RS09805
uniprot id: W8NWF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

195522:BD01 RS05170
gene id: 195522:BD01_RS05170
uniprot id: W8P5F5
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

195522:BD01 RS02435
gene id: 195522:BD01_RS02435
uniprot id: W8P074
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

195522:BD01 RS02720
gene id: 195522:BD01_RS02720
uniprot id: W8P0D6
names: Similarity
messages: Belongs to the peptidase U62 family.

195522:BD01 RS00980
gene id: 195522:BD01_RS00980
uniprot id: W8NRW3
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS10460
gene id: 195522:BD01_RS10460
uniprot id: W8P4N2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

195522:BD01 RS07130
gene id: 195522:BD01_RS07130
uniprot id: W8NUX4
names: Similarity
messages: Belongs to the UDPGP type 2 family.

195522:BD01 RS01610
gene id: 195522:BD01_RS01610
uniprot id: W8PIL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

195522:BD01 RS02000
gene id: 195522:BD01_RS02000
uniprot id: W8NZY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

195522:BD01 RS10745
gene id: 195522:BD01_RS10745
uniprot id: W8P8D9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

195522:BD01 RS07665
gene id: 195522:BD01_RS07665
uniprot id: W8P334
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

195522:BD01 RS00730
gene id: 195522:BD01_RS00730
uniprot id: W8NRR5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP-dependent glucokinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate.
messages: Cytoplasm

195522:BD01 RS08425
gene id: 195522:BD01_RS08425
uniprot id: W8PMT9
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

195522:BD01 RS04445
gene id: 195522:BD01_RS04445
uniprot id: W8PKD8
names: Similarity
messages: Belongs to the DEAD box helicase family.

195522:BD01 RS01360
gene id: 195522:BD01_RS01360
uniprot id: W8NRQ7
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

195522:BD01 RS04590
gene id: 195522:BD01_RS04590
uniprot id: W8PKG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

195522:BD01 RS03510
gene id: 195522:BD01_RS03510
uniprot id: W8NTA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

195522:BD01 RS03605
gene id: 195522:BD01_RS03605
uniprot id: W8P4I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

195522:BD01 RS07135
gene id: 195522:BD01_RS07135
uniprot id: W8PLZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

195522:BD01 RS01440
gene id: 195522:BD01_RS01440
uniprot id: W8PIH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

195522:BD01 RS02615
gene id: 195522:BD01_RS02615
uniprot id: W8P414
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

195522:BD01 RS01525
gene id: 195522:BD01_RS01525
uniprot id: W8NS63
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS06030
gene id: 195522:BD01_RS06030
uniprot id: W8NUC5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

195522:BD01 RS09595
gene id: 195522:BD01_RS09595
uniprot id: W8NWK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

195522:BD01 RS02770
gene id: 195522:BD01_RS02770
uniprot id: W8P0E6
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

195522:BD01 RS00180
gene id: 195522:BD01_RS00180
uniprot id: W8NRB5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS00300
gene id: 195522:BD01_RS00300
uniprot id: W8P2Q7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

195522:BD01 RS00340
gene id: 195522:BD01_RS00340
uniprot id: W8NR88
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

195522:BD01 RS08365
gene id: 195522:BD01_RS08365
uniprot id: W8NVZ5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

195522:BD01 RS09840
gene id: 195522:BD01_RS09840
uniprot id: W8P7V2
names: Similarity
messages: Belongs to the HepT RNase toxin family.

195522:BD01 RS06815
gene id: 195522:BD01_RS06815
uniprot id: W8P677
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

195522:BD01 RS07905
gene id: 195522:BD01_RS07905
uniprot id: W8PMI5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

195522:BD01 RS00815
gene id: 195522:BD01_RS00815
uniprot id: W8PI68
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS01410
gene id: 195522:BD01_RS01410
uniprot id: W8NRR6
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

195522:BD01 RS00935
gene id: 195522:BD01_RS00935
uniprot id: W8NRI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

195522:BD01 RS04805
gene id: 195522:BD01_RS04805
uniprot id: W8NTM8
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS00800
gene id: 195522:BD01_RS00800
uniprot id: W8NZD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

195522:BD01 RS09365
gene id: 195522:BD01_RS09365
uniprot id: W8NW76
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

195522:BD01 RS00680
gene id: 195522:BD01_RS00680
uniprot id: W8NRQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

195522:BD01 RS10690
gene id: 195522:BD01_RS10690
uniprot id: W8P4S0
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

195522:BD01 RS01090
gene id: 195522:BD01_RS01090
uniprot id: W8NRK8
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

195522:BD01 RS05220
gene id: 195522:BD01_RS05220
uniprot id: W8NU03
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

195522:BD01 RS06425
gene id: 195522:BD01_RS06425
uniprot id: W8P602
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

195522:BD01 RS10390
gene id: 195522:BD01_RS10390
uniprot id: W8NX40
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

195522:BD01 RS08430
gene id: 195522:BD01_RS08430
uniprot id: W8P736
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS02010
gene id: 195522:BD01_RS02010
uniprot id: W8NS16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

195522:BD01 RS08060
gene id: 195522:BD01_RS08060
uniprot id: W8NVJ1
names: Similarity
messages: Belongs to the UPF0200 family.

195522:BD01 RS01390
gene id: 195522:BD01_RS01390
uniprot id: W8PIG2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

195522:BD01 RS08495
gene id: 195522:BD01_RS08495
uniprot id: W8PMV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

195522:BD01 RS00230
gene id: 195522:BD01_RS00230
uniprot id: W8NZ07
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

195522:BD01 RS07250
gene id: 195522:BD01_RS07250
uniprot id: W8PM19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

195522:BD01 RS03345
gene id: 195522:BD01_RS03345
uniprot id: W8PJQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

195522:BD01 RS03205
gene id: 195522:BD01_RS03205
uniprot id: W8P0Q8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

195522:BD01 RS03120
gene id: 195522:BD01_RS03120
uniprot id: W8NT40
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

195522:BD01 RS06630
gene id: 195522:BD01_RS06630
uniprot id: W8NUN5
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

195522:BD01 RS09275
gene id: 195522:BD01_RS09275
uniprot id: W8P7H5
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

195522:BD01 RS09795
gene id: 195522:BD01_RS09795
uniprot id: W8P486
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

195522:BD01 RS02610
gene id: 195522:BD01_RS02610
uniprot id: W8PJ76
names: Similarity
messages: Belongs to the NodU/CmcH family.

195522:BD01 RS10435
gene id: 195522:BD01_RS10435
uniprot id: W8P4M8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

195522:BD01 RS10890
gene id: 195522:BD01_RS10890
uniprot id: W8P8F9
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

195522:BD01 RS10370
gene id: 195522:BD01_RS10370
uniprot id: W8NWT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

195522:BD01 RS02475
gene id: 195522:BD01_RS02475
uniprot id: W8PJ50
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

195522:BD01 RS07240
gene id: 195522:BD01_RS07240
uniprot id: W8NV99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

195522:BD01 RS08380
gene id: 195522:BD01_RS08380
uniprot id: W8P726
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

195522:BD01 RS04275
gene id: 195522:BD01_RS04275
uniprot id: W8P188
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

195522:BD01 RS06150
gene id: 195522:BD01_RS06150
uniprot id: W8PLG5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

195522:BD01 RS04050
gene id: 195522:BD01_RS04050
uniprot id: W8PK53
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

195522:BD01 RS02065
gene id: 195522:BD01_RS02065
uniprot id: W8NS27
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

195522:BD01 RS08115
gene id: 195522:BD01_RS08115
uniprot id: W8PMM5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

195522:BD01 RS00995
gene id: 195522:BD01_RS00995
uniprot id: W8NRJ1
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.

195522:BD01 RS09335
gene id: 195522:BD01_RS09335
uniprot id: W8NWF7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

195522:BD01 RS05515
gene id: 195522:BD01_RS05515
uniprot id: W8PL55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

195522:BD01 RS02635
gene id: 195522:BD01_RS02635
uniprot id: W8PJ81
names: Similarity
messages: Belongs to the UPF0166 family.

195522:BD01 RS01395
gene id: 195522:BD01_RS01395
uniprot id: W8P3B7
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS04585
gene id: 195522:BD01_RS04585
uniprot id: W8NTI4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

195522:BD01 RS10470
gene id: 195522:BD01_RS10470
uniprot id: W8NWU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

195522:BD01 RS02490
gene id: 195522:BD01_RS02490
uniprot id: W8NSP1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

195522:BD01 RS00835
gene id: 195522:BD01_RS00835
uniprot id: W8NRH0
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

195522:BD01 RS03950
gene id: 195522:BD01_RS03950
uniprot id: W8PK29
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

195522:BD01 RS03085
gene id: 195522:BD01_RS03085
uniprot id: W8P4B0
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

195522:BD01 RS11110
gene id: 195522:BD01_RS11110
uniprot id: W8P4K3
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

195522:BD01 RS05930
gene id: 195522:BD01_RS05930
uniprot id: W8NUM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

195522:BD01 RS10515
gene id: 195522:BD01_RS10515
uniprot id: W8NX62
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

195522:BD01 RS03570
gene id: 195522:BD01_RS03570
uniprot id: W8NSZ2
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

195522:BD01 RS10050
gene id: 195522:BD01_RS10050
uniprot id: W8P7Z6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

195522:BD01 RS10620
gene id: 195522:BD01_RS10620
uniprot id: W8P8C2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

195522:BD01 RS01195
gene id: 195522:BD01_RS01195
uniprot id: W8PIC6
names: Function
messages: Probably involved in the biogenesis of the ribosome.

195522:BD01 RS08395
gene id: 195522:BD01_RS08395
uniprot id: W8NVP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

195522:BD01 RS01480
gene id: 195522:BD01_RS01480
uniprot id: W8NS54
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

195522:BD01 RS07375
gene id: 195522:BD01_RS07375
uniprot id: W8P2W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

195522:BD01 RS08760
gene id: 195522:BD01_RS08760
uniprot id: W8PN07
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

195522:BD01 RS09815
gene id: 195522:BD01_RS09815
uniprot id: W8P7U7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

195522:BD01 RS00805
gene id: 195522:BD01_RS00805
uniprot id: W8NRS8
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS01150
gene id: 195522:BD01_RS01150
uniprot id: W8P369
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

195522:BD01 RS09400
gene id: 195522:BD01_RS09400
uniprot id: W8P7K4
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

195522:BD01 RS09330
gene id: 195522:BD01_RS09330
uniprot id: W8P407
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

195522:BD01 RS06400
gene id: 195522:BD01_RS06400
uniprot id: W8P5Z6
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS01605
gene id: 195522:BD01_RS01605
uniprot id: W8NRV4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

195522:BD01 RS10915
gene id: 195522:BD01_RS10915
uniprot id: W8P4V8
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

195522:BD01 RS06680
gene id: 195522:BD01_RS06680
uniprot id: W8NUP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

195522:BD01 RS04260
gene id: 195522:BD01_RS04260
uniprot id: W8NTC2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

195522:BD01 RS06730
gene id: 195522:BD01_RS06730
uniprot id: W8NUQ1
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

195522:BD01 RS09800
gene id: 195522:BD01_RS09800
uniprot id: W8NWP2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

195522:BD01 RS09945
gene id: 195522:BD01_RS09945
uniprot id: W8PNM5
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

195522:BD01 RS10025
gene id: 195522:BD01_RS10025
uniprot id: W8P7Z0
names: Similarity
messages: Belongs to the MCM family.

195522:BD01 RS08050
gene id: 195522:BD01_RS08050
uniprot id: W8P3D6
names: Similarity
messages: Belongs to the UPF0201 family.

195522:BD01 RS10555
gene id: 195522:BD01_RS10555
uniprot id: W8P8B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

195522:BD01 RS07625
gene id: 195522:BD01_RS07625
uniprot id: W8PM92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

195522:BD01 RS03155
gene id: 195522:BD01_RS03155
uniprot id: W8P4B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

195522:BD01 RS03640
gene id: 195522:BD01_RS03640
uniprot id: W8NT05
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

195522:BD01 RS01055
gene id: 195522:BD01_RS01055
uniprot id: W8NZH4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

195522:BD01 RS10560
gene id: 195522:BD01_RS10560
uniprot id: W8P4P9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

195522:BD01 RS03600
gene id: 195522:BD01_RS03600
uniprot id: W8PJV0
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

195522:BD01 RS03970
gene id: 195522:BD01_RS03970
uniprot id: W8NT75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

195522:BD01 RS00225
gene id: 195522:BD01_RS00225
uniprot id: W8P2P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

195522:BD01 RS09415
gene id: 195522:BD01_RS09415
uniprot id: W8NW83
names: Similarity
messages: Belongs to the CutA family.

195522:BD01 RS09185
gene id: 195522:BD01_RS09185
uniprot id: W8NWC7
names: Similarity
messages: Belongs to the UPF0111 family.

195522:BD01 RS05145
gene id: 195522:BD01_RS05145
uniprot id: W8P5F1
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS02955
gene id: 195522:BD01_RS02955
uniprot id: W8NSP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

195522:BD01 RS10270
gene id: 195522:BD01_RS10270
uniprot id: W8P869
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

195522:BD01 RS03435
gene id: 195522:BD01_RS03435
uniprot id: W8NT95
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

195522:BD01 RS03685
gene id: 195522:BD01_RS03685
uniprot id: W8NTD1
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS00405
gene id: 195522:BD01_RS00405
uniprot id: W8NZ72
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

195522:BD01 RS08210
gene id: 195522:BD01_RS08210
uniprot id: W8PMP4
names: Similarity
messages: Belongs to the UPF0173 family.

195522:BD01 RS08255
gene id: 195522:BD01_RS08255
uniprot id: W8NVL9
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

195522:BD01 RS10720
gene id: 195522:BD01_RS10720
uniprot id: W8P8D7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
messages: Cytoplasm

195522:BD01 RS10430
gene id: 195522:BD01_RS10430
uniprot id: W8P893
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

195522:BD01 RS05545
gene id: 195522:BD01_RS05545
uniprot id: W8P5M2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

195522:BD01 RS06290
gene id: 195522:BD01_RS06290
uniprot id: W8NUH2
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

195522:BD01 RS06010
gene id: 195522:BD01_RS06010
uniprot id: W8PLE6
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

195522:BD01 RS07725
gene id: 195522:BD01_RS07725
uniprot id: W8NVD3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

195522:BD01 RS06185
gene id: 195522:BD01_RS06185
uniprot id: W8P5W2
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

195522:BD01 RS02040
gene id: 195522:BD01_RS02040
uniprot id: W8PIV2
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS10015
gene id: 195522:BD01_RS10015
uniprot id: W8NWK1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

195522:BD01 RS01640
gene id: 195522:BD01_RS01640
uniprot id: W8P3G9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS00145
gene id: 195522:BD01_RS00145
uniprot id: W8PHR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

195522:BD01 RS05405
gene id: 195522:BD01_RS05405
uniprot id: W8P5K2
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

195522:BD01 RS01310
gene id: 195522:BD01_RS01310
uniprot id: W8NRP8
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS02675
gene id: 195522:BD01_RS02675
uniprot id: W8NST4
names: Similarity
messages: Belongs to the pyruvate kinase family.

195522:BD01 RS01555
gene id: 195522:BD01_RS01555
uniprot id: W8NRU5
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.
messages: Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif).
messages: DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS07715
gene id: 195522:BD01_RS07715
uniprot id: W8P361
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS01160
gene id: 195522:BD01_RS01160
uniprot id: W8NRZ2
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

195522:BD01 RS01330
gene id: 195522:BD01_RS01330
uniprot id: W8NS22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

195522:BD01 RS04465
gene id: 195522:BD01_RS04465
uniprot id: W8NTT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

195522:BD01 RS01945
gene id: 195522:BD01_RS01945
uniprot id: W8P3N0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

195522:BD01 RS00535
gene id: 195522:BD01_RS00535
uniprot id: W8NRN2
names: Similarity
messages: Belongs to the HypE family.

195522:BD01 RS10405
gene id: 195522:BD01_RS10405
uniprot id: W8P888
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

195522:BD01 RS06720
gene id: 195522:BD01_RS06720
uniprot id: W8P2J0
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

195522:BD01 RS00430
gene id: 195522:BD01_RS00430
uniprot id: W8NZ77
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

195522:BD01 RS08095
gene id: 195522:BD01_RS08095
uniprot id: W8P6Z0
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

195522:BD01 RS08515
gene id: 195522:BD01_RS08515
uniprot id: W8PMV9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

195522:BD01 RS10355
gene id: 195522:BD01_RS10355
uniprot id: W8P4L6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

195522:BD01 RS10730
gene id: 195522:BD01_RS10730
uniprot id: W8NX97
names: Similarity
messages: Belongs to the MEMO1 family.

195522:BD01 RS02465
gene id: 195522:BD01_RS02465
uniprot id: W8NSN6
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

195522:BD01 RS06850
gene id: 195522:BD01_RS06850
uniprot id: W8NV32
names: Similarity
messages: Belongs to the UPF0216 family.

195522:BD01 RS02815
gene id: 195522:BD01_RS02815
uniprot id: W8P469
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

195522:BD01 RS09285
gene id: 195522:BD01_RS09285
uniprot id: W8NWE7
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

195522:BD01 RS04945
gene id: 195522:BD01_RS04945
uniprot id: W8P1L0
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS03200
gene id: 195522:BD01_RS03200
uniprot id: W8P4C6
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS08370
gene id: 195522:BD01_RS08370
uniprot id: W8NVN8
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

195522:BD01 RS02965
gene id: 195522:BD01_RS02965
uniprot id: W8P491
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

195522:BD01 RS04545
gene id: 195522:BD01_RS04545
uniprot id: W8P532
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

195522:BD01 RS04975
gene id: 195522:BD01_RS04975
uniprot id: W8NU33
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

195522:BD01 RS10495
gene id: 195522:BD01_RS10495
uniprot id: W8NWV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

195522:BD01 RS06140
gene id: 195522:BD01_RS06140
uniprot id: W8NUQ3
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

195522:BD01 RS09140
gene id: 195522:BD01_RS09140
uniprot id: W8NW35
names: Similarity
messages: Belongs to the FrhG family.

195522:BD01 RS01075
gene id: 195522:BD01_RS01075
uniprot id: W8P357
names: Similarity
messages: Belongs to the arginase family.

195522:BD01 RS03750
gene id: 195522:BD01_RS03750
uniprot id: W8NT28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

195522:BD01 RS02775
gene id: 195522:BD01_RS02775
uniprot id: W8NSV6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

195522:BD01 RS08785
gene id: 195522:BD01_RS08785
uniprot id: W8PN10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

195522:BD01 RS05895
gene id: 195522:BD01_RS05895
uniprot id: W8P5S3
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

195522:BD01 RS02750
gene id: 195522:BD01_RS02750
uniprot id: W8P0E2
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

195522:BD01 RS01755
gene id: 195522:BD01_RS01755
uniprot id: W8NSA6
names: Similarity
messages: Belongs to the UPF0212 family.

195522:BD01 RS04650
gene id: 195522:BD01_RS04650
uniprot id: W8P1E7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

195522:BD01 RS09420
gene id: 195522:BD01_RS09420
uniprot id: W8PNC2
names: Similarity
messages: Belongs to the UPF0215 family.

195522:BD01 RS03630
gene id: 195522:BD01_RS03630
uniprot id: W8P0X8
names: Similarity
messages: Belongs to the UPF0235 family.

195522:BD01 RS03140
gene id: 195522:BD01_RS03140
uniprot id: W8P0P6
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

195522:BD01 RS02595
gene id: 195522:BD01_RS02595
uniprot id: W8P0B3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

195522:BD01 RS09345
gene id: 195522:BD01_RS09345
uniprot id: W8PNB1
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

195522:BD01 RS10820
gene id: 195522:BD01_RS10820
uniprot id: W8P8F0
names: Similarity
messages: Belongs to the peptidase M24B family.

195522:BD01 RS06235
gene id: 195522:BD01_RS06235
uniprot id: W8P5W9
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

195522:BD01 RS05855
gene id: 195522:BD01_RS05855
uniprot id: W8NUL6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

195522:BD01 RS10485
gene id: 195522:BD01_RS10485
uniprot id: W8P4N6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

195522:BD01 RS03865
gene id: 195522:BD01_RS03865
uniprot id: W8NT52
names: Cofactor
messages: Binds 1 zinc ion per subunit.

195522:BD01 RS03565
gene id: 195522:BD01_RS03565
uniprot id: W8NTB4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

195522:BD01 RS03405
gene id: 195522:BD01_RS03405
uniprot id: W8P0U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

195522:BD01 RS07775
gene id: 195522:BD01_RS07775
uniprot id: W8NVE0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

195522:BD01 RS00600
gene id: 195522:BD01_RS00600
uniprot id: W8P2Y9
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS01950
gene id: 195522:BD01_RS01950
uniprot id: W8NZX2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

195522:BD01 RS02620
gene id: 195522:BD01_RS02620
uniprot id: W8P0B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

195522:BD01 RS02030
gene id: 195522:BD01_RS02030
uniprot id: W8NSF8
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS09290
gene id: 195522:BD01_RS09290
uniprot id: W8NW62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

195522:BD01 RS10590
gene id: 195522:BD01_RS10590
uniprot id: W8P4Q3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

195522:BD01 RS08680
gene id: 195522:BD01_RS08680
uniprot id: W8NVV1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS08705
gene id: 195522:BD01_RS08705
uniprot id: W8NVV5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS09040
gene id: 195522:BD01_RS09040
uniprot id: W8NW17
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS09315
gene id: 195522:BD01_RS09315
uniprot id: W8NW67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

195522:BD01 RS09995
gene id: 195522:BD01_RS09995
uniprot id: W8PNN7
names: Similarity
messages: Belongs to the UPF0175 family.

195522:BD01 RS10860
gene id: 195522:BD01_RS10860
uniprot id: W8PP89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

195522:BD01 RS08885
gene id: 195522:BD01_RS08885
uniprot id: W8PN32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

195522:BD01 RS00630
gene id: 195522:BD01_RS00630
uniprot id: W8NZA7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

195522:BD01 RS09430
gene id: 195522:BD01_RS09430
uniprot id: W8P427
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

195522:BD01 RS08715
gene id: 195522:BD01_RS08715
uniprot id: W8P784
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

195522:BD01 RS07710
gene id: 195522:BD01_RS07710
uniprot id: W8P6S0
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

195522:BD01 RS10155
gene id: 195522:BD01_RS10155
uniprot id: W8NWZ0
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

195522:BD01 RS10115
gene id: 195522:BD01_RS10115
uniprot id: W8NWM6
names: Similarity
messages: Belongs to the SDO1/SBDS family.

195522:BD01 RS01895
gene id: 195522:BD01_RS01895
uniprot id: W8P3M1
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

195522:BD01 RS08850
gene id: 195522:BD01_RS08850
uniprot id: W8NW78
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

195522:BD01 RS10340
gene id: 195522:BD01_RS10340
uniprot id: W8NWS6
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS07270
gene id: 195522:BD01_RS07270
uniprot id: W8NV03
names: Similarity
messages: Belongs to the peptidase S8 family.

195522:BD01 RS06660
gene id: 195522:BD01_RS06660
uniprot id: W8PLR5
names: Similarity
messages: Belongs to the UPF0273 family.

195522:BD01 RS07280
gene id: 195522:BD01_RS07280
uniprot id: W8P2U1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

195522:BD01 RS07900
gene id: 195522:BD01_RS07900
uniprot id: W8NVG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

195522:BD01 RS00910
gene id: 195522:BD01_RS00910
uniprot id: W8NRI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

195522:BD01 RS08055
gene id: 195522:BD01_RS08055
uniprot id: W8NVT9
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS00660
gene id: 195522:BD01_RS00660
uniprot id: W8NRE6
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

195522:BD01 RS04960
gene id: 195522:BD01_RS04960
uniprot id: W8PKN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

195522:BD01 RS00925
gene id: 195522:BD01_RS00925
uniprot id: W8NZF3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

195522:BD01 RS08580
gene id: 195522:BD01_RS08580
uniprot id: W8NW34
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS04625
gene id: 195522:BD01_RS04625
uniprot id: W8P1E1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

195522:BD01 RS10610
gene id: 195522:BD01_RS10610
uniprot id: W8PP44
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

195522:BD01 RS09245
gene id: 195522:BD01_RS09245
uniprot id: W8PN98
names: Similarity
messages: Belongs to the malic enzymes family.

195522:BD01 RS09950
gene id: 195522:BD01_RS09950
uniprot id: W8P7X5
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.

195522:BD01 RS02330
gene id: 195522:BD01_RS02330
uniprot id: W8NSK7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

195522:BD01 RS06795
gene id: 195522:BD01_RS06795
uniprot id: W8P2K2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

195522:BD01 RS09255
gene id: 195522:BD01_RS09255
uniprot id: W8P3Z5
names: Similarity
messages: Belongs to the class-I fumarase family.

195522:BD01 RS06700
gene id: 195522:BD01_RS06700
uniprot id: W8NV05
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS02835
gene id: 195522:BD01_RS02835
uniprot id: W8PJF9
names: Similarity
messages: Belongs to the UPF0284 family.

195522:BD01 RS06610
gene id: 195522:BD01_RS06610
uniprot id: W8PLQ5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

195522:BD01 RS10375
gene id: 195522:BD01_RS10375
uniprot id: W8PP03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

195522:BD01 RS03090
gene id: 195522:BD01_RS03090
uniprot id: W8P0N8
names: Similarity
messages: Belongs to the HerA family.

195522:BD01 RS02495
gene id: 195522:BD01_RS02495
uniprot id: W8NSC3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS10830
gene id: 195522:BD01_RS10830
uniprot id: W8NXB5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

195522:BD01 RS03575
gene id: 195522:BD01_RS03575
uniprot id: W8PJU6
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS09525
gene id: 195522:BD01_RS09525
uniprot id: W8NW99
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

195522:BD01 RS03360
gene id: 195522:BD01_RS03360
uniprot id: W8NT83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

195522:BD01 RS06470
gene id: 195522:BD01_RS06470
uniprot id: W8PLM3
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

195522:BD01 RS08215
gene id: 195522:BD01_RS08215
uniprot id: W8P705
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

195522:BD01 RS02680
gene id: 195522:BD01_RS02680
uniprot id: W8NSG0
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

195522:BD01 RS03840
gene id: 195522:BD01_RS03840
uniprot id: W8NTH1
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

195522:BD01 RS10110
gene id: 195522:BD01_RS10110
uniprot id: W8NWV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

195522:BD01 RS02530
gene id: 195522:BD01_RS02530
uniprot id: W8NSQ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

195522:BD01 RS09715
gene id: 195522:BD01_RS09715
uniprot id: W8P7S3
names: Similarity
messages: Belongs to the UPF0145 family.

195522:BD01 RS07045
gene id: 195522:BD01_RS07045
uniprot id: W8P2P9
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

195522:BD01 RS03930
gene id: 195522:BD01_RS03930
uniprot id: W8PK23
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

195522:BD01 RS04035
gene id: 195522:BD01_RS04035
uniprot id: W8P146
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS06780
gene id: 195522:BD01_RS06780
uniprot id: W8NUQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

195522:BD01 RS08435
gene id: 195522:BD01_RS08435
uniprot id: W8P3K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

195522:BD01 RS04060
gene id: 195522:BD01_RS04060
uniprot id: W8P150
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

195522:BD01 RS01005
gene id: 195522:BD01_RS01005
uniprot id: W8P348
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

195522:BD01 RS02640
gene id: 195522:BD01_RS02640
uniprot id: W8P419
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

195522:BD01 RS03985
gene id: 195522:BD01_RS03985
uniprot id: W8P138
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

195522:BD01 RS04655
gene id: 195522:BD01_RS04655
uniprot id: W8NTW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

195522:BD01 RS01370
gene id: 195522:BD01_RS01370
uniprot id: W8P3B2
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS03050
gene id: 195522:BD01_RS03050
uniprot id: W8NT26
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS05585
gene id: 195522:BD01_RS05585
uniprot id: W8NU56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

195522:BD01 RS06740
gene id: 195522:BD01_RS06740
uniprot id: W8P664
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

195522:BD01 RS01505
gene id: 195522:BD01_RS01505
uniprot id: W8NS59
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

195522:BD01 RS07680
gene id: 195522:BD01_RS07680
uniprot id: W8PMA3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

195522:BD01 RS02900
gene id: 195522:BD01_RS02900
uniprot id: W8P482
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

195522:BD01 RS04045
gene id: 195522:BD01_RS04045
uniprot id: W8NT88
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

195522:BD01 RS10400
gene id: 195522:BD01_RS10400
uniprot id: W8PP09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

195522:BD01 RS03770
gene id: 195522:BD01_RS03770
uniprot id: W8NT32
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

195522:BD01 RS05815
gene id: 195522:BD01_RS05815
uniprot id: W8PLB0
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

195522:BD01 RS10850
gene id: 195522:BD01_RS10850
uniprot id: W8NXB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

195522:BD01 RS04015
gene id: 195522:BD01_RS04015
uniprot id: W8NTK7
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS01690
gene id: 195522:BD01_RS01690
uniprot id: W8P3H9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

195522:BD01 RS02920
gene id: 195522:BD01_RS02920
uniprot id: W8P485
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

195522:BD01 RS06725
gene id: 195522:BD01_RS06725
uniprot id: W8NV10
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

195522:BD01 RS08945
gene id: 195522:BD01_RS08945
uniprot id: W8NW87
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

195522:BD01 RS04785
gene id: 195522:BD01_RS04785
uniprot id: W8PKJ9
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

195522:BD01 RS06925
gene id: 195522:BD01_RS06925
uniprot id: W8NV47
names: Similarity
messages: Belongs to the UPF0146 family.

195522:BD01 RS08320
gene id: 195522:BD01_RS08320
uniprot id: W8NVM9
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

195522:BD01 RS04135
gene id: 195522:BD01_RS04135
uniprot id: W8P163
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

195522:BD01 RS03395
gene id: 195522:BD01_RS03395
uniprot id: W8PJR6
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS09745
gene id: 195522:BD01_RS09745
uniprot id: W8P478
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

195522:BD01 RS09360
gene id: 195522:BD01_RS09360
uniprot id: W8NWG1
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

195522:BD01 RS04895
gene id: 195522:BD01_RS04895
uniprot id: W8P1J8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

195522:BD01 RS10475
gene id: 195522:BD01_RS10475
uniprot id: W8PP21
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

195522:BD01 RS00270
gene id: 195522:BD01_RS00270
uniprot id: W8PHT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

195522:BD01 RS03230
gene id: 195522:BD01_RS03230
uniprot id: W8P0R1
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS03645
gene id: 195522:BD01_RS03645
uniprot id: W8PJV8
names: Similarity
messages: Belongs to the CinA family.

195522:BD01 RS01155
gene id: 195522:BD01_RS01155
uniprot id: W8NZI7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

195522:BD01 RS06705
gene id: 195522:BD01_RS06705
uniprot id: W8NUP6
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

195522:BD01 RS05920
gene id: 195522:BD01_RS05920
uniprot id: W8P5S5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

195522:BD01 RS04185
gene id: 195522:BD01_RS04185
uniprot id: W8P171
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

195522:BD01 RS00205
gene id: 195522:BD01_RS00205
uniprot id: W8NZ03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

195522:BD01 RS03095
gene id: 195522:BD01_RS03095
uniprot id: W8NT36
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

195522:BD01 RS06635
gene id: 195522:BD01_RS06635
uniprot id: W8PLR0
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

195522:BD01 RS03255
gene id: 195522:BD01_RS03255
uniprot id: W8P0R6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

195522:BD01 RS06565
gene id: 195522:BD01_RS06565
uniprot id: W8PLP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

195522:BD01 RS10755
gene id: 195522:BD01_RS10755
uniprot id: W8NXA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS03045
gene id: 195522:BD01_RS03045
uniprot id: W8P0M9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-64 and Arg-67) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

195522:BD01 RS07245
gene id: 195522:BD01_RS07245
uniprot id: W8NUZ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

195522:BD01 RS08125
gene id: 195522:BD01_RS08125
uniprot id: W8P3E9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

195522:BD01 RS01335
gene id: 195522:BD01_RS01335
uniprot id: W8NRQ3
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS10770
gene id: 195522:BD01_RS10770
uniprot id: W8P8E2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

195522:BD01 RS10530
gene id: 195522:BD01_RS10530
uniprot id: W8P8B0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

195522:BD01 RS05230
gene id: 195522:BD01_RS05230
uniprot id: W8P5I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

195522:BD01 RS09490
gene id: 195522:BD01_RS09490
uniprot id: W8NWI7
names: Similarity
messages: Belongs to the UPF0175 family.

195522:BD01 RS03725
gene id: 195522:BD01_RS03725
uniprot id: W8NT23
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS05995
gene id: 195522:BD01_RS05995
uniprot id: W8P274
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

195522:BD01 RS03870
gene id: 195522:BD01_RS03870
uniprot id: W8NTI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

195522:BD01 RS09530
gene id: 195522:BD01_RS09530
uniprot id: W8PNE0
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

195522:BD01 RS04365
gene id: 195522:BD01_RS04365
uniprot id: W8P4Z8
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

195522:BD01 RS01740
gene id: 195522:BD01_RS01740
uniprot id: W8PIN7
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

195522:BD01 RS06315
gene id: 195522:BD01_RS06315
uniprot id: W8NUH6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

195522:BD01 RS01580
gene id: 195522:BD01_RS01580
uniprot id: W8NRU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

195522:BD01 RS01350
gene id: 195522:BD01_RS01350
uniprot id: W8NZM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

195522:BD01 RS10480
gene id: 195522:BD01_RS10480
uniprot id: W8P8A2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

195522:BD01 RS00555
gene id: 195522:BD01_RS00555
uniprot id: W8NZ96
names: Similarity
messages: Belongs to the HypD family.

195522:BD01 RS01625
gene id: 195522:BD01_RS01625
uniprot id: W8NS81
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS04705
gene id: 195522:BD01_RS04705
uniprot id: W8PKI9
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

195522:BD01 RS01450
gene id: 195522:BD01_RS01450
uniprot id: W8NZN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

195522:BD01 RS10190
gene id: 195522:BD01_RS10190
uniprot id: W8PNX2
names: Similarity
messages: Belongs to the thioesterase PaaI family.

195522:BD01 RS07300
gene id: 195522:BD01_RS07300
uniprot id: W8P6H2
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS02565
gene id: 195522:BD01_RS02565
uniprot id: W8P403
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

195522:BD01 RS02970
gene id: 195522:BD01_RS02970
uniprot id: W8P0L6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

195522:BD01 RS04100
gene id: 195522:BD01_RS04100
uniprot id: W8PK64
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

195522:BD01 RS06875
gene id: 195522:BD01_RS06875
uniprot id: W8NV37
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

195522:BD01 RS10425
gene id: 195522:BD01_RS10425
uniprot id: W8PP14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

195522:BD01 RS09610
gene id: 195522:BD01_RS09610
uniprot id: W8P7Q2
names: Similarity
messages: Belongs to the AOR/FOR family.

195522:BD01 RS01495
gene id: 195522:BD01_RS01495
uniprot id: W8P3D7
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

195522:BD01 RS04195
gene id: 195522:BD01_RS04195
uniprot id: W8PK82
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

195522:BD01 RS08225
gene id: 195522:BD01_RS08225
uniprot id: W8NVX0
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

195522:BD01 RS05165
gene id: 195522:BD01_RS05165
uniprot id: W8PKT8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

195522:BD01 RS00550
gene id: 195522:BD01_RS00550
uniprot id: W8P2Y1
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

195522:BD01 RS09905
gene id: 195522:BD01_RS09905
uniprot id: W8P4B1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

195522:BD01 RS03850
gene id: 195522:BD01_RS03850
uniprot id: W8PK03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

195522:BD01 RS07605
gene id: 195522:BD01_RS07605
uniprot id: W8P6N4
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

195522:BD01 RS03535
gene id: 195522:BD01_RS03535
uniprot id: W8P0W0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

195522:BD01 RS10440
gene id: 195522:BD01_RS10440
uniprot id: W8NX50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

195522:BD01 RS03400
gene id: 195522:BD01_RS03400
uniprot id: W8P4G0
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

195522:BD01 RS03480
gene id: 195522:BD01_RS03480
uniprot id: W8P0V2
names: Similarity
messages: Belongs to the AAA ATPase family.

195522:BD01 RS02710
gene id: 195522:BD01_RS02710
uniprot id: W8PJ96
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

195522:BD01 RS07065
gene id: 195522:BD01_RS07065
uniprot id: W8P6C7
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

195522:BD01 RS10030
gene id: 195522:BD01_RS10030
uniprot id: W8P4E1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

195522:BD01 RS09565
gene id: 195522:BD01_RS09565
uniprot id: W8P447
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS04615
gene id: 195522:BD01_RS04615
uniprot id: W8PKH1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

195522:BD01 RS07790
gene id: 195522:BD01_RS07790
uniprot id: W8P390
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS01660
gene id: 195522:BD01_RS01660
uniprot id: W8PIM1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

195522:BD01 RS01925
gene id: 195522:BD01_RS01925
uniprot id: W8NZW8
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS10395
gene id: 195522:BD01_RS10395
uniprot id: W8NWT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

195522:BD01 RS08865
gene id: 195522:BD01_RS08865
uniprot id: W8P7A3
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS05580
gene id: 195522:BD01_RS05580
uniprot id: W8NUH4
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

195522:BD01 RS00200
gene id: 195522:BD01_RS00200
uniprot id: W8P2N5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

195522:BD01 RS02300
gene id: 195522:BD01_RS02300
uniprot id: W8P041
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

195522:BD01 RS01665
gene id: 195522:BD01_RS01665
uniprot id: W8P3H4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

195522:BD01 RS04380
gene id: 195522:BD01_RS04380
uniprot id: W8NTE3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

195522:BD01 RS03805
gene id: 195522:BD01_RS03805
uniprot id: W8P4M6
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

195522:BD01 RS00830
gene id: 195522:BD01_RS00830
uniprot id: W8NRT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

195522:BD01 RS07925
gene id: 195522:BD01_RS07925
uniprot id: W8NVG7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

195522:BD01 RS02685
gene id: 195522:BD01_RS02685
uniprot id: W8PJ91
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS02915
gene id: 195522:BD01_RS02915
uniprot id: W8NSN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

195522:BD01 RS05225
gene id: 195522:BD01_RS05225
uniprot id: W8PL01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

195522:BD01 RS07560
gene id: 195522:BD01_RS07560
uniprot id: W8P6M3
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

195522:BD01 RS03830
gene id: 195522:BD01_RS03830
uniprot id: W8P4N1
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

195522:BD01 RS02755
gene id: 195522:BD01_RS02755
uniprot id: W8NSH2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

195522:BD01 RS02830
gene id: 195522:BD01_RS02830
uniprot id: W8NSL6
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

195522:BD01 RS04560
gene id: 195522:BD01_RS04560
uniprot id: W8NTH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

195522:BD01 RS10790
gene id: 195522:BD01_RS10790
uniprot id: W8PP77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

195522:BD01 RS05600
gene id: 195522:BD01_RS05600
uniprot id: W8P210
names: Function
names: Similarity
messages: Belongs to the Tfx family.
messages: Putative transcriptional regulator.

195522:BD01 RS07035
gene id: 195522:BD01_RS07035
uniprot id: W8PLY1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

195522:BD01 RS07570
gene id: 195522:BD01_RS07570
uniprot id: W8NV72
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

195522:BD01 RS05595
gene id: 195522:BD01_RS05595
uniprot id: W8P5M8
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS10000
gene id: 195522:BD01_RS10000
uniprot id: W8P7Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

195522:BD01 RS06485
gene id: 195522:BD01_RS06485
uniprot id: W8NUW2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

195522:BD01 RS07910
gene id: 195522:BD01_RS07910
uniprot id: W8P6W3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

195522:BD01 RS09250
gene id: 195522:BD01_RS09250
uniprot id: W8P7G8
names: Similarity
messages: Belongs to the class-I fumarase family.

195522:BD01 RS08135
gene id: 195522:BD01_RS08135
uniprot id: W8NVK3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

195522:BD01 RS09410
gene id: 195522:BD01_RS09410
uniprot id: W8NWH1
names: Similarity
messages: Belongs to the acylphosphatase family.

195522:BD01 RS07600
gene id: 195522:BD01_RS07600
uniprot id: W8PM89
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS10940
gene id: 195522:BD01_RS10940
uniprot id: W8P4W1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

195522:BD01 RS03530
gene id: 195522:BD01_RS03530
uniprot id: W8P4H9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

195522:BD01 RS04535
gene id: 195522:BD01_RS04535
uniprot id: W8NTH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

195522:BD01 RS04600
gene id: 195522:BD01_RS04600
uniprot id: W8P1D9
names: Similarity
messages: Belongs to the UPF0045 family.

195522:BD01 RS04920
gene id: 195522:BD01_RS04920
uniprot id: W8P1K3
names: Similarity
messages: Belongs to the UPF0179 family.

195522:BD01 RS03220
gene id: 195522:BD01_RS03220
uniprot id: W8PJN5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

195522:BD01 RS07515
gene id: 195522:BD01_RS07515
uniprot id: W8NVF8
names: Subunit
messages: Homotetramer.

195522:BD01 RS06550
gene id: 195522:BD01_RS06550
uniprot id: W8P2G3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

195522:BD01 RS05560
gene id: 195522:BD01_RS05560
uniprot id: W8NU53
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

195522:BD01 RS01080
gene id: 195522:BD01_RS01080
uniprot id: W8NZH6
names: Similarity
messages: Belongs to the HPS/KGPDC family. HPS subfamily.
messages: Belongs to the SIS family. PHI subfamily.

195522:BD01 RS08360
gene id: 195522:BD01_RS08360
uniprot id: W8P3J1
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

195522:BD01 RS06940
gene id: 195522:BD01_RS06940
uniprot id: W8P6A4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

195522:BD01 RS05835
gene id: 195522:BD01_RS05835
uniprot id: W8NU94
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

195522:BD01 RS09340
gene id: 195522:BD01_RS09340
uniprot id: W8NW72
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

195522:BD01 RS02210
gene id: 195522:BD01_RS02210
uniprot id: W8NS58
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

195522:BD01 RS07550
gene id: 195522:BD01_RS07550
uniprot id: W8NV67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

195522:BD01 RS06800
gene id: 195522:BD01_RS06800
uniprot id: W8NV23
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

195522:BD01 RS05685
gene id: 195522:BD01_RS05685
uniprot id: W8PL87
names: Similarity
messages: Belongs to the HsdR family.

195522:BD01 RS01200
gene id: 195522:BD01_RS01200
uniprot id: W8P378
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

195522:BD01 RS06965
gene id: 195522:BD01_RS06965
uniprot id: W8P6A9
names: Function
names: Similarity
messages: Belongs to the UPF0330 family.
messages: Possibly the antitoxin component of a toxin-antitoxin (TA) module.

195522:BD01 RS07125
gene id: 195522:BD01_RS07125
uniprot id: W8NV83
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

195522:BD01 RS06560
gene id: 195522:BD01_RS06560
uniprot id: W8NUM2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

195522:BD01 RS01475
gene id: 195522:BD01_RS01475
uniprot id: W8NZP3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

195522:BD01 RS07895
gene id: 195522:BD01_RS07895
uniprot id: W8NVR1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

195522:BD01 RS02525
gene id: 195522:BD01_RS02525
uniprot id: W8PJ58
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

195522:BD01 RS05780
gene id: 195522:BD01_RS05780
uniprot id: W8NUK4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS01650
gene id: 195522:BD01_RS01650
uniprot id: W8NS86
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

195522:BD01 RS02945
gene id: 195522:BD01_RS02945
uniprot id: W8P0L2
names: Caution
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS01510
gene id: 195522:BD01_RS01510
uniprot id: W8NRT5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

195522:BD01 RS07980
gene id: 195522:BD01_RS07980
uniprot id: W8P6X4
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS06845
gene id: 195522:BD01_RS06845
uniprot id: W8P2L2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

195522:BD01 RS05000
gene id: 195522:BD01_RS05000
uniprot id: W8NU39
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

195522:BD01 RS05670
gene id: 195522:BD01_RS05670
uniprot id: W8P220
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

195522:BD01 RS08035
gene id: 195522:BD01_RS08035
uniprot id: W8P3D2
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS08325
gene id: 195522:BD01_RS08325
uniprot id: W8PMS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

195522:BD01 RS10450
gene id: 195522:BD01_RS10450
uniprot id: W8PP19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

195522:BD01 RS06715
gene id: 195522:BD01_RS06715
uniprot id: W8P659
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

195522:BD01 RS01025
gene id: 195522:BD01_RS01025
uniprot id: W8PI96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

195522:BD01 RS04255
gene id: 195522:BD01_RS04255
uniprot id: W8NTQ3
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

195522:BD01 RS06750
gene id: 195522:BD01_RS06750
uniprot id: W8NV13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

195522:BD01 RS10305
gene id: 195522:BD01_RS10305
uniprot id: W8P4K6
names: Similarity
messages: Belongs to the UPF0045 family.

195522:BD01 RS09630
gene id: 195522:BD01_RS09630
uniprot id: W8NWB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

195522:BD01 RS04985
gene id: 195522:BD01_RS04985
uniprot id: W8PKP4
names: Similarity
messages: Belongs to the SfsA family.

195522:BD01 RS06460
gene id: 195522:BD01_RS06460
uniprot id: W8NUV8
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

195522:BD01 RS00790
gene id: 195522:BD01_RS00790
uniprot id: W8PI64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

195522:BD01 RS09350
gene id: 195522:BD01_RS09350
uniprot id: W8P7J3
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

195522:BD01 RS06695
gene id: 195522:BD01_RS06695
uniprot id: W8P2I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

195522:BD01 RS09085
gene id: 195522:BD01_RS09085
uniprot id: W8NWB0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

195522:BD01 RS01030
gene id: 195522:BD01_RS01030
uniprot id: W8P351
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

195522:BD01 RS05415
gene id: 195522:BD01_RS05415
uniprot id: W8NUF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

195522:BD01 RS00655
gene id: 195522:BD01_RS00655
uniprot id: W8NRQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

195522:BD01 RS00950
gene id: 195522:BD01_RS00950
uniprot id: W8NZF5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

195522:BD01 RS05910
gene id: 195522:BD01_RS05910
uniprot id: W8NUA4
names: Similarity
messages: Belongs to the threonine synthase family.

195522:BD01 RS05120
gene id: 195522:BD01_RS05120
uniprot id: W8P5E7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

195522:BD01 RS06920
gene id: 195522:BD01_RS06920
uniprot id: W8P2M6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

195522:BD01 RS10580
gene id: 195522:BD01_RS10580
uniprot id: W8PP41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

195522:BD01 RS03650
gene id: 195522:BD01_RS03650
uniprot id: W8P4J5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

195522:BD01 RS04850
gene id: 195522:BD01_RS04850
uniprot id: W8NU01
names: Similarity
messages: Belongs to the band 7/mec-2 family.

195522:BD01 RS07915
gene id: 195522:BD01_RS07915
uniprot id: W8P3B1
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

195522:BD01 RS10670
gene id: 195522:BD01_RS10670
uniprot id: W8P4R7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

195522:BD01 RS00665
gene id: 195522:BD01_RS00665
uniprot id: W8PI44
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS00160
gene id: 195522:BD01_RS00160
uniprot id: W8NRB0
names: Similarity
messages: Belongs to the UPF0292 family.

195522:BD01 RS02275
gene id: 195522:BD01_RS02275
uniprot id: W8P038
names: Similarity
messages: Belongs to the RutC family.

195522:BD01 RS05705
gene id: 195522:BD01_RS05705
uniprot id: W8NU76
names: Similarity
messages: Belongs to the UPF0310 family.

195522:BD01 RS06000
gene id: 195522:BD01_RS06000
uniprot id: W8NUN6
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

195522:BD01 RS02575
gene id: 195522:BD01_RS02575
uniprot id: W8NSR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

195522:BD01 RS06215
gene id: 195522:BD01_RS06215
uniprot id: W8P2A5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

195522:BD01 RS00885
gene id: 195522:BD01_RS00885
uniprot id: W8NRH6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

195522:BD01 RS03340
gene id: 195522:BD01_RS03340
uniprot id: W8NSW1
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS05060
gene id: 195522:BD01_RS05060
uniprot id: W8P5D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

195522:BD01 RS01750
gene id: 195522:BD01_RS01750
uniprot id: W8NZT6
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS08570
gene id: 195522:BD01_RS08570
uniprot id: W8P760
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

195522:BD01 RS04730
gene id: 195522:BD01_RS04730
uniprot id: W8PKJ2
names: Similarity
messages: Belongs to the HypE family.

195522:BD01 RS00565
gene id: 195522:BD01_RS00565
uniprot id: W8NRD2
names: Similarity
messages: Belongs to the HupF/HypC family.

195522:BD01 RS00750
gene id: 195522:BD01_RS00750
uniprot id: W8NZC5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

195522:BD01 RS04090
gene id: 195522:BD01_RS04090
uniprot id: W8NTM0
names: Similarity
messages: Belongs to the PDCD5 family.

195522:BD01 RS07805
gene id: 195522:BD01_RS07805
uniprot id: W8PMG6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS03785
gene id: 195522:BD01_RS03785
uniprot id: W8P102
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

195522:BD01 RS01020
gene id: 195522:BD01_RS01020
uniprot id: W8NRJ5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

195522:BD01 RS10455
gene id: 195522:BD01_RS10455
uniprot id: W8P898
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

195522:BD01 RS05940
gene id: 195522:BD01_RS05940
uniprot id: W8PLD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

195522:BD01 RS07485
gene id: 195522:BD01_RS07485
uniprot id: W8NV55
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

195522:BD01 RS07510
gene id: 195522:BD01_RS07510
uniprot id: W8P2Z8
names: Similarity
messages: Belongs to the UPF0147 family.

195522:BD01 RS11025
gene id: 195522:BD01_RS11025
uniprot id: W8P8H8
names: Similarity
messages: Belongs to the HerA family.

195522:BD01 RS10205
gene id: 195522:BD01_RS10205
uniprot id: W8NX12
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS10510
gene id: 195522:BD01_RS10510
uniprot id: W8P4N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

195522:BD01 RS09065
gene id: 195522:BD01_RS09065
uniprot id: W8NW21
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS07535
gene id: 195522:BD01_RS07535
uniprot id: W8P6L8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

195522:BD01 RS03665
gene id: 195522:BD01_RS03665
uniprot id: W8NT09
names: Similarity
messages: Belongs to the HypE family.

195522:BD01 RS00175
gene id: 195522:BD01_RS00175
uniprot id: W8P2M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

195522:BD01 RS05985
gene id: 195522:BD01_RS05985
uniprot id: W8PLE1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS06675
gene id: 195522:BD01_RS06675
uniprot id: W8NUZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

195522:BD01 RS10335
gene id: 195522:BD01_RS10335
uniprot id: W8NX33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

195522:BD01 RS01300
gene id: 195522:BD01_RS01300
uniprot id: W8NZL0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

195522:BD01 RS01885
gene id: 195522:BD01_RS01885
uniprot id: W8NRZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

195522:BD01 RS09265
gene id: 195522:BD01_RS09265
uniprot id: W8NW57
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

195522:BD01 RS07845
gene id: 195522:BD01_RS07845
uniprot id: W8NVQ1
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

195522:BD01 RS02375
gene id: 195522:BD01_RS02375
uniprot id: W8NS98
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS09100
gene id: 195522:BD01_RS09100
uniprot id: W8P7D8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

195522:BD01 RS09960
gene id: 195522:BD01_RS09960
uniprot id: W8NWR9
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

195522:BD01 RS08375
gene id: 195522:BD01_RS08375
uniprot id: W8PMS9
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

195522:BD01 RS07465
gene id: 195522:BD01_RS07465
uniprot id: W8PM66
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

195522:BD01 RS00155
gene id: 195522:BD01_RS00155
uniprot id: W8NYZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

195522:BD01 RS05460
gene id: 195522:BD01_RS05460
uniprot id: W8NU37
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS07260
gene id: 195522:BD01_RS07260
uniprot id: W8P2T6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

195522:BD01 RS04055
gene id: 195522:BD01_RS04055
uniprot id: W8P4T0
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

195522:BD01 RS03210
gene id: 195522:BD01_RS03210
uniprot id: W8NT58
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

195522:BD01 RS10910
gene id: 195522:BD01_RS10910
uniprot id: W8P8G2
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS01240
gene id: 195522:BD01_RS01240
uniprot id: W8NRN4
names: Similarity
messages: Belongs to the AOR/FOR family.

195522:BD01 RS02960
gene id: 195522:BD01_RS02960
uniprot id: W8PJI8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

195522:BD01 RS00275
gene id: 195522:BD01_RS00275
uniprot id: W8P2Q2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

195522:BD01 RS10900
gene id: 195522:BD01_RS10900
uniprot id: W8NXC7
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

195522:BD01 RS06395
gene id: 195522:BD01_RS06395
uniprot id: W8PLK9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

195522:BD01 RS08150
gene id: 195522:BD01_RS08150
uniprot id: W8P3F3
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS10350
gene id: 195522:BD01_RS10350
uniprot id: W8P881
names: Similarity
messages: Belongs to the DtxR/MntR family.

195522:BD01 RS05450
gene id: 195522:BD01_RS05450
uniprot id: W8P1Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

195522:BD01 RS09465
gene id: 195522:BD01_RS09465
uniprot id: W8NWI1
names: Similarity
messages: Belongs to the carbamate kinase family.

195522:BD01 RS00345
gene id: 195522:BD01_RS00345
uniprot id: W8PHX1
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

195522:BD01 RS05390
gene id: 195522:BD01_RS05390
uniprot id: W8NUE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

195522:BD01 RS08470
gene id: 195522:BD01_RS08470
uniprot id: W8PMU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

195522:BD01 RS07825
gene id: 195522:BD01_RS07825
uniprot id: W8NVE9
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

195522:BD01 RS00595
gene id: 195522:BD01_RS00595
uniprot id: W8PI30
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS09095
gene id: 195522:BD01_RS09095
uniprot id: W8PN72
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

195522:BD01 RS10575
gene id: 195522:BD01_RS10575
uniprot id: W8NWW5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

195522:BD01 RS09575
gene id: 195522:BD01_RS09575
uniprot id: W8NWA9
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

195522:BD01 RS01015
gene id: 195522:BD01_RS01015
uniprot id: W8NRW7
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

195522:BD01 RS08575
gene id: 195522:BD01_RS08575
uniprot id: W8P3M8
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS02460
gene id: 195522:BD01_RS02460
uniprot id: W8P079
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the N-terminal section; belongs to the DHBP synthase family.

195522:BD01 RS05495
gene id: 195522:BD01_RS05495
uniprot id: W8P5L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

195522:BD01 RS01205
gene id: 195522:BD01_RS01205
uniprot id: W8NZJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

195522:BD01 RS00420
gene id: 195522:BD01_RS00420
uniprot id: W8PHZ9
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

195522:BD01 RS10740
gene id: 195522:BD01_RS10740
uniprot id: W8PP67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

195522:BD01 RS06145
gene id: 195522:BD01_RS06145
uniprot id: W8NUE3
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS04845
gene id: 195522:BD01_RS04845
uniprot id: W8P1I9
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

195522:BD01 RS06070
gene id: 195522:BD01_RS06070
uniprot id: W8NUC8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS04280
gene id: 195522:BD01_RS04280
uniprot id: W8NTQ8
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

195522:BD01 RS08335
gene id: 195522:BD01_RS08335
uniprot id: W8P3I6
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

195522:BD01 RS06760
gene id: 195522:BD01_RS06760
uniprot id: W8PLT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

195522:BD01 RS06440
gene id: 195522:BD01_RS06440
uniprot id: W8NUJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

195522:BD01 RS01060
gene id: 195522:BD01_RS01060
uniprot id: W8NRX4
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

195522:BD01 RS02145
gene id: 195522:BD01_RS02145
uniprot id: W8PIX3
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

195522:BD01 RS08970
gene id: 195522:BD01_RS08970
uniprot id: W8NW02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

195522:BD01 RS09480
gene id: 195522:BD01_RS09480
uniprot id: W8P7M3
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

195522:BD01 RS04675
gene id: 195522:BD01_RS04675
uniprot id: W8NTK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

195522:BD01 RS07830
gene id: 195522:BD01_RS07830
uniprot id: W8PMH1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

195522:BD01 RS01210
gene id: 195522:BD01_RS01210
uniprot id: W8NS00
names: Similarity
messages: Belongs to the UPF0440 family.

195522:BD01 RS11070
gene id: 195522:BD01_RS11070
uniprot id: W8NUQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

195522:BD01 RS06170
gene id: 195522:BD01_RS06170
uniprot id: W8NUE6
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

195522:BD01 RS00215
gene id: 195522:BD01_RS00215
uniprot id: W8NR40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

195522:BD01 RS10885
gene id: 195522:BD01_RS10885
uniprot id: W8PP94
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

195522:BD01 RS02195
gene id: 195522:BD01_RS02195
uniprot id: W8P3T2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS04755
gene id: 195522:BD01_RS04755
uniprot id: W8PKJ5
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS01305
gene id: 195522:BD01_RS01305
uniprot id: W8NS18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

195522:BD01 RS01935
gene id: 195522:BD01_RS01935
uniprot id: W8NS05
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

195522:BD01 RS09450
gene id: 195522:BD01_RS09450
uniprot id: W8PNC6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

195522:BD01 RS09730
gene id: 195522:BD01_RS09730
uniprot id: W8NWE0
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

195522:BD01 RS01620
gene id: 195522:BD01_RS01620
uniprot id: W8NZR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

195522:BD01 RS08775
gene id: 195522:BD01_RS08775
uniprot id: W8NW66
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

195522:BD01 RS05950
gene id: 195522:BD01_RS05950
uniprot id: W8NUM9
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

195522:BD01 RS09605
gene id: 195522:BD01_RS09605
uniprot id: W8PNF4
names: Similarity
messages: Belongs to the peptidase S8 family.

195522:BD01 RS00745
gene id: 195522:BD01_RS00745
uniprot id: W8P311
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

195522:BD01 RS03105
gene id: 195522:BD01_RS03105
uniprot id: W8PJL3
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

195522:BD01 RS10295
gene id: 195522:BD01_RS10295
uniprot id: W8PNZ1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

195522:BD01 RS06835
gene id: 195522:BD01_RS06835
uniprot id: W8PLU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

195522:BD01 RS04110
gene id: 195522:BD01_RS04110
uniprot id: W8P159
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS05965
gene id: 195522:BD01_RS05965
uniprot id: W8P5T1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

195522:BD01 RS02625
gene id: 195522:BD01_RS02625
uniprot id: W8NSS4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS10500
gene id: 195522:BD01_RS10500
uniprot id: W8PP26
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS02930
gene id: 195522:BD01_RS02930
uniprot id: W8NT03
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS09270
gene id: 195522:BD01_RS09270
uniprot id: W8PNA2
names: Similarity
messages: Belongs to the UPF0111 family.

195522:BD01 RS01905
gene id: 195522:BD01_RS01905
uniprot id: W8NSD6
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

195522:BD01 RS10700
gene id: 195522:BD01_RS10700
uniprot id: W8NWY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

195522:BD01 RS00920
gene id: 195522:BD01_RS00920
uniprot id: W8P339
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

195522:BD01 RS08065
gene id: 195522:BD01_RS08065
uniprot id: W8PML6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

195522:BD01 RS03430
gene id: 195522:BD01_RS03430
uniprot id: W8P0U5
names: Similarity
messages: Belongs to the peptidase S9C family.

195522:BD01 RS07165
gene id: 195522:BD01_RS07165
uniprot id: W8P6E6
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS01775
gene id: 195522:BD01_RS01775
uniprot id: W8NZU1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS08830
gene id: 195522:BD01_RS08830
uniprot id: W8NVX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

195522:BD01 RS04125
gene id: 195522:BD01_RS04125
uniprot id: W8PK67
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

195522:BD01 RS08630
gene id: 195522:BD01_RS08630
uniprot id: W8NW42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

195522:BD01 RS04370
gene id: 195522:BD01_RS04370
uniprot id: W8P1A2
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

195522:BD01 RS07355
gene id: 195522:BD01_RS07355
uniprot id: W8P2V8
names: Similarity
messages: Belongs to the peptidase C56 family.

195522:BD01 RS06300
gene id: 195522:BD01_RS06300
uniprot id: W8P5X9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

195522:BD01 RS00435
gene id: 195522:BD01_RS00435
uniprot id: W8NRL3
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS03195
gene id: 195522:BD01_RS03195
uniprot id: W8PJN0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

195522:BD01 RS01570
gene id: 195522:BD01_RS01570
uniprot id: W8NZQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

195522:BD01 RS00915
gene id: 195522:BD01_RS00915
uniprot id: W8PI82
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

195522:BD01 RS08180
gene id: 195522:BD01_RS08180
uniprot id: W8NVK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

195522:BD01 RS00195
gene id: 195522:BD01_RS00195
uniprot id: W8PHS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

195522:BD01 RS01280
gene id: 195522:BD01_RS01280
uniprot id: W8NS13
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS06435
gene id: 195522:BD01_RS06435
uniprot id: W8NUV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

195522:BD01 RS10505
gene id: 195522:BD01_RS10505
uniprot id: W8P8A5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

195522:BD01 RS07720
gene id: 195522:BD01_RS07720
uniprot id: W8NVN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

195522:BD01 RS08735
gene id: 195522:BD01_RS08735
uniprot id: W8PN03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

195522:BD01 RS01840
gene id: 195522:BD01_RS01840
uniprot id: W8PIQ9
names: Similarity
messages: Belongs to the glutaredoxin family.

195522:BD01 RS05960
gene id: 195522:BD01_RS05960
uniprot id: W8PLD7
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

195522:BD01 RS02250
gene id: 195522:BD01_RS02250
uniprot id: W8P032
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

195522:BD01 RS01715
gene id: 195522:BD01_RS01715
uniprot id: W8PIN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Membrane

195522:BD01 RS00900
gene id: 195522:BD01_RS00900
uniprot id: W8NZE8
names: Similarity
messages: Belongs to the glutaredoxin family.

195522:BD01 RS00905
gene id: 195522:BD01_RS00905
uniprot id: W8NRU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

195522:BD01 RS04085
gene id: 195522:BD01_RS04085
uniprot id: W8P155
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

195522:BD01 RS07430
gene id: 195522:BD01_RS07430
uniprot id: W8NVD9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS00725
gene id: 195522:BD01_RS00725
uniprot id: W8NZC1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal-type GPI family.
messages: Cytoplasm
messages: Homodimer.

195522:BD01 RS05870
gene id: 195522:BD01_RS05870
uniprot id: W8P5R8
names: Similarity
messages: Belongs to the UPF0047 family.

195522:BD01 RS00220
gene id: 195522:BD01_RS00220
uniprot id: W8PHS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

195522:BD01 RS04470
gene id: 195522:BD01_RS04470
uniprot id: W8NTF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

195522:BD01 RS07255
gene id: 195522:BD01_RS07255
uniprot id: W8P6G1
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

195522:BD01 RS02485
gene id: 195522:BD01_RS02485
uniprot id: W8P085
names: Similarity
messages: Belongs to the SAICAR synthetase family.

195522:BD01 RS10490
gene id: 195522:BD01_RS10490
uniprot id: W8NX59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

195522:BD01 RS02805
gene id: 195522:BD01_RS02805
uniprot id: W8NSK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

195522:BD01 RS08860
gene id: 195522:BD01_RS08860
uniprot id: W8PN28
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

195522:BD01 RS01275
gene id: 195522:BD01_RS01275
uniprot id: W8NZK6
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

195522:BD01 RS04995
gene id: 195522:BD01_RS04995
uniprot id: W8P1M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

195522:BD01 RS07150
gene id: 195522:BD01_RS07150
uniprot id: W8NV87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

195522:BD01 RS05505
gene id: 195522:BD01_RS05505
uniprot id: W8NUG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

195522:BD01 RS00135
gene id: 195522:BD01_RS00135
uniprot id: W8NRA3
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

195522:BD01 RS05590
gene id: 195522:BD01_RS05590
uniprot id: W8PL70
names: Subcellular Location Annotation
messages: Membrane

195522:BD01 RS01680
gene id: 195522:BD01_RS01680
uniprot id: W8NRW6
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

195522:BD01 RS10120
gene id: 195522:BD01_RS10120
uniprot id: W8PNS0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

195522:BD01 RS07730
gene id: 195522:BD01_RS07730
uniprot id: W8PMF2
names: Subunit
messages: Homodimer.

195522:BD01 RS04770
gene id: 195522:BD01_RS04770
uniprot id: W8P1H3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.