187420:MTH RS01240
gene id: 187420:MTH_RS01240
uniprot id: O26369
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

187420:MTH RS00630
gene id: 187420:MTH_RS00630
uniprot id: O26244
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

187420:MTH RS03685
gene id: 187420:MTH_RS03685
uniprot id: O26878
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively (By similarity).
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity (By similarity).

187420:MTH RS07050
gene id: 187420:MTH_RS07050
uniprot id: O27520
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

187420:MTH RS01410
gene id: 187420:MTH_RS01410
uniprot id: O26407
names: Similarity
messages: Belongs to the HerA family.

187420:MTH RS06190
gene id: 187420:MTH_RS06190
uniprot id: P19499
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FrhB family.
messages: Heterocomplex of the form (alpha(1)beta(1)gamma(1))(8).
messages: Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen.
messages: There are 12-13 Fe atoms per alpha/beta/gamma unit of the FRH.

187420:MTH RS05690
gene id: 187420:MTH_RS05690
uniprot id: O27264
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

187420:MTH RS05255
gene id: 187420:MTH_RS05255
uniprot id: O27179
names: Activity Regulation
names: Function
names: Subunit
messages: Heterooctamer of four A and four B subunits.
messages: Inhibited by ADP and alpha-ketoglutarate.
messages: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

187420:MTH RS06300
gene id: 187420:MTH_RS06300
uniprot id: O27375
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

187420:MTH RS03385
gene id: 187420:MTH_RS03385
uniprot id: O26818
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

187420:MTH RS09005
gene id: 187420:MTH_RS09005
uniprot id: O27907
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrB family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC. It forms a complex with the F420-non-reducing hydrogenase (Mvh), which provides the reducing equivalents to the heterodisulfide reductase.

187420:MTH RS04505
gene id: 187420:MTH_RS04505
uniprot id: O27034
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

187420:MTH RS05540
gene id: 187420:MTH_RS05540
uniprot id: O27233
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Cytoplasm
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.
messages: There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I.

187420:MTH RS03905
gene id: 187420:MTH_RS03905
uniprot id: O26917
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Component of a hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. These reactions are part of the biosynthesis pathway of coenzyme B.
messages: Functional assignment as methanogen HACN has been made based on the presence of the YLRT motif involved in substrate specificity as discussed in PubMed:20170198.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.

187420:MTH RS01230
gene id: 187420:MTH_RS01230
uniprot id: O26367
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

187420:MTH RS03305
gene id: 187420:MTH_RS03305
uniprot id: O26802
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

187420:MTH RS07040
gene id: 187420:MTH_RS07040
uniprot id: O27518
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

187420:MTH RS08680
gene id: 187420:MTH_RS08680
uniprot id: O27840
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

187420:MTH RS04840
gene id: 187420:MTH_RS04840
uniprot id: O27102
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

187420:MTH RS03325
gene id: 187420:MTH_RS03325
uniprot id: O26806
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

187420:MTH RS08890
gene id: 187420:MTH_RS08890
uniprot id: O27884
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

187420:MTH RS01095
gene id: 187420:MTH_RS01095
uniprot id: O26342
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heterohexamer composed of four small subunits (RfcS) and two large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA. In conjunction with PCNA stimulates DNA synthesis by PolB, relieving inhibition by replication protein A (RPA).

187420:MTH RS03775
gene id: 187420:MTH_RS03775
uniprot id: O26894
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

187420:MTH RS05280
gene id: 187420:MTH_RS05280
uniprot id: O27184
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

187420:MTH RS05600
gene id: 187420:MTH_RS05600
uniprot id: O27246
names: Similarity
messages: Belongs to the UPF0251 family.

187420:MTH RS05875
gene id: 187420:MTH_RS05875
uniprot id: O27300
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

187420:MTH RS00705
gene id: 187420:MTH_RS00705
uniprot id: O26259
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

187420:MTH RS08175
gene id: 187420:MTH_RS08175
uniprot id: O27741
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.jannaschii MJ1570.

187420:MTH RS05345
gene id: 187420:MTH_RS05345
uniprot id: O27198
names: Similarity
messages: Belongs to the TmcAL family.

187420:MTH RS02560
gene id: 187420:MTH_RS02560
uniprot id: O26650
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

187420:MTH RS02690
gene id: 187420:MTH_RS02690
uniprot id: O26680
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

187420:MTH RS07485
gene id: 187420:MTH_RS07485
uniprot id: O27606
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

187420:MTH RS03675
gene id: 187420:MTH_RS03675
uniprot id: O26876
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

187420:MTH RS00575
gene id: 187420:MTH_RS00575
uniprot id: O26233
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

187420:MTH RS06685
gene id: 187420:MTH_RS06685
uniprot id: O27448
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis (PubMed:12686546). Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation (Potential). Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin (Potential).
messages: Homotetramer; dimer of dimers.

187420:MTH RS07725
gene id: 187420:MTH_RS07725
uniprot id: O27650
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

187420:MTH RS00910
gene id: 187420:MTH_RS00910
uniprot id: O26302
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS00240
gene id: 187420:MTH_RS00240
uniprot id: O26154
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

187420:MTH RS03175
gene id: 187420:MTH_RS03175
uniprot id: O26776
names: Function
messages: Probably involved in the biogenesis of the ribosome.

187420:MTH RS01860
gene id: 187420:MTH_RS01860
uniprot id: O26503
names: Similarity
messages: Belongs to the FTR family.

187420:MTH RS00100
gene id: 187420:MTH_RS00100
uniprot id: O26128
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

187420:MTH RS03800
gene id: 187420:MTH_RS03800
uniprot id: O26899
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

187420:MTH RS07750
gene id: 187420:MTH_RS07750
uniprot id: O27655
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Constitutively expressed (at protein level).
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

187420:MTH RS00190
gene id: 187420:MTH_RS00190
uniprot id: O26145
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

187420:MTH RS05645
gene id: 187420:MTH_RS05645
uniprot id: O27255
names: Similarity
names: Subunit
messages: Belongs to the UPF0045 family.
messages: Homotetramer.

187420:MTH RS08910
gene id: 187420:MTH_RS08910
uniprot id: O27888
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

187420:MTH RS04135
gene id: 187420:MTH_RS04135
uniprot id: O26962
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

187420:MTH RS08860
gene id: 187420:MTH_RS08860
uniprot id: O27877
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

187420:MTH RS05060
gene id: 187420:MTH_RS05060
uniprot id: O27139
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

187420:MTH RS04765
gene id: 187420:MTH_RS04765
uniprot id: O27089
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

187420:MTH RS02720
gene id: 187420:MTH_RS02720
uniprot id: O26687
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

187420:MTH RS03815
gene id: 187420:MTH_RS03815
uniprot id: O26902
names: Similarity
messages: Belongs to the UPF0305 family.

187420:MTH RS07585
gene id: 187420:MTH_RS07585
uniprot id: Q50563
names: Similarity
messages: Belongs to the phosphohexose mutase family.

187420:MTH RS05090
gene id: 187420:MTH_RS05090
uniprot id: O27145
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS04210
gene id: 187420:MTH_RS04210
uniprot id: O26978
names: Caution
names: Similarity
messages: Belongs to the peptidase S16 family.
messages: Lacks the conserved Ser-Lys catalytic dyad essential for proteolytic activity. Its enzyme activity is therefore unsure.

187420:MTH RS09850
gene id: 187420:MTH_RS09850
uniprot id: O27316
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

187420:MTH RS06155
gene id: 187420:MTH_RS06155
uniprot id: O27350
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

187420:MTH RS00170
gene id: 187420:MTH_RS00170
uniprot id: O26141
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

187420:MTH RS05340
gene id: 187420:MTH_RS05340
uniprot id: O27197
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FKBP-type PPIase family.
messages: Catalyzes the cis-trans isomerization of peptidyl prolyl bonds and accelerates protein folding. Also exhibits chaperone-like activity (PubMed:10824098). In vitro, can use oligopeptides such as N-succinyl-Ala-Leu-Pro-Phe-p-nitroanilide and N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrates. The PPIase activity is much lower than those of other FKBPs reported against oligopeptidyl substrates. As a chaperone, protects green fluorescent protein (GFP) and rhodanese from thermal denaturation or aggregation, and suppresses the aggregation of chemically unfolded rhodanese and elevates the yield of its refolding (PubMed:10824098).
messages: Contains an N-terminal PPIase domain, an IF (Insert in the Flap) domain and a C-terminal domain (CTD). Aggregation suppressing activity against chemically unfolded protein is exerted mainly by the CTD while N- and C-terminal domains contribute to thermal protein aggregation suppression. The CTD probably contributes to hexamerization.
messages: Homohexamer.

187420:MTH RS00885
gene id: 187420:MTH_RS00885
uniprot id: O26296
names: Similarity
messages: Belongs to the glutamate synthase family.

187420:MTH RS01110
gene id: 187420:MTH_RS01110
uniprot id: O26345
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

187420:MTH RS00765
gene id: 187420:MTH_RS00765
uniprot id: O26270
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

187420:MTH RS07490
gene id: 187420:MTH_RS07490
uniprot id: O27607
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

187420:MTH RS03920
gene id: 187420:MTH_RS03920
uniprot id: O26920
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

187420:MTH RS07925
gene id: 187420:MTH_RS07925
uniprot id: O27692
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Feedback inhibited by tryptophan.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).

187420:MTH RS02195
gene id: 187420:MTH_RS02195
uniprot id: O26572
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

187420:MTH RS07940
gene id: 187420:MTH_RS07940
uniprot id: O27695
names: Similarity
messages: Belongs to the TrpF family.

187420:MTH RS00120
gene id: 187420:MTH_RS00120
uniprot id: O26132
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

187420:MTH RS00775
gene id: 187420:MTH_RS00775
uniprot id: O26272
names: Similarity
messages: Belongs to the SAICAR synthetase family.

187420:MTH RS02200
gene id: 187420:MTH_RS02200
uniprot id: O26573
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS09025
gene id: 187420:MTH_RS09025
uniprot id: O27911
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

187420:MTH RS08470
gene id: 187420:MTH_RS08470
uniprot id: O27793
names: Similarity
messages: Belongs to the thymidylate kinase family.

187420:MTH RS01150
gene id: 187420:MTH_RS01150
uniprot id: O26352
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

187420:MTH RS01070
gene id: 187420:MTH_RS01070
uniprot id: O26337
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.
messages: Homodimer.

187420:MTH RS04530
gene id: 187420:MTH_RS04530
uniprot id: O27039
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

187420:MTH RS05570
gene id: 187420:MTH_RS05570
uniprot id: O27240
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS08075
gene id: 187420:MTH_RS08075
uniprot id: O27721
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

187420:MTH RS08335
gene id: 187420:MTH_RS08335
uniprot id: P56810
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

187420:MTH RS05900
gene id: 187420:MTH_RS05900
uniprot id: O27305
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS08310
gene id: 187420:MTH_RS08310
uniprot id: O27767
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

187420:MTH RS07095
gene id: 187420:MTH_RS07095
uniprot id: O27530
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS07720
gene id: 187420:MTH_RS07720
uniprot id: O27649
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

187420:MTH RS08290
gene id: 187420:MTH_RS08290
uniprot id: O27763
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

187420:MTH RS03445
gene id: 187420:MTH_RS03445
uniprot id: O26830
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Cell membrane

187420:MTH RS07410
gene id: 187420:MTH_RS07410
uniprot id: O27592
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

187420:MTH RS05445
gene id: 187420:MTH_RS05445
uniprot id: O27214
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Homohexamer.

187420:MTH RS05515
gene id: 187420:MTH_RS05515
uniprot id: O27228
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

187420:MTH RS06115
gene id: 187420:MTH_RS06115
uniprot id: O27342
names: Similarity
messages: Belongs to the UPF0248 family.

187420:MTH RS02540
gene id: 187420:MTH_RS02540
uniprot id: O26646
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS06760
gene id: 187420:MTH_RS06760
uniprot id: O27464
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

187420:MTH RS08870
gene id: 187420:MTH_RS08870
uniprot id: O27880
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

187420:MTH RS05520
gene id: 187420:MTH_RS05520
uniprot id: O27229
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

187420:MTH RS08040
gene id: 187420:MTH_RS08040
uniprot id: O27715
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

187420:MTH RS03985
gene id: 187420:MTH_RS03985
uniprot id: O26934
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

187420:MTH RS04620
gene id: 187420:MTH_RS04620
uniprot id: O27057
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

187420:MTH RS07740
gene id: 187420:MTH_RS07740
uniprot id: O27653
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

187420:MTH RS06270
gene id: 187420:MTH_RS06270
uniprot id: O27369
names: Caution
names: Function
names: Similarity
messages: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Induces RNA cleavage activity in the RNA polymerase. In its presence, the cleavage activity of the RNA polymerase truncates the RNA back to position +15 in a stepwise manner by releasing mainly dinucleotides from the 3'-end of the nascent RNA. The truncated RNAs are able to continue elongation. Involved in transcriptional proofreading and fidelity. Misincorporation of nucleotides during elongation of transcription leads to arrested elongation complexes which are rescued by TFS-promoted removal of a dinucleotide from the 3'-end. TFS is able to induce a cleavage resynthesis cycle in stalled elongation complexes (resulting from the next missing nucleotide or a reduced incorporation rate of a wrong nucleotide) preventing misincorporation and enabling proofreading in a post-incorporation manner. Pausing of elongation complexes is the main determinant of TFS-induced RNA cleavage.
messages: More similar by sequence similarity to the eukaryotic RNA polymerase subunits.

187420:MTH RS05080
gene id: 187420:MTH_RS05080
uniprot id: O27143
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

187420:MTH RS03200
gene id: 187420:MTH_RS03200
uniprot id: O26781
names: Similarity
messages: Belongs to the SDO1/SBDS family.

187420:MTH RS05505
gene id: 187420:MTH_RS05505
uniprot id: O27226
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

187420:MTH RS05430
gene id: 187420:MTH_RS05430
uniprot id: O27212
names: Cofactor
names: Similarity
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

187420:MTH RS07270
gene id: 187420:MTH_RS07270
uniprot id: O27566
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Homodimer or monomer. The Ni-sirohydrochlorin a,c-diamide reductive cyclase complex is composed of a NifH homolog component CfbC and a NifD homolog component CfbD.
messages: Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes both the six-electron reduction of the tetrahydroporphyrin ring system and the gamma-lactamization of the c-acetamide side chain of Ni-sirohydrochlorin a,c-diamide to yield 15,17(3)-seco-F430-17(3)-acid (seco-F430), the last intermediate in the biosynthesis of the coenzyme F430.

187420:MTH RS05325
gene id: 187420:MTH_RS05325
uniprot id: O27194
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.

187420:MTH RS03170
gene id: 187420:MTH_RS03170
uniprot id: O26775
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

187420:MTH RS01685
gene id: 187420:MTH_RS01685
uniprot id: O26467
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS04930
gene id: 187420:MTH_RS04930
uniprot id: O27120
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

187420:MTH RS07665
gene id: 187420:MTH_RS07665
uniprot id: O27637
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

187420:MTH RS00050
gene id: 187420:MTH_RS00050
uniprot id: O26118
names: Similarity
messages: Belongs to the SUI1 family.

187420:MTH RS02515
gene id: 187420:MTH_RS02515
uniprot id: O26641
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

187420:MTH RS06665
gene id: 187420:MTH_RS06665
uniprot id: P41654
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

187420:MTH RS07350
gene id: 187420:MTH_RS07350
uniprot id: O27580
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site (By similarity).

187420:MTH RS03630
gene id: 187420:MTH_RS03630
uniprot id: O26868
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

187420:MTH RS05745
gene id: 187420:MTH_RS05745
uniprot id: O27275
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Heterododecamer composed of 6 subunits alpha and 6 subunits beta.
messages: Involved in the biosynthesis of the coenzyme M (2-mercaptoethanesulfonic acid). Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde.

187420:MTH RS06575
gene id: 187420:MTH_RS06575
uniprot id: O27428
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

187420:MTH RS00250
gene id: 187420:MTH_RS00250
uniprot id: O26156
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FPP/GGPP synthase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

187420:MTH RS09895
gene id: 187420:MTH_RS09895
uniprot id: P56815
names: Caution
names: Cofactor
names: Subunit
messages: Binds 2 [4Fe-4S] clusters.
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.
messages: There seems to be a sequencing error that fuses together porC and porD. We have cut the ORF into its two constituents.

187420:MTH RS01690
gene id: 187420:MTH_RS01690
uniprot id: O26468
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

187420:MTH RS04515
gene id: 187420:MTH_RS04515
uniprot id: O27036
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit (By similarity).

187420:MTH RS07625
gene id: 187420:MTH_RS07625
uniprot id: O27629
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

187420:MTH RS05930
gene id: 187420:MTH_RS05930
uniprot id: O27311
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

187420:MTH RS06670
gene id: 187420:MTH_RS06670
uniprot id: P41655
names: Similarity
messages: Belongs to the UbiD family.

187420:MTH RS06205
gene id: 187420:MTH_RS06205
uniprot id: P19496
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Heterocomplex of the form (alpha(1)beta(1)gamma(1))(8).
messages: Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen.
messages: There are 12-13 Fe atoms/(alpha(1)beta(1)gamma(1)) unit of the FRH.

187420:MTH RS00770
gene id: 187420:MTH_RS00770
uniprot id: O26271
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Homodimer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits (By similarity).
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

187420:MTH RS03460
gene id: 187420:MTH_RS03460
uniprot id: O26833
names: Similarity
messages: To M.jannaschii MJ1452.

187420:MTH RS04270
gene id: 187420:MTH_RS04270
uniprot id: P12769
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DNA photolyase class-2 family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 coenzyme F420 non-covalently per subunit.
messages: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.

187420:MTH RS03480
gene id: 187420:MTH_RS03480
uniprot id: O26837
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

187420:MTH RS02895
gene id: 187420:MTH_RS02895
uniprot id: O26719
names: Domain
messages: Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains the catalytic cysteine residue (By similarity).

187420:MTH RS06200
gene id: 187420:MTH_RS06200
uniprot id: P19497
names: Miscellaneous
names: Similarity
messages: Belongs to the peptidase A31 family.
messages: Does not copurify with the active FRH.

187420:MTH RS02830
gene id: 187420:MTH_RS02830
uniprot id: P72011
names: Similarity
messages: Belongs to the UPF0179 family.

187420:MTH RS07415
gene id: 187420:MTH_RS07415
uniprot id: O27593
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

187420:MTH RS07400
gene id: 187420:MTH_RS07400
uniprot id: O27590
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

187420:MTH RS06580
gene id: 187420:MTH_RS06580
uniprot id: O27429
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

187420:MTH RS03755
gene id: 187420:MTH_RS03755
uniprot id: O26890
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.

187420:MTH RS05425
gene id: 187420:MTH_RS05425
uniprot id: O27211
names: Function
names: Similarity
messages: Belongs to the HMD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

187420:MTH RS09675
gene id: 187420:MTH_RS09675
uniprot id: O27230
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

187420:MTH RS08505
gene id: 187420:MTH_RS08505
uniprot id: O27801
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

187420:MTH RS06450
gene id: 187420:MTH_RS06450
uniprot id: O27404
names: Caution
names: Cofactor
names: Function
names: Induction
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Binds 2 iron ions per subunit.
messages: By iron limitation.
messages: Catalyzes the oxidation of F420H(2) with O(2) (By similarity). May be involved in O(2) detoxification, reducing the intracellular O(2) concentration to a level allowing growth at the expense of methane formation (By similarity).
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.
messages: Was originally thought to be a subunit of methylviologen hydrolase II.

187420:MTH RS00070
gene id: 187420:MTH_RS00070
uniprot id: O26122
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

187420:MTH RS01170
gene id: 187420:MTH_RS01170
uniprot id: O26355
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

187420:MTH RS04525
gene id: 187420:MTH_RS04525
uniprot id: O27038
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

187420:MTH RS04450
gene id: 187420:MTH_RS04450
uniprot id: O27024
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

187420:MTH RS03390
gene id: 187420:MTH_RS03390
uniprot id: O26819
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

187420:MTH RS01530
gene id: 187420:MTH_RS01530
uniprot id: O26434
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

187420:MTH RS05350
gene id: 187420:MTH_RS05350
uniprot id: O27199
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

187420:MTH RS04065
gene id: 187420:MTH_RS04065
uniprot id: O26950
names: Similarity
messages: To M.jannaschii MJ1183.

187420:MTH RS00020
gene id: 187420:MTH_RS00020
uniprot id: O26112
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

187420:MTH RS06005
gene id: 187420:MTH_RS06005
uniprot id: P21348
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

187420:MTH RS03595
gene id: 187420:MTH_RS03595
uniprot id: O26861
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

187420:MTH RS00155
gene id: 187420:MTH_RS00155
uniprot id: O26139
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

187420:MTH RS03810
gene id: 187420:MTH_RS03810
uniprot id: O26901
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. Helicase with 3'-to 5'- polarity; able to unwind over 100 bp of DNA at 50 degrees Celsius. Unwinds forked DNA, preferentially on lagging strand forks; has weaker activity on Holliday junctions. Displaces the invading strand in DNA D-loops. Unwinds short oligonucleotides from dsDNA with 3'- but not blunt ends or 5'-ssDNA tails in an ATP-dependent manner. ATPase activity is stimulated by ssDNA but not dsDNA, protein binds ssDNA, dsDNA with 5'- or 3'-overhangs but not blunt ended dsDNA and replication forks. Replication forks bind both this protein and RPA. RPA does not stimulate the helicase activity of this protein.
messages: Monomer (By similarity). Binds replication protein A (RPA), in presence and absence of DNA.
messages: The C-terminal region (about 633-690) acts as a brake for ATP hydrolysis (PubMed:17991488) and interacts with RPA (PubMed:21195035).

187420:MTH RS02995
gene id: 187420:MTH_RS02995
uniprot id: O26739
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg-94 inactivates the nitrogenase reductase and regulates nitrogenase activity.

187420:MTH RS09195
gene id: 187420:MTH_RS09195
uniprot id: O27937
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).
messages: Cytoplasm

187420:MTH RS00030
gene id: 187420:MTH_RS00030
uniprot id: O26114
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

187420:MTH RS08620
gene id: 187420:MTH_RS08620
uniprot id: O27825
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

187420:MTH RS06295
gene id: 187420:MTH_RS06295
uniprot id: O27374
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

187420:MTH RS06410
gene id: 187420:MTH_RS06410
uniprot id: O27397
names: Function
names: Similarity
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion (By similarity).

187420:MTH RS03465
gene id: 187420:MTH_RS03465
uniprot id: O26834
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

187420:MTH RS04735
gene id: 187420:MTH_RS04735
uniprot id: O27083
names: Function
names: Similarity
messages: Belongs to the precorrin-6x reductase family.
messages: Catalyzes the reduction of the macrocycle of cobalt-precorrin-6A to cobalt-precorrin-6B.

187420:MTH RS08585
gene id: 187420:MTH_RS08585
uniprot id: O27818
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

187420:MTH RS01525
gene id: 187420:MTH_RS01525
uniprot id: O26433
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

187420:MTH RS01195
gene id: 187420:MTH_RS01195
uniprot id: O26360
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

187420:MTH RS00105
gene id: 187420:MTH_RS00105
uniprot id: O26129
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

187420:MTH RS07260
gene id: 187420:MTH_RS07260
uniprot id: O27564
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Calcium-gated potassium channel.
messages: Cell membrane
messages: Homotetramer.
messages: Inhibited by charybdotoxin (CTX), a protein from scorpion venom.
messages: It is not known whether calcium is the physiological ligand.
messages: The channel is composed of 4 repeated units, each containing a transmembrane pore part and a gating ring part. The gating ring is composed of eight identical RCK (Regulators of K conductance) domains, in an alternating arrangement of one domain from each of the four subunits and four from the intracellular solution. Two protein interfaces between dimers of RCK domains from the pore-forming subunit and from the intracellular solution hold the ring together. One is called the fixed interface and the other the flexible interface. The flexible interface forms a cleft where calcium binds. Upon calcium binding the gating ring undergoes a conformational change that enables it to pull open the inner helices of the pore, allowing ion conduction.

187420:MTH RS01395
gene id: 187420:MTH_RS01395
uniprot id: O26404
names: Similarity
messages: Belongs to the HepT RNase toxin family.

187420:MTH RS00935
gene id: 187420:MTH_RS00935
uniprot id: O26309
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

187420:MTH RS07205
gene id: 187420:MTH_RS07205
uniprot id: O27553
names: Similarity
messages: Belongs to the CutA family.

187420:MTH RS00065
gene id: 187420:MTH_RS00065
uniprot id: O26121
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

187420:MTH RS05740
gene id: 187420:MTH_RS05740
uniprot id: O27274
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ComD family.
messages: Heterododecamer composed of 6 subunits alpha and 6 subunits beta.
messages: Involved in the biosynthesis of the coenzyme M (2-mercaptoethanesulfonic acid). Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde.

187420:MTH RS07630
gene id: 187420:MTH_RS07630
uniprot id: O27630
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

187420:MTH RS06860
gene id: 187420:MTH_RS06860
uniprot id: O27484
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

187420:MTH RS06305
gene id: 187420:MTH_RS06305
uniprot id: O27376
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

187420:MTH RS08590
gene id: 187420:MTH_RS08590
uniprot id: O27819
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

187420:MTH RS03250
gene id: 187420:MTH_RS03250
uniprot id: O26791
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS00860
gene id: 187420:MTH_RS00860
uniprot id: O26290
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

187420:MTH RS08635
gene id: 187420:MTH_RS08635
uniprot id: O27830
names: Similarity
messages: Belongs to the helicase family.

187420:MTH RS02010
gene id: 187420:MTH_RS02010
uniprot id: O26533
names: Similarity
messages: Belongs to the UPF0201 family.

187420:MTH RS06285
gene id: 187420:MTH_RS06285
uniprot id: O27372
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

187420:MTH RS03590
gene id: 187420:MTH_RS03590
uniprot id: O26860
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

187420:MTH RS04215
gene id: 187420:MTH_RS04215
uniprot id: O26979
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

187420:MTH RS06065
gene id: 187420:MTH_RS06065
uniprot id: O27336
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. Cleaves both mobile and immobile junctions. Converts a synthetic Hj to nicked duplex products. Binds a variety of branched DNA structures but linear dsDNA poorly; cleaves only 4-way junctions. Confers UV and mitomycin C resistance to E.coli cells lacking the endogenous Hj machinery RuvABC.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

187420:MTH RS07080
gene id: 187420:MTH_RS07080
uniprot id: O27527
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

187420:MTH RS08545
gene id: 187420:MTH_RS08545
uniprot id: O27809
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS01255
gene id: 187420:MTH_RS01255
uniprot id: O26373
names: Similarity
messages: Belongs to the UPF0098 family.

187420:MTH RS02050
gene id: 187420:MTH_RS02050
uniprot id: O26541
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

187420:MTH RS07185
gene id: 187420:MTH_RS07185
uniprot id: O27549
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

187420:MTH RS00260
gene id: 187420:MTH_RS00260
uniprot id: O26158
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate. Is also able to catalyze the reverse reaction in vitro, i.e. the transamination of LL-diaminopimelate with 2-oxoglutarate to produce 2-oxo-6-aminopimelate (in equilibrium with tetrahydrodipicolinate) and glutamate. Has maximal aminotransferase activity using 2-oxoglutarate as an amino group acceptor, and cannot use oxaloacetate instead of 2-oxoglutarate, although 2-oxoadipate can substitute with 21% relative activity. Cannot use m-DAP, lysine or ornithine as the amino-group donor, when using 2-oxoglutarate as the amino-group acceptor.

187420:MTH RS01165
gene id: 187420:MTH_RS01165
uniprot id: P50484
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils.
messages: Chromosome
messages: Cytoplasm
messages: Homodimer or heterodimer with HmtA1 or HmtA2 (PubMed:1459937). Dimers then assemble into higher oligomers, with the DNA wrapped around the protein core (By similarity).

187420:MTH RS05395
gene id: 187420:MTH_RS05395
uniprot id: Q50781
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MvhD/VhuD family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Part of a complex that provides reducing equivalents for heterodisulfide reductase. MvhD may form the contact site to heterodisulfide reductase (By similarity).
messages: The F420-non-reducing hydrogenase is composed of three subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (hdr) (By similarity).

187420:MTH RS05785
gene id: 187420:MTH_RS05785
uniprot id: O27282
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

187420:MTH RS06160
gene id: 187420:MTH_RS06160
uniprot id: O27351
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

187420:MTH RS08170
gene id: 187420:MTH_RS08170
uniprot id: O27740
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS07715
gene id: 187420:MTH_RS07715
uniprot id: O27648
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

187420:MTH RS06755
gene id: 187420:MTH_RS06755
uniprot id: O27463
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Autophosphorylated on a serine. Phosphorylation is stimulated by binding to MCM. Both single-stranded DNA and double-stranded DNA inhibit the phosphorylation reaction.
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication. May play an essential role in origin recognition. Binds to DNA, with a preference for origin-specific double-stranded sequences. Does not bind single-stranded DNA. Inhibits MCM helicase activity but does not affect its oligomeric state.
messages: Monomer. Interacts with MCM via the WH domain.
messages: The N-terminal AAA+ ATPase domain and the C-terminal winged-helix (WH) domain are both required for DNA binding.

187420:MTH RS06250
gene id: 187420:MTH_RS06250
uniprot id: O27365
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

187420:MTH RS08330
gene id: 187420:MTH_RS08330
uniprot id: O27771
names: Cofactor
names: Subunit
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

187420:MTH RS00145
gene id: 187420:MTH_RS00145
uniprot id: O26137
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

187420:MTH RS06615
gene id: 187420:MTH_RS06615
uniprot id: O27436
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity).

187420:MTH RS07305
gene id: 187420:MTH_RS07305
uniprot id: O27572
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

187420:MTH RS01175
gene id: 187420:MTH_RS01175
uniprot id: O26356
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

187420:MTH RS07700
gene id: 187420:MTH_RS07700
uniprot id: O27645
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

187420:MTH RS00985
gene id: 187420:MTH_RS00985
uniprot id: O26320
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

187420:MTH RS02530
gene id: 187420:MTH_RS02530
uniprot id: O26644
names: Similarity
messages: Belongs to the UPF0145 family.

187420:MTH RS08235
gene id: 187420:MTH_RS08235
uniprot id: O27753
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

187420:MTH RS03720
gene id: 187420:MTH_RS03720
uniprot id: O26883
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

187420:MTH RS00655
gene id: 187420:MTH_RS00655
uniprot id: O26249
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
messages: Homotetramer.
messages: Was originally thought to be a precorrin-8w decarboxylase.

187420:MTH RS06375
gene id: 187420:MTH_RS06375
uniprot id: O27390
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

187420:MTH RS03765
gene id: 187420:MTH_RS03765
uniprot id: O26892
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

187420:MTH RS00845
gene id: 187420:MTH_RS00845
uniprot id: O26286
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

187420:MTH RS04485
gene id: 187420:MTH_RS04485
uniprot id: O27030
names: Similarity
messages: Belongs to the UPF0216 family.

187420:MTH RS00035
gene id: 187420:MTH_RS00035
uniprot id: O26115
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

187420:MTH RS00015
gene id: 187420:MTH_RS00015
uniprot id: O26111
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

187420:MTH RS00010
gene id: 187420:MTH_RS00010
uniprot id: O26110
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

187420:MTH RS06505
gene id: 187420:MTH_RS06505
uniprot id: O27414
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS08165
gene id: 187420:MTH_RS08165
uniprot id: O27739
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).

187420:MTH RS03330
gene id: 187420:MTH_RS03330
uniprot id: O26807
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

187420:MTH RS03380
gene id: 187420:MTH_RS03380
uniprot id: O26817
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

187420:MTH RS02685
gene id: 187420:MTH_RS02685
uniprot id: O26679
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

187420:MTH RS07965
gene id: 187420:MTH_RS07965
uniprot id: O27699
names: Similarity
messages: Belongs to the archaeal adenylate kinase family.

187420:MTH RS04975
gene id: 187420:MTH_RS04975
uniprot id: O27124
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Binds 1 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: Part of the RNA polymerase complex.

187420:MTH RS06920
gene id: 187420:MTH_RS06920
uniprot id: O27496
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

187420:MTH RS05260
gene id: 187420:MTH_RS05260
uniprot id: O27180
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

187420:MTH RS01115
gene id: 187420:MTH_RS01115
uniprot id: O26346
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

187420:MTH RS02155
gene id: 187420:MTH_RS02155
uniprot id: O26563
names: Similarity
messages: Belongs to the HepT RNase toxin family.

187420:MTH RS06815
gene id: 187420:MTH_RS06815
uniprot id: O27476
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

187420:MTH RS02795
gene id: 187420:MTH_RS02795
uniprot id: O26702
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

187420:MTH RS02295
gene id: 187420:MTH_RS02295
uniprot id: O26595
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

187420:MTH RS04460
gene id: 187420:MTH_RS04460
uniprot id: O27026
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.
messages: Inhibited by NaCl, KCl, ATP, ADP, GTP and aspartate. Unlike E.coli, not regulated by acetyl-CoA.

187420:MTH RS00175
gene id: 187420:MTH_RS00175
uniprot id: O26142
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

187420:MTH RS07660
gene id: 187420:MTH_RS07660
uniprot id: O27636
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Autophosphorylated on a serine. Phosphorylation is inhibited by binding to MCM. Both single-stranded DNA and double-stranded DNA inhibit the phosphorylation reaction.
messages: Belongs to the CDC6/cdc18 family.
messages: Interacts with MCM.
messages: Involved in regulation of DNA replication. Dissociates the MCM complex and inhibits the MCM helicase activity, suggesting that it may function as a helicase loader. Binds to both specific and random double-stranded or single-stranded DNA.
messages: The N-terminal AAA+ ATPase domain and the C-terminal winged-helix (WH) domain are both required for DNA binding.

187420:MTH RS04965
gene id: 187420:MTH_RS04965
uniprot id: O27122
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

187420:MTH RS06980
gene id: 187420:MTH_RS06980
uniprot id: O27509
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

187420:MTH RS03625
gene id: 187420:MTH_RS03625
uniprot id: O26867
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

187420:MTH RS01265
gene id: 187420:MTH_RS01265
uniprot id: O26375
names: Subcellular Location Annotation
messages: Cell membrane

187420:MTH RS03840
gene id: 187420:MTH_RS03840
uniprot id: O26907
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

187420:MTH RS01085
gene id: 187420:MTH_RS01085
uniprot id: O26340
names: Similarity
messages: To M.jannaschii MJ0658.

187420:MTH RS00095
gene id: 187420:MTH_RS00095
uniprot id: O26127
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

187420:MTH RS00865
gene id: 187420:MTH_RS00865
uniprot id: O26292
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

187420:MTH RS00970
gene id: 187420:MTH_RS00970
uniprot id: O26316
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

187420:MTH RS02630
gene id: 187420:MTH_RS02630
uniprot id: O26666
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

187420:MTH RS06725
gene id: 187420:MTH_RS06725
uniprot id: O27456
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).

187420:MTH RS03730
gene id: 187420:MTH_RS03730
uniprot id: O26885
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

187420:MTH RS07215
gene id: 187420:MTH_RS07215
uniprot id: O27555
names: Function
names: Similarity
messages: Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity).
messages: Belongs to the arsA ATPase family.

187420:MTH RS09190
gene id: 187420:MTH_RS09190
uniprot id: O27936
names: Caution
names: Similarity
messages: Belongs to the UPF0425 family.
messages: Despite a certain similarity to selA, this is not selA (see AC Q57622).

187420:MTH RS07385
gene id: 187420:MTH_RS07385
uniprot id: O27587
names: Function
names: Similarity
names: Subunit
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the phosphorylation of a wide range of nucleosides to yield nucleoside monophosphates, using ATP, ITP or GTP as phosphate donor.
messages: Homodimer.

187420:MTH RS07020
gene id: 187420:MTH_RS07020
uniprot id: O27513
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS07675
gene id: 187420:MTH_RS07675
uniprot id: O27639
names: Similarity
messages: Belongs to the TPP enzyme family.

187420:MTH RS06745
gene id: 187420:MTH_RS06745
uniprot id: O27460
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.

187420:MTH RS00025
gene id: 187420:MTH_RS00025
uniprot id: O26113
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

187420:MTH RS03310
gene id: 187420:MTH_RS03310
uniprot id: O26803
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

187420:MTH RS06835
gene id: 187420:MTH_RS06835
uniprot id: O27481
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

187420:MTH RS00215
gene id: 187420:MTH_RS00215
uniprot id: O26149
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

187420:MTH RS00125
gene id: 187420:MTH_RS00125
uniprot id: O26133
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

187420:MTH RS03120
gene id: 187420:MTH_RS03120
uniprot id: O26765
names: Similarity
messages: Belongs to the HisA/HisF family.

187420:MTH RS09070
gene id: 187420:MTH_RS09070
uniprot id: O27915
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS08435
gene id: 187420:MTH_RS08435
uniprot id: O27786
names: Similarity
messages: Belongs to the phosphohexose mutase family.

187420:MTH RS04205
gene id: 187420:MTH_RS04205
uniprot id: O26977
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.

187420:MTH RS09500
gene id: 187420:MTH_RS09500
uniprot id: O26551
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

187420:MTH RS08850
gene id: 187420:MTH_RS08850
uniprot id: O27875
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

187420:MTH RS08965
gene id: 187420:MTH_RS08965
uniprot id: O27899
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

187420:MTH RS05680
gene id: 187420:MTH_RS05680
uniprot id: O27262
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histone deacetylase family.
messages: Binds 1 zinc ion per subunit.
messages: Probable deacetylase.

187420:MTH RS05215
gene id: 187420:MTH_RS05215
uniprot id: O27170
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

187420:MTH RS08315
gene id: 187420:MTH_RS08315
uniprot id: O27768
names: Similarity
messages: Belongs to the class-I fumarase family.

187420:MTH RS05950
gene id: 187420:MTH_RS05950
uniprot id: O27315
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS07955
gene id: 187420:MTH_RS07955
uniprot id: O27698
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

187420:MTH RS04200
gene id: 187420:MTH_RS04200
uniprot id: O26976
names: Cofactor
names: Similarity
messages: Belongs to the UPF0292 family.
messages: Binds two Mg(2+) per subunit.

187420:MTH RS03695
gene id: 187420:MTH_RS03695
uniprot id: O26880
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity).

187420:MTH RS00180
gene id: 187420:MTH_RS00180
uniprot id: O26143
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

187420:MTH RS08510
gene id: 187420:MTH_RS08510
uniprot id: O27802
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

187420:MTH RS05455
gene id: 187420:MTH_RS05455
uniprot id: O27216
names: Similarity
messages: Belongs to the UPF0254 family.

187420:MTH RS04820
gene id: 187420:MTH_RS04820
uniprot id: O27098
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

187420:MTH RS08875
gene id: 187420:MTH_RS08875
uniprot id: O27881
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

187420:MTH RS05400
gene id: 187420:MTH_RS05400
uniprot id: O27209
names: Similarity
messages: To M.jannaschii MJ0787.

187420:MTH RS03760
gene id: 187420:MTH_RS03760
uniprot id: O26891
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

187420:MTH RS02715
gene id: 187420:MTH_RS02715
uniprot id: O26686
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

187420:MTH RS00185
gene id: 187420:MTH_RS00185
uniprot id: O26144
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.
messages: X-ray crystallography in other archaea shows this protein binds a 3Fe-4S cluster, although a 4Fe-4S cluster has been suggested to be present in this protein.

187420:MTH RS05545
gene id: 187420:MTH_RS05545
uniprot id: O27234
names: Developmental Stage
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.
messages: There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contains mostly MCR I.

187420:MTH RS08015
gene id: 187420:MTH_RS08015
uniprot id: O27710
names: Function
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.
messages: Catalyzes the addition of sulfite to phosphoenolpyruvate (PEP) to yield (2R)-phospho-3-sulfolactate (PSL).

187420:MTH RS07380
gene id: 187420:MTH_RS07380
uniprot id: O27586
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

187420:MTH RS05115
gene id: 187420:MTH_RS05115
uniprot id: O27150
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

187420:MTH RS01025
gene id: 187420:MTH_RS01025
uniprot id: O26328
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.

187420:MTH RS07070
gene id: 187420:MTH_RS07070
uniprot id: O27525
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).

187420:MTH RS01595
gene id: 187420:MTH_RS01595
uniprot id: O26447
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS02950
gene id: 187420:MTH_RS02950
uniprot id: O26731
names: Similarity
messages: Belongs to the UDPGP type 2 family.

187420:MTH RS02020
gene id: 187420:MTH_RS02020
uniprot id: O26535
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

187420:MTH RS07865
gene id: 187420:MTH_RS07865
uniprot id: O27679
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

187420:MTH RS05370
gene id: 187420:MTH_RS05370
uniprot id: Q50485
names: Developmental Stage
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of protein D is not known.
messages: There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contains mostly MCR I.

187420:MTH RS03290
gene id: 187420:MTH_RS03290
uniprot id: O26799
names: Cofactor
names: Subunit
messages: Binds 2 [4Fe-4S] clusters.
messages: Heterotrimer of the VorA, VorB and VorC subunits.

187420:MTH RS05300
gene id: 187420:MTH_RS05300
uniprot id: O27188
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

187420:MTH RS06955
gene id: 187420:MTH_RS06955
uniprot id: O27504
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

187420:MTH RS07650
gene id: 187420:MTH_RS07650
uniprot id: O27634
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Essential for tRNA splicing and maturation. Acts by directly joining spliced tRNA halves to mature-sized tRNAs. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends.
messages: Ligation proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RtcB reacts with GTP to form a covalent RtcB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.
messages: Monomer.

187420:MTH RS06810
gene id: 187420:MTH_RS06810
uniprot id: O27475
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

187420:MTH RS08060
gene id: 187420:MTH_RS08060
uniprot id: O27718
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

187420:MTH RS00940
gene id: 187420:MTH_RS00940
uniprot id: O26310
names: Activity Regulation
names: Function
names: Miscellaneous
names: Subunit
messages: DNA polymerase is inhibited by replication protein A (RPA), while 3'-5' exonuclease activity is not. Polymerase inhibition can be overcome by replication factor C (RFC) and PCNA.
messages: Formed of a complex between PolB1 and PolB2; the exonuclease activity is associated with subunit 1. Probably binds replication protein A (RPA).
messages: In addition to polymerase activity, this DNA polymerase exhibits 3'-5' exonuclease activity.
messages: In some Methanobacteriaceae the PolB protein is split over 2 genes.

187420:MTH RS09035
gene id: 187420:MTH_RS09035
uniprot id: O27913
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

187420:MTH RS06315
gene id: 187420:MTH_RS06315
uniprot id: O27378
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

187420:MTH RS07610
gene id: 187420:MTH_RS07610
uniprot id: O27626
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

187420:MTH RS06680
gene id: 187420:MTH_RS06680
uniprot id: O27447
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

187420:MTH RS05085
gene id: 187420:MTH_RS05085
uniprot id: O27144
names: Similarity
messages: Belongs to the HypD family.

187420:MTH RS06290
gene id: 187420:MTH_RS06290
uniprot id: O27373
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

187420:MTH RS06895
gene id: 187420:MTH_RS06895
uniprot id: O27491
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

187420:MTH RS08195
gene id: 187420:MTH_RS08195
uniprot id: O27745
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

187420:MTH RS03130
gene id: 187420:MTH_RS03130
uniprot id: O26767
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

187420:MTH RS04535
gene id: 187420:MTH_RS04535
uniprot id: O27040
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

187420:MTH RS01215
gene id: 187420:MTH_RS01215
uniprot id: O26364
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

187420:MTH RS09205
gene id: 187420:MTH_RS09205
uniprot id: O27939
names: Activity Regulation
names: Function
names: Subunit
messages: Heterooctamer of four A and four B subunits.
messages: Inhibited by ADP and alpha-ketoglutarate.
messages: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

187420:MTH RS01190
gene id: 187420:MTH_RS01190
uniprot id: O26359
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity).

187420:MTH RS00110
gene id: 187420:MTH_RS00110
uniprot id: O26130
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

187420:MTH RS07165
gene id: 187420:MTH_RS07165
uniprot id: O27544
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

187420:MTH RS07280
gene id: 187420:MTH_RS07280
uniprot id: O27568
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).

187420:MTH RS08055
gene id: 187420:MTH_RS08055
uniprot id: P05394
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

187420:MTH RS00675
gene id: 187420:MTH_RS00675
uniprot id: O26253
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm
messages: Homohexamer.

187420:MTH RS07465
gene id: 187420:MTH_RS07465
uniprot id: O27602
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg-100 inactivates the nitrogenase reductase and regulates nitrogenase activity.

187420:MTH RS04855
gene id: 187420:MTH_RS04855
uniprot id: O27105
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

187420:MTH RS00225
gene id: 187420:MTH_RS00225
uniprot id: O26151
names: Similarity
messages: Belongs to the MEMO1 family.

187420:MTH RS00135
gene id: 187420:MTH_RS00135
uniprot id: O26135
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

187420:MTH RS10025
gene id: 187420:MTH_RS10025
uniprot id: O26656
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

187420:MTH RS06915
gene id: 187420:MTH_RS06915
uniprot id: O27495
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

187420:MTH RS06385
gene id: 187420:MTH_RS06385
uniprot id: O27392
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

187420:MTH RS00455
gene id: 187420:MTH_RS00455
uniprot id: O26206
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux (By similarity).
messages: Homotetramer.

187420:MTH RS03235
gene id: 187420:MTH_RS03235
uniprot id: O26788
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Membrane

187420:MTH RS04110
gene id: 187420:MTH_RS04110
uniprot id: O26957
names: Function
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily. FBPase class 4 family.
messages: Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, and both D and L isomers of inositol-1-phosphate (I-1-P).

187420:MTH RS07935
gene id: 187420:MTH_RS07935
uniprot id: O27694
names: Similarity
messages: Belongs to the TrpC family.

187420:MTH RS07495
gene id: 187420:MTH_RS07495
uniprot id: O27608
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

187420:MTH RS07840
gene id: 187420:MTH_RS07840
uniprot id: O27673
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

187420:MTH RS05065
gene id: 187420:MTH_RS05065
uniprot id: O27140
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

187420:MTH RS04100
gene id: 187420:MTH_RS04100
uniprot id: O26955
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

187420:MTH RS08665
gene id: 187420:MTH_RS08665
uniprot id: O27837
names: Subcellular Location Annotation
messages: Cell membrane

187420:MTH RS03790
gene id: 187420:MTH_RS03790
uniprot id: O26897
names: Similarity
messages: Belongs to the peptidase S49 family.

187420:MTH RS00040
gene id: 187420:MTH_RS00040
uniprot id: O26116
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

187420:MTH RS08045
gene id: 187420:MTH_RS08045
uniprot id: O27716
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

187420:MTH RS03080
gene id: 187420:MTH_RS03080
uniprot id: O26757
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane

187420:MTH RS08125
gene id: 187420:MTH_RS08125
uniprot id: O27732
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

187420:MTH RS08030
gene id: 187420:MTH_RS08030
uniprot id: O27713
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

187420:MTH RS07555
gene id: 187420:MTH_RS07555
uniprot id: O27619
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

187420:MTH RS09130
gene id: 187420:MTH_RS09130
uniprot id: O27924
names: Similarity
messages: Belongs to the UPF0173 family.

187420:MTH RS05770
gene id: 187420:MTH_RS05770
uniprot id: O27279
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Cell membrane

187420:MTH RS00255
gene id: 187420:MTH_RS00255
uniprot id: O26157
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

187420:MTH RS08715
gene id: 187420:MTH_RS08715
uniprot id: O27847
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

187420:MTH RS03180
gene id: 187420:MTH_RS03180
uniprot id: O26777
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

187420:MTH RS05535
gene id: 187420:MTH_RS05535
uniprot id: O27232
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Cytoplasm
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.
messages: The alpha subunit contains six modified amino acids near the active site region. Is methylated on His-257, Arg-271, Gln-400 and Cys-452, probably by the action of specific S-adenosylmethionine-dependent methyltransferases. Also contains a thioglycine at position 445, forming a thiopeptide bond. Contains a didehydroaspartate residue at position 450 (By similarity). The methylation on C5 of Arg-271 is a post-translational methylation not essential in vivo, but which plays a role for the stability and structural integrity of MCR (By similarity).
messages: There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I.

187420:MTH RS07190
gene id: 187420:MTH_RS07190
uniprot id: O27550
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
messages: Cytoplasm
messages: Feedback inhibited by histidine.

187420:MTH RS09100
gene id: 187420:MTH_RS09100
uniprot id: O27920
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

187420:MTH RS08210
gene id: 187420:MTH_RS08210
uniprot id: O27748
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

187420:MTH RS06415
gene id: 187420:MTH_RS06415
uniprot id: O27398
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).

187420:MTH RS07760
gene id: 187420:MTH_RS07760
uniprot id: O27657
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.

187420:MTH RS07735
gene id: 187420:MTH_RS07735
uniprot id: O27652
names: Function
names: Similarity
messages: Belongs to the PDCD5 family.
messages: DNA-binding protein which can interact with a randomly chosen 20-mer of double-stranded DNA.

187420:MTH RS03215
gene id: 187420:MTH_RS03215
uniprot id: O26784
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Constitutively expressed (at protein level).
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

187420:MTH RS05120
gene id: 187420:MTH_RS05120
uniprot id: O27151
names: Similarity
messages: Belongs to the CRISPR-associated Csm4 family.

187420:MTH RS02860
gene id: 187420:MTH_RS02860
uniprot id: O26712
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

187420:MTH RS00920
gene id: 187420:MTH_RS00920
uniprot id: O26305
names: Similarity
messages: Belongs to the DEAD box helicase family.

187420:MTH RS01220
gene id: 187420:MTH_RS01220
uniprot id: O26365
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

187420:MTH RS03195
gene id: 187420:MTH_RS03195
uniprot id: O26780
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

187420:MTH RS04510
gene id: 187420:MTH_RS04510
uniprot id: O27035
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

187420:MTH RS05730
gene id: 187420:MTH_RS05730
uniprot id: O27272
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

187420:MTH RS07620
gene id: 187420:MTH_RS07620
uniprot id: O27628
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

187420:MTH RS05005
gene id: 187420:MTH_RS05005
uniprot id: O27130
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

187420:MTH RS06330
gene id: 187420:MTH_RS06330
uniprot id: O27381
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

187420:MTH RS00055
gene id: 187420:MTH_RS00055
uniprot id: O26119
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Constitutively expressed (at protein level).
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

187420:MTH RS08920
gene id: 187420:MTH_RS08920
uniprot id: O27890
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Binds 1 zinc ion per subunit.
messages: Has 2 structurally independent domains; the N-terminal PINc domain which binds Mn(2+), rRNA substrate and probably has endoribonuclease activity, and the C-terminal zinc ribbon domain which also binds rRNA substrate.
messages: Toxic component of a type II toxin-antitoxin (TA) system. Processes pre-16S-rRNA at its 3' end (the D-site) to yield the mature 3' end (By similarity).

187420:MTH RS08070
gene id: 187420:MTH_RS08070
uniprot id: O27720
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

187420:MTH RS04715
gene id: 187420:MTH_RS04715
uniprot id: O27079
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

187420:MTH RS03795
gene id: 187420:MTH_RS03795
uniprot id: O26898
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts to maintain redox homeostasis; functions as a protein disulfide reductase.
messages: Belongs to the glutaredoxin family.
messages: Cytoplasm

187420:MTH RS00220
gene id: 187420:MTH_RS00220
uniprot id: O26150
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

187420:MTH RS03190
gene id: 187420:MTH_RS03190
uniprot id: O26779
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteromeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

187420:MTH RS06570
gene id: 187420:MTH_RS06570
uniprot id: O27427
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

187420:MTH RS04845
gene id: 187420:MTH_RS04845
uniprot id: O27103
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

187420:MTH RS07475
gene id: 187420:MTH_RS07475
uniprot id: O27604
names: Function
names: Similarity
messages: Belongs to the P(II) protein family.
messages: Could be involved in the regulation of nitrogen fixation.

187420:MTH RS05265
gene id: 187420:MTH_RS05265
uniprot id: O27181
names: Similarity
messages: Belongs to the LarC family.

187420:MTH RS07795
gene id: 187420:MTH_RS07795
uniprot id: O27664
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).

187420:MTH RS05465
gene id: 187420:MTH_RS05465
uniprot id: O27218
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

187420:MTH RS04770
gene id: 187420:MTH_RS04770
uniprot id: O27090
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

187420:MTH RS06460
gene id: 187420:MTH_RS06460
uniprot id: Q50533
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

187420:MTH RS09085
gene id: 187420:MTH_RS09085
uniprot id: O27918
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

187420:MTH RS05495
gene id: 187420:MTH_RS05495
uniprot id: O27224
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

187420:MTH RS07775
gene id: 187420:MTH_RS07775
uniprot id: O27660
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

187420:MTH RS04725
gene id: 187420:MTH_RS04725
uniprot id: O27081
names: Similarity
messages: Belongs to the UPF0146 family.

187420:MTH RS00245
gene id: 187420:MTH_RS00245
uniprot id: O26155
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

187420:MTH RS06020
gene id: 187420:MTH_RS06020
uniprot id: O27329
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Cell membrane

187420:MTH RS08720
gene id: 187420:MTH_RS08720
uniprot id: O27848
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.

187420:MTH RS04565
gene id: 187420:MTH_RS04565
uniprot id: O27046
names: Similarity
messages: Belongs to the PrpD family.

187420:MTH RS03185
gene id: 187420:MTH_RS03185
uniprot id: O26778
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

187420:MTH RS07945
gene id: 187420:MTH_RS07945
uniprot id: O27696
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

187420:MTH RS08120
gene id: 187420:MTH_RS08120
uniprot id: O27731
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compacts DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils.
messages: Chromosome
messages: Cytoplasm
messages: Homodimer or heterodimer with HmtB (By similarity). Dimers then assemble into higher oligomers, with the DNA wrapped around the protein core (By similarity).

187420:MTH RS07345
gene id: 187420:MTH_RS07345
uniprot id: P60461
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer (By similarity).
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex (By similarity).

187420:MTH RS01180
gene id: 187420:MTH_RS01180
uniprot id: O26357
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

187420:MTH RS04980
gene id: 187420:MTH_RS04980
uniprot id: O27125
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: Part of the RNA polymerase complex.

187420:MTH RS03955
gene id: 187420:MTH_RS03955
uniprot id: O26928
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.

187420:MTH RS04520
gene id: 187420:MTH_RS04520
uniprot id: O27037
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

187420:MTH RS06110
gene id: 187420:MTH_RS06110
uniprot id: O27341
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

187420:MTH RS00235
gene id: 187420:MTH_RS00235
uniprot id: O26153
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. Has lower activity with dimethylallyl phosphate (DMAP) and isopentenyl thiolophosphate (ISP). Has low activity with 1-butyl phosphate (BP) and 3-buten-1-yl phosphate (BEP). Has no significant activity with geranyl phosphate (in vitro).
messages: Homodimer.

187420:MTH RS04360
gene id: 187420:MTH_RS04360
uniprot id: O27004
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

187420:MTH RS08105
gene id: 187420:MTH_RS08105
uniprot id: O27728
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity).

187420:MTH RS02835
gene id: 187420:MTH_RS02835
uniprot id: P72010
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Is also able to catalyze the reverse reaction, i.e. the NAD(P)(+)-dependent oxidation of G1P but not of G3P. Is not active toward glycerol, dihydroxyacetone, glyceraldehyde-3-phosphate, glyceraldehyde and glycerol-2-phosphate.
messages: Cytoplasm
messages: G1PDH is a pro-R type dehydrogenase, which selectively transfers the pro-R hydrogen from NADH to dihydroxyacetonephosphate.
messages: Homooctamer.
messages: Partially inhibited by divalent metal cations such as Co(2+), Cu(2+) and Ni(2+).

187420:MTH RS07170
gene id: 187420:MTH_RS07170
uniprot id: O27545
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

187420:MTH RS07705
gene id: 187420:MTH_RS07705
uniprot id: O27646
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

187420:MTH RS06585
gene id: 187420:MTH_RS06585
uniprot id: O27430
names: Similarity
messages: Belongs to the UPF0127 family.

187420:MTH RS02850
gene id: 187420:MTH_RS02850
uniprot id: O26710
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

187420:MTH RS01235
gene id: 187420:MTH_RS01235
uniprot id: O26368
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit.

187420:MTH RS01660
gene id: 187420:MTH_RS01660
uniprot id: O26461
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

187420:MTH RS01570
gene id: 187420:MTH_RS01570
uniprot id: O26442
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS06260
gene id: 187420:MTH_RS06260
uniprot id: O27367
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication (By similarity). In conjunction with replication factor C (RFC) stimulates DNA synthesis by PolB, relieving inhibition by replication protein A (RPA).

187420:MTH RS08755
gene id: 187420:MTH_RS08755
uniprot id: O27855
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

187420:MTH RS00140
gene id: 187420:MTH_RS00140
uniprot id: O26136
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS04810
gene id: 187420:MTH_RS04810
uniprot id: O27096
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

187420:MTH RS05405
gene id: 187420:MTH_RS05405
uniprot id: Q7LYQ2
names: Similarity
messages: Belongs to the MvhD/VhuD family.

187420:MTH RS01035
gene id: 187420:MTH_RS01035
uniprot id: O26330
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

187420:MTH RS08980
gene id: 187420:MTH_RS08980
uniprot id: O27902
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

187420:MTH RS07455
gene id: 187420:MTH_RS07455
uniprot id: O27600
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the FwdC/FmdC family.
messages: By growth on tungsten or molybdenum under anaerobic conditions.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). Can only oxidize formylmethanofuran. This enzyme is oxygen-labile.
messages: Not inactivated by cyanide.
messages: This enzyme is composed of seven subunits FwdA (65 kDa), FwdB (53 kDa), FwdC (31 kDa), FwdD (15 kDa), FwdE, FwdF and FwdG.

187420:MTH RS06650
gene id: 187420:MTH_RS06650
uniprot id: O27443
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

187420:MTH RS07655
gene id: 187420:MTH_RS07655
uniprot id: O27635
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity). May also act as a chaperone or modulator of proteins involved in DNA or RNA processing.
messages: Belongs to the archease family.

187420:MTH RS00750
gene id: 187420:MTH_RS00750
uniprot id: O26267
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

187420:MTH RS02615
gene id: 187420:MTH_RS02615
uniprot id: O26662
names: Function
names: Similarity
messages: Belongs to the HMG-CoA reductase family.
messages: Converts HMG-CoA to mevalonate.

187420:MTH RS06310
gene id: 187420:MTH_RS06310
uniprot id: O27377
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

187420:MTH RS00045
gene id: 187420:MTH_RS00045
uniprot id: O26117
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

187420:MTH RS04825
gene id: 187420:MTH_RS04825
uniprot id: O27099
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

187420:MTH RS02055
gene id: 187420:MTH_RS02055
uniprot id: O26542
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

187420:MTH RS03295
gene id: 187420:MTH_RS03295
uniprot id: O26800
names: Subunit
messages: Heterotrimer of the VorA, VorB and VorC subunits.

187420:MTH RS02300
gene id: 187420:MTH_RS02300
uniprot id: O26596
names: Similarity
messages: Belongs to the Nth/MutY family.

187420:MTH RS08180
gene id: 187420:MTH_RS08180
uniprot id: O27742
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS04745
gene id: 187420:MTH_RS04745
uniprot id: O27085
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).

187420:MTH RS08025
gene id: 187420:MTH_RS08025
uniprot id: O27712
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

187420:MTH RS04895
gene id: 187420:MTH_RS04895
uniprot id: O27113
names: Subunit
messages: Heterotetramer of the KorA, KorB, KorC and KorD subunits.

187420:MTH RS05125
gene id: 187420:MTH_RS05125
uniprot id: O27152
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated Csm3 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities.
messages: Encoded in a type III-A CRISPR locus.
messages: Part of the Csm effector complex that includes Cas10, Csm2, Csm3, Csm4 and Csm5.
messages: This subunit has the target ssRNA endonuclease activity; it cleaves multiple sites in the target RNA at 6 nucleotide intervals.

187420:MTH RS05380
gene id: 187420:MTH_RS05380
uniprot id: Q50784
names: Cofactor
messages: Binds 10 [4Fe-4S] clusters.

187420:MTH RS04140
gene id: 187420:MTH_RS04140
uniprot id: O26963
names: Subcellular Location Annotation
messages: Cell membrane

187420:MTH RS05555
gene id: 187420:MTH_RS05555
uniprot id: O27236
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Cytoplasm
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.
messages: There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I.

187420:MTH RS07825
gene id: 187420:MTH_RS07825
uniprot id: O27670
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

187420:MTH RS01015
gene id: 187420:MTH_RS01015
uniprot id: O26326
names: Similarity
messages: Belongs to the UPF0058 family.

187420:MTH RS07265
gene id: 187420:MTH_RS07265
uniprot id: O27565
names: Similarity
messages: Belongs to the SfsA family.

187420:MTH RS07895
gene id: 187420:MTH_RS07895
uniprot id: O27686
names: Similarity
messages: Belongs to the HupF/HypC family.

187420:MTH RS02135
gene id: 187420:MTH_RS02135
uniprot id: O26560
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

187420:MTH RS01815
gene id: 187420:MTH_RS01815
uniprot id: O26493
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS05795
gene id: 187420:MTH_RS05795
uniprot id: O27284
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

187420:MTH RS05500
gene id: 187420:MTH_RS05500
uniprot id: O27225
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

187420:MTH RS08110
gene id: 187420:MTH_RS08110
uniprot id: O27729
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

187420:MTH RS02215
gene id: 187420:MTH_RS02215
uniprot id: O26576
names: Function
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

187420:MTH RS04150
gene id: 187420:MTH_RS04150
uniprot id: O26965
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

187420:MTH RS04995
gene id: 187420:MTH_RS04995
uniprot id: O27128
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

187420:MTH RS04345
gene id: 187420:MTH_RS04345
uniprot id: O27002
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subunit
messages: By growth on molybdenum, under anaerobic conditions.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). Can only oxidize formylmethanofuran. This enzyme is oxygen-labile.
messages: Consists of five subunits; FmdA, FmdB, FmdC, FmdD, and FmdE.
messages: In the C-terminal section; belongs to the molybdenum dinucleotide binding protein family.
messages: In the N-terminal section; belongs to the FwdC/FmdC family.
messages: Inactivated by cyanide.

187420:MTH RS05020
gene id: 187420:MTH_RS05020
uniprot id: O27133
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

187420:MTH RS04990
gene id: 187420:MTH_RS04990
uniprot id: O27127
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

187420:MTH RS05390
gene id: 187420:MTH_RS05390
uniprot id: Q50782
names: Function
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Part of a complex that provides reducing equivalents for heterodisulfide reductase.
messages: The F420-non-reducing hydrogenase is composed of three subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (hdr) (By similarity).

187420:MTH RS03680
gene id: 187420:MTH_RS03680
uniprot id: O26877
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

187420:MTH RS05310
gene id: 187420:MTH_RS05310
uniprot id: O27191
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

187420:MTH RS05015
gene id: 187420:MTH_RS05015
uniprot id: O27132
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

187420:MTH RS05385
gene id: 187420:MTH_RS05385
uniprot id: Q50783
names: Function
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Part of a complex that provides reducing equivalents for heterodisulfide reductase.
messages: The F420-non-reducing hydrogenase is composed of three subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (hdr) (By similarity).

187420:MTH RS08490
gene id: 187420:MTH_RS08490
uniprot id: O27797
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

187420:MTH RS03545
gene id: 187420:MTH_RS03545
uniprot id: O26851
names: Cofactor
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.

187420:MTH RS00205
gene id: 187420:MTH_RS00205
uniprot id: O26147
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

187420:MTH RS08285
gene id: 187420:MTH_RS08285
uniprot id: O27762
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

187420:MTH RS04180
gene id: 187420:MTH_RS04180
uniprot id: O26971
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

187420:MTH RS06165
gene id: 187420:MTH_RS06165
uniprot id: O27352
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

187420:MTH RS06910
gene id: 187420:MTH_RS06910
uniprot id: O27494
names: Cofactor
names: Similarity
messages: Belongs to the GARS family.
messages: Binds 2 magnesium or manganese ions per subunit.

187420:MTH RS03585
gene id: 187420:MTH_RS03585
uniprot id: O26859
names: Similarity
messages: To M.jannaschii MJ1339.

187420:MTH RS01055
gene id: 187420:MTH_RS01055
uniprot id: O26334
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.

187420:MTH RS05660
gene id: 187420:MTH_RS05660
uniprot id: O27258
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

187420:MTH RS04760
gene id: 187420:MTH_RS04760
uniprot id: O27088
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

187420:MTH RS06040
gene id: 187420:MTH_RS06040
uniprot id: O27333
names: Domain
names: Function
messages: Part of a potassium transport system.
messages: The RCK N-terminal domain binds NAD and possibly other effectors. This is expected to cause a conformation change that regulates potassium transport (By similarity).

187420:MTH RS07810
gene id: 187420:MTH_RS07810
uniprot id: O27667
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of alpha-ketoglutarate and acetyl-CoA to form (R)-homocitrate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)-homo(3)citrate. These reactions are part of the biosynthesis pathway of coenzyme B and biotin.

187420:MTH RS05000
gene id: 187420:MTH_RS05000
uniprot id: O27129
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

187420:MTH RS07480
gene id: 187420:MTH_RS07480
uniprot id: O27605
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [7Fe-Mo-9S-C-homocitryl] cluster per subunit.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

187420:MTH RS06630
gene id: 187420:MTH_RS06630
uniprot id: O27439
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

187420:MTH RS00090
gene id: 187420:MTH_RS00090
uniprot id: O26126
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

187420:MTH RS04000
gene id: 187420:MTH_RS04000
uniprot id: O26937
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

187420:MTH RS03415
gene id: 187420:MTH_RS03415
uniprot id: O26824
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

187420:MTH RS05965
gene id: 187420:MTH_RS05965
uniprot id: O27318
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.jannaschii MJ1223.

187420:MTH RS05735
gene id: 187420:MTH_RS05735
uniprot id: O27273
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDH2/MDH2 oxidoreductase family.
messages: Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate. Involved in the biosynthesis of both coenzyme M (with (R)-sulfolactate) and methanopterin (with alpha-ketoglutarate) (By similarity).
messages: Cytoplasm

187420:MTH RS06675
gene id: 187420:MTH_RS06675
uniprot id: O27446
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

187420:MTH RS02570
gene id: 187420:MTH_RS02570
uniprot id: O26652
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Homotetramer (PubMed:21761520). Homohexamer (PubMed:24684232).
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

187420:MTH RS08445
gene id: 187420:MTH_RS08445
uniprot id: O27788
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

187420:MTH RS07515
gene id: 187420:MTH_RS07515
uniprot id: O27612
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.
messages: Probably involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.

187420:MTH RS09680
gene id: 187420:MTH_RS09680
uniprot id: O27231
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

187420:MTH RS02110
gene id: 187420:MTH_RS02110
uniprot id: O26554
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

187420:MTH RS08400
gene id: 187420:MTH_RS08400
uniprot id: O27784
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm
messages: Increase in abundance from the earliest stages of exponential growth, reaching a maximum level at the mid-exponential growth phase.
messages: Oxygen-stable.

187420:MTH RS03160
gene id: 187420:MTH_RS03160
uniprot id: O26773
names: Similarity
messages: Belongs to the UPF0440 family.

187420:MTH RS00810
gene id: 187420:MTH_RS00810
uniprot id: O26279
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

187420:MTH RS05010
gene id: 187420:MTH_RS05010
uniprot id: O27131
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
messages: Cytoplasm

187420:MTH RS07615
gene id: 187420:MTH_RS07615
uniprot id: O27627
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

187420:MTH RS06440
gene id: 187420:MTH_RS06440
uniprot id: O27402
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

187420:MTH RS01200
gene id: 187420:MTH_RS01200
uniprot id: O26361
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

187420:MTH RS02190
gene id: 187420:MTH_RS02190
uniprot id: O26571
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS05375
gene id: 187420:MTH_RS05375
uniprot id: P21111
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.
messages: There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I.

187420:MTH RS02345
gene id: 187420:MTH_RS02345
uniprot id: O26605
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS04145
gene id: 187420:MTH_RS04145
uniprot id: O26964
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

187420:MTH RS00080
gene id: 187420:MTH_RS00080
uniprot id: O26124
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

187420:MTH RS07210
gene id: 187420:MTH_RS07210
uniprot id: O27554
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

187420:MTH RS01945
gene id: 187420:MTH_RS01945
uniprot id: O26520
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

187420:MTH RS06125
gene id: 187420:MTH_RS06125
uniprot id: O27344
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

187420:MTH RS06635
gene id: 187420:MTH_RS06635
uniprot id: O27440
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

187420:MTH RS03940
gene id: 187420:MTH_RS03940
uniprot id: O26924
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homotetramer; probably dimer of dimers.

187420:MTH RS04640
gene id: 187420:MTH_RS04640
uniprot id: O27061
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

187420:MTH RS04355
gene id: 187420:MTH_RS04355
uniprot id: O27003
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS05550
gene id: 187420:MTH_RS05550
uniprot id: O27235
names: Developmental Stage
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.
messages: There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contains mostly MCR I.

187420:MTH RS02705
gene id: 187420:MTH_RS02705
uniprot id: O26684
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

187420:MTH RS06600
gene id: 187420:MTH_RS06600
uniprot id: O27433
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Cannot use tetrahydrofolate (THF or H4PteGlu) instead of H4MPT as the pteridine substrate. Also probably exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

187420:MTH RS02800
gene id: 187420:MTH_RS02800
uniprot id: O26703
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

187420:MTH RS05715
gene id: 187420:MTH_RS05715
uniprot id: O27269
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

187420:MTH RS06555
gene id: 187420:MTH_RS06555
uniprot id: O27424
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS05720
gene id: 187420:MTH_RS05720
uniprot id: O27270
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

187420:MTH RS08480
gene id: 187420:MTH_RS08480
uniprot id: O27795
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

187420:MTH RS00060
gene id: 187420:MTH_RS00060
uniprot id: O26120
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

187420:MTH RS05150
gene id: 187420:MTH_RS05150
uniprot id: O27157
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

187420:MTH RS04835
gene id: 187420:MTH_RS04835
uniprot id: O27101
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbB/TolQ family.
messages: Cell membrane

187420:MTH RS05510
gene id: 187420:MTH_RS05510
uniprot id: O27227
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

187420:MTH RS04445
gene id: 187420:MTH_RS04445
uniprot id: O27023
names: Similarity
messages: Belongs to the HsdR family.

187420:MTH RS00780
gene id: 187420:MTH_RS00780
uniprot id: O26273
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

187420:MTH RS01225
gene id: 187420:MTH_RS01225
uniprot id: O26366
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

187420:MTH RS02500
gene id: 187420:MTH_RS02500
uniprot id: O26638
names: Function
names: Subunit
messages: Monomer.
messages: Not known. Could have a role in a phosphorylation-independent two-component response regulator system.

187420:MTH RS00945
gene id: 187420:MTH_RS00945
uniprot id: O26311
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

187420:MTH RS08050
gene id: 187420:MTH_RS08050
uniprot id: O27717
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

187420:MTH RS08140
gene id: 187420:MTH_RS08140
uniprot id: O27734
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Binds calcium.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

187420:MTH RS04905
gene id: 187420:MTH_RS04905
uniprot id: O27115
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

187420:MTH RS05650
gene id: 187420:MTH_RS05650
uniprot id: O27256
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

187420:MTH RS07645
gene id: 187420:MTH_RS07645
uniprot id: O27633
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.

187420:MTH RS02580
gene id: 187420:MTH_RS02580
uniprot id: O26654
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm

187420:MTH RS04555
gene id: 187420:MTH_RS04555
uniprot id: O27044
names: Similarity
messages: Belongs to the class-I fumarase family.

187420:MTH RS04070
gene id: 187420:MTH_RS04070
uniprot id: O26951
names: Similarity
messages: To M.jannaschii MJ1453.

187420:MTH RS07990
gene id: 187420:MTH_RS07990
uniprot id: O27705
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer (By similarity). Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with RNA polymerase in the absence of Tbp or DNA promoter. Interacts both with the preinitiation and elongation complexes (By similarity).
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

187420:MTH RS07755
gene id: 187420:MTH_RS07755
uniprot id: O27656
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

187420:MTH RS05360
gene id: 187420:MTH_RS05360
uniprot id: P21110
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.
messages: The alpha subunit contains six modified amino acids near the active site region. Is methylated on His-260, Arg-274, Gln-402 and Cys-454, probably by the action of specific S-adenosylmethionine-dependent methyltransferases. Also contains a thioglycine at position 447, forming a thiopeptide bond. Contains a didehydroaspartate residue at position 452 (By similarity). The methylation on C5 of Arg-274 is a post-translational methylation not essential in vivo, but which plays a role for the stability and structural integrity of MCR (By similarity).
messages: There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contain mostly MCR I.

187420:MTH RS02700
gene id: 187420:MTH_RS02700
uniprot id: O26683
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

187420:MTH RS01210
gene id: 187420:MTH_RS01210
uniprot id: O26363
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

187420:MTH RS05750
gene id: 187420:MTH_RS05750
uniprot id: O27276
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-B family.
messages: DNA polymerase is inhibited by replication protein A (RPA), while 3'-5' exonuclease activity is not. Polymerase inhibition can be overcome by replication factor C (RFC) and PCNA.
messages: Formed of a complex between PolB1 and PolB2; the exonuclease activity is associated with subunit 1. Probably binds replication protein A (RPA).
messages: In addition to polymerase activity, this DNA polymerase exhibits 3'-5' exonuclease activity.
messages: In some Methanobacteriaceae the PolB protein is split over 2 genes.

187420:MTH RS03865
gene id: 187420:MTH_RS03865
uniprot id: P50483
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compacts DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils.
messages: Chromosome
messages: Cytoplasm
messages: Homodimer or heterodimer with HmtB (PubMed:1459937). Dimers then assemble into higher oligomers, with the DNA wrapped around the protein core (By similarity).

187420:MTH RS03210
gene id: 187420:MTH_RS03210
uniprot id: O26783
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Constitutively expressed (at protein level).
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

187420:MTH RS05970
gene id: 187420:MTH_RS05970
uniprot id: O27319
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

187420:MTH RS00840
gene id: 187420:MTH_RS00840
uniprot id: O26285
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

187420:MTH RS07310
gene id: 187420:MTH_RS07310
uniprot id: O27573
names: Similarity
messages: Belongs to the UPF0107 family.

187420:MTH RS07545
gene id: 187420:MTH_RS07545
uniprot id: O27617
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

187420:MTH RS06795
gene id: 187420:MTH_RS06795
uniprot id: O27472
names: Similarity
messages: To M.jannaschii MJ1313.

187420:MTH RS04035
gene id: 187420:MTH_RS04035
uniprot id: O26944
names: Function
names: Similarity
messages: Belongs to the peptidase U62 family.
messages: Probable metalloprotease.

187420:MTH RS02610
gene id: 187420:MTH_RS02610
uniprot id: O26661
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS03635
gene id: 187420:MTH_RS03635
uniprot id: O26869
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate.

187420:MTH RS07000
gene id: 187420:MTH_RS07000
uniprot id: Q50501
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

187420:MTH RS03165
gene id: 187420:MTH_RS03165
uniprot id: O26774
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

187420:MTH RS01865
gene id: 187420:MTH_RS01865
uniprot id: O26504
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

187420:MTH RS03610
gene id: 187420:MTH_RS03610
uniprot id: O26864
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

187420:MTH RS07405
gene id: 187420:MTH_RS07405
uniprot id: O27591
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.

187420:MTH RS03205
gene id: 187420:MTH_RS03205
uniprot id: O26782
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

187420:MTH RS04635
gene id: 187420:MTH_RS04635
uniprot id: O27060
names: Subcellular Location Annotation
messages: Membrane

187420:MTH RS06715
gene id: 187420:MTH_RS06715
uniprot id: O27454
names: Function
names: Similarity
messages: Belongs to the precorrin methyltransferase family.
messages: Methyltransferase that likely catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV. May also convert cobalt-precorrin-3 to cobalt-precorrin-4 (By similarity).

187420:MTH RS01740
gene id: 187420:MTH_RS01740
uniprot id: O26478
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Cell membrane

187420:MTH RS03960
gene id: 187420:MTH_RS03960
uniprot id: O26929
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Cell membrane

187420:MTH RS04095
gene id: 187420:MTH_RS04095
uniprot id: O26954
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

187420:MTH RS02575
gene id: 187420:MTH_RS02575
uniprot id: O26653
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

187420:MTH RS06245
gene id: 187420:MTH_RS06245
uniprot id: O27364
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

187420:MTH RS08160
gene id: 187420:MTH_RS08160
uniprot id: O27738
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

187420:MTH RS03395
gene id: 187420:MTH_RS03395
uniprot id: O26820
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. Trm-G10 family.
messages: Catalyzes the adenosylmethionine-dependent methylation of the exocyclic amino group (N(2)) of guanosine at position 10 of various tRNAs. Acts via a two-step process that leads to the formation of either N(2)-monomethyl (m(2)G) or N(2)-dimethylguanosine (m(2)(2)G) (By similarity).
messages: Cytoplasm
messages: Monomer.

187420:MTH RS07930
gene id: 187420:MTH_RS07930
uniprot id: O27693
names: Function
names: Subunit
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).

187420:MTH RS04350
gene id: 187420:MTH_RS04350
uniprot id: Q1MVQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

187420:MTH RS03770
gene id: 187420:MTH_RS03770
uniprot id: O26893
names: Similarity
messages: Belongs to the aspartokinase family.

187420:MTH RS02510
gene id: 187420:MTH_RS02510
uniprot id: O26640
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

187420:MTH RS03035
gene id: 187420:MTH_RS03035
uniprot id: O26748
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

187420:MTH RS00960
gene id: 187420:MTH_RS00960
uniprot id: O26314
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the DNA repair enzymes AP/exoA family.
messages: Can also use Mn(2+), Co(2+) and Ni(2+).
messages: Depletion leads to the loss of DNA-U repair.
messages: Involved in DNA uracil repair (PubMed:17012282, PubMed:19240141, PubMed:20129830). Recognizes DNA uracil residues within double-stranded DNA and initiates DNA-U repair by endonucleotic incision on the 5'-side of the 2'-d-uridine residue, irrespective of the nature of the opposing nucleotide (PubMed:17012282, PubMed:19240141, PubMed:20129830). In addition, acts as an apurinic/apyrimidinic (AP) endonuclease hydrolyzing the DNA phosphodiester backbone immediately at the 5'-side of AP sites, and as a 3'-5' exonuclease (PubMed:15725624, PubMed:17012282). Strongly binds to double-stranded DNA (PubMed:15725624).
messages: The insertion of the side chain of Arg-209 into the DNA helical base stack seems to be crucial for the uridine recognition.

187420:MTH RS04085
gene id: 187420:MTH_RS04085
uniprot id: O26952
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

187420:MTH RS08780
gene id: 187420:MTH_RS08780
uniprot id: O27860
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

187420:MTH RS00075
gene id: 187420:MTH_RS00075
uniprot id: O26123
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

187420:MTH RS08770
gene id: 187420:MTH_RS08770
uniprot id: O27858
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

187420:MTH RS06605
gene id: 187420:MTH_RS06605
uniprot id: O27434
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Binds 4 [4Fe-4S] clusters per subunit.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC. It forms a complex with the F420-non-reducing hydrogenase (Mvh), which provides the reducing equivalents to the heterodisulfide reductase.

187420:MTH RS02665
gene id: 187420:MTH_RS02665
uniprot id: O26674
names: Similarity
messages: Belongs to the flavoredoxin family.