1873524:HSR6 RS04015
gene id: 1873524:HSR6_RS04015
uniprot id: A0A1J1AAV2
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

1873524:HSR6 RS09555
gene id: 1873524:HSR6_RS09555
uniprot id: A0A1J1AEW6
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS05355
gene id: 1873524:HSR6_RS05355
uniprot id: A0A1J1ACN9
names: Subcellular Location Annotation
messages: Cytoplasm

1873524:HSR6 RS08360
gene id: 1873524:HSR6_RS08360
uniprot id: A0A1D8S603
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS04390
gene id: 1873524:HSR6_RS04390
uniprot id: A0A1D8S3X2
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1873524:HSR6 RS09220
gene id: 1873524:HSR6_RS09220
uniprot id: A0A1J1ADR0
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1873524:HSR6 RS09965
gene id: 1873524:HSR6_RS09965
uniprot id: A0A1J1AE50
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

1873524:HSR6 RS06300
gene id: 1873524:HSR6_RS06300
uniprot id: A0A1J1AC43
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1873524:HSR6 RS05950
gene id: 1873524:HSR6_RS05950
uniprot id: A0A1D8S4Q5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

1873524:HSR6 RS02145
gene id: 1873524:HSR6_RS02145
uniprot id: A0A1J1A9U4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1873524:HSR6 RS04435
gene id: 1873524:HSR6_RS04435
uniprot id: A0A1J1AB36
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1873524:HSR6 RS03500
gene id: 1873524:HSR6_RS03500
uniprot id: A0A1D8S3E3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

1873524:HSR6 RS10465
gene id: 1873524:HSR6_RS10465
uniprot id: A0A1D8S745
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

1873524:HSR6 RS06965
gene id: 1873524:HSR6_RS06965
uniprot id: A0A1J1ACG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

1873524:HSR6 RS05220
gene id: 1873524:HSR6_RS05220
uniprot id: A0A1D8S4B3
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

1873524:HSR6 RS04490
gene id: 1873524:HSR6_RS04490
uniprot id: A0A1J1AC54
names: Similarity
messages: Belongs to the UPF0173 family.

1873524:HSR6 RS00455
gene id: 1873524:HSR6_RS00455
uniprot id: A0A1J1A8X7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1873524:HSR6 RS06280
gene id: 1873524:HSR6_RS06280
uniprot id: A0A1J1ADP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1873524:HSR6 RS02130
gene id: 1873524:HSR6_RS02130
uniprot id: A0A1J1ABE6
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS10485
gene id: 1873524:HSR6_RS10485
uniprot id: A0A1J1AEG9
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

1873524:HSR6 RS04060
gene id: 1873524:HSR6_RS04060
uniprot id: A0A1J1ABM5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS07040
gene id: 1873524:HSR6_RS07040
uniprot id: A0A1J1AD85
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS09850
gene id: 1873524:HSR6_RS09850
uniprot id: A0A1J1AEQ1
names: Similarity
messages: Belongs to the UPF0215 family.

1873524:HSR6 RS02770
gene id: 1873524:HSR6_RS02770
uniprot id: A0A1J1ABA8
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS03865
gene id: 1873524:HSR6_RS03865
uniprot id: A0A1D8S3L2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

1873524:HSR6 RS03950
gene id: 1873524:HSR6_RS03950
uniprot id: A0A1D8S3M6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

1873524:HSR6 RS08085
gene id: 1873524:HSR6_RS08085
uniprot id: A0A1D8S5U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1873524:HSR6 RS07975
gene id: 1873524:HSR6_RS07975
uniprot id: A0A1D8S5S0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1873524:HSR6 RS03275
gene id: 1873524:HSR6_RS03275
uniprot id: A0A1D8S3B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

1873524:HSR6 RS05030
gene id: 1873524:HSR6_RS05030
uniprot id: A0A1J1ACI0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

1873524:HSR6 RS03445
gene id: 1873524:HSR6_RS03445
uniprot id: A0A1D8S3D9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS03860
gene id: 1873524:HSR6_RS03860
uniprot id: A0A1D8S3L0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1873524:HSR6 RS01170
gene id: 1873524:HSR6_RS01170
uniprot id: A0A1J1A9B9
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS07415
gene id: 1873524:HSR6_RS07415
uniprot id: A0A1D8S5G4
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS10250
gene id: 1873524:HSR6_RS10250
uniprot id: A0A1D8S6Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

1873524:HSR6 RS03345
gene id: 1873524:HSR6_RS03345
uniprot id: A0A1D8S3C0
names: Similarity
messages: Belongs to the HypE family.

1873524:HSR6 RS05750
gene id: 1873524:HSR6_RS05750
uniprot id: A0A1D8S4M4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS05180
gene id: 1873524:HSR6_RS05180
uniprot id: A0A1J1AC89
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS04585
gene id: 1873524:HSR6_RS04585
uniprot id: A0A1J1ACC8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

1873524:HSR6 RS07495
gene id: 1873524:HSR6_RS07495
uniprot id: A0A1D8S5I7
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

1873524:HSR6 RS02865
gene id: 1873524:HSR6_RS02865
uniprot id: A0A1D8S355
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1873524:HSR6 RS01175
gene id: 1873524:HSR6_RS01175
uniprot id: A0A1J1A9Z1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

1873524:HSR6 RS09600
gene id: 1873524:HSR6_RS09600
uniprot id: A0A1D8S6M3
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

1873524:HSR6 RS09700
gene id: 1873524:HSR6_RS09700
uniprot id: A0A1D8S6P6
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1873524:HSR6 RS01760
gene id: 1873524:HSR6_RS01760
uniprot id: A0A1D8S2L6
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS06810
gene id: 1873524:HSR6_RS06810
uniprot id: A0A1J1ACD5
names: Similarity
messages: Belongs to the anthranilate synthase component I family.
messages: Belongs to the isochorismate synthase family.

1873524:HSR6 RS01640
gene id: 1873524:HSR6_RS01640
uniprot id: A0A1D8S2F8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1873524:HSR6 RS04415
gene id: 1873524:HSR6_RS04415
uniprot id: A0A1J1AB33
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1873524:HSR6 RS00635
gene id: 1873524:HSR6_RS00635
uniprot id: A0A1D8S1V3
names: Similarity
messages: Belongs to the PdaD family.

1873524:HSR6 RS09395
gene id: 1873524:HSR6_RS09395
uniprot id: A0A1D8S6J0
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1873524:HSR6 RS10015
gene id: 1873524:HSR6_RS10015
uniprot id: A0A1J1AE57
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1873524:HSR6 RS06875
gene id: 1873524:HSR6_RS06875
uniprot id: A0A1J1AD53
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS01820
gene id: 1873524:HSR6_RS01820
uniprot id: A0A1J1A9P0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS01620
gene id: 1873524:HSR6_RS01620
uniprot id: A0A1D8S2I7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

1873524:HSR6 RS07000
gene id: 1873524:HSR6_RS07000
uniprot id: A0A1D8S573
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1873524:HSR6 RS01245
gene id: 1873524:HSR6_RS01245
uniprot id: A0A1D8S287
names: Similarity
messages: Belongs to the HypE family.

1873524:HSR6 RS00630
gene id: 1873524:HSR6_RS00630
uniprot id: A0A1D8S1V7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

1873524:HSR6 RS02905
gene id: 1873524:HSR6_RS02905
uniprot id: A0A1J1ABU6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

1873524:HSR6 RS10685
gene id: 1873524:HSR6_RS10685
uniprot id: A0A1J1AEK6
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS02860
gene id: 1873524:HSR6_RS02860
uniprot id: A0A1J1AB63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1873524:HSR6 RS03415
gene id: 1873524:HSR6_RS03415
uniprot id: A0A1J1AAH8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS10420
gene id: 1873524:HSR6_RS10420
uniprot id: A0A1J1AEZ4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1873524:HSR6 RS09390
gene id: 1873524:HSR6_RS09390
uniprot id: A0A1D8S6I4
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1873524:HSR6 RS09100
gene id: 1873524:HSR6_RS09100
uniprot id: A0A1D8S6F4
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1873524:HSR6 RS07555
gene id: 1873524:HSR6_RS07555
uniprot id: A0A1D8S5H9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1873524:HSR6 RS02575
gene id: 1873524:HSR6_RS02575
uniprot id: A0A1D8S2Z3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

1873524:HSR6 RS10565
gene id: 1873524:HSR6_RS10565
uniprot id: A0A1J1AEI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1873524:HSR6 RS10475
gene id: 1873524:HSR6_RS10475
uniprot id: A0A1D8S771
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS07010
gene id: 1873524:HSR6_RS07010
uniprot id: A0A1J1ADP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1873524:HSR6 RS09080
gene id: 1873524:HSR6_RS09080
uniprot id: A0A1J1ADM7
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

1873524:HSR6 RS01510
gene id: 1873524:HSR6_RS01510
uniprot id: A0A1D8S2C9
names: Subcellular Location Annotation
messages: Cell membrane

1873524:HSR6 RS04335
gene id: 1873524:HSR6_RS04335
uniprot id: A0A1J1AB19
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

1873524:HSR6 RS02805
gene id: 1873524:HSR6_RS02805
uniprot id: A0A1J1AAW9
names: Function
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
messages: Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC), the main low-molecular-weight thiol compound instead of glutathione in halophilic archaea.

1873524:HSR6 RS08100
gene id: 1873524:HSR6_RS08100
uniprot id: A0A1J1AD43
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS09380
gene id: 1873524:HSR6_RS09380
uniprot id: A0A1J1ADT0
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

1873524:HSR6 RS03425
gene id: 1873524:HSR6_RS03425
uniprot id: A0A1J1ABH9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in both the arginine and lysine biosynthetic pathways.

1873524:HSR6 RS10725
gene id: 1873524:HSR6_RS10725
uniprot id: A0A1D8S7B2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS10720
gene id: 1873524:HSR6_RS10720
uniprot id: A0A1J1AFG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1873524:HSR6 RS02825
gene id: 1873524:HSR6_RS02825
uniprot id: A0A1D8S348
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

1873524:HSR6 RS09575
gene id: 1873524:HSR6_RS09575
uniprot id: A0A1J1AF71
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1873524:HSR6 RS07440
gene id: 1873524:HSR6_RS07440
uniprot id: A0A1J1ADG3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for chromosome condensation and partitioning.

1873524:HSR6 RS07720
gene id: 1873524:HSR6_RS07720
uniprot id: A0A1D8S5L8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1873524:HSR6 RS01610
gene id: 1873524:HSR6_RS01610
uniprot id: A0A1D8S2I4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

1873524:HSR6 RS07905
gene id: 1873524:HSR6_RS07905
uniprot id: A0A1J1AE46
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1873524:HSR6 RS08010
gene id: 1873524:HSR6_RS08010
uniprot id: A0A1D8S5R6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1873524:HSR6 RS03960
gene id: 1873524:HSR6_RS03960
uniprot id: A0A1D8S3Q8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1873524:HSR6 RS01590
gene id: 1873524:HSR6_RS01590
uniprot id: A0A1D8S2E8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

1873524:HSR6 RS09880
gene id: 1873524:HSR6_RS09880
uniprot id: A0A1D8S6S4
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS01395
gene id: 1873524:HSR6_RS01395
uniprot id: A0A1D8S2B1
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1873524:HSR6 RS08695
gene id: 1873524:HSR6_RS08695
uniprot id: A0A1J1AF13
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

1873524:HSR6 RS03495
gene id: 1873524:HSR6_RS03495
uniprot id: A0A1J1AAJ4
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

1873524:HSR6 RS02635
gene id: 1873524:HSR6_RS02635
uniprot id: A0A1D8S324
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS04395
gene id: 1873524:HSR6_RS04395
uniprot id: A0A1J1AB30
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1873524:HSR6 RS01325
gene id: 1873524:HSR6_RS01325
uniprot id: A0A1D8S2A3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

1873524:HSR6 RS06015
gene id: 1873524:HSR6_RS06015
uniprot id: A0A1D8S4S9
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS05080
gene id: 1873524:HSR6_RS05080
uniprot id: A0A1J1ABG6
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1873524:HSR6 RS01305
gene id: 1873524:HSR6_RS01305
uniprot id: A0A1D8S2C7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS07340
gene id: 1873524:HSR6_RS07340
uniprot id: A0A1D8S5E5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

1873524:HSR6 RS00650
gene id: 1873524:HSR6_RS00650
uniprot id: A0A1J1AAL7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

1873524:HSR6 RS06680
gene id: 1873524:HSR6_RS06680
uniprot id: A0A1D8S507
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

1873524:HSR6 RS06850
gene id: 1873524:HSR6_RS06850
uniprot id: A0A1D8S552
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1873524:HSR6 RS03750
gene id: 1873524:HSR6_RS03750
uniprot id: A0A1J1ABR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

1873524:HSR6 RS03710
gene id: 1873524:HSR6_RS03710
uniprot id: A0A1J1ABQ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1873524:HSR6 RS07540
gene id: 1873524:HSR6_RS07540
uniprot id: A0A1J1AEE9
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

1873524:HSR6 RS09185
gene id: 1873524:HSR6_RS09185
uniprot id: A0A1J1AEY7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS00865
gene id: 1873524:HSR6_RS00865
uniprot id: A0A1J1AA57
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1873524:HSR6 RS05505
gene id: 1873524:HSR6_RS05505
uniprot id: A0A1J1ABN5
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

1873524:HSR6 RS02190
gene id: 1873524:HSR6_RS02190
uniprot id: A0A1D8S2S3
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS00685
gene id: 1873524:HSR6_RS00685
uniprot id: A0A1D8S1W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

1873524:HSR6 RS05260
gene id: 1873524:HSR6_RS05260
uniprot id: A0A1D8S4C0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS01025
gene id: 1873524:HSR6_RS01025
uniprot id: A0A1D8S241
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

1873524:HSR6 RS00145
gene id: 1873524:HSR6_RS00145
uniprot id: A0A1J1A8R2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS06060
gene id: 1873524:HSR6_RS06060
uniprot id: A0A1D8S4T2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1873524:HSR6 RS01600
gene id: 1873524:HSR6_RS01600
uniprot id: A0A1D8S2F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1873524:HSR6 RS01330
gene id: 1873524:HSR6_RS01330
uniprot id: A0A1D8S2B2
names: Similarity
messages: Belongs to the PspA/IM30 family.

1873524:HSR6 RS00060
gene id: 1873524:HSR6_RS00060
uniprot id: A0A1J1AA94
names: Similarity
messages: Belongs to the beta-eliminating lyase family.

1873524:HSR6 RS01650
gene id: 1873524:HSR6_RS01650
uniprot id: A0A1D8S2G2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1873524:HSR6 RS05055
gene id: 1873524:HSR6_RS05055
uniprot id: A0A1J1AC67
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1873524:HSR6 RS09270
gene id: 1873524:HSR6_RS09270
uniprot id: A0A1D8S6H0
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS00125
gene id: 1873524:HSR6_RS00125
uniprot id: A0A1D8S1I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

1873524:HSR6 RS10260
gene id: 1873524:HSR6_RS10260
uniprot id: A0A1J1AEA8
names: Similarity
messages: Belongs to the thymidylate kinase family.

1873524:HSR6 RS03760
gene id: 1873524:HSR6_RS03760
uniprot id: A0A1J1ABP6
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1873524:HSR6 RS01950
gene id: 1873524:HSR6_RS01950
uniprot id: A0A1D8S2M6
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1873524:HSR6 RS00340
gene id: 1873524:HSR6_RS00340
uniprot id: A0A1J1A9T9
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS05375
gene id: 1873524:HSR6_RS05375
uniprot id: A0A1D8S4F2
names: Similarity
messages: Belongs to the HypE family.

1873524:HSR6 RS05245
gene id: 1873524:HSR6_RS05245
uniprot id: A0A1J1ABJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1873524:HSR6 RS02295
gene id: 1873524:HSR6_RS02295
uniprot id: A0A1D8S2V0
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

1873524:HSR6 RS09325
gene id: 1873524:HSR6_RS09325
uniprot id: A0A1D8S6J4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

1873524:HSR6 RS07420
gene id: 1873524:HSR6_RS07420
uniprot id: A0A1J1AEC4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1873524:HSR6 RS09870
gene id: 1873524:HSR6_RS09870
uniprot id: A0A1D8S6T0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS03660
gene id: 1873524:HSR6_RS03660
uniprot id: A0A1J1ABT3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1873524:HSR6 RS01290
gene id: 1873524:HSR6_RS01290
uniprot id: A0A1D8S286
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1873524:HSR6 RS06975
gene id: 1873524:HSR6_RS06975
uniprot id: A0A1J1ADK1
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS09740
gene id: 1873524:HSR6_RS09740
uniprot id: A0A1J1AF45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

1873524:HSR6 RS01250
gene id: 1873524:HSR6_RS01250
uniprot id: A0A1J1A9D8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1873524:HSR6 RS04175
gene id: 1873524:HSR6_RS04175
uniprot id: A0A1J1AAY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1873524:HSR6 RS10360
gene id: 1873524:HSR6_RS10360
uniprot id: A0A1D8S732
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS06930
gene id: 1873524:HSR6_RS06930
uniprot id: A0A1J1ADJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1873524:HSR6 RS10345
gene id: 1873524:HSR6_RS10345
uniprot id: A0A1J1AFP1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

1873524:HSR6 RS00030
gene id: 1873524:HSR6_RS00030
uniprot id: A0A1D8S1I9
names: Similarity
messages: Belongs to the aspartokinase family.

1873524:HSR6 RS02585
gene id: 1873524:HSR6_RS02585
uniprot id: A0A1J1ABN9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1873524:HSR6 RS04930
gene id: 1873524:HSR6_RS04930
uniprot id: A0A1J1ABD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1873524:HSR6 RS07315
gene id: 1873524:HSR6_RS07315
uniprot id: A0A1D8S5E4
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS03805
gene id: 1873524:HSR6_RS03805
uniprot id: A0A1J1AAR2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

1873524:HSR6 RS05840
gene id: 1873524:HSR6_RS05840
uniprot id: A0A1D8S4N6
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

1873524:HSR6 RS09845
gene id: 1873524:HSR6_RS09845
uniprot id: A0A1J1AE27
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

1873524:HSR6 RS02925
gene id: 1873524:HSR6_RS02925
uniprot id: A0A1D8S374
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1873524:HSR6 RS02460
gene id: 1873524:HSR6_RS02460
uniprot id: A0A1D8S301
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1873524:HSR6 RS05725
gene id: 1873524:HSR6_RS05725
uniprot id: A0A1J1ACZ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS00135
gene id: 1873524:HSR6_RS00135
uniprot id: A0A1D8S1K4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1873524:HSR6 RS05500
gene id: 1873524:HSR6_RS05500
uniprot id: A0A1J1ACQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1873524:HSR6 RS09340
gene id: 1873524:HSR6_RS09340
uniprot id: A0A1D8S6G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1873524:HSR6 RS07550
gene id: 1873524:HSR6_RS07550
uniprot id: A0A1J1ADU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1873524:HSR6 RS04055
gene id: 1873524:HSR6_RS04055
uniprot id: A0A1J1AAW2
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS10670
gene id: 1873524:HSR6_RS10670
uniprot id: A0A1J1AG22
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1873524:HSR6 RS06920
gene id: 1873524:HSR6_RS06920
uniprot id: A0A1J1ACF9
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS02000
gene id: 1873524:HSR6_RS02000
uniprot id: A0A1D8S2N3
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

1873524:HSR6 RS01810
gene id: 1873524:HSR6_RS01810
uniprot id: A0A1D8S2M4
names: Similarity
messages: Belongs to the LeuD family. LeuD type 2 subfamily.

1873524:HSR6 RS10220
gene id: 1873524:HSR6_RS10220
uniprot id: A0A1D8S715
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1873524:HSR6 RS04580
gene id: 1873524:HSR6_RS04580
uniprot id: A0A1J1AB69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1873524:HSR6 RS03935
gene id: 1873524:HSR6_RS03935
uniprot id: A0A1J1AAT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1873524:HSR6 RS05800
gene id: 1873524:HSR6_RS05800
uniprot id: A0A1D8S4N5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

1873524:HSR6 RS08425
gene id: 1873524:HSR6_RS08425
uniprot id: A0A1J1AEI4
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

1873524:HSR6 RS03820
gene id: 1873524:HSR6_RS03820
uniprot id: A0A1J1ABW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1873524:HSR6 RS06870
gene id: 1873524:HSR6_RS06870
uniprot id: A0A1J1ACD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1873524:HSR6 RS00175
gene id: 1873524:HSR6_RS00175
uniprot id: A0A1D8S1L4
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

1873524:HSR6 RS03900
gene id: 1873524:HSR6_RS03900
uniprot id: A0A1D8S3M1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Homodimer.

1873524:HSR6 RS04975
gene id: 1873524:HSR6_RS04975
uniprot id: A0A1J1ABE2
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

1873524:HSR6 RS03985
gene id: 1873524:HSR6_RS03985
uniprot id: A0A1J1AAU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1873524:HSR6 RS04165
gene id: 1873524:HSR6_RS04165
uniprot id: A0A1J1ABZ4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1873524:HSR6 RS05370
gene id: 1873524:HSR6_RS05370
uniprot id: A0A1D8S4E5
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

1873524:HSR6 RS03245
gene id: 1873524:HSR6_RS03245
uniprot id: A0A1J1AB66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS05365
gene id: 1873524:HSR6_RS05365
uniprot id: A0A1D8S4E7
names: Subunit
messages: Homotetramer.

1873524:HSR6 RS02890
gene id: 1873524:HSR6_RS02890
uniprot id: A0A1J1AA78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1873524:HSR6 RS06820
gene id: 1873524:HSR6_RS06820
uniprot id: A0A1D8S546
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS09830
gene id: 1873524:HSR6_RS09830
uniprot id: A0A1J1AFM4
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

1873524:HSR6 RS02360
gene id: 1873524:HSR6_RS02360
uniprot id: A0A1D8S2Y3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

1873524:HSR6 RS07900
gene id: 1873524:HSR6_RS07900
uniprot id: A0A1J1AE71
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

1873524:HSR6 RS06045
gene id: 1873524:HSR6_RS06045
uniprot id: A0A1J1AD63
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

1873524:HSR6 RS09675
gene id: 1873524:HSR6_RS09675
uniprot id: A0A1J1AEZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1873524:HSR6 RS09410
gene id: 1873524:HSR6_RS09410
uniprot id: A0A1J1AEZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

1873524:HSR6 RS08545
gene id: 1873524:HSR6_RS08545
uniprot id: A0A1J1ADC3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS00600
gene id: 1873524:HSR6_RS00600
uniprot id: A0A1J1A9M0
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS06080
gene id: 1873524:HSR6_RS06080
uniprot id: A0A1J1AD72
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1873524:HSR6 RS10010
gene id: 1873524:HSR6_RS10010
uniprot id: A0A1J1AES4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1873524:HSR6 RS01670
gene id: 1873524:HSR6_RS01670
uniprot id: A0A1D8S2J7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1873524:HSR6 RS05955
gene id: 1873524:HSR6_RS05955
uniprot id: A0A1D8S4Q8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS04180
gene id: 1873524:HSR6_RS04180
uniprot id: A0A1D8S3S6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1873524:HSR6 RS04635
gene id: 1873524:HSR6_RS04635
uniprot id: A0A1D8S427
names: Function
messages: Part of a potassium transport system.

1873524:HSR6 RS05475
gene id: 1873524:HSR6_RS05475
uniprot id: A0A1J1ABN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

1873524:HSR6 RS02355
gene id: 1873524:HSR6_RS02355
uniprot id: A0A1J1A9X8
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

1873524:HSR6 RS01495
gene id: 1873524:HSR6_RS01495
uniprot id: A0A1D8S2D7
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

1873524:HSR6 RS04120
gene id: 1873524:HSR6_RS04120
uniprot id: A0A1D8S3Q9
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS01665
gene id: 1873524:HSR6_RS01665
uniprot id: A0A1D8S2F9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1873524:HSR6 RS06825
gene id: 1873524:HSR6_RS06825
uniprot id: A0A1D8S536
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

1873524:HSR6 RS03195
gene id: 1873524:HSR6_RS03195
uniprot id: A0A1J1AAD9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1873524:HSR6 RS01485
gene id: 1873524:HSR6_RS01485
uniprot id: A0A1D8S2C4
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

1873524:HSR6 RS02275
gene id: 1873524:HSR6_RS02275
uniprot id: A0A1J1AAK7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS05580
gene id: 1873524:HSR6_RS05580
uniprot id: A0A1D8S4I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1873524:HSR6 RS09995
gene id: 1873524:HSR6_RS09995
uniprot id: A0A1J1AE47
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS02205
gene id: 1873524:HSR6_RS02205
uniprot id: A0A1J1AAZ8
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS07430
gene id: 1873524:HSR6_RS07430
uniprot id: A0A1J1ADS4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1873524:HSR6 RS03825
gene id: 1873524:HSR6_RS03825
uniprot id: A0A1J1ABS5
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

1873524:HSR6 RS07330
gene id: 1873524:HSR6_RS07330
uniprot id: A0A1D8S5E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1873524:HSR6 RS04305
gene id: 1873524:HSR6_RS04305
uniprot id: A0A1J1ABR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1873524:HSR6 RS07730
gene id: 1873524:HSR6_RS07730
uniprot id: A0A1D8S5M0
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

1873524:HSR6 RS03100
gene id: 1873524:HSR6_RS03100
uniprot id: A0A1J1ABB3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1873524:HSR6 RS09770
gene id: 1873524:HSR6_RS09770
uniprot id: A0A1D8S6S1
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

1873524:HSR6 RS07215
gene id: 1873524:HSR6_RS07215
uniprot id: A0A1J1ADP8
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

1873524:HSR6 RS07795
gene id: 1873524:HSR6_RS07795
uniprot id: A0A1D8S5M9
names: Similarity
messages: Belongs to the UPF0440 family.

1873524:HSR6 RS03080
gene id: 1873524:HSR6_RS03080
uniprot id: A0A1J1AAB8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1873524:HSR6 RS10695
gene id: 1873524:HSR6_RS10695
uniprot id: A0A1D8S779
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1873524:HSR6 RS04920
gene id: 1873524:HSR6_RS04920
uniprot id: A0A1J1ACF6
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS06955
gene id: 1873524:HSR6_RS06955
uniprot id: A0A1D8S562
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

1873524:HSR6 RS00285
gene id: 1873524:HSR6_RS00285
uniprot id: A0A1J1A9P6
names: Similarity
messages: Belongs to the HMBS family.

1873524:HSR6 RS07715
gene id: 1873524:HSR6_RS07715
uniprot id: A0A1D8S5M5
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

1873524:HSR6 RS04330
gene id: 1873524:HSR6_RS04330
uniprot id: A0A1J1ACL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

1873524:HSR6 RS08490
gene id: 1873524:HSR6_RS08490
uniprot id: A0A1J1AD99
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1873524:HSR6 RS02535
gene id: 1873524:HSR6_RS02535
uniprot id: A0A1J1AB61
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1873524:HSR6 RS02410
gene id: 1873524:HSR6_RS02410
uniprot id: A0A1D8S2Z4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1873524:HSR6 RS01095
gene id: 1873524:HSR6_RS01095
uniprot id: A0A1J1A9A4
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1873524:HSR6 RS10500
gene id: 1873524:HSR6_RS10500
uniprot id: A0A1D8S749
names: Subcellular Location Annotation
messages: Cytoplasm

1873524:HSR6 RS05035
gene id: 1873524:HSR6_RS05035
uniprot id: A0A1J1AD18
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

1873524:HSR6 RS00805
gene id: 1873524:HSR6_RS00805
uniprot id: A0A1D8S1Z4
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

1873524:HSR6 RS07670
gene id: 1873524:HSR6_RS07670
uniprot id: A0A1J1ACV4
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS00525
gene id: 1873524:HSR6_RS00525
uniprot id: A0A1D8S1T5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS07335
gene id: 1873524:HSR6_RS07335
uniprot id: A0A1D8S5F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

1873524:HSR6 RS09330
gene id: 1873524:HSR6_RS09330
uniprot id: A0A1D8S6I2
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

1873524:HSR6 RS07990
gene id: 1873524:HSR6_RS07990
uniprot id: A0A1D8S5T2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

1873524:HSR6 RS08025
gene id: 1873524:HSR6_RS08025
uniprot id: A0A1D8S5T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1873524:HSR6 RS03015
gene id: 1873524:HSR6_RS03015
uniprot id: A0A1J1AAA1
names: Similarity
messages: Belongs to the UPF0175 family.

1873524:HSR6 RS09475
gene id: 1873524:HSR6_RS09475
uniprot id: A0A1D8S6N1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

1873524:HSR6 RS06010
gene id: 1873524:HSR6_RS06010
uniprot id: A0A1D8S4S1
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS05530
gene id: 1873524:HSR6_RS05530
uniprot id: A0A1D8S4H1
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS06140
gene id: 1873524:HSR6_RS06140
uniprot id: A0A1J1AC10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1873524:HSR6 RS01630
gene id: 1873524:HSR6_RS01630
uniprot id: A0A1D8S2G3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

1873524:HSR6 RS00740
gene id: 1873524:HSR6_RS00740
uniprot id: A0A1J1A934
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS03830
gene id: 1873524:HSR6_RS03830
uniprot id: A0A1J1ACC6
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1873524:HSR6 RS03555
gene id: 1873524:HSR6_RS03555
uniprot id: A0A1D8S3G5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS00345
gene id: 1873524:HSR6_RS00345
uniprot id: A0A1J1A8V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

1873524:HSR6 RS10665
gene id: 1873524:HSR6_RS10665
uniprot id: A0A1D8S784
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

1873524:HSR6 RS06760
gene id: 1873524:HSR6_RS06760
uniprot id: A0A1J1ACB8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS03480
gene id: 1873524:HSR6_RS03480
uniprot id: A0A1J1ABK2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

1873524:HSR6 RS06640
gene id: 1873524:HSR6_RS06640
uniprot id: A0A1D8S505
names: Similarity
messages: Belongs to the UPF0045 family.

1873524:HSR6 RS06500
gene id: 1873524:HSR6_RS06500
uniprot id: A0A1D8S4W2
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS01770
gene id: 1873524:HSR6_RS01770
uniprot id: A0A1D8S2L7
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS09865
gene id: 1873524:HSR6_RS09865
uniprot id: A0A1D8S6T1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

1873524:HSR6 RS01360
gene id: 1873524:HSR6_RS01360
uniprot id: A0A1D8S299
names: Similarity
messages: Belongs to the MoaB/Mog family.

1873524:HSR6 RS09035
gene id: 1873524:HSR6_RS09035
uniprot id: A0A1J1AF72
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

1873524:HSR6 RS02745
gene id: 1873524:HSR6_RS02745
uniprot id: A0A1J1ABR4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1873524:HSR6 RS07195
gene id: 1873524:HSR6_RS07195
uniprot id: A0A1D8S5C8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

1873524:HSR6 RS03595
gene id: 1873524:HSR6_RS03595
uniprot id: A0A1J1AC73
names: Similarity
messages: Belongs to the acylphosphatase family.

1873524:HSR6 RS10555
gene id: 1873524:HSR6_RS10555
uniprot id: A0A1J1AEH3
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

1873524:HSR6 RS10515
gene id: 1873524:HSR6_RS10515
uniprot id: A0A1J1AEG4
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

1873524:HSR6 RS01280
gene id: 1873524:HSR6_RS01280
uniprot id: A0A1D8S2A4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1873524:HSR6 RS09335
gene id: 1873524:HSR6_RS09335
uniprot id: A0A1J1AFD1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

1873524:HSR6 RS01300
gene id: 1873524:HSR6_RS01300
uniprot id: A0A1D8S2B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

1873524:HSR6 RS00755
gene id: 1873524:HSR6_RS00755
uniprot id: A0A1J1A9Q9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1873524:HSR6 RS08575
gene id: 1873524:HSR6_RS08575
uniprot id: A0A1D8S649
names: Subcellular Location Annotation
messages: Cytoplasm

1873524:HSR6 RS05215
gene id: 1873524:HSR6_RS05215
uniprot id: A0A1D8S4B8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1873524:HSR6 RS03705
gene id: 1873524:HSR6_RS03705
uniprot id: A0A1J1ABU1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

1873524:HSR6 RS09940
gene id: 1873524:HSR6_RS09940
uniprot id: A0A1D8S6W6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

1873524:HSR6 RS01140
gene id: 1873524:HSR6_RS01140
uniprot id: A0A1D8S267
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1873524:HSR6 RS00920
gene id: 1873524:HSR6_RS00920
uniprot id: A0A1D8S216
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

1873524:HSR6 RS00255
gene id: 1873524:HSR6_RS00255
uniprot id: A0A1D8S1M7
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS03460
gene id: 1873524:HSR6_RS03460
uniprot id: A0A1J1ABN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1873524:HSR6 RS01885
gene id: 1873524:HSR6_RS01885
uniprot id: A0A1J1AAT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1873524:HSR6 RS06275
gene id: 1873524:HSR6_RS06275
uniprot id: A0A1J1AD67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1873524:HSR6 RS07995
gene id: 1873524:HSR6_RS07995
uniprot id: A0A1D8S5S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

1873524:HSR6 RS05850
gene id: 1873524:HSR6_RS05850
uniprot id: A0A1J1ACY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

1873524:HSR6 RS10000
gene id: 1873524:HSR6_RS10000
uniprot id: A0A1J1AF53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ModE family.
messages: Membrane

1873524:HSR6 RS05985
gene id: 1873524:HSR6_RS05985
uniprot id: A0A1D8S4Q6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1873524:HSR6 RS02030
gene id: 1873524:HSR6_RS02030
uniprot id: A0A1J1A9S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1873524:HSR6 RS00765
gene id: 1873524:HSR6_RS00765
uniprot id: A0A1D8S1Y7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1873524:HSR6 RS08895
gene id: 1873524:HSR6_RS08895
uniprot id: A0A1J1AEN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1873524:HSR6 RS00595
gene id: 1873524:HSR6_RS00595
uniprot id: A0A1J1A907
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1873524:HSR6 RS01120
gene id: 1873524:HSR6_RS01120
uniprot id: A0A1D8S257
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.

1873524:HSR6 RS07525
gene id: 1873524:HSR6_RS07525
uniprot id: A0A1D8S5I1
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

1873524:HSR6 RS06420
gene id: 1873524:HSR6_RS06420
uniprot id: A0A1D8S4W8
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS07490
gene id: 1873524:HSR6_RS07490
uniprot id: A0A1J1ADZ2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS01800
gene id: 1873524:HSR6_RS01800
uniprot id: A0A1J1A9L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1873524:HSR6 RS03250
gene id: 1873524:HSR6_RS03250
uniprot id: A0A1D8S390
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS09405
gene id: 1873524:HSR6_RS09405
uniprot id: A0A1D8S6J7
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS05495
gene id: 1873524:HSR6_RS05495
uniprot id: A0A1J1ABP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1873524:HSR6 RS03920
gene id: 1873524:HSR6_RS03920
uniprot id: A0A1D8S3N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1873524:HSR6 RS00065
gene id: 1873524:HSR6_RS00065
uniprot id: A0A1J1A8P8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1873524:HSR6 RS09400
gene id: 1873524:HSR6_RS09400
uniprot id: A0A1D8S6I5
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1873524:HSR6 RS07055
gene id: 1873524:HSR6_RS07055
uniprot id: A0A1D8S581
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

1873524:HSR6 RS08380
gene id: 1873524:HSR6_RS08380
uniprot id: A0A1J1AD97
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1873524:HSR6 RS09075
gene id: 1873524:HSR6_RS09075
uniprot id: A0A1D8S6C8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1873524:HSR6 RS00860
gene id: 1873524:HSR6_RS00860
uniprot id: A0A1J1A970
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS08510
gene id: 1873524:HSR6_RS08510
uniprot id: A0A1J1AE14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1873524:HSR6 RS08325
gene id: 1873524:HSR6_RS08325
uniprot id: A0A1J1AD68
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

1873524:HSR6 RS00395
gene id: 1873524:HSR6_RS00395
uniprot id: A0A1J1A8W1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

1873524:HSR6 RS02835
gene id: 1873524:HSR6_RS02835
uniprot id: A0A1D8S343
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1873524:HSR6 RS07375
gene id: 1873524:HSR6_RS07375
uniprot id: A0A1D8S5F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

1873524:HSR6 RS03075
gene id: 1873524:HSR6_RS03075
uniprot id: A0A1J1ABC1
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1873524:HSR6 RS08655
gene id: 1873524:HSR6_RS08655
uniprot id: A0A1D8S651
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1873524:HSR6 RS05635
gene id: 1873524:HSR6_RS05635
uniprot id: A0A1J1ABS2
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1873524:HSR6 RS08420
gene id: 1873524:HSR6_RS08420
uniprot id: A0A1J1ADA6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1873524:HSR6 RS07470
gene id: 1873524:HSR6_RS07470
uniprot id: A0A1J1ADT2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1873524:HSR6 RS09950
gene id: 1873524:HSR6_RS09950
uniprot id: A0A1D8S6V6
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

1873524:HSR6 RS09775
gene id: 1873524:HSR6_RS09775
uniprot id: A0A1J1AFB6
names: Similarity
messages: Belongs to the RutC family.

1873524:HSR6 RS10370
gene id: 1873524:HSR6_RS10370
uniprot id: A0A1J1AED7
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1873524:HSR6 RS08445
gene id: 1873524:HSR6_RS08445
uniprot id: A0A1J1AEB5
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

1873524:HSR6 RS06705
gene id: 1873524:HSR6_RS06705
uniprot id: A0A1J1ADY1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1873524:HSR6 RS03150
gene id: 1873524:HSR6_RS03150
uniprot id: A0A1J1ABY9
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS07880
gene id: 1873524:HSR6_RS07880
uniprot id: A0A1D8S5Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1873524:HSR6 RS01660
gene id: 1873524:HSR6_RS01660
uniprot id: A0A1D8S2J6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1873524:HSR6 RS03430
gene id: 1873524:HSR6_RS03430
uniprot id: A0A1J1AC39
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

1873524:HSR6 RS05805
gene id: 1873524:HSR6_RS05805
uniprot id: A0A1D8S4N2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

1873524:HSR6 RS07035
gene id: 1873524:HSR6_RS07035
uniprot id: A0A1J1ACG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

1873524:HSR6 RS01565
gene id: 1873524:HSR6_RS01565
uniprot id: A0A1J1AAM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1873524:HSR6 RS06815
gene id: 1873524:HSR6_RS06815
uniprot id: A0A1J1ADK6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

1873524:HSR6 RS10540
gene id: 1873524:HSR6_RS10540
uniprot id: A0A1J1AFT8
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1873524:HSR6 RS09765
gene id: 1873524:HSR6_RS09765
uniprot id: A0A1J1AEN1
names: Similarity
messages: Belongs to the citrate synthase family.

1873524:HSR6 RS00180
gene id: 1873524:HSR6_RS00180
uniprot id: A0A1J1A8S0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

1873524:HSR6 RS09695
gene id: 1873524:HSR6_RS09695
uniprot id: A0A1J1AF92
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1873524:HSR6 RS07225
gene id: 1873524:HSR6_RS07225
uniprot id: A0A1D8S5C1
names: Function
names: Subunit
messages: Interacts with chemotaxis (Che) proteins as well as flagella accessory (Fla) proteins.
messages: Involved in taxis signal transduction.

1873524:HSR6 RS07745
gene id: 1873524:HSR6_RS07745
uniprot id: A0A1D8S5L9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

1873524:HSR6 RS01815
gene id: 1873524:HSR6_RS01815
uniprot id: A0A1J1AB85
names: Function
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

1873524:HSR6 RS00760
gene id: 1873524:HSR6_RS00760
uniprot id: A0A1J1A941
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS05350
gene id: 1873524:HSR6_RS05350
uniprot id: A0A1J1ACT1
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

1873524:HSR6 RS01985
gene id: 1873524:HSR6_RS01985
uniprot id: A0A1D8S2P0
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

1873524:HSR6 RS09470
gene id: 1873524:HSR6_RS09470
uniprot id: A0A1J1AEU9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS03525
gene id: 1873524:HSR6_RS03525
uniprot id: A0A1D8S3E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

1873524:HSR6 RS02495
gene id: 1873524:HSR6_RS02495
uniprot id: A0A1D8S2Y6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1873524:HSR6 RS01110
gene id: 1873524:HSR6_RS01110
uniprot id: A0A1J1AAE2
names: Similarity
messages: Belongs to the HerA family.

1873524:HSR6 RS00300
gene id: 1873524:HSR6_RS00300
uniprot id: A0A1D8S1N6
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1873524:HSR6 RS03785
gene id: 1873524:HSR6_RS03785
uniprot id: A0A1J1ABR8
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

1873524:HSR6 RS06115
gene id: 1873524:HSR6_RS06115
uniprot id: A0A1D8S4V3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1873524:HSR6 RS06085
gene id: 1873524:HSR6_RS06085
uniprot id: A0A1J1AD34
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

1873524:HSR6 RS09160
gene id: 1873524:HSR6_RS09160
uniprot id: A0A1J1ADP3
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

1873524:HSR6 RS09530
gene id: 1873524:HSR6_RS09530
uniprot id: A0A1J1ADW5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

1873524:HSR6 RS09975
gene id: 1873524:HSR6_RS09975
uniprot id: A0A1D8S6U8
names: Similarity
messages: Belongs to the HAM1 NTPase family.

1873524:HSR6 RS00290
gene id: 1873524:HSR6_RS00290
uniprot id: A0A1J1AAE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

1873524:HSR6 RS00120
gene id: 1873524:HSR6_RS00120
uniprot id: A0A1D8S1L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

1873524:HSR6 RS04470
gene id: 1873524:HSR6_RS04470
uniprot id: A0A1J1ACA7
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1873524:HSR6 RS06865
gene id: 1873524:HSR6_RS06865
uniprot id: A0A1D8S542
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1873524:HSR6 RS02765
gene id: 1873524:HSR6_RS02765
uniprot id: A0A1J1AA51
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1873524:HSR6 RS06565
gene id: 1873524:HSR6_RS06565
uniprot id: A0A1J1AC86
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1873524:HSR6 RS04610
gene id: 1873524:HSR6_RS04610
uniprot id: A0A1J1AB75
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS00780
gene id: 1873524:HSR6_RS00780
uniprot id: A0A1D8S1X6
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

1873524:HSR6 RS00365
gene id: 1873524:HSR6_RS00365
uniprot id: A0A1J1A9R3
names: Similarity
messages: Belongs to the IMPACT family.

1873524:HSR6 RS09790
gene id: 1873524:HSR6_RS09790
uniprot id: A0A1J1AFL4
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1873524:HSR6 RS01615
gene id: 1873524:HSR6_RS01615
uniprot id: A0A1J1AB47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1873524:HSR6 RS09885
gene id: 1873524:HSR6_RS09885
uniprot id: A0A1J1AE36
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

1873524:HSR6 RS05310
gene id: 1873524:HSR6_RS05310
uniprot id: A0A1J1ACS3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1873524:HSR6 RS03380
gene id: 1873524:HSR6_RS03380
uniprot id: A0A1D8S3E0
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

1873524:HSR6 RS05990
gene id: 1873524:HSR6_RS05990
uniprot id: A0A1D8S4R9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1873524:HSR6 RS03315
gene id: 1873524:HSR6_RS03315
uniprot id: A0A1D8S3B4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS10550
gene id: 1873524:HSR6_RS10550
uniprot id: A0A1D8S757
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

1873524:HSR6 RS08485
gene id: 1873524:HSR6_RS08485
uniprot id: A0A1J1AEX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH.
messages: Homotetramer.

1873524:HSR6 RS02955
gene id: 1873524:HSR6_RS02955
uniprot id: A0A1J1AB99
names: Similarity
messages: Belongs to the GARS family.

1873524:HSR6 RS09065
gene id: 1873524:HSR6_RS09065
uniprot id: A0A1D8S6D3
names: Similarity
messages: Belongs to the MtrH family.

1873524:HSR6 RS00800
gene id: 1873524:HSR6_RS00800
uniprot id: A0A1J1A947
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

1873524:HSR6 RS03280
gene id: 1873524:HSR6_RS03280
uniprot id: A0A1D8S389
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

1873524:HSR6 RS00070
gene id: 1873524:HSR6_RS00070
uniprot id: A0A1J1A9N2
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

1873524:HSR6 RS01420
gene id: 1873524:HSR6_RS01420
uniprot id: A0A1D8S2B5
names: Subcellular Location Annotation
messages: Cytoplasm

1873524:HSR6 RS09515
gene id: 1873524:HSR6_RS09515
uniprot id: A0A1D8S6M0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1873524:HSR6 RS07775
gene id: 1873524:HSR6_RS07775
uniprot id: A0A1D8S5P3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1873524:HSR6 RS06845
gene id: 1873524:HSR6_RS06845
uniprot id: A0A1D8S541
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1873524:HSR6 RS04290
gene id: 1873524:HSR6_RS04290
uniprot id: A0A1J1AB10
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.
messages: Membrane

1873524:HSR6 RS10205
gene id: 1873524:HSR6_RS10205
uniprot id: A0A1D8S6Y7
names: Similarity
messages: Belongs to the AOR/FOR family.

1873524:HSR6 RS04205
gene id: 1873524:HSR6_RS04205
uniprot id: A0A1J1ACJ3
names: Similarity
messages: Belongs to the UPF0212 family.

1873524:HSR6 RS00100
gene id: 1873524:HSR6_RS00100
uniprot id: A0A1J1AAA4
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS03340
gene id: 1873524:HSR6_RS03340
uniprot id: A0A1J1ABG1
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1873524:HSR6 RS02910
gene id: 1873524:HSR6_RS02910
uniprot id: A0A1D8S367
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

1873524:HSR6 RS03470
gene id: 1873524:HSR6_RS03470
uniprot id: A0A1J1AC49
names: Similarity
messages: Belongs to the Nth/MutY family.

1873524:HSR6 RS00785
gene id: 1873524:HSR6_RS00785
uniprot id: A0A1J1AA41
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1873524:HSR6 RS10215
gene id: 1873524:HSR6_RS10215
uniprot id: A0A1J1AEV3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1873524:HSR6 RS05515
gene id: 1873524:HSR6_RS05515
uniprot id: A0A1J1ABP9
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1873524:HSR6 RS01690
gene id: 1873524:HSR6_RS01690
uniprot id: A0A1J1AAI8
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS04070
gene id: 1873524:HSR6_RS04070
uniprot id: A0A1J1AC19
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1873524:HSR6 RS06995
gene id: 1873524:HSR6_RS06995
uniprot id: A0A1D8S587
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1873524:HSR6 RS07370
gene id: 1873524:HSR6_RS07370
uniprot id: A0A1D8S5E9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1873524:HSR6 RS08780
gene id: 1873524:HSR6_RS08780
uniprot id: A0A1J1ADF9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

1873524:HSR6 RS01595
gene id: 1873524:HSR6_RS01595
uniprot id: A0A1D8S2E4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1873524:HSR6 RS09265
gene id: 1873524:HSR6_RS09265
uniprot id: A0A1J1ADR9
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

1873524:HSR6 RS00825
gene id: 1873524:HSR6_RS00825
uniprot id: A0A1J1AA50
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

1873524:HSR6 RS02095
gene id: 1873524:HSR6_RS02095
uniprot id: A0A1D8S2Q3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1873524:HSR6 RS07770
gene id: 1873524:HSR6_RS07770
uniprot id: A0A1D8S5N1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1873524:HSR6 RS01990
gene id: 1873524:HSR6_RS01990
uniprot id: A0A1J1A9R6
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1873524:HSR6 RS09450
gene id: 1873524:HSR6_RS09450
uniprot id: A0A1D8S6K0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1873524:HSR6 RS00895
gene id: 1873524:HSR6_RS00895
uniprot id: A0A1J1AAS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

1873524:HSR6 RS09385
gene id: 1873524:HSR6_RS09385
uniprot id: A0A1D8S6K1
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

1873524:HSR6 RS01190
gene id: 1873524:HSR6_RS01190
uniprot id: A0A1J1AA89
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

1873524:HSR6 RS03915
gene id: 1873524:HSR6_RS03915
uniprot id: A0A1D8S3N1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1873524:HSR6 RS08830
gene id: 1873524:HSR6_RS08830
uniprot id: A0A1J1AEH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1873524:HSR6 RS06570
gene id: 1873524:HSR6_RS06570
uniprot id: A0A1D8S4Y7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

1873524:HSR6 RS10580
gene id: 1873524:HSR6_RS10580
uniprot id: A0A1J1AFV5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1873524:HSR6 RS02565
gene id: 1873524:HSR6_RS02565
uniprot id: A0A1J1AAR4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS02100
gene id: 1873524:HSR6_RS02100
uniprot id: A0A1D8S2Q9
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

1873524:HSR6 RS01900
gene id: 1873524:HSR6_RS01900
uniprot id: A0A1J1A9Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

1873524:HSR6 RS04565
gene id: 1873524:HSR6_RS04565
uniprot id: A0A1J1AC71
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

1873524:HSR6 RS03895
gene id: 1873524:HSR6_RS03895
uniprot id: A0A1D8S3M3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

1873524:HSR6 RS07560
gene id: 1873524:HSR6_RS07560
uniprot id: A0A1J1ADI1
names: Similarity
messages: Belongs to the TrpC family.

1873524:HSR6 RS01625
gene id: 1873524:HSR6_RS01625
uniprot id: A0A1D8S2F5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1873524:HSR6 RS07325
gene id: 1873524:HSR6_RS07325
uniprot id: A0A1J1ACN6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

1873524:HSR6 RS08305
gene id: 1873524:HSR6_RS08305
uniprot id: A0A1J1AD81
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS00465
gene id: 1873524:HSR6_RS00465
uniprot id: A0A1J1A8X4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1873524:HSR6 RS04590
gene id: 1873524:HSR6_RS04590
uniprot id: A0A1D8S422
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

1873524:HSR6 RS05275
gene id: 1873524:HSR6_RS05275
uniprot id: A0A1D8S4C9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS01465
gene id: 1873524:HSR6_RS01465
uniprot id: A0A1J1AA44
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1873524:HSR6 RS02185
gene id: 1873524:HSR6_RS02185
uniprot id: A0A1D8S2S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

1873524:HSR6 RS00830
gene id: 1873524:HSR6_RS00830
uniprot id: A0A1J1A957
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1873524:HSR6 RS06710
gene id: 1873524:HSR6_RS06710
uniprot id: A0A1D8S519
names: Subcellular Location Annotation
messages: Cytoplasm

1873524:HSR6 RS01675
gene id: 1873524:HSR6_RS01675
uniprot id: A0A1D8S2G5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1873524:HSR6 RS06860
gene id: 1873524:HSR6_RS06860
uniprot id: A0A1J1ADH9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1873524:HSR6 RS08015
gene id: 1873524:HSR6_RS08015
uniprot id: A0A1D8S5S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1873524:HSR6 RS01570
gene id: 1873524:HSR6_RS01570
uniprot id: A0A1D8S2H7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

1873524:HSR6 RS02965
gene id: 1873524:HSR6_RS02965
uniprot id: A0A1J1AB03
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

1873524:HSR6 RS05325
gene id: 1873524:HSR6_RS05325
uniprot id: A0A1D8S4E1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1873524:HSR6 RS05645
gene id: 1873524:HSR6_RS05645
uniprot id: A0A1J1ACU8
names: Similarity
messages: Belongs to the DNA photolyase family.

1873524:HSR6 RS06175
gene id: 1873524:HSR6_RS06175
uniprot id: A0A1J1AD51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the halobacterial S-layer protein family.
messages: Cell membrane
messages: Membrane
messages: S-layer

1873524:HSR6 RS07310
gene id: 1873524:HSR6_RS07310
uniprot id: A0A1D8S5D0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

1873524:HSR6 RS03670
gene id: 1873524:HSR6_RS03670
uniprot id: A0A1D8S3I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

1873524:HSR6 RS00220
gene id: 1873524:HSR6_RS00220
uniprot id: A0A1J1A8S8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS07790
gene id: 1873524:HSR6_RS07790
uniprot id: A0A1D8S5Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1873524:HSR6 RS05490
gene id: 1873524:HSR6_RS05490
uniprot id: A0A1D8S4F6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

1873524:HSR6 RS10545
gene id: 1873524:HSR6_RS10545
uniprot id: A0A1D8S753
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

1873524:HSR6 RS00875
gene id: 1873524:HSR6_RS00875
uniprot id: A0A1J1A9T8
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: The active site is a redox-active disulfide bond.

1873524:HSR6 RS08000
gene id: 1873524:HSR6_RS08000
uniprot id: A0A1D8S5T6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

1873524:HSR6 RS01365
gene id: 1873524:HSR6_RS01365
uniprot id: A0A1D8S2D6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS08250
gene id: 1873524:HSR6_RS08250
uniprot id: A0A1D8S5Y4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS01980
gene id: 1873524:HSR6_RS01980
uniprot id: A0A1D8S2N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

1873524:HSR6 RS06540
gene id: 1873524:HSR6_RS06540
uniprot id: A0A1J1ADU6
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

1873524:HSR6 RS03730
gene id: 1873524:HSR6_RS03730
uniprot id: A0A1D8S3I8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1873524:HSR6 RS02260
gene id: 1873524:HSR6_RS02260
uniprot id: A0A1J1ADY1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1873524:HSR6 RS03875
gene id: 1873524:HSR6_RS03875
uniprot id: A0A1D8S3L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

1873524:HSR6 RS10115
gene id: 1873524:HSR6_RS10115
uniprot id: A0A1J1AFB8
names: Similarity
messages: Belongs to the SUI1 family.

1873524:HSR6 RS03765
gene id: 1873524:HSR6_RS03765
uniprot id: A0A1D8S3J2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1873524:HSR6 RS02725
gene id: 1873524:HSR6_RS02725
uniprot id: A0A1J1AAV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1873524:HSR6 RS10630
gene id: 1873524:HSR6_RS10630
uniprot id: A0A1D8S775
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1873524:HSR6 RS10705
gene id: 1873524:HSR6_RS10705
uniprot id: A0A1D8S7A0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1873524:HSR6 RS05650
gene id: 1873524:HSR6_RS05650
uniprot id: A0A1D8S4L0
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1873524:HSR6 RS00745
gene id: 1873524:HSR6_RS00745
uniprot id: A0A1D8S1Y0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1873524:HSR6 RS09930
gene id: 1873524:HSR6_RS09930
uniprot id: A0A1D8S6T6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1873524:HSR6 RS01905
gene id: 1873524:HSR6_RS01905
uniprot id: A0A1J1AAP2
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1873524:HSR6 RS08915
gene id: 1873524:HSR6_RS08915
uniprot id: A0A1J1AEI9
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1873524:HSR6 RS05600
gene id: 1873524:HSR6_RS05600
uniprot id: A0A1J1ACX5
names: Similarity
messages: Belongs to the MEMO1 family.

1873524:HSR6 RS03930
gene id: 1873524:HSR6_RS03930
uniprot id: A0A1D8S3N2
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1873524:HSR6 RS07250
gene id: 1873524:HSR6_RS07250
uniprot id: A0A1J1ADU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

1873524:HSR6 RS06070
gene id: 1873524:HSR6_RS06070
uniprot id: A0A1J1AC00
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS07475
gene id: 1873524:HSR6_RS07475
uniprot id: A0A1J1ACR1
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

1873524:HSR6 RS03320
gene id: 1873524:HSR6_RS03320
uniprot id: A0A1D8S3A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1873524:HSR6 RS00155
gene id: 1873524:HSR6_RS00155
uniprot id: A0A1D8S1J9
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1873524:HSR6 RS02795
gene id: 1873524:HSR6_RS02795
uniprot id: A0A1D8S333
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1873524:HSR6 RS08515
gene id: 1873524:HSR6_RS08515
uniprot id: A0A1J1ADC2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS07450
gene id: 1873524:HSR6_RS07450
uniprot id: A0A1J1ADY4
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase involved in purine salvage.

1873524:HSR6 RS02530
gene id: 1873524:HSR6_RS02530
uniprot id: A0A1J1AA04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1873524:HSR6 RS10675
gene id: 1873524:HSR6_RS10675
uniprot id: A0A1J1AEJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1873524:HSR6 RS03955
gene id: 1873524:HSR6_RS03955
uniprot id: A0A1D8S3M9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1873524:HSR6 RS05700
gene id: 1873524:HSR6_RS05700
uniprot id: A0A1D8S4K9
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS07015
gene id: 1873524:HSR6_RS07015
uniprot id: A0A1J1ADK7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS10325
gene id: 1873524:HSR6_RS10325
uniprot id: A0A1J1AFA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

1873524:HSR6 RS09990
gene id: 1873524:HSR6_RS09990
uniprot id: A0A1J1AFP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1873524:HSR6 RS09200
gene id: 1873524:HSR6_RS09200
uniprot id: A0A1J1ADQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

1873524:HSR6 RS04675
gene id: 1873524:HSR6_RS04675
uniprot id: A0A1D8S447
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1873524:HSR6 RS05570
gene id: 1873524:HSR6_RS05570
uniprot id: A0A1J1ADB9
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS05125
gene id: 1873524:HSR6_RS05125
uniprot id: A0A1J1ABH3
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS10710
gene id: 1873524:HSR6_RS10710
uniprot id: A0A1J1AG29
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS04140
gene id: 1873524:HSR6_RS04140
uniprot id: A0A1J1ABX9
names: Subcellular Location Annotation
messages: Cytoplasm

1873524:HSR6 RS01830
gene id: 1873524:HSR6_RS01830
uniprot id: A0A1J1A9N5
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1873524:HSR6 RS00250
gene id: 1873524:HSR6_RS00250
uniprot id: A0A1J1AAD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1873524:HSR6 RS09670
gene id: 1873524:HSR6_RS09670
uniprot id: A0A1D8S6N6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

1873524:HSR6 RS10450
gene id: 1873524:HSR6_RS10450
uniprot id: A0A1J1AFB4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1873524:HSR6 RS08005
gene id: 1873524:HSR6_RS08005
uniprot id: A0A1J1AD16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

1873524:HSR6 RS02285
gene id: 1873524:HSR6_RS02285
uniprot id: A0A1D8S2U3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
messages: Tetramer of two components I and two components II.

1873524:HSR6 RS02870
gene id: 1873524:HSR6_RS02870
uniprot id: A0A1D8S356
names: Similarity
messages: Belongs to the FUN14 family.

1873524:HSR6 RS07575
gene id: 1873524:HSR6_RS07575
uniprot id: A0A1D8S5J1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1873524:HSR6 RS09445
gene id: 1873524:HSR6_RS09445
uniprot id: A0A1D8S6J5
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

1873524:HSR6 RS01635
gene id: 1873524:HSR6_RS01635
uniprot id: A0A1J1AA75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1873524:HSR6 RS01695
gene id: 1873524:HSR6_RS01695
uniprot id: A0A1J1AB62
names: Function
messages: Part of a potassium transport system.

1873524:HSR6 RS01940
gene id: 1873524:HSR6_RS01940
uniprot id: A0A1D8S2L8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS06005
gene id: 1873524:HSR6_RS06005
uniprot id: A0A1D8S4S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1873524:HSR6 RS04215
gene id: 1873524:HSR6_RS04215
uniprot id: A0A1J1ABZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1873524:HSR6 RS06780
gene id: 1873524:HSR6_RS06780
uniprot id: A0A1J1ADF8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1873524:HSR6 RS01405
gene id: 1873524:HSR6_RS01405
uniprot id: A0A1J1AB11
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Tetramer of two components I and two components II.

1873524:HSR6 RS08050
gene id: 1873524:HSR6_RS08050
uniprot id: A0A1J1AD24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the halobacterial S-layer protein family.
messages: Cell membrane
messages: Membrane
messages: S-layer

1873524:HSR6 RS05165
gene id: 1873524:HSR6_RS05165
uniprot id: A0A1D8S4A2
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

1873524:HSR6 RS03890
gene id: 1873524:HSR6_RS03890
uniprot id: A0A1D8S3M0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1873524:HSR6 RS00055
gene id: 1873524:HSR6_RS00055
uniprot id: A0A1D8S1H6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1873524:HSR6 RS03810
gene id: 1873524:HSR6_RS03810
uniprot id: A0A1D8S3K0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

1873524:HSR6 RS06035
gene id: 1873524:HSR6_RS06035
uniprot id: A0A1D8S4R7
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS07580
gene id: 1873524:HSR6_RS07580
uniprot id: A0A1D8S5J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

1873524:HSR6 RS00165
gene id: 1873524:HSR6_RS00165
uniprot id: A0A1J1A8R4
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1873524:HSR6 RS06050
gene id: 1873524:HSR6_RS06050
uniprot id: A0A1D8S4S4
names: Similarity
messages: Belongs to the complex I subunit 3 family.

1873524:HSR6 RS05255
gene id: 1873524:HSR6_RS05255
uniprot id: A0A1J1ABI9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS07925
gene id: 1873524:HSR6_RS07925
uniprot id: A0A1J1ACZ9
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

1873524:HSR6 RS09545
gene id: 1873524:HSR6_RS09545
uniprot id: A0A1J1AFI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

1873524:HSR6 RS02140
gene id: 1873524:HSR6_RS02140
uniprot id: A0A1J1AAT9
names: Similarity
messages: Belongs to the CobT family.

1873524:HSR6 RS03715
gene id: 1873524:HSR6_RS03715
uniprot id: A0A1J1AC99
names: Similarity
messages: Belongs to the peptidase M24B family.

1873524:HSR6 RS09560
gene id: 1873524:HSR6_RS09560
uniprot id: A0A1J1ADW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1873524:HSR6 RS06830
gene id: 1873524:HSR6_RS06830
uniprot id: A0A1D8S539
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

1873524:HSR6 RS02375
gene id: 1873524:HSR6_RS02375
uniprot id: A0A1J1AAW6
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

1873524:HSR6 RS05550
gene id: 1873524:HSR6_RS05550
uniprot id: A0A1J1ACF5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1873524:HSR6 RS03310
gene id: 1873524:HSR6_RS03310
uniprot id: A0A1D8S3B6
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS09090
gene id: 1873524:HSR6_RS09090
uniprot id: A0A1J1ADN4
names: Similarity
messages: Belongs to the GcvT family.

1873524:HSR6 RS05070
gene id: 1873524:HSR6_RS05070
uniprot id: A0A1J1ACI6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1873524:HSR6 RS00380
gene id: 1873524:HSR6_RS00380
uniprot id: A0A1J1A9U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1873524:HSR6 RS08020
gene id: 1873524:HSR6_RS08020
uniprot id: A0A1D8S5S6
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

1873524:HSR6 RS01255
gene id: 1873524:HSR6_RS01255
uniprot id: A0A1J1AAC2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1873524:HSR6 RS06525
gene id: 1873524:HSR6_RS06525
uniprot id: A0A1J1AC78
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS08865
gene id: 1873524:HSR6_RS08865
uniprot id: A0A1J1ADH7
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1873524:HSR6 RS07140
gene id: 1873524:HSR6_RS07140
uniprot id: A0A1J1AE66
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS00150
gene id: 1873524:HSR6_RS00150
uniprot id: A0A1J1A9P9
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

1873524:HSR6 RS00235
gene id: 1873524:HSR6_RS00235
uniprot id: A0A1D8S1M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1873524:HSR6 RS03680
gene id: 1873524:HSR6_RS03680
uniprot id: A0A1J1ABN8
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS01715
gene id: 1873524:HSR6_RS01715
uniprot id: A0A1J1AA92
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1873524:HSR6 RS11245
gene id: 1873524:HSR6_RS11245
uniprot id: A0A1J1AFF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

1873524:HSR6 RS03880
gene id: 1873524:HSR6_RS03880
uniprot id: A0A1J1ABS7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

1873524:HSR6 RS09910
gene id: 1873524:HSR6_RS09910
uniprot id: A0A1D8S6T3
names: Similarity
messages: Belongs to the AAA ATPase family.

1873524:HSR6 RS00905
gene id: 1873524:HSR6_RS00905
uniprot id: A0A1J1AA65
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1873524:HSR6 RS02320
gene id: 1873524:HSR6_RS02320
uniprot id: A0A1D8S2W8
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS02405
gene id: 1873524:HSR6_RS02405
uniprot id: A0A1D8S2W5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1873524:HSR6 RS09095
gene id: 1873524:HSR6_RS09095
uniprot id: A0A1J1AEB1
names: Similarity
messages: Belongs to the AOR/FOR family.

1873524:HSR6 RS11325
gene id: 1873524:HSR6_RS11325
uniprot id: A0A1J1ADQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

1873524:HSR6 RS05410
gene id: 1873524:HSR6_RS05410
uniprot id: A0A1J1ABM6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS08405
gene id: 1873524:HSR6_RS08405
uniprot id: A0A1D8S609
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1873524:HSR6 RS02085
gene id: 1873524:HSR6_RS02085
uniprot id: A0A1D8S2P8
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

1873524:HSR6 RS07960
gene id: 1873524:HSR6_RS07960
uniprot id: A0A1D8S5Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1873524:HSR6 RS09625
gene id: 1873524:HSR6_RS09625
uniprot id: A0A1D8S6M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1873524:HSR6 RS03035
gene id: 1873524:HSR6_RS03035
uniprot id: A0A1J1AAA6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1873524:HSR6 RS01075
gene id: 1873524:HSR6_RS01075
uniprot id: A0A1D8S259
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS00770
gene id: 1873524:HSR6_RS00770
uniprot id: A0A1D8S1Z5
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS02195
gene id: 1873524:HSR6_RS02195
uniprot id: A0A1D8S2S4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1873524:HSR6 RS06065
gene id: 1873524:HSR6_RS06065
uniprot id: A0A1J1AD14
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS07695
gene id: 1873524:HSR6_RS07695
uniprot id: A0A1D8S5L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1873524:HSR6 RS07935
gene id: 1873524:HSR6_RS07935
uniprot id: A0A1D8S5R9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

1873524:HSR6 RS04980
gene id: 1873524:HSR6_RS04980
uniprot id: A0A1J1AC53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1873524:HSR6 RS09955
gene id: 1873524:HSR6_RS09955
uniprot id: A0A1D8S6U6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

1873524:HSR6 RS07500
gene id: 1873524:HSR6_RS07500
uniprot id: A0A1J1AEE1
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS09550
gene id: 1873524:HSR6_RS09550
uniprot id: A0A1D8S6L6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

1873524:HSR6 RS07390
gene id: 1873524:HSR6_RS07390
uniprot id: A0A1J1ADR6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

1873524:HSR6 RS03490
gene id: 1873524:HSR6_RS03490
uniprot id: A0A1J1ABA9
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1873524:HSR6 RS01965
gene id: 1873524:HSR6_RS01965
uniprot id: A0A1D8S2M5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1873524:HSR6 RS02875
gene id: 1873524:HSR6_RS02875
uniprot id: A0A1D8S360
names: Similarity
messages: Belongs to the SDO1/SBDS family.

1873524:HSR6 RS02280
gene id: 1873524:HSR6_RS02280
uniprot id: A0A1J1A9W1
names: Similarity
messages: Belongs to the TrpF family.

1873524:HSR6 RS00890
gene id: 1873524:HSR6_RS00890
uniprot id: A0A1D8S1Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homodimer.

1873524:HSR6 RS00230
gene id: 1873524:HSR6_RS00230
uniprot id: A0A1J1A8S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS09320
gene id: 1873524:HSR6_RS09320
uniprot id: A0A1D8S6K2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1873524:HSR6 RS05300
gene id: 1873524:HSR6_RS05300
uniprot id: A0A1J1ACB1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS00355
gene id: 1873524:HSR6_RS00355
uniprot id: A0A1J1A8V4
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1873524:HSR6 RS10655
gene id: 1873524:HSR6_RS10655
uniprot id: A0A1J1AEJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1873524:HSR6 RS05210
gene id: 1873524:HSR6_RS05210
uniprot id: A0A1D8S4B2
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

1873524:HSR6 RS11330
gene id: 1873524:HSR6_RS11330
uniprot id: A0A1D8S6H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

1873524:HSR6 RS00575
gene id: 1873524:HSR6_RS00575
uniprot id: A0A1J1A9V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1873524:HSR6 RS09945
gene id: 1873524:HSR6_RS09945
uniprot id: A0A1D8S6U7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

1873524:HSR6 RS07840
gene id: 1873524:HSR6_RS07840
uniprot id: A0A1D8S5P4
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS05555
gene id: 1873524:HSR6_RS05555
uniprot id: A0A1J1ABQ7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

1873524:HSR6 RS09570
gene id: 1873524:HSR6_RS09570
uniprot id: A0A1D8S6L4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1873524:HSR6 RS01340
gene id: 1873524:HSR6_RS01340
uniprot id: A0A1J1A9E7
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1873524:HSR6 RS05425
gene id: 1873524:HSR6_RS05425
uniprot id: A0A1J1ACD4
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1873524:HSR6 RS05270
gene id: 1873524:HSR6_RS05270
uniprot id: A0A1D8S4C3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS05535
gene id: 1873524:HSR6_RS05535
uniprot id: A0A1J1ABQ3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

1873524:HSR6 RS07805
gene id: 1873524:HSR6_RS07805
uniprot id: A0A1D8S5N5
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1873524:HSR6 RS08715
gene id: 1873524:HSR6_RS08715
uniprot id: A0A1J1AE53
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

1873524:HSR6 RS09715
gene id: 1873524:HSR6_RS09715
uniprot id: A0A1D8S6P9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

1873524:HSR6 RS02680
gene id: 1873524:HSR6_RS02680
uniprot id: A0A1J1AA40
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1873524:HSR6 RS06665
gene id: 1873524:HSR6_RS06665
uniprot id: A0A1J1ADX0
names: Similarity
messages: Belongs to the PEPCase type 1 family.

1873524:HSR6 RS00495
gene id: 1873524:HSR6_RS00495
uniprot id: A0A1D8S1V2
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1873524:HSR6 RS00700
gene id: 1873524:HSR6_RS00700
uniprot id: A0A1J1AA18
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

1873524:HSR6 RS01455
gene id: 1873524:HSR6_RS01455
uniprot id: A0A1J1AAG1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1873524:HSR6 RS02050
gene id: 1873524:HSR6_RS02050
uniprot id: A0A1J1AAQ5
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS01375
gene id: 1873524:HSR6_RS01375
uniprot id: A0A1D8S2B7
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1873524:HSR6 RS01575
gene id: 1873524:HSR6_RS01575
uniprot id: A0A1D8S2E7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1873524:HSR6 RS03395
gene id: 1873524:HSR6_RS03395
uniprot id: A0A1D8S3C5
names: Similarity
messages: Belongs to the UPF0179 family.

1873524:HSR6 RS10525
gene id: 1873524:HSR6_RS10525
uniprot id: A0A1D8S781
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS01460
gene id: 1873524:HSR6_RS01460
uniprot id: A0A1D8S2B9
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

1873524:HSR6 RS10560
gene id: 1873524:HSR6_RS10560
uniprot id: A0A1J1AFE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1873524:HSR6 RS09650
gene id: 1873524:HSR6_RS09650
uniprot id: A0A1J1ADY6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

1873524:HSR6 RS00590
gene id: 1873524:HSR6_RS00590
uniprot id: A0A1D8S1V5
names: Similarity
messages: Belongs to the PDCD5 family.

1873524:HSR6 RS03585
gene id: 1873524:HSR6_RS03585
uniprot id: A0A1J1ABL1
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1873524:HSR6 RS00375
gene id: 1873524:HSR6_RS00375
uniprot id: A0A1J1A8V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1873524:HSR6 RS08730
gene id: 1873524:HSR6_RS08730
uniprot id: A0A1J1AEK7
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

1873524:HSR6 RS05225
gene id: 1873524:HSR6_RS05225
uniprot id: A0A1D8S4B9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

1873524:HSR6 RS10330
gene id: 1873524:HSR6_RS10330
uniprot id: A0A1D8S728
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1873524:HSR6 RS01100
gene id: 1873524:HSR6_RS01100
uniprot id: A0A1D8S270
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS04010
gene id: 1873524:HSR6_RS04010
uniprot id: A0A1J1ABV5
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1873524:HSR6 RS00690
gene id: 1873524:HSR6_RS00690
uniprot id: A0A1D8S1X5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

1873524:HSR6 RS02590
gene id: 1873524:HSR6_RS02590
uniprot id: A0A1D8S303
names: Similarity
messages: Belongs to the UPF0175 family.

1873524:HSR6 RS03910
gene id: 1873524:HSR6_RS03910
uniprot id: A0A1D8S3M4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1873524:HSR6 RS09205
gene id: 1873524:HSR6_RS09205
uniprot id: A0A1D8S6E9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Homodimer.

1873524:HSR6 RS06905
gene id: 1873524:HSR6_RS06905
uniprot id: A0A1D8S551
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1873524:HSR6 RS08125
gene id: 1873524:HSR6_RS08125
uniprot id: A0A1D8S5V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1873524:HSR6 RS05960
gene id: 1873524:HSR6_RS05960
uniprot id: A0A1D8S4R2
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

1873524:HSR6 RS00025
gene id: 1873524:HSR6_RS00025
uniprot id: A0A1J1A8P0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1873524:HSR6 RS07825
gene id: 1873524:HSR6_RS07825
uniprot id: A0A1J1ACX0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1873524:HSR6 RS00710
gene id: 1873524:HSR6_RS00710
uniprot id: A0A1J1A9Q1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

1873524:HSR6 RS09140
gene id: 1873524:HSR6_RS09140
uniprot id: A0A1J1ADP5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1873524:HSR6 RS02710
gene id: 1873524:HSR6_RS02710
uniprot id: A0A1J1AA42
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

1873524:HSR6 RS01335
gene id: 1873524:HSR6_RS01335
uniprot id: A0A1D8S292
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS01520
gene id: 1873524:HSR6_RS01520
uniprot id: A0A1J1AAF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
messages: Cytoplasm

1873524:HSR6 RS07985
gene id: 1873524:HSR6_RS07985
uniprot id: A0A1D8S5S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1873524:HSR6 RS06505
gene id: 1873524:HSR6_RS06505
uniprot id: A0A1J1AC72
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS00205
gene id: 1873524:HSR6_RS00205
uniprot id: A0A1J1A9V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1873524:HSR6 RS05340
gene id: 1873524:HSR6_RS05340
uniprot id: A0A1J1ACC0
names: Similarity
messages: Belongs to the UPF0107 family.

1873524:HSR6 RS02705
gene id: 1873524:HSR6_RS02705
uniprot id: A0A1J1ABQ5
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

1873524:HSR6 RS10590
gene id: 1873524:HSR6_RS10590
uniprot id: A0A1J1AG07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

1873524:HSR6 RS00585
gene id: 1873524:HSR6_RS00585
uniprot id: A0A1J1A904
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS09825
gene id: 1873524:HSR6_RS09825
uniprot id: A0A1J1AF57
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS09130
gene id: 1873524:HSR6_RS09130
uniprot id: A0A1J1ADP1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

1873524:HSR6 RS00670
gene id: 1873524:HSR6_RS00670
uniprot id: A0A1D8S1V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1873524:HSR6 RS03965
gene id: 1873524:HSR6_RS03965
uniprot id: A0A1D8S3N0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1873524:HSR6 RS00085
gene id: 1873524:HSR6_RS00085
uniprot id: A0A1D8S1J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS10310
gene id: 1873524:HSR6_RS10310
uniprot id: A0A1D8S710
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

1873524:HSR6 RS05690
gene id: 1873524:HSR6_RS05690
uniprot id: A0A1D8S4K7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS06675
gene id: 1873524:HSR6_RS06675
uniprot id: A0A1D8S508
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1873524:HSR6 RS03330
gene id: 1873524:HSR6_RS03330
uniprot id: A0A1J1AAG5
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

1873524:HSR6 RS07565
gene id: 1873524:HSR6_RS07565
uniprot id: A0A1J1ACT6
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

1873524:HSR6 RS05485
gene id: 1873524:HSR6_RS05485
uniprot id: A0A1D8S4H2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1873524:HSR6 RS08590
gene id: 1873524:HSR6_RS08590
uniprot id: A0A1J1AE28
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1873524:HSR6 RS03905
gene id: 1873524:HSR6_RS03905
uniprot id: A0A1J1ABU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

1873524:HSR6 RS02735
gene id: 1873524:HSR6_RS02735
uniprot id: A0A1J1ABA0
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1873524:HSR6 RS05830
gene id: 1873524:HSR6_RS05830
uniprot id: A0A1J1ABV2
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS05640
gene id: 1873524:HSR6_RS05640
uniprot id: A0A1D8S4J5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

1873524:HSR6 RS10170
gene id: 1873524:HSR6_RS10170
uniprot id: A0A1J1AF82
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

1873524:HSR6 RS08045
gene id: 1873524:HSR6_RS08045
uniprot id: A0A1J1AE45
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS02885
gene id: 1873524:HSR6_RS02885
uniprot id: A0A1J1AAY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1873524:HSR6 RS03925
gene id: 1873524:HSR6_RS03925
uniprot id: A0A1D8S3M2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1873524:HSR6 RS04570
gene id: 1873524:HSR6_RS04570
uniprot id: A0A1J1AB67
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1873524:HSR6 RS06885
gene id: 1873524:HSR6_RS06885
uniprot id: A0A1J1ADM2
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

1873524:HSR6 RS05345
gene id: 1873524:HSR6_RS05345
uniprot id: A0A1J1ABL5
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS02170
gene id: 1873524:HSR6_RS02170
uniprot id: A0A1J1ABF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

1873524:HSR6 RS00695
gene id: 1873524:HSR6_RS00695
uniprot id: A0A1J1A928
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1873524:HSR6 RS03580
gene id: 1873524:HSR6_RS03580
uniprot id: A0A1J1ABR3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

1873524:HSR6 RS07075
gene id: 1873524:HSR6_RS07075
uniprot id: A0A1J1ACH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1873524:HSR6 RS08585
gene id: 1873524:HSR6_RS08585
uniprot id: A0A1D8S625
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

1873524:HSR6 RS04560
gene id: 1873524:HSR6_RS04560
uniprot id: A0A1J1AB64
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

1873524:HSR6 RS03270
gene id: 1873524:HSR6_RS03270
uniprot id: A0A1D8S393
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS08300
gene id: 1873524:HSR6_RS08300
uniprot id: A0A1D8S5Y8
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

1873524:HSR6 RS07735
gene id: 1873524:HSR6_RS07735
uniprot id: A0A1J1AEI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

1873524:HSR6 RS06000
gene id: 1873524:HSR6_RS06000
uniprot id: A0A1D8S4R5
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS10165
gene id: 1873524:HSR6_RS10165
uniprot id: A0A1D8S6Y3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

1873524:HSR6 RS01875
gene id: 1873524:HSR6_RS01875
uniprot id: A0A1J1AAC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1873524:HSR6 RS05280
gene id: 1873524:HSR6_RS05280
uniprot id: A0A1D8S4D8
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS05040
gene id: 1873524:HSR6_RS05040
uniprot id: A0A1J1ABF8
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

1873524:HSR6 RS07585
gene id: 1873524:HSR6_RS07585
uniprot id: A0A1D8S5J5
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

1873524:HSR6 RS00750
gene id: 1873524:HSR6_RS00750
uniprot id: A0A1D8S1Y8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

1873524:HSR6 RS10240
gene id: 1873524:HSR6_RS10240
uniprot id: A0A1J1AEA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

1873524:HSR6 RS03870
gene id: 1873524:HSR6_RS03870
uniprot id: A0A1D8S3L8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

1873524:HSR6 RS04170
gene id: 1873524:HSR6_RS04170
uniprot id: A0A1D8S3T3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1873524:HSR6 RS07760
gene id: 1873524:HSR6_RS07760
uniprot id: A0A1D8S5N2
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS01890
gene id: 1873524:HSR6_RS01890
uniprot id: A0A1J1AAM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

1873524:HSR6 RS07780
gene id: 1873524:HSR6_RS07780
uniprot id: A0A1D8S5N3
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

1873524:HSR6 RS03885
gene id: 1873524:HSR6_RS03885
uniprot id: A0A1D8S3P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

1873524:HSR6 RS00815
gene id: 1873524:HSR6_RS00815
uniprot id: A0A1D8S1Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1873524:HSR6 RS10020
gene id: 1873524:HSR6_RS10020
uniprot id: A0A1D8S6W8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1873524:HSR6 RS07545
gene id: 1873524:HSR6_RS07545
uniprot id: A0A1D8S5J9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

1873524:HSR6 RS10715
gene id: 1873524:HSR6_RS10715
uniprot id: A0A1J1AEK4
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

1873524:HSR6 RS02155
gene id: 1873524:HSR6_RS02155
uniprot id: A0A1D8S2U2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1873524:HSR6 RS06040
gene id: 1873524:HSR6_RS06040
uniprot id: A0A1J1AC01
names: Similarity
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

1873524:HSR6 RS01090
gene id: 1873524:HSR6_RS01090
uniprot id: A0A1D8S243
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS02880
gene id: 1873524:HSR6_RS02880
uniprot id: A0A1J1AA81
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1873524:HSR6 RS04995
gene id: 1873524:HSR6_RS04995
uniprot id: A0A1J1ACH3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

1873524:HSR6 RS03300
gene id: 1873524:HSR6_RS03300
uniprot id: A0A1J1ABF3
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS07910
gene id: 1873524:HSR6_RS07910
uniprot id: A0A1J1AEL3
names: Similarity
messages: Belongs to the HerA family.

1873524:HSR6 RS00170
gene id: 1873524:HSR6_RS00170
uniprot id: A0A1J1A9U3
names: Similarity
messages: Belongs to the glutaredoxin family.

1873524:HSR6 RS04690
gene id: 1873524:HSR6_RS04690
uniprot id: A0A1J1AB89
names: Subcellular Location Annotation
messages: Membrane

1873524:HSR6 RS05390
gene id: 1873524:HSR6_RS05390
uniprot id: A0A1J1ABL9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

1873524:HSR6 RS01580
gene id: 1873524:HSR6_RS01580
uniprot id: A0A1D8S2F2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1873524:HSR6 RS03420
gene id: 1873524:HSR6_RS03420
uniprot id: A0A1J1ABN0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1873524:HSR6 RS03795
gene id: 1873524:HSR6_RS03795
uniprot id: A0A1D8S3K9
names: Subcellular Location Annotation
messages: Cytoplasm

1873524:HSR6 RS10315
gene id: 1873524:HSR6_RS10315
uniprot id: A0A1J1AFU3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1873524:HSR6 RS02940
gene id: 1873524:HSR6_RS02940
uniprot id: A0A1J1AB79
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

1873524:HSR6 RS00910
gene id: 1873524:HSR6_RS00910
uniprot id: A0A1J1A974
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

1873524:HSR6 RS10235
gene id: 1873524:HSR6_RS10235
uniprot id: A0A1J1AFT3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

1873524:HSR6 RS05865
gene id: 1873524:HSR6_RS05865
uniprot id: A0A1D8S4P6
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

1873524:HSR6 RS05745
gene id: 1873524:HSR6_RS05745
uniprot id: A0A1D8S4M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1873524:HSR6 RS10400
gene id: 1873524:HSR6_RS10400
uniprot id: A0A1J1AFV2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.