186497:PFDSM3638 RS07240
gene id: 186497:PFDSM3638_RS07240
uniprot id: A0A5C0XQP9
uniprot id: E7FHA4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS08485
gene id: 186497:PFDSM3638_RS08485
uniprot id: A0A5C0XRC7
uniprot id: Q8U0C9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S8 family.
messages: Monomer.
messages: Serine protease with a broad substrate specificity.

186497:PFDSM3638 RS08230
gene id: 186497:PFDSM3638_RS08230
uniprot id: A0A5C0XRN5
uniprot id: Q8U0G6
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

186497:PFDSM3638 RS01200
gene id: 186497:PFDSM3638_RS01200
uniprot id: A0A5C0XMQ3
uniprot id: Q8U443
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS00325
gene id: 186497:PFDSM3638_RS00325
uniprot id: A0A5C0XLR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.
messages: Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
messages: Cytoplasm

186497:PFDSM3638 RS06250
gene id: 186497:PFDSM3638_RS06250
uniprot id: A0A5C0XQC4
uniprot id: Q8U1G1
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS03285
gene id: 186497:PFDSM3638_RS03285
uniprot id: A0A5C0XMQ0
uniprot id: Q8U319
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Cytoplasm
messages: Homotetramer.

186497:PFDSM3638 RS09520
gene id: 186497:PFDSM3638_RS09520
uniprot id: A0A5C0XUC6
uniprot id: Q8TZU7
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

186497:PFDSM3638 RS06415
gene id: 186497:PFDSM3638_RS06415
uniprot id: A0A5C0XQA7
uniprot id: P82385
names: Function
names: Similarity
names: Subunit
messages: Belongs to the desulfoferrodoxin family.
messages: Homotetramer.
messages: Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide.

186497:PFDSM3638 RS10075
gene id: 186497:PFDSM3638_RS10075
uniprot id: A0A5C0XRT3
uniprot id: Q8TZJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

186497:PFDSM3638 RS00340
gene id: 186497:PFDSM3638_RS00340
uniprot id: A0A5C0XN35
uniprot id: Q8U4K3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Probably responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (WtpC), two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).

186497:PFDSM3638 RS07760
gene id: 186497:PFDSM3638_RS07760
uniprot id: A0A5C0XQZ0
uniprot id: Q8U0Q0
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

186497:PFDSM3638 RS10160
gene id: 186497:PFDSM3638_RS10160
uniprot id: A0A5C0XS44
uniprot id: Q8TZI4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS02645
gene id: 186497:PFDSM3638_RS02645
uniprot id: A0A5C0XNP1
uniprot id: Q8U3D9
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS06075
gene id: 186497:PFDSM3638_RS06075
uniprot id: A0A5C0XSF7
uniprot id: Q8U1J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

186497:PFDSM3638 RS04640
gene id: 186497:PFDSM3638_RS04640
uniprot id: A0A5C0XNP5
uniprot id: Q8U2B7
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS01290
gene id: 186497:PFDSM3638_RS01290
uniprot id: A0A5C0XMS5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

186497:PFDSM3638 RS07545
gene id: 186497:PFDSM3638_RS07545
uniprot id: A0A5C0XQ38
uniprot id: Q8U0T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0252 family.
messages: Membrane

186497:PFDSM3638 RS02955
gene id: 186497:PFDSM3638_RS02955
uniprot id: A0A5C0XR22
uniprot id: Q8U383
names: Similarity
messages: Belongs to the phosphohexose mutase family.

186497:PFDSM3638 RS08730
gene id: 186497:PFDSM3638_RS08730
uniprot id: A0A5C0XTX9
uniprot id: Q8U082
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

186497:PFDSM3638 RS00830
gene id: 186497:PFDSM3638_RS00830
uniprot id: A0A5C0XQ18
uniprot id: Q8U4B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

186497:PFDSM3638 RS07840
gene id: 186497:PFDSM3638_RS07840
uniprot id: A0A5C0XR05
uniprot id: Q8U0N7
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the GTP-dependent conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm
messages: Generally, RNA 3'-terminal phosphate cyclases are ATP dependent, but P.furiosus enzyme preferentially uses GTP rather than ATP.
messages: Inhibited by GMP.

186497:PFDSM3638 RS06720
gene id: 186497:PFDSM3638_RS06720
uniprot id: P81535
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily.
messages: Binds 2 cobalt ions per subunit. Co(2+) can be replaced by Mn(2+), resulting in a 25% decrease in activity, but not by Mg(2+), Ca(2+), Fe(2+), Zn(2+), Cu(2+), or Ni(2+).
messages: Cobalt 1 is the tight-binding and cobalt 2 is the loose-binding metal center.
messages: Cytoplasm
messages: Homodimer.
messages: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position.

186497:PFDSM3638 RS09310
gene id: 186497:PFDSM3638_RS09310
uniprot id: A0A5C0XS70
uniprot id: Q8TZY1
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS05545
gene id: 186497:PFDSM3638_RS05545
uniprot id: A0A5C0XPN9
uniprot id: Q8U1V2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS08040
gene id: 186497:PFDSM3638_RS08040
uniprot id: A0A5C0XR39
names: Similarity
messages: Belongs to the HypE family.

186497:PFDSM3638 RS05675
gene id: 186497:PFDSM3638_RS05675
uniprot id: Q8U1S7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CRISPR system Cmr3 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), formerly called psiRNA (prokaryotic silencing) in this organism. Part of the Cmr ribonucleoprotein complex which has divalent cation-dependent endoribonuclease activity specific for ssRNA complementary to the crRNA (target RNA), generating 5' hydroxy- and 3' phosphate or 2'-3' cyclic phosphate termini. Cmr4 is probably the subunit that cleaves target RNA (PubMed:25280103). Cmr complex does not cleave ssDNA complementary to the crRNA. Cleavage of invading RNA is guided by the crRNA; substrate cleavage occurs a fixed distance (14 nt) from the 3' end of the crRNA. In vitro reconstitution shows Cmr1-2 and Cmr5 are not absolutely necessary for target cleavage.
messages: Cytoplasm
messages: Part of the type III-B Cmr ribonucleoprotein (RNP) complex, an elongated RNP with Cmr2 and Cmr3 as the base, with Cmr4 and Cmr5 forming a helical core along the mature crRNA (39 or 45 nt in length), while the complex is capped by Cmr6 and Cmr1. The 5' end of the crRNA is bound to Cmr2 and Cmr3, while Cmr6 and a Cmr1 subunit (Cmr1-1 or Cmr1-2) cap the 3' end of the crRNA. The target RNA lies antiparallel to the crRNA, with its 5' end near Cmr1 and Cmr6 and its 3' end near Cmr2 and Cmr3; major target cleavage occurs nears the junction of Cmr1/Cmr6 and Cmr4/Cmr, with minor cleavage occurring at 6 nt intervals which coincide with the proposed spacing of Cmr4 subunits (PubMed:24119404, PubMed:25280103). Forms a 1:1 complex with Cmr2 (PubMed:23583914, PubMed:23395183, PubMed:23583914). Interacts with Cmr4 (PubMed:25280103). The complex non-specifically binds ss-target RNA and crRNA (PubMed:23583914).

186497:PFDSM3638 RS02250
gene id: 186497:PFDSM3638_RS02250
uniprot id: A0A5C0XP25
uniprot id: Q8U3L4
names: Similarity
messages: Belongs to the UPF0216 family.

186497:PFDSM3638 RS06730
gene id: 186497:PFDSM3638_RS06730
uniprot id: A0A5C0XW02
uniprot id: Q8U182
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Shows also activity toward a broad range of substrates, such as intron containing pre-tRNAs, 5' extended precursors and non-RNA substrates.

186497:PFDSM3638 RS05110
gene id: 186497:PFDSM3638_RS05110
uniprot id: A0A5C0XQ75
uniprot id: Q8U238
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS05785
gene id: 186497:PFDSM3638_RS05785
uniprot id: A0A5C0XQI4
uniprot id: Q8U1Q5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS02435
gene id: 186497:PFDSM3638_RS02435
uniprot id: A0A5C0XNM2
uniprot id: Q8U3H8
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS6 family.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS05010
gene id: 186497:PFDSM3638_RS05010
uniprot id: A0A5C0XNC3
uniprot id: Q8U259
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate. To a lesser extent, also catalyzes the oxidation of L-serine, D-threonine, butan-2,3-diol, butan-1,2-diol, and propan-1,2-diol and cannot oxidize other L-amino acids. Cannot utilize NADP(H) instead of NAD(H).
messages: Cytoplasm
messages: Homotetramer.

186497:PFDSM3638 RS06505
gene id: 186497:PFDSM3638_RS06505
uniprot id: A0A5C0XQC7
uniprot id: O73944
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer made of two disulfide-linked dimers.
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

186497:PFDSM3638 RS06045
gene id: 186497:PFDSM3638_RS06045
uniprot id: A0A5C0XQM8
uniprot id: Q8U1K2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

186497:PFDSM3638 RS02360
gene id: 186497:PFDSM3638_RS02360
uniprot id: A0A5C0XMD2
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

186497:PFDSM3638 RS10280
gene id: 186497:PFDSM3638_RS10280
uniprot id: A0A5C0XQV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

186497:PFDSM3638 RS05015
gene id: 186497:PFDSM3638_RS05015
uniprot id: A0A5C0XNU5
uniprot id: Q8U258
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS05995
gene id: 186497:PFDSM3638_RS05995
uniprot id: A0A5C0XQL9
uniprot id: Q8U1L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.
messages: Homododecamer. The 12 identical subunits form a holow sphere unto which the mineral iron core of up to 300 Fe(3+) can be deposited.
messages: Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). It efficiently oxidizes Fe(2+) in the presence of hydrogen peroxide and stores it.
messages: Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.
messages: nucleoid

186497:PFDSM3638 RS07755
gene id: 186497:PFDSM3638_RS07755
uniprot id: A0A5C0XSD6
uniprot id: Q8U0Q1
names: Similarity
messages: Belongs to the band 7/mec-2 family.

186497:PFDSM3638 RS08320
gene id: 186497:PFDSM3638_RS08320
uniprot id: A0A5C0XQE5
uniprot id: Q8U0E9
names: Similarity
messages: Belongs to the enolase family.

186497:PFDSM3638 RS03080
gene id: 186497:PFDSM3638_RS03080
uniprot id: A0A5C0XQ29
uniprot id: Q8U359
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

186497:PFDSM3638 RS05615
gene id: 186497:PFDSM3638_RS05615
uniprot id: A0A5C0XQ16
uniprot id: Q8U1T9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS07775
gene id: 186497:PFDSM3638_RS07775
uniprot id: A0A5C0XSW9
uniprot id: Q8U0P7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS10190
gene id: 186497:PFDSM3638_RS10190
uniprot id: Q8TZH9
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the inositol monophosphatase superfamily. FBPase class 4 family.
messages: Catalyzes the conversion of D-fructose 1,6-bisphosphate to D-fructose 6-phosphate. In vitro, has also weak activity with inositol-1-phosphate, glucose-1-phosphate and glycerol-2-phosphate.
messages: Homodimer.
messages: Inhibited by Li(+), ADP, ATP and glucose-6-phosphate.

186497:PFDSM3638 RS08450
gene id: 186497:PFDSM3638_RS08450
uniprot id: A0A5C0XRR9
uniprot id: P58853
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

186497:PFDSM3638 RS08575
gene id: 186497:PFDSM3638_RS08575
uniprot id: A0A5C0XTV2
uniprot id: Q8U0B3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Binds 2 divalent metal cations per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

186497:PFDSM3638 RS00850
gene id: 186497:PFDSM3638_RS00850
uniprot id: A0A5C0XNW0
uniprot id: Q8U4A7
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

186497:PFDSM3638 RS01805
gene id: 186497:PFDSM3638_RS01805
uniprot id: A0A5C0XMF3
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS08610
gene id: 186497:PFDSM3638_RS08610
uniprot id: A0A5C0XWZ0
uniprot id: Q8U0A6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

186497:PFDSM3638 RS09435
gene id: 186497:PFDSM3638_RS09435
uniprot id: A0A5C0XRH4
uniprot id: Q8TZV8
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

186497:PFDSM3638 RS00865
gene id: 186497:PFDSM3638_RS00865
uniprot id: A0A5C0XT43
uniprot id: Q8U4A4
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

186497:PFDSM3638 RS02505
gene id: 186497:PFDSM3638_RS02505
uniprot id: A0A5C0XQV1
uniprot id: Q8TH18
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

186497:PFDSM3638 RS04370
gene id: 186497:PFDSM3638_RS04370
uniprot id: A0A5C0XUT6
uniprot id: Q8U2G9
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

186497:PFDSM3638 RS07015
gene id: 186497:PFDSM3638_RS07015
uniprot id: A0A5C0XQK7
uniprot id: Q8U133
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

186497:PFDSM3638 RS02760
gene id: 186497:PFDSM3638_RS02760
uniprot id: A0A5C0XU22
uniprot id: Q8U3C1
names: Similarity
messages: Belongs to the HypD family.

186497:PFDSM3638 RS05635
gene id: 186497:PFDSM3638_RS05635
uniprot id: A0A5C0XQG1
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

186497:PFDSM3638 RS10355
gene id: 186497:PFDSM3638_RS10355
uniprot id: A0A5C0XS97
uniprot id: Q8TZE6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS03855
gene id: 186497:PFDSM3638_RS03855
uniprot id: A0A5C0XP48
uniprot id: Q8U2Q8
names: Function
names: Similarity
messages: Belongs to the UPF0330 family.
messages: Possibly the antitoxin component of a toxin-antitoxin (TA) module.
messages: Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC4 (Potential).

186497:PFDSM3638 RS06685
gene id: 186497:PFDSM3638_RS06685
uniprot id: A0A5C0XQI5
uniprot id: Q8U190
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

186497:PFDSM3638 RS09085
gene id: 186497:PFDSM3638_RS09085
uniprot id: A0A5C0XRL0
uniprot id: Q8U020
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

186497:PFDSM3638 RS02370
gene id: 186497:PFDSM3638_RS02370
uniprot id: A0A5C0XPS6
uniprot id: Q8U3J1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of initiation factor 2-bound GDP for GTP.
messages: Complex of two different subunits.

186497:PFDSM3638 RS00105
gene id: 186497:PFDSM3638_RS00105
uniprot id: A0A5C0XMH0
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS01695
gene id: 186497:PFDSM3638_RS01695
uniprot id: A0A5C0XMD6
uniprot id: Q51739
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A significant amount of formaldehyde ferredoxin oxidoreductase activity has been observed.
messages: Belongs to the AOR/FOR family.
messages: Binds 1 W-bis(molybdopterin guanine dinucleotide) (W-bis-MGD) cofactor per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the oxidation of aldehydes to their corresponding carboxylic acids. May have a pyroglycolytic (saccharolytic) role.
messages: Homodimer.
messages: Inhibited by arsenite, iodoacetate and cyanide.

186497:PFDSM3638 RS06315
gene id: 186497:PFDSM3638_RS06315
uniprot id: A0A5C0XSS5
uniprot id: Q8U1E6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

186497:PFDSM3638 RS06775
gene id: 186497:PFDSM3638_RS06775
uniprot id: A0A5C0XQH2
uniprot id: Q8U173
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS09245
gene id: 186497:PFDSM3638_RS09245
uniprot id: A0A5C0XU75
uniprot id: Q8TZZ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

186497:PFDSM3638 RS09095
gene id: 186497:PFDSM3638_RS09095
uniprot id: A0A5C0XU43
uniprot id: Q8U018
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS10500
gene id: 186497:PFDSM3638_RS10500
uniprot id: A0A5C0XQZ2
uniprot id: Q8U4R3
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

186497:PFDSM3638 RS02100
gene id: 186497:PFDSM3638_RS02100
uniprot id: A0A5C0XN55
uniprot id: Q8U3N0
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

186497:PFDSM3638 RS09775
gene id: 186497:PFDSM3638_RS09775
uniprot id: A0A5C0XRY8
uniprot id: Q8TZP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

186497:PFDSM3638 RS05695
gene id: 186497:PFDSM3638_RS05695
uniprot id: A0A5C0XP65
uniprot id: Q8U1S3
names: Similarity
messages: Belongs to the NodU/CmcH family.

186497:PFDSM3638 RS01545
gene id: 186497:PFDSM3638_RS01545
uniprot id: A0A5C0XNL7
uniprot id: Q8U3Y2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.
messages: Cytoplasm
messages: Homodimer.

186497:PFDSM3638 RS05370
gene id: 186497:PFDSM3638_RS05370
uniprot id: A0A5C0XNH5
uniprot id: Q8U1Y9
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

186497:PFDSM3638 RS00240
gene id: 186497:PFDSM3638_RS00240
uniprot id: A0A5C0XNA2
uniprot id: Q8U4L8
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

186497:PFDSM3638 RS07845
gene id: 186497:PFDSM3638_RS07845
uniprot id: A0A5C0XQ74
uniprot id: Q8U0N6
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

186497:PFDSM3638 RS03455
gene id: 186497:PFDSM3638_RS03455
uniprot id: A0A5C0XTP3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

186497:PFDSM3638 RS08000
gene id: 186497:PFDSM3638_RS08000
uniprot id: A0A5C0XR50
uniprot id: Q8U0K9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

186497:PFDSM3638 RS10105
gene id: 186497:PFDSM3638_RS10105
uniprot id: A0A5C0XS37
uniprot id: Q8TZJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

186497:PFDSM3638 RS08850
gene id: 186497:PFDSM3638_RS08850
uniprot id: A0A5C0XQ19
names: Similarity
messages: Belongs to the class-I fumarase family.

186497:PFDSM3638 RS04480
gene id: 186497:PFDSM3638_RS04480
uniprot id: A0A5C0XP05
uniprot id: Q8U2E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

186497:PFDSM3638 RS06665
gene id: 186497:PFDSM3638_RS06665
uniprot id: E7FHC4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Binds 1 nickel ion per subunit.
messages: Cytoplasm
messages: Dimer of heterotetramer of alpha, beta, gamma and delta subunits. The nickel-containing alpha and delta subunits constitute the hydrogenase activity. The beta and gamma subunits (flavin-containing dimer) constitute the sulfur reductase activity.
messages: Part of a bifunctional enzyme complex that functions as a hydrogen-evolving hydrogenase with sulfur-reducing activity. May play a role in hydrogen cycling during fermentative growth. Activity exhibited with NAD in addition to NADPH. The alpha and delta subunits form the hydrogenase component that catalyzes the reduction of protons to evolve hydrogen.

186497:PFDSM3638 RS08540
gene id: 186497:PFDSM3638_RS08540
uniprot id: A0A5C0XRC2
uniprot id: Q8U0C0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

186497:PFDSM3638 RS00815
gene id: 186497:PFDSM3638_RS00815
uniprot id: A0A5C0XMX2
uniprot id: Q8U4B4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

186497:PFDSM3638 RS05225
gene id: 186497:PFDSM3638_RS05225
uniprot id: A0A5C0XR03
uniprot id: Q8U216
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

186497:PFDSM3638 RS04350
gene id: 186497:PFDSM3638_RS04350
uniprot id: A0A5C0XN32
uniprot id: Q8U2H3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

186497:PFDSM3638 RS01560
gene id: 186497:PFDSM3638_RS01560
uniprot id: A0A5C0XPD8
uniprot id: Q8U3X9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

186497:PFDSM3638 RS02640
gene id: 186497:PFDSM3638_RS02640
uniprot id: A0A5C0XU02
uniprot id: Q8U3E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

186497:PFDSM3638 RS05410
gene id: 186497:PFDSM3638_RS05410
uniprot id: A0A5C0XSB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS07010
gene id: 186497:PFDSM3638_RS07010
uniprot id: A0A5C0XS03
names: Similarity
messages: Belongs to the UPF0111 family.

186497:PFDSM3638 RS06785
gene id: 186497:PFDSM3638_RS06785
uniprot id: A0A5C0XQJ7
uniprot id: Q8U171
names: Similarity
messages: Belongs to the UDPGP type 2 family.

186497:PFDSM3638 RS02805
gene id: 186497:PFDSM3638_RS02805
uniprot id: A0A5C0XNE2
uniprot id: Q8U3B2
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS08935
gene id: 186497:PFDSM3638_RS08935
uniprot id: A0A5C0XQN2
uniprot id: Q8U046
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

186497:PFDSM3638 RS09080
gene id: 186497:PFDSM3638_RS09080
uniprot id: A0A5C0XRL1
uniprot id: Q8U021
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS02980
gene id: 186497:PFDSM3638_RS02980
uniprot id: A0A5C0XNG6
uniprot id: Q8U378
names: Similarity
messages: Belongs to the UPF0282 family.

186497:PFDSM3638 RS07080
gene id: 186497:PFDSM3638_RS07080
uniprot id: A0A5C0XQP3
uniprot id: Q8U120
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS08840
gene id: 186497:PFDSM3638_RS08840
uniprot id: A0A5C0XTZ6
uniprot id: Q8U064
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

186497:PFDSM3638 RS09325
gene id: 186497:PFDSM3638_RS09325
uniprot id: A0A5C0XT38
uniprot id: Q8TZX8
names: Similarity
messages: Belongs to the RuvB family.

186497:PFDSM3638 RS00275
gene id: 186497:PFDSM3638_RS00275
uniprot id: A0A5C0XN28
uniprot id: Q8U4L1
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

186497:PFDSM3638 RS08605
gene id: 186497:PFDSM3638_RS08605
uniprot id: A0A5C0XRD0
uniprot id: Q8U0A7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS04725
gene id: 186497:PFDSM3638_RS04725
uniprot id: A0A5C0XNU0
uniprot id: Q8U2A2
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).

186497:PFDSM3638 RS05295
gene id: 186497:PFDSM3638_RS05295
uniprot id: A0A5C0XPV9
uniprot id: Q8U203
names: Similarity
messages: Belongs to the UPF0127 family.

186497:PFDSM3638 RS01185
gene id: 186497:PFDSM3638_RS01185
uniprot id: A0A5C0XMR1
uniprot id: Q8U446
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

186497:PFDSM3638 RS09985
gene id: 186497:PFDSM3638_RS09985
uniprot id: A0A5C0XS18
uniprot id: Q8TZL3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm
messages: Homodimer.

186497:PFDSM3638 RS01055
gene id: 186497:PFDSM3638_RS01055
uniprot id: A0A5C0XLU8
uniprot id: Q8U470
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

186497:PFDSM3638 RS06280
gene id: 186497:PFDSM3638_RS06280
uniprot id: A0A5C0XPM6
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS08335
gene id: 186497:PFDSM3638_RS08335
uniprot id: A0A5C0XRQ2
uniprot id: P60292
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

186497:PFDSM3638 RS03910
gene id: 186497:PFDSM3638_RS03910
uniprot id: A0A5C0XP50
uniprot id: Q8U2Q0
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS07150
gene id: 186497:PFDSM3638_RS07150
uniprot id: A0A5C0XQM9
uniprot id: Q8U107
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS00990
gene id: 186497:PFDSM3638_RS00990
uniprot id: A0A5C0XNC9
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

186497:PFDSM3638 RS00665
gene id: 186497:PFDSM3638_RS00665
uniprot id: A0A5C0XN78
uniprot id: Q8U4E3
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

186497:PFDSM3638 RS00140
gene id: 186497:PFDSM3638_RS00140
uniprot id: A0A5C0XN87
uniprot id: P42850
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.
messages: Homooctamer.
messages: The N-terminal domain contains the ATP/Pi binding site, the central domain the pyrophosphate/phosphate carrier histidine, and the C-terminal domain the pyruvate binding site.
messages: The reaction takes place in three steps, mediated by a phosphocarrier histidine residue located on the surface of the central domain. The two first partial reactions are catalyzed at an active site located on the N-terminal domain, and the third partial reaction is catalyzed at an active site located on the C-terminal domain. For catalytic turnover, the central domain swivels from the concave surface of the N-terminal domain to that of the C-terminal domain (By similarity).

186497:PFDSM3638 RS03005
gene id: 186497:PFDSM3638_RS03005
uniprot id: A0A5C0XR30
uniprot id: Q8U374
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

186497:PFDSM3638 RS07100
gene id: 186497:PFDSM3638_RS07100
uniprot id: A0A5C0XR66
uniprot id: Q8U116
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS08690
gene id: 186497:PFDSM3638_RS08690
uniprot id: A0A5C0XPY6
uniprot id: Q8U090
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

186497:PFDSM3638 RS02540
gene id: 186497:PFDSM3638_RS02540
uniprot id: A0A5C0XNN1
uniprot id: Q8U3G0
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS08720
gene id: 186497:PFDSM3638_RS08720
uniprot id: A0A5C0XRE8
uniprot id: Q8U084
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

186497:PFDSM3638 RS09040
gene id: 186497:PFDSM3638_RS09040
uniprot id: A0A5C0XU33
uniprot id: Q8U028
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

186497:PFDSM3638 RS05800
gene id: 186497:PFDSM3638_RS05800
uniprot id: A0A5C0XRB3
uniprot id: Q8U1Q2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS03340
gene id: 186497:PFDSM3638_RS03340
uniprot id: A0A5C0XQ64
uniprot id: Q8U308
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accelerates the release of ammonia from reactive enamine/imine intermediates of the PLP-dependent threonine dehydratase (IlvA) in the low water environment of the cell. It catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia. It is required for the detoxification of reactive intermediates of IlvA due to their highly nucleophilic abilities. Involved in the isoleucine biosynthesis.
messages: Belongs to the RutC family.
messages: Cytoplasm
messages: Homotrimer.

186497:PFDSM3638 RS03820
gene id: 186497:PFDSM3638_RS03820
uniprot id: A0A5C0XND9
uniprot id: Q8U2R5
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

186497:PFDSM3638 RS05080
gene id: 186497:PFDSM3638_RS05080
uniprot id: A0A5C0XPA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

186497:PFDSM3638 RS08560
gene id: 186497:PFDSM3638_RS08560
uniprot id: A0A5C0XRC6
uniprot id: Q8U0B6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS05660
gene id: 186497:PFDSM3638_RS05660
uniprot id: A0A5C0XVG0
uniprot id: Q8U1T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CRISPR system Cmr5 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), formerly called psiRNA (prokaryotic silencing) in this organism. Part of the Cmr ribonucleoprotein complex which has divalent cation-dependent endoribonuclease activity specific for ssRNA complementary to the crRNA (target NRA), generating 5' hydroxy- and 3' phosphate or 2'-3' cyclic phosphate termini. Cmr4 is probably the subunit that cleaves target RNA (PubMed:25280103). Cmr complex does not cleave ssDNA complementary to the crRNA. Cleavage of invading RNA is guided by the crRNA; substrate cleavage occurs a fixed distance (14 nt) from the 3' end of the crRNA. In vitro reconstitution shows Cmr1-2 and Cmr5 are not absolutely necessary for target cleavage (PubMed:19945378).
messages: Cytoplasm
messages: Monomer in isolation (PubMed:23370277). Part of the type III-B Cmr ribonucleoprotein (RNP) complex, an elongated RNP with Cmr2 and Cmr3 as the base, with Cmr4 and Cmr5 forming a helical core along the mature crRNA (39 or 45 nt in length), while the complex is capped by Cmr6 and Cmr1. The 5' end of the crRNA is bound to Cmr2 and Cmr3, while Cmr6 and a Cmr1 subunit (Cmr1-1 or Cmr1-2) cap the 3' end of the crRNA. The target RNA lies antiparallel to the crRNA, with its 5' end near Cmr1 and Cmr6 and its 3' end near Cmr2 and Cmr3; major target cleavage occurs nears the junction of Cmr1/Cmr6 and Cmr4/Cmr, with minor cleavage occurring at 6 nt intervals which coincide with the proposed spacing of Cmr4 subunits (PubMed:24119404, PubMed:25280103). Interacts with Cmr4 (PubMed:23370277). Interacts with Cmr2, Cmr4 and Cmr6 (PubMed:25280103).

186497:PFDSM3638 RS08155
gene id: 186497:PFDSM3638_RS08155
uniprot id: Q8U0I0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

186497:PFDSM3638 RS08640
gene id: 186497:PFDSM3638_RS08640
uniprot id: A0A5C0XPX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

186497:PFDSM3638 RS08120
gene id: 186497:PFDSM3638_RS08120
uniprot id: A0A5C0XRM1
uniprot id: P80319
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Cytoplasm
messages: Homohexamer.

186497:PFDSM3638 RS07910
gene id: 186497:PFDSM3638_RS07910
uniprot id: A0A5C0XPL7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

186497:PFDSM3638 RS01405
gene id: 186497:PFDSM3638_RS01405
uniprot id: A0A5C0XTD6
uniprot id: Q8U406
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

186497:PFDSM3638 RS00545
gene id: 186497:PFDSM3638_RS00545
uniprot id: A0A5C0XPX1
uniprot id: Q8U4G4
names: Activity Regulation
names: Domain
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Autoregulated.
messages: Belongs to the transcriptional regulator TrmB family.
messages: Contains an N-terminal DNA-binding domain and a C-terminal sugar-binding domain.
messages: Global transcriptional repressor of the maltodextrin transport gene cluster (mdxE operon) and most likely of all genes encoding glycolytic enzymes. Acts by binding to the conserved TGM (Thermococcales-Glycolytic-Motif) sequences in their promoter region. Can also interact with non-TGM sequences.
messages: Homotetramer. Forms homooctamers in the presence of maltotriose or maltose.
messages: Repressor activity is regulated by binding of different sugars to TrmBL1. Binding of maltose and maltotriose results in derepression of the target genes. However, high sugar concentration results in formation of octamers with high affinity for DNA, which may prevent transcription of target genes.

186497:PFDSM3638 RS00480
gene id: 186497:PFDSM3638_RS00480
uniprot id: A0A5C0XMS9
uniprot id: Q8U4H7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL). Both participate in formation of the active center, but the ATP-binding site is exclusively located on the small subunit.
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

186497:PFDSM3638 RS00185
gene id: 186497:PFDSM3638_RS00185
uniprot id: A0A5C0XM12
uniprot id: Q8U4M9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

186497:PFDSM3638 RS04335
gene id: 186497:PFDSM3638_RS04335
uniprot id: A0A5C0XNP4
uniprot id: Q8U2H4
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

186497:PFDSM3638 RS07875
gene id: 186497:PFDSM3638_RS07875
uniprot id: A0A5C0XR10
uniprot id: Q8U0N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

186497:PFDSM3638 RS08315
gene id: 186497:PFDSM3638_RS08315
uniprot id: A0A5C0XR93
uniprot id: Q8U0F0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS09740
gene id: 186497:PFDSM3638_RS09740
uniprot id: A0A5C0XUG5
uniprot id: Q8TZQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

186497:PFDSM3638 RS05005
gene id: 186497:PFDSM3638_RS05005
uniprot id: A0A5C0XQ62
uniprot id: Q8U260
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

186497:PFDSM3638 RS08970
gene id: 186497:PFDSM3638_RS08970
uniprot id: A0A5C0XX51
uniprot id: Q8U039
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS08020
gene id: 186497:PFDSM3638_RS08020
uniprot id: A0A5C0XRK8
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

186497:PFDSM3638 RS07920
gene id: 186497:PFDSM3638_RS07920
uniprot id: A0A5C0XSG3
uniprot id: Q8U0M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

186497:PFDSM3638 RS07290
gene id: 186497:PFDSM3638_RS07290
uniprot id: A0A5C0XQR1
uniprot id: Q8U0Y1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS02570
gene id: 186497:PFDSM3638_RS02570
uniprot id: A0A5C0XMF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS03330
gene id: 186497:PFDSM3638_RS03330
uniprot id: A0A5C0XMQ7
uniprot id: Q8U310
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

186497:PFDSM3638 RS00410
gene id: 186497:PFDSM3638_RS00410
uniprot id: A0A5C0XMF2
uniprot id: Q8U4J0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

186497:PFDSM3638 RS09105
gene id: 186497:PFDSM3638_RS09105
uniprot id: A0A5C0XQ59
uniprot id: Q8U017
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit (PubMed:23222135). Contacts protein S4 (By similarity).
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

186497:PFDSM3638 RS04290
gene id: 186497:PFDSM3638_RS04290
uniprot id: A0A5C0XN25
uniprot id: E7FHY8
names: Similarity
messages: Belongs to the glycosyl hydrolase 12 (cellulase H) family.

186497:PFDSM3638 RS00255
gene id: 186497:PFDSM3638_RS00255
uniprot id: A0A5C0XMJ4
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS01440
gene id: 186497:PFDSM3638_RS01440
uniprot id: A0A5C0XMH9
uniprot id: Q8U400
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

186497:PFDSM3638 RS07285
gene id: 186497:PFDSM3638_RS07285
uniprot id: A0A5C0XS57
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS09970
gene id: 186497:PFDSM3638_RS09970
uniprot id: A0A5C0XS07
uniprot id: Q8TZL6
names: Function
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

186497:PFDSM3638 RS01800
gene id: 186497:PFDSM3638_RS01800
uniprot id: A0A5C0XMZ3
uniprot id: Q8U3T3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaB/Mog family.
messages: Catalyzes the adenylation of molybdopterin as part of the biosynthesis of the molybdenum-cofactor.
messages: Homohexamer.

186497:PFDSM3638 RS09305
gene id: 186497:PFDSM3638_RS09305
uniprot id: A0A5C0XU85
uniprot id: Q8TZY2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible SMC hinge near the middle of the molecule. These domains are separated by coiled-coil structures. The N- and C-terminus interact to make up an ATP-binding cassette-type ATPase domain. The SMC hinge domain mediates dimerization and binds DNA.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning (By similarity). Binds single-stranded but not double-stranded DNA.
messages: Required for chromosome condensation and partitioning.

186497:PFDSM3638 RS04500
gene id: 186497:PFDSM3638_RS04500
uniprot id: E7FI44
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Binds 1 nickel ion per heterotetramer.
messages: Cytoplasm
messages: Heterotetramer of alpha, beta, gamma and delta subunits. The nickel-containing alpha and delta subunits constitute the hydrogenase activity. The beta and gamma subunits (flavin-containing dimer) constitute the sulfur reductase activity.
messages: Part of a bifunctional enzyme complex that functions as an NADPH-dependent hydrogen-evolving hydrogenase with sulfur-reducing activity. May play a role in hydrogen cycling during fermentative growth. Activity not exhibited with NAD. The alpha and delta subunits form the hydrogenase component that catalyzes the reduction of protons to evolve hydrogen.

186497:PFDSM3638 RS02625
gene id: 186497:PFDSM3638_RS02625
uniprot id: A0A5C0XMY0
uniprot id: Q8U3E3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS07660
gene id: 186497:PFDSM3638_RS07660
uniprot id: A0A5C0XWH3
uniprot id: Q8U0R9
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

186497:PFDSM3638 RS02775
gene id: 186497:PFDSM3638_RS02775
uniprot id: A0A5C0XMY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

186497:PFDSM3638 RS05585
gene id: 186497:PFDSM3638_RS05585
uniprot id: A0A5C0XQF4
uniprot id: Q8U1U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

186497:PFDSM3638 RS09495
gene id: 186497:PFDSM3638_RS09495
uniprot id: A0A5C0XRS1
uniprot id: Q8TZV1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

186497:PFDSM3638 RS06915
gene id: 186497:PFDSM3638_RS06915
uniprot id: A0A5C0XQL3
uniprot id: P61998
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

186497:PFDSM3638 RS08530
gene id: 186497:PFDSM3638_RS08530
uniprot id: A0A5C0XR25
uniprot id: Q8U0C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

186497:PFDSM3638 RS07955
gene id: 186497:PFDSM3638_RS07955
uniprot id: A0A5C0XR24
uniprot id: Q8U0L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

186497:PFDSM3638 RS05680
gene id: 186497:PFDSM3638_RS05680
uniprot id: Q8U1S6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CRISPR system Cmr2 family.
messages: Binds 1 Zn(2+) ion per subunit.
messages: Binds 2 Ca(2+) per subunit, this may not be the physiological cation.
messages: Binds 4 Mn(2+) per subunit.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), formerly called psiRNA (prokaryotic silencing) in this organism. Part of the Cmr ribonucleoprotein complex which has divalent cation-dependent endoribonuclease activity specific for ssRNA complementary to the crRNA (target RNA), generating 5' hydroxy- and 3' phosphate or 2'-3' cyclic phosphate termini. Cmr4 is probably the subunit that cleaves target RNA (PubMed:25280103). Cmr complex does not cleave ssDNA complementary to the crRNA. Cleavage of target RNA is guided by the crRNA; substrate cleavage occurs a fixed distance (14 nt) from the 3' end of the crRNA. In vitro reconstitution shows Cmr1-2 and Cmr5 are not absolutely necessary for target cleavage (PubMed:19945378).
messages: Cytoplasm
messages: Part of the type III-B Cmr ribonucleoprotein (RNP) complex, an elongated RNP with Cmr2 and Cmr3 as the base, with Cmr4 and Cmr5 forming a helical core along the mature crRNA (39 or 45 nt in length), while the complex is capped by Cmr6 and Cmr1. The 5' end of the crRNA is bound to Cmr2 and Cmr3, while Cmr6 and a Cmr1 subunit (Cmr1-1 or Cmr1-2) cap the 3' end of the crRNA. The target RNA lies antiparallel to the crRNA, with its 5' end near Cmr1 and Cmr6 and its 3' end near Cmr2 and Cmr3; major target cleavage occurs nears the junction of Cmr1/Cmr6 and Cmr4/Cmr, with minor cleavage occurring at 6 nt intervals which coincide with the proposed spacing of Cmr4 subunits (PubMed:24119404, PubMed:25280103). Forms a 1:1 complex with Cmr3 (PubMed:23583914, PubMed:23395183). The Cmr2-Cmr3 complex non-specifically binds ss-target RNA and crRNA (PubMed:23583914). Interacts with Cmr3, Cmr4 and Cmr5 (PubMed:25280103).

186497:PFDSM3638 RS10380
gene id: 186497:PFDSM3638_RS10380
uniprot id: A0A5C0XSH1
uniprot id: Q8TZE1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS09150
gene id: 186497:PFDSM3638_RS09150
uniprot id: A0A5C0XS40
uniprot id: Q8U010
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS09135
gene id: 186497:PFDSM3638_RS09135
uniprot id: A0A5C0XRM5
uniprot id: Q8U013
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS09330
gene id: 186497:PFDSM3638_RS09330
uniprot id: A0A5C0XSX8
uniprot id: Q8TZX7
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

186497:PFDSM3638 RS05335
gene id: 186497:PFDSM3638_RS05335
uniprot id: A0A5C0XPJ9
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

186497:PFDSM3638 RS06495
gene id: 186497:PFDSM3638_RS06495
uniprot id: A0A5C0XRS4
names: Similarity
messages: Belongs to the UPF0201 family.

186497:PFDSM3638 RS09110
gene id: 186497:PFDSM3638_RS09110
uniprot id: A0A5C0XRC5
uniprot id: Q9HH80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit (PubMed:23222135). Contacts the 5S and 23S rRNAs (By similarity).
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

186497:PFDSM3638 RS07085
gene id: 186497:PFDSM3638_RS07085
uniprot id: A0A5C0XQL8
uniprot id: Q8U119
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS08620
gene id: 186497:PFDSM3638_RS08620
uniprot id: Q8U0A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMP lipoprotein family.
messages: Cell membrane

186497:PFDSM3638 RS08115
gene id: 186497:PFDSM3638_RS08115
uniprot id: P42180
names: Domain
names: Function
names: Subunit
messages: Consists of an N-terminal domain containing a helix-turn-helix (HtH) DNA-binding motif, and a C-terminal domain of mixed alpha/beta character reminiscent of a number of RNA- and DNA-binding domains.
messages: DNA-binding protein that negatively regulates its own transcription (PubMed:10973967, PubMed:11809882). Interferes with RNA polymerase (RNAP) recruitment by inhibiting the association of RNAP with the TBP-TFB promoter complex (PubMed:11809882). Binds to a 46-base pair sequence that overlaps the transcriptional start site of its own promoter (PubMed:10973967).
messages: Homooctamer; tetramer of dimers (PubMed:10973967, PubMed:11230123, PubMed:11375518). Forms a homodimer mainly through interactions between the antiparallel beta-sheets of the C-terminal domain, and further interactions lead to octamer formation (PubMed:11230123).

186497:PFDSM3638 RS03600
gene id: 186497:PFDSM3638_RS03600
uniprot id: A0A5C0XNN9
uniprot id: Q8U2V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

186497:PFDSM3638 RS00615
gene id: 186497:PFDSM3638_RS00615
uniprot id: A0A5C0XN71
uniprot id: Q8U4F3
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS10055
gene id: 186497:PFDSM3638_RS10055
uniprot id: A0A5C0XR87
uniprot id: Q8TZK1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Composed of only a NusG N-terminal (NGN) domain and a KOW domain, similar to bacterial NusG. The NGN domain is the effector domain of the complex that mediates the interaction with RNAP. The NGN domain closes the RNAP active center cleft to lock nucleic acids and render the elongation complex stable and processive. The KOW domain may interact with RNA and/or other factors.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP) independently of nucleic acids. Forms a homodimer in solution.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

186497:PFDSM3638 RS06040
gene id: 186497:PFDSM3638_RS06040
uniprot id: A0A5C0XSM9
names: Similarity
messages: Belongs to the AOR/FOR family.

186497:PFDSM3638 RS02030
gene id: 186497:PFDSM3638_RS02030
uniprot id: A0A5C0XMR4
uniprot id: Q8U3P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

186497:PFDSM3638 RS07175
gene id: 186497:PFDSM3638_RS07175
uniprot id: A0A5C0XQ98
uniprot id: Q8U102
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS00055
gene id: 186497:PFDSM3638_RS00055
uniprot id: A0A5C0XM93
uniprot id: Q8U4Q3
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity.

186497:PFDSM3638 RS09170
gene id: 186497:PFDSM3638_RS09170
uniprot id: A0A5C0XRL8
uniprot id: Q8U006
names: Similarity
messages: Belongs to the SUI1 family.

186497:PFDSM3638 RS04990
gene id: 186497:PFDSM3638_RS04990
uniprot id: A0A5C0XPM3
uniprot id: Q8U263
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

186497:PFDSM3638 RS03810
gene id: 186497:PFDSM3638_RS03810
uniprot id: A0A5C0XPP9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

186497:PFDSM3638 RS09445
gene id: 186497:PFDSM3638_RS09445
uniprot id: A0A5C0XRQ9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

186497:PFDSM3638 RS08845
gene id: 186497:PFDSM3638_RS08845
uniprot id: A0A5C0XRY1
uniprot id: Q8U063
names: Similarity
messages: Belongs to the class-I fumarase family.

186497:PFDSM3638 RS01035
gene id: 186497:PFDSM3638_RS01035
uniprot id: A0A5C0XMN2
uniprot id: Q8U474
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS09510
gene id: 186497:PFDSM3638_RS09510
uniprot id: A0A5C0XRT6
uniprot id: Q8TZU9
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS07230
gene id: 186497:PFDSM3638_RS07230
uniprot id: A0A5C0XQB2
uniprot id: Q8U0Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

186497:PFDSM3638 RS07855
gene id: 186497:PFDSM3638_RS07855
uniprot id: A0A5C0XRI7
uniprot id: Q8U0N4
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

186497:PFDSM3638 RS09915
gene id: 186497:PFDSM3638_RS09915
uniprot id: A0A5C0XTC4
uniprot id: Q8TZM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

186497:PFDSM3638 RS01930
gene id: 186497:PFDSM3638_RS01930
uniprot id: A0A5C0XMQ1
uniprot id: Q8U3R5
names: Similarity
messages: Belongs to the UPF0107 family.

186497:PFDSM3638 RS06970
gene id: 186497:PFDSM3638_RS06970
uniprot id: A0A5C0XQM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

186497:PFDSM3638 RS05655
gene id: 186497:PFDSM3638_RS05655
uniprot id: Q8U1T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CRISPR system Cmr6 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), formerly called psiRNA (prokaryotic silencing) in this organism. Part of the Cmr ribonucleoprotein complex which has divalent cation-dependent endoribonuclease activity specific for ssRNA complementary to the crRNA (target RNA), generating 5' hydroxy- and 3' phosphate or 2'-3' cyclic phosphate termini. Cmr4 is probably the subunit that cleaves target RNA (PubMed:25280103). Cmr complex does not cleave ssDNA complementary to the crRNA. Cleavage of invading RNA is guided by the crRNA; substrate cleavage occurs a fixed distance (14 nt) from the 3' end of the crRNA. In vitro reconstitution shows Cmr1-2 and Cmr5 are not absolutely necessary for target cleavage (PubMed:19945378).
messages: Cytoplasm
messages: Part of the type III-B Cmr ribonucleoprotein (RNP) complex, an elongated RNP with Cmr2 and Cmr3 as the base, with Cmr4 and Cmr5 forming a helical core along the mature crRNA (39 or 45 nt in length), while the complex is capped by Cmr6 and Cmr1. The 5' end of the crRNA is bound to Cmr2 and Cmr3, while Cmr6 and a Cmr1 subunit (Cmr1-1 or Cmr1-2) cap the 3' end of the crRNA. The target RNA lies antiparallel to the crRNA, with its 5' end near Cmr1 and Cmr6 and its 3' end near Cmr2 and Cmr3; major target cleavage occurs nears the junction of Cmr1/Cmr6 and Cmr4/Cmr, with minor cleavage occurring at 6 nt intervals which coincide with the proposed spacing of Cmr4 subunits (PubMed:24119404, PubMed:25280103). Interacts with Cmr4 and Cmr5 (PubMed:25280103).

186497:PFDSM3638 RS04105
gene id: 186497:PFDSM3638_RS04105
uniprot id: A0A5C0XNM3
uniprot id: Q8U2L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

186497:PFDSM3638 RS09695
gene id: 186497:PFDSM3638_RS09695
uniprot id: A0A5C0XSD7
uniprot id: P62002
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

186497:PFDSM3638 RS08985
gene id: 186497:PFDSM3638_RS08985
uniprot id: A0A5C0XQP1
uniprot id: Q8U036
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

186497:PFDSM3638 RS07665
gene id: 186497:PFDSM3638_RS07665
uniprot id: A0A5C0XQZ6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

186497:PFDSM3638 RS02520
gene id: 186497:PFDSM3638_RS02520
uniprot id: A0A5C0XMX0
uniprot id: Q8U3G4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

186497:PFDSM3638 RS05320
gene id: 186497:PFDSM3638_RS05320
uniprot id: A0A5C0XNG8
uniprot id: Q8U1Z8
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

186497:PFDSM3638 RS07300
gene id: 186497:PFDSM3638_RS07300
uniprot id: A0A5C0XQS9
uniprot id: Q8U0X9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS10200
gene id: 186497:PFDSM3638_RS10200
uniprot id: A0A5C0XXW2
uniprot id: Q8TZH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer (By similarity).
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex (By similarity).
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

186497:PFDSM3638 RS08290
gene id: 186497:PFDSM3638_RS08290
uniprot id: A0A5C0XQY5
uniprot id: P56709
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
messages: Monomer.

186497:PFDSM3638 RS01475
gene id: 186497:PFDSM3638_RS01475
uniprot id: A0A5C0XM88
uniprot id: Q8U3Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

186497:PFDSM3638 RS05165
gene id: 186497:PFDSM3638_RS05165
uniprot id: A0A5C0XNX3
uniprot id: Q8U227
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

186497:PFDSM3638 RS08800
gene id: 186497:PFDSM3638_RS08800
uniprot id: A0A5C0XR81
uniprot id: Q8U070
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19 (Probable).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

186497:PFDSM3638 RS08645
gene id: 186497:PFDSM3638_RS08645
uniprot id: A0A5C0XR41
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

186497:PFDSM3638 RS05865
gene id: 186497:PFDSM3638_RS05865
uniprot id: A0A5C0XVK1
uniprot id: P58301
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binding of ATP induces a closed, compact conformation of the Rad50/Mre11 complex. ATP hydrolysis opens the complex.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer (PubMed:10892749, PubMed:14698290). Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits (PubMed:11371344, PubMed:21441914, PubMed:22102415). Homodimerization is promoted by ATP binding (PubMed:10892749).
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair (PubMed:11029422, PubMed:18957200). The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA (PubMed:18957200). Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex (PubMed:24493214). The ATP-bound conformation promotes DNA end binding and end tethering, and alters Mre11 nuclease activity (PubMed:24493214). ATP hydrolysis promotes both Mre11 activity as well as HerA/NurA activity (PubMed:24493214). Has also reversible adenylate kinase activity (PubMed:17349953).
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The adenylate kinase inhibitor P(1),P(5)-di(adenosine-5') pentaphosphate (Ap5A) inhibits adenylate kinase activity, but does not affect ATPase activity.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

186497:PFDSM3638 RS02365
gene id: 186497:PFDSM3638_RS02365
uniprot id: A0A5C0XMV0
uniprot id: Q8U3J2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Divalent metal cation. Highest activity with cobalt or manganese.
messages: Has ATPase and non-specific DNA-binding activities.
messages: Has ATPase and non-specific DNA-binding activities. May be involved in recombination and/or recombinational repair. Not involved in mismatch repair.
messages: Multimer.

186497:PFDSM3638 RS09370
gene id: 186497:PFDSM3638_RS09370
uniprot id: A0A5C0XS74
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS08250
gene id: 186497:PFDSM3638_RS08250
uniprot id: A0A5C0XR76
uniprot id: Q8U0G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

186497:PFDSM3638 RS08365
gene id: 186497:PFDSM3638_RS08365
uniprot id: A0A5C0XWV1
uniprot id: Q8U0E3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS07520
gene id: 186497:PFDSM3638_RS07520
uniprot id: A0A5C0XS99
uniprot id: Q8U0U1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS17 family.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS08345
gene id: 186497:PFDSM3638_RS08345
uniprot id: A0A5C0XQZ8
uniprot id: Q8U0E6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

186497:PFDSM3638 RS08635
gene id: 186497:PFDSM3638_RS08635
uniprot id: A0A5C0XRU3
uniprot id: Q8U0A1
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS09395
gene id: 186497:PFDSM3638_RS09395
uniprot id: A0A5C0XRQ0
uniprot id: Q8TZW4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M42 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 2 divalent metal cations per subunit.
messages: Homotetramer.
messages: Hydrolyzes di-, tri- and tetrapeptides with a lysine as the N-terminal amino acid and with Gly, Lys, Ala, Phe or Glu in the second position.

186497:PFDSM3638 RS06080
gene id: 186497:PFDSM3638_RS06080
uniprot id: A0A5C0XQA0
uniprot id: Q8U1J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

186497:PFDSM3638 RS04950
gene id: 186497:PFDSM3638_RS04950
uniprot id: A0A5C0XQ55
uniprot id: Q8U269
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

186497:PFDSM3638 RS07330
gene id: 186497:PFDSM3638_RS07330
uniprot id: A0A5C0XQD2
uniprot id: Q8U0X3
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

186497:PFDSM3638 RS04900
gene id: 186497:PFDSM3638_RS04900
uniprot id: A0A5C0XNA5
uniprot id: Q51800
names: Cofactor
names: Subunit
messages: Binds 2 [4Fe-4S] clusters.
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

186497:PFDSM3638 RS06190
gene id: 186497:PFDSM3638_RS06190
uniprot id: A0A5C0XQ71
uniprot id: Q8U1H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

186497:PFDSM3638 RS07950
gene id: 186497:PFDSM3638_RS07950
uniprot id: A0A5C0XR40
uniprot id: Q8U0L9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteromeric RNA-tails.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

186497:PFDSM3638 RS10065
gene id: 186497:PFDSM3638_RS10065
uniprot id: A0A5C0XSK5
uniprot id: Q8TZJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

186497:PFDSM3638 RS03155
gene id: 186497:PFDSM3638_RS03155
uniprot id: A0A5C0XNV2
uniprot id: Q8U341
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

186497:PFDSM3638 RS00940
gene id: 186497:PFDSM3638_RS00940
uniprot id: A0A5C0XNC0
uniprot id: Q8U491
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

186497:PFDSM3638 RS02190
gene id: 186497:PFDSM3638_RS02190
uniprot id: A0A5C0XQP5
uniprot id: E7FHX6
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: 5'-deoxyadenosylcobalamine (coenzyme B12).
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

186497:PFDSM3638 RS05605
gene id: 186497:PFDSM3638_RS05605
uniprot id: A0A5C0XPQ1
uniprot id: Q8U1U1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

186497:PFDSM3638 RS00945
gene id: 186497:PFDSM3638_RS00945
uniprot id: A0A5C0XLU0
uniprot id: Q8U490
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS08740
gene id: 186497:PFDSM3638_RS08740
uniprot id: A0A5C0XQ02
uniprot id: Q51732
names: Biotechnology
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Being able to prevent acrylamide formation at 100 degrees Celsius, this enzyme could constitute a viable and unique enzymatic method to reduce acrylamide formation in food, whose presence is a worldwide concern because it is carcinogenic, reprotoxic and neurotoxic. The use of deglycases is not likely to affect the quality parameters of foods, in contrast with methods which lead to depletion of the components (asparagine and sugars) responsible for acrylamide formation. Moreover, deglycases can be used directly during the thermal process, which avoids a time consuming pre-incubation step. Consequently, many foods whose heating processes occur at around 100 degrees Celsius, such as baby foods, evaporated milk, dry soups and prune juices could be clients of the deglycase method.
messages: Belongs to the peptidase C56 family.
messages: Cytoplasm
messages: Deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins and reactive carbonyl groups of glyoxals (Probable). Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively (PubMed:27530919). Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals (By similarity). Thus, was shown to afford full protection against glycation of thioredoxin by glyoxal (PubMed:27530919). Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (By similarity). Prevents acrylamide formation in asparagine/glyoxal and asparagine/sugar mixtures, likely by degrading asparagine/glyoxal Maillard adducts formed at high temperatures (PubMed:27530919). Also displays proteolytic activity (PubMed:8626329, PubMed:16535492). Cleaves at the carboxyl side of both basic and hydrophobic residues in the P1 position, indicating trypsin- and chymotrypsin-like specificities (PubMed:16535492).
messages: Homooligomer (PubMed:8626329). Exists in two functional species: the predominant form is a homohexamer that comprises about 90% of the total activity, and the minor form is trimeric (PubMed:16535492).

186497:PFDSM3638 RS04385
gene id: 186497:PFDSM3638_RS04385
uniprot id: A0A5C0XNP9
uniprot id: Q8U2G6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS08100
gene id: 186497:PFDSM3638_RS08100
uniprot id: A0A5C0XR68
uniprot id: Q8U0I9
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

186497:PFDSM3638 RS05620
gene id: 186497:PFDSM3638_RS05620
uniprot id: A0A5C0XPX3
uniprot id: Q8U1T8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

186497:PFDSM3638 RS05085
gene id: 186497:PFDSM3638_RS05085
uniprot id: A0A5C0XV50
uniprot id: Q8U243
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

186497:PFDSM3638 RS09185
gene id: 186497:PFDSM3638_RS09185
uniprot id: A0A5C0XRN2
uniprot id: Q8U003
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

186497:PFDSM3638 RS08070
gene id: 186497:PFDSM3638_RS08070
uniprot id: A0A5C0XRL3
uniprot id: Q8U0J5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

186497:PFDSM3638 RS02925
gene id: 186497:PFDSM3638_RS02925
uniprot id: A0A5C0XQ05
uniprot id: Q8U388
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS08360
gene id: 186497:PFDSM3638_RS08360
uniprot id: A0A5C0XR95
uniprot id: Q8U0E4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

186497:PFDSM3638 RS02735
gene id: 186497:PFDSM3638_RS02735
uniprot id: A0A5C0XPA7
uniprot id: Q8U3C6
names: Similarity
messages: Belongs to the UPF0047 family.

186497:PFDSM3638 RS07205
gene id: 186497:PFDSM3638_RS07205
uniprot id: Q8U0Z6
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alpha subunit of a hydrogen-evolving hydrogenase that utilizes protons both as a substrate for hydrogen production and proton translocation. Acts by coupling the redox reaction via ferredoxin and iron-sulfur (Fe-S) clusters to proton translocation across the membrane thereby conserving the redox energy in a proton gradient.
messages: Belongs to the complex I 49 kDa subunit family.
messages: Binds 1 nickel ion per mole of protein.
messages: Cell membrane
messages: Inhibited by 0.1 mM Cu(2+).
messages: The membrane-bound hydrogenase complex is composed of MbhK and MbhL, and may also contain MbhJ.
messages: The subunit composition of membrane-bound hydrogenase complex is currently unclear. It has been shown to be a heterodimer of MbhK and MbhL (PubMed:10852873). Other studies have shown it to contain MbhJ in addition to MbhK and MbhL (PubMed:11054105).

186497:PFDSM3638 RS09405
gene id: 186497:PFDSM3638_RS09405
uniprot id: A0A5C0XRS0
uniprot id: Q8TH24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

186497:PFDSM3638 RS09895
gene id: 186497:PFDSM3638_RS09895
uniprot id: A0A5C0XUJ5
uniprot id: P58814
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Homotetramer.
messages: Inhibited to approximately 20% by EDTA.

186497:PFDSM3638 RS07525
gene id: 186497:PFDSM3638_RS07525
uniprot id: A0A5C0XQV2
uniprot id: Q8U0U0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

186497:PFDSM3638 RS08695
gene id: 186497:PFDSM3638_RS08695
uniprot id: A0A5C0XR53
uniprot id: Q8U089
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS02300
gene id: 186497:PFDSM3638_RS02300
uniprot id: A0A5C0XP34
uniprot id: Q8U3K4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane

186497:PFDSM3638 RS07250
gene id: 186497:PFDSM3638_RS07250
uniprot id: A0A5C0XQS3
uniprot id: Q8U0Y9
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

186497:PFDSM3638 RS07975
gene id: 186497:PFDSM3638_RS07975
uniprot id: A0A5C0XPM7
uniprot id: Q8U0L4
names: Similarity
messages: Belongs to the peptidase U62 family.

186497:PFDSM3638 RS06325
gene id: 186497:PFDSM3638_RS06325
uniprot id: A0A5C0XNV0
uniprot id: Q8U1E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

186497:PFDSM3638 RS05415
gene id: 186497:PFDSM3638_RS05415
uniprot id: A0A5C0XQC9
uniprot id: Q8U1X8
names: Similarity
messages: Belongs to the peptidase U62 family.

186497:PFDSM3638 RS07795
gene id: 186497:PFDSM3638_RS07795
uniprot id: A0A5C0XRH9
uniprot id: Q8U0P4
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

186497:PFDSM3638 RS09005
gene id: 186497:PFDSM3638_RS09005
uniprot id: A0A5C0XRB0
uniprot id: Q7LWY0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

186497:PFDSM3638 RS07280
gene id: 186497:PFDSM3638_RS07280
uniprot id: A0A5C0XQC3
uniprot id: Q8U0Y3
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS07810
gene id: 186497:PFDSM3638_RS07810
uniprot id: A0A5C0XSE5
uniprot id: Q8U0P1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

186497:PFDSM3638 RS00385
gene id: 186497:PFDSM3638_RS00385
uniprot id: A0A5C0XPT7
uniprot id: Q9UWR2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Heteromultimer composed of three to four small subunits (RfcS) and one to two large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA.
messages: The C-terminal basic cluster region, which consists mainly of lysine residues, is important for the formation of a stable RFC-PCNA-DNA complex, although it is not critical for loading PCNA onto DNA in vitro (PubMed:16172520). An 11-mer corresponding to the PIP-box inhibits DNA synthesis by Pol I (pol).

186497:PFDSM3638 RS06940
gene id: 186497:PFDSM3638_RS06940
uniprot id: A0A5C0XP67
uniprot id: Q8U147
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

186497:PFDSM3638 RS02605
gene id: 186497:PFDSM3638_RS02605
uniprot id: A0A5C0XMW7
uniprot id: Q8U3E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

186497:PFDSM3638 RS10440
gene id: 186497:PFDSM3638_RS10440
uniprot id: A0A5C0XSR4
uniprot id: Q8TZD1
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.
messages: Belongs to the radical SAM superfamily. NifB family.

186497:PFDSM3638 RS05215
gene id: 186497:PFDSM3638_RS05215
uniprot id: A0A5C0XNF3
uniprot id: P58861
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

186497:PFDSM3638 RS05735
gene id: 186497:PFDSM3638_RS05735
uniprot id: A0A5C0XQH6
uniprot id: Q8U1R5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

186497:PFDSM3638 RS00010
gene id: 186497:PFDSM3638_RS00010
uniprot id: A0A5C0XLM6
uniprot id: P81412
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

186497:PFDSM3638 RS06645
gene id: 186497:PFDSM3638_RS06645
uniprot id: A0A5C0XSY5
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

186497:PFDSM3638 RS04715
gene id: 186497:PFDSM3638_RS04715
uniprot id: A0A5C0XPL6
uniprot id: Q8U2A4
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

186497:PFDSM3638 RS09210
gene id: 186497:PFDSM3638_RS09210
uniprot id: A0A5C0XRE2
uniprot id: Q8TZZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit (PubMed:23222135). Forms a cluster with proteins L14 and L24e.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

186497:PFDSM3638 RS05990
gene id: 186497:PFDSM3638_RS05990
uniprot id: A0A5C0XSM2
names: Subcellular Location Annotation
messages: Encapsulin nanocompartment

186497:PFDSM3638 RS03220
gene id: 186497:PFDSM3638_RS03220
uniprot id: A0A5C0XPG5
uniprot id: Q8U331
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

186497:PFDSM3638 RS00415
gene id: 186497:PFDSM3638_RS00415
uniprot id: A0A5C0XSY0
uniprot id: Q8U4I9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

186497:PFDSM3638 RS02415
gene id: 186497:PFDSM3638_RS02415
uniprot id: A0A5C0XMV7
uniprot id: Q8U3I2
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

186497:PFDSM3638 RS09905
gene id: 186497:PFDSM3638_RS09905
uniprot id: A0A5C0XQP0
uniprot id: E7FHG8
names: Similarity
messages: Belongs to the AOR/FOR family.

186497:PFDSM3638 RS01030
gene id: 186497:PFDSM3638_RS01030
uniprot id: A0A5C0XN13
uniprot id: Q8U475
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS06845
gene id: 186497:PFDSM3638_RS06845
uniprot id: A0A5C0XR33
uniprot id: Q8U160
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: May be present in up to 3 copies per 70S ribosome (PubMed:23222135). Part of the 50S ribosomal subunit, where it binds 23S rRNA at its canonical site near the L1 stalk, as well as a possible second 50S binding site near helix 25 and a possible third site on the beak of the 30S subunit (PubMed:23222135). Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA. These sRNP particles form homodimers, giving rise to an asymmetric holoenzyme. Probably part of the RNase P complex (PubMed:20864039).
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. Component of the 70S ribosome (PubMed:23222135). Component of a box C/D small ribonucleoprotein (sRNP) particle that is involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

186497:PFDSM3638 RS04880
gene id: 186497:PFDSM3638_RS04880
uniprot id: A0A5C0XPK0
uniprot id: Q51804
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

186497:PFDSM3638 RS02755
gene id: 186497:PFDSM3638_RS02755
uniprot id: A0A5C0XND1
uniprot id: Q8U3C2
names: Similarity
messages: Belongs to the HupF/HypC family.

186497:PFDSM3638 RS08190
gene id: 186497:PFDSM3638_RS08190
uniprot id: A0A5C0XS65
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

186497:PFDSM3638 RS07040
gene id: 186497:PFDSM3638_RS07040
uniprot id: A0A5C0XPV8
uniprot id: Q8U128
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

186497:PFDSM3638 RS10165
gene id: 186497:PFDSM3638_RS10165
uniprot id: A0A5C0XRG6
uniprot id: Q8TZI3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

186497:PFDSM3638 RS00460
gene id: 186497:PFDSM3638_RS00460
uniprot id: A0A5C0XND8
uniprot id: Q8U4H9
names: Subunit
messages: Homotetramer.

186497:PFDSM3638 RS00845
gene id: 186497:PFDSM3638_RS00845
uniprot id: A0A5C0XM86
uniprot id: Q8U4A8
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

186497:PFDSM3638 RS10175
gene id: 186497:PFDSM3638_RS10175
uniprot id: A0A5C0XSM3
uniprot id: Q8TZI1
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

186497:PFDSM3638 RS00510
gene id: 186497:PFDSM3638_RS00510
uniprot id: A0A5C0XM50
uniprot id: Q8U4H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

186497:PFDSM3638 RS06020
gene id: 186497:PFDSM3638_RS06020
uniprot id: A0A5C0XVM9
uniprot id: Q8U1K8
names: Similarity
messages: Belongs to the SfsA family.

186497:PFDSM3638 RS09640
gene id: 186497:PFDSM3638_RS09640
uniprot id: A0A5C0XUE5
uniprot id: P29603
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster which readily converts to a stable [3Fe-4S] form.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
messages: Homodimer.

186497:PFDSM3638 RS06475
gene id: 186497:PFDSM3638_RS06475
uniprot id: A0A5C0XSV5
uniprot id: Q8U1C4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

186497:PFDSM3638 RS09180
gene id: 186497:PFDSM3638_RS09180
uniprot id: A0A5C0XRN0
uniprot id: Q8U004
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS09765
gene id: 186497:PFDSM3638_RS09765
uniprot id: A0A5C0XRW8
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

186497:PFDSM3638 RS01960
gene id: 186497:PFDSM3638_RS01960
uniprot id: A0A5C0XMI5
uniprot id: Q8U3Q9
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.

186497:PFDSM3638 RS01235
gene id: 186497:PFDSM3638_RS01235
uniprot id: A0A5C0XMR6
uniprot id: Q8U436
names: Similarity
messages: Belongs to the UPF0045 family.

186497:PFDSM3638 RS06400
gene id: 186497:PFDSM3638_RS06400
uniprot id: A0A5C0XQA6
uniprot id: E7FHF1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of 7,8-dihydroneopterin monophosphate (H2NMP) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD). Cannot use 7,8-dihydroneopterin (H2Neo) or 7,8-dihydroneopterin triphosphate (H2NTP) as substrate.

186497:PFDSM3638 RS05855
gene id: 186497:PFDSM3638_RS05855
uniprot id: A0A5C0XRC1
uniprot id: Q8U1P0
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HerA family.
messages: Helicase activity is stimulated in the presence of NurA.
messages: Homohexamer (PubMed:18957200). Interacts with NurA (PubMed:18957200).
messages: Involved in DNA double-strand break (DSB) repair (PubMed:18957200). Acts probably with NurA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (PubMed:18957200). Exhibits DNA-dependent ATPase activity and DNA helicase activity (By similarity) (PubMed:18957200).

186497:PFDSM3638 RS05920
gene id: 186497:PFDSM3638_RS05920
uniprot id: A0A5C0XVL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

186497:PFDSM3638 RS05540
gene id: 186497:PFDSM3638_RS05540
uniprot id: A0A5C0XR70
uniprot id: Q8U1V3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

186497:PFDSM3638 RS01210
gene id: 186497:PFDSM3638_RS01210
uniprot id: A0A5C0XQ76
uniprot id: Q8U441
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

186497:PFDSM3638 RS03835
gene id: 186497:PFDSM3638_RS03835
uniprot id: A0A5C0XNQ9
uniprot id: Q8U2R2
names: Similarity
messages: Belongs to the UDPGP type 2 family.

186497:PFDSM3638 RS05070
gene id: 186497:PFDSM3638_RS05070
uniprot id: A0A5C0XNV4
uniprot id: Q8U246
names: Similarity
messages: Belongs to the alkaline phosphatase family.

186497:PFDSM3638 RS09360
gene id: 186497:PFDSM3638_RS09360
uniprot id: A0A5C0XQV4
uniprot id: Q8TZX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

186497:PFDSM3638 RS07355
gene id: 186497:PFDSM3638_RS07355
uniprot id: A0A5C0XQR9
uniprot id: Q8U0W9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

186497:PFDSM3638 RS01265
gene id: 186497:PFDSM3638_RS01265
uniprot id: A0A5C0XNH4
uniprot id: Q8U430
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

186497:PFDSM3638 RS07505
gene id: 186497:PFDSM3638_RS07505
uniprot id: A0A5C0XRD6
uniprot id: Q8U0U4
names: Similarity
messages: Belongs to the UPF0128 family.

186497:PFDSM3638 RS09745
gene id: 186497:PFDSM3638_RS09745
uniprot id: A0A5C0XSE8
uniprot id: Q8TZQ6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

186497:PFDSM3638 RS03035
gene id: 186497:PFDSM3638_RS03035
uniprot id: A0A5C0XU79
names: Similarity
messages: Belongs to the HypE family.

186497:PFDSM3638 RS08195
gene id: 186497:PFDSM3638_RS08195
uniprot id: A0A5C0XSL0
uniprot id: Q8U0H3
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

186497:PFDSM3638 RS00005
gene id: 186497:PFDSM3638_RS00005
uniprot id: A0A5C0XM79
uniprot id: P81413
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CDC6/cdc18 family.
messages: Homodimer (Probable). Interacts with MCM.
messages: Involved in regulation of DNA replication.
messages: Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA.

186497:PFDSM3638 RS08710
gene id: 186497:PFDSM3638_RS08710
uniprot id: A0A5C0XX09
uniprot id: Q8U086
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

186497:PFDSM3638 RS00925
gene id: 186497:PFDSM3638_RS00925
uniprot id: A0A5C0XML8
uniprot id: P83194
names: Activity Regulation
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal-type GPI family.
messages: Binds 1 Fe cation per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Inhibited by mannose 6-phosphate, fructose 1-phosphate and fructose 1,6-bisphosphate.

186497:PFDSM3638 RS01360
gene id: 186497:PFDSM3638_RS01360
uniprot id: A0A5C0XMS6
uniprot id: P42851
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

186497:PFDSM3638 RS02025
gene id: 186497:PFDSM3638_RS02025
uniprot id: A0A5C0XM69
uniprot id: Q8U3P6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Cell membrane
messages: Despite low primary sequence conservation between eukaryotic catalytic subunits and bacterial and archaeal single subunit OSTs (ssOST), structural comparison revealed several common motifs at spatially equivalent positions, like the DXD motif 1 on the external loop 1 and the DXD motif 2 on the external loop 2 involved in binding of the metal ion cofactor and the carboxamide group of the acceptor asparagine, the conserved Glu residue of the TIXE/SVSE motif on the external loop 5 involved in catalysis, as well as the WWDYG and the DK/MI motifs in the globular domain that define the binding pocket for the +2 Ser/Thr of the acceptor sequon. In bacterial ssOSTs, an Arg residue was found to interact with a negatively charged side chain at the -2 position of the sequon. This Arg is conserved in bacterial enzymes and correlates with an extended sequon requirement (Asp-X-Asn-X-Ser/Thr) for bacterial N-glycosylation.
messages: Membrane
messages: Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (ManNAcXyl(2)GlcAMan(2)GalNAc in P.furiosus) from the lipid carrier dolichol-monophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.

186497:PFDSM3638 RS09665
gene id: 186497:PFDSM3638_RS09665
uniprot id: A0A5C0XRU9
uniprot id: Q8TZS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits. Forms a subcomplex with Rnp2 which stimulates the catalytic RNA.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. The RNA is catalytic, but its KM for pre-tRNA is 170-fold decreased in the presence of the 4 known protein subunits (Rnp1-4). The protein subunits also decrease the amount of Mg(2+) needed for activity.

186497:PFDSM3638 RS07890
gene id: 186497:PFDSM3638_RS07890
uniprot id: A0A5C0XR14
uniprot id: P61995
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

186497:PFDSM3638 RS02215
gene id: 186497:PFDSM3638_RS02215
uniprot id: A0A5C0XN64
uniprot id: Q9HHB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Is very specific for its substrate, since it is not able to use D-glucose, D-fructose, D-mannose, 2-deoxy-D-glucose, and D-glucosamine as substrates.
messages: Cytoplasm
messages: Monomer.

186497:PFDSM3638 RS09100
gene id: 186497:PFDSM3638_RS09100
uniprot id: A0A5C0XS30
uniprot id: Q9HH78
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS00295
gene id: 186497:PFDSM3638_RS00295
uniprot id: A0A5C0XM25
uniprot id: E7FHY4
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

186497:PFDSM3638 RS09240
gene id: 186497:PFDSM3638_RS09240
uniprot id: A0A5C0XQT5
uniprot id: P61882
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm
messages: Homodimer or heterodimer with another histone. Dimers then assemble into higher oligomers, with the DNA wrapped around the protein core (By similarity).

186497:PFDSM3638 RS02380
gene id: 186497:PFDSM3638_RS02380
uniprot id: A0A5C0XTV7
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

186497:PFDSM3638 RS05895
gene id: 186497:PFDSM3638_RS05895
uniprot id: A0A5C0XQJ8
uniprot id: Q8U1N4
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in tRNA.

186497:PFDSM3638 RS07135
gene id: 186497:PFDSM3638_RS07135
uniprot id: A0A5C0XQM7
uniprot id: Q8U111
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

186497:PFDSM3638 RS00575
gene id: 186497:PFDSM3638_RS00575
uniprot id: A0A5C0XT07
uniprot id: Q8U4F8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

186497:PFDSM3638 RS02480
gene id: 186497:PFDSM3638_RS02480
uniprot id: A0A5C0XN96
uniprot id: Q8U3H1
names: Domain
names: Function
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.
messages: Binds to the maltodextrin transport gene cluster (mdxE operon) promoter and to some other TGM (Thermococcales-Glycolytic-Motif) sequences, but not exclusively.
messages: Lacks the C-terminal sugar-binding domain.

186497:PFDSM3638 RS01820
gene id: 186497:PFDSM3638_RS01820
uniprot id: A0A5C0XM49
uniprot id: Q8U3T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS08755
gene id: 186497:PFDSM3638_RS08755
uniprot id: A0A5C0XRU5
uniprot id: O59627
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm
messages: Homodimer or heterodimer with another histone. Dimers then assemble into higher oligomers, with the DNA wrapped around the protein core (By similarity).

186497:PFDSM3638 RS06220
gene id: 186497:PFDSM3638_RS06220
uniprot id: A0A5C0XQQ6
uniprot id: Q8U1G7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

186497:PFDSM3638 RS01385
gene id: 186497:PFDSM3638_RS01385
uniprot id: A0A5C0XLY4
uniprot id: Q8U410
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS08905
gene id: 186497:PFDSM3638_RS08905
uniprot id: A0A5C0XR94
uniprot id: Q8U052
names: Similarity
messages: Belongs to the UPF0235 family.

186497:PFDSM3638 RS09140
gene id: 186497:PFDSM3638_RS09140
uniprot id: A0A5C0XQR6
uniprot id: Q8U012
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit (PubMed:23222135); contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

186497:PFDSM3638 RS00930
gene id: 186497:PFDSM3638_RS00930
uniprot id: A0A5C0XM26
uniprot id: Q8U493
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

186497:PFDSM3638 RS00840
gene id: 186497:PFDSM3638_RS00840
uniprot id: A0A5C0XLT1
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

186497:PFDSM3638 RS01350
gene id: 186497:PFDSM3638_RS01350
uniprot id: A0A5C0XTC6
uniprot id: Q8U414
names: Similarity
messages: Belongs to the acylphosphatase family.

186497:PFDSM3638 RS04315
gene id: 186497:PFDSM3638_RS04315
uniprot id: A0A5C0XUT0
uniprot id: Q8U2H8
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS03205
gene id: 186497:PFDSM3638_RS03205
uniprot id: A0A5C0XNV9
uniprot id: Q8U334
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-A/Apern subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

186497:PFDSM3638 RS08675
gene id: 186497:PFDSM3638_RS08675
uniprot id: A0A5C0XQI7
uniprot id: Q8U093
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

186497:PFDSM3638 RS08735
gene id: 186497:PFDSM3638_RS08735
uniprot id: A0A5C0XRW2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

186497:PFDSM3638 RS07900
gene id: 186497:PFDSM3638_RS07900
uniprot id: A0A5C0XTJ2
uniprot id: Q8U0M6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL30 family.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS06760
gene id: 186497:PFDSM3638_RS06760
uniprot id: A0A5C0XP30
uniprot id: Q8U176
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (By similarity). Also edits incorrectly charged L-seryl-tRNA(Thr) (PubMed:26113036).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain (about residues 1-143) is an archaea-specific tRNA-editing domain (PubMed:26113036). Catalysis of tRNA editing is performed by the charged tRNA itself (By similarity).

186497:PFDSM3638 RS10110
gene id: 186497:PFDSM3638_RS10110
uniprot id: A0A5C0XR97
uniprot id: Q8TZJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

186497:PFDSM3638 RS06050
gene id: 186497:PFDSM3638_RS06050
uniprot id: A0A5C0XNQ7
uniprot id: Q8U1K1
names: Caution
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

186497:PFDSM3638 RS08875
gene id: 186497:PFDSM3638_RS08875
uniprot id: A0A5C0XRI5
uniprot id: Q8U058
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS09190
gene id: 186497:PFDSM3638_RS09190
uniprot id: A0A5C0XQS6
uniprot id: Q8U002
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Part of the 30S ribosomal subunit.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

186497:PFDSM3638 RS09500
gene id: 186497:PFDSM3638_RS09500
uniprot id: A0A5C0XXJ1
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

186497:PFDSM3638 RS09465
gene id: 186497:PFDSM3638_RS09465
uniprot id: P61996
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the encapsulin family. Family 4B subfamily.
messages: Encapsulin nanocompartment
messages: May be the encapsulin shell protein in a type 4 A-domain encapsulin nanocompartment system. Its cargo may be upstream glyceraldehyde-3-phosphate dehydrogenase (AC P61879).
messages: May self-assemble into facets and potentially into larger complexes.

186497:PFDSM3638 RS00805
gene id: 186497:PFDSM3638_RS00805
uniprot id: A0A5C0XML6
uniprot id: Q8U4B6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

186497:PFDSM3638 RS06395
gene id: 186497:PFDSM3638_RS06395
uniprot id: A0A5C0XSE2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS05195
gene id: 186497:PFDSM3638_RS05195
uniprot id: A0A5C0XP13
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

186497:PFDSM3638 RS04995
gene id: 186497:PFDSM3638_RS04995
uniprot id: A0A5C0XNY2
uniprot id: Q8U262
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS08765
gene id: 186497:PFDSM3638_RS08765
uniprot id: A0A5C0XX19
uniprot id: Q8U077
names: Cofactor
names: Similarity
messages: Belongs to the UPF0292 family.
messages: Binds two Mg(2+) per subunit.

186497:PFDSM3638 RS05445
gene id: 186497:PFDSM3638_RS05445
uniprot id: A0A5C0XVC0
uniprot id: Q8U1X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

186497:PFDSM3638 RS04745
gene id: 186497:PFDSM3638_RS04745
uniprot id: A0A5C0XNQ5
uniprot id: Q8U298
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

186497:PFDSM3638 RS00745
gene id: 186497:PFDSM3638_RS00745
uniprot id: A0A5C0XNU1
uniprot id: Q8U4C8
names: Similarity
messages: Belongs to the peptidase U62 family.

186497:PFDSM3638 RS06450
gene id: 186497:PFDSM3638_RS06450
uniprot id: A0A5C0XQB7
uniprot id: E7FHT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

186497:PFDSM3638 RS05830
gene id: 186497:PFDSM3638_RS05830
uniprot id: A0A5C0XPB8
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

186497:PFDSM3638 RS01450
gene id: 186497:PFDSM3638_RS01450
uniprot id: A0A5C0XMU6
uniprot id: Q8U3Z8
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

186497:PFDSM3638 RS01255
gene id: 186497:PFDSM3638_RS01255
uniprot id: A0A5C0XM61
uniprot id: Q8U432
names: Similarity
messages: Belongs to the GbsR family.

186497:PFDSM3638 RS04560
gene id: 186497:PFDSM3638_RS04560
uniprot id: A0A5C0XNR5
uniprot id: Q8U2D5
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.
messages: Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif).
messages: DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS07495
gene id: 186497:PFDSM3638_RS07495
uniprot id: A0A5C0XQ31
uniprot id: Q8U0U6
names: Similarity
messages: Belongs to the UPF0212 family.

186497:PFDSM3638 RS09925
gene id: 186497:PFDSM3638_RS09925
uniprot id: A0A5C0XXR6
uniprot id: Q8TZM5
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

186497:PFDSM3638 RS09115
gene id: 186497:PFDSM3638_RS09115
uniprot id: A0A5C0XT15
uniprot id: Q8U016
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS07050
gene id: 186497:PFDSM3638_RS07050
uniprot id: A0A5C0XR58
uniprot id: Q8U126
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

186497:PFDSM3638 RS08305
gene id: 186497:PFDSM3638_RS08305
uniprot id: A0A5C0XWU0
uniprot id: Q8U0F2
names: Similarity
messages: Belongs to the MEMO1 family.

186497:PFDSM3638 RS04140
gene id: 186497:PFDSM3638_RS04140
uniprot id: A0A5C0XUQ1
uniprot id: Q8U2K7
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Catalyzes the formation of 5-methyl-uridine at position equivalent to 747 (m5U747) in 23S rRNA.

186497:PFDSM3638 RS06470
gene id: 186497:PFDSM3638_RS06470
uniprot id: A0A5C0XPL3
uniprot id: Q8U1C5
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS10085
gene id: 186497:PFDSM3638_RS10085
uniprot id: A0A5C0XS25
uniprot id: Q8X251
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS07265
gene id: 186497:PFDSM3638_RS07265
uniprot id: A0A5C0XT86
uniprot id: Q8U0Y6
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS08790
gene id: 186497:PFDSM3638_RS08790
uniprot id: A0A5C0XRX1
uniprot id: Q8U072
names: Similarity
messages: Belongs to the phosphohexose mutase family.

186497:PFDSM3638 RS04735
gene id: 186497:PFDSM3638_RS04735
uniprot id: A0A5C0XQ20
uniprot id: Q8U2A0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

186497:PFDSM3638 RS02240
gene id: 186497:PFDSM3638_RS02240
uniprot id: A0A5C0XMS2
uniprot id: Q05907
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.
messages: Probably involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.

186497:PFDSM3638 RS07195
gene id: 186497:PFDSM3638_RS07195
uniprot id: Q8U0Z8
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: Inhibited by 0.1 mM Cu(2+).
messages: Probable subunit of a hydrogen-evolving hydrogenase that utilizes protons both as a substrate for hydrogen production and proton translocation. Acts by coupling the redox reaction via ferredoxin and iron-sulfur (Fe-S) clusters to proton translocation across the membrane, thereby conserving the redox energy in a proton gradient.
messages: The membrane-bound hydrogenase complex is composed of MbhK and MbhL, but may also contain MbhJ.
messages: The subunit composition of membrane-bound hydrogenase complex is currently unclear. It has been shown to be a heterodimer of MbhK and MbhL (PubMed:10852873). Other studies have shown it to contain MbhJ in addition to MbhK and MbhL (PubMed:11054105).

186497:PFDSM3638 RS08145
gene id: 186497:PFDSM3638_RS08145
uniprot id: A0A5C0XWQ8
uniprot id: Q8U0I2
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

186497:PFDSM3638 RS02615
gene id: 186497:PFDSM3638_RS02615
uniprot id: A0A5C0XP90
uniprot id: Q8U3E5
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

186497:PFDSM3638 RS05145
gene id: 186497:PFDSM3638_RS05145
uniprot id: A0A5C0XP04
uniprot id: Q8U230
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Cell membrane
messages: Membrane
messages: Potential transporter for phosphate.

186497:PFDSM3638 RS09205
gene id: 186497:PFDSM3638_RS09205
uniprot id: A0A5C0XQ78
uniprot id: Q8TZZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS03375
gene id: 186497:PFDSM3638_RS03375
uniprot id: A0A5C0XR96
uniprot id: Q8U302
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS05210
gene id: 186497:PFDSM3638_RS05210
uniprot id: A0A5C0XQ92
uniprot id: Q8U218
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

186497:PFDSM3638 RS09480
gene id: 186497:PFDSM3638_RS09480
uniprot id: A0A5C0XQB9
uniprot id: Q8TZV2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

186497:PFDSM3638 RS03335
gene id: 186497:PFDSM3638_RS03335
uniprot id: A0A5C0XN77
uniprot id: Q8U309
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

186497:PFDSM3638 RS04410
gene id: 186497:PFDSM3638_RS04410
uniprot id: A0A5C0XQK3
uniprot id: Q8U2G0
names: Caution
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS00730
gene id: 186497:PFDSM3638_RS00730
uniprot id: A0A5C0XN86
uniprot id: Q8U4D1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

186497:PFDSM3638 RS02295
gene id: 186497:PFDSM3638_RS02295
uniprot id: A0A5C0XQR2
uniprot id: Q8U3K5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

186497:PFDSM3638 RS08440
gene id: 186497:PFDSM3638_RS08440
uniprot id: A0A5C0XQG0
uniprot id: P58791
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

186497:PFDSM3638 RS08090
gene id: 186497:PFDSM3638_RS08090
uniprot id: A0A5C0XR49
uniprot id: Q8U0J1
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

186497:PFDSM3638 RS00900
gene id: 186497:PFDSM3638_RS00900
uniprot id: A0A5C0XM94
uniprot id: Q8U498
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

186497:PFDSM3638 RS00395
gene id: 186497:PFDSM3638_RS00395
uniprot id: A0A5C0XLM5
uniprot id: E7FHW3
names: Similarity
messages: Belongs to the glutaredoxin family.

186497:PFDSM3638 RS08300
gene id: 186497:PFDSM3638_RS08300
uniprot id: A0A5C0XR86
uniprot id: Q8U0F3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

186497:PFDSM3638 RS02530
gene id: 186497:PFDSM3638_RS02530
uniprot id: A0A5C0XNA3
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS01750
gene id: 186497:PFDSM3638_RS01750
uniprot id: A0A5C0XMY4
uniprot id: Q8U3S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

186497:PFDSM3638 RS09780
gene id: 186497:PFDSM3638_RS09780
uniprot id: A0A5C0XRY5
uniprot id: P58300
names: Function
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Involved in an abc transport system for maltotriose. Binds maltotriose much more tightly than maltose.

186497:PFDSM3638 RS05750
gene id: 186497:PFDSM3638_RS05750
uniprot id: A0A5C0XRA5
uniprot id: Q8U1R2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

186497:PFDSM3638 RS08430
gene id: 186497:PFDSM3638_RS08430
uniprot id: A0A5C0XRB8
uniprot id: P58880
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

186497:PFDSM3638 RS10045
gene id: 186497:PFDSM3638_RS10045
uniprot id: A0A5C0XS39
uniprot id: Q8TZK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

186497:PFDSM3638 RS01375
gene id: 186497:PFDSM3638_RS01375
uniprot id: A0A5C0XQA4
uniprot id: P72186
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Cell envelope
messages: Glycosylated.
messages: Has endopeptidase activity toward caseins, casein fragments including alpha-S1-casein and synthetic peptides.
messages: LWM pyrolysin seems to be produced by autoproteolytic activation of HMW pyrolysin.

186497:PFDSM3638 RS09315
gene id: 186497:PFDSM3638_RS09315
uniprot id: A0A5C0XQ95
uniprot id: Q8TZY0
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS08900
gene id: 186497:PFDSM3638_RS08900
uniprot id: A0A5C0XQ25
uniprot id: Q8U053
names: Similarity
messages: Belongs to the UPF0173 family.

186497:PFDSM3638 RS05270
gene id: 186497:PFDSM3638_RS05270
uniprot id: A0A5C0XNG0
uniprot id: Q8U207
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

186497:PFDSM3638 RS00985
gene id: 186497:PFDSM3638_RS00985
uniprot id: A0A5C0XQ43
uniprot id: Q8U483
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

186497:PFDSM3638 RS10180
gene id: 186497:PFDSM3638_RS10180
uniprot id: A0A5C0XQT7
uniprot id: P61877
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

186497:PFDSM3638 RS02195
gene id: 186497:PFDSM3638_RS02195
uniprot id: A0A5C0XP14
uniprot id: E7FHL5
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS08025
gene id: 186497:PFDSM3638_RS08025
uniprot id: A0A5C0XPN4
uniprot id: Q8U0K4
names: Similarity
messages: Belongs to the peptidase S49 family.

186497:PFDSM3638 RS01400
gene id: 186497:PFDSM3638_RS01400
uniprot id: A0A5C0XMU0
uniprot id: Q8U407
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

186497:PFDSM3638 RS02450
gene id: 186497:PFDSM3638_RS02450
uniprot id: A0A5C0XQU1
uniprot id: Q8U3H5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer (By similarity). Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with RNA polymerase in the absence of Tbp or DNA promoter (By similarity). Interacts both with the preinitiation and elongation complexes.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

186497:PFDSM3638 RS09990
gene id: 186497:PFDSM3638_RS09990
uniprot id: A0A5C0XR79
uniprot id: Q8TZL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

186497:PFDSM3638 RS03770
gene id: 186497:PFDSM3638_RS03770
uniprot id: A0A5C0XP32
uniprot id: Q8U2S5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

186497:PFDSM3638 RS04905
gene id: 186497:PFDSM3638_RS04905
uniprot id: A0A5C0XNS8
uniprot id: Q51799
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

186497:PFDSM3638 RS09155
gene id: 186497:PFDSM3638_RS09155
uniprot id: A0A5C0XQ70
uniprot id: Q8U009
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit (PubMed:23222135). Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

186497:PFDSM3638 RS05935
gene id: 186497:PFDSM3638_RS05935
uniprot id: A0A5C0XPD4
uniprot id: Q8U1M6
names: Similarity
messages: Belongs to the threonine synthase family.

186497:PFDSM3638 RS00835
gene id: 186497:PFDSM3638_RS00835
uniprot id: A0A5C0XNA4
uniprot id: Q8U4B0
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS02660
gene id: 186497:PFDSM3638_RS02660
uniprot id: Q8U3D6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetate CoA ligase alpha subunit family.
messages: Catalyzes the reversible formation of acetate and ATP from acetyl-CoA by using ADP and phosphate. Can use other substrates such as phenylacetyl-CoA, indoleacetyl-CoA and isobutyryl-CoA, but not succinyl-CoA. Seems to be involved primarily in the degradation of aryl-CoA esters to the corresponding acids. Participates in the conversion of acetyl-CoA to acetate and in the degradation of branched-chain amino acids via branched-chain-acyl-CoA esters.
messages: Heterotetramer of two alpha and two beta subunits.

186497:PFDSM3638 RS02200
gene id: 186497:PFDSM3638_RS02200
uniprot id: A0A5C0XM92
uniprot id: E7FI48
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

186497:PFDSM3638 RS04695
gene id: 186497:PFDSM3638_RS04695
uniprot id: A0A5C0XNQ0
uniprot id: Q8U2A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

186497:PFDSM3638 RS01945
gene id: 186497:PFDSM3638_RS01945
uniprot id: A0A5C0XTP0
uniprot id: Q8U3R2
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS09750
gene id: 186497:PFDSM3638_RS09750
uniprot id: A0A5C0XQL1
uniprot id: Q8TZQ5
names: Similarity
messages: Belongs to the UPF0273 family.

186497:PFDSM3638 RS05090
gene id: 186497:PFDSM3638_RS05090
uniprot id: Q8U242
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

186497:PFDSM3638 RS04110
gene id: 186497:PFDSM3638_RS04110
uniprot id: A0A5C0XRM6
uniprot id: Q8U2L3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL34 family.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS07945
gene id: 186497:PFDSM3638_RS07945
uniprot id: A0A5C0XWL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

186497:PFDSM3638 RS00705
gene id: 186497:PFDSM3638_RS00705
uniprot id: A0A5C0XLZ5
uniprot id: Q8U4D5
names: Similarity
messages: Belongs to the SAICAR synthetase family.

186497:PFDSM3638 RS08570
gene id: 186497:PFDSM3638_RS08570
uniprot id: A0A5C0XSH6
uniprot id: Q8U0B4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in both the arginine and lysine biosynthetic pathways.

186497:PFDSM3638 RS09000
gene id: 186497:PFDSM3638_RS09000
uniprot id: A0A5C0XQ42
uniprot id: Q9V2Z7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor. As a phosphoryl group donor, ADP can be replaced by GDP, ATP, and GTP to a limited extent.
messages: Cytoplasm
messages: Homotetramer.
messages: Inhibited by AMP and ATP.

186497:PFDSM3638 RS08670
gene id: 186497:PFDSM3638_RS08670
uniprot id: A0A5C0XRE1
uniprot id: Q8U094
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

186497:PFDSM3638 RS01785
gene id: 186497:PFDSM3638_RS01785
uniprot id: A0A5C0XN03
uniprot id: Q8U3T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

186497:PFDSM3638 RS01965
gene id: 186497:PFDSM3638_RS01965
uniprot id: A0A5C0XQL0
uniprot id: Q8U3Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

186497:PFDSM3638 RS01870
gene id: 186497:PFDSM3638_RS01870
uniprot id: A0A5C0XM53
uniprot id: Q8U3U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

186497:PFDSM3638 RS05730
gene id: 186497:PFDSM3638_RS05730
uniprot id: A0A5C0XSG9
uniprot id: Q8U1R6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

186497:PFDSM3638 RS06485
gene id: 186497:PFDSM3638_RS06485
uniprot id: A0A5C0XNX8
uniprot id: P62000
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

186497:PFDSM3638 RS04155
gene id: 186497:PFDSM3638_RS04155
uniprot id: A0A5C0XNM8
uniprot id: Q8U2K4
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS06925
gene id: 186497:PFDSM3638_RS06925
uniprot id: A0A5C0XPU1
uniprot id: Q8U150
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

186497:PFDSM3638 RS09120
gene id: 186497:PFDSM3638_RS09120
uniprot id: A0A5C0XRL4
uniprot id: Q9HH82
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL32 family.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS02500
gene id: 186497:PFDSM3638_RS02500
uniprot id: A0A5C0XMV8
uniprot id: Q8U3G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

186497:PFDSM3638 RS08420
gene id: 186497:PFDSM3638_RS08420
uniprot id: A0A5C0XRA6
uniprot id: Q8U0D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm

186497:PFDSM3638 RS07200
gene id: 186497:PFDSM3638_RS07200
uniprot id: Q8U0Z7
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Beta subunit of a hydrogen-evolving hydrogenase that utilizes protons both as a substrate for hydrogen production and proton translocation. Acts by coupling the redox reaction via ferredoxin and iron-sulfur (Fe-S) clusters to proton translocation across the membrane thereby conserving the redox energy in a proton gradient.
messages: Binds 1 nickel ion per mole of protein.
messages: Cell membrane
messages: Inhibited by 0.1 mM Cu(2+).
messages: The membrane-bound hydrogenase complex is composed of MbhK and MbhL, and may also contain MbhJ.
messages: The subunit composition of membrane-bound hydrogenase complex is currently unclear. It has been shown to be a heterodimer of MbhK and MbhL (PubMed:10852873). Other studies have shown it to contain MbhJ in addition to MbhK and MbhL (PubMed:11054105).
messages: There is conflicting N-terminal sequencing data for this protein. The mature protein may start from Ser-2 (PubMed:10852873) or Lys-3 (PubMed:11054105).

186497:PFDSM3638 RS08260
gene id: 186497:PFDSM3638_RS08260
uniprot id: A0A5C0XR92
uniprot id: Q8U0G0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

186497:PFDSM3638 RS01815
gene id: 186497:PFDSM3638_RS01815
uniprot id: A0A5C0XNV7
uniprot id: Q8U3T6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

186497:PFDSM3638 RS06405
gene id: 186497:PFDSM3638_RS06405
uniprot id: A0A5C0XVT9
uniprot id: Q9UWP5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS06155
gene id: 186497:PFDSM3638_RS06155
uniprot id: A0A5C0XQ61
uniprot id: Q8U1H9
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS07725
gene id: 186497:PFDSM3638_RS07725
uniprot id: A0A5C0XQY1
uniprot id: Q8TH23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

186497:PFDSM3638 RS08435
gene id: 186497:PFDSM3638_RS08435
uniprot id: A0A5C0XRB1
uniprot id: P58789
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

186497:PFDSM3638 RS00855
gene id: 186497:PFDSM3638_RS00855
uniprot id: A0A5C0XMM4
uniprot id: Q8U4A6
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.
messages: The intein interrupts the ATP-binding site.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation.

186497:PFDSM3638 RS09450
gene id: 186497:PFDSM3638_RS09450
uniprot id: A0A5C0XXI2
uniprot id: Q8TZV6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL33 family.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS03210
gene id: 186497:PFDSM3638_RS03210
uniprot id: A0A5C0XNB5
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

186497:PFDSM3638 RS06135
gene id: 186497:PFDSM3638_RS06135
uniprot id: A0A5C0XQ01
uniprot id: Q8U1I5
names: Function
names: Similarity
messages: Belongs to the UPF0330 family.
messages: Possibly the antitoxin component of a toxin-antitoxin (TA) module.
messages: Possibly the antitoxin component of a type II toxin-antitoxin (TA) system.

186497:PFDSM3638 RS07065
gene id: 186497:PFDSM3638_RS07065
uniprot id: A0A5C0XS14
uniprot id: Q8U123
names: Similarity
messages: Belongs to the threonine synthase family.

186497:PFDSM3638 RS00905
gene id: 186497:PFDSM3638_RS00905
uniprot id: A0A5C0XP35
uniprot id: Q8U497
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS05860
gene id: 186497:PFDSM3638_RS05860
uniprot id: A0A5C0XPV0
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

186497:PFDSM3638 RS01260
gene id: 186497:PFDSM3638_RS01260
uniprot id: A0A5C0XQ85
uniprot id: Q8U431
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

186497:PFDSM3638 RS06675
gene id: 186497:PFDSM3638_RS06675
uniprot id: A0A5C0XQF9
uniprot id: Q8U192
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

186497:PFDSM3638 RS09885
gene id: 186497:PFDSM3638_RS09885
uniprot id: A0A5C0XRZ7
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

186497:PFDSM3638 RS04970
gene id: 186497:PFDSM3638_RS04970
uniprot id: A0A5C0XQU9
uniprot id: O73947
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer which circularizes head-to-tail (head is a N-terminus, tail is at C-terminus) to form a toroid. RFC opens the toroid so it can load on DNA. Interacts with both Pol I (pol) and Pol II (polB-polC), with Hel308 (hjm) and with Hjc. Interaction with the C-terminal PIP-box of RfcL may stabilize the toroidal structure.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Unlike its eukaryotic paralog, loads on circular DNA without the replication factor C (RFC) clamp loader, although RFC greatly increases loading efficiency. Stimulates the ATPase activity of replication factor C (RFC) in the presence of ssDNA. Stimulates the helicase activity of Hel308 and may alter its substrate specificity.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

186497:PFDSM3638 RS05705
gene id: 186497:PFDSM3638_RS05705
uniprot id: A0A5C0XPS0
uniprot id: Q8U1S1
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS02495
gene id: 186497:PFDSM3638_RS02495
uniprot id: A0A5C0XNG4
uniprot id: Q8U3G8
names: Similarity
messages: Belongs to the arginase family.

186497:PFDSM3638 RS04705
gene id: 186497:PFDSM3638_RS04705
uniprot id: A0A5C0XP44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

186497:PFDSM3638 RS08795
gene id: 186497:PFDSM3638_RS08795
uniprot id: A0A5C0XQ10
uniprot id: Q8U071
names: Similarity
messages: Belongs to the thymidylate kinase family.

186497:PFDSM3638 RS08295
gene id: 186497:PFDSM3638_RS08295
uniprot id: A0A5C0XSM8
uniprot id: Q8U0F4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

186497:PFDSM3638 RS04875
gene id: 186497:PFDSM3638_RS04875
uniprot id: Q51805
names: Cofactor
names: Subunit
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

186497:PFDSM3638 RS08555
gene id: 186497:PFDSM3638_RS08555
uniprot id: A0A5C0XY65
uniprot id: Q8U0B7
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

186497:PFDSM3638 RS09090
gene id: 186497:PFDSM3638_RS09090
uniprot id: A0A5C0XQQ7
uniprot id: Q8U019
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved. The beta subunit (SecG) was lost during crystallization.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. Complements an E.coli temperature-sensitive secY mutation; deletion of the last 15 residues prevents complementation, which may indicate a role of this region in translocation.

186497:PFDSM3638 RS08325
gene id: 186497:PFDSM3638_RS08325
uniprot id: A0A5C0XTR6
uniprot id: Q8U0E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

186497:PFDSM3638 RS00950
gene id: 186497:PFDSM3638_RS00950
uniprot id: A0A5C0XM98
uniprot id: Q8U489
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

186497:PFDSM3638 RS03105
gene id: 186497:PFDSM3638_RS03105
uniprot id: A0A5C0XN34
uniprot id: Q8U354
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

186497:PFDSM3638 RS05280
gene id: 186497:PFDSM3638_RS05280
uniprot id: A0A5C0XR16
uniprot id: Q8U206
names: Similarity
messages: Belongs to the FUN14 family.

186497:PFDSM3638 RS06930
gene id: 186497:PFDSM3638_RS06930
uniprot id: A0A5C0XT31
uniprot id: Q8U149
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

186497:PFDSM3638 RS07790
gene id: 186497:PFDSM3638_RS07790
uniprot id: A0A5C0XTH2
uniprot id: Q8U0P5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS05065
gene id: 186497:PFDSM3638_RS05065
uniprot id: A0A5C0XND3
uniprot id: Q8U247
names: Similarity
messages: Belongs to the PstS family.

186497:PFDSM3638 RS05795
gene id: 186497:PFDSM3638_RS05795
uniprot id: A0A5C0XP87
uniprot id: Q8U1Q3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS07055
gene id: 186497:PFDSM3638_RS07055
uniprot id: A0A5C0XP88
uniprot id: Q8U125
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

186497:PFDSM3638 RS04275
gene id: 186497:PFDSM3638_RS04275
uniprot id: A0A5C0XRP9
uniprot id: Q8U2I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS00790
gene id: 186497:PFDSM3638_RS00790
uniprot id: A0A5C0XLS5
uniprot id: Q8U4B9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

186497:PFDSM3638 RS06650
gene id: 186497:PFDSM3638_RS06650
uniprot id: E7FHN9
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 [4Fe-4S] clusters.
messages: Cytoplasm
messages: Dimer of heterotetramer of alpha, beta, gamma and delta subunits. The nickel-containing alpha and delta subunits constitute the hydrogenase activity. The beta and gamma subunits (flavin-containing dimer) constitute the sulfur reductase activity.
messages: Part of a bifunctional enzyme complex that functions as a hydrogen-evolving hydrogenase with sulfur-reducing activity. May play a role in hydrogen cycling during fermentative growth. Activity exhibited with NAD in addition to NADPH. The beta and gamma subunits form the sulfur-reducing component that catalyzes the cytoplasmic production of hydrogen sulfide in the presence of elemental sulfur.

186497:PFDSM3638 RS01025
gene id: 186497:PFDSM3638_RS01025
uniprot id: A0A5C0XS24
uniprot id: Q8U476
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

186497:PFDSM3638 RS06195
gene id: 186497:PFDSM3638_RS06195
uniprot id: A0A5C0XVQ3
uniprot id: Q8U1H2
names: Similarity
messages: Belongs to the UPF0166 family.

186497:PFDSM3638 RS09375
gene id: 186497:PFDSM3638_RS09375
uniprot id: A0A5C0XS79
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

186497:PFDSM3638 RS05645
gene id: 186497:PFDSM3638_RS05645
uniprot id: A0A5C0XP57
uniprot id: Q8U1T3
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

186497:PFDSM3638 RS07750
gene id: 186497:PFDSM3638_RS07750
uniprot id: A0A5C0XQP6
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS06935
gene id: 186497:PFDSM3638_RS06935
uniprot id: A0A5C0XR37
uniprot id: Q8U148
names: Similarity
messages: Belongs to the UPF0179 family.

186497:PFDSM3638 RS00535
gene id: 186497:PFDSM3638_RS00535
uniprot id: A0A5C0XMF8
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

186497:PFDSM3638 RS07180
gene id: 186497:PFDSM3638_RS07180
uniprot id: A0A5C0XS36
uniprot id: Q8U101
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS07670
gene id: 186497:PFDSM3638_RS07670
uniprot id: A0A5C0XQX3
uniprot id: Q8U0R7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.
messages: Homotrimer and homohexamer.

186497:PFDSM3638 RS07070
gene id: 186497:PFDSM3638_RS07070
uniprot id: A0A5C0XQL7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS09560
gene id: 186497:PFDSM3638_RS09560
uniprot id: A0A5C0XRU8
uniprot id: Q8TZT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

186497:PFDSM3638 RS09130
gene id: 186497:PFDSM3638_RS09130
uniprot id: A0A5C0XRL9
uniprot id: Q8U014
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS01390
gene id: 186497:PFDSM3638_RS01390
uniprot id: A0A5C0XMH2
uniprot id: Q8U409
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

186497:PFDSM3638 RS03115
gene id: 186497:PFDSM3638_RS03115
uniprot id: A0A5C0XPF0
uniprot id: Q8U352
names: Similarity
messages: Belongs to the UPF0251 family.

186497:PFDSM3638 RS08455
gene id: 186497:PFDSM3638_RS08455
uniprot id: A0A5C0XPV4
uniprot id: Q8TH25
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

186497:PFDSM3638 RS06920
gene id: 186497:PFDSM3638_RS06920
uniprot id: A0A5C0XQJ2
uniprot id: Q8U151
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits. Forms a subcomplex with Rnp3 which stimulates the catalytic RNA.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. The RNA is catalytic, but its KM for pre-tRNA is 170-fold decreased in the presence of the 4 known protein subunits (Rnp1-4). The protein subunits also decrease the amount of Mg(2+) needed for activity.

186497:PFDSM3638 RS01005
gene id: 186497:PFDSM3638_RS01005
uniprot id: A0A5C0XMA4
uniprot id: P61875
names: Activity Regulation
names: Biotechnology
names: Function
names: Similarity
names: Subunit
messages: An 11-mer corresponding to the PIP-box of RfcL inhibits DNA synthesis.
messages: Because Pfu DNA polymerase exhibits the lowest error rate of any thermostable DNA polymerase studied, it is routinely used for PCR. It is sold by a number of companies including Promega, Stratagene and ThermoScientific. Various mutations to improve its abilities have been incorporated.
messages: Belongs to the DNA polymerase type-B family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity.
messages: Monomer.

186497:PFDSM3638 RS07140
gene id: 186497:PFDSM3638_RS07140
uniprot id: A0A5C0XW72
uniprot id: Q8U109
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

186497:PFDSM3638 RS09945
gene id: 186497:PFDSM3638_RS09945
uniprot id: A0A5C0XUK2
uniprot id: Q8TZM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

186497:PFDSM3638 RS01485
gene id: 186497:PFDSM3638_RS01485
uniprot id: A0A5C0XNK7
uniprot id: Q8U3Z2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

186497:PFDSM3638 RS09280
gene id: 186497:PFDSM3638_RS09280
uniprot id: A0A5C0XUY8
uniprot id: Q8TZY6
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS05220
gene id: 186497:PFDSM3638_RS05220
uniprot id: A0A5C0XNX9
uniprot id: Q8U217
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL21 family.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS01225
gene id: 186497:PFDSM3638_RS01225
uniprot id: A0A5C0XME2
uniprot id: Q8U438
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

186497:PFDSM3638 RS03790
gene id: 186497:PFDSM3638_RS03790
uniprot id: A0A5C0XRF5
uniprot id: Q8U2S1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

186497:PFDSM3638 RS06440
gene id: 186497:PFDSM3638_RS06440
uniprot id: A0A5C0XPR0
uniprot id: E7FH90
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

186497:PFDSM3638 RS00935
gene id: 186497:PFDSM3638_RS00935
uniprot id: A0A5C0XQ35
uniprot id: Q8U492
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

186497:PFDSM3638 RS01765
gene id: 186497:PFDSM3638_RS01765
uniprot id: A0A5C0XNU6
uniprot id: Q8U3S6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL39 family.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS04075
gene id: 186497:PFDSM3638_RS04075
uniprot id: A0A5C0XNU3
uniprot id: Q8U2L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

186497:PFDSM3638 RS02710
gene id: 186497:PFDSM3638_RS02710
uniprot id: A0A5C0XNP6
uniprot id: Q8U3C9
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: RNA-binding protein that probably controls the regulation of its own mRNA.

186497:PFDSM3638 RS10070
gene id: 186497:PFDSM3638_RS10070
uniprot id: A0A5C0XQR8
uniprot id: Q8TZJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit (PubMed:23222135). Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

186497:PFDSM3638 RS06215
gene id: 186497:PFDSM3638_RS06215
uniprot id: A0A5C0XSQ8
uniprot id: Q8U1G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

186497:PFDSM3638 RS06420
gene id: 186497:PFDSM3638_RS06420
uniprot id: A0A5C0XPK3
uniprot id: P24297
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

186497:PFDSM3638 RS00500
gene id: 186497:PFDSM3638_RS00500
uniprot id: A0A5C0XN59
uniprot id: Q8U4H3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

186497:PFDSM3638 RS02985
gene id: 186497:PFDSM3638_RS02985
uniprot id: A0A5C0XU69
uniprot id: Q51742
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Homododecamer (tetramer of trimers).
messages: Inhibited by the bisubstrate delta-N-phosphonoacetyl-L-ornithine (PALO).
messages: It interacts physically with carbamoyl-phosphate synthetase (CKase), forming a channeling cluster for carbamoyl phosphate. This prevents the thermodenaturation of carbamoyl phosphate, an extremely thermolabile and potentially toxic metabolic intermediate (PubMed:9501170).
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis.
messages: The monomer folds into two domains of similar size. The N-terminal domain is the carbamoylphosphate-binding domain; ornithine binds to the C-terminal domain.

186497:PFDSM3638 RS00330
gene id: 186497:PFDSM3638_RS00330
uniprot id: A0A5C0XPT2
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

186497:PFDSM3638 RS06330
gene id: 186497:PFDSM3638_RS06330
uniprot id: A0A5C0XPN3
uniprot id: Q8U1E3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

186497:PFDSM3638 RS00710
gene id: 186497:PFDSM3638_RS00710
uniprot id: A0A5C0XRP6
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

186497:PFDSM3638 RS09125
gene id: 186497:PFDSM3638_RS09125
uniprot id: A0A5C0XXD2
uniprot id: Q8U015
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

186497:PFDSM3638 RS08500
gene id: 186497:PFDSM3638_RS08500
uniprot id: A0A5C0XTU5
uniprot id: Q8U0C6
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

186497:PFDSM3638 RS08350
gene id: 186497:PFDSM3638_RS08350
uniprot id: A0A5C0XSP2
uniprot id: Q8U0E5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS06175
gene id: 186497:PFDSM3638_RS06175
uniprot id: A0A5C0XNR7
uniprot id: Q8U1H6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

186497:PFDSM3638 RS09770
gene id: 186497:PFDSM3638_RS09770
uniprot id: A0A5C0XXN7
uniprot id: Q8TZQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

186497:PFDSM3638 RS08375
gene id: 186497:PFDSM3638_RS08375
uniprot id: A0A5C0XRA2
uniprot id: Q8U0E2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit (PubMed:23222135). Forms a loose heterodimer with protein S19 (By similarity). Forms two bridges to the 50S subunit in the 70S ribosome (By similarity).
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

186497:PFDSM3638 RS08615
gene id: 186497:PFDSM3638_RS08615
uniprot id: A0A5C0XRE3
uniprot id: Q8U0A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

186497:PFDSM3638 RS00225
gene id: 186497:PFDSM3638_RS00225
uniprot id: A0A5C0XN18
uniprot id: Q8U4M1
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

186497:PFDSM3638 RS02655
gene id: 186497:PFDSM3638_RS02655
uniprot id: A0A5C0XMX3
uniprot id: Q8U3D7
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS00145
gene id: 186497:PFDSM3638_RS00145
uniprot id: A0A5C0XMA6
uniprot id: Q8U4N7
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS06750
gene id: 186497:PFDSM3638_RS06750
uniprot id: A0A5C0XT04
uniprot id: Q8U178
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

186497:PFDSM3638 RS10530
gene id: 186497:PFDSM3638_RS10530
uniprot id: A0A5C0XSC5
uniprot id: Q8U4Q8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS02965
gene id: 186497:PFDSM3638_RS02965
uniprot id: A0A5C0XML2
uniprot id: Q8U381
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. MPGP family.
messages: Cytoplasm
messages: Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG).

186497:PFDSM3638 RS01220
gene id: 186497:PFDSM3638_RS01220
uniprot id: A0A5C0XLW1
uniprot id: Q8U439
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

186497:PFDSM3638 RS07965
gene id: 186497:PFDSM3638_RS07965
uniprot id: A0A5C0XTK1
uniprot id: Q8U0L6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

186497:PFDSM3638 RS06290
gene id: 186497:PFDSM3638_RS06290
uniprot id: A0A5C0XQ87
uniprot id: Q8U1F1
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS07860
gene id: 186497:PFDSM3638_RS07860
uniprot id: A0A5C0XPK7
uniprot id: Q8U0N3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

186497:PFDSM3638 RS07740
gene id: 186497:PFDSM3638_RS07740
uniprot id: A0A5C0XRG4
uniprot id: Q8U0Q4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

186497:PFDSM3638 RS09505
gene id: 186497:PFDSM3638_RS09505
uniprot id: A0A5C0XRT8
uniprot id: E7FI46
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

186497:PFDSM3638 RS04980
gene id: 186497:PFDSM3638_RS04980
uniprot id: A0A5C0XV32
uniprot id: Q8U264
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

186497:PFDSM3638 RS02095
gene id: 186497:PFDSM3638_RS02095
uniprot id: A0A5C0XPM8
uniprot id: Q8U3N1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS07345
gene id: 186497:PFDSM3638_RS07345
uniprot id: A0A5C0XWB4
uniprot id: Q8U0X0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

186497:PFDSM3638 RS06890
gene id: 186497:PFDSM3638_RS06890
uniprot id: A0A5C0XQ50
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS07210
gene id: 186497:PFDSM3638_RS07210
uniprot id: A0A5C0XT76
uniprot id: Q8U0Z5
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS00770
gene id: 186497:PFDSM3638_RS00770
uniprot id: A0A5C0XM04
uniprot id: Q8U4C3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

186497:PFDSM3638 RS03010
gene id: 186497:PFDSM3638_RS03010
uniprot id: A0A5C0XPE0
uniprot id: Q8U373
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

186497:PFDSM3638 RS08460
gene id: 186497:PFDSM3638_RS08460
uniprot id: A0A5C0XR15
uniprot id: Q8U0D3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

186497:PFDSM3638 RS00030
gene id: 186497:PFDSM3638_RS00030
uniprot id: A0A5C0XLZ0
uniprot id: Q8U4Q7
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activity increases in the presence of Mg(2+) (PubMed:28978920). RNA-binding is heat stable (PubMed:12614195).
messages: Belongs to the FAU-1 family.
messages: Mainly homotrimer, but may form homohexamer, and homononamer.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Preferentially cleaves UA sequences in the 5' precursor region of 5S rRNA (PubMed:28978920). Binds to RNA in loop regions with AU-rich sequences. Binds to the consensus sequence GGC(U/A)(U/A)U(U/C) in vitro (PubMed:12614195).

186497:PFDSM3638 RS00505
gene id: 186497:PFDSM3638_RS00505
uniprot id: A0A5C0XLN9
uniprot id: Q8U4H2
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS09760
gene id: 186497:PFDSM3638_RS09760
uniprot id: A0A5C0XT98
uniprot id: Q8TZQ3
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS00890
gene id: 186497:PFDSM3638_RS00890
uniprot id: A0A5C0XNB1
uniprot id: Q8U4A0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

186497:PFDSM3638 RS01495
gene id: 186497:PFDSM3638_RS01495
uniprot id: A0A5C0XM00
uniprot id: Q8U3Z1
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS02125
gene id: 186497:PFDSM3638_RS02125
uniprot id: A0A5C0XML0
uniprot id: Q8U3M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

186497:PFDSM3638 RS09045
gene id: 186497:PFDSM3638_RS09045
uniprot id: A0A5C0XS21
uniprot id: Q8U027
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

186497:PFDSM3638 RS05380
gene id: 186497:PFDSM3638_RS05380
uniprot id: A0A5C0XR38
uniprot id: Q8U1Y5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS02675
gene id: 186497:PFDSM3638_RS02675
uniprot id: A0A5C0XMH5
uniprot id: Q8U3D3
names: Function
names: Similarity
messages: Belongs to the Tfx family.
messages: Putative transcriptional regulator.

186497:PFDSM3638 RS08015
gene id: 186497:PFDSM3638_RS08015
uniprot id: A0A5C0XTL2
uniprot id: Q8U0K6
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

186497:PFDSM3638 RS06065
gene id: 186497:PFDSM3638_RS06065
uniprot id: A0A5C0XPZ0
uniprot id: E7FHC0
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

186497:PFDSM3638 RS06790
gene id: 186497:PFDSM3638_RS06790
uniprot id: A0A5C0XQH8
uniprot id: Q8U170
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

186497:PFDSM3638 RS02385
gene id: 186497:PFDSM3638_RS02385
uniprot id: A0A5C0XNL3
uniprot id: Q3HUR2
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

186497:PFDSM3638 RS10140
gene id: 186497:PFDSM3638_RS10140
uniprot id: A0A5C0XTG2
uniprot id: Q8TZI8
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

186497:PFDSM3638 RS06630
gene id: 186497:PFDSM3638_RS06630
uniprot id: A0A5C0XQH5
uniprot id: Q8U197
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS02730
gene id: 186497:PFDSM3638_RS02730
uniprot id: A0A5C0XQY6
uniprot id: Q8U3C7
names: Similarity
messages: Belongs to the MoaD family.

186497:PFDSM3638 RS08600
gene id: 186497:PFDSM3638_RS08600
uniprot id: A0A5C0XSS4
uniprot id: Q8U0A8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

186497:PFDSM3638 RS07595
gene id: 186497:PFDSM3638_RS07595
uniprot id: E7FHX4
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. Cleaves both mobile and immobile junctions. Binds 4-way junction DNA, a synthetic Hj, binding is not competed by dsDNA.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Cleavage inhibited by RadB in the absence (but not presence) of ATP.
messages: Divalent cations, Mg(2+) has higher activity than Mn(2+).
messages: Homodimer. Probably interacts with PCNA and RadB.

186497:PFDSM3638 RS08545
gene id: 186497:PFDSM3638_RS08545
uniprot id: A0A5C0XWY1
uniprot id: Q8U0B9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

186497:PFDSM3638 RS07615
gene id: 186497:PFDSM3638_RS07615
uniprot id: A0A5C0XQ47
uniprot id: Q8U0S7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

186497:PFDSM3638 RS03430
gene id: 186497:PFDSM3638_RS03430
uniprot id: A0A5C0XPJ8
uniprot id: Q8U2Z1
names: Similarity
messages: Belongs to the TFIIB family.

186497:PFDSM3638 RS05610
gene id: 186497:PFDSM3638_RS05610
uniprot id: A0A5C0XVF0
uniprot id: Q8U1U0
names: Subcellular Location Annotation
messages: Cytoplasm

186497:PFDSM3638 RS01150
gene id: 186497:PFDSM3638_RS01150
uniprot id: A0A5C0XM52
uniprot id: Q8U453
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

186497:PFDSM3638 RS00715
gene id: 186497:PFDSM3638_RS00715
uniprot id: A0A5C0XQ00
uniprot id: Q8U4D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

186497:PFDSM3638 RS02960
gene id: 186497:PFDSM3638_RS02960
uniprot id: A0A5C0XPD5
uniprot id: Q8U382
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

186497:PFDSM3638 RS00215
gene id: 186497:PFDSM3638_RS00215
uniprot id: A0A5C0XLQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

186497:PFDSM3638 RS08165
gene id: 186497:PFDSM3638_RS08165
uniprot id: A0A5C0XTN6
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

186497:PFDSM3638 RS00075
gene id: 186497:PFDSM3638_RS00075
uniprot id: A0A5C0XLJ0
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

186497:PFDSM3638 RS08180
gene id: 186497:PFDSM3638_RS08180
uniprot id: A0A5C0XPR2
uniprot id: Q8U0H6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4 protein subunits. Forms a subcomplex with Rnp1 which stimulates the catalytic RNA.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. The RNA is catalytic, but its KM for pre-tRNA is 170-fold decreased in the presence of the 4 known protein subunits (Rnp1-4). The protein subunits also decrease the amount of Mg(2+) needed for activity.

186497:PFDSM3638 RS05720
gene id: 186497:PFDSM3638_RS05720
uniprot id: A0A5C0XPZ1
uniprot id: Q8U1R8
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity).
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The intein interrupts the GTP-binding site.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

186497:PFDSM3638 RS02810
gene id: 186497:PFDSM3638_RS02810
uniprot id: A0A5C0XU34
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

186497:PFDSM3638 RS07000
gene id: 186497:PFDSM3638_RS07000
uniprot id: A0A5C0XQ72
uniprot id: Q8U136
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

186497:PFDSM3638 RS05710
gene id: 186497:PFDSM3638_RS05710
uniprot id: A0A5C0XVH0
uniprot id: Q8U1S0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS05315
gene id: 186497:PFDSM3638_RS05315
uniprot id: A0A5C0XQB1
uniprot id: Q8U1Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

186497:PFDSM3638 RS01460
gene id: 186497:PFDSM3638_RS01460
uniprot id: A0A5C0XN74
uniprot id: Q8U3Z6
names: Similarity
messages: Belongs to the UPF0284 family.

186497:PFDSM3638 RS09025
gene id: 186497:PFDSM3638_RS09025
uniprot id: A0A5C0XRK5
uniprot id: Q8U031
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

186497:PFDSM3638 RS02970
gene id: 186497:PFDSM3638_RS02970
uniprot id: Q8U380
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Cytoplasm
messages: Transfers a mannosyl group from GDP-mannose to phosphoglycerate to form mannosyl-3-phosphoglycerate (MPG).

186497:PFDSM3638 RS01845
gene id: 186497:PFDSM3638_RS01845
uniprot id: A0A5C0XND6
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

186497:PFDSM3638 RS05465
gene id: 186497:PFDSM3638_RS05465
uniprot id: A0A5C0XP56
uniprot id: Q8U1W7
names: Similarity
messages: Belongs to the PDCD5 family.

186497:PFDSM3638 RS09145
gene id: 186497:PFDSM3638_RS09145
uniprot id: A0A5C0XU55
uniprot id: Q8U011
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS4 family.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS09390
gene id: 186497:PFDSM3638_RS09390
uniprot id: A0A5C0XT45
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

186497:PFDSM3638 RS06510
gene id: 186497:PFDSM3638_RS06510
uniprot id: A0A5C0XVW2
uniprot id: Q8U1C1
names: Similarity
messages: Belongs to the UPF0248 family.

186497:PFDSM3638 RS09430
gene id: 186497:PFDSM3638_RS09430
uniprot id: A0A5C0XQB0
uniprot id: Q8TZV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

186497:PFDSM3638 RS06370
gene id: 186497:PFDSM3638_RS06370
uniprot id: A0A5C0XST5
uniprot id: Q8U1D7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

186497:PFDSM3638 RS03390
gene id: 186497:PFDSM3638_RS03390
uniprot id: A0A5C0XN85
uniprot id: O73946
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: Constitutively expressed (at protein level).
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. Unwinds the lagging strand from forked DNA structures in a 3'-5' direction. PCNA, the DNA polymerase sliding clamp subunit, stimulates the helicase activity, and may alter substrate specificity. Unwinds branched DNA (Holliday junctions) in an ATP-dependent fashion; ss- and dsDNA stimulate ATPase to the greatest extent, although it preferentially binds DNA with a single-stranded region. Processes a RecA-mediated recombination intermediate between gapped circular and homologous linear dsDNA.
messages: Divalent cations, Mg(2+) and Zn(2+) are best.
messages: Monomer.
messages: Monomer. Interacts with PCNA.

186497:PFDSM3638 RS02235
gene id: 186497:PFDSM3638_RS02235
uniprot id: A0A5C0XNC7
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS03405
gene id: 186497:PFDSM3638_RS03405
uniprot id: A0A5C0XUF1
uniprot id: Q8U2Z8
names: Similarity
messages: Belongs to the UPF0047 family.

186497:PFDSM3638 RS00795
gene id: 186497:PFDSM3638_RS00795
uniprot id: A0A5C0XM83
uniprot id: Q8U4B8
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS08680
gene id: 186497:PFDSM3638_RS08680
uniprot id: A0A5C0XTX1
uniprot id: Q8U092
names: Similarity
messages: Belongs to the TrpF family.

186497:PFDSM3638 RS01205
gene id: 186497:PFDSM3638_RS01205
uniprot id: A0A5C0XM57
uniprot id: Q8U442
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: May be present in 2 copies per 70S ribosome (PubMed:23222135). Part of the 30S ribosomal subunit, where it binds 16S rRNA at its canonical site at the bse of the body, as well as a possible second 50S binding site near 23S rRNA helix 45 (PubMed:23222135).

186497:PFDSM3638 RS09160
gene id: 186497:PFDSM3638_RS09160
uniprot id: A0A5C0XRD3
uniprot id: Q8U008
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS09880
gene id: 186497:PFDSM3638_RS09880
uniprot id: A0A5C0XS09
uniprot id: P58314
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by citrate.
messages: Belongs to the DeoC/FbaB aldolase family.
messages: Cytoplasm
messages: Homooctamer.

186497:PFDSM3638 RS02270
gene id: 186497:PFDSM3638_RS02270
uniprot id: A0A5C0XN72
uniprot id: Q8U3L0
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M32 family.
messages: Binds 1 cobalt ion per subunit. Can also utilize Mn(2+) (in vitro). Is not active with zinc ions.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues, but not Pro, Gly, Asp and Glu.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.
messages: EDTA and DTT reversibly abolish carboxypeptidase activity.
messages: Homodimer.

186497:PFDSM3638 RS02470
gene id: 186497:PFDSM3638_RS02470
uniprot id: A0A5C0XMW2
uniprot id: O73954
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Binds two Mg(2+) per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.
messages: When a topoisomerase transiently breaks a DNA backbone bond, it simultaneously forms a protein-DNA link, in which a tyrosyl oxygen in the enzyme is joined to a DNA phosphorus at one end of the enzyme-severed DNA strand.

186497:PFDSM3638 RS04490
gene id: 186497:PFDSM3638_RS04490
uniprot id: A0A5C0XPH9
uniprot id: Q8U2E4
names: Activity Regulation
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cytoplasm
messages: Heterotetramer of alpha, beta, gamma and delta subunits. The nickel-containing alpha and delta subunits constitute the hydrogenase activity. The beta and gamma subunits (flavin-containing dimer) constitute the sulfur reductase activity.
messages: Part of a bifunctional enzyme complex that functions as an NADPH-dependent hydrogen-evolving hydrogenase with sulfur reducing activity. May play a role in hydrogen cycling during fermentative growth. Activity not exhibited with NAD. The beta and gamma subunits form the sulfur reducing component that catalyzes the cytoplasmic production of hydrogen sulfide in the presence of elemental sulfur. Not active in the presence of sodium sulfate, sodium sulfite, sodium thiosulfate or cysteine.
messages: Stimulated by rubredoxin at pH 7.6 but not ferredoxin.

186497:PFDSM3638 RS08770
gene id: 186497:PFDSM3638_RS08770
uniprot id: A0A5C0XRG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

186497:PFDSM3638 RS02120
gene id: 186497:PFDSM3638_RS02120
uniprot id: A0A5C0XNA7
uniprot id: Q8U3M7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS08445
gene id: 186497:PFDSM3638_RS08445
uniprot id: A0A5C0XTT5
uniprot id: P58800
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

186497:PFDSM3638 RS00650
gene id: 186497:PFDSM3638_RS00650
uniprot id: Q8U4E6
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity (By similarity).
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer (By similarity).

186497:PFDSM3638 RS08520
gene id: 186497:PFDSM3638_RS08520
uniprot id: A0A5C0XPW5
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

186497:PFDSM3638 RS05665
gene id: 186497:PFDSM3638_RS05665
uniprot id: Q8U1S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CRISPR system Cmr4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), formerly called psiRNA (prokaryotic silencing) in this organism. Part of the Cmr ribonucleoprotein complex which has divalent cation-dependent endoribonuclease activity specific for ssRNA complementary to the crRNA (target RNA), generating 5' hydroxy- and 3' phosphate or 2'-3' cyclic phosphate termini. This is probably the subunit that cleaves the target RNA (PubMed:25280103). Cmr complex does not cleave ssDNA complementary to the crRNA. Cleavage of target RNA is guided by the crRNA; substrate cleavage occurs a fixed distance (14 nt) from the 3' end of the crRNA. In vitro reconstitution shows Cmr1-2 and Cmr5 are not absolutely necessary for target cleavage (PubMed:19945378).
messages: Cytoplasm
messages: Forms oligomers in isolation (PubMed:23370277). Part of the type III-B Cmr ribonucleoprotein (RNP) complex, an elongated RNP with Cmr2 and Cmr3 as the base, with Cmr4 and Cmr5 forming a helical core along the mature crRNA (39 or 45 nt in length), while the complex is capped by Cmr6 and Cmr1. The 5' end of the crRNA is bound to Cmr2 and Cmr3, while Cmr6 and a Cmr1 subunit (Cmr1-1 or Cmr1-2) cap the 3' end of the crRNA. The target RNA lies anti-parallel to the crRNA, with its 5' end near Cmr1 and Cmr6 and its 3' end near Cmr2 and Cmr3; major target RNA cleavage occurs nears the junction of Cmr1/Cmr6 and Cmr4/Cmr5, with minor cleavage occurring at 6 nt intervals which coincide with the proposed spacing of Cmr4 subunits (PubMed:24119404, PubMed:25280103). Interacts with Cmr5 (PubMed:23370277). Interacts with Cmr2, Cmr3, Cmr5 and Cmr6 (PubMed:25280103).

186497:PFDSM3638 RS09550
gene id: 186497:PFDSM3638_RS09550
uniprot id: A0A5C0XRS9
uniprot id: Q8TZU1
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS05050
gene id: 186497:PFDSM3638_RS05050
uniprot id: A0A5C0XNY7
uniprot id: Q8U250
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

186497:PFDSM3638 RS09175
gene id: 186497:PFDSM3638_RS09175
uniprot id: A0A5C0XXE0
uniprot id: Q8U005
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS06480
gene id: 186497:PFDSM3638_RS06480
uniprot id: A0A5C0XQV7
uniprot id: P58833
names: Similarity
messages: Belongs to the UPF0200 family.

186497:PFDSM3638 RS10015
gene id: 186497:PFDSM3638_RS10015
uniprot id: A0A5C0XRS5
uniprot id: P58852
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

186497:PFDSM3638 RS06850
gene id: 186497:PFDSM3638_RS06850
uniprot id: A0A5C0XQI1
uniprot id: Q8U159
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS28 family.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS08715
gene id: 186497:PFDSM3638_RS08715
uniprot id: A0A5C0XRF6
uniprot id: Q8U085
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS05760
gene id: 186497:PFDSM3638_RS05760
uniprot id: A0A5C0XVI0
uniprot id: Q8U1R0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

186497:PFDSM3638 RS03095
gene id: 186497:PFDSM3638_RS03095
uniprot id: A0A5C0XNT5
uniprot id: Q8U356
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

186497:PFDSM3638 RS06275
gene id: 186497:PFDSM3638_RS06275
uniprot id: A0A5C0XNT8
uniprot id: Q8U1F5
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

186497:PFDSM3638 RS02405
gene id: 186497:PFDSM3638_RS02405
uniprot id: A0A5C0XP52
uniprot id: Q8U3I4
names: Similarity
messages: Belongs to the MCM family.

186497:PFDSM3638 RS04590
gene id: 186497:PFDSM3638_RS04590
uniprot id: A0A5C0XP28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

186497:PFDSM3638 RS08655
gene id: 186497:PFDSM3638_RS08655
uniprot id: A0A5C0XRD8
uniprot id: Q8U097
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

186497:PFDSM3638 RS09475
gene id: 186497:PFDSM3638_RS09475
uniprot id: A0A5C0XS98
uniprot id: Q8TZV3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

186497:PFDSM3638 RS09365
gene id: 186497:PFDSM3638_RS09365
uniprot id: A0A5C0XU96
uniprot id: Q8TZX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

186497:PFDSM3638 RS04750
gene id: 186497:PFDSM3638_RS04750
uniprot id: A0A5C0XQQ9
uniprot id: Q8U297
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS08035
gene id: 186497:PFDSM3638_RS08035
uniprot id: A0A5C0XSI0
uniprot id: Q8U0K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

186497:PFDSM3638 RS08920
gene id: 186497:PFDSM3638_RS08920
uniprot id: A0A5C0XX43
uniprot id: Q8U049
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

186497:PFDSM3638 RS04895
gene id: 186497:PFDSM3638_RS04895
uniprot id: A0A5C0XQ45
uniprot id: Q51801
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

186497:PFDSM3638 RS01950
gene id: 186497:PFDSM3638_RS01950
uniprot id: A0A5C0XNF4
uniprot id: Q8U3R1
names: Subunit
messages: Homodimer.

186497:PFDSM3638 RS00390
gene id: 186497:PFDSM3638_RS00390
uniprot id: A0A5C0XN43
uniprot id: Q8U4J3
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of three to four small subunits (RfcS) and one to two large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA.
messages: The intein interrupts the potential ATP-binding site.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

186497:PFDSM3638 RS01510
gene id: 186497:PFDSM3638_RS01510
uniprot id: A0A5C0XMV4
uniprot id: Q9V2Z6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ADP-dependent glucokinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate.
messages: Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate. Can also use CDP as the phosphoryl group donor and D-1,5-anhydroglucitol as the phosphoryl group acceptor.
messages: Cytoplasm
messages: Homodimer.

186497:PFDSM3638 RS07325
gene id: 186497:PFDSM3638_RS07325
uniprot id: A0A5C0XPD2
names: Similarity
messages: Belongs to the glutaredoxin family.

186497:PFDSM3638 RS10170
gene id: 186497:PFDSM3638_RS10170
uniprot id: A0A5C0XUN8
uniprot id: Q8TZI2
names: Function
messages: Probably involved in the biogenesis of the ribosome.

186497:PFDSM3638 RS10260
gene id: 186497:PFDSM3638_RS10260
uniprot id: A0A5C0XRJ7
uniprot id: Q8TZG2
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS09975
gene id: 186497:PFDSM3638_RS09975
uniprot id: A0A5C0XXS6
uniprot id: Q8TZL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

186497:PFDSM3638 RS06855
gene id: 186497:PFDSM3638_RS06855
uniprot id: A0A5C0XPT3
uniprot id: Q8U158
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit (PubMed:23222135). Forms a cluster with proteins L3 and L14.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

186497:PFDSM3638 RS04555
gene id: 186497:PFDSM3638_RS04555
uniprot id: A0A5C0XPE6
uniprot id: Q8U2D6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

186497:PFDSM3638 RS08270
gene id: 186497:PFDSM3638_RS08270
uniprot id: A0A5C0XQD8
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

186497:PFDSM3638 RS00175
gene id: 186497:PFDSM3638_RS00175
uniprot id: A0A5C0XN09
uniprot id: Q8U4N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

186497:PFDSM3638 RS01125
gene id: 186497:PFDSM3638_RS01125
uniprot id: A0A5C0XP73
uniprot id: Q8U458
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

186497:PFDSM3638 RS00050
gene id: 186497:PFDSM3638_RS00050
uniprot id: A0A5C0XMG0
uniprot id: Q8TH22
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

186497:PFDSM3638 RS02565
gene id: 186497:PFDSM3638_RS02565
uniprot id: A0A5C0XP80
uniprot id: Q8U3F5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

186497:PFDSM3638 RS01780
gene id: 186497:PFDSM3638_RS01780
uniprot id: A0A5C0XPH3
uniprot id: Q8U3S9
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit (PubMed:23222135). Binds 23S rRNA.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

186497:PFDSM3638 RS05740
gene id: 186497:PFDSM3638_RS05740
uniprot id: A0A5C0XNM6
uniprot id: Q8U1R4
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

186497:PFDSM3638 RS03595
gene id: 186497:PFDSM3638_RS03595
uniprot id: A0A5C0XQA1
uniprot id: Q8U2V6
names: Subcellular Location Annotation
messages: Cytoplasm

186497:PFDSM3638 RS00245
gene id: 186497:PFDSM3638_RS00245
uniprot id: A0A5C0XMC8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the N-terminal section; belongs to the DHBP synthase family.

186497:PFDSM3638 RS05535
gene id: 186497:PFDSM3638_RS05535
uniprot id: A0A5C0XP37
uniprot id: Q8U1V4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

186497:PFDSM3638 RS04365
gene id: 186497:PFDSM3638_RS04365
uniprot id: A0A5C0XNY5
uniprot id: Q8U2H0
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS07110
gene id: 186497:PFDSM3638_RS07110
uniprot id: A0A5C0XP99
uniprot id: O93634
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

186497:PFDSM3638 RS02310
gene id: 186497:PFDSM3638_RS02310
uniprot id: A0A5C0XMB7
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

186497:PFDSM3638 RS01610
gene id: 186497:PFDSM3638_RS01610
uniprot id: A0A5C0XM17
uniprot id: Q8U3X1
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS04885
gene id: 186497:PFDSM3638_RS04885
uniprot id: A0A5C0XNW5
uniprot id: Q51803
names: Cofactor
names: Subunit
messages: Binds 2 [4Fe-4S] clusters.
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

186497:PFDSM3638 RS08565
gene id: 186497:PFDSM3638_RS08565
uniprot id: A0A5C0XQH3
uniprot id: Q8U0B5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS02515
gene id: 186497:PFDSM3638_RS02515
uniprot id: A0A5C0XMF5
uniprot id: Q8U3G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

186497:PFDSM3638 RS06185
gene id: 186497:PFDSM3638_RS06185
uniprot id: A0A5C0XRH2
uniprot id: Q8U1H4
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

186497:PFDSM3638 RS10395
gene id: 186497:PFDSM3638_RS10395
uniprot id: A0A5C0XTK4
uniprot id: Q8TZD9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS05060
gene id: 186497:PFDSM3638_RS05060
uniprot id: Q8U248
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily.
messages: Consists of an N-terminal THUMP domain fused to a catalytic Rossmann-fold MTase (RFM) domain.
messages: Cytoplasm
messages: Monomer in solution.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the methylation of the guanosine nucleotide at position 6 (m2G6) in tRNA(Phe).

186497:PFDSM3638 RS05820
gene id: 186497:PFDSM3638_RS05820
uniprot id: A0A5C0XQ49
uniprot id: Q8U1P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

186497:PFDSM3638 RS01420
gene id: 186497:PFDSM3638_RS01420
uniprot id: A0A5C0XM77
uniprot id: Q8U403
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

186497:PFDSM3638 RS07735
gene id: 186497:PFDSM3638_RS07735
uniprot id: A0A5C0XTG6
uniprot id: Q8U0Q5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS09725
gene id: 186497:PFDSM3638_RS09725
uniprot id: A0A5C0XRY0
uniprot id: O74036
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

186497:PFDSM3638 RS08075
gene id: 186497:PFDSM3638_RS08075
uniprot id: A0A5C0XPP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

186497:PFDSM3638 RS07905
gene id: 186497:PFDSM3638_RS07905
uniprot id: A0A5C0XRJ4
uniprot id: Q8U0M5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex (PubMed:21386817). An artificial construct of the RNAP clamp domain (including part of this protein) contacts transcription elongation factors Spt4 and Spt5 (PubMed:21386817).
messages: Part of the RNA polymerase complex.

186497:PFDSM3638 RS07960
gene id: 186497:PFDSM3638_RS07960
uniprot id: A0A5C0XQ91
uniprot id: Q8U0L7
names: Similarity
messages: Belongs to the SDO1/SBDS family.

186497:PFDSM3638 RS03385
gene id: 186497:PFDSM3638_RS03385
uniprot id: A0A5C0XMR3
uniprot id: P95474
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the carbamate kinase family.
messages: Carbamate kinase that plays a biosynthetic role in that it produces carbamoyl-phosphate.
messages: Cytoplasm
messages: Homodimer.

186497:PFDSM3638 RS07305
gene id: 186497:PFDSM3638_RS07305
uniprot id: A0A5C0XQR0
uniprot id: Q8U0X8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS07155
gene id: 186497:PFDSM3638_RS07155
uniprot id: A0A5C0XPX9
uniprot id: Q8U106
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS09605
gene id: 186497:PFDSM3638_RS09605
uniprot id: A0A5C0XT70
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

186497:PFDSM3638 RS09195
gene id: 186497:PFDSM3638_RS09195
uniprot id: A0A5C0XU65
uniprot id: Q8U001
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit (PubMed:23222135). Forms a bridge to the 30S subunit in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

186497:PFDSM3638 RS05385
gene id: 186497:PFDSM3638_RS05385
uniprot id: Q8U1Y4
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peptidase M67B family.
messages: Binds 1 zinc ion per subunit.
messages: Exists in two major states: monomer and homodimer. Both conformational states are catalytically active.
messages: Inhibited by EDTA in vitro.
messages: Metalloprotease that displays desampylase (DSAMP) activity, cleaving ubiquitin-like small archaeal modifier proteins (SAMP1, SAMP2 and SAMP3) from protein conjugates (isopeptide- and linear-linked). Thus, likely regulates sampylation and the pools of 'free' SAMP available for protein modification. In vitro, is also able to cleave non-physiological ubiquitin (Ub) substrates, such as 'Met1-', 'Lys48-', and 'Lys63'-linked Ub dimers (Ub2), and to remove Ub tags from diverse proteins.
messages: The disulfide bridge probably stabilizes the PfJAMM1 homodimer at the optimal growth temperature of the hyperthermophile.

186497:PFDSM3638 RS01250
gene id: 186497:PFDSM3638_RS01250
uniprot id: A0A5C0XMR0
uniprot id: Q8U433
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS00165
gene id: 186497:PFDSM3638_RS00165
uniprot id: A0A5C0XLP8
uniprot id: Q8U4N3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

186497:PFDSM3638 RS02330
gene id: 186497:PFDSM3638_RS02330
uniprot id: A0A5C0XTU8
uniprot id: Q8U3J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

186497:PFDSM3638 RS08425
gene id: 186497:PFDSM3638_RS08425
uniprot id: A0A5C0XWW1
uniprot id: O59626
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

186497:PFDSM3638 RS09950
gene id: 186497:PFDSM3638_RS09950
uniprot id: A0A5C0XSI6
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS10310
gene id: 186497:PFDSM3638_RS10310
uniprot id: A0A5C0XS69
uniprot id: Q8TZF3
names: Similarity
messages: Belongs to the UPF0215 family.

186497:PFDSM3638 RS07785
gene id: 186497:PFDSM3638_RS07785
uniprot id: E7FI45
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity is dependent on magnesium.
messages: Belongs to the acetate CoA ligase alpha subunit family.
messages: Catalyzes the reversible formation of acetate and ATP from acetyl-CoA by using ADP and phosphate. Can use other substrates such as isobutyryl-CoA, propionyl-CoA and butyryl-CoA, but not indoleacetyl-CoA, phenylacetyl-CoA or succinyl-CoA. Seems to be involved primarily in the conversion of acetyl-CoA to acetate. Participates in the degradation of branched-chain amino acids via branched-chain-acyl-CoA esters.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta subunits.

186497:PFDSM3638 RS02410
gene id: 186497:PFDSM3638_RS02410
uniprot id: A0A5C0XME1
uniprot id: Q8U3I3
names: Subcellular Location Annotation
messages: Nucleus

186497:PFDSM3638 RS02315
gene id: 186497:PFDSM3638_RS02315
uniprot id: A0A5C0XMU3
uniprot id: Q8U3K2
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Activity increased by 58%-93% in the presence of acetyl phosphate, 3-phosphoglycerate or 2,3-bisphosphoglycerate at 10 mM concentration. Inhibited by up to 25% in the presence of crotonaldehyde or formaldehyde at 10 mM concentration. Inhibited by up to 50% by sodium dithionate. 3.5-fold increase in activity observed by addition of potassium phosphate or sodium arsenate at 200 mM concentration. Activity enhanced by potassium chloride, sodium citrate or sodium sulfate at 200 mM concentration. Sensitive to oxygen.
messages: Belongs to the AOR/FOR family.
messages: Binds 1 W-bis(molybdopterin guanine dinucleotide) (W-bis-MGD) cofactor per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Glycolytic enzyme that acts in the place of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoglycerate kinase (PGK). Plays a role in anabolic gluconeogenesis.
messages: Monomer.
messages: Two zinc atoms per subunit with no known function have been observed.

186497:PFDSM3638 RS01810
gene id: 186497:PFDSM3638_RS01810
uniprot id: A0A5C0XQH7
uniprot id: Q8U3T5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

186497:PFDSM3638 RS00320
gene id: 186497:PFDSM3638_RS00320
uniprot id: A0A5C0XMB8
uniprot id: Q8U4K7
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

186497:PFDSM3638 RS01770
gene id: 186497:PFDSM3638_RS01770
uniprot id: A0A5C0XM44
uniprot id: Q8U3S7
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS05805
gene id: 186497:PFDSM3638_RS05805
uniprot id: A0A5C0XY47
uniprot id: Q8U1Q1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-64 and Arg-67) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

186497:PFDSM3638 RS07685
gene id: 186497:PFDSM3638_RS07685
uniprot id: A0A5C0XRF7
uniprot id: Q8U0R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

186497:PFDSM3638 RS07915
gene id: 186497:PFDSM3638_RS07915
uniprot id: A0A5C0XQS2
uniprot id: Q8U0M3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

186497:PFDSM3638 RS04690
gene id: 186497:PFDSM3638_RS04690
uniprot id: A0A5C0XN75
uniprot id: Q8U2A9
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP). To a lesser extent, can also use CTP, UTP, and GTP as the nucleotide triphosphate substrate.

186497:PFDSM3638 RS07260
gene id: 186497:PFDSM3638_RS07260
uniprot id: A0A5C0XPZ6
uniprot id: Q8U0Y7
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

186497:PFDSM3638 RS00540
gene id: 186497:PFDSM3638_RS00540
uniprot id: A0A5C0XLT8
uniprot id: Q8U4G5
names: Similarity
messages: Belongs to the UPF0146 family.

186497:PFDSM3638 RS06995
gene id: 186497:PFDSM3638_RS06995
uniprot id: A0A5C0XP78
uniprot id: Q8U137
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

186497:PFDSM3638 RS02715
gene id: 186497:PFDSM3638_RS02715
uniprot id: A0A5C0XNJ4
uniprot id: P56218
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

186497:PFDSM3638 RS05965
gene id: 186497:PFDSM3638_RS05965
uniprot id: A0A5C0XPX2
uniprot id: Q8U1M0
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the CoA-dependent reduction of elemental sulfur (S(0)) to produce hydrogen sulfide (PubMed:17449625, PubMed:24723088). Can use both NADPH and NADH, but shows a preference for NADPH (PubMed:24723088). May enable S(0) to be used, via sulfide, for iron-sulfur cluster synthesis by SipA (Probable). Also shows coenzyme A disulfide reductase (CoADR) activity with both NADH and NADPH (PubMed:15720393, PubMed:17449625). However, CoADR specific activity is about 20-fold lower than the sulfur reduction assay and CoADR activity appears to be an artifactual side reaction and is not thought to have any physiological relevance (PubMed:17449625). Also shows NAD(P)H oxidase activity with both NADH and NADPH (PubMed:24723088).
messages: Cytoplasm
messages: Deletion mutant does not exhibit an obvious phenotype and produces sulfide and acetate in amounts comparable to those produced by the parent strain.
messages: Homodimer.
messages: Up-regulated up to sevenfold by elemental sulfur addition.

186497:PFDSM3638 RS00860
gene id: 186497:PFDSM3638_RS00860
uniprot id: A0A5C0XST3
uniprot id: Q8U4A5
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

186497:PFDSM3638 RS06710
gene id: 186497:PFDSM3638_RS06710
uniprot id: A0A5C0XP20
uniprot id: Q8U185
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

186497:PFDSM3638 RS06680
gene id: 186497:PFDSM3638_RS06680
uniprot id: A0A5C0XVY9
uniprot id: Q8U191
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

186497:PFDSM3638 RS02110
gene id: 186497:PFDSM3638_RS02110
uniprot id: A0A5C0XNH6
uniprot id: Q8U3M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

186497:PFDSM3638 RS05150
gene id: 186497:PFDSM3638_RS05150
uniprot id: A0A5C0XS67
uniprot id: Q8U229
names: Similarity
messages: Belongs to the UPF0111 family.

186497:PFDSM3638 RS06270
gene id: 186497:PFDSM3638_RS06270
uniprot id: A0A5C0XQR7
uniprot id: Q8U1F6
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS02990
gene id: 186497:PFDSM3638_RS02990
uniprot id: A0A5C0XNS2
uniprot id: Q8U377
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

186497:PFDSM3638 RS01215
gene id: 186497:PFDSM3638_RS01215
uniprot id: A0A5C0XNG7
uniprot id: Q8U440
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Contains a N-terminal zinc-binding domain and a C-terminal NGN-binding domain.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

186497:PFDSM3638 RS08370
gene id: 186497:PFDSM3638_RS08370
uniprot id: A0A5C0XRB2
uniprot id: P61993
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit (PubMed:23222135). Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

186497:PFDSM3638 RS09650
gene id: 186497:PFDSM3638_RS09650
uniprot id: A0A5C0XQE7
uniprot id: Q8TZS3
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

186497:PFDSM3638 RS04280
gene id: 186497:PFDSM3638_RS04280
uniprot id: A0A5C0XPW4
uniprot id: Q8U2I1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines. It seems that P.furiosus has developed a specific enzyme (PF0853) for the metabolism of 6-oxo-purines, next to the canonical MTA phosphorylase PF0016.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

186497:PFDSM3638 RS02475
gene id: 186497:PFDSM3638_RS02475
uniprot id: A0A5C0XPU3
uniprot id: P95479
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Binds two Mg(2+) per subunit.
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

186497:PFDSM3638 RS04730
gene id: 186497:PFDSM3638_RS04730
uniprot id: A0A5C0XRX9
uniprot id: Q8U2A1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

186497:PFDSM3638 RS04865
gene id: 186497:PFDSM3638_RS04865
uniprot id: A0A5C0XP72
uniprot id: Q8U276
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

186497:PFDSM3638 RS00515
gene id: 186497:PFDSM3638_RS00515
uniprot id: A0A5C0XNL0
uniprot id: Q8U4H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

186497:PFDSM3638 RS00015
gene id: 186497:PFDSM3638_RS00015
uniprot id: A0A5C0XPM5
uniprot id: P81409
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

186497:PFDSM3638 RS10060
gene id: 186497:PFDSM3638_RS10060
uniprot id: A0A5C0XUM1
uniprot id: Q8TZK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit (PubMed:23222135). Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

186497:PFDSM3638 RS05055
gene id: 186497:PFDSM3638_RS05055
uniprot id: A0A5C0XS45
uniprot id: Q8U249
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

186497:PFDSM3638 RS05925
gene id: 186497:PFDSM3638_RS05925
uniprot id: A0A5C0XQ69
uniprot id: Q8U1M8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

186497:PFDSM3638 RS00375
gene id: 186497:PFDSM3638_RS00375
uniprot id: A0A5C0XMC7
uniprot id: Q8U4J5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

186497:PFDSM3638 RS09460
gene id: 186497:PFDSM3638_RS09460
uniprot id: A0A5C0XRS7
uniprot id: P61879
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Encapsulin nanocompartment
messages: Homotetramer.
messages: Possible cargo protein of a type 4B encapsulin nanocompartment (Probable). Active in the presence of NAD and NADP, prefers NADP (By similarity).

186497:PFDSM3638 RS05330
gene id: 186497:PFDSM3638_RS05330
uniprot id: A0A5C0XR26
uniprot id: P61883
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

186497:PFDSM3638 RS01535
gene id: 186497:PFDSM3638_RS01535
uniprot id: A0A5C0XQD1
uniprot id: Q8U3Y3
names: Similarity
messages: Belongs to the peptidase S9C family.

186497:PFDSM3638 RS04415
gene id: 186497:PFDSM3638_RS04415
uniprot id: A0A5C0XNZ6
uniprot id: Q8U2F9
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS01270
gene id: 186497:PFDSM3638_RS01270
uniprot id: A0A5C0XLW9
uniprot id: Q8U429
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

186497:PFDSM3638 RS06015
gene id: 186497:PFDSM3638_RS06015
uniprot id: Q8U1K9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the NADH-dependent reduction of rubredoxin (Rd), a small iron-containing redox protein (PubMed:10464233, PubMed:11398485, PubMed:15746356). Can also reduce other electron carriers, including 2,6-dichlorophenol indophenol, benzyl viologen and menadione, but rubredoxin is the most efficient electron acceptor (PubMed:10464233, PubMed:11398485, PubMed:15746356). Does not reduce ferredoxin (PubMed:10464233). Shows comparable activity with NADPH and NADH as electron donors, but NADPH is probably the preferred physiological electron donor (PubMed:10464233, PubMed:11398485). Is probably part of an oxygen detoxification system that protects P.furiosus during exposure to oxygen (PubMed:15746356).
messages: Cytoplasm
messages: Monomer.
messages: NROR, unlike the vast majority of enzymes from hyperthermophilic sources, shows considerable activity at low temperatures.

186497:PFDSM3638 RS08630
gene id: 186497:PFDSM3638_RS08630
uniprot id: A0A5C0XTW2
uniprot id: Q8U0A2
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS09835
gene id: 186497:PFDSM3638_RS09835
uniprot id: A0A5C0XRZ0
uniprot id: Q8TZP0
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

186497:PFDSM3638 RS05775
gene id: 186497:PFDSM3638_RS05775
uniprot id: A0A5C0XPA9
uniprot id: Q8U1Q7
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS05345
gene id: 186497:PFDSM3638_RS05345
uniprot id: A0A5C0XPW8
uniprot id: Q8U1Z4
names: Similarity
messages: Belongs to the ZPR1 family.

186497:PFDSM3638 RS02665
gene id: 186497:PFDSM3638_RS02665
uniprot id: A0A5C0XP98
uniprot id: Q8U3D5
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

186497:PFDSM3638 RS02400
gene id: 186497:PFDSM3638_RS02400
uniprot id: A0A5C0XQT3
uniprot id: Q8U3I5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

186497:PFDSM3638 RS08095
gene id: 186497:PFDSM3638_RS08095
uniprot id: A0A5C0XWQ2
uniprot id: Q8U0J0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

186497:PFDSM3638 RS07885
gene id: 186497:PFDSM3638_RS07885
uniprot id: A0A5C0XR29
uniprot id: Q8U0M8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS03195
gene id: 186497:PFDSM3638_RS03195
uniprot id: Q8U336
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: Both ssDNase and ssRNase are inhibited by EDTA.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity. Acts as a ssDNA and ssRNA nuclease, probably with both exo- and endonuclease activities. Activity is higher for DNA than RNA. Templates include 2',3'-cAMP and 2',3'-cGMP.
messages: Monomer.
messages: Proteins of this family have an N-terminal nuclease domain and a C-terminal helicase/ATPase domain. In some CRISPR/Cas systems the domains are swapped, in others they are encoded separately.
messages: ssDNase activity requires Mg(2+), ssRNase activity does not require cations.

186497:PFDSM3638 RS00980
gene id: 186497:PFDSM3638_RS00980
uniprot id: A0A5C0XM33
uniprot id: Q8U484
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS00345
gene id: 186497:PFDSM3638_RS00345
uniprot id: A0A5C0XLL9
uniprot id: Q8U4K2
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

186497:PFDSM3638 RS08340
gene id: 186497:PFDSM3638_RS08340
uniprot id: A0A5C0XPT9
uniprot id: Q8U0E7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS9 family.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS02285
gene id: 186497:PFDSM3638_RS02285
uniprot id: A0A5C0XND5
uniprot id: Q8U3K7
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

186497:PFDSM3638 RS09270
gene id: 186497:PFDSM3638_RS09270
uniprot id: Q8TZY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetate CoA ligase beta subunit family.
messages: Catalyzes the reversible formation of acetate and ATP from acetyl-CoA by using ADP and phosphate. Can use other substrates such as phenylacetyl-CoA, indoleacetyl-CoA and isobutyryl-CoA, but not succinyl-CoA. Seems to be involved primarily in the degradation of aryl-CoA esters to the corresponding acids. Participates in the conversion of acetyl-CoA to acetate and in the degradation of branched-chain amino acids via branched-chain-acyl-CoA esters.
messages: Heterotetramer of two alpha and two beta subunits.

186497:PFDSM3638 RS09940
gene id: 186497:PFDSM3638_RS09940
uniprot id: A0A5C0XR63
uniprot id: Q8TZM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

186497:PFDSM3638 RS06160
gene id: 186497:PFDSM3638_RS06160
uniprot id: A0A5C0XPG0
uniprot id: Q8U1H8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

186497:PFDSM3638 RS07395
gene id: 186497:PFDSM3638_RS07395
uniprot id: A0A5C0XS77
uniprot id: Q8U0W2
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS05020
gene id: 186497:PFDSM3638_RS05020
uniprot id: A0A5C0XQW1
uniprot id: Q8U257
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS04910
gene id: 186497:PFDSM3638_RS04910
uniprot id: A0A5C0XQT9
uniprot id: Q51798
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

186497:PFDSM3638 RS02670
gene id: 186497:PFDSM3638_RS02670
uniprot id: A0A5C0XRQ6
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

186497:PFDSM3638 RS05200
gene id: 186497:PFDSM3638_RS05200
uniprot id: A0A5C0XR23
uniprot id: Q8U220
names: Similarity
messages: Belongs to the CutA family.

186497:PFDSM3638 RS00970
gene id: 186497:PFDSM3638_RS00970
uniprot id: A0A5C0XN04
uniprot id: Q8U486
names: Similarity
messages: Belongs to the glutamate synthase family.

186497:PFDSM3638 RS01940
gene id: 186497:PFDSM3638_RS01940
uniprot id: A0A5C0XN37
uniprot id: Q8U3R3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: Binds crRNA.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), also called psiRNA (prokaryotic silencing) in this organism (Potential).
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: No in vitro nuclease activity has been observed against crRNA for this protein.

186497:PFDSM3638 RS05000
gene id: 186497:PFDSM3638_RS05000
uniprot id: A0A5C0XS33
uniprot id: Q8U261
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

186497:PFDSM3638 RS02375
gene id: 186497:PFDSM3638_RS02375
uniprot id: A0A5C0XN84
uniprot id: Q8U3J0
names: Similarity
messages: Belongs to the CinA family.

186497:PFDSM3638 RS08005
gene id: 186497:PFDSM3638_RS08005
uniprot id: A0A5C0XR35
uniprot id: Q8U0K8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

186497:PFDSM3638 RS09490
gene id: 186497:PFDSM3638_RS09490
uniprot id: A0A5C0XT55
uniprot id: Q8TH04
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

186497:PFDSM3638 RS09840
gene id: 186497:PFDSM3638_RS09840
uniprot id: A0A5C0XR46
uniprot id: Q8TZN9
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

186497:PFDSM3638 RS00170
gene id: 186497:PFDSM3638_RS00170
uniprot id: A0A5C0XPQ5
uniprot id: Q8U4N2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

186497:PFDSM3638 RS04620
gene id: 186497:PFDSM3638_RS04620
uniprot id: A0A5C0XRV9
uniprot id: Q8U2C1
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS01020
gene id: 186497:PFDSM3638_RS01020
uniprot id: A0A5C0XT67
uniprot id: Q8U477
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

186497:PFDSM3638 RS05690
gene id: 186497:PFDSM3638_RS05690
uniprot id: A0A5C0XNM0
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

186497:PFDSM3638 RS06780
gene id: 186497:PFDSM3638_RS06780
uniprot id: A0A5C0XW10
uniprot id: Q8U172
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

186497:PFDSM3638 RS00485
gene id: 186497:PFDSM3638_RS00485
uniprot id: A0A5C0XME6
uniprot id: Q8U4H6
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA (By similarity).
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

186497:PFDSM3638 RS05780
gene id: 186497:PFDSM3638_RS05780
uniprot id: A0A5C0XSI1
uniprot id: Q8U1Q6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

186497:PFDSM3638 RS04485
gene id: 186497:PFDSM3638_RS04485
uniprot id: Q8U2E5
names: Activity Regulation
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 [4Fe-4S] clusters.
messages: Cytoplasm
messages: Heterotetramer of alpha, beta, gamma and delta subunits. The nickel-containing alpha and delta subunits constitute the hydrogenase activity. The beta and gamma subunits (flavin-containing dimer) constitute the sulfur reductase activity.
messages: Part of a bifunctional enzyme complex that functions as an NADPH-dependent hydrogen-evolving hydrogenase with sulfur reducing activity. May play a role in hydrogen cycling during fermentative growth. Activity not exhibited with NAD. The beta and gamma subunits form the sulfur reducing component that catalyzes the cytoplasmic production of hydrogen sulfide in the presence of elemental sulfur. Not active in the presence of sodium sulfate, sodium sulfite, sodium thiosulfate or cysteine.
messages: Stimulated by rubredoxin at pH 7.6 but not ferredoxin.

186497:PFDSM3638 RS05520
gene id: 186497:PFDSM3638_RS05520
uniprot id: A0A5C0XSD1
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

186497:PFDSM3638 RS00475
gene id: 186497:PFDSM3638_RS00475
uniprot id: A0A5C0XSY9
uniprot id: Q9P9H1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL). Both participate in formation of the active center, but the ATP-binding site is exclusively located on the small subunit.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
messages: The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA (PubMed:11135672).

186497:PFDSM3638 RS05815
gene id: 186497:PFDSM3638_RS05815
uniprot id: A0A5C0XVJ2
uniprot id: Q8U1P9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

186497:PFDSM3638 RS04305
gene id: 186497:PFDSM3638_RS04305
uniprot id: A0A5C0XQI8
uniprot id: A6YQV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

186497:PFDSM3638 RS07895
gene id: 186497:PFDSM3638_RS07895
uniprot id: A0A5C0XQ82
uniprot id: Q8U0M7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

186497:PFDSM3638 RS08910
gene id: 186497:PFDSM3638_RS08910
uniprot id: A0A5C0XSY1
uniprot id: Q8U051
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

186497:PFDSM3638 RS07185
gene id: 186497:PFDSM3638_RS07185
uniprot id: A0A5C0XQN8
uniprot id: Q8U100
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS09525
gene id: 186497:PFDSM3638_RS09525
uniprot id: A0A5C0XSA9
uniprot id: Q8TZU6
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS00260
gene id: 186497:PFDSM3638_RS00260
uniprot id: A0A5C0XMB1
uniprot id: Q8U4L3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

186497:PFDSM3638 RS08700
gene id: 186497:PFDSM3638_RS08700
uniprot id: A0A5C0XSU0
uniprot id: Q8U088
names: Similarity
messages: Belongs to the TrpC family.

186497:PFDSM3638 RS06660
gene id: 186497:PFDSM3638_RS06660
uniprot id: E7FHF8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 nickel ion per subunit.
messages: Binds 2 [4Fe-4S] clusters.
messages: Cytoplasm
messages: Dimer of heterotetramer of alpha, beta, gamma and delta subunits. The nickel-containing alpha and delta subunits constitute the hydrogenase activity. The beta and gamma subunits (flavin-containing dimer) constitute the sulfur reductase activity.
messages: Part of a bifunctional enzyme complex that functions as a hydrogen-evolving hydrogenase with sulfur-reducing activity. May play a role in hydrogen cycling during fermentative growth. Activity exhibited with NAD in addition to NADPH. The alpha and delta subunits form the hydrogenase component that catalyzes the reduction of protons to evolve hydrogen.

186497:PFDSM3638 RS00885
gene id: 186497:PFDSM3638_RS00885
uniprot id: A0A5C0XQ27
uniprot id: P58888
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

186497:PFDSM3638 RS06655
gene id: 186497:PFDSM3638_RS06655
uniprot id: A0A5C0XP08
uniprot id: E7FHW8
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cytoplasm
messages: Dimer of heterotetramer of alpha, beta, gamma and delta subunits. The nickel-containing alpha and delta subunits constitute the hydrogenase activity. The beta and gamma subunits (flavin-containing dimer) constitute the sulfur reductase activity.
messages: Part of a bifunctional enzyme complex that functions as a hydrogen-evolving hydrogenase with sulfur-reducing activity. May play a role in hydrogen cycling during fermentative growth. Activity exhibited with NAD in addition to NADPH. The beta and gamma subunits form the sulfur-reducing component that catalyzes the cytoplasmic production of hydrogen sulfide in the presence of elemental sulfur.

186497:PFDSM3638 RS02205
gene id: 186497:PFDSM3638_RS02205
uniprot id: A0A5C0XMT2
uniprot id: E7FI31
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS09655
gene id: 186497:PFDSM3638_RS09655
uniprot id: A0A5C0XRK6
uniprot id: Q8TZS2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

186497:PFDSM3638 RS07625
gene id: 186497:PFDSM3638_RS07625
uniprot id: A0A5C0XRF0
uniprot id: Q8U0S5
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS05510
gene id: 186497:PFDSM3638_RS05510
uniprot id: A0A5C0XPV5
uniprot id: P46214
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

186497:PFDSM3638 RS03090
gene id: 186497:PFDSM3638_RS03090
uniprot id: A0A5C0XU91
uniprot id: Q8U357
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

186497:PFDSM3638 RS04100
gene id: 186497:PFDSM3638_RS04100
uniprot id: A0A5C0XP86
uniprot id: Q8U2L5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL14 family.
messages: May be present in 2 copies per 70S ribosome (PubMed:23222135). Part of the 50S ribosomal subunit, where it binds 23S rRNA at its canonical site near helices 25 and 41, as well as a possible second 50S binding site near helix 58.

186497:PFDSM3638 RS08945
gene id: 186497:PFDSM3638_RS08945
uniprot id: A0A5C0XS02
uniprot id: Q8U044
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

186497:PFDSM3638 RS01325
gene id: 186497:PFDSM3638_RS01325
uniprot id: A0A5C0XNI2
uniprot id: Q8U419
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS08980
gene id: 186497:PFDSM3638_RS08980
uniprot id: A0A5C0XRJ2
uniprot id: Q8U037
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

186497:PFDSM3638 RS06550
gene id: 186497:PFDSM3638_RS06550
uniprot id: Q8U1B3
names: Function
names: Similarity
messages: Belongs to the UPF0165 family.
messages: Possibly the antitoxin component of a type II toxin-antitoxin (TA) system.

186497:PFDSM3638 RS07425
gene id: 186497:PFDSM3638_RS07425
uniprot id: A0A5C0XTC3
uniprot id: Q8U0V6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL40 family.
messages: Part of the 50S ribosomal subunit.

186497:PFDSM3638 RS07870
gene id: 186497:PFDSM3638_RS07870
uniprot id: A0A5C0XSF4
uniprot id: Q8U0N1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

186497:PFDSM3638 RS01680
gene id: 186497:PFDSM3638_RS01680
uniprot id: A0A5C0XTI7
uniprot id: P50251
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

186497:PFDSM3638 RS06905
gene id: 186497:PFDSM3638_RS06905
uniprot id: A0A5C0XW32
uniprot id: P61885
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS03735
gene id: 186497:PFDSM3638_RS03735
uniprot id: A0A5C0XRE7
uniprot id: Q8U2T4
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS03730
gene id: 186497:PFDSM3638_RS03730
uniprot id: A0A5C0XNH9
uniprot id: Q8U2T5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

186497:PFDSM3638 RS00960
gene id: 186497:PFDSM3638_RS00960
uniprot id: A0A5C0XMN5
uniprot id: Q53554
names: Similarity
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Homodimer.

186497:PFDSM3638 RS01865
gene id: 186497:PFDSM3638_RS01865
uniprot id: A0A5C0XNW6
uniprot id: Q8U3U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

186497:PFDSM3638 RS05625
gene id: 186497:PFDSM3638_RS05625
uniprot id: A0A5C0XP85
uniprot id: Q8U1T7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

186497:PFDSM3638 RS10405
gene id: 186497:PFDSM3638_RS10405
uniprot id: A0A5C0XS85
uniprot id: Q8TZD7
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.
messages: Possibly the antitoxin component of a type II toxin-antitoxin (TA) system.

186497:PFDSM3638 RS07730
gene id: 186497:PFDSM3638_RS07730
uniprot id: A0A5C0XQ58
uniprot id: Q8U0Q6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

186497:PFDSM3638 RS04720
gene id: 186497:PFDSM3638_RS04720
uniprot id: A0A5C0XPH5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS06640
gene id: 186497:PFDSM3638_RS06640
uniprot id: Q8U195
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: A bifunctional enzyme that catalyzes the reduction of elemental sulfur or polysulfide to hydrogen sulfide with NADPH as electron donor. Also functions as a reduced ferredoxin:NADP oxidoreductase with a very high affinity for reduced ferredoxin. Exhibits a broad specificity for various physiological and non-physiological substrates with varied reduction potentials such as methyl viologen, benzyl viologen, FAD, FMN, methylene blue, 2,6-dichlorophenolindophenol (DCIP), cytochrome C and ferricyanide with highest preference for benzyl viologen. Does not reduce fumarate, succinate, nitrate, nitrite, sulfate, sulfite or protons. Does not possess any hydrogenase activity or NADPH-dependent glutamate synthase activity.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cytoplasm
messages: Heterodimer of alpha and beta subunits.

186497:PFDSM3638 RS10050
gene id: 186497:PFDSM3638_RS10050
uniprot id: A0A5C0XS28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

186497:PFDSM3638 RS08105
gene id: 186497:PFDSM3638_RS08105
uniprot id: A0A5C0XR55
uniprot id: Q8U0I8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS04890
gene id: 186497:PFDSM3638_RS04890
uniprot id: Q51802
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

186497:PFDSM3638 RS05630
gene id: 186497:PFDSM3638_RS05630
uniprot id: A0A5C0XSF1
uniprot id: Q8U1T6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

186497:PFDSM3638 RS04495
gene id: 186497:PFDSM3638_RS04495
uniprot id: E7FHU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 nickel ion per tetramer.
messages: Binds 2 [4Fe-4S] clusters.
messages: Cytoplasm
messages: Heterotetramer of alpha, beta, gamma and delta subunits. The nickel-containing alpha and delta subunits constitute the hydrogenase activity. The beta and gamma subunits (flavin-containing dimer) constitute the sulfur reductase activity.
messages: Part of a bifunctional enzyme complex that functions as an NADPH-dependent hydrogen-evolving hydrogenase with sulfur reducing activity. May play a role in hydrogen cycling during fermentative growth. Activity not exhibited with NAD. The alpha and delta subunits form the hydrogenase component that catalyzes the reduction of protons to evolve hydrogen.

186497:PFDSM3638 RS09530
gene id: 186497:PFDSM3638_RS09530
uniprot id: Q8TZU5
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS05275
gene id: 186497:PFDSM3638_RS05275
uniprot id: A0A5C0XNZ0
uniprot id: Q8TH08
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

186497:PFDSM3638 RS01120
gene id: 186497:PFDSM3638_RS01120
uniprot id: A0A5C0XMC6
uniprot id: Q8U459
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

186497:PFDSM3638 RS07575
gene id: 186497:PFDSM3638_RS07575
uniprot id: A0A5C0XPG1
uniprot id: Q8U0T4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

186497:PFDSM3638 RS07020
gene id: 186497:PFDSM3638_RS07020
uniprot id: A0A5C0XTR1
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

186497:PFDSM3638 RS06960
gene id: 186497:PFDSM3638_RS06960
uniprot id: A0A5C0XQK0
uniprot id: Q8U144
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

186497:PFDSM3638 RS09200
gene id: 186497:PFDSM3638_RS09200
uniprot id: A0A5C0XS49
uniprot id: Q8U000
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit (PubMed:23222135). Contacts protein L29.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

186497:PFDSM3638 RS01045
gene id: 186497:PFDSM3638_RS01045
uniprot id: A0A5C0XQ52
names: Similarity
messages: Belongs to the HPS/KGPDC family. HPS subfamily.
messages: Belongs to the SIS family. PHI subfamily.

186497:PFDSM3638 RS06900
gene id: 186497:PFDSM3638_RS06900
uniprot id: A0A5C0XQJ0
uniprot id: Q8U152
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

186497:PFDSM3638 RS00020
gene id: 186497:PFDSM3638_RS00020
uniprot id: P81414
names: Similarity
messages: Belongs to the UPF0173 family.

186497:PFDSM3638 RS00820
gene id: 186497:PFDSM3638_RS00820
uniprot id: A0A5C0XMK0
uniprot id: Q8U4B3
names: Function
messages: Part of a potassium transport system.

186497:PFDSM3638 RS00560
gene id: 186497:PFDSM3638_RS00560
uniprot id: A0A5C0XM55
uniprot id: Q8U4G1
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: At temperatures higher than 95 degrees Celsius or by oxidative shock.
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Homodimer.
messages: Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high-temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to various amine acceptors such as agmatine, cadaverine (1,5-diaminopentane), putrescine (1,4-diaminobutane) and 1,3-diaminopropane. The biosynthesis of norspermine and thermospermine from sym-norspermidine and spermidine has been also observed, but with a very low activity. The reaction involves a nucleophilic attack on the C-3 methylene of the propylamine moiety adjacent to the positively charged sulfur of decarboxy-AdoMet.

186497:PFDSM3638 RS07800
gene id: 186497:PFDSM3638_RS07800
uniprot id: Q8U0P3
names: Activity Regulation
names: Function
names: Subunit
messages: DNA-binding protein involved in the repression of transcription of a large number of genes, thereby arresting growth, in response to environmental changes.
messages: Homodimer. Binds DNA as a dimer and an octamer.
messages: In the famine mode, FL11 forms dimers and acts as a repressor, leading to growth arrest. In the feast mode, in the presence of high concentrations of lysine or arginine, four dimers assemble into an octamer and cover the fl11 and lysine biosynthesis promoters. This leads to the inhibition of fl11 expression and lysine biosynthesis, decrease of the FL11 concentration in the cell, derepression of the target genes and activation of the metabolism.

186497:PFDSM3638 RS07680
gene id: 186497:PFDSM3638_RS07680
uniprot id: A0A5C0XTF7
uniprot id: Q8U0R5
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS01745
gene id: 186497:PFDSM3638_RS01745
uniprot id: A0A5C0XNB7
uniprot id: Q8U3S2
names: Similarity
messages: Belongs to the UPF0440 family.

186497:PFDSM3638 RS03245
gene id: 186497:PFDSM3638_RS03245
uniprot id: A0A5C0XUC1
uniprot id: Q8U326
names: Similarity
messages: Belongs to the GbsR family.

186497:PFDSM3638 RS07005
gene id: 186497:PFDSM3638_RS07005
uniprot id: A0A5C0XS56
uniprot id: Q8U135
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

186497:PFDSM3638 RS05560
gene id: 186497:PFDSM3638_RS05560
uniprot id: A0A5C0XQ07
uniprot id: Q8U1U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

186497:PFDSM3638 RS01890
gene id: 186497:PFDSM3638_RS01890
uniprot id: A0A5C0XTM4
uniprot id: Q8U3V0
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.
messages: Toxic component of a type II toxin-antitoxin (TA) system. An RNase.

186497:PFDSM3638 RS09420
gene id: 186497:PFDSM3638_RS09420
uniprot id: A0A5C0XUA6
uniprot id: Q8TZW1
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

186497:PFDSM3638 RS10270
gene id: 186497:PFDSM3638_RS10270
uniprot id: A0A5C0XSN9
uniprot id: Q8TZG0
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

186497:PFDSM3638 RS00740
gene id: 186497:PFDSM3638_RS00740
uniprot id: A0A5C0XM74
uniprot id: Q8U4C9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

186497:PFDSM3638 RS02610
gene id: 186497:PFDSM3638_RS02610
uniprot id: A0A5C0XQW8
uniprot id: Q8U3E6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

186497:PFDSM3638 RS02280
gene id: 186497:PFDSM3638_RS02280
uniprot id: A0A5C0XNJ7
uniprot id: Q8U3K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

186497:PFDSM3638 RS09980
gene id: 186497:PFDSM3638_RS09980
uniprot id: A0A5C0XS29
uniprot id: Q8TZL4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

186497:PFDSM3638 RS05975
gene id: 186497:PFDSM3638_RS05975
uniprot id: A0A5C0XQ77
names: Similarity
messages: Belongs to the pyruvate kinase family.

186497:PFDSM3638 RS00220
gene id: 186497:PFDSM3638_RS00220
uniprot id: A0A5C0XPR5
uniprot id: Q8U4M2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA. These sRNP particles form homodimers, giving rise to an asymmetric holoenzyme.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

186497:PFDSM3638 RS02080
gene id: 186497:PFDSM3638_RS02080
uniprot id: A0A5C0XSD5
names: Similarity
messages: Belongs to the GARS family.

186497:PFDSM3638 RS01840
gene id: 186497:PFDSM3638_RS01840
uniprot id: A0A5C0XTL3
uniprot id: Q8U3U1
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

186497:PFDSM3638 RS03840
gene id: 186497:PFDSM3638_RS03840
uniprot id: A0A5C0XUL2
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

186497:PFDSM3638 RS07450
gene id: 186497:PFDSM3638_RS07450
uniprot id: A0A5C0XQU4
names: Similarity
messages: Belongs to the AOR/FOR family.

186497:PFDSM3638 RS07830
gene id: 186497:PFDSM3638_RS07830
uniprot id: A0A5C0XWJ6
uniprot id: Q8U0N9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

186497:PFDSM3638 RS10335
gene id: 186497:PFDSM3638_RS10335
uniprot id: Q8TZE8
names: Biotechnology
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Absence of glutaminase activity, higher stability, and mesoactivity makes P.furiosus L-asparaginase and its mutants promising candidates for clinical as well as industrial usage.
messages: Belongs to the asparaginase 1 family.
messages: Catalyzes the hydrolysis of L-asparagine into L-aspartate and ammonia. Displays no glutaminase activity, a highly desirable therapeutic property.
messages: Consists of distinct N- and C-terminal domains (NPfA and CPfA, respectively), connected by a linker. NPfA acts as specific internal chaperone by mediating folding of its own C-domain (CPfA), but also functions as a non-specific molecular chaperone by preventing aggregation of unrelated proteins (PubMed:23551356, PubMed:25862541). The linker is dispensable since domains of this enzyme can assemble without the linker into a conjoined tetrameric form that exhibits higher activity than the parent enzyme, while each domain is inactive independently. The structural integrity of the conjoined enzyme is maintained through domain-domain interactions rather than the covalent linker (PubMed:25478837).
messages: Homodimer.
messages: Microbial L-asparaginase is considered as an important biopharmaceutical drug enzyme in the treatment of childhood acute lymphoblastic leukemia (ALL). It functions by reducing the availability of circulatory L-asparagine to tumor cells. The principle behind the cytotoxic effect of L-asparaginase stems from the fact that the leukemic lymphoblastic tumor cells and other blood tumor cells are auxotrophs towards the L-asparagine and exhibit low L-asparagine synthetase (ASNS) activity for de novo synthesis of L-asparagine. Therefore, these tumor cells are required for exogenous supply of L-asparagine for proliferation and survival. L-Asparaginase has also been used for making a diagnostic biosensor as the amount of ammonia produced by the action of the enzyme directly correlates to the level of L-asparagine in a patient's blood (Probable). P.furiosus L-asparaginase and its mutants show significant killing of cultured human leukemic cell lines HL60, MCF7, and K562 (PubMed:22166247).

186497:PFDSM3638 RS07780
gene id: 186497:PFDSM3638_RS07780
uniprot id: A0A5C0XQZ5
uniprot id: Q8U0P6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

186497:PFDSM3638 RS05360
gene id: 186497:PFDSM3638_RS05360
uniprot id: A0A5C0XSA2
uniprot id: Q8U1Z1
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

186497:PFDSM3638 RS10425
gene id: 186497:PFDSM3638_RS10425
uniprot id: A0A5C0XS90
uniprot id: Q8TZD4
names: Subcellular Location Annotation
messages: Membrane

186497:PFDSM3638 RS00335
gene id: 186497:PFDSM3638_RS00335
uniprot id: A0A5C0XSB1
uniprot id: Q8U4K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (WtpC), two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).

186497:PFDSM3638 RS08965
gene id: 186497:PFDSM3638_RS08965
uniprot id: A0A5C0XRI9
uniprot id: Q8U040
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

186497:PFDSM3638 RS00495
gene id: 186497:PFDSM3638_RS00495
uniprot id: A0A5C0XPV7
uniprot id: Q8U4H4
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

186497:PFDSM3638 RS01775
gene id: 186497:PFDSM3638_RS01775
uniprot id: A0A5C0XMM9
uniprot id: Q8U3S8
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

186497:PFDSM3638 RS09015
gene id: 186497:PFDSM3638_RS09015
uniprot id: E7FHP1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity is dependent on magnesium.
messages: Belongs to the acetate CoA ligase beta subunit family.
messages: Catalyzes the reversible formation of acetate and ATP from acetyl-CoA by using ADP and phosphate. Can use other substrates such as isobutyryl-CoA, propionyl-CoA and butyryl-CoA, but not indoleacetyl-CoA, phenylacetyl-CoA or succinyl-CoA. Seems to be involved primarily in the conversion of acetyl-CoA to acetate. Participates in the degradation of branched-chain amino acids via branched-chain-acyl-CoA esters.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta subunits.

186497:PFDSM3638 RS01645
gene id: 186497:PFDSM3638_RS01645
uniprot id: A0A5C0XMC9
uniprot id: Q8U3W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

186497:PFDSM3638 RS06350
gene id: 186497:PFDSM3638_RS06350
uniprot id: A0A5C0XQE1
uniprot id: Q8TH63
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.