185431:Tb09.211.1370
gene id: 185431:Tb09.211.1370
uniprot id: Q38E18
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

185431:Tb927.3.3840
gene id: 185431:Tb927.3.3840
uniprot id: Q57WC0
names: Similarity
messages: Belongs to the CWC16 family.

185431:Tb10.70.5340
gene id: 185431:Tb10.70.5340
uniprot id: Q38C05
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.6.1260
gene id: 185431:Tb927.6.1260
uniprot id: Q585C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

185431:Tb927.8.4090
gene id: 185431:Tb927.8.4090
uniprot id: Q581C9
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

185431:Tb10.61.1310
gene id: 185431:Tb10.61.1310
uniprot id: Q387Z1
names: Similarity
messages: Belongs to the CCDC53 family.

185431:Tb927.4.1720
gene id: 185431:Tb927.4.1720
uniprot id: Q581Q9
names: Subcellular Location Annotation
messages: cilium axoneme

185431:Tb927.7.3250
gene id: 185431:Tb927.7.3250
uniprot id: Q57YD5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

185431:Tb10.26.0590
gene id: 185431:Tb10.26.0590
uniprot id: Q389K4
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

185431:Tb10.26.0320
gene id: 185431:Tb10.26.0320
uniprot id: Q389I2
names: Similarity
messages: Belongs to the NAPRTase family.

185431:Tb927.6.2740
gene id: 185431:Tb927.6.2740
uniprot id: D6XI07
names: Similarity
messages: Belongs to the pyridoxine kinase family.

185431:Tb927.6.500
gene id: 185431:Tb927.6.500
uniprot id: Q581F5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.7.5360
gene id: 185431:Tb927.7.5360
uniprot id: Q57ZF3
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.7.1800
gene id: 185431:Tb927.7.1800
uniprot id: Q57V30
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.4.1690
gene id: 185431:Tb927.4.1690
uniprot id: Q581R2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

185431:Tb09.244.2725
gene id: 185431:Tb09.244.2725
uniprot id: Q38CY6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

185431:Tb10.61.2700
gene id: 185431:Tb10.61.2700
uniprot id: Q388I9
names: Subcellular Location Annotation
messages: Cytoplasm

185431:Tb09.160.2970
gene id: 185431:Tb09.160.2970
uniprot id: P86927
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA ligase 2 family.
messages: Component of the RNA editing complex (editosome), a 1600 kDa complex composed of at least 20 proteins (By similarity). Interacts with terminal uridylyltransferase MEAT1 (By similarity).
messages: Essential for RNA editing. RNA editing in kinetoplastid mitochondria inserts and deletes uridylates at multiple sites in pre-mRNAs as directed by guide RNAs.
messages: Mitochondrion

185431:Tb927.5.1450
gene id: 185431:Tb927.5.1450
uniprot id: Q57VB8
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.7.7470
gene id: 185431:Tb927.7.7470
uniprot id: Q57TY4
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.8.1650
gene id: 185431:Tb927.8.1650
uniprot id: Q580F8
names: Subcellular Location Annotation
messages: Membrane

185431:Tb09.160.2380
gene id: 185431:Tb09.160.2380
uniprot id: Q38FF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

185431:Tb927.3.2610
gene id: 185431:Tb927.3.2610
uniprot id: Q582X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
messages: Membrane

185431:Tb927.5.4440
gene id: 185431:Tb927.5.4440
uniprot id: Q57Z05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

185431:Tb927.8.3370
gene id: 185431:Tb927.8.3370
uniprot id: Q57YX6
names: Similarity
messages: Belongs to the MOG1 family.

185431:Tb10.61.0850
gene id: 185431:Tb10.61.0850
uniprot id: Q387W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

185431:Tb927.8.3560
gene id: 185431:Tb927.8.3560
uniprot id: Q580X6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability. Involved in processing of minicircle Okazaki fragments.
messages: Mitochondrion
messages: Monomer.

185431:Tb927.8.4810
gene id: 185431:Tb927.8.4810
uniprot id: Q57UX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

185431:TB927.1.3050
gene id: 185431:TB927.1.3050
uniprot id: Q4GYR8
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb927.3.4750
gene id: 185431:Tb927.3.4750
uniprot id: Q582Q6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

185431:Tb10.70.2610
gene id: 185431:Tb10.70.2610
uniprot id: Q38BE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.

185431:Tb10.6k15.2060
gene id: 185431:Tb10.6k15.2060
uniprot id: Q38AC2
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

185431:Tb927.3.1220
gene id: 185431:Tb927.3.1220
uniprot id: D6XD30
uniprot id: Q57XV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
messages: Forms a heterodimer with a member of the SLX4 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

185431:Tb10.61.1190
gene id: 185431:Tb10.61.1190
uniprot id: Q387Y2
names: Similarity
messages: Belongs to the TBCC family.

185431:TB927.1.1630
gene id: 185431:TB927.1.1630
uniprot id: Q4GZ56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

185431:Tb927.5.1610
gene id: 185431:Tb927.5.1610
uniprot id: Q585J5
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

185431:Tb09.211.0865
gene id: 185431:Tb09.211.0865
uniprot id: Q386L1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

185431:Tb927.6.3050
gene id: 185431:Tb927.6.3050
uniprot id: Q583M9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

185431:Tb927.8.1240
gene id: 185431:Tb927.8.1240
uniprot id: Q57VN1
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

185431:Tb10.70.7240
gene id: 185431:Tb10.70.7240
uniprot id: Q38CE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of genome stability.
messages: Monomer.
messages: Nucleus

185431:Tb10.406.0410
gene id: 185431:Tb10.406.0410
uniprot id: Q389T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb09.211.1210
gene id: 185431:Tb09.211.1210
uniprot id: Q38E34
names: Similarity
messages: Belongs to the RecA family. DMC1 subfamily.

185431:Tb927.2.2970
gene id: 185431:Tb927.2.2970
uniprot id: Q587G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

185431:Tb10.70.2980
gene id: 185431:Tb10.70.2980
uniprot id: Q38BH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

185431:Tb09.211.0180
gene id: 185431:Tb09.211.0180
uniprot id: Q38EE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pescadillo family.
messages: Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
messages: nucleolus
messages: nucleoplasm

185431:Tb927.7.2530
gene id: 185431:Tb927.7.2530
uniprot id: Q57XM1
names: Similarity
messages: Belongs to the acetyltransferase family. GNAT subfamily.

185431:Tb927.7.5140
gene id: 185431:Tb927.7.5140
uniprot id: Q57ZH5
names: Similarity
messages: Belongs to the BIVM family.

185431:Tb927.4.1500
gene id: 185431:Tb927.4.1500
uniprot id: Q581T1
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase that unwinds RNA in a 3' to 5' direction and that plays an important role in mitochondrial mRNA editing, a process involving the addition and deletion of uridine (U) nucleotides in the pre-mRNA (PubMed:19850921, PubMed:26769962, PubMed:31034523). As part of the RET2-containing gRNA-binding (RET2-GRBC) complex, acts as a scaffold for the assembly of mRNA-gRNA hybrids and the recruitment of the RNA editing core (RECC) complex (PubMed:25928631, PubMed:26769962). Regulates several steps of mRNA editing by the MRBC3010/GRBC6 containing gRNA-binding (MRBC3010-GRBC) complex including loading of unedited mRNA, editing in the first sequence block and subsequent editing progression across multiple sequence blocks (PubMed:25928631). Also, regulates the RNA substrate content of the MRBC3010-GRBC complex as well as the association of this complex with mitoribosomes (PubMed:25928631).
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Component of the REH2-associated complex (REH2C) composed of helicase REH2, associated factors H2F1 and H2F2, and mRNAs at various editing stages; the formation of the complex is RNA-independent (PubMed:26769962, PubMed:31034523). Within the complex, interacts with H2F1; the interaction is direct (PubMed:26769962, PubMed:31034523). Interacts transiently, in a RNA-dependent manner, with various editing complexes including the RNA editing core (RECC) complex, the gRNA-binding (GRBC) complex (also known as the MRB1 complex) and the RNA editing mediator (REMC) complex (PubMed:19850921, PubMed:25928631, PubMed:26769962, PubMed:31034523). Interacts with GAP1/GRBC2 via RNA forming a variant of the GRBC complex known as REH2-GRBC complex (PubMed:19850921, PubMed:25928631, PubMed:26769962, PubMed:31034523). Interacts with mitochondrial ribosomes (PubMed:19850921).
messages: Expressed at the procyclic stage (at protein level).
messages: Mitochondrion
messages: RNAi-mediated knockdown at the procyclic stage causes a loss of RNA unwinding activity (PubMed:26769962). Reduces association of H2F1 and abolishes H2F2 association with components of various editing complexes (PubMed:26769962). RNAi-mediated knockdown at the procyclic stage inhibits editing at early 3' sites on pre-mRNA substrates without affecting the interactions between MRB3010/GRBC6, GAP1/GRBC2, RGG2, REL1 and gRNA (PubMed:25928631). Decreases the ratio of unedited mRNA substrates in the MRB3010/GRBC6-MRB complex and the association of never-edited mRNA and 9SrRNA with the MRB3010-MRB complex (PubMed:25928631). Also, causes a decrease in the steady-state levels of guide RNA (gRNA) (PubMed:19850921).
messages: The DRBM domain is required for binding to guide RNAs (gRNA) and mRNAs which facilitates the association with the GRBC complex.

185431:Tb927.6.1390
gene id: 185431:Tb927.6.1390
uniprot id: Q585A8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.7.6350
gene id: 185431:Tb927.7.6350
uniprot id: Q582M4
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

185431:Tb10.70.7270
gene id: 185431:Tb10.70.7270
uniprot id: Q38CF2
names: Similarity
messages: Belongs to the thymidine kinase family.

185431:Tb927.7.3360
gene id: 185431:Tb927.7.3360
uniprot id: Q57WF1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

185431:Tb927.7.4830
gene id: 185431:Tb927.7.4830
uniprot id: Q57X99
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.8.7840
gene id: 185431:Tb927.8.7840
uniprot id: Q57U59
names: Similarity
messages: Belongs to the dynein heavy chain family.

185431:Tb927.3.2230
gene id: 185431:Tb927.3.2230
uniprot id: Q582T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

185431:Tb927.8.3690
gene id: 185431:Tb927.8.3690
uniprot id: Q580Y9
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

185431:Tb927.6.3210
gene id: 185431:Tb927.6.3210
uniprot id: Q584W4
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb09.211.0700
gene id: 185431:Tb09.211.0700
uniprot id: Q38E87
names: Subunit
messages: Homooctamer. Dimer of tetramers.

185431:Tb927.6.1280
gene id: 185431:Tb927.6.1280
uniprot id: Q585B9
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

185431:Tb927.7.3780
gene id: 185431:Tb927.7.3780
uniprot id: Q57WJ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

185431:Tb927.2.4980
gene id: 185431:Tb927.2.4980
uniprot id: Q586T6
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

185431:Tb927.3.4540
gene id: 185431:Tb927.3.4540
uniprot id: Q580I8
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb927.8.5440
gene id: 185431:Tb927.8.5440
uniprot id: Q57UL6
names: Function
names: Similarity
messages: Belongs to the calflagin family.
messages: May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form.

185431:Tb09.160.0630
gene id: 185431:Tb09.160.0630
uniprot id: Q38FX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM10 family.
messages: Nucleus

185431:Tb10.70.5670
gene id: 185431:Tb10.70.5670
uniprot id: P86934
uniprot id: P86939
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Phosphatidylethanolamine (PE) is a direct precursor of the ethanolamine-phosphoglycerol (EPG) moiety.
messages: The Kennedy pathway is the major route for phosphatidylethanolamine (PE) synthesis, as shown by reduced levels after using RNAi against the first two enzymes of the Kennedy pathway.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

185431:Tb09.211.0110
gene id: 185431:Tb09.211.0110
uniprot id: Q38EC5
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

185431:Tb927.2.6280
gene id: 185431:Tb927.2.6280
uniprot id: Q586M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

185431:Tb927.7.4390
gene id: 185431:Tb927.7.4390
uniprot id: Q57X55
names: Similarity
messages: Belongs to the threonine synthase family.

185431:Tb10.389.0300
gene id: 185431:Tb10.389.0300
uniprot id: Q388T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

185431:Tb09.211.1250
gene id: 185431:Tb09.211.1250
uniprot id: Q38E30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.

185431:Tb10.61.2070
gene id: 185431:Tb10.61.2070
uniprot id: Q388D3
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

185431:Tb09.160.4570
gene id: 185431:Tb09.160.4570
uniprot id: Q38EV1
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

185431:Tb927.4.2480
gene id: 185431:Tb927.4.2480
uniprot id: Q584D9
names: Similarity
messages: Belongs to the type-1 OGG1 family.

185431:Tb10.6k15.0550
gene id: 185431:Tb10.6k15.0550
uniprot id: Q38A00
names: Cofactor
names: Similarity
messages: Belongs to the alternative oxidase family.
messages: Binds 2 iron ions per subunit.

185431:Tb10.100.0090
gene id: 185431:Tb10.100.0090
uniprot id: Q38CL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Vacuole membrane

185431:Tb10.70.4940
gene id: 185431:Tb10.70.4940
uniprot id: Q38BX3
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

185431:Tb927.3.4340
gene id: 185431:Tb927.3.4340
uniprot id: Q580K8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.

185431:Tb09.211.0350
gene id: 185431:Tb09.211.0350
uniprot id: Q38EC4
names: Similarity
messages: Belongs to the adenylate kinase family.

185431:Tb927.6.4220
gene id: 185431:Tb927.6.4220
uniprot id: Q586Y9
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb09.160.4600
gene id: 185431:Tb09.160.4600
uniprot id: Q38EU8
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.3.2340
gene id: 185431:Tb927.3.2340
uniprot id: Q582U7
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.

185431:Tb927.6.1080
gene id: 185431:Tb927.6.1080
uniprot id: Q585D9
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

185431:Tb927.3.1920
gene id: 185431:Tb927.3.1920
uniprot id: Q57ZB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Cytoplasm
messages: Nucleus

185431:Tb10.70.0465
gene id: 185431:Tb10.70.0465
uniprot id: Q38AW9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

185431:Tb09.244.2310
gene id: 185431:Tb09.244.2310
uniprot id: Q38CU3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.6k15.2890
gene id: 185431:Tb10.6k15.2890
uniprot id: Q38AJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

185431:Tb10.61.3180
gene id: 185431:Tb10.61.3180
uniprot id: Q388M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Membrane

185431:Tb927.3.4470
gene id: 185431:Tb927.3.4470
uniprot id: Q580J5
names: Subcellular Location Annotation
messages: Cytoplasm

185431:Tb927.4.2520
gene id: 185431:Tb927.4.2520
uniprot id: Q584D5
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-57 and Arg-60) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

185431:Tb927.4.4540
gene id: 185431:Tb927.4.4540
uniprot id: Q583D9
names: Subcellular Location Annotation
messages: Nucleus

185431:Tb09.211.1380
gene id: 185431:Tb09.211.1380
uniprot id: Q38E17
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

185431:Tb10.61.0330
gene id: 185431:Tb10.61.0330
uniprot id: Q387R9
names: Similarity
messages: Belongs to the TBP family.

185431:Tb927.4.5700
gene id: 185431:Tb927.4.5700
uniprot id: Q580N8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.8.7860
gene id: 185431:Tb927.8.7860
uniprot id: Q57U57
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.7.5950
gene id: 185431:Tb927.7.5950
uniprot id: Q57VL6
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.70.6470
gene id: 185431:Tb10.70.6470
uniprot id: Q38C91
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

185431:Tb10.70.3680
gene id: 185431:Tb10.70.3680
uniprot id: Q38BN0
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb09.211.2410
gene id: 185431:Tb09.211.2410
uniprot id: Q38DR5
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.4.3870
gene id: 185431:Tb927.4.3870
uniprot id: Q583I1
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.6.1400
gene id: 185431:Tb927.6.1400
uniprot id: Q585A7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

185431:Tb927.3.2240
gene id: 185431:Tb927.3.2240
uniprot id: Q582T7
names: Similarity
messages: Belongs to the BROX family.

185431:Tb09.211.3330
gene id: 185431:Tb09.211.3330
uniprot id: Q38DH3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

185431:Tb927.2.1680
gene id: 185431:Tb927.2.1680
uniprot id: Q585R9
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

185431:Tb927.3.2540
gene id: 185431:Tb927.3.2540
uniprot id: Q582W6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.61.0110
gene id: 185431:Tb10.61.0110
uniprot id: Q387Q0
names: Similarity
messages: Belongs to the AAA ATPase family.

185431:Tb10.70.5480
gene id: 185431:Tb10.70.5480
uniprot id: Q38C19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

185431:Tb927.8.8030
gene id: 185431:Tb927.8.8030
uniprot id: Q57U42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

185431:Tb927.7.3940
gene id: 185431:Tb927.7.3940
uniprot id: Q57UM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Membrane
messages: Monomer.

185431:Tb927.4.930
gene id: 185431:Tb927.4.930
uniprot id: Q580C1
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

185431:Tb927.3.5660
gene id: 185431:Tb927.3.5660
uniprot id: Q57VH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb10.389.0470
gene id: 185431:Tb10.389.0470
uniprot id: Q388U3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb927.3.780
gene id: 185431:Tb927.3.780
uniprot id: D6XCY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus

185431:TB927.1.1140
gene id: 185431:TB927.1.1140
uniprot id: Q4GZA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM231 family.
messages: Membrane
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
messages: cilium membrane

185431:Tb927.7.7530
gene id: 185431:Tb927.7.7530
uniprot id: Q57TZ0
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.7.3350
gene id: 185431:Tb927.7.3350
uniprot id: Q57WF0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

185431:Tb927.6.5000
gene id: 185431:Tb927.6.5000
uniprot id: Q586H2
names: Similarity
messages: Belongs to the CDK5RAP3 family.

185431:Tb10.406.0470
gene id: 185431:Tb10.406.0470
uniprot id: Q389T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

185431:Tb09.354.0090
gene id: 185431:Tb09.354.0090
uniprot id: Q38G46
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.2.3580
gene id: 185431:Tb927.2.3580
uniprot id: Q586X9
names: Subcellular Location Annotation
messages: Nucleus

185431:Tb10.05.0110
gene id: 185431:Tb10.05.0110
uniprot id: Q388N2
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

185431:Tb10.70.6420
gene id: 185431:Tb10.70.6420
uniprot id: Q38C89
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

185431:Tb10.6k15.2330
gene id: 185431:Tb10.6k15.2330
uniprot id: Q38AE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.

185431:TB927.1.1240
gene id: 185431:TB927.1.1240
uniprot id: Q4GZ95
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

185431:Tb927.8.5860
gene id: 185431:Tb927.8.5860
uniprot id: Q57YI7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

185431:Tb927.8.4840
gene id: 185431:Tb927.8.4840
uniprot id: Q57UW8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb10.70.2070
gene id: 185431:Tb10.70.2070
uniprot id: Q38B88
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

185431:Tb927.7.5540
gene id: 185431:Tb927.7.5540
uniprot id: Q582G9
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

185431:Tb927.2.6320
gene id: 185431:Tb927.2.6320
uniprot id: Q586M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

185431:Tb927.7.7500
gene id: 185431:Tb927.7.7500
uniprot id: Q57TY7
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

185431:Tb09.211.2850
gene id: 185431:Tb09.211.2850
uniprot id: Q38DM0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

185431:Tb10.6k15.0560
gene id: 185431:Tb10.6k15.0560
uniprot id: Q38A01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPL family. K-HECT subfamily.
messages: nucleoplasm

185431:Tb927.7.3180
gene id: 185431:Tb927.7.3180
uniprot id: Q57YC8
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

185431:Tb09.160.1240
gene id: 185431:Tb09.160.1240
uniprot id: Q38FR2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

185431:Tb09.160.2260
gene id: 185431:Tb09.160.2260
uniprot id: Q38FG7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb10.26.0830
gene id: 185431:Tb10.26.0830
uniprot id: Q389M0
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

185431:Tb10.406.0080
gene id: 185431:Tb10.406.0080
uniprot id: Q389Q0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

185431:Tb927.8.6150
gene id: 185431:Tb927.8.6150
uniprot id: Q57YL6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

185431:Tb927.7.2660
gene id: 185431:Tb927.7.2660
uniprot id: Q57XK8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subunit
messages: Expressed at low levels in the bloodstream form (at protein level) (PubMed:31743541, PubMed:32532821). Expressed in the procyclic form (PubMed:31743541).
messages: Induced during differentiation of bloodstream form to procyclic form.
messages: Interacts (via MKT1-binding motif) with MKT1.
messages: RNA-binding protein involved in regulation of mRNA stability (PubMed:31743541). Promotes mRNA stabilization by recruiting MKT1 and PBP1 (By similarity). Stabilizes mRNA required for differentiation from the bloodstream form to the procyclic form, and maintenance of the procyclic form (PubMed:31743541). Stabilizes transcripts encoding membrane and mitochondrial proteins, including AQP1 and GPEET2 procyclin (PubMed:31743541).
messages: RNAi-mediated knockdown causes abnormal differentiation of the bloodstream form into the procyclic form, a reduction in the expression of several mRNA including differentiation protein PAD1, and premature death (PubMed:31743541). RNAi-mediated knockdown at the procyclic stage causes a decrease in growth rate (PubMed:31743541). Simultaneous RNAi-mediated knockdown of ZC3H20 and ZC3H21 at the bloodstream stage is lethal (PubMed:31743541). Simultaneous RNAi-mediated knockdown of ZC3H20 and ZC3H21 at the procyclic stage causes a severe growth defect and a shift towards a bloodstream form (PubMed:31743541).

185431:Tb927.6.3100
gene id: 185431:Tb927.6.3100
uniprot id: Q583M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT46 family.
messages: cilium
messages: cilium basal body

185431:Tb10.70.2180
gene id: 185431:Tb10.70.2180
uniprot id: Q38B99
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

185431:Tb09.211.3510
gene id: 185431:Tb09.211.3510
uniprot id: Q38DF6
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.

185431:Tb927.6.2510
gene id: 185431:Tb927.6.2510
uniprot id: Q584Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with the flavoprotein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.

185431:Tb927.8.570
gene id: 185431:Tb927.8.570
uniprot id: Q57YH3
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

185431:Tb09.211.1690
gene id: 185431:Tb09.211.1690
uniprot id: Q38DY5
names: Similarity
messages: Belongs to the p23/wos2 family.

185431:Tb10.6k15.3600
gene id: 185431:Tb10.6k15.3600
uniprot id: Q38AQ2
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

185431:TB927.1.1060
gene id: 185431:TB927.1.1060
uniprot id: Q4GZB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

185431:Tb09.v4.0006
gene id: 185431:Tb09.v4.0006
uniprot id: Q38G24
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

185431:Tb09.211.0930
gene id: 185431:Tb09.211.0930
uniprot id: Q38E63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

185431:Tb927.8.8090
gene id: 185431:Tb927.8.8090
uniprot id: Q57WM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:TB927.1.2100
gene id: 185431:TB927.1.2100
uniprot id: Q4GZ11
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb10.70.5920
gene id: 185431:Tb10.70.5920
uniprot id: Q38C51
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.7.450
gene id: 185431:Tb927.7.450
uniprot id: Q57U09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb10.70.5680
gene id: 185431:Tb10.70.5680
uniprot id: Q38C34
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

185431:Tb927.6.180
gene id: 185431:Tb927.6.180
uniprot id: Q57WZ9
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.5.2960
gene id: 185431:Tb927.5.2960
uniprot id: Q57ZX2
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

185431:Tb927.6.5130
gene id: 185431:Tb927.6.5130
uniprot id: Q586I4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: P1 and P2 exist as dimers at the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

185431:Tb927.5.110
gene id: 185431:Tb927.5.110
uniprot id: Q57XG7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.4.410
gene id: 185431:Tb927.4.410
uniprot id: Q57UT4
names: Similarity
messages: Belongs to the CNOT9 family.

185431:Tb927.8.1340
gene id: 185431:Tb927.8.1340
uniprot id: Q57VM1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

185431:Tb09.160.5650
gene id: 185431:Tb09.160.5650
uniprot id: Q38EI3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

185431:Tb927.8.7930
gene id: 185431:Tb927.8.7930
uniprot id: Q57U52
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.7.2590
gene id: 185431:Tb927.7.2590
uniprot id: Q57XL5
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

185431:Tb09.160.4620
gene id: 185431:Tb09.160.4620
uniprot id: Q38EU6
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

185431:Tb09.211.0540
gene id: 185431:Tb09.211.0540
uniprot id: Q38EA4
names: Similarity
messages: Belongs to the FBPase class 1 family.

185431:Tb10.70.4060
gene id: 185431:Tb10.70.4060
uniprot id: Q38BQ9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

185431:Tb09.211.3870
gene id: 185431:Tb09.211.3870
uniprot id: Q38DC2
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.7.970
gene id: 185431:Tb927.7.970
uniprot id: Q57VU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

185431:Tb927.4.1970
gene id: 185431:Tb927.4.1970
uniprot id: Q583J6
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.5.3050
gene id: 185431:Tb927.5.3050
uniprot id: Q57ZY1
names: Subcellular Location Annotation
messages: Nucleus

185431:Tb927.7.2370
gene id: 185431:Tb927.7.2370
uniprot id: Q57XN7
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

185431:Tb927.4.4510
gene id: 185431:Tb927.4.4510
uniprot id: Q583D6
names: Similarity
messages: Belongs to the PP2C family.

185431:Tb927.3.3270
gene id: 185431:Tb927.3.3270
uniprot id: D6XDN4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by AMP.
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Glycosome
messages: Homotetramer.

185431:Tb927.5.1810
gene id: 185431:Tb927.5.1810
uniprot id: Q57ZQ0
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

185431:Tb09.211.4155
gene id: 185431:Tb09.211.4155
uniprot id: Q38D93
names: Similarity
messages: Belongs to the YOS1 family.

185431:Tb10.406.0430
gene id: 185431:Tb10.406.0430
uniprot id: Q389T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.4.5300
gene id: 185431:Tb927.4.5300
uniprot id: Q580Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb927.5.880
gene id: 185431:Tb927.5.880
uniprot id: Q57W33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

185431:Tb09.244.2560
gene id: 185431:Tb09.244.2560
uniprot id: Q38CW6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.7.2250
gene id: 185431:Tb927.7.2250
uniprot id: Q57XP9
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

185431:Tb10.70.2470
gene id: 185431:Tb10.70.2470
uniprot id: Q38BC8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

185431:Tb09.160.0680
gene id: 185431:Tb09.160.0680
uniprot id: Q38FX1
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

185431:Tb10.6k15.3850
gene id: 185431:Tb10.6k15.3850
uniprot id: Q38AR9
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

185431:Tb09.160.3990
gene id: 185431:Tb09.160.3990
uniprot id: Q38F06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

185431:Tb927.2.6220
gene id: 185431:Tb927.2.6220
uniprot id: Q586N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

185431:Tb927.8.4280
gene id: 185431:Tb927.8.4280
uniprot id: Q57W07
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

185431:Tb927.5.470
gene id: 185431:Tb927.5.470
uniprot id: Q57VW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. RibJ family.
messages: Cell membrane
messages: Transporter involved in riboflavin (vitamin B2) uptake. Also transports FMN and FAD.

185431:Tb927.3.3630
gene id: 185431:Tb927.3.3630
uniprot id: Q57W99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

185431:Tb10.61.1820
gene id: 185431:Tb10.61.1820
uniprot id: Q388C4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

185431:Tb927.4.1870
gene id: 185431:Tb927.4.1870
uniprot id: Q583K6
names: Similarity
messages: Belongs to the PPP phosphatase family.

185431:Tb927.5.1310
gene id: 185431:Tb927.5.1310
uniprot id: Q57VD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

185431:Tb927.8.4390
gene id: 185431:Tb927.8.4390
uniprot id: Q57VZ6
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

185431:TB927.1.5100
gene id: 185431:TB927.1.5100
uniprot id: Q4GY71
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.8.130
gene id: 185431:Tb927.8.130
uniprot id: Q57XI8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.8.6900
gene id: 185431:Tb927.8.6900
uniprot id: Q57TS3
names: Similarity
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.

185431:Tb927.3.5100
gene id: 185431:Tb927.3.5100
uniprot id: Q580W5
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent 3'-5' DNA helicase, component of the general transcription factor IIH (TFIIH) core complex, involved in spliced leader RNA (SL RNA) gene transcription by RNA polymerase II (PubMed:17259543). TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB is required for promoter opening and promoter escape (By similarity).
messages: Belongs to the helicase family. RAD25/XPB subfamily.
messages: Component of the 7-subunit TFIIH core complex composed of XPB, XPD, SSL1, TFB1, TFB2, TFB4 and TFB5.

185431:Tb09.211.4700
gene id: 185431:Tb09.211.4700
uniprot id: Q38D40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Membrane

185431:Tb10.6k15.2190
gene id: 185431:Tb10.6k15.2190
uniprot id: Q38AD3
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

185431:Tb10.6k15.2510
gene id: 185431:Tb10.6k15.2510
uniprot id: Q38AG1
names: Similarity
messages: Belongs to the ATPase delta chain family.

185431:Tb927.3.4500
gene id: 185431:Tb927.3.4500
uniprot id: Q580J2
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Homodimer.

185431:Tb927.5.4420
gene id: 185431:Tb927.5.4420
uniprot id: Q57Z07
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

185431:Tb927.5.1090
gene id: 185431:Tb927.5.1090
uniprot id: Q57W54
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

185431:Tb09.211.3590
gene id: 185431:Tb09.211.3590
uniprot id: Q38DE9
names: Similarity
messages: Belongs to the FGGY kinase family.

185431:Tb927.6.1340
gene id: 185431:Tb927.6.1340
uniprot id: Q585B3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

185431:Tb09.160.3380
gene id: 185431:Tb09.160.3380
uniprot id: Q38F65
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

185431:Tb10.6k15.0050
gene id: 185431:Tb10.6k15.0050
uniprot id: Q389V4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

185431:Tb927.6.3160
gene id: 185431:Tb927.6.3160
uniprot id: Q584V9
names: Similarity
messages: Belongs to the SF3A3 family.

185431:Tb927.8.2850
gene id: 185431:Tb927.8.2850
uniprot id: Q57W87
names: Similarity
messages: Belongs to the CAF1 family.

185431:Tb927.5.4950
gene id: 185431:Tb927.5.4950
uniprot id: Q57XG6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.5.810
gene id: 185431:Tb927.5.810
uniprot id: Q57W26
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Expressed in the procyclic form and the bloodstream form at low levels.
messages: Induced during the response to misfolded or unfolded cytoplasmic proteins; including during thermal stress, sodium arsenite, or acidic pH (at protein level) (PubMed:23592996, PubMed:27002830). Not induced by endoplasmic reticulum stress (PubMed:27002830).
messages: Interacts (via MKT1-binding motif) with MKT1 (PubMed:23592996, PubMed:24470144). Interacts with PBP1 (via C-terminus); the interaction is direct (PubMed:23592996, PubMed:24470144).
messages: Phosphorylated at the N-terminus (PubMed:23592996, PubMed:27002830). CK1.2-dependent phosphorylation may lead to proteasome-dependent degradation of ZC3H11 in absence of stress (PubMed:27002830).
messages: RNA-binding protein involved in regulation of mRNA stability (PubMed:23592996). Binds AU-rich regions in the 3'-UTR of mRNAs and promotes their stabilization by recruiting a MKT1-containing complex (PubMed:23592996, PubMed:24470144). Stabilizes chaperone mRNAs during stress that causes an accumulation of misfolded or unfolded proteins in the cytoplasm (PubMed:23592996, PubMed:24470144, PubMed:27002830).
messages: RNAi-mediated knockdown in the bloodstream form is lethal and causes a reduction in chaperone mRNA levels in response to heat-induced stress (PubMed:23592996). RNAi-mediated knockdown in the procyclic form causes sensitivity to cytoplasmic protein folding stress (induced by high temperature, puromycin, arsenite, MG132 or ethanol), characterized by a reduction in chaperone mRNA levels (PubMed:23592996, PubMed:27002830).
messages: The zinc finger domain binds AU-rich regions in the 3'-UTR of mRNAs.

185431:Tb09.211.2870
gene id: 185431:Tb09.211.2870
uniprot id: Q38DL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

185431:Tb10.61.0570
gene id: 185431:Tb10.61.0570
uniprot id: Q387U0
names: Subcellular Location Annotation
messages: Nucleus

185431:Tb927.8.5230
gene id: 185431:Tb927.8.5230
uniprot id: Q57UJ5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

185431:Tb927.6.4740
gene id: 185431:Tb927.6.4740
uniprot id: Q587E0
names: Similarity
messages: Belongs to the XPO2/CSE1 family.

185431:Tb927.8.4640
gene id: 185431:Tb927.8.4640
uniprot id: Q57UY7
names: Similarity
messages: Belongs to the RIB43A family.

185431:Tb10.70.2720
gene id: 185431:Tb10.70.2720
uniprot id: Q4FKP8
names: Similarity
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.

185431:Tb927.3.2030
gene id: 185431:Tb927.3.2030
uniprot id: Q57ZA8
names: Similarity
messages: Belongs to the acylphosphatase family.

185431:Tb09.160.3500
gene id: 185431:Tb09.160.3500
uniprot id: Q38F55
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.70.5290
gene id: 185431:Tb10.70.5290
uniprot id: Q38C03
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

185431:Tb927.8.6160
gene id: 185431:Tb927.8.6160
uniprot id: Q57YL6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

185431:Tb09.160.4090
gene id: 185431:Tb09.160.4090
uniprot id: Q38EZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
messages: Homodimer.

185431:Tb927.6.3890
gene id: 185431:Tb927.6.3890
uniprot id: Q585Y7
names: Similarity
messages: Belongs to the activator 1 small subunits family.

185431:Tb927.7.270
gene id: 185431:Tb927.7.270
uniprot id: Q57U27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

185431:Tb927.4.4990
gene id: 185431:Tb927.4.4990
uniprot id: Q584K6
names: Similarity
messages: Belongs to the UQCRH/QCR6 family.

185431:Tb10.70.2465
gene id: 185431:Tb10.70.2465
uniprot id: Q38BC7
names: Similarity
messages: Belongs to the NOP10 family.

185431:Tb927.8.5590
gene id: 185431:Tb927.8.5590
uniprot id: Q57X23
names: Similarity
messages: Belongs to the SH3BGR family.

185431:Tb927.6.3800
gene id: 185431:Tb927.6.3800
uniprot id: Q585X3
names: Similarity
messages: Belongs to the heat shock protein 70 family.

185431:Tb927.8.7140
gene id: 185431:Tb927.8.7140
uniprot id: Q57YS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb927.6.520
gene id: 185431:Tb927.6.520
uniprot id: Q581G0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Major surface antigen of procyclic forms.
messages: Membrane

185431:Tb927.3.4200
gene id: 185431:Tb927.3.4200
uniprot id: Q580M2
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.8.6690
gene id: 185431:Tb927.8.6690
uniprot id: Q57TU4
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

185431:Tb927.8.5680
gene id: 185431:Tb927.8.5680
uniprot id: Q57X14
names: Similarity
messages: Belongs to the group II decarboxylase family.

185431:Tb927.5.4540
gene id: 185431:Tb927.5.4540
uniprot id: Q57X50
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.8.5310
gene id: 185431:Tb927.8.5310
uniprot id: Q57UK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

185431:Tb09.244.2280
gene id: 185431:Tb09.244.2280
uniprot id: Q38CU1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.8.2920
gene id: 185431:Tb927.8.2920
uniprot id: Q57W81
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

185431:Tb927.3.1120
gene id: 185431:Tb927.3.1120
uniprot id: Q57WZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

185431:Tb927.7.6290
gene id: 185431:Tb927.7.6290
uniprot id: Q57VI2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.7.460
gene id: 185431:Tb927.7.460
uniprot id: Q57U08
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
messages: Heterodimer of an alpha and a beta subunit.

185431:Tb927.5.130
gene id: 185431:Tb927.5.130
uniprot id: Q57XG9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb09.211.2550
gene id: 185431:Tb09.211.2550
uniprot id: Q38DQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

185431:Tb10.61.2040
gene id: 185431:Tb10.61.2040
uniprot id: Q388E0
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

185431:Tb927.7.5940
gene id: 185431:Tb927.7.5940
uniprot id: Q582K9
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.3.2210
gene id: 185431:Tb927.3.2210
uniprot id: Q582T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KIF-binding protein family.
messages: cytoskeleton

185431:Tb927.7.4160
gene id: 185431:Tb927.7.4160
uniprot id: Q57UP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

185431:Tb927.2.4550
gene id: 185431:Tb927.2.4550
uniprot id: Q586Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
messages: nucleolus

185431:Tb10.70.4600
gene id: 185431:Tb10.70.4600
uniprot id: Q38BU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

185431:Tb927.6.5740
gene id: 185431:Tb927.6.5740
uniprot id: Q583L3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.8.4410
gene id: 185431:Tb927.8.4410
uniprot id: Q57VZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Component of the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

185431:Tb927.4.3810
gene id: 185431:Tb927.4.3810
uniprot id: Q583H5
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

185431:Tb09.160.1570
gene id: 185431:Tb09.160.1570
uniprot id: Q38FN2
names: Similarity
messages: Belongs to the EAF6 family.

185431:TB927.1.3110
gene id: 185431:TB927.1.3110
uniprot id: Q4GYR2
names: Similarity
messages: Belongs to the SNAP family.

185431:Tb927.7.570
gene id: 185431:Tb927.7.570
uniprot id: Q57TZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

185431:Tb09.211.0190
gene id: 185431:Tb09.211.0190
uniprot id: Q38EE2
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins.

185431:Tb10.389.0110
gene id: 185431:Tb10.389.0110
uniprot id: Q388R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Nucleus

185431:Tb927.5.4770
gene id: 185431:Tb927.5.4770
uniprot id: Q57X38
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.3.1550
gene id: 185431:Tb927.3.1550
uniprot id: Q57XY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm

185431:Tb10.61.0700
gene id: 185431:Tb10.61.0700
uniprot id: Q387V0
names: Similarity
messages: Belongs to the WD repeat LST8 family.

185431:Tb10.70.1540
gene id: 185431:Tb10.70.1540
uniprot id: Q38B56
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

185431:Tb10.61.1030
gene id: 185431:Tb10.61.1030
uniprot id: Q387X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP11 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

185431:Tb10.6k15.2580
gene id: 185431:Tb10.6k15.2580
uniprot id: Q38AG7
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.6k15.2920
gene id: 185431:Tb10.6k15.2920
uniprot id: Q38AJ5
names: Subcellular Location Annotation
messages: cilium axoneme

185431:Tb09.211.3110
gene id: 185431:Tb09.211.3110
uniprot id: Q38DJ5
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

185431:Tb927.7.2840
gene id: 185431:Tb927.7.2840
uniprot id: Q57YA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.5.3970
gene id: 185431:Tb927.5.3970
uniprot id: Q57U69
names: Similarity
messages: Belongs to the adenylate kinase family.

185431:Tb927.2.5910
gene id: 185431:Tb927.2.5910
uniprot id: Q586C2
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

185431:Tb10.61.3050
gene id: 185431:Tb10.61.3050
uniprot id: Q388L2
names: Similarity
messages: Belongs to the tubulin--tyrosine ligase family.

185431:Tb10.6k15.1380
gene id: 185431:Tb10.6k15.1380
uniprot id: Q38A69
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

185431:Tb09.211.0430
gene id: 185431:Tb09.211.0430
uniprot id: Q38EB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

185431:Tb927.3.4860
gene id: 185431:Tb927.3.4860
uniprot id: Q582P9
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.4.450
gene id: 185431:Tb927.4.450
uniprot id: Q57UT0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

185431:Tb927.7.1320
gene id: 185431:Tb927.7.1320
uniprot id: Q57WR6
names: Similarity
messages: Belongs to the GroES chaperonin family.

185431:Tb927.7.190
gene id: 185431:Tb927.7.190
uniprot id: Q57U35
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

185431:Tb927.3.4190
gene id: 185431:Tb927.3.4190
uniprot id: Q580M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

185431:Tb927.4.5380
gene id: 185431:Tb927.4.5380
uniprot id: Q580P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP43 family.
messages: Flagellar protein involved in flagellum axoneme organization and function.
messages: flagellum
messages: flagellum axoneme

185431:Tb927.6.1320
gene id: 185431:Tb927.6.1320
uniprot id: Q585B1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

185431:Tb927.7.1130
gene id: 185431:Tb927.7.1130
uniprot id: D6XK31
names: Similarity
messages: Belongs to the glutathione peroxidase family.

185431:Tb927.5.890
gene id: 185431:Tb927.5.890
uniprot id: Q57W34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

185431:Tb927.7.4170
gene id: 185431:Tb927.7.4170
uniprot id: Q57UP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

185431:Tb927.3.2190
gene id: 185431:Tb927.3.2190
uniprot id: Q582T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal TPase family.
messages: Nucleus

185431:Tb927.3.830
gene id: 185431:Tb927.3.830
uniprot id: Q57WW6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Mitochondrion
messages: Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

185431:Tb10.6k15.1100
gene id: 185431:Tb10.6k15.1100
uniprot id: Q38A44
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.70.4090
gene id: 185431:Tb10.70.4090
uniprot id: Q38BR2
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.6.2600
gene id: 185431:Tb927.6.2600
uniprot id: Q584P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

185431:Tb927.8.1310
gene id: 185431:Tb927.8.1310
uniprot id: Q57VM4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

185431:Tb927.7.1450
gene id: 185431:Tb927.7.1450
uniprot id: Q57WQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

185431:Tb927.4.2120
gene id: 185431:Tb927.4.2120
uniprot id: Q584H5
names: Similarity
messages: Belongs to the WD repeat SEC13 family.

185431:Tb10.6k15.2500
gene id: 185431:Tb10.6k15.2500
uniprot id: Q38AG0
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

185431:Tb927.4.4960
gene id: 185431:Tb927.4.4960
uniprot id: Q584K9
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.8.3630
gene id: 185431:Tb927.8.3630
uniprot id: Q580Y3
names: Subcellular Location Annotation
messages: Membrane

185431:Tb09.211.1030
gene id: 185431:Tb09.211.1030
uniprot id: Q38E53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Bidirectional lipid inositolphosphotransferase capable of converting phosphatidylinositol (PI) and ceramide to inositol-phosphorylceramide (IPC) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphoinositol acceptors. Does not function strictly as a SM synthase. Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target (By similarity).
messages: Membrane

185431:Tb927.8.4950
gene id: 185431:Tb927.8.4950
uniprot id: Q57UV7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.6.1540
gene id: 185431:Tb927.6.1540
uniprot id: Q585Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

185431:Tb10.61.3140
gene id: 185431:Tb10.61.3140
uniprot id: Q388M1
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Inhibited by cyclin kinase 2 (CDK2) inhibitors, including GW8510.
messages: Was identified as a drug target for the treatment of African sleeping sickness. RNA interference leads to growth arrest and altered parasite morphology, demonstrating requirement for cell survival.

185431:Tb927.8.5460
gene id: 185431:Tb927.8.5460
uniprot id: Q57UL8
names: Function
names: Similarity
messages: Belongs to the calflagin family.
messages: May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form.

185431:Tb10.26.0670
gene id: 185431:Tb10.26.0670
uniprot id: Q389K8
names: Similarity
messages: Belongs to the IFT57 family.

185431:Tb927.4.3600
gene id: 185431:Tb927.4.3600
uniprot id: Q585J0
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

185431:Tb927.4.4470
gene id: 185431:Tb927.4.4470
uniprot id: Q583D2
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb10.6k15.0980
gene id: 185431:Tb10.6k15.0980
uniprot id: Q38A33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

185431:Tb09.244.2800
gene id: 185431:Tb09.244.2800
uniprot id: Q38CZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: cytoskeleton

185431:Tb927.3.2410
gene id: 185431:Tb927.3.2410
uniprot id: Q582V4
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.

185431:Tb927.4.2350
gene id: 185431:Tb927.4.2350
uniprot id: Q584F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

185431:Tb10.70.0020
gene id: 185431:Tb10.70.0020
uniprot id: Q38AT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

185431:Tb927.4.1830
gene id: 185431:Tb927.4.1830
uniprot id: Q583L0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3/UBA4 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3/UBA4 homolog.
messages: Cytoplasm

185431:TB927.1.1120
gene id: 185431:TB927.1.1120
uniprot id: Q4GZA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Probable methyltransferase required to silence rDNA.
messages: nucleolus

185431:Tb927.8.7560
gene id: 185431:Tb927.8.7560
uniprot id: Q57V77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

185431:TB927.1.2330
gene id: 185431:TB927.1.2330
uniprot id: Q4GYY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

185431:Tb927.4.4450
gene id: 185431:Tb927.4.4450
uniprot id: Q583D0
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.3.3340
gene id: 185431:Tb927.3.3340
uniprot id: Q57V52
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

185431:Tb927.3.3310
gene id: 185431:Tb927.3.3310
uniprot id: Q57V55
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

185431:Tb09.160.3730
gene id: 185431:Tb09.160.3730
uniprot id: Q38F32
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

185431:Tb927.7.1690
gene id: 185431:Tb927.7.1690
uniprot id: Q57V41
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent protein deacetylase, which is involved in repression of RNA polymerase I-mediated expression immediately adjacent to telomeres. It is however not involved in antigenic variation and subtelomeric variant surface glycoprotein (VSG) gene silencing. Plays a role in DNA damage response. Also has ADP-ribosylation activity in vitro.
messages: Nucleus
messages: telomere

185431:Tb10.70.5100
gene id: 185431:Tb10.70.5100
uniprot id: Q38BY8
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

185431:Tb927.8.1990
gene id: 185431:Tb927.8.1990
uniprot id: D6XKT6
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

185431:Tb927.8.2050
gene id: 185431:Tb927.8.2050
uniprot id: Q581X7
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

185431:Tb927.4.1790
gene id: 185431:Tb927.4.1790
uniprot id: Q581Q2
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

185431:Tb927.8.5580
gene id: 185431:Tb927.8.5580
uniprot id: Q57X24
names: Similarity
messages: Belongs to the VPS13 family.

185431:Tb927.8.460
gene id: 185431:Tb927.8.460
uniprot id: Q57XI6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.05.0190
gene id: 185431:Tb10.05.0190
uniprot id: Q388Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

185431:Tb927.5.2780
gene id: 185431:Tb927.5.2780
uniprot id: D6XGL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

185431:Tb10.70.3280
gene id: 185431:Tb10.70.3280
uniprot id: Q38BK0
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

185431:Tb09.244.0050
gene id: 185431:Tb09.244.0050
uniprot id: Q38CM7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.70.2140
gene id: 185431:Tb10.70.2140
uniprot id: Q38B94
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

185431:Tb927.7.6040
gene id: 185431:Tb927.7.6040
uniprot id: Q57VK7
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:TB927.1.3300
gene id: 185431:TB927.1.3300
uniprot id: Q4GYP3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

185431:Tb09.211.0870
gene id: 185431:Tb09.211.0870
uniprot id: Q38E68
names: Similarity
messages: Belongs to the PPR family. P subfamily.

185431:Tb927.7.3110
gene id: 185431:Tb927.7.3110
uniprot id: Q57YC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

185431:Tb10.70.5650
gene id: 185431:Tb10.70.5650
uniprot id: P86934
uniprot id: P86939
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Phosphatidylethanolamine (PE) is a direct precursor of the ethanolamine-phosphoglycerol (EPG) moiety.
messages: The Kennedy pathway is the major route for phosphatidylethanolamine (PE) synthesis, as shown by reduced levels after using RNAi against the first two enzymes of the Kennedy pathway.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

185431:Tb927.7.3680
gene id: 185431:Tb927.7.3680
uniprot id: Q57WI3
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

185431:Tb927.7.1000
gene id: 185431:Tb927.7.1000
uniprot id: Q57VU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: Monomer.
messages: Required for the maintenance of mitochondrial (kinetoplast) genome stability. Essential for cell viability. Has probably no helicase activity, missing at least two of seven conserved helicase motifs.
messages: kinetoplast

185431:Tb10.70.0960
gene id: 185431:Tb10.70.0960
uniprot id: Q38B10
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb10.70.5460
gene id: 185431:Tb10.70.5460
uniprot id: Q38C17
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

185431:Tb10.70.0010
gene id: 185431:Tb10.70.0010
uniprot id: Q38AT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

185431:Tb927.2.4890
gene id: 185431:Tb927.2.4890
uniprot id: Q586R9
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

185431:Tb927.6.2920
gene id: 185431:Tb927.6.2920
uniprot id: Q583P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

185431:Tb10.61.2880
gene id: 185431:Tb10.61.2880
uniprot id: Q388J9
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

185431:Tb927.7.3280
gene id: 185431:Tb927.7.3280
uniprot id: Q57WE3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

185431:Tb927.5.4250
gene id: 185431:Tb927.5.4250
uniprot id: Q57Z31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the histone H4 family.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb10.6k15.1940
gene id: 185431:Tb10.6k15.1940
uniprot id: Q38AB2
names: Similarity
messages: Belongs to the VPS54 family.

185431:Tb09.160.0840
gene id: 185431:Tb09.160.0840
uniprot id: Q38FV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

185431:Tb927.3.3590
gene id: 185431:Tb927.3.3590
uniprot id: Q57W95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: nucleolus

185431:Tb10.61.2440
gene id: 185431:Tb10.61.2440
uniprot id: Q388G9
names: Subcellular Location Annotation
messages: nucleolus

185431:Tb10.70.7040
gene id: 185431:Tb10.70.7040
uniprot id: Q38CD3
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.6.3550
gene id: 185431:Tb927.6.3550
uniprot id: Q584Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

185431:Tb10.26.0940
gene id: 185431:Tb10.26.0940
uniprot id: Q389M9
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

185431:Tb927.8.2670
gene id: 185431:Tb927.8.2670
uniprot id: Q57XC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

185431:Tb927.4.5270
gene id: 185431:Tb927.4.5270
uniprot id: Q584H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb927.6.2700
gene id: 185431:Tb927.6.2700
uniprot id: D6XI03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.

185431:Tb10.70.7050
gene id: 185431:Tb10.70.7050
uniprot id: Q38CD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.

185431:Tb10.6k15.2770
gene id: 185431:Tb10.6k15.2770
uniprot id: Q38AI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus

185431:Tb10.70.4800
gene id: 185431:Tb10.70.4800
uniprot id: Q57XX0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

185431:Tb09.244.1570
gene id: 185431:Tb09.244.1570
uniprot id: Q38CQ1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.7.280
gene id: 185431:Tb927.7.280
uniprot id: Q57U26
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

185431:Tb927.8.5250
gene id: 185431:Tb927.8.5250
uniprot id: Q57UJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

185431:Tb927.6.5550
gene id: 185431:Tb927.6.5550
uniprot id: Q583L4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.6k15.0540
gene id: 185431:Tb10.6k15.0540
uniprot id: Q389Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

185431:Tb927.4.2630
gene id: 185431:Tb927.4.2630
uniprot id: Q584C4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.
messages: nucleolus

185431:Tb10.70.1370
gene id: 185431:Tb10.70.1370
uniprot id: Q38B42
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

185431:Tb10.70.1490
gene id: 185431:Tb10.70.1490
uniprot id: Q38B52
names: Similarity
messages: Belongs to the MEMO1 family.

185431:Tb09.160.2110
gene id: 185431:Tb09.160.2110
uniprot id: Q38FI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the NTC complex (or PRP19-associated complex) (By similarity). The NTC complex associates with the spliceosome after the release of the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex reminiscent of a late-stage spliceosome (By similarity). Associates specifically with U5-containing snRNPs.
messages: Belongs to the CWC21 family.
messages: Cytoplasm
messages: Essential protein involved in pre-mRNA cis- and trans-splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate.
messages: Nucleus

185431:Tb10.70.0140
gene id: 185431:Tb10.70.0140
uniprot id: Q38AU3
names: Similarity
messages: Belongs to the DEAD box helicase family.

185431:Tb09.160.5330
gene id: 185431:Tb09.160.5330
uniprot id: Q38EL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:TB927.1.1400
gene id: 185431:TB927.1.1400
uniprot id: Q4GZ79
names: Similarity
messages: Belongs to the OPI10 family.

185431:Tb927.3.1790
gene id: 185431:Tb927.3.1790
uniprot id: Q57ZD2
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

185431:Tb927.6.3750
gene id: 185431:Tb927.6.3750
uniprot id: Q585X3
names: Similarity
messages: Belongs to the heat shock protein 70 family.

185431:Tb927.4.3590
gene id: 185431:Tb927.4.3590
uniprot id: Q585J1
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

185431:Tb10.61.2930
gene id: 185431:Tb10.61.2930
uniprot id: Q388K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCB family.
messages: Cytoplasm

185431:Tb927.5.4170
gene id: 185431:Tb927.5.4170
uniprot id: Q57Z31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the histone H4 family.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.6.1010
gene id: 185431:Tb927.6.1010
uniprot id: Q585F0
names: Similarity
messages: Belongs to the peptidase C1 family.

185431:Tb10.70.7480
gene id: 185431:Tb10.70.7480
uniprot id: Q38CG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

185431:Tb927.2.2500
gene id: 185431:Tb927.2.2500
uniprot id: Q586M1
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.8.1600
gene id: 185431:Tb927.8.1600
uniprot id: Q580G3
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

185431:Tb10.100.0120
gene id: 185431:Tb10.100.0120
uniprot id: Q38CL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.

185431:Tb927.6.1630
gene id: 185431:Tb927.6.1630
uniprot id: Q585P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

185431:Tb927.6.4880
gene id: 185431:Tb927.6.4880
uniprot id: Q586G3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

185431:Tb927.6.1970
gene id: 185431:Tb927.6.1970
uniprot id: Q585L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NCBP2 family.
messages: Nucleus

185431:TB927.1.1150
gene id: 185431:TB927.1.1150
uniprot id: Q4GZA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

185431:Tb09.160.3480
gene id: 185431:Tb09.160.3480
uniprot id: Q38F57
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.3.1110
gene id: 185431:Tb927.3.1110
uniprot id: Q57WZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

185431:Tb927.5.3810
gene id: 185431:Tb927.5.3810
uniprot id: Q57U85
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

185431:Tb09.244.2730
gene id: 185431:Tb09.244.2730
uniprot id: Q38CY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

185431:Tb09.244.0200
gene id: 185431:Tb09.244.0200
uniprot id: Q38CN1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb09.211.4920
gene id: 185431:Tb09.211.4920
uniprot id: Q38D18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: cytoskeleton

185431:Tb927.7.2520
gene id: 185431:Tb927.7.2520
uniprot id: Q57XM2
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

185431:Tb09.211.2640
gene id: 185431:Tb09.211.2640
uniprot id: Q38DP2
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

185431:Tb927.8.6760
gene id: 185431:Tb927.8.6760
uniprot id: Q57TT7
names: Similarity
messages: Belongs to the TCTP family.

185431:Tb09.211.3050
gene id: 185431:Tb09.211.3050
uniprot id: Q38DK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

185431:Tb09.211.1000
gene id: 185431:Tb09.211.1000
uniprot id: Q38E56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target (By similarity).
messages: Golgi apparatus membrane

185431:Tb927.6.510
gene id: 185431:Tb927.6.510
uniprot id: Q581F9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Major surface antigen of procyclic forms.
messages: Membrane

185431:TB927.1.2110
gene id: 185431:TB927.1.2110
uniprot id: Q4GZ10
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb10.70.0550
gene id: 185431:Tb10.70.0550
uniprot id: Q38AX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.
messages: Monomer.

185431:Tb927.6.5450
gene id: 185431:Tb927.6.5450
uniprot id: Q583L5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:TB927.1.1990
gene id: 185431:TB927.1.1990
uniprot id: Q4GZ20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus
messages: Required for pre-mRNA splicing.

185431:Tb927.2.5270
gene id: 185431:Tb927.2.5270
uniprot id: Q585U4
names: Similarity
messages: Belongs to the dynein heavy chain family.

185431:Tb09.211.4513
gene id: 185431:Tb09.211.4513
uniprot id: Q38D58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KMP-11 family.
messages: Monomer.
messages: cytoskeleton

185431:Tb927.8.6190
gene id: 185431:Tb927.8.6190
uniprot id: Q57YM0
names: Similarity
messages: Belongs to the BolA/IbaG family.

185431:Tb10.70.1720
gene id: 185431:Tb10.70.1720
uniprot id: Q38B68
names: Similarity
messages: Belongs to the dynein heavy chain family.

185431:Tb927.2.4720
gene id: 185431:Tb927.2.4720
uniprot id: Q586R8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

185431:Tb09.211.1400
gene id: 185431:Tb09.211.1400
uniprot id: Q38E15
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.7.4000
gene id: 185431:Tb927.7.4000
uniprot id: Q57UN0
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

185431:Tb10.70.2520
gene id: 185431:Tb10.70.2520
uniprot id: Q38BD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

185431:Tb927.2.2460
gene id: 185431:Tb927.2.2460
uniprot id: Q586L8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

185431:Tb927.8.5260
gene id: 185431:Tb927.8.5260
uniprot id: Q57UJ8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

185431:Tb927.6.560
gene id: 185431:Tb927.6.560
uniprot id: D6XHE1
names: Similarity
messages: Belongs to the peptidase C1 family.

185431:Tb10.61.2200
gene id: 185431:Tb10.61.2200
uniprot id: Q388F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
messages: Endoplasmic reticulum membrane
messages: Probable GTP-binding protein that may be involved in cell development.

185431:Tb927.4.4680
gene id: 185431:Tb927.4.4680
uniprot id: Q583F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS3/PSF3 family.
messages: Nucleus

185431:Tb927.5.3020
gene id: 185431:Tb927.5.3020
uniprot id: Q57ZX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

185431:Tb927.7.6000
gene id: 185431:Tb927.7.6000
uniprot id: Q57VL1
names: Subcellular Location Annotation
messages: Membrane

185431:Tb09.211.1695
gene id: 185431:Tb09.211.1695
uniprot id: Q38DY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

185431:Tb927.5.900
gene id: 185431:Tb927.5.900
uniprot id: Q57W35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

185431:Tb927.4.4340
gene id: 185431:Tb927.4.4340
uniprot id: Q57Y38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP300 family.
messages: Cytoplasm

185431:Tb927.3.3920
gene id: 185431:Tb927.3.3920
uniprot id: Q57WC8
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

185431:Tb927.8.7890
gene id: 185431:Tb927.8.7890
uniprot id: Q57U55
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.4.2730
gene id: 185431:Tb927.4.2730
uniprot id: D6XFK9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb10.389.1850
gene id: 185431:Tb10.389.1850
uniprot id: Q389E9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

185431:Tb927.8.2910
gene id: 185431:Tb927.8.2910
uniprot id: Q57W82
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

185431:Tb10.406.0520
gene id: 185431:Tb10.406.0520
uniprot id: Q389T8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Trypanothione is the parasite analog of glutathione; this enzyme is the equivalent of glutathione reductase.

185431:Tb927.6.2340
gene id: 185431:Tb927.6.2340
uniprot id: Q584S2
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

185431:Tb10.70.4155
gene id: 185431:Tb10.70.4155
uniprot id: Q38BR9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

185431:Tb09.160.0570
gene id: 185431:Tb09.160.0570
uniprot id: Q38FY2
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

185431:Tb09.211.2580
gene id: 185431:Tb09.211.2580
uniprot id: Q38DP8
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

185431:Tb927.4.560
gene id: 185431:Tb927.4.560
uniprot id: D6XEZ2
names: Similarity
messages: Belongs to the dynein heavy chain family.

185431:TB927.1.5060
gene id: 185431:TB927.1.5060
uniprot id: Q4GY74
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.5.2140
gene id: 185431:Tb927.5.2140
uniprot id: Q582F1
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

185431:Tb927.4.5580
gene id: 185431:Tb927.4.5580
uniprot id: Q580N9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.61.0060
gene id: 185431:Tb10.61.0060
uniprot id: Q387P6
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.4.2290
gene id: 185431:Tb927.4.2290
uniprot id: Q584F8
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

185431:Tb927.8.8100
gene id: 185431:Tb927.8.8100
uniprot id: Q57WM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb09.211.1320
gene id: 185431:Tb09.211.1320
uniprot id: Q38E23
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

185431:Tb927.7.4710
gene id: 185431:Tb927.7.4710
uniprot id: Q57X87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

185431:Tb927.7.1060
gene id: 185431:Tb927.7.1060
uniprot id: Q57VV2
names: Subcellular Location Annotation
messages: Nucleus

185431:Tb927.5.3830
gene id: 185431:Tb927.5.3830
uniprot id: Q57U83
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
messages: Cytoplasm
messages: Homodimer.

185431:Tb927.7.950
gene id: 185431:Tb927.7.950
uniprot id: Q57VU1
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.5.1730
gene id: 185431:Tb927.5.1730
uniprot id: D6XGB1
uniprot id: Q57ZP2
names: Similarity
messages: Belongs to the protease inhibitor I11 (ecotin) family.

185431:Tb927.4.4440
gene id: 185431:Tb927.4.4440
uniprot id: Q583C9
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb10.70.7020
gene id: 185431:Tb10.70.7020
uniprot id: Q38CD1
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

185431:Tb927.3.5030
gene id: 185431:Tb927.3.5030
uniprot id: Q582N4
names: Subcellular Location Annotation
messages: Nucleus

185431:Tb927.6.4180
gene id: 185431:Tb927.6.4180
uniprot id: Q586B6
names: Similarity
messages: Belongs to the FUN14 family.

185431:Tb927.4.3680
gene id: 185431:Tb927.4.3680
uniprot id: Q585I2
names: Similarity
messages: Belongs to the PP2C family.

185431:Tb927.8.7110
gene id: 185431:Tb927.8.7110
uniprot id: Q57YR8
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb09.211.2660
gene id: 185431:Tb09.211.2660
uniprot id: Q38DN8
names: Similarity
messages: Belongs to the cullin family.

185431:Tb927.7.6070
gene id: 185431:Tb927.7.6070
uniprot id: Q57VK4
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb10.70.4880
gene id: 185431:Tb10.70.4880
uniprot id: Q38BW8
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

185431:Tb927.7.5020
gene id: 185431:Tb927.7.5020
uniprot id: Q57ZI7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL19 family.

185431:Tb10.70.0110
gene id: 185431:Tb10.70.0110
uniprot id: Q38AU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

185431:Tb927.5.3120
gene id: 185431:Tb927.5.3120
uniprot id: Q57Z81
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

185431:Tb927.7.4490
gene id: 185431:Tb927.7.4490
uniprot id: Q57X65
names: Similarity
messages: Belongs to the SEC5 family.

185431:TB927.1.2380
gene id: 185431:TB927.1.2380
uniprot id: Q4GYY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

185431:Tb927.8.720
gene id: 185431:Tb927.8.720
uniprot id: Q57YF8
names: Similarity
messages: Belongs to the MIP18 family.

185431:Tb10.6k15.3280
gene id: 185431:Tb10.6k15.3280
uniprot id: Q38AM4
names: Similarity
messages: Belongs to the PHF5 family.

185431:Tb10.70.1310
gene id: 185431:Tb10.70.1310
uniprot id: Q38B36
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

185431:Tb09.211.0090
gene id: 185431:Tb09.211.0090
uniprot id: Q38EF2
names: Similarity
messages: Belongs to the TRAPPC13 family.

185431:Tb09.160.1250
gene id: 185431:Tb09.160.1250
uniprot id: Q38FR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Nucleus

185431:Tb10.70.7470
gene id: 185431:Tb10.70.7470
uniprot id: Q38CG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family.
messages: Nucleus

185431:Tb927.3.4230
gene id: 185431:Tb927.3.4230
uniprot id: Q580L9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:TB927.1.2510
gene id: 185431:TB927.1.2510
uniprot id: Q4GYX7
names: Similarity
messages: Belongs to the histone H3 family.

185431:Tb10.6k15.2450
gene id: 185431:Tb10.6k15.2450
uniprot id: Q38AF6
names: Similarity
messages: Belongs to the UFL1 family.

185431:Tb927.3.3710
gene id: 185431:Tb927.3.3710
uniprot id: Q57WA7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb09.160.5440
gene id: 185431:Tb09.160.5440
uniprot id: Q38EK4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb09.211.0470
gene id: 185431:Tb09.211.0470
uniprot id: Q38EB2
names: Similarity
messages: Belongs to the TCF25 family.

185431:Tb927.5.3760
gene id: 185431:Tb927.5.3760
uniprot id: Q57U90
names: Similarity
messages: Belongs to the TOP6A family.

185431:Tb927.5.3930
gene id: 185431:Tb927.5.3930
uniprot id: Q57U73
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.389.1430
gene id: 185431:Tb10.389.1430
uniprot id: Q389B2
names: Similarity
messages: Belongs to the asfivirus helicase A859L family.

185431:Tb927.3.1130
gene id: 185431:Tb927.3.1130
uniprot id: Q57WZ4
names: Similarity
messages: Belongs to the DNA polymerase delta/II small subunit family.

185431:Tb927.2.5850
gene id: 185431:Tb927.2.5850
uniprot id: Q586C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

185431:Tb927.6.1330
gene id: 185431:Tb927.6.1330
uniprot id: Q585B4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.7.2900
gene id: 185431:Tb927.7.2900
uniprot id: Q57YA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb10.70.0750
gene id: 185431:Tb10.70.0750
uniprot id: Q38AZ4
names: Similarity
messages: Belongs to the peptidase M76 family.

185431:Tb10.61.1880
gene id: 185431:Tb10.61.1880
uniprot id: Q388C6
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.3.800
gene id: 185431:Tb927.3.800
uniprot id: Q57WW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCC1 family.
messages: Membrane

185431:Tb927.7.4940
gene id: 185431:Tb927.7.4940
uniprot id: Q57XB0
names: Similarity
messages: Belongs to the peptidase S9A family.

185431:Tb10.70.3220
gene id: 185431:Tb10.70.3220
uniprot id: Q38BJ5
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

185431:Tb10.61.0810
gene id: 185431:Tb10.61.0810
uniprot id: Q387V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

185431:Tb10.6k15.3820
gene id: 185431:Tb10.6k15.3820
uniprot id: Q4FKJ2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.

185431:Tb927.5.2850
gene id: 185431:Tb927.5.2850
uniprot id: Q57ZW1
names: Similarity
messages: Belongs to the dpy-30 family.

185431:Tb10.v4.0025
gene id: 185431:Tb10.v4.0025
uniprot id: Q387P1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.8.7430
gene id: 185431:Tb927.8.7430
uniprot id: Q57YU5
names: Similarity
messages: Belongs to the UQCRH/QCR6 family.

185431:Tb927.7.2420
gene id: 185431:Tb927.7.2420
uniprot id: Q57XN2
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

185431:Tb927.8.3130
gene id: 185431:Tb927.8.3130
uniprot id: Q57W60
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

185431:Tb927.6.2110
gene id: 185431:Tb927.6.2110
uniprot id: Q584U5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS30 family.

185431:Tb927.6.4350
gene id: 185431:Tb927.6.4350
uniprot id: Q587A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

185431:Tb927.3.5440
gene id: 185431:Tb927.3.5440
uniprot id: Q580T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

185431:Tb927.5.4180
gene id: 185431:Tb927.5.4180
uniprot id: Q57Z31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the histone H4 family.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb10.61.0690
gene id: 185431:Tb10.61.0690
uniprot id: Q387U9
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

185431:Tb10.61.2745
gene id: 185431:Tb10.61.2745
uniprot id: Q388J2
names: Function
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

185431:Tb927.3.440
gene id: 185431:Tb927.3.440
uniprot id: Q57TR4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.5.3860
gene id: 185431:Tb927.5.3860
uniprot id: Q57U80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin polyglutamylase family.
messages: cilium basal body

185431:Tb10.61.1330
gene id: 185431:Tb10.61.1330
uniprot id: Q387Z3
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

185431:Tb927.3.5520
gene id: 185431:Tb927.3.5520
uniprot id: Q580S3
names: Similarity
messages: Belongs to the proteasome subunit S2 family.

185431:Tb927.6.2400
gene id: 185431:Tb927.6.2400
uniprot id: Q584R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

185431:Tb10.05.0100
gene id: 185431:Tb10.05.0100
uniprot id: Q388N3
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.5.550
gene id: 185431:Tb927.5.550
uniprot id: Q57VV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

185431:Tb09.211.0510
gene id: 185431:Tb09.211.0510
uniprot id: Q38EA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCO1/2 family.
messages: Mitochondrion inner membrane

185431:Tb09.160.0480
gene id: 185431:Tb09.160.0480
uniprot id: Q38FZ2
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

185431:Tb10.70.3870
gene id: 185431:Tb10.70.3870
uniprot id: Q38BP4
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.

185431:Tb927.4.5280
gene id: 185431:Tb927.4.5280
uniprot id: Q584H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb927.7.2080
gene id: 185431:Tb927.7.2080
uniprot id: Q57V03
names: Similarity
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.

185431:Tb927.5.2080
gene id: 185431:Tb927.5.2080
uniprot id: Q57ZS7
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

185431:Tb927.2.4580
gene id: 185431:Tb927.2.4580
uniprot id: Q586Q9
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

185431:Tb927.3.2870
gene id: 185431:Tb927.3.2870
uniprot id: Q57ZM5
names: Similarity
messages: Belongs to the multicopper oxidase family.

185431:Tb927.2.2440
gene id: 185431:Tb927.2.2440
uniprot id: Q586L6
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

185431:Tb927.4.3550
gene id: 185431:Tb927.4.3550
uniprot id: Q585J5
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

185431:Tb927.4.4380
gene id: 185431:Tb927.4.4380
uniprot id: Q57Y42
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.7.5260
gene id: 185431:Tb927.7.5260
uniprot id: Q57ZG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

185431:Tb09.211.1190
gene id: 185431:Tb09.211.1190
uniprot id: Q38E36
names: Similarity
messages: Belongs to the MCM family.

185431:Tb927.4.3280
gene id: 185431:Tb927.4.3280
uniprot id: Q584A5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.3.5620
gene id: 185431:Tb927.3.5620
uniprot id: Q580R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

185431:Tb927.4.3950
gene id: 185431:Tb927.4.3950
uniprot id: Q57XZ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:TB927.1.1560
gene id: 185431:TB927.1.1560
uniprot id: Q4GZ63
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

185431:Tb10.26.0220
gene id: 185431:Tb10.26.0220
uniprot id: Q389H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

185431:Tb927.7.430
gene id: 185431:Tb927.7.430
uniprot id: Q57U11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb927.2.3720
gene id: 185431:Tb927.2.3720
uniprot id: Q586X5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

185431:Tb927.5.2130
gene id: 185431:Tb927.5.2130
uniprot id: Q57ZT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Nucleus

185431:Tb927.8.700
gene id: 185431:Tb927.8.700
uniprot id: Q57YG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability.
messages: Monomer.
messages: kinetoplast

185431:Tb10.61.1710
gene id: 185431:Tb10.61.1710
uniprot id: Q388B5
names: Subcellular Location Annotation
messages: Cell membrane

185431:Tb927.4.1640
gene id: 185431:Tb927.4.1640
uniprot id: Q581R7
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb927.3.3610
gene id: 185431:Tb927.3.3610
uniprot id: Q57W97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Cytoplasm

185431:Tb927.6.4870
gene id: 185431:Tb927.6.4870
uniprot id: Q586F9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

185431:TB927.1.580
gene id: 185431:TB927.1.580
uniprot id: Q4GZF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

185431:Tb927.4.4250
gene id: 185431:Tb927.4.4250
uniprot id: Q57Y29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb10.05.0220
gene id: 185431:Tb10.05.0220
uniprot id: Q383V8
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

185431:Tb09.211.3540
gene id: 185431:Tb09.211.3540
uniprot id: Q38DF3
names: Similarity
messages: Belongs to the FGGY kinase family.

185431:Tb10.389.1450
gene id: 185431:Tb10.389.1450
uniprot id: Q389B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb927.8.6580
gene id: 185431:Tb927.8.6580
uniprot id: Q57TV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

185431:Tb10.6k15.3080
gene id: 185431:Tb10.6k15.3080
uniprot id: Q38AK7
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

185431:Tb927.6.5240
gene id: 185431:Tb927.6.5240
uniprot id: Q583L8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.70.1740
gene id: 185431:Tb10.70.1740
uniprot id: Q38B69
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

185431:Tb09.211.3740
gene id: 185431:Tb09.211.3740
uniprot id: Q38DD5
names: Similarity
messages: Belongs to the polyprenol kinase family.

185431:Tb09.160.4200
gene id: 185431:Tb09.160.4200
uniprot id: Q38EY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: P1 and P2 exist as dimers at the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

185431:Tb10.61.3010
gene id: 185431:Tb10.61.3010
uniprot id: Q388K9
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.3.2400
gene id: 185431:Tb927.3.2400
uniprot id: Q582V3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

185431:Tb927.7.5000
gene id: 185431:Tb927.7.5000
uniprot id: Q57ZI7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL19 family.

185431:Tb927.7.2360
gene id: 185431:Tb927.7.2360
uniprot id: Q57XN8
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

185431:Tb09.244.2850
gene id: 185431:Tb09.244.2850
uniprot id: Q38D00
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

185431:Tb927.6.1360
gene id: 185431:Tb927.6.1360
uniprot id: Q585B1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

185431:Tb10.70.3930
gene id: 185431:Tb10.70.3930
uniprot id: Q38BP7
names: Similarity
messages: Belongs to the AAA ATPase family.

185431:Tb927.3.190
gene id: 185431:Tb927.3.190
uniprot id: Q57TR8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.7.6080
gene id: 185431:Tb927.7.6080
uniprot id: Q57VK3
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:TB927.1.4140
gene id: 185431:TB927.1.4140
uniprot id: Q4GYG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBS5 family.
messages: Membrane
messages: centriolar satellite
messages: cilium membrane

185431:Tb927.7.410
gene id: 185431:Tb927.7.410
uniprot id: Q57U13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb09.160.5600
gene id: 185431:Tb09.160.5600
uniprot id: Q38EI8
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

185431:Tb10.6k15.2050
gene id: 185431:Tb10.6k15.2050
uniprot id: Q38AC1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

185431:Tb927.2.4610
gene id: 185431:Tb927.2.4610
uniprot id: Q586R1
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

185431:Tb927.6.1960
gene id: 185431:Tb927.6.1960
uniprot id: Q585L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG14 family.
messages: Belongs to the glycosyltransferase 28 family.
messages: Membrane
messages: Nucleus membrane

185431:Tb927.3.4890
gene id: 185431:Tb927.3.4890
uniprot id: Q582P6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.
messages: Component of a multi-subunit COQ enzyme complex.
messages: Mitochondrion inner membrane

185431:TB927.1.2530
gene id: 185431:TB927.1.2530
uniprot id: Q4GYX7
names: Similarity
messages: Belongs to the histone H3 family.

185431:Tb927.3.2150
gene id: 185431:Tb927.3.2150
uniprot id: Q57Z96
names: Similarity
messages: Belongs to the PP2C family.

185431:Tb927.3.1510
gene id: 185431:Tb927.3.1510
uniprot id: Q57XY4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.8.3200
gene id: 185431:Tb927.8.3200
uniprot id: Q57YZ3
names: Similarity
messages: Belongs to the RICTOR family.

185431:Tb927.8.5770
gene id: 185431:Tb927.8.5770
uniprot id: Q57X05
names: Similarity
messages: Belongs to the ELP3 family.

185431:Tb09.244.2790
gene id: 185431:Tb09.244.2790
uniprot id: Q38CZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: nucleolus

185431:Tb927.6.1950
gene id: 185431:Tb927.6.1950
uniprot id: Q585L6
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

185431:Tb927.3.1950
gene id: 185431:Tb927.3.1950
uniprot id: Q57ZB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

185431:Tb09.211.1580
gene id: 185431:Tb09.211.1580
uniprot id: Q38DZ8
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.5.4300
gene id: 185431:Tb927.5.4300
uniprot id: Q57Z19
names: Similarity
messages: Belongs to the peptidase S9A family.

185431:Tb927.7.3070
gene id: 185431:Tb927.7.3070
uniprot id: Q57YB7
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.6k15.0360
gene id: 185431:Tb10.6k15.0360
uniprot id: Q389Y4
names: Subcellular Location Annotation
messages: nucleolus

185431:Tb927.8.3830
gene id: 185431:Tb927.8.3830
uniprot id: Q581A3
names: Similarity
messages: Belongs to the DEAD box helicase family.

185431:Tb10.61.1360
gene id: 185431:Tb10.61.1360
uniprot id: Q387Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

185431:Tb927.8.2520
gene id: 185431:Tb927.8.2520
uniprot id: Q57XD7
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

185431:Tb927.4.830
gene id: 185431:Tb927.4.830
uniprot id: Q580B1
names: Similarity
messages: Belongs to the PET191 family.

185431:Tb927.3.3200
gene id: 185431:Tb927.3.3200
uniprot id: Q57V66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0602 family.
messages: centrosome

185431:Tb927.7.5060
gene id: 185431:Tb927.7.5060
uniprot id: Q57ZI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Membrane

185431:Tb927.6.3420
gene id: 185431:Tb927.6.3420
uniprot id: Q584Y2
names: Similarity
messages: Belongs to the Iojap/RsfS family.

185431:Tb09.244.1410
gene id: 185431:Tb09.244.1410
uniprot id: Q38CQ0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb09.160.5480
gene id: 185431:Tb09.160.5480
uniprot id: Q38EK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

185431:Tb10.70.6880
gene id: 185431:Tb10.70.6880
uniprot id: Q38CB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.
messages: cytoskeleton

185431:Tb927.3.1370
gene id: 185431:Tb927.3.1370
uniprot id: Q57XX0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

185431:Tb927.5.3070
gene id: 185431:Tb927.5.3070
uniprot id: Q57Z86
names: Subcellular Location Annotation
messages: Cytoplasm

185431:TB927.1.4500
gene id: 185431:TB927.1.4500
uniprot id: Q4GYC8
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.70.1300
gene id: 185431:Tb10.70.1300
uniprot id: Q38B35
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

185431:Tb927.4.3790
gene id: 185431:Tb927.4.3790
uniprot id: Q583H3
names: Similarity
messages: Belongs to the peptidase C19 family.

185431:Tb10.70.5220
gene id: 185431:Tb10.70.5220
uniprot id: Q38BZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

185431:Tb09.160.4250
gene id: 185431:Tb09.160.4250
uniprot id: Q38EX8
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

185431:Tb10.406.0210
gene id: 185431:Tb10.406.0210
uniprot id: Q389Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body

185431:Tb927.8.7730
gene id: 185431:Tb927.8.7730
uniprot id: Q57V92
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.8.2930
gene id: 185431:Tb927.8.2930
uniprot id: Q57W80
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

185431:Tb10.6k15.2790
gene id: 185431:Tb10.6k15.2790
uniprot id: Q38AI6
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

185431:Tb927.5.5050
gene id: 185431:Tb927.5.5050
uniprot id: Q57XG5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.6k15.1330
gene id: 185431:Tb10.6k15.1330
uniprot id: Q38A65
names: Function
messages: Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

185431:Tb927.3.2980
gene id: 185431:Tb927.3.2980
uniprot id: Q57ZL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

185431:TB927.1.2880
gene id: 185431:TB927.1.2880
uniprot id: Q4GYT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.
messages: Membrane

185431:Tb927.5.1260
gene id: 185431:Tb927.5.1260
uniprot id: Q57VD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

185431:Tb10.61.1750
gene id: 185431:Tb10.61.1750
uniprot id: Q388B7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.5.960
gene id: 185431:Tb927.5.960
uniprot id: Q57W41
names: Similarity
messages: Belongs to the AAA ATPase family.

185431:Tb09.160.3960
gene id: 185431:Tb09.160.3960
uniprot id: Q38F11
names: Similarity
messages: Belongs to the actin family.

185431:Tb10.61.0980
gene id: 185431:Tb10.61.0980
uniprot id: Q387X2
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

185431:Tb927.6.960
gene id: 185431:Tb927.6.960
uniprot id: Q585F0
names: Similarity
messages: Belongs to the peptidase C1 family.

185431:Tb927.8.5990
gene id: 185431:Tb927.8.5990
uniprot id: Q57YK0
names: Subcellular Location Annotation
messages: nucleolus

185431:Tb927.6.1460
gene id: 185431:Tb927.6.1460
uniprot id: Q585A1
names: Similarity
messages: Belongs to the cyclin family.

185431:Tb927.7.5830
gene id: 185431:Tb927.7.5830
uniprot id: Q582J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

185431:Tb927.7.1300
gene id: 185431:Tb927.7.1300
uniprot id: Q57WS0
names: Similarity
messages: Belongs to the protein disulfide isomerase family.

185431:Tb927.8.1630
gene id: 185431:Tb927.8.1630
uniprot id: Q580G0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

185431:Tb10.70.0830
gene id: 185431:Tb10.70.0830
uniprot id: Q38B01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

185431:Tb927.6.5020
gene id: 185431:Tb927.6.5020
uniprot id: Q586H4
names: Similarity
messages: Belongs to the cyclin family.

185431:Tb927.7.2890
gene id: 185431:Tb927.7.2890
uniprot id: Q57YA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.2.3910
gene id: 185431:Tb927.2.3910
uniprot id: Q586W9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

185431:Tb927.8.3150
gene id: 185431:Tb927.8.3150
uniprot id: Q57YZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.

185431:Tb10.70.5120
gene id: 185431:Tb10.70.5120
uniprot id: Q38BZ0
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

185431:Tb10.61.0280
gene id: 185431:Tb10.61.0280
uniprot id: Q387R5
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.6.4890
gene id: 185431:Tb927.6.4890
uniprot id: Q586G1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

185431:Tb10.61.0150
gene id: 185431:Tb10.61.0150
uniprot id: Q387Q3
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

185431:Tb09.160.5350
gene id: 185431:Tb09.160.5350
uniprot id: Q38EL6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.8.6000
gene id: 185431:Tb927.8.6000
uniprot id: Q57YK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane

185431:Tb927.2.5800
gene id: 185431:Tb927.2.5800
uniprot id: Q586C9
names: Similarity
messages: Belongs to the FBPase class 1 family.

185431:Tb927.7.3430
gene id: 185431:Tb927.7.3430
uniprot id: Q57WF8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

185431:Tb927.2.1760
gene id: 185431:Tb927.2.1760
uniprot id: Q585S4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb927.4.2740
gene id: 185431:Tb927.4.2740
uniprot id: D6XFL0
names: Similarity
messages: Belongs to the TPPP family.

185431:Tb927.6.1860
gene id: 185431:Tb927.6.1860
uniprot id: Q585M5
names: Similarity
messages: Belongs to the RRF family.

185431:Tb10.6k15.1220
gene id: 185431:Tb10.6k15.1220
uniprot id: Q38A55
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

185431:Tb09.211.4480
gene id: 185431:Tb09.211.4480
uniprot id: Q38D64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

185431:Tb09.160.3690
gene id: 185431:Tb09.160.3690
uniprot id: Q38F36
names: Similarity
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

185431:Tb927.4.2880
gene id: 185431:Tb927.4.2880
uniprot id: Q583W5
names: Similarity
messages: Belongs to the NUP186/NUP192/NUP205 family.

185431:Tb10.70.0790
gene id: 185431:Tb10.70.0790
uniprot id: Q38AZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

185431:TB927.1.2360
gene id: 185431:TB927.1.2360
uniprot id: Q4GYY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

185431:Tb927.8.4580
gene id: 185431:Tb927.8.4580
uniprot id: Q57UZ3
names: Similarity
messages: Belongs to the CFAP45 family.

185431:Tb927.7.100
gene id: 185431:Tb927.7.100
uniprot id: Q57U38
names: Function
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb09.160.0500
gene id: 185431:Tb09.160.0500
uniprot id: Q38FZ0
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.4.1900
gene id: 185431:Tb927.4.1900
uniprot id: Q583K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

185431:Tb927.8.1360
gene id: 185431:Tb927.8.1360
uniprot id: Q57VL9
names: Similarity
messages: Belongs to the dynein heavy chain family.

185431:Tb927.7.4650
gene id: 185431:Tb927.7.4650
uniprot id: D6XIZ6
uniprot id: Q57X81
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Probably also acts as a DNA helicase. Recognizes and binds specific regions of the genome, hydrolyzes ATP and allows the DNA base J de novo synthesis. Involved in initial synthesis of DNA base J, JBP1 being able to act via the basal level of DNA base J and propagate further synthesis. In contrast to JBP1, it does not specifically bind DNA base J, however it binds chromatin.
messages: Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Probably also acts as a DNA helicase. Recognizes and binds specific regions of the genome, hydrolyzes ATP and allows the DNA base J de novo synthesis. Involved in initial synthesis of DNA base J, JBP1 being able to act via the basal level of DNA base J and propagate further synthesis. In contrast to JBP1, it does not specifically bind DNA base J, it however binds chromatin.
messages: Expressed in bloodstream form.
messages: In the C-terminal section; belongs to the SNF2/RAD54 helicase family.
messages: In the N-terminal section; belongs to the TET family. JBP2 subfamily.
messages: Nucleus
messages: The genome contains reduced level of DNA base J in the DNA. Cells lacking both JBP1 and JBP2 show a complete absence of base J.

185431:Tb927.6.850
gene id: 185431:Tb927.6.850
uniprot id: Q585G1
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

185431:Tb927.6.3840
gene id: 185431:Tb927.6.3840
uniprot id: Q585Y2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

185431:Tb927.8.6950
gene id: 185431:Tb927.8.6950
uniprot id: Q57YQ2
names: Similarity
messages: Belongs to the GAMAD family.

185431:Tb09.211.3210
gene id: 185431:Tb09.211.3210
uniprot id: Q38DI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum

185431:Tb927.7.1620
gene id: 185431:Tb927.7.1620
uniprot id: Q57WN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

185431:Tb927.3.3450
gene id: 185431:Tb927.3.3450
uniprot id: Q57XJ5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

185431:Tb927.8.7390
gene id: 185431:Tb927.8.7390
uniprot id: Q57YU1
names: Similarity
messages: Belongs to the PPP phosphatase family.

185431:Tb927.7.3860
gene id: 185431:Tb927.7.3860
uniprot id: Q57UD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane

185431:Tb10.6k15.0960
gene id: 185431:Tb10.6k15.0960
uniprot id: Q38A31
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

185431:Tb10.70.1660
gene id: 185431:Tb10.70.1660
uniprot id: Q38B65
names: Subcellular Location Annotation
messages: cilium

185431:Tb927.3.5640
gene id: 185431:Tb927.3.5640
uniprot id: Q57VH9
names: Similarity
messages: Belongs to the NFX1 family.

185431:Tb927.2.5030
gene id: 185431:Tb927.2.5030
uniprot id: Q586U1
names: Similarity
messages: Belongs to the SPT5 family.

185431:Tb10.6k15.2520
gene id: 185431:Tb10.6k15.2520
uniprot id: Q38AG2
names: Similarity
messages: Belongs to the peptidase S9A family.

185431:Tb927.7.4970
gene id: 185431:Tb927.7.4970
uniprot id: Q57ZJ2
names: Similarity
messages: Belongs to the glutamine synthetase family.

185431:Tb10.70.1690
gene id: 185431:Tb10.70.1690
uniprot id: Q38B67
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

185431:Tb927.5.5210
gene id: 185431:Tb927.5.5210
uniprot id: Q57UD7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb09.211.0440
gene id: 185431:Tb09.211.0440
uniprot id: Q38EB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
messages: nucleolus

185431:Tb927.6.5120
gene id: 185431:Tb927.6.5120
uniprot id: Q586I4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: P1 and P2 exist as dimers at the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

185431:Tb09.211.0680
gene id: 185431:Tb09.211.0680
uniprot id: Q38E89
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

185431:Tb927.8.7790
gene id: 185431:Tb927.8.7790
uniprot id: Q57U64
names: Subcellular Location Annotation
messages: Nucleus

185431:Tb09.211.2960
gene id: 185431:Tb09.211.2960
uniprot id: Q38DL0
names: Similarity
messages: Belongs to the PNO1 family.

185431:Tb09.160.3630
gene id: 185431:Tb09.160.3630
uniprot id: Q38F42
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

185431:Tb927.7.4820
gene id: 185431:Tb927.7.4820
uniprot id: Q57X98
names: Similarity
messages: Belongs to the TRM112 family.

185431:Tb10.406.0350
gene id: 185431:Tb10.406.0350
uniprot id: Q389T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb10.70.6040
gene id: 185431:Tb10.70.6040
uniprot id: Q38C62
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

185431:Tb927.8.3650
gene id: 185431:Tb927.8.3650
uniprot id: Q580Y5
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.389.0430
gene id: 185431:Tb10.389.0430
uniprot id: Q388U2
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.2.2240
gene id: 185431:Tb927.2.2240
uniprot id: Q586K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

185431:Tb09.211.2560
gene id: 185431:Tb09.211.2560
uniprot id: Q38DQ0
names: Subcellular Location Annotation
messages: cilium axoneme

185431:Tb10.26.0750
gene id: 185431:Tb10.26.0750
uniprot id: Q389L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS41 family.
messages: Mitochondrion

185431:Tb927.7.6930
gene id: 185431:Tb927.7.6930
uniprot id: Q57XR3
names: Similarity
messages: Belongs to the AFG1 ATPase family.

185431:Tb927.3.2420
gene id: 185431:Tb927.3.2420
uniprot id: Q582V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

185431:Tb927.5.2720
gene id: 185431:Tb927.5.2720
uniprot id: Q57ZU8
names: Similarity
messages: Belongs to the ZPR1 family.

185431:Tb927.6.4210
gene id: 185431:Tb927.6.4210
uniprot id: Q586Y8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

185431:Tb10.70.2155
gene id: 185431:Tb10.70.2155
uniprot id: Q38B96
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.

185431:Tb927.4.750
gene id: 185431:Tb927.4.750
uniprot id: Q580A3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.

185431:Tb927.2.6180
gene id: 185431:Tb927.2.6180
uniprot id: Q586N4
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

185431:Tb927.5.2420
gene id: 185431:Tb927.5.2420
uniprot id: Q582C3
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb09.211.4290
gene id: 185431:Tb09.211.4290
uniprot id: Q38D81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Nucleus

185431:Tb09.211.0340
gene id: 185431:Tb09.211.0340
uniprot id: Q38EC5
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

185431:Tb927.4.5290
gene id: 185431:Tb927.4.5290
uniprot id: Q584H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb927.3.1530
gene id: 185431:Tb927.3.1530
uniprot id: Q57XY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

185431:Tb927.8.1530
gene id: 185431:Tb927.8.1530
uniprot id: Q580H0
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.3.1000
gene id: 185431:Tb927.3.1000
uniprot id: Q57WY3
names: Similarity
messages: Belongs to the frataxin family.

185431:Tb10.406.0500
gene id: 185431:Tb10.406.0500
uniprot id: Q389T6
names: Similarity
messages: Belongs to the MCM family.

185431:Tb10.100.0070
gene id: 185431:Tb10.100.0070
uniprot id: Q38CM0
names: Similarity
messages: Belongs to the ATPase gamma chain family.

185431:Tb927.6.4410
gene id: 185431:Tb927.6.4410
uniprot id: Q587A7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.

185431:Tb927.5.300
gene id: 185431:Tb927.5.300
uniprot id: Q57XH4
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

185431:Tb927.6.2960
gene id: 185431:Tb927.6.2960
uniprot id: Q583N8
names: Function
names: Similarity
names: Subunit
messages: AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.
messages: Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins, a medium adaptin and a small adaptin.
messages: Belongs to the adaptor complexes large subunit family.

185431:Tb09.211.4512
gene id: 185431:Tb09.211.4512
uniprot id: Q38D58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KMP-11 family.
messages: Monomer.
messages: cytoskeleton

185431:Tb10.6k15.1130
gene id: 185431:Tb10.6k15.1130
uniprot id: Q38A47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

185431:Tb927.7.2670
gene id: 185431:Tb927.7.2670
uniprot id: Q57Y77
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
messages: Expressed in the procyclic form.
messages: Induced during the differentiation of the bloodstream form to the procyclic form.
messages: RNA-binding protein involved in regulation of mRNA stability (PubMed:31743541). Promotes mRNA stabilization by recruiting MKT1 and PBP1 (By similarity). Stabilizes transcripts encoding mitochondrial proteins (PubMed:31743541).
messages: RNAi-mediated knockdown in procyclic form does not affect growth rate (PubMed:31743541). Simultaneous knockdown of ZC3H20 and ZC3H21 in the procyclic form results in a severe population growth defect and a shift towards the bloodstream form transcriptome (PubMed:31743541). Simultaneous knockdown of ZC3H20 and ZC3H21 in the bloodstream form is lethal (PubMed:31743541).

185431:Tb927.7.1750
gene id: 185431:Tb927.7.1750
uniprot id: Q57V35
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

185431:Tb09.211.3955
gene id: 185431:Tb09.211.3955
uniprot id: Q38DB3
names: Similarity
messages: Belongs to the HSBP1 family.

185431:Tb927.4.3840
gene id: 185431:Tb927.4.3840
uniprot id: Q583H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

185431:Tb09.211.0630
gene id: 185431:Tb09.211.0630
uniprot id: Q38E94
names: Similarity
messages: Belongs to the actin family.

185431:Tb10.70.5570
gene id: 185431:Tb10.70.5570
uniprot id: Q38C26
names: Similarity
messages: Belongs to the RPAP2 family.

185431:Tb927.5.3750
gene id: 185431:Tb927.5.3750
uniprot id: Q57U91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

185431:Tb09.160.0450
gene id: 185431:Tb09.160.0450
uniprot id: Q38FZ6
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb10.389.0280
gene id: 185431:Tb10.389.0280
uniprot id: Q388S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: nucleolus

185431:Tb927.3.3900
gene id: 185431:Tb927.3.3900
uniprot id: Q57WC6
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

185431:Tb927.7.2850
gene id: 185431:Tb927.7.2850
uniprot id: Q57YA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb10.70.6540
gene id: 185431:Tb10.70.6540
uniprot id: Q38C93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

185431:Tb10.61.0210
gene id: 185431:Tb10.61.0210
uniprot id: Q387Q8
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

185431:Tb927.5.2430
gene id: 185431:Tb927.5.2430
uniprot id: Q582C2
names: Similarity
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.

185431:Tb09.142.0100
gene id: 185431:Tb09.142.0100
uniprot id: Q38G44
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

185431:Tb10.389.0150
gene id: 185431:Tb10.389.0150
uniprot id: Q388R9
names: Similarity
messages: Belongs to the GCN1 family.

185431:Tb927.8.2600
gene id: 185431:Tb927.8.2600
uniprot id: Q57XC9
names: Subcellular Location Annotation
messages: nucleolus

185431:Tb10.70.6330
gene id: 185431:Tb10.70.6330
uniprot id: Q38C83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Membrane
messages: Mitochondrion inner membrane

185431:Tb927.4.4030
gene id: 185431:Tb927.4.4030
uniprot id: Q57Y07
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

185431:Tb09.160.1220
gene id: 185431:Tb09.160.1220
uniprot id: Q38FR4
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.5.4560
gene id: 185431:Tb927.5.4560
uniprot id: Q57X48
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

185431:Tb927.5.4240
gene id: 185431:Tb927.5.4240
uniprot id: Q57Z31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the histone H4 family.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.7.2880
gene id: 185431:Tb927.7.2880
uniprot id: Q57YA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.8.2090
gene id: 185431:Tb927.8.2090
uniprot id: Q581X3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

185431:Tb927.4.3380
gene id: 185431:Tb927.4.3380
uniprot id: Q585L2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

185431:Tb10.389.0690
gene id: 185431:Tb10.389.0690
uniprot id: Q388W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

185431:Tb927.8.2530
gene id: 185431:Tb927.8.2530
uniprot id: Q57XD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

185431:Tb10.406.0540
gene id: 185431:Tb10.406.0540
uniprot id: Q389T9
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.

185431:Tb927.3.4020
gene id: 185431:Tb927.3.4020
uniprot id: Q57WD8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

185431:Tb10.61.2550
gene id: 185431:Tb10.61.2550
uniprot id: Q388H8
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

185431:Tb927.7.4180
gene id: 185431:Tb927.7.4180
uniprot id: Q57UP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

185431:Tb10.6k15.0990
gene id: 185431:Tb10.6k15.0990
uniprot id: Q38A34
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: RNAi-mediated knock down in procyclic and blood stream forms (strain 29-13) impairs growth following prolonged exposure to oxidative stress.
messages: Synthesizes selenophosphate from selenide and ATP.

185431:Tb927.7.3530
gene id: 185431:Tb927.7.3530
uniprot id: Q57WG8
names: Similarity
messages: Belongs to the VAC14 family.

185431:Tb927.7.4110
gene id: 185431:Tb927.7.4110
uniprot id: Q57UP1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb10.70.4620
gene id: 185431:Tb10.70.4620
uniprot id: Q38BV1
names: Similarity
messages: Belongs to the SNAP family.

185431:Tb09.244.2240
gene id: 185431:Tb09.244.2240
uniprot id: Q38CT8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.8.7020
gene id: 185431:Tb927.8.7020
uniprot id: Q57YQ9
names: Similarity
messages: Belongs to the peptidase M16 family.

185431:Tb927.7.7450
gene id: 185431:Tb927.7.7450
uniprot id: Q57TY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

185431:Tb927.8.5030
gene id: 185431:Tb927.8.5030
uniprot id: Q57UH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

185431:Tb927.7.5970
gene id: 185431:Tb927.7.5970
uniprot id: Q57VL2
names: Subcellular Location Annotation
messages: Membrane

185431:Tb09.211.4190
gene id: 185431:Tb09.211.4190
uniprot id: Q38D90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP53 family.
messages: nucleolus
messages: nucleoplasm

185431:Tb927.8.6110
gene id: 185431:Tb927.8.6110
uniprot id: Q57YL2
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

185431:Tb09.160.1440
gene id: 185431:Tb09.160.1440
uniprot id: Q38FP4
names: Similarity
messages: Belongs to the MAPRE family.

185431:Tb927.4.3300
gene id: 185431:Tb927.4.3300
uniprot id: Q584A7
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

185431:Tb927.3.4160
gene id: 185431:Tb927.3.4160
uniprot id: Q580M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

185431:Tb927.6.4300
gene id: 185431:Tb927.6.4300
uniprot id: Q586Z6
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

185431:Tb10.70.7100
gene id: 185431:Tb10.70.7100
uniprot id: Q38CD7
names: Similarity
messages: Belongs to the peptidase S10 family.

185431:TB927.1.5330
gene id: 185431:TB927.1.5330
uniprot id: Q4GY50
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.70.1800
gene id: 185431:Tb10.70.1800
uniprot id: Q38B76
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.6.3740
gene id: 185431:Tb927.6.3740
uniprot id: Q585X3
names: Similarity
messages: Belongs to the heat shock protein 70 family.

185431:Tb10.6k15.2030
gene id: 185431:Tb10.6k15.2030
uniprot id: Q38AB9
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

185431:Tb927.8.2940
gene id: 185431:Tb927.8.2940
uniprot id: Q57W79
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

185431:TB927.1.3180
gene id: 185431:TB927.1.3180
uniprot id: Q4GYQ5
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

185431:Tb927.3.370
gene id: 185431:Tb927.3.370
uniprot id: Q57TR5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.6k15.0290
gene id: 185431:Tb10.6k15.0290
uniprot id: Q389X7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

185431:Tb927.8.7410
gene id: 185431:Tb927.8.7410
uniprot id: Q57YU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

185431:Tb09.160.0580
gene id: 185431:Tb09.160.0580
uniprot id: Q38FY1
names: Similarity
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.

185431:Tb10.6k15.2720
gene id: 185431:Tb10.6k15.2720
uniprot id: Q38AH9
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

185431:Tb927.6.280
gene id: 185431:Tb927.6.280
uniprot id: Q581E1
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb09.211.4470
gene id: 185431:Tb09.211.4470
uniprot id: Q38D64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

185431:Tb927.4.2110
gene id: 185431:Tb927.4.2110
uniprot id: Q583I2
names: Similarity
messages: Belongs to the PP2C family.

185431:Tb927.8.5120
gene id: 185431:Tb927.8.5120
uniprot id: Q57UI4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space

185431:Tb927.4.2860
gene id: 185431:Tb927.4.2860
uniprot id: Q583W3
names: Similarity
messages: Belongs to the SNF8 family.

185431:Tb927.6.470
gene id: 185431:Tb927.6.470
uniprot id: Q581F5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.7.3650
gene id: 185431:Tb927.7.3650
uniprot id: Q57WI0
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.8.2020
gene id: 185431:Tb927.8.2020
uniprot id: Q581Y0
names: Similarity
messages: Belongs to the arginase family.

185431:Tb927.4.1270
gene id: 185431:Tb927.4.1270
uniprot id: Q581V4
names: Similarity
messages: Belongs to the RuvB family.

185431:Tb927.3.1070
gene id: 185431:Tb927.3.1070
uniprot id: Q57WY8
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

185431:Tb10.6k15.1570
gene id: 185431:Tb10.6k15.1570
uniprot id: Q38A84
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

185431:Tb10.6k15.2900
gene id: 185431:Tb10.6k15.2900
uniprot id: Q38AJ4
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.61.2650
gene id: 185431:Tb10.61.2650
uniprot id: Q388I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

185431:Tb927.5.1100
gene id: 185431:Tb927.5.1100
uniprot id: Q57W55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Cytoplasm
messages: Membrane

185431:Tb10.6k15.3250
gene id: 185431:Tb10.6k15.3250
uniprot id: Q38AM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

185431:Tb927.2.4620
gene id: 185431:Tb927.2.4620
uniprot id: Q586R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

185431:Tb927.4.1400
gene id: 185431:Tb927.4.1400
uniprot id: Q581U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Late endosome membrane

185431:Tb927.6.1270
gene id: 185431:Tb927.6.1270
uniprot id: Q585C0
names: Similarity
messages: Belongs to the PITHD1 family.

185431:Tb10.6k15.0510
gene id: 185431:Tb10.6k15.0510
uniprot id: Q389Z6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

185431:Tb09.160.2490
gene id: 185431:Tb09.160.2490
uniprot id: Q38FE4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.

185431:Tb10.6k15.4010
gene id: 185431:Tb10.6k15.4010
uniprot id: Q38AT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

185431:Tb09.244.1830
gene id: 185431:Tb09.244.1830
uniprot id: Q38CQ9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb09.211.2780
gene id: 185431:Tb09.211.2780
uniprot id: Q38DM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

185431:TB927.1.2350
gene id: 185431:TB927.1.2350
uniprot id: Q4GYY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

185431:Tb10.406.0600
gene id: 185431:Tb10.406.0600
uniprot id: Q389U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Nucleus

185431:Tb10.70.5800
gene id: 185431:Tb10.70.5800
uniprot id: Q38C41
names: Similarity
messages: Belongs to the hexokinase family.

185431:Tb927.8.3180
gene id: 185431:Tb927.8.3180
uniprot id: Q57YZ5
names: Similarity
messages: Belongs to the RPGRIP1 family.

185431:Tb927.4.2380
gene id: 185431:Tb927.4.2380
uniprot id: Q584E9
names: Subcellular Location Annotation
messages: Cell membrane

185431:Tb09.211.0790
gene id: 185431:Tb09.211.0790
uniprot id: Q38E77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Nucleus

185431:Tb10.406.0370
gene id: 185431:Tb10.406.0370
uniprot id: Q389T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.4.1510
gene id: 185431:Tb927.4.1510
uniprot id: Q581T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

185431:Tb10.61.2090
gene id: 185431:Tb10.61.2090
uniprot id: Q385T6
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

185431:Tb10.61.0990
gene id: 185431:Tb10.61.0990
uniprot id: Q387X3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb10.6k15.2460
gene id: 185431:Tb10.6k15.2460
uniprot id: Q38AF7
names: Similarity
messages: Belongs to the AFG1 ATPase family.

185431:Tb10.6k15.3500
gene id: 185431:Tb10.6k15.3500
uniprot id: Q38AP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

185431:Tb10.61.1990
gene id: 185431:Tb10.61.1990
uniprot id: Q388D6
names: Similarity
messages: Belongs to the BRX1 family.

185431:TB927.1.2490
gene id: 185431:TB927.1.2490
uniprot id: Q4GYX7
names: Similarity
messages: Belongs to the histone H3 family.

185431:Tb10.26.0780
gene id: 185431:Tb10.26.0780
uniprot id: Q389L6
names: Similarity
messages: Belongs to the NKAP family.

185431:Tb927.6.450
gene id: 185431:Tb927.6.450
uniprot id: Q581F3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Major surface antigen of procyclic forms.
messages: Membrane

185431:Tb10.70.2490
gene id: 185431:Tb10.70.2490
uniprot id: Q38BD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

185431:Tb10.6k15.0530
gene id: 185431:Tb10.6k15.0530
uniprot id: Q389Z8
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.

185431:Tb09.244.1840
gene id: 185431:Tb09.244.1840
uniprot id: Q38CR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb10.6k15.1350
gene id: 185431:Tb10.6k15.1350
uniprot id: Q38A66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.
messages: Membrane

185431:Tb927.4.320
gene id: 185431:Tb927.4.320
uniprot id: Q57UU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

185431:Tb10.70.3170
gene id: 185431:Tb10.70.3170
uniprot id: Q38BI9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

185431:Tb927.8.2240
gene id: 185431:Tb927.8.2240
uniprot id: Q581V8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

185431:Tb927.6.3000
gene id: 185431:Tb927.6.3000
uniprot id: Q583N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Membrane

185431:Tb927.8.3060
gene id: 185431:Tb927.8.3060
uniprot id: Q57W67
names: Similarity
messages: Belongs to the peptidase M17 family.

185431:Tb10.389.0350
gene id: 185431:Tb10.389.0350
uniprot id: Q388T6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: cytoskeleton

185431:Tb10.61.1810
gene id: 185431:Tb10.61.1810
uniprot id: Q388C4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

185431:Tb927.4.3640
gene id: 185431:Tb927.4.3640
uniprot id: Q585I6
names: Similarity
messages: Belongs to the PPP phosphatase family.

185431:Tb10.6k15.3230
gene id: 185431:Tb10.6k15.3230
uniprot id: Q38AM0
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

185431:Tb927.5.2090
gene id: 185431:Tb927.5.2090
uniprot id: Q57ZS8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.7.4560
gene id: 185431:Tb927.7.4560
uniprot id: D6XIY7
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

185431:Tb09.211.0910
gene id: 185431:Tb09.211.0910
uniprot id: Q38E65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

185431:Tb10.70.7520
gene id: 185431:Tb10.70.7520
uniprot id: Q38CH1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

185431:Tb09.v1.0640
gene id: 185431:Tb09.v1.0640
uniprot id: Q38DN9
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

185431:Tb927.6.2280
gene id: 185431:Tb927.6.2280
uniprot id: Q584S2
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

185431:Tb09.160.2600
gene id: 185431:Tb09.160.2600
uniprot id: Q38FD5
names: Similarity
messages: Belongs to the isochorismatase family.

185431:Tb927.2.4740
gene id: 185431:Tb927.2.4740
uniprot id: Q586R9
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

185431:Tb927.3.4840
gene id: 185431:Tb927.3.4840
uniprot id: Q582Q1
names: Similarity
messages: Belongs to the peptidase C19 family.

185431:Tb09.211.4610
gene id: 185431:Tb09.211.4610
uniprot id: Q38D47
names: Similarity
messages: Belongs to the synaptobrevin family.

185431:Tb09.160.4300
gene id: 185431:Tb09.160.4300
uniprot id: Q38EX7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

185431:Tb927.6.3300
gene id: 185431:Tb927.6.3300
uniprot id: D6XI63
uniprot id: Q9BPQ5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: In T.brucei, PIGM has a different substrate specificity compared to mammalian. Given that the protozoan parasite evades the immune response of mammalian hosts and digestion in the gut of the insect vector by means of its coat proteins tethered to the cell surface via GPI-anchors, it may be a good candidate for chemotherapy against African trypanosomiasis.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-PI during GPI precursor assembly (By similarity).
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

185431:Tb10.100.0155
gene id: 185431:Tb10.100.0155
uniprot id: Q38CL1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

185431:TB927.1.3830
gene id: 185431:TB927.1.3830
uniprot id: Q4GYJ4
names: Similarity
messages: Belongs to the GPI family.

185431:Tb09.244.2590
gene id: 185431:Tb09.244.2590
uniprot id: Q38CW9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

185431:Tb927.6.790
gene id: 185431:Tb927.6.790
uniprot id: Q583S4
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.8.4880
gene id: 185431:Tb927.8.4880
uniprot id: Q57UW4
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

185431:Tb927.2.1700
gene id: 185431:Tb927.2.1700
uniprot id: Q585S0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb10.61.2970
gene id: 185431:Tb10.61.2970
uniprot id: Q388K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

185431:Tb927.3.490
gene id: 185431:Tb927.3.490
uniprot id: Q57TR3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.7.6260
gene id: 185431:Tb927.7.6260
uniprot id: Q57VI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

185431:Tb927.6.2140
gene id: 185431:Tb927.6.2140
uniprot id: Q584U2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the REH2-associated complex (REH2C) composed of helicase REH2, associated factors H2F1 and H2F2, and mRNAs at various editing stages; the formation of the complex is RNA-independent (PubMed:26769962). Interacts with various editing complexes including the RNA editing core (RECC) complex, the gRNA-binding (GRBC) complex (also known as the MRB1 complex) and the RNA editing mediator (REMC) complex (PubMed:26769962).
messages: Expressed at the procyclic stage (at protein level).
messages: May play a role in mitochondrial mRNA editing by facilitating the association of the gRNA-binding (GRBC) complex with the RNA editing core (RECC) complex (PubMed:26769962). However, appears to be dispensable for mRNA editing per se (PubMed:26769962).
messages: Mitochondrion
messages: RNAi-mediated knockdown at the procyclic stage does not cause defects in RHE2 interaction with H2F1 or their association with components of the RECC and GRBC editing complexes; however, causes a slight decrease in the association of the GRBC complex with the RECC complex (PubMed:26769962). No defect in mitochondrial mRNA editing (PubMed:26769962).

185431:Tb10.61.1790
gene id: 185431:Tb10.61.1790
uniprot id: Q388C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I LYR family.
messages: Mitochondrion inner membrane

185431:Tb927.2.6200
gene id: 185431:Tb927.2.6200
uniprot id: Q586N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

185431:Tb10.6k15.1410
gene id: 185431:Tb10.6k15.1410
uniprot id: Q38A72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

185431:Tb927.5.3990
gene id: 185431:Tb927.5.3990
uniprot id: Q57Z50
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

185431:Tb927.5.2320
gene id: 185431:Tb927.5.2320
uniprot id: Q582D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAK10 family.
messages: Cytoplasm

185431:Tb927.7.7120
gene id: 185431:Tb927.7.7120
uniprot id: Q57XT2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb10.389.1290
gene id: 185431:Tb10.389.1290
uniprot id: Q389A0
names: Similarity
messages: Belongs to the NOC2 family.

185431:Tb927.6.300
gene id: 185431:Tb927.6.300
uniprot id: Q581E2
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.7.2910
gene id: 185431:Tb927.7.2910
uniprot id: Q57YA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb09.160.3270
gene id: 185431:Tb09.160.3270
uniprot id: Q38F76
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G (By similarity).

185431:Tb927.2.2920
gene id: 185431:Tb927.2.2920
uniprot id: Q587G8
names: Subcellular Location Annotation
messages: Membrane

185431:Tb09.244.0910
gene id: 185431:Tb09.244.0910
uniprot id: Q38CP5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.406.0380
gene id: 185431:Tb10.406.0380
uniprot id: Q389T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.4.5030
gene id: 185431:Tb927.4.5030
uniprot id: Q584K2
names: Similarity
messages: Belongs to the PPP phosphatase family.

185431:Tb10.70.4070
gene id: 185431:Tb10.70.4070
uniprot id: Q38BQ9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

185431:Tb09.160.2450
gene id: 185431:Tb09.160.2450
uniprot id: Q38FE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

185431:Tb927.8.1640
gene id: 185431:Tb927.8.1640
uniprot id: Q580F9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

185431:Tb10.70.2450
gene id: 185431:Tb10.70.2450
uniprot id: Q38BC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC3 family.
messages: Membrane

185431:Tb927.6.4860
gene id: 185431:Tb927.6.4860
uniprot id: Q586G3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

185431:Tb10.61.2750
gene id: 185431:Tb10.61.2750
uniprot id: Q388P0
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.4.4430
gene id: 185431:Tb927.4.4430
uniprot id: Q583C8
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb10.389.1870
gene id: 185431:Tb10.389.1870
uniprot id: Q389F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

185431:Tb927.8.5890
gene id: 185431:Tb927.8.5890
uniprot id: Q57YJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

185431:Tb10.6k15.3110
gene id: 185431:Tb10.6k15.3110
uniprot id: Q38AL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAN1 family.
messages: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
messages: Nucleus

185431:Tb927.8.2540
gene id: 185431:Tb927.8.2540
uniprot id: Q57XD5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

185431:Tb927.7.7140
gene id: 185431:Tb927.7.7140
uniprot id: Q57XT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

185431:Tb10.389.0910
gene id: 185431:Tb10.389.0910
uniprot id: Q388X5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

185431:Tb10.6k15.1520
gene id: 185431:Tb10.6k15.1520
uniprot id: Q38A82
names: Similarity
messages: Belongs to the GTR/RAG GTP-binding protein family.

185431:Tb927.6.4910
gene id: 185431:Tb927.6.4910
uniprot id: Q586G3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

185431:Tb927.8.980
gene id: 185431:Tb927.8.980
uniprot id: Q57XH7
names: Cofactor
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.

185431:Tb10.70.7030
gene id: 185431:Tb10.70.7030
uniprot id: Q38CD1
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

185431:Tb927.8.1930
gene id: 185431:Tb927.8.1930
uniprot id: Q581Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

185431:TB927.1.2400
gene id: 185431:TB927.1.2400
uniprot id: Q4GYY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

185431:Tb927.3.5500
gene id: 185431:Tb927.3.5500
uniprot id: Q580S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

185431:Tb927.7.2540
gene id: 185431:Tb927.7.2540
uniprot id: Q57XM0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

185431:Tb927.6.430
gene id: 185431:Tb927.6.430
uniprot id: Q581F1
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.3.3850
gene id: 185431:Tb927.3.3850
uniprot id: Q57WC1
names: Similarity
messages: Belongs to the SEC16 family.

185431:Tb927.5.1530
gene id: 185431:Tb927.5.1530
uniprot id: Q57VB0
names: Similarity
messages: Belongs to the FMO family.

185431:Tb09.211.1820
gene id: 185431:Tb09.211.1820
uniprot id: Q38DX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: DNA polymerase II participates in chromosomal DNA replication.
messages: Nucleus

185431:Tb927.5.5240
gene id: 185431:Tb927.5.5240
uniprot id: Q57UD6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.5.4550
gene id: 185431:Tb927.5.4550
uniprot id: Q57X49
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.7.1770
gene id: 185431:Tb927.7.1770
uniprot id: Q57V33
names: Subcellular Location Annotation
messages: Nucleus

185431:Tb927.7.5450
gene id: 185431:Tb927.7.5450
uniprot id: Q582G0
names: Similarity
messages: Belongs to the lipin family.

185431:Tb927.7.3000
gene id: 185431:Tb927.7.3000
uniprot id: Q57YB0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:TB927.1.2820
gene id: 185431:TB927.1.2820
uniprot id: Q4GYU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.
messages: Membrane

185431:Tb10.70.4740
gene id: 185431:Tb10.70.4740
uniprot id: Q38BV6
names: Similarity
messages: Belongs to the enolase family.

185431:Tb927.4.5460
gene id: 185431:Tb927.4.5460
uniprot id: Q580P2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.6k15.3340
gene id: 185431:Tb10.6k15.3340
uniprot id: Q38AM9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

185431:Tb927.6.1900
gene id: 185431:Tb927.6.1900
uniprot id: Q585M1
names: Similarity
messages: Belongs to the bystin family.

185431:Tb09.211.1750
gene id: 185431:Tb09.211.1750
uniprot id: Q38DX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

185431:Tb927.3.1280
gene id: 185431:Tb927.3.1280
uniprot id: Q57XW1
names: Similarity
messages: Belongs to the NPL4 family.

185431:Tb10.61.0880
gene id: 185431:Tb10.61.0880
uniprot id: Q387W4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

185431:Tb927.6.1040
gene id: 185431:Tb927.6.1040
uniprot id: Q585E3
names: Similarity
messages: Belongs to the peptidase C1 family.

185431:Tb927.3.4960
gene id: 185431:Tb927.3.4960
uniprot id: Q582P0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.6.2060
gene id: 185431:Tb927.6.2060
uniprot id: Q584V0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

185431:Tb10.v4.0031
gene id: 185431:Tb10.v4.0031
uniprot id: Q387P0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.3.5580
gene id: 185431:Tb927.3.5580
uniprot id: Q580R7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

185431:Tb10.61.0380
gene id: 185431:Tb10.61.0380
uniprot id: Q387S3
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.3.1630
gene id: 185431:Tb927.3.1630
uniprot id: Q57ZE8
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.7.220
gene id: 185431:Tb927.7.220
uniprot id: Q57U32
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

185431:Tb927.7.4470
gene id: 185431:Tb927.7.4470
uniprot id: Q57X63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

185431:Tb10.6k15.2040
gene id: 185431:Tb10.6k15.2040
uniprot id: Q38AC0
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

185431:Tb10.6k15.1820
gene id: 185431:Tb10.6k15.1820
uniprot id: Q38AA1
names: Similarity
messages: Belongs to the CNOT10 family.

185431:Tb927.6.4590
gene id: 185431:Tb927.6.4590
uniprot id: Q587C5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

185431:Tb927.5.4210
gene id: 185431:Tb927.5.4210
uniprot id: Q57Z31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the histone H4 family.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb10.6k15.3030
gene id: 185431:Tb10.6k15.3030
uniprot id: Q38AK2
names: Similarity
messages: Belongs to the AAA ATPase family.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

185431:Tb10.100.0130
gene id: 185431:Tb10.100.0130
uniprot id: Q38CL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the peroxisomal translocation machinery.
messages: Peroxisome membrane

185431:Tb10.70.0720
gene id: 185431:Tb10.70.0720
uniprot id: Q38AZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

185431:Tb10.70.6340
gene id: 185431:Tb10.70.6340
uniprot id: Q38C84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

185431:Tb09.211.3470
gene id: 185431:Tb09.211.3470
uniprot id: Q38DF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

185431:Tb927.2.3190
gene id: 185431:Tb927.2.3190
uniprot id: Q587F6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

185431:Tb10.70.6325
gene id: 185431:Tb10.70.6325
uniprot id: Q38C82
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

185431:Tb927.8.6680
gene id: 185431:Tb927.8.6680
uniprot id: Q57TU5
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

185431:Tb10.70.2680
gene id: 185431:Tb10.70.2680
uniprot id: Q38BE7
names: Similarity
messages: Belongs to the ARPC3 family.

185431:Tb09.160.2360
gene id: 185431:Tb09.160.2360
uniprot id: Q38FF7
names: Similarity
messages: Belongs to the WD repeat rae1 family.

185431:Tb927.5.500
gene id: 185431:Tb927.5.500
uniprot id: Q57VW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC7 family.
messages: cilium axoneme
messages: flagellum

185431:Tb927.7.4770
gene id: 185431:Tb927.7.4770
uniprot id: Q57X93
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

185431:Tb09.244.2330
gene id: 185431:Tb09.244.2330
uniprot id: Q38CU4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.7.2830
gene id: 185431:Tb927.7.2830
uniprot id: Q57YA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb10.70.0090
gene id: 185431:Tb10.70.0090
uniprot id: Q38AT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

185431:Tb10.70.5090
gene id: 185431:Tb10.70.5090
uniprot id: Q38BY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP17 family.
messages: nucleolus

185431:Tb10.389.1550
gene id: 185431:Tb10.389.1550
uniprot id: Q389C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

185431:Tb927.5.3600
gene id: 185431:Tb927.5.3600
uniprot id: Q57UA6
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.

185431:Tb927.5.3270
gene id: 185431:Tb927.5.3270
uniprot id: Q57Z66
names: Similarity
messages: Belongs to the beclin family.

185431:Tb10.6k15.1850
gene id: 185431:Tb10.6k15.1850
uniprot id: Q38AA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

185431:Tb927.4.430
gene id: 185431:Tb927.4.430
uniprot id: D6XEX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

185431:Tb10.61.1390
gene id: 185431:Tb10.61.1390
uniprot id: Q586C2
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

185431:Tb09.211.2860
gene id: 185431:Tb09.211.2860
uniprot id: Q38DL9
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

185431:Tb927.3.870
gene id: 185431:Tb927.3.870
uniprot id: Q57WX0
names: Similarity
messages: Belongs to the SLBP family.

185431:Tb927.8.6810
gene id: 185431:Tb927.8.6810
uniprot id: Q57TT2
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.7.2500
gene id: 185431:Tb927.7.2500
uniprot id: D6XKG7
names: Similarity
messages: Belongs to the AAA ATPase family.

185431:Tb10.406.0130
gene id: 185431:Tb10.406.0130
uniprot id: Q389Q3
names: Similarity
messages: Belongs to the peptidase M14 family.

185431:Tb927.2.2450
gene id: 185431:Tb927.2.2450
uniprot id: Q586L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

185431:Tb10.6k15.1400
gene id: 185431:Tb10.6k15.1400
uniprot id: Q38A71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

185431:Tb927.3.3580
gene id: 185431:Tb927.3.3580
uniprot id: Q57W94
names: Similarity
messages: Belongs to the heat shock protein 90 family.

185431:Tb927.7.3890
gene id: 185431:Tb927.7.3890
uniprot id: Q57UL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

185431:Tb927.5.2690
gene id: 185431:Tb927.5.2690
uniprot id: Q57ZU5
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

185431:Tb10.70.3510
gene id: 185431:Tb10.70.3510
uniprot id: Q382C4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

185431:Tb927.4.1800
gene id: 185431:Tb927.4.1800
uniprot id: Q581Q1
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

185431:Tb927.6.2330
gene id: 185431:Tb927.6.2330
uniprot id: Q584S3
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

185431:Tb10.70.6480
gene id: 185431:Tb10.70.6480
uniprot id: Q38C92
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although it belongs to the XPG/RAD2 endonuclease family, only one of the seven Asp residues involved in Mg(2+) binding is conserved suggesting that it has no nuclease activity.
messages: Belongs to the XPG/RAD2 endonuclease family.
messages: Cytoplasm
messages: Expressed in the procyclic and bloodstream forms (at protein level).
messages: Forms a complex composed of at least MKT1L, PBP1, XAC1 and LSM12.
messages: Involved in post-transcriptional regulation of gene expression.
messages: RNAi-mediated knockdown in both the procyclic and the bloodstream form is lethal.

185431:Tb927.5.4530
gene id: 185431:Tb927.5.4530
uniprot id: Q57X51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

185431:Tb927.8.3220
gene id: 185431:Tb927.8.3220
uniprot id: Q57YZ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

185431:Tb10.389.0140
gene id: 185431:Tb10.389.0140
uniprot id: Q388R8
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

185431:Tb10.70.7695
gene id: 185431:Tb10.70.7695
uniprot id: Q38CI4
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

185431:Tb927.5.520
gene id: 185431:Tb927.5.520
uniprot id: Q57VW1
names: Similarity
messages: Belongs to the band 7/mec-2 family.

185431:Tb10.70.1130
gene id: 185431:Tb10.70.1130
uniprot id: Q38B23
names: Similarity
messages: Belongs to the CFAP36 family.

185431:Tb10.389.0730
gene id: 185431:Tb10.389.0730
uniprot id: Q388W5
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Belongs to the cytidylyltransferase family.

185431:Tb10.6k15.0410
gene id: 185431:Tb10.6k15.0410
uniprot id: P50885
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Cytoplasm

185431:Tb10.61.2840
gene id: 185431:Tb10.61.2840
uniprot id: Q388J5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.

185431:Tb927.8.6740
gene id: 185431:Tb927.8.6740
uniprot id: Q57TT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

185431:Tb10.61.1830
gene id: 185431:Tb10.61.1830
uniprot id: Q388C4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

185431:Tb10.70.2210
gene id: 185431:Tb10.70.2210
uniprot id: Q38BA2
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.4.4890
gene id: 185431:Tb927.4.4890
uniprot id: Q584L6
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.5.4320
gene id: 185431:Tb927.5.4320
uniprot id: Q57Z17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

185431:TB927.1.630
gene id: 185431:TB927.1.630
uniprot id: Q4GZF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

185431:Tb927.8.7300
gene id: 185431:Tb927.8.7300
uniprot id: Q57YT2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.8.5380
gene id: 185431:Tb927.8.5380
uniprot id: Q57UL0
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier.

185431:Tb10.70.0670
gene id: 185431:Tb10.70.0670
uniprot id: Q38AZ0
names: Similarity
messages: Belongs to the COG3 family.

185431:Tb927.4.660
gene id: 185431:Tb927.4.660
uniprot id: Q57ZZ4
names: Similarity
messages: Belongs to the DNAI7 family.

185431:Tb927.8.2580
gene id: 185431:Tb927.8.2580
uniprot id: Q57XD1
names: Function
names: Similarity
messages: Belongs to the SEC10 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

185431:Tb10.6k15.1620
gene id: 185431:Tb10.6k15.1620
uniprot id: Q38A87
names: Similarity
messages: Belongs to the taxilin family.

185431:Tb09.211.4330
gene id: 185431:Tb09.211.4330
uniprot id: Q38D78
names: Similarity
messages: Belongs to the peptidase M24B family.

185431:Tb927.5.2410
gene id: 185431:Tb927.5.2410
uniprot id: Q582C4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Ungrouped subfamily.

185431:Tb927.7.180
gene id: 185431:Tb927.7.180
uniprot id: Q57U36
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.6.2300
gene id: 185431:Tb927.6.2300
uniprot id: Q584S6
names: Function
names: Similarity
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.

185431:Tb10.6k15.0040
gene id: 185431:Tb10.6k15.0040
uniprot id: Q389V3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

185431:Tb927.6.4280
gene id: 185431:Tb927.6.4280
uniprot id: Q586Z5
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

185431:Tb927.8.5570
gene id: 185431:Tb927.8.5570
uniprot id: Q57X25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69.2) family.
messages: Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.
messages: Membrane

185431:Tb10.70.1780
gene id: 185431:Tb10.70.1780
uniprot id: Q38B74
names: Similarity
messages: Belongs to the NifU family.

185431:Tb927.7.2860
gene id: 185431:Tb927.7.2860
uniprot id: Q57YA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.7.1740
gene id: 185431:Tb927.7.1740
uniprot id: Q57V35
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

185431:Tb10.61.1960
gene id: 185431:Tb10.61.1960
uniprot id: Q388D3
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

185431:Tb927.7.2820
gene id: 185431:Tb927.7.2820
uniprot id: Q57YA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb09.160.3820
gene id: 185431:Tb09.160.3820
uniprot id: Q38F23
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

185431:Tb927.7.3560
gene id: 185431:Tb927.7.3560
uniprot id: Q57WH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP44 family.
messages: Flagellar protein involved in flagellum axoneme organization and function.
messages: flagellum
messages: flagellum axoneme

185431:Tb10.70.2570
gene id: 185431:Tb10.70.2570
uniprot id: Q38BD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit L family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

185431:Tb10.70.3125
gene id: 185431:Tb10.70.3125
uniprot id: Q38BI6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

185431:Tb09.244.2820
gene id: 185431:Tb09.244.2820
uniprot id: Q38CZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus

185431:Tb927.5.4200
gene id: 185431:Tb927.5.4200
uniprot id: Q57Z31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the histone H4 family.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb09.160.1140
gene id: 185431:Tb09.160.1140
uniprot id: Q38FS2
names: Similarity
messages: Belongs to the SCO1/2 family.

185431:Tb10.61.2410
gene id: 185431:Tb10.61.2410
uniprot id: Q388G6
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

185431:Tb09.211.2650
gene id: 185431:Tb09.211.2650
uniprot id: Q38DN9
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

185431:Tb927.2.5750
gene id: 185431:Tb927.2.5750
uniprot id: Q586D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

185431:Tb927.6.4690
gene id: 185431:Tb927.6.4690
uniprot id: Q587D5
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

185431:Tb927.3.1910
gene id: 185431:Tb927.3.1910
uniprot id: Q57ZC0
names: Similarity
messages: Belongs to the SLBP family.

185431:Tb927.8.5960
gene id: 185431:Tb927.8.5960
uniprot id: Q57YJ7
names: Similarity
messages: Belongs to the UPF0610 family.

185431:Tb927.5.1520
gene id: 185431:Tb927.5.1520
uniprot id: Q57VB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex (HslVU) is dependent on binding of ATP (By similarity).
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity). The HslVU protease complex functions in mitochondrial DNA replication by regulating DNA helicase PIF2 protein levels.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: kinetoplast

185431:Tb927.8.6640
gene id: 185431:Tb927.8.6640
uniprot id: Q57TU9
names: Function
names: Similarity
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.

185431:Tb927.3.2020
gene id: 185431:Tb927.3.2020
uniprot id: Q57ZA9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb10.389.0510
gene id: 185431:Tb10.389.0510
uniprot id: Q388U6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

185431:Tb927.7.5310
gene id: 185431:Tb927.7.5310
uniprot id: Q57ZF8
names: Subcellular Location Annotation
messages: Cytoplasm

185431:Tb10.406.0110
gene id: 185431:Tb10.406.0110
uniprot id: Q389Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAP2/GCS1 family.
messages: Cell membrane
messages: Membrane

185431:Tb10.6k15.3640
gene id: 185431:Tb10.6k15.3640
uniprot id: Q38AQ4
names: Cofactor
names: Similarity
messages: Belongs to the alternative oxidase family.
messages: Binds 2 iron ions per subunit.

185431:Tb10.70.2190
gene id: 185431:Tb10.70.2190
uniprot id: Q38BA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Mitochondrion

185431:Tb927.6.4950
gene id: 185431:Tb927.6.4950
uniprot id: Q586G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

185431:Tb927.8.2960
gene id: 185431:Tb927.8.2960
uniprot id: Q57W77
names: Function
names: Similarity
messages: Belongs to the BMT2 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase.

185431:Tb927.4.1250
gene id: 185431:Tb927.4.1250
uniprot id: Q581V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

185431:Tb10.26.0560
gene id: 185431:Tb10.26.0560
uniprot id: Q389K1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

185431:Tb927.8.630
gene id: 185431:Tb927.8.630
uniprot id: Q57YG7
names: Similarity
messages: Belongs to the LplA family.

185431:Tb10.70.0350
gene id: 185431:Tb10.70.0350
uniprot id: Q38AW0
names: Similarity
messages: Belongs to the PPP phosphatase family.

185431:Tb927.5.650
gene id: 185431:Tb927.5.650
uniprot id: Q57VF3
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.3.5530
gene id: 185431:Tb927.3.5530
uniprot id: Q580S2
names: Similarity
messages: Belongs to the DOCK family.

185431:Tb927.7.7130
gene id: 185431:Tb927.7.7130
uniprot id: Q57XT3
names: Similarity
messages: Belongs to the TYW1 family.

185431:Tb10.70.1900
gene id: 185431:Tb10.70.1900
uniprot id: Q38B82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

185431:Tb927.2.5660
gene id: 185431:Tb927.2.5660
uniprot id: Q586D5
names: Similarity
messages: Belongs to the adenylate kinase family.

185431:Tb927.8.3800
gene id: 185431:Tb927.8.3800
uniprot id: D6XLB5
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

185431:TB927.1.600
gene id: 185431:TB927.1.600
uniprot id: Q4GZF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

185431:Tb927.8.800
gene id: 185431:Tb927.8.800
uniprot id: Q57YF1
names: Similarity
messages: Belongs to the BLM10 family.

185431:Tb927.8.3980
gene id: 185431:Tb927.8.3980
uniprot id: Q581B8
names: Subcellular Location Annotation
messages: Nucleus

185431:Tb09.244.1000
gene id: 185431:Tb09.244.1000
uniprot id: Q38CP6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.5.4430
gene id: 185431:Tb927.5.4430
uniprot id: Q57Z06
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb10.26.0370
gene id: 185431:Tb10.26.0370
uniprot id: Q389I7
names: Similarity
messages: Belongs to the universal ribosomal protein uS3 family.

185431:Tb10.61.2910
gene id: 185431:Tb10.61.2910
uniprot id: Q388K2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Nucleus

185431:Tb927.7.3380
gene id: 185431:Tb927.7.3380
uniprot id: Q57WF3
names: Similarity
messages: Belongs to the MAK16 family.

185431:Tb927.8.2380
gene id: 185431:Tb927.8.2380
uniprot id: Q57XF1
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.6k15.3470
gene id: 185431:Tb10.6k15.3470
uniprot id: Q38AP1
names: Similarity
messages: Belongs to the TOP6A family.

185431:Tb927.3.1100
gene id: 185431:Tb927.3.1100
uniprot id: Q57WZ1
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

185431:Tb927.5.4230
gene id: 185431:Tb927.5.4230
uniprot id: Q57Z31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the histone H4 family.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.4.1660
gene id: 185431:Tb927.4.1660
uniprot id: Q581R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

185431:Tb09.211.2190
gene id: 185431:Tb09.211.2190
uniprot id: Q38DT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

185431:Tb927.3.1150
gene id: 185431:Tb927.3.1150
uniprot id: Q57WZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

185431:Tb927.5.1150
gene id: 185431:Tb927.5.1150
uniprot id: D6XG53
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

185431:Tb10.70.0040
gene id: 185431:Tb10.70.0040
uniprot id: Q38AT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

185431:Tb927.4.4490
gene id: 185431:Tb927.4.4490
uniprot id: Q583D4
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.6.1380
gene id: 185431:Tb927.6.1380
uniprot id: Q585B1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

185431:Tb09.211.4490
gene id: 185431:Tb09.211.4490
uniprot id: Q38D64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

185431:Tb927.6.3520
gene id: 185431:Tb927.6.3520
uniprot id: Q584Z2
names: Similarity
messages: Belongs to the RMD1/sif2 family.

185431:Tb927.5.5080
gene id: 185431:Tb927.5.5080
uniprot id: Q57UD8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.4.5560
gene id: 185431:Tb927.4.5560
uniprot id: Q580P0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.3.950
gene id: 185431:Tb927.3.950
uniprot id: Q57WX8
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

185431:Tb927.3.1380
gene id: 185431:Tb927.3.1380
uniprot id: Q57XX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

185431:Tb927.8.7920
gene id: 185431:Tb927.8.7920
uniprot id: Q57U53
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.3.2480
gene id: 185431:Tb927.3.2480
uniprot id: Q582W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane
messages: Regulates also the sphingolipid metabolism.

185431:Tb927.3.3810
gene id: 185431:Tb927.3.3810
uniprot id: Q57WB7
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.7.7420
gene id: 185431:Tb927.7.7420
uniprot id: Q57TX9
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

185431:Tb09.160.5560
gene id: 185431:Tb09.160.5560
uniprot id: Q38EJ2
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

185431:Tb927.7.5670
gene id: 185431:Tb927.7.5670
uniprot id: Q582I2
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

185431:Tb09.354.0180
gene id: 185431:Tb09.354.0180
uniprot id: Q38G45
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb09.244.1600
gene id: 185431:Tb09.244.1600
uniprot id: Q38CQ3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:TB927.1.2040
gene id: 185431:TB927.1.2040
uniprot id: Q4GZ15
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.8.5020
gene id: 185431:Tb927.8.5020
uniprot id: Q57UH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC10 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
messages: flagellum axoneme

185431:Tb927.7.2920
gene id: 185431:Tb927.7.2920
uniprot id: Q57YA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb09.v1.0350
gene id: 185431:Tb09.v1.0350
uniprot id: Q38EH9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

185431:Tb927.7.5090
gene id: 185431:Tb927.7.5090
uniprot id: Q57ZI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm

185431:Tb927.7.7290
gene id: 185431:Tb927.7.7290
uniprot id: D6XJQ7
names: Similarity
messages: Belongs to the COG4 family.

185431:Tb10.6k15.0580
gene id: 185431:Tb10.6k15.0580
uniprot id: Q38A02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

185431:Tb10.70.0970
gene id: 185431:Tb10.70.0970
uniprot id: Q38B11
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.6.2360
gene id: 185431:Tb927.6.2360
uniprot id: Q584S0
names: Function
names: Similarity
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.

185431:Tb927.6.4480
gene id: 185431:Tb927.6.4480
uniprot id: Q587B4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

185431:Tb927.8.2310
gene id: 185431:Tb927.8.2310
uniprot id: Q57XF8
names: Similarity
messages: Belongs to the V-ATPase G subunit family.

185431:Tb09.211.1020
gene id: 185431:Tb09.211.1020
uniprot id: Q38E54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Bidirectional lipid ethanolaminephosphotransferase capable of converting phosphatidylethanolamine (PE) and ceramide to ethanolamine-phosphorylceramide (EPC) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphoethanolamine acceptors. Does not function strictly as a SM synthase. Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target (By similarity).
messages: Membrane

185431:Tb09.244.2760
gene id: 185431:Tb09.244.2760
uniprot id: Q38CZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

185431:Tb927.3.2840
gene id: 185431:Tb927.3.2840
uniprot id: Q57ZM8
names: Similarity
messages: Belongs to the PPase family.

185431:Tb09.160.3510
gene id: 185431:Tb09.160.3510
uniprot id: Q38F54
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

185431:Tb10.389.1530
gene id: 185431:Tb10.389.1530
uniprot id: Q389C2
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

185431:Tb927.6.4060
gene id: 185431:Tb927.6.4060
uniprot id: Q586A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Membrane

185431:Tb10.406.0460
gene id: 185431:Tb10.406.0460
uniprot id: Q389T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.2.2900
gene id: 185431:Tb927.2.2900
uniprot id: Q587H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

185431:Tb09.160.1010
gene id: 185431:Tb09.160.1010
uniprot id: Q38FT6
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.100.0150
gene id: 185431:Tb10.100.0150
uniprot id: Q38CL2
names: Similarity
messages: Belongs to the BolA/IbaG family.

185431:Tb927.5.3400
gene id: 185431:Tb927.5.3400
uniprot id: Q57Z55
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

185431:Tb10.70.3020
gene id: 185431:Tb10.70.3020
uniprot id: Q38BH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

185431:Tb927.4.3620
gene id: 185431:Tb927.4.3620
uniprot id: Q585I8
names: Similarity
messages: Belongs to the PPP phosphatase family.

185431:Tb927.7.2800
gene id: 185431:Tb927.7.2800
uniprot id: Q57Y90
names: Similarity
messages: Belongs to the PRP18 family.

185431:Tb10.6k15.3160
gene id: 185431:Tb10.6k15.3160
uniprot id: Q38AL4
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

185431:Tb09.211.3310
gene id: 185431:Tb09.211.3310
uniprot id: Q38DH5
names: Similarity
messages: Belongs to the activator 1 small subunits family.

185431:Tb927.8.7380
gene id: 185431:Tb927.8.7380
uniprot id: Q57YU0
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

185431:Tb10.70.5130
gene id: 185431:Tb10.70.5130
uniprot id: Q38BZ1
names: Similarity
messages: Belongs to the adenylate kinase family.

185431:Tb09.211.3550
gene id: 185431:Tb09.211.3550
uniprot id: Q38DF2
names: Similarity
messages: Belongs to the FGGY kinase family.

185431:Tb10.05.0200
gene id: 185431:Tb10.05.0200
uniprot id: Q388Q0
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.4.1320
gene id: 185431:Tb927.4.1320
uniprot id: Q581U9
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

185431:Tb927.2.5020
gene id: 185431:Tb927.2.5020
uniprot id: Q586U0
names: Similarity
messages: Belongs to the acyl-CoA oxidase family.

185431:Tb10.70.0430
gene id: 185431:Tb10.70.0430
uniprot id: Q38AV5
names: Function
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.
messages: Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.

185431:Tb927.6.1250
gene id: 185431:Tb927.6.1250
uniprot id: Q585C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

185431:Tb927.7.1500
gene id: 185431:Tb927.7.1500
uniprot id: Q57WQ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.

185431:Tb09.211.4550
gene id: 185431:Tb09.211.4550
uniprot id: Q38D53
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

185431:Tb927.8.7280
gene id: 185431:Tb927.8.7280
uniprot id: Q57YT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

185431:Tb927.2.4370
gene id: 185431:Tb927.2.4370
uniprot id: Q586P2
names: Similarity
messages: In the C-terminal section; belongs to the glutathionylspermidine synthase preATP-grasp family.

185431:Tb10.61.0500
gene id: 185431:Tb10.61.0500
uniprot id: Q387T4
names: Similarity
messages: Belongs to the actin family.

185431:Tb927.3.4630
gene id: 185431:Tb927.3.4630
uniprot id: Q582S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

185431:Tb10.6k15.3140
gene id: 185431:Tb10.6k15.3140
uniprot id: Q38AL2
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

185431:Tb927.7.1020
gene id: 185431:Tb927.7.1020
uniprot id: Q57VU8
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

185431:Tb927.3.4880
gene id: 185431:Tb927.3.4880
uniprot id: Q582P7
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

185431:Tb927.7.3830
gene id: 185431:Tb927.7.3830
uniprot id: Q57UD0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.4.3290
gene id: 185431:Tb927.4.3290
uniprot id: Q584A6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.2.6210
gene id: 185431:Tb927.2.6210
uniprot id: Q586N2
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

185431:Tb927.2.3930
gene id: 185431:Tb927.2.3930
uniprot id: Q586W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

185431:Tb10.70.0520
gene id: 185431:Tb10.70.0520
uniprot id: Q38AX5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Nucleus
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport.
messages: The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs).

185431:Tb09.v1.0290
gene id: 185431:Tb09.v1.0290
uniprot id: Q38EK9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.61.2510
gene id: 185431:Tb10.61.2510
uniprot id: Q388H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

185431:Tb927.3.3360
gene id: 185431:Tb927.3.3360
uniprot id: Q57V50
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

185431:Tb927.5.4840
gene id: 185431:Tb927.5.4840
uniprot id: Q57X36
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.6.3630
gene id: 185431:Tb927.6.3630
uniprot id: Q585W1
names: Similarity
messages: Belongs to the group II decarboxylase family.

185431:Tb09.244.0470
gene id: 185431:Tb09.244.0470
uniprot id: Q38CP0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.6k15.1160
gene id: 185431:Tb10.6k15.1160
uniprot id: Q38A49
names: Similarity
messages: Belongs to the CAP family.

185431:Tb927.8.3120
gene id: 185431:Tb927.8.3120
uniprot id: Q57W61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM234 family.
messages: Membrane

185431:Tb10.389.1170
gene id: 185431:Tb10.389.1170
uniprot id: Q388Z2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb09.211.0775
gene id: 185431:Tb09.211.0775
uniprot id: Q38E79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMY1 family.
messages: Nucleus

185431:Tb927.4.3740
gene id: 185431:Tb927.4.3740
uniprot id: Q585H6
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: A component of FAZ filament that is required for correct FAZ assembly and attachment. Not essential for new flagellum growth.
messages: Assembly of a compromised FAZ and defects in flagellum attachment and cytokinesis in procyclic trypanosomes resulting in generation of 0N1K cells (zoids) and multinucleated cells, demonstrates the role of an attached flagellum in cellular morphogenesis.
messages: flagellum

185431:Tb927.7.4400
gene id: 185431:Tb927.7.4400
uniprot id: Q57X56
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

185431:Tb927.8.3330
gene id: 185431:Tb927.8.3330
uniprot id: Q57YY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

185431:Tb927.6.3310
gene id: 185431:Tb927.6.3310
uniprot id: Q584X4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb927.7.3600
gene id: 185431:Tb927.7.3600
uniprot id: Q57WH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

185431:Tb09.211.0740
gene id: 185431:Tb09.211.0740
uniprot id: Q38E83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LSM12 family.
messages: Forms a complex composed of at least MKT1, PBP1, XAC1 and LSM12 (PubMed:24470144). Forms a complex composed of at least MKT1L, PBP1, XAC1 and LSM12 (PubMed:32532821). Within the complex, interacts with PBP1; the interaction is direct (PubMed:24470144, PubMed:32532821).
messages: Involved in post-transcriptional regulation of gene expression.

185431:Tb927.7.1510
gene id: 185431:Tb927.7.1510
uniprot id: Q57WP9
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

185431:Tb927.3.1310
gene id: 185431:Tb927.3.1310
uniprot id: Q57XW4
names: Similarity
messages: Belongs to the WD repeat mio family.

185431:Tb927.7.7040
gene id: 185431:Tb927.7.7040
uniprot id: Q57XS4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

185431:Tb10.70.0850
gene id: 185431:Tb10.70.0850
uniprot id: Q38B02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.

185431:Tb927.8.3430
gene id: 185431:Tb927.8.3430
uniprot id: Q57YX0
names: Subcellular Location Annotation
messages: cilium basal body

185431:Tb927.8.7050
gene id: 185431:Tb927.8.7050
uniprot id: Q57YR2
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

185431:TB927.1.700
gene id: 185431:TB927.1.700
uniprot id: Q4GZG4
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

185431:Tb10.61.2640
gene id: 185431:Tb10.61.2640
uniprot id: Q388I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

185431:Tb927.6.330
gene id: 185431:Tb927.6.330
uniprot id: Q581E4
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.4.690
gene id: 185431:Tb927.4.690
uniprot id: Q57ZZ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

185431:Tb10.26.0570
gene id: 185431:Tb10.26.0570
uniprot id: Q389K2
names: Similarity
messages: Belongs to the TTC4 family.

185431:Tb927.8.4890
gene id: 185431:Tb927.8.4890
uniprot id: Q57UW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

185431:Tb10.70.4720
gene id: 185431:Tb10.70.4720
uniprot id: Q38BV5
names: Subcellular Location Annotation
messages: Cytoplasm

185431:Tb09.160.1980
gene id: 185431:Tb09.160.1980
uniprot id: Q38FJ5
names: Similarity
messages: Belongs to the SERF family.

185431:Tb10.70.5600
gene id: 185431:Tb10.70.5600
uniprot id: Q38C29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

185431:Tb10.70.2920
gene id: 185431:Tb10.70.2920
uniprot id: Q4FKP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

185431:Tb10.26.1030
gene id: 185431:Tb10.26.1030
uniprot id: Q389N7
names: Subcellular Location Annotation
messages: Nucleus

185431:Tb10.389.1570
gene id: 185431:Tb10.389.1570
uniprot id: Q389C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

185431:Tb927.8.170
gene id: 185431:Tb927.8.170
uniprot id: Q57XI7
names: Function
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.100.0110
gene id: 185431:Tb10.100.0110
uniprot id: Q38AW9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

185431:Tb927.4.4760
gene id: 185431:Tb927.4.4760
uniprot id: Q583G1
names: Similarity
messages: Belongs to the cullin family.

185431:Tb927.4.1480
gene id: 185431:Tb927.4.1480
uniprot id: Q581T3
names: Subcellular Location Annotation
messages: Nucleus

185431:Tb927.7.710
gene id: 185431:Tb927.7.710
uniprot id: Q57VR7
names: Similarity
messages: Belongs to the heat shock protein 70 family.

185431:Tb10.61.3210
gene id: 185431:Tb10.61.3210
uniprot id: Q388M8
names: Similarity
messages: Belongs to the AHA1 family.

185431:TB927.1.3130
gene id: 185431:TB927.1.3130
uniprot id: Q4GYR0
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.3.910
gene id: 185431:Tb927.3.910
uniprot id: D6XD01
names: Function
names: Similarity
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.

185431:Tb927.5.790
gene id: 185431:Tb927.5.790
uniprot id: Q57W24
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb10.70.5050
gene id: 185431:Tb10.70.5050
uniprot id: Q38BY3
names: Similarity
messages: Belongs to the p23/wos2 family.

185431:Tb927.4.4600
gene id: 185431:Tb927.4.4600
uniprot id: Q583E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

185431:Tb927.8.6930
gene id: 185431:Tb927.8.6930
uniprot id: Q57YQ0
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.5.3610
gene id: 185431:Tb927.5.3610
uniprot id: Q57UA5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer.
messages: Belongs to the adaptor complexes large subunit family.
messages: Golgi apparatus

185431:TB927.1.3950
gene id: 185431:TB927.1.3950
uniprot id: Q4GYI2
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

185431:Tb10.389.1790
gene id: 185431:Tb10.389.1790
uniprot id: Q389E3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

185431:Tb927.7.4570
gene id: 185431:Tb927.7.4570
uniprot id: Q57X73
names: Similarity
messages: Belongs to the IUNH family.

185431:Tb927.7.2940
gene id: 185431:Tb927.7.2940
uniprot id: Q57YA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.6.190
gene id: 185431:Tb927.6.190
uniprot id: Q57WZ8
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.3.4680
gene id: 185431:Tb927.3.4680
uniprot id: Q582R7
names: Similarity
messages: Belongs to the Rab GDI family.

185431:Tb09.211.3560
gene id: 185431:Tb09.211.3560
uniprot id: Q38DE9
names: Similarity
messages: Belongs to the FGGY kinase family.

185431:Tb927.8.6830
gene id: 185431:Tb927.8.6830
uniprot id: Q57TT0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.4.3880
gene id: 185431:Tb927.4.3880
uniprot id: Q57XZ2
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.7.5770
gene id: 185431:Tb927.7.5770
uniprot id: Q582J2
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb10.26.1080
gene id: 185431:Tb10.26.1080
uniprot id: Q389P1
names: Similarity
messages: Belongs to the heat shock protein 90 family.

185431:Tb927.2.6150
gene id: 185431:Tb927.2.6150
uniprot id: Q586N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

185431:Tb927.8.4040
gene id: 185431:Tb927.8.4040
uniprot id: Q581C4
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

185431:Tb927.6.5050
gene id: 185431:Tb927.6.5050
uniprot id: Q586H7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

185431:Tb927.7.210
gene id: 185431:Tb927.7.210
uniprot id: Q57U33
names: Function
names: Similarity
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate.

185431:Tb927.7.6900
gene id: 185431:Tb927.7.6900
uniprot id: Q57XR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

185431:Tb927.5.2940
gene id: 185431:Tb927.5.2940
uniprot id: Q57ZX0
names: Subcellular Location Annotation
messages: Cytoplasm

185431:Tb927.4.2700
gene id: 185431:Tb927.4.2700
uniprot id: D6XFK6
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

185431:Tb09.211.2300
gene id: 185431:Tb09.211.2300
uniprot id: Q38DS7
names: Similarity
messages: Belongs to the DEAD box helicase family.

185431:Tb927.8.5970
gene id: 185431:Tb927.8.5970
uniprot id: Q57YJ8
names: Similarity
messages: Belongs to the cullin family.

185431:Tb927.5.330
gene id: 185431:Tb927.5.330
uniprot id: Q57VY0
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb10.406.0330
gene id: 185431:Tb10.406.0330
uniprot id: Q389T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.7.230
gene id: 185431:Tb927.7.230
uniprot id: Q57U30
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

185431:Tb927.4.4290
gene id: 185431:Tb927.4.4290
uniprot id: Q57Y33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb10.61.1090
gene id: 185431:Tb10.61.1090
uniprot id: Q387X7
names: Similarity
messages: Belongs to the histone H3 family.

185431:Tb09.211.4440
gene id: 185431:Tb09.211.4440
uniprot id: Q38D67
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.3.5680
gene id: 185431:Tb927.3.5680
uniprot id: Q57VH5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.6k15.1960
gene id: 185431:Tb10.6k15.1960
uniprot id: Q38AB4
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

185431:Tb10.70.3240
gene id: 185431:Tb10.70.3240
uniprot id: Q38BJ6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

185431:Tb927.2.1560
gene id: 185431:Tb927.2.1560
uniprot id: Q585R7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

185431:Tb927.6.2460
gene id: 185431:Tb927.6.2460
uniprot id: Q584R0
names: Subcellular Location Annotation
messages: Cytoplasm

185431:Tb10.6k15.3020
gene id: 185431:Tb10.6k15.3020
uniprot id: Q38AK1
names: Subcellular Location Annotation
messages: Cytoplasm

185431:Tb927.3.4000
gene id: 185431:Tb927.3.4000
uniprot id: Q57WD6
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

185431:Tb927.8.4540
gene id: 185431:Tb927.8.4540
uniprot id: Q57UZ7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ataxin-2 family.
messages: Expressed in the procyclic and bloodstream forms (at protein level).
messages: Forms a complex composed of at least MKT1, PBP1, XAC1 and LSM12 (PubMed:32532821). Forms a complex composed of at least MKT1L, PBP1, XAC1 and LSM12 (PubMed:32532821). Within the complex, interacts with MKT1 (via C-terminus); the interaction is direct (PubMed:24470144, PubMed:32532821). Interacts (via C-terminus) with ZC3H11; the interaction is direct (PubMed:24470144).
messages: Involved in post-transcriptional regulation of gene expression (PubMed:24470144). Promotes mRNA stabilization by bridging poly(A)-binding protein to mRNAs (PubMed:24470144).
messages: Stress granule
messages: cytosol

185431:Tb09.160.4590
gene id: 185431:Tb09.160.4590
uniprot id: Q38EU9
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

185431:Tb927.8.3740
gene id: 185431:Tb927.8.3740
uniprot id: Q580Z4
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

185431:TB927.1.1130
gene id: 185431:TB927.1.1130
uniprot id: Q4GZA5
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

185431:Tb09.160.4700
gene id: 185431:Tb09.160.4700
uniprot id: Q38ET6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-16 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Peroxisome membrane

185431:Tb927.8.6170
gene id: 185431:Tb927.8.6170
uniprot id: Q57YL8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

185431:Tb10.406.0290
gene id: 185431:Tb10.406.0290
uniprot id: Q389R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Membrane

185431:Tb10.406.0360
gene id: 185431:Tb10.406.0360
uniprot id: Q389T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb10.6k15.0060
gene id: 185431:Tb10.6k15.0060
uniprot id: Q389V5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

185431:Tb927.3.4810
gene id: 185431:Tb927.3.4810
uniprot id: Q582Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Nucleus

185431:Tb10.70.3370
gene id: 185431:Tb10.70.3370
uniprot id: Q38BK7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).
messages: Cytoplasm

185431:Tb927.2.6310
gene id: 185431:Tb927.2.6310
uniprot id: Q586M6
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

185431:Tb927.7.3520
gene id: 185431:Tb927.7.3520
uniprot id: Q57WG7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

185431:Tb927.7.3770
gene id: 185431:Tb927.7.3770
uniprot id: Q57WJ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

185431:Tb927.6.940
gene id: 185431:Tb927.6.940
uniprot id: Q585F3
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by Ca(2+) (PubMed:18005666, PubMed:23506317, PubMed:28089596, PubMed:22529389). In response to calcium binding, the 280-loop, a disordered loop consisting of residues 269-275, undergoes a conformational change which stabilizes substrates in the active site (PubMed:22529389). The binding to the substrate triggers the release of the N-terminal region resulting in the activation of the enzyme (PubMed:22529389). Proteolytic cleavage is required for catalytic activity towards large protein substrates (PubMed:28089596).
messages: Auto-proteolytic cleavage of the propeptide after Lys-55 and between the large and small subunits after Lys-268 is required for catalytic activity towards large protein substrates but is dispensable towards small oligopeptide substrates (PubMed:18005666, PubMed:28089596, PubMed:22529389). After processing, the propeptide and the large and small subunits remain associated by non-covalent bonds (PubMed:18005666). In vivo, the unprocessed enzyme appears to be the predominant form (By similarity).
messages: Belongs to the peptidase C14B family.
messages: Cysteine protease that cleaves specifically after arginine or lysine residues.
messages: Monomer.
messages: Recycling endosome
messages: There are 2 calcium binding sites with high and low affinity, respectively.

185431:Tb10.70.7550
gene id: 185431:Tb10.70.7550
uniprot id: Q38CH4
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

185431:Tb927.3.2040
gene id: 185431:Tb927.3.2040
uniprot id: Q57ZA7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb10.389.0130
gene id: 185431:Tb10.389.0130
uniprot id: Q388R7
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

185431:Tb927.8.1620
gene id: 185431:Tb927.8.1620
uniprot id: Q580G0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

185431:Tb927.3.1470
gene id: 185431:Tb927.3.1470
uniprot id: Q57XY0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.7.2050
gene id: 185431:Tb927.7.2050
uniprot id: Q57V06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

185431:Tb927.8.1410
gene id: 185431:Tb927.8.1410
uniprot id: Q580I2
names: Subcellular Location Annotation
messages: nucleolus

185431:Tb10.70.5630
gene id: 185431:Tb10.70.5630
uniprot id: Q38C30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
messages: Belongs to the VPS51 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex.
messages: trans-Golgi network

185431:Tb927.7.2190
gene id: 185431:Tb927.7.2190
uniprot id: Q57XQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

185431:Tb927.6.5370
gene id: 185431:Tb927.6.5370
uniprot id: Q583L6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb09.211.3130
gene id: 185431:Tb09.211.3130
uniprot id: Q38DJ3
names: Function
names: Subunit
messages: Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase VP55 that creates mRNA's poly(A) tail. In the presence of VP39, VP55 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.
messages: Methyltransferase activity: Monomer, poly(A) polymerase activity: Heterodimer composed of a catalytic component, VP55, and a processivity factor, VP39. Interacts with Rap94 and NPH-I; these interactions might help linking transcription to capping and polyadenylation.

185431:Tb927.7.6110
gene id: 185431:Tb927.7.6110
uniprot id: Q57VK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

185431:Tb927.3.2960
gene id: 185431:Tb927.3.2960
uniprot id: Q57ZL6
names: Similarity
messages: Belongs to the IUNH family.

185431:Tb927.6.600
gene id: 185431:Tb927.6.600
uniprot id: Q583U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

185431:Tb927.7.3960
gene id: 185431:Tb927.7.3960
uniprot id: Q57UM6
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

185431:Tb927.6.1000
gene id: 185431:Tb927.6.1000
uniprot id: Q585E2
names: Similarity
messages: Belongs to the peptidase C1 family.

185431:Tb10.389.1330
gene id: 185431:Tb10.389.1330
uniprot id: Q389A3
names: Similarity
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.

185431:Tb09.160.3670
gene id: 185431:Tb09.160.3670
uniprot id: Q38F38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

185431:Tb10.70.0630
gene id: 185431:Tb10.70.0630
uniprot id: Q38AY7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

185431:Tb10.100.0080
gene id: 185431:Tb10.100.0080
uniprot id: Q38CL9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

185431:Tb927.7.1340
gene id: 185431:Tb927.7.1340
uniprot id: Q57WR6
names: Similarity
messages: Belongs to the GroES chaperonin family.

185431:Tb927.2.6230
gene id: 185431:Tb927.2.6230
uniprot id: Q586N0
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

185431:Tb10.61.0420
gene id: 185431:Tb10.61.0420
uniprot id: Q387S7
names: Subcellular Location Annotation
messages: Nucleus

185431:Tb927.3.2650
gene id: 185431:Tb927.3.2650
uniprot id: Q582X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

185431:Tb927.7.6620
gene id: 185431:Tb927.7.6620
uniprot id: Q57Y67
names: Subcellular Location Annotation
messages: Cytoplasm

185431:Tb927.7.6310
gene id: 185431:Tb927.7.6310
uniprot id: Q57VI0
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

185431:Tb10.406.0400
gene id: 185431:Tb10.406.0400
uniprot id: Q389T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.3.5050
gene id: 185431:Tb927.3.5050
uniprot id: Q582N2
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

185431:Tb927.4.3850
gene id: 185431:Tb927.4.3850
uniprot id: Q583H9
names: Subcellular Location Annotation
messages: nucleolus

185431:Tb927.2.5980
gene id: 185431:Tb927.2.5980
uniprot id: Q586B8
names: Similarity
messages: Belongs to the ClpA/ClpB family.

185431:Tb927.6.2050
gene id: 185431:Tb927.6.2050
uniprot id: Q584V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

185431:Tb927.3.2900
gene id: 185431:Tb927.3.2900
uniprot id: Q57ZM2
names: Similarity
messages: Belongs to the eIF-2-alpha family.

185431:Tb927.5.1930
gene id: 185431:Tb927.5.1930
uniprot id: Q57ZR2
names: Similarity
messages: Belongs to the SPCS3 family.

185431:Tb927.8.3310
gene id: 185431:Tb927.8.3310
uniprot id: Q57YY2
names: Similarity
messages: Belongs to the ELP3 family.

185431:Tb927.3.4850
gene id: 185431:Tb927.3.4850
uniprot id: Q582Q0
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

185431:Tb927.3.150
gene id: 185431:Tb927.3.150
uniprot id: Q57TS0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.70.0510
gene id: 185431:Tb10.70.0510
uniprot id: Q38AX4
names: Similarity
messages: Belongs to the CBF/MAK21 family.

185431:Tb10.05.0210
gene id: 185431:Tb10.05.0210
uniprot id: Q388P9
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.8.6460
gene id: 185431:Tb927.8.6460
uniprot id: Q57YP7
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

185431:Tb10.70.1230
gene id: 185431:Tb10.70.1230
uniprot id: Q38B29
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

185431:Tb927.4.5020
gene id: 185431:Tb927.4.5020
uniprot id: Q584K3
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

185431:Tb927.3.2850
gene id: 185431:Tb927.3.2850
uniprot id: Q57ZM7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

185431:Tb10.70.5030
gene id: 185431:Tb10.70.5030
uniprot id: Q38BY2
names: Similarity
messages: Belongs to the IST1 family.

185431:TB927.1.2570
gene id: 185431:TB927.1.2570
uniprot id: Q4GYW5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

185431:Tb10.70.1670
gene id: 185431:Tb10.70.1670
uniprot id: Q38B66
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

185431:Tb927.7.4140
gene id: 185431:Tb927.7.4140
uniprot id: Q57UP4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL21 family.

185431:Tb927.3.4640
gene id: 185431:Tb927.3.4640
uniprot id: Q582S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCC1 family.
messages: Membrane

185431:Tb927.4.5530
gene id: 185431:Tb927.4.5530
uniprot id: Q580P1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.7.4790
gene id: 185431:Tb927.7.4790
uniprot id: Q57X95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

185431:Tb09.211.0590
gene id: 185431:Tb09.211.0590
uniprot id: Q38E99
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

185431:Tb927.2.5240
gene id: 185431:Tb927.2.5240
uniprot id: Q585U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Nucleus
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.

185431:Tb927.8.7590
gene id: 185431:Tb927.8.7590
uniprot id: Q57V80
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb10.61.1210
gene id: 185431:Tb10.61.1210
uniprot id: Q4FKC0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

185431:Tb10.70.5830
gene id: 185431:Tb10.70.5830
uniprot id: Q38C43
names: Similarity
messages: Belongs to the actin family. ARP6 subfamily.

185431:Tb927.6.1350
gene id: 185431:Tb927.6.1350
uniprot id: Q585B2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.3.180
gene id: 185431:Tb927.3.180
uniprot id: Q57TR9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb09.160.3110
gene id: 185431:Tb09.160.3110
uniprot id: Q38F91
names: Similarity
messages: Belongs to the peptidase M16 family.

185431:TB927.1.2850
gene id: 185431:TB927.1.2850
uniprot id: Q4GYT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.
messages: Membrane

185431:Tb10.100.0060
gene id: 185431:Tb10.100.0060
uniprot id: Q38CM1
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

185431:Tb927.7.6130
gene id: 185431:Tb927.7.6130
uniprot id: Q57VJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

185431:Tb927.6.4520
gene id: 185431:Tb927.6.4520
uniprot id: Q587B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNS1 family.
messages: Nucleus

185431:Tb10.70.4860
gene id: 185431:Tb10.70.4860
uniprot id: Q38BW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

185431:Tb09.211.4870
gene id: 185431:Tb09.211.4870
uniprot id: Q38D23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: nucleolus

185431:Tb927.3.5490
gene id: 185431:Tb927.3.5490
uniprot id: Q580S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: cilium

185431:Tb927.6.2680
gene id: 185431:Tb927.6.2680
uniprot id: Q583R6
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.7.4930
gene id: 185431:Tb927.7.4930
uniprot id: Q57XA9
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

185431:Tb927.7.2130
gene id: 185431:Tb927.7.2130
uniprot id: Q57UZ8
names: Similarity
messages: Belongs to the DCC1 family.

185431:Tb927.8.3580
gene id: 185431:Tb927.8.3580
uniprot id: Q580X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

185431:Tb09.244.2580
gene id: 185431:Tb09.244.2580
uniprot id: Q38CW8
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.

185431:Tb927.8.4440
gene id: 185431:Tb927.8.4440
uniprot id: Q57VZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

185431:Tb10.6k15.2950
gene id: 185431:Tb10.6k15.2950
uniprot id: Q38AJ7
names: Similarity
messages: Belongs to the TMA16 family.

185431:Tb10.61.2680
gene id: 185431:Tb10.61.2680
uniprot id: Q388I8
names: Similarity
messages: Belongs to the pyruvate kinase family.

185431:Tb09.160.2540
gene id: 185431:Tb09.160.2540
uniprot id: Q38FD5
names: Similarity
messages: Belongs to the isochorismatase family.

185431:Tb09.211.3280
gene id: 185431:Tb09.211.3280
uniprot id: Q38DH8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

185431:Tb927.4.1080
gene id: 185431:Tb927.4.1080
uniprot id: Q580D6
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

185431:Tb927.7.1710
gene id: 185431:Tb927.7.1710
uniprot id: Q57V39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.
messages: Nucleus

185431:Tb10.61.1380
gene id: 185431:Tb10.61.1380
uniprot id: Q387Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

185431:Tb927.6.760
gene id: 185431:Tb927.6.760
uniprot id: Q583S7
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.4.4270
gene id: 185431:Tb927.4.4270
uniprot id: Q57Y31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb927.5.660
gene id: 185431:Tb927.5.660
uniprot id: Q57VF4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.100.0180
gene id: 185431:Tb10.100.0180
uniprot id: Q38CK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

185431:Tb10.70.3600
gene id: 185431:Tb10.70.3600
uniprot id: Q38BM3
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

185431:Tb927.8.920
gene id: 185431:Tb927.8.920
uniprot id: Q57YD9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

185431:Tb927.5.3510
gene id: 185431:Tb927.5.3510
uniprot id: Q57UB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Nucleus

185431:Tb927.4.480
gene id: 185431:Tb927.4.480
uniprot id: Q57US7
names: Function
messages: Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

185431:Tb10.61.3070
gene id: 185431:Tb10.61.3070
uniprot id: Q388L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

185431:Tb10.6k15.2020
gene id: 185431:Tb10.6k15.2020
uniprot id: Q38AB8
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

185431:Tb927.3.3230
gene id: 185431:Tb927.3.3230
uniprot id: Q57V63
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

185431:Tb09.211.4840
gene id: 185431:Tb09.211.4840
uniprot id: Q38D26
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

185431:Tb927.5.4260
gene id: 185431:Tb927.5.4260
uniprot id: Q57Z31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the histone H4 family.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.3.1840
gene id: 185431:Tb927.3.1840
uniprot id: Q57ZC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

185431:Tb09.211.2360
gene id: 185431:Tb09.211.2360
uniprot id: Q38DS1
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.5.2660
gene id: 185431:Tb927.5.2660
uniprot id: Q57ZU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

185431:Tb927.5.3820
gene id: 185431:Tb927.5.3820
uniprot id: Q57U84
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

185431:Tb10.70.5200
gene id: 185431:Tb10.70.5200
uniprot id: Q38BZ6
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.

185431:Tb09.160.2910
gene id: 185431:Tb09.160.2910
uniprot id: Q38FB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

185431:Tb10.70.7010
gene id: 185431:Tb10.70.7010
uniprot id: Q38CD0
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

185431:Tb927.4.4320
gene id: 185431:Tb927.4.4320
uniprot id: Q57Y36
names: Similarity
messages: Belongs to the CutA family.

185431:Tb10.389.0330
gene id: 185431:Tb10.389.0330
uniprot id: Q388T4
names: Similarity
messages: Belongs to the UDPGP type 1 family.

185431:Tb927.6.2640
gene id: 185431:Tb927.6.2640
uniprot id: Q583S0
names: Similarity
messages: Belongs to the importin alpha family.

185431:Tb10.70.6990
gene id: 185431:Tb10.70.6990
uniprot id: Q38CC9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb10.389.1060
gene id: 185431:Tb10.389.1060
uniprot id: Q388Y3
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

185431:Tb927.6.970
gene id: 185431:Tb927.6.970
uniprot id: Q585F0
names: Similarity
messages: Belongs to the peptidase C1 family.

185431:Tb10.70.0310
gene id: 185431:Tb10.70.0310
uniprot id: Q38AV7
names: Similarity
messages: Belongs to the CFAP97 family.

185431:Tb927.6.170
gene id: 185431:Tb927.6.170
uniprot id: Q57X00
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb10.61.2870
gene id: 185431:Tb10.61.2870
uniprot id: Q388J8
names: Similarity
messages: Belongs to the CEP43 family.
messages: Belongs to the TBCC family.

185431:Tb927.8.1130
gene id: 185431:Tb927.8.1130
uniprot id: Q57VP1
names: Similarity
messages: Belongs to the PPP phosphatase family.

185431:Tb927.8.2500
gene id: 185431:Tb927.8.2500
uniprot id: Q57XD9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.

185431:Tb09.244.2720
gene id: 185431:Tb09.244.2720
uniprot id: Q38CY7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

185431:Tb927.4.3160
gene id: 185431:Tb927.4.3160
uniprot id: Q583Z3
names: Similarity
messages: Belongs to the GPAT/DAPAT family.

185431:TB927.1.3030
gene id: 185431:TB927.1.3030
uniprot id: P86925
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA ligase 2 family.
messages: Component of the RNA editing complex, a 1600 kDa complex composed of at least 20 proteins.
messages: Mitochondrion
messages: RNA editing in kinetoplastid mitochondria inserts and deletes uridylates at multiple sites in pre-mRNAs as directed by guide RNAs.

185431:Tb09.142.0450
gene id: 185431:Tb09.142.0450
uniprot id: Q38G28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb09.244.2380
gene id: 185431:Tb09.244.2380
uniprot id: Q38CU7
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.7.6540
gene id: 185431:Tb927.7.6540
uniprot id: Q57Y75
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.5.840
gene id: 185431:Tb927.5.840
uniprot id: Q57W29
names: Similarity
messages: Belongs to the KRI1 family.

185431:Tb10.6k15.3670
gene id: 185431:Tb10.6k15.3670
uniprot id: Q38AQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: nuclear pore complex

185431:Tb927.7.7060
gene id: 185431:Tb927.7.7060
uniprot id: Q57XS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

185431:TB927.1.2120
gene id: 185431:TB927.1.2120
uniprot id: Q4GZ09
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb927.2.4090
gene id: 185431:Tb927.2.4090
uniprot id: Q586V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

185431:Tb09.211.1870
gene id: 185431:Tb09.211.1870
uniprot id: Q38DW7
names: Similarity
messages: Belongs to the PIH1 family.

185431:Tb927.7.6050
gene id: 185431:Tb927.7.6050
uniprot id: Q57VK6
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb09.211.1960
gene id: 185431:Tb09.211.1960
uniprot id: Q38DV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

185431:Tb927.4.4410
gene id: 185431:Tb927.4.4410
uniprot id: D6XEJ9
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.8.3420
gene id: 185431:Tb927.8.3420
uniprot id: Q57YX1
names: Similarity
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.

185431:Tb09.160.2550
gene id: 185431:Tb09.160.2550
uniprot id: Q38FD9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.

185431:Tb927.4.5370
gene id: 185431:Tb927.4.5370
uniprot id: Q580Q0
names: Similarity
messages: Belongs to the GAMAD family.

185431:Tb09.211.3270
gene id: 185431:Tb09.211.3270
uniprot id: Q38DH8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

185431:Tb10.61.0440
gene id: 185431:Tb10.61.0440
uniprot id: Q387S9
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.

185431:Tb927.5.1280
gene id: 185431:Tb927.5.1280
uniprot id: Q57VD5
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

185431:Tb927.5.910
gene id: 185431:Tb927.5.910
uniprot id: Q57W36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

185431:Tb927.2.3480
gene id: 185431:Tb927.2.3480
uniprot id: Q586Y0
names: Subcellular Location Annotation
messages: Nucleus

185431:Tb927.3.3400
gene id: 185431:Tb927.3.3400
uniprot id: Q57V46
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.4.3570
gene id: 185431:Tb927.4.3570
uniprot id: Q585J3
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

185431:Tb927.8.6060
gene id: 185431:Tb927.8.6060
uniprot id: Q57YK7
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

185431:Tb927.4.3940
gene id: 185431:Tb927.4.3940
uniprot id: Q57XZ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb927.7.240
gene id: 185431:Tb927.7.240
uniprot id: Q57U30
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

185431:Tb927.5.4380
gene id: 185431:Tb927.5.4380
uniprot id: Q57Z11
names: Similarity
messages: Belongs to the PPP phosphatase family.

185431:Tb09.160.3470
gene id: 185431:Tb09.160.3470
uniprot id: Q38F58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome
messages: Nucleus

185431:Tb927.8.6320
gene id: 185431:Tb927.8.6320
uniprot id: Q57YN3
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

185431:Tb09.160.3590
gene id: 185431:Tb09.160.3590
uniprot id: Q38F46
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

185431:Tb927.7.3260
gene id: 185431:Tb927.7.3260
uniprot id: Q57YD6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

185431:Tb927.3.1450
gene id: 185431:Tb927.3.1450
uniprot id: Q57XX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

185431:Tb10.70.2760
gene id: 185431:Tb10.70.2760
uniprot id: Q38BF5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

185431:Tb927.4.590
gene id: 185431:Tb927.4.590
uniprot id: Q57ZY7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

185431:Tb927.4.3710
gene id: 185431:Tb927.4.3710
uniprot id: Q585H9
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.4.800
gene id: 185431:Tb927.4.800
uniprot id: Q580A8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

185431:Tb927.7.5930
gene id: 185431:Tb927.7.5930
uniprot id: Q582K8
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.05.0150
gene id: 185431:Tb10.05.0150
uniprot id: Q388Q5
names: Similarity
messages: Belongs to the citrate synthase family.

185431:Tb927.3.3100
gene id: 185431:Tb927.3.3100
uniprot id: Q57ZK2
names: Similarity
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.

185431:Tb09.142.0240
gene id: 185431:Tb09.142.0240
uniprot id: Q38G41
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.4.5400
gene id: 185431:Tb927.4.5400
uniprot id: Q580P7
names: Function
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.6.4980
gene id: 185431:Tb927.6.4980
uniprot id: Q4FKG9
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

185431:Tb927.8.3530
gene id: 185431:Tb927.8.3530
uniprot id: Q57YW0
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

185431:Tb927.6.3250
gene id: 185431:Tb927.6.3250
uniprot id: Q584W8
names: Similarity
messages: Belongs to the ZNF277 family.

185431:Tb927.7.3340
gene id: 185431:Tb927.7.3340
uniprot id: Q57WE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

185431:Tb927.5.1110
gene id: 185431:Tb927.5.1110
uniprot id: Q57W56
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

185431:Tb09.211.2630
gene id: 185431:Tb09.211.2630
uniprot id: Q38DP2
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

185431:Tb927.4.1130
gene id: 185431:Tb927.4.1130
uniprot id: Q580E1
names: Similarity
messages: Belongs to the complex I LYR family.

185431:Tb927.6.220
gene id: 185431:Tb927.6.220
uniprot id: Q581D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

185431:Tb927.7.3220
gene id: 185431:Tb927.7.3220
uniprot id: Q57YD2
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

185431:Tb927.7.2930
gene id: 185431:Tb927.7.2930
uniprot id: Q57YA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb09.211.3640
gene id: 185431:Tb09.211.3640
uniprot id: Q38DE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

185431:Tb927.7.4340
gene id: 185431:Tb927.7.4340
uniprot id: Q57UR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

185431:Tb927.7.1120
gene id: 185431:Tb927.7.1120
uniprot id: D6XK30
names: Similarity
messages: Belongs to the glutathione peroxidase family.

185431:Tb10.6k15.1240
gene id: 185431:Tb10.6k15.1240
uniprot id: Q38A56
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.7.5180
gene id: 185431:Tb927.7.5180
uniprot id: Q57ZH1
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

185431:Tb10.70.4380
gene id: 185431:Tb10.70.4380
uniprot id: Q38BT4
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

185431:Tb10.6k15.2780
gene id: 185431:Tb10.6k15.2780
uniprot id: Q38AI5
names: Similarity
messages: Belongs to the UFD1 family.

185431:Tb10.389.1210
gene id: 185431:Tb10.389.1210
uniprot id: Q388Z4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb09.160.0710
gene id: 185431:Tb09.160.0710
uniprot id: Q38FW8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

185431:Tb927.6.2840
gene id: 185431:Tb927.6.2840
uniprot id: Q583Q0
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

185431:Tb927.8.6840
gene id: 185431:Tb927.8.6840
uniprot id: Q57TS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

185431:Tb927.2.4590
gene id: 185431:Tb927.2.4590
uniprot id: Q586R0
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

185431:Tb927.6.3510
gene id: 185431:Tb927.6.3510
uniprot id: Q584Z1
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

185431:Tb10.70.2660
gene id: 185431:Tb10.70.2660
uniprot id: Q38BE4
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

185431:Tb09.211.4511
gene id: 185431:Tb09.211.4511
uniprot id: Q38D58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KMP-11 family.
messages: Monomer.
messages: cytoskeleton

185431:Tb09.160.4850
gene id: 185431:Tb09.160.4850
uniprot id: Q38ES2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

185431:Tb927.3.5400
gene id: 185431:Tb927.3.5400
uniprot id: Q580T5
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

185431:Tb927.5.1230
gene id: 185431:Tb927.5.1230
uniprot id: Q57VE0
names: Similarity
messages: Belongs to the CFAP53 family.

185431:Tb927.6.2880
gene id: 185431:Tb927.6.2880
uniprot id: Q583P6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.6.1820
gene id: 185431:Tb927.6.1820
uniprot id: Q585M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

185431:Tb927.5.320
gene id: 185431:Tb927.5.320
uniprot id: Q57VY1
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb09.160.4150
gene id: 185431:Tb09.160.4150
uniprot id: Q38EZ0
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
messages: E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

185431:Tb927.8.1160
gene id: 185431:Tb927.8.1160
uniprot id: Q57VN8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

185431:Tb927.4.5260
gene id: 185431:Tb927.4.5260
uniprot id: Q584H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb927.4.420
gene id: 185431:Tb927.4.420
uniprot id: Q57UT3
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

185431:Tb927.3.2170
gene id: 185431:Tb927.3.2170
uniprot id: Q582T0
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

185431:Tb927.6.1680
gene id: 185431:Tb927.6.1680
uniprot id: Q585P3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the REH2-associated complex (REH2C) composed of helicase REH2, associated factors H2F1 and H2F2, and mRNAs at various editing stages; the formation of the complex is RNA-independent (PubMed:26769962, PubMed:31034523). Within the complex, interacts with REH2; the interaction is direct (PubMed:26769962). Interacts with various editing complexes including the RNA editing core (RECC) complex, the gRNA-binding (GRBC) complex (also known as the MRB1 complex) and the RNA editing mediator (REMC) complex (PubMed:26769962, PubMed:31034523).
messages: Expressed at the procyclic stage (at protein level).
messages: Mitochondrion
messages: Plays an important role in mitochondrial mRNA editing by promoting the assembly of the mRNA editosome (PubMed:26769962, PubMed:31034523). Facilitates the recruitment of mRNA to the REH2C complex and promotes the interaction between various editing complexes including REH2C, GRBC, REMC and RECC complexes (PubMed:26769962, PubMed:31034523).
messages: RNAi-mediated knockdown at the procyclic stage causes a reduction in mitochondrial mRNA editing (PubMed:26769962). Formation of the REH2C complex is not affected but REH2C complex association with the GRBC, REMC, RECC complexes and with and pre-mRNA is impaired (PubMed:26769962). Integrity of the GRBC complex is not affected but GRBC complex association with the RECC complex and pre-mRNA is reduced (PubMed:26769962). Causes a slight decrease in REH2 protein levels (PubMed:26769962, PubMed:31034523). Does not affect the RNA unwinding activity of the REH2C complex (PubMed:26769962).

185431:Tb09.211.0100
gene id: 185431:Tb09.211.0100
uniprot id: Q38EF1
names: Similarity
messages: Belongs to the WASH1 family.

185431:Tb927.6.1650
gene id: 185431:Tb927.6.1650
uniprot id: Q585P5
names: Similarity
messages: Belongs to the nuclease type I family.

185431:Tb10.70.5260
gene id: 185431:Tb10.70.5260
uniprot id: Q38C02
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb09.160.5670
gene id: 185431:Tb09.160.5670
uniprot id: Q38EI1
names: Similarity
messages: Belongs to the TTC21 family.

185431:Tb927.4.980
gene id: 185431:Tb927.4.980
uniprot id: Q580C6
names: Similarity
messages: Belongs to the actin family.

185431:Tb927.3.3000
gene id: 185431:Tb927.3.3000
uniprot id: Q57ZL2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IFT56 family.
messages: Component of the IFT complex B.
messages: Component of the intraflagellar transport (IFT) complex required for transport of proteins in the motile cilium.
messages: Defects in new flagellum formation.
messages: flagellum

185431:Tb927.4.5240
gene id: 185431:Tb927.4.5240
uniprot id: Q584I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb927.8.3730
gene id: 185431:Tb927.8.3730
uniprot id: Q580Z3
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.7.4330
gene id: 185431:Tb927.7.4330
uniprot id: Q57UR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: centriole
messages: cilium basal body

185431:Tb10.70.5150
gene id: 185431:Tb10.70.5150
uniprot id: Q38BZ2
names: Similarity
messages: Belongs to the adenylate kinase family.

185431:Tb10.389.1180
gene id: 185431:Tb10.389.1180
uniprot id: Q388Z3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb927.3.2500
gene id: 185431:Tb927.3.2500
uniprot id: Q582W3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.389.0490
gene id: 185431:Tb10.389.0490
uniprot id: Q388U5
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.2.2430
gene id: 185431:Tb927.2.2430
uniprot id: Q586L5
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.8.6210
gene id: 185431:Tb927.8.6210
uniprot id: Q57YM2
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

185431:Tb927.8.7150
gene id: 185431:Tb927.8.7150
uniprot id: Q57YS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb10.05.0080
gene id: 185431:Tb10.05.0080
uniprot id: Q388N5
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

185431:Tb10.389.0270
gene id: 185431:Tb10.389.0270
uniprot id: Q388S8
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.

185431:Tb927.6.4390
gene id: 185431:Tb927.6.4390
uniprot id: Q587A5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.6.1050
gene id: 185431:Tb927.6.1050
uniprot id: Q585E2
names: Similarity
messages: Belongs to the peptidase C1 family.

185431:Tb09.v1.0320
gene id: 185431:Tb09.v1.0320
uniprot id: Q38EK6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.3.860
gene id: 185431:Tb927.3.860
uniprot id: Q57WW9
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

185431:Tb927.7.1720
gene id: 185431:Tb927.7.1720
uniprot id: Q57V38
names: Similarity
messages: Belongs to the NifU family.

185431:Tb09.160.3540
gene id: 185431:Tb09.160.3540
uniprot id: Q38F51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS1/PSF1 family.
messages: Nucleus

185431:Tb927.4.1350
gene id: 185431:Tb927.4.1350
uniprot id: Q581U6
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

185431:Tb927.3.4490
gene id: 185431:Tb927.3.4490
uniprot id: Q580J3
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

185431:Tb927.7.1680
gene id: 185431:Tb927.7.1680
uniprot id: Q57V42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

185431:TB927.1.1980
gene id: 185431:TB927.1.1980
uniprot id: Q4GZ21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

185431:Tb927.8.1610
gene id: 185431:Tb927.8.1610
uniprot id: Q580G2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

185431:Tb927.3.3950
gene id: 185431:Tb927.3.3950
uniprot id: Q57WD1
names: Similarity
messages: Belongs to the LTV1 family.

185431:Tb927.5.2950
gene id: 185431:Tb927.5.2950
uniprot id: Q57ZX1
names: Subcellular Location Annotation
messages: cilium axoneme

185431:Tb927.4.2000
gene id: 185431:Tb927.4.2000
uniprot id: Q583J3
names: Similarity
messages: Belongs to the RuvB family.

185431:Tb10.6k15.3350
gene id: 185431:Tb10.6k15.3350
uniprot id: Q38AM9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

185431:Tb927.7.5490
gene id: 185431:Tb927.7.5490
uniprot id: Q582G4
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Arginine methyltransferase that specifically catalyzes the formation of omega-N monomethylarginine (MMA). Has activity toward multiple substrates in vitro. Able to mediate the arginine methylation of histones and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
messages: Compared to PRMT7 orthologs in other metazoans, it is shorter and lacks the C-terminal part.
messages: Cytoplasm
messages: Expressed during both bloodstream (BF) and procyclic insect (PF) life cycle stages.
messages: Present in large multiprotein complexes.

185431:TB927.1.3850
gene id: 185431:TB927.1.3850
uniprot id: Q4GYJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Membrane

185431:TB927.1.710
gene id: 185431:TB927.1.710
uniprot id: Q4GZG3
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

185431:Tb10.406.0320
gene id: 185431:Tb10.406.0320
uniprot id: Q389R8
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

185431:Tb10.70.1380
gene id: 185431:Tb10.70.1380
uniprot id: Q57VP3
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

185431:Tb927.8.5720
gene id: 185431:Tb927.8.5720
uniprot id: Q57X10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

185431:Tb927.4.4650
gene id: 185431:Tb927.4.4650
uniprot id: Q583F0
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

185431:Tb927.4.1850
gene id: 185431:Tb927.4.1850
uniprot id: D6XFC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Cytoplasm
messages: nucleolus

185431:Tb927.4.5420
gene id: 185431:Tb927.4.5420
uniprot id: Q580P5
names: Function
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.6k15.3320
gene id: 185431:Tb10.6k15.3320
uniprot id: Q38AM7
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.70.2940
gene id: 185431:Tb10.70.2940
uniprot id: Q38BH0
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.4.3080
gene id: 185431:Tb927.4.3080
uniprot id: Q583Y5
names: Similarity
messages: Belongs to the UPF0235 family.

185431:Tb10.70.5940
gene id: 185431:Tb10.70.5940
uniprot id: Q38C52
names: Similarity
messages: Belongs to the type IA topoisomerase family.

185431:Tb10.70.4390
gene id: 185431:Tb10.70.4390
uniprot id: Q38BT5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.

185431:Tb10.6k15.2290
gene id: 185431:Tb10.6k15.2290
uniprot id: Q38AE1
names: Similarity
messages: Belongs to the protein disulfide isomerase family.

185431:Tb927.4.470
gene id: 185431:Tb927.4.470
uniprot id: Q57US8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

185431:Tb927.4.1440
gene id: 185431:Tb927.4.1440
uniprot id: Q581T7
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

185431:Tb927.3.5610
gene id: 185431:Tb927.3.5610
uniprot id: Q580R4
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

185431:Tb927.5.230
gene id: 185431:Tb927.5.230
uniprot id: Q57XH3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.2.6410
gene id: 185431:Tb927.2.6410
uniprot id: Q586M4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.6k15.1000
gene id: 185431:Tb10.6k15.1000
uniprot id: Q38A35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

185431:Tb10.61.0910
gene id: 185431:Tb10.61.0910
uniprot id: Q387W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

185431:Tb927.3.1750
gene id: 185431:Tb927.3.1750
uniprot id: Q57ZD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAD2 family.
messages: Nucleus

185431:Tb927.6.780
gene id: 185431:Tb927.6.780
uniprot id: Q583S5
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb09.211.2440
gene id: 185431:Tb09.211.2440
uniprot id: Q38DR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Membrane

185431:Tb09.160.3880
gene id: 185431:Tb09.160.3880
uniprot id: Q38F18
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

185431:TB927.1.720
gene id: 185431:TB927.1.720
uniprot id: Q4GZE6
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

185431:Tb10.70.1880
gene id: 185431:Tb10.70.1880
uniprot id: Q38B80
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

185431:Tb927.8.3510
gene id: 185431:Tb927.8.3510
uniprot id: Q57YW2
names: Similarity
messages: Belongs to the thymidylate kinase family.

185431:Tb927.7.1140
gene id: 185431:Tb927.7.1140
uniprot id: D6XK32
names: Similarity
messages: Belongs to the glutathione peroxidase family.

185431:Tb10.6k15.0270
gene id: 185431:Tb10.6k15.0270
uniprot id: Q389X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

185431:Tb10.70.5380
gene id: 185431:Tb10.70.5380
uniprot id: Q38C09
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

185431:Tb10.389.0670
gene id: 185431:Tb10.389.0670
uniprot id: Q388W0
names: Similarity
messages: Belongs to the PIH1 family.

185431:Tb927.6.1170
gene id: 185431:Tb927.6.1170
uniprot id: Q585D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APH-1 family.
messages: Membrane

185431:Tb09.160.3210
gene id: 185431:Tb09.160.3210
uniprot id: Q38F81
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

185431:Tb09.211.1330
gene id: 185431:Tb09.211.1330
uniprot id: Q38E22
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.70.5820
gene id: 185431:Tb10.70.5820
uniprot id: Q38C42
names: Similarity
messages: Belongs to the hexokinase family.

185431:Tb927.3.3330
gene id: 185431:Tb927.3.3330
uniprot id: Q57V53
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

185431:Tb927.5.3680
gene id: 185431:Tb927.5.3680
uniprot id: Q57U98
names: Similarity
messages: Belongs to the PIGH family.

185431:Tb927.4.5310
gene id: 185431:Tb927.4.5310
uniprot id: Q580Q4
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.3.3390
gene id: 185431:Tb927.3.3390
uniprot id: Q57V47
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.7.3760
gene id: 185431:Tb927.7.3760
uniprot id: Q57WJ1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

185431:Tb927.8.1920
gene id: 185431:Tb927.8.1920
uniprot id: Q581Z0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus

185431:Tb927.4.3860
gene id: 185431:Tb927.4.3860
uniprot id: Q583I0
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb10.61.0340
gene id: 185431:Tb10.61.0340
uniprot id: Q387S0
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.6.540
gene id: 185431:Tb927.6.540
uniprot id: Q581G2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb09.160.0780
gene id: 185431:Tb09.160.0780
uniprot id: Q38FW1
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

185431:Tb927.6.2270
gene id: 185431:Tb927.6.2270
uniprot id: Q584S3
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

185431:Tb927.3.1140
gene id: 185431:Tb927.3.1140
uniprot id: Q57WZ5
names: Subcellular Location Annotation
messages: Nucleus

185431:TB927.1.880
gene id: 185431:TB927.1.880
uniprot id: Q4GZD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the midasin family.
messages: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.
messages: nucleolus
messages: nucleoplasm

185431:Tb927.7.3900
gene id: 185431:Tb927.7.3900
uniprot id: Q57UM0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the vacuolar transporter chaperone (VTC) complex. The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP. VTC exposes its catalytic domain vtc4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation. The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen. PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase. VTC1 contributes only 3 transmembrane domains to the complex. The VTC complex also plays a role in vacuolar membrane fusion.
messages: Acidocalcisome membrane
messages: Belongs to the VTC1 family.
messages: Causes an abnormal morphology of acidocalcisomes, a significant decrease in the amount of polyP and a deficient response to hyposmotic stress.
messages: The VTC core complex is an integral membrane heterooligomer composed of at least the catalytic subunit vtc4 and the accessory subunits vtc1 and vtc2. vtc1 is a small membrane protein without hydrophilic domain. Vtc2 and vtc4 are related and have 2 hydrophilic domains that face the cytosol, an N-terminal SPX domain and the central core domain. The central core in vtc4 is the catalytic domain.

185431:Tb927.3.5550
gene id: 185431:Tb927.3.5550
uniprot id: Q580S0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Component of the IFT complex B.
messages: Expressed during procyclic stages.
messages: Small GTPase-like component of the intraflagellar transport (IFT) complex B required for both anterograde and retrograde intraflagellar transport. May be involved in cargo loading of the retrograde transport.
messages: flagellum

185431:Tb10.389.1150
gene id: 185431:Tb10.389.1150
uniprot id: Q388Z0
names: Similarity
messages: Belongs to the DPH4 family.

185431:Tb09.211.0860
gene id: 185431:Tb09.211.0860
uniprot id: Q38E70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

185431:Tb927.8.6500
gene id: 185431:Tb927.8.6500
uniprot id: Q57TW3
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

185431:Tb10.389.0160
gene id: 185431:Tb10.389.0160
uniprot id: Q388S0
names: Similarity
messages: Belongs to the WD repeat PWP2 family.

185431:TB927.1.870
gene id: 185431:TB927.1.870
uniprot id: Q4GZD1
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the deoxyhypusine synthase family.
messages: Heterotetramer formed by a homodimer of the non-catalytic regulatory subunit DHSp and a homodimer of the catalytic subunit DHSc where DHSc appears to bind spermidine and DHSp appears to bind NAD(+).
messages: Lacks the conserved active site Lys, and therefore lacks catalytic activity.
messages: RNAi-mediated knockdown causes cell growth arrest followed by death, loss of DHSp expression and a failure to sustain infection in mice.
messages: Required for the activation and stability of deoxyhypusine synthase DHSc. Required for cell growth and survival.

185431:Tb927.8.5600
gene id: 185431:Tb927.8.5600
uniprot id: Q57X22
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

185431:Tb927.8.2450
gene id: 185431:Tb927.8.2450
uniprot id: Q57XE4
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.

185431:Tb927.7.2760
gene id: 185431:Tb927.7.2760
uniprot id: Q57Y86
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

185431:Tb927.4.4070
gene id: 185431:Tb927.4.4070
uniprot id: Q57Y11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Cytoplasm

185431:Tb927.6.720
gene id: 185431:Tb927.6.720
uniprot id: Q583T1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

185431:Tb10.70.7330
gene id: 185431:Tb10.70.7330
uniprot id: Q38CF7
names: Similarity
messages: Belongs to the adenylate kinase family.

185431:Tb927.8.2870
gene id: 185431:Tb927.8.2870
uniprot id: Q57W85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP162 family.
messages: centriole

185431:Tb927.8.5040
gene id: 185431:Tb927.8.5040
uniprot id: Q57UH6
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

185431:Tb927.6.2440
gene id: 185431:Tb927.6.2440
uniprot id: Q584R2
names: Similarity
messages: Belongs to the Mo25 family.

185431:Tb927.4.1780
gene id: 185431:Tb927.4.1780
uniprot id: Q581Q3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb10.61.0770
gene id: 185431:Tb10.61.0770
uniprot id: Q387V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

185431:Tb927.5.1000
gene id: 185431:Tb927.5.1000
uniprot id: Q57W45
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

185431:Tb927.8.5140
gene id: 185431:Tb927.8.5140
uniprot id: Q57UI6
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

185431:Tb927.8.3470
gene id: 185431:Tb927.8.3470
uniprot id: Q57YW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

185431:Tb10.70.7090
gene id: 185431:Tb10.70.7090
uniprot id: Q38CD6
names: Similarity
messages: Belongs to the peptidase S10 family.

185431:Tb927.5.2750
gene id: 185431:Tb927.5.2750
uniprot id: Q57ZV1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

185431:TB927.1.1000
gene id: 185431:TB927.1.1000
uniprot id: Q4GZB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

185431:Tb927.3.2320
gene id: 185431:Tb927.3.2320
uniprot id: Q582U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN2 family.
messages: Cytoplasm
messages: Nucleus

185431:TB927.1.2470
gene id: 185431:TB927.1.2470
uniprot id: Q4GYX7
names: Similarity
messages: Belongs to the histone H3 family.

185431:Tb927.2.5060
gene id: 185431:Tb927.2.5060
uniprot id: Q586U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.

185431:Tb10.6k15.3990
gene id: 185431:Tb10.6k15.3990
uniprot id: Q38AS9
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

185431:Tb10.70.1440
gene id: 185431:Tb10.70.1440
uniprot id: P86936
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family. PIGB subfamily.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).
messages: The protozoan parasite evades the immune response of mammalian hosts and digestion in the gut of the insect vector by means of its coat proteins tethered to the cell surface via GPI-anchors. GPI10 is essential for growth of mammalian stage bloodstream form, while procyclic form (insect stage parasites) are viable but grow slower, suggesting that inhibition of GPI synthesis may be an effective chemotherapy against African trypanosomiasis (By similarity).

185431:Tb927.5.2980
gene id: 185431:Tb927.5.2980
uniprot id: Q57ZX4
names: Similarity
messages: Belongs to the SEC3 family.

185431:Tb927.6.3940
gene id: 185431:Tb927.6.3940
uniprot id: Q585Z2
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.3.4900
gene id: 185431:Tb927.3.4900
uniprot id: Q582P5
names: Similarity
messages: Belongs to the IPP transferase family.

185431:Tb09.244.2020
gene id: 185431:Tb09.244.2020
uniprot id: Q38CR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

185431:Tb927.8.870
gene id: 185431:Tb927.8.870
uniprot id: Q57YE4
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb09.244.1740
gene id: 185431:Tb09.244.1740
uniprot id: Q38CQ7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.389.1310
gene id: 185431:Tb10.389.1310
uniprot id: Q389A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb10.70.3710
gene id: 185431:Tb10.70.3710
uniprot id: Q38BN3
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

185431:Tb927.8.7940
gene id: 185431:Tb927.8.7940
uniprot id: Q57U51
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.8.1200
gene id: 185431:Tb927.8.1200
uniprot id: D6XMU9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

185431:Tb927.7.7260
gene id: 185431:Tb927.7.7260
uniprot id: Q57XU6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb10.70.1200
gene id: 185431:Tb10.70.1200
uniprot id: Q38B28
names: Similarity
messages: Belongs to the adenylate kinase family.

185431:Tb927.4.3630
gene id: 185431:Tb927.4.3630
uniprot id: Q585I7
names: Similarity
messages: Belongs to the PPP phosphatase family.

185431:Tb927.8.4290
gene id: 185431:Tb927.8.4290
uniprot id: Q57W06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

185431:Tb927.8.3550
gene id: 185431:Tb927.8.3550
uniprot id: Q580X5
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

185431:Tb10.70.0170
gene id: 185431:Tb10.70.0170
uniprot id: Q38AU5
names: Subcellular Location Annotation
messages: Membrane

185431:Tb09.160.2990
gene id: 185431:Tb09.160.2990
uniprot id: Q38FA2
names: Similarity
messages: Belongs to the DDI1 family.

185431:Tb927.3.4650
gene id: 185431:Tb927.3.4650
uniprot id: Q582S0
names: Similarity
messages: Belongs to the ERG2 family.

185431:TB927.1.2390
gene id: 185431:TB927.1.2390
uniprot id: Q4GYY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

185431:Tb927.3.3160
gene id: 185431:Tb927.3.3160
uniprot id: Q57ZJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

185431:Tb927.4.3770
gene id: 185431:Tb927.4.3770
uniprot id: Q583H1
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb09.211.3040
gene id: 185431:Tb09.211.3040
uniprot id: Q38DK1
names: Similarity
messages: Belongs to the XPC family.

185431:Tb927.2.4020
gene id: 185431:Tb927.2.4020
uniprot id: Q586W2
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.

185431:Tb10.6k15.2620
gene id: 185431:Tb10.6k15.2620
uniprot id: Q38AH1
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.

185431:Tb10.70.0280
gene id: 185431:Tb10.70.0280
uniprot id: Q38AV5
names: Function
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.
messages: Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.

185431:Tb927.2.6080
gene id: 185431:Tb927.2.6080
uniprot id: D7SG80
names: Subcellular Location Annotation
messages: Cytoplasm

185431:Tb10.61.2100
gene id: 185431:Tb10.61.2100
uniprot id: Q388E6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb09.211.4360
gene id: 185431:Tb09.211.4360
uniprot id: Q38D75
names: Subcellular Location Annotation
messages: Cytoplasm

185431:Tb09.160.4310
gene id: 185431:Tb09.160.4310
uniprot id: Q38EX6
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.

185431:Tb927.8.3660
gene id: 185431:Tb927.8.3660
uniprot id: Q580Y6
names: Similarity
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.

185431:Tb927.2.2160
gene id: 185431:Tb927.2.2160
uniprot id: Q586J7
names: Similarity
messages: Belongs to the SNAP family.

185431:Tb927.4.4740
gene id: 185431:Tb927.4.4740
uniprot id: Q583F9
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.7.3320
gene id: 185431:Tb927.7.3320
uniprot id: Q57WE7
names: Similarity
messages: Belongs to the ATG8 family.

185431:Tb927.6.2170
gene id: 185431:Tb927.6.2170
uniprot id: Q584T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

185431:Tb927.7.5790
gene id: 185431:Tb927.7.5790
uniprot id: Q582J4
names: Similarity
messages: Belongs to the protein disulfide isomerase family.

185431:Tb10.6k15.0020
gene id: 185431:Tb10.6k15.0020
uniprot id: Q389V1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Major surface antigen of procyclic forms.
messages: Membrane

185431:Tb10.61.0260
gene id: 185431:Tb10.61.0260
uniprot id: Q387R3
names: Similarity
messages: Belongs to the PIH1 family.

185431:Tb927.7.6060
gene id: 185431:Tb927.7.6060
uniprot id: Q57VK5
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb10.v4.0024
gene id: 185431:Tb10.v4.0024
uniprot id: Q387P2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.7.5980
gene id: 185431:Tb927.7.5980
uniprot id: Q57VL3
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.7.7430
gene id: 185431:Tb927.7.7430
uniprot id: Q57TX9
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

185431:Tb927.5.4810
gene id: 185431:Tb927.5.4810
uniprot id: Q57X37
names: Function
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb09.160.4240
gene id: 185431:Tb09.160.4240
uniprot id: Q38EY2
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

185431:Tb10.6k15.1180
gene id: 185431:Tb10.6k15.1180
uniprot id: Q38A51
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

185431:Tb10.70.0540
gene id: 185431:Tb10.70.0540
uniprot id: Q38AX7
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.

185431:Tb10.6k15.2610
gene id: 185431:Tb10.6k15.2610
uniprot id: Q38AH0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a complex composed of CBF5, GAR1, NHP2, MTR1, NOP10 and Tb11.01.8210.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of spliced leader and U1 small nuclear RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped RNA to produce m(7)GpppNmp (cap1). Cap1 modification is linked to higher levels of translation. Recognizes a guanosine cap on RNA independent of its N(7) methylation status.

185431:Tb10.6k15.1750
gene id: 185431:Tb10.6k15.1750
uniprot id: Q38A95
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.

185431:Tb10.61.1040
gene id: 185431:Tb10.61.1040
uniprot id: Q387X6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

185431:Tb09.211.3730
gene id: 185431:Tb09.211.3730
uniprot id: Q38DD6
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.

185431:Tb927.8.8350
gene id: 185431:Tb927.8.8350
uniprot id: Q57WJ5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.7.5960
gene id: 185431:Tb927.7.5960
uniprot id: Q57VL5
names: Subcellular Location Annotation
messages: Membrane

185431:Tb09.211.0050
gene id: 185431:Tb09.211.0050
uniprot id: Q38EF6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

185431:Tb927.2.1800
gene id: 185431:Tb927.2.1800
uniprot id: Q585S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

185431:Tb10.61.0250
gene id: 185431:Tb10.61.0250
uniprot id: Q387R2
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

185431:Tb927.5.3710
gene id: 185431:Tb927.5.3710
uniprot id: Q57U95
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

185431:Tb927.5.4500
gene id: 185431:Tb927.5.4500
uniprot id: Q57X54
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

185431:Tb09.211.3850
gene id: 185431:Tb09.211.3850
uniprot id: Q38DC4
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

185431:TB927.1.570
gene id: 185431:TB927.1.570
uniprot id: Q4GZF2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus

185431:Tb10.100.0170
gene id: 185431:Tb10.100.0170
uniprot id: Q38CK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.

185431:Tb10.70.0120
gene id: 185431:Tb10.70.0120
uniprot id: Q38AU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

185431:Tb927.8.5470
gene id: 185431:Tb927.8.5470
uniprot id: Q57X35
names: Function
names: Similarity
messages: Belongs to the calflagin family.
messages: May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form.

185431:Tb927.6.4840
gene id: 185431:Tb927.6.4840
uniprot id: Q586G3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

185431:Tb10.6k15.2410
gene id: 185431:Tb10.6k15.2410
uniprot id: Q38AF3
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.6.2100
gene id: 185431:Tb927.6.2100
uniprot id: Q584U6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS30 family.

185431:Tb10.61.2530
gene id: 185431:Tb10.61.2530
uniprot id: Q388H6
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

185431:Tb10.6k15.2840
gene id: 185431:Tb10.6k15.2840
uniprot id: Q38AJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane

185431:Tb927.8.7170
gene id: 185431:Tb927.8.7170
uniprot id: Q57YS3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

185431:Tb927.7.2750
gene id: 185431:Tb927.7.2750
uniprot id: Q57Y85
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.7.1580
gene id: 185431:Tb927.7.1580
uniprot id: Q57WP2
names: Similarity
messages: Belongs to the VPS52 family.

185431:Tb927.6.5110
gene id: 185431:Tb927.6.5110
uniprot id: Q586I3
names: Similarity
messages: Belongs to the DDB1 family.

185431:Tb10.70.6650
gene id: 185431:Tb10.70.6650
uniprot id: Q38CA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

185431:Tb927.4.1360
gene id: 185431:Tb927.4.1360
uniprot id: Q581U5
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.

185431:Tb10.61.2290
gene id: 185431:Tb10.61.2290
uniprot id: Q388F8
names: Subcellular Location Annotation
messages: cilium basal body

185431:Tb09.160.4680
gene id: 185431:Tb09.160.4680
uniprot id: Q38ET8
names: Similarity
messages: Belongs to the Rab GDI family.

185431:Tb10.61.3060
gene id: 185431:Tb10.61.3060
uniprot id: Q388L3
names: Function
names: Similarity
messages: Belongs to the peptidase C13 family.
messages: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.

185431:Tb09.211.3810
gene id: 185431:Tb09.211.3810
uniprot id: Q38DC8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

185431:Tb927.6.1520
gene id: 185431:Tb927.6.1520
uniprot id: Q585Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

185431:Tb927.8.5530
gene id: 185431:Tb927.8.5530
uniprot id: Q57X29
names: Similarity
messages: Belongs to the peptidase M67A family. CSN5 subfamily.

185431:Tb10.6k15.3050
gene id: 185431:Tb10.6k15.3050
uniprot id: Q38AK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POC5 family.
messages: Essential for the assembly of the distal half of centrioles, required for centriole elongation.
messages: centriole

185431:Tb09.211.3610
gene id: 185431:Tb09.211.3610
uniprot id: Q38DE8
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

185431:Tb927.6.4900
gene id: 185431:Tb927.6.4900
uniprot id: Q586G3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

185431:Tb10.61.1850
gene id: 185431:Tb10.61.1850
uniprot id: Q387N8
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.4.3910
gene id: 185431:Tb927.4.3910
uniprot id: Q57XZ5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.4.1090
gene id: 185431:Tb927.4.1090
uniprot id: Q580D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

185431:Tb927.6.1690
gene id: 185431:Tb927.6.1690
uniprot id: Q585P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

185431:Tb09.211.4350
gene id: 185431:Tb09.211.4350
uniprot id: Q38D76
names: Similarity
messages: Belongs to the CAF1 family.

185431:Tb927.4.840
gene id: 185431:Tb927.4.840
uniprot id: Q580B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

185431:Tb927.5.2700
gene id: 185431:Tb927.5.2700
uniprot id: Q57ZU6
names: Similarity
messages: Belongs to the peptidase C65 family.

185431:Tb927.4.3670
gene id: 185431:Tb927.4.3670
uniprot id: Q585I3
names: Similarity
messages: Belongs to the CBF/MAK21 family.

185431:Tb927.6.1030
gene id: 185431:Tb927.6.1030
uniprot id: Q585E3
names: Similarity
messages: Belongs to the peptidase C1 family.

185431:Tb927.8.1180
gene id: 185431:Tb927.8.1180
uniprot id: Q57VN6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

185431:Tb09.211.2900
gene id: 185431:Tb09.211.2900
uniprot id: Q38DL5
names: Similarity
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.

185431:Tb09.160.0530
gene id: 185431:Tb09.160.0530
uniprot id: Q38FY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

185431:Tb927.7.390
gene id: 185431:Tb927.7.390
uniprot id: Q57U15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:TB927.1.05
gene id: 185431:TB927.1.05
uniprot id: Q4GZE7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.2.2670
gene id: 185431:Tb927.2.2670
uniprot id: Q587H6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the histone H4 family.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb10.389.1260
gene id: 185431:Tb10.389.1260
uniprot id: Q388Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

185431:TB927.1.4050
gene id: 185431:TB927.1.4050
uniprot id: Q4GYH2
names: Similarity
messages: Belongs to the PPP phosphatase family.

185431:Tb927.5.4730
gene id: 185431:Tb927.5.4730
uniprot id: Q57X39
names: Function
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.5.3360
gene id: 185431:Tb927.5.3360
uniprot id: Q57Z57
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

185431:Tb927.2.6240
gene id: 185431:Tb927.2.6240
uniprot id: Q586M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

185431:Tb10.70.7440
gene id: 185431:Tb10.70.7440
uniprot id: Q38CG3
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

185431:Tb927.8.1940
gene id: 185431:Tb927.8.1940
uniprot id: Q581Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

185431:Tb927.6.4990
gene id: 185431:Tb927.6.4990
uniprot id: Q586H1
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

185431:Tb10.6k15.0030
gene id: 185431:Tb10.6k15.0030
uniprot id: Q389V2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Major surface antigen of procyclic forms.
messages: Membrane

185431:Tb09.160.5250
gene id: 185431:Tb09.160.5250
uniprot id: Q38EM6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

185431:Tb927.8.6750
gene id: 185431:Tb927.8.6750
uniprot id: Q57TT8
names: Similarity
messages: Belongs to the TCTP family.

185431:Tb927.3.2510
gene id: 185431:Tb927.3.2510
uniprot id: Q582W4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:TB927.1.4740
gene id: 185431:TB927.1.4740
uniprot id: Q4GYA4
names: Similarity
messages: Belongs to the FAM91 family.

185431:Tb10.6k15.0340
gene id: 185431:Tb10.6k15.0340
uniprot id: Q389Y2
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.7.1470
gene id: 185431:Tb927.7.1470
uniprot id: Q57WQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

185431:Tb927.8.1980
gene id: 185431:Tb927.8.1980
uniprot id: Q581Y4
names: Subcellular Location Annotation
messages: nucleolus

185431:Tb10.70.7080
gene id: 185431:Tb10.70.7080
uniprot id: Q38CD5
names: Similarity
messages: Belongs to the peptidase S10 family.

185431:Tb927.3.590
gene id: 185431:Tb927.3.590
uniprot id: Q57TQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

185431:Tb09.160.5580
gene id: 185431:Tb09.160.5580
uniprot id: Q38EI9
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

185431:Tb09.160.3850
gene id: 185431:Tb09.160.3850
uniprot id: Q38F20
names: Similarity
messages: Belongs to the actin family.

185431:Tb927.6.3090
gene id: 185431:Tb927.6.3090
uniprot id: Q583M5
names: Similarity
messages: Belongs to the TOG/XMAP215 family.

185431:TB927.1.540
gene id: 185431:TB927.1.540
uniprot id: Q4GZE8
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

185431:Tb10.389.1270
gene id: 185431:Tb10.389.1270
uniprot id: Q388Z9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.8.680
gene id: 185431:Tb927.8.680
uniprot id: Q57YG2
names: Subcellular Location Annotation
messages: Mitochondrion

185431:Tb927.8.1750
gene id: 185431:Tb927.8.1750
uniprot id: D6XKR2
uniprot id: Q582A7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase (PubMed:25040552). Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity).
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Monomer.
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

185431:Tb927.5.1880
gene id: 185431:Tb927.5.1880
uniprot id: D6XGC6
uniprot id: Q57ZQ7
names: Similarity
messages: Belongs to the protease inhibitor I11 (ecotin) family.

185431:Tb927.3.1500
gene id: 185431:Tb927.3.1500
uniprot id: Q57XY3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.8.3860
gene id: 185431:Tb927.8.3860
uniprot id: Q581A6
names: Function
names: Similarity
messages: Belongs to the WD repeat CIA1 family.
messages: Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.

185431:Tb09.211.2090
gene id: 185431:Tb09.211.2090
uniprot id: Q38DU8
names: Subcellular Location Annotation
messages: Nucleus

185431:Tb09.160.4690
gene id: 185431:Tb09.160.4690
uniprot id: Q38ET7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

185431:Tb09.211.2920
gene id: 185431:Tb09.211.2920
uniprot id: Q38DL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

185431:Tb09.142.0230
gene id: 185431:Tb09.142.0230
uniprot id: Q38G42
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.6.4090
gene id: 185431:Tb927.6.4090
uniprot id: Q586A7
names: Function
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.
messages: Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.

185431:Tb927.5.4270
gene id: 185431:Tb927.5.4270
uniprot id: Q57Z22
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.

185431:Tb09.160.4450
gene id: 185431:Tb09.160.4450
uniprot id: Q38EW1
names: Similarity
messages: Belongs to the universal ribosomal protein uS3 family.

185431:Tb10.70.3000
gene id: 185431:Tb10.70.3000
uniprot id: Q38BH5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

185431:Tb927.7.3840
gene id: 185431:Tb927.7.3840
uniprot id: D6XIR5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb09.211.3030
gene id: 185431:Tb09.211.3030
uniprot id: Q38DK3
names: Similarity
messages: Belongs to the peroxidase family.

185431:Tb927.8.3290
gene id: 185431:Tb927.8.3290
uniprot id: Q57YY4
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

185431:Tb10.70.6450
gene id: 185431:Tb10.70.6450
uniprot id: Q38C90
names: Subcellular Location Annotation
messages: Nucleus

185431:Tb927.6.700
gene id: 185431:Tb927.6.700
uniprot id: Q583T3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm
messages: Mitochondrion
messages: Monomer.

185431:Tb927.3.3280
gene id: 185431:Tb927.3.3280
uniprot id: Q57V58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Membrane

185431:Tb927.3.5180
gene id: 185431:Tb927.3.5180
uniprot id: Q580V7
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

185431:Tb927.8.3500
gene id: 185431:Tb927.8.3500
uniprot id: Q57YW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MET18/MMS19 family.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus

185431:Tb927.6.3290
gene id: 185431:Tb927.6.3290
uniprot id: Q584X2
names: Subcellular Location Annotation
messages: cilium

185431:Tb927.4.1810
gene id: 185431:Tb927.4.1810
uniprot id: Q581Q0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

185431:Tb927.2.2950
gene id: 185431:Tb927.2.2950
uniprot id: Q587G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

185431:Tb10.61.0490
gene id: 185431:Tb10.61.0490
uniprot id: Q387T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

185431:Tb10.70.4870
gene id: 185431:Tb10.70.4870
uniprot id: Q38BW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

185431:Tb927.7.3010
gene id: 185431:Tb927.7.3010
uniprot id: Q57YB1
names: Similarity
messages: Belongs to the NPR2 family.

185431:Tb927.7.2870
gene id: 185431:Tb927.7.2870
uniprot id: Q57YA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:TB927.1.1580
gene id: 185431:TB927.1.1580
uniprot id: Q4GZ61
names: Similarity
messages: Belongs to the SCO1/2 family.

185431:Tb927.2.3370
gene id: 185431:Tb927.2.3370
uniprot id: Q587E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb927.3.1520
gene id: 185431:Tb927.3.1520
uniprot id: Q57XY0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:TB927.1.3820
gene id: 185431:TB927.1.3820
uniprot id: Q4GYJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

185431:Tb09.160.4180
gene id: 185431:Tb09.160.4180
uniprot id: Q38EY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: phagosome membrane

185431:Tb927.4.4350
gene id: 185431:Tb927.4.4350
uniprot id: Q57Y39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

185431:Tb927.8.4150
gene id: 185431:Tb927.8.4150
uniprot id: Q581D5
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.389.0480
gene id: 185431:Tb10.389.0480
uniprot id: Q388U4
names: Similarity
messages: Belongs to the VPS16 family.

185431:Tb927.8.1510
gene id: 185431:Tb927.8.1510
uniprot id: Q580H2
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.

185431:Tb10.70.0770
gene id: 185431:Tb10.70.0770
uniprot id: Q38AZ6
names: Function
names: Similarity
messages: Belongs to the queuosine salvage protein family.
messages: Involved in salvaging queuosine.

185431:Tb927.4.3560
gene id: 185431:Tb927.4.3560
uniprot id: Q585J4
names: Similarity
messages: Belongs to the PPP phosphatase family.

185431:Tb927.6.1780
gene id: 185431:Tb927.6.1780
uniprot id: Q585N3
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

185431:Tb09.211.2150
gene id: 185431:Tb09.211.2150
uniprot id: Q38DU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

185431:Tb927.6.1060
gene id: 185431:Tb927.6.1060
uniprot id: Q585E2
names: Similarity
messages: Belongs to the peptidase C1 family.

185431:Tb10.70.0080
gene id: 185431:Tb10.70.0080
uniprot id: Q38AT8
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb927.3.4390
gene id: 185431:Tb927.3.4390
uniprot id: Q580K3
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

185431:Tb927.6.770
gene id: 185431:Tb927.6.770
uniprot id: Q583S6
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.3.1780
gene id: 185431:Tb927.3.1780
uniprot id: D6XD86
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

185431:Tb927.8.5060
gene id: 185431:Tb927.8.5060
uniprot id: Q57UH8
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

185431:Tb09.244.2200
gene id: 185431:Tb09.244.2200
uniprot id: Q38CT5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.4.4210
gene id: 185431:Tb927.4.4210
uniprot id: Q57Y25
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

185431:Tb10.70.3290
gene id: 185431:Tb10.70.3290
uniprot id: Q38BK1
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.

185431:Tb927.8.2630
gene id: 185431:Tb927.8.2630
uniprot id: Q57XC6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb10.6k15.1090
gene id: 185431:Tb10.6k15.1090
uniprot id: Q38A43
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.8.3910
gene id: 185431:Tb927.8.3910
uniprot id: Q581B1
names: Similarity
messages: Belongs to the thymidylate kinase family.

185431:Tb927.2.2370
gene id: 185431:Tb927.2.2370
uniprot id: Q586L0
names: Similarity
messages: Belongs to the COG1 family.

185431:Tb927.8.1860
gene id: 185431:Tb927.8.1860
uniprot id: Q581Z6
names: Similarity
messages: Belongs to the peptidase M16 family.

185431:Tb927.2.2990
gene id: 185431:Tb927.2.2990
uniprot id: Q587G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

185431:Tb927.8.5810
gene id: 185431:Tb927.8.5810
uniprot id: Q57YI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

185431:Tb927.7.5480
gene id: 185431:Tb927.7.5480
uniprot id: Q582G3
names: Function
names: Similarity
messages: Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
messages: In the C-terminal section; belongs to the thymidylate synthase family.
messages: In the N-terminal section; belongs to the dihydrofolate reductase family.

185431:Tb927.5.3520
gene id: 185431:Tb927.5.3520
uniprot id: Q57UB4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit and an accessory subunit.
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

185431:Tb09.244.1580
gene id: 185431:Tb09.244.1580
uniprot id: Q38CQ2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.7.7520
gene id: 185431:Tb927.7.7520
uniprot id: Q57TY9
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.5.580
gene id: 185431:Tb927.5.580
uniprot id: Q57VV5
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

185431:Tb927.2.6050
gene id: 185431:Tb927.2.6050
uniprot id: Q586P1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

185431:Tb927.6.1640
gene id: 185431:Tb927.6.1640
uniprot id: Q585P6
names: Similarity
messages: Belongs to the nuclease type I family.

185431:Tb09.211.2570
gene id: 185431:Tb09.211.2570
uniprot id: Q38DP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.

185431:Tb10.70.7840
gene id: 185431:Tb10.70.7840
uniprot id: Q38CJ1
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

185431:Tb927.8.7400
gene id: 185431:Tb927.8.7400
uniprot id: Q57YU2
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

185431:Tb927.8.8330
gene id: 185431:Tb927.8.8330
uniprot id: Q57WJ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb10.70.0570
gene id: 185431:Tb10.70.0570
uniprot id: Q38AY0
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

185431:Tb927.8.7980
gene id: 185431:Tb927.8.7980
uniprot id: Q57U47
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.70.2970
gene id: 185431:Tb10.70.2970
uniprot id: Q38BH2
names: Similarity
messages: Belongs to the UQCRB/QCR7 family.

185431:Tb927.3.3720
gene id: 185431:Tb927.3.3720
uniprot id: Q57WA8
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.2.5120
gene id: 185431:Tb927.2.5120
uniprot id: Q585V8
names: Similarity
messages: Belongs to the synaptobrevin family.

185431:Tb10.70.6950
gene id: 185431:Tb10.70.6950
uniprot id: Q4FKF8
names: Similarity
messages: Belongs to the tubulin family.

185431:Tb10.389.1360
gene id: 185431:Tb10.389.1360
uniprot id: Q389A6
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

185431:Tb927.2.4840
gene id: 185431:Tb927.2.4840
uniprot id: Q586S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

185431:Tb10.70.1560
gene id: 185431:Tb10.70.1560
uniprot id: Q38B58
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

185431:Tb927.4.2230
gene id: 185431:Tb927.4.2230
uniprot id: Q584G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

185431:TB927.1.2430
gene id: 185431:TB927.1.2430
uniprot id: Q4GYX7
names: Similarity
messages: Belongs to the histone H3 family.

185431:TB927.1.2450
gene id: 185431:TB927.1.2450
uniprot id: Q4GYX7
names: Similarity
messages: Belongs to the histone H3 family.

185431:Tb927.3.1240
gene id: 185431:Tb927.3.1240
uniprot id: Q57XV7
names: Similarity
messages: Belongs to the PPP phosphatase family.

185431:Tb927.8.1710
gene id: 185431:Tb927.8.1710
uniprot id: Q580F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

185431:Tb10.70.6800
gene id: 185431:Tb10.70.6800
uniprot id: Q38CB4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.

185431:Tb09.160.5550
gene id: 185431:Tb09.160.5550
uniprot id: Q38EJ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb927.6.200
gene id: 185431:Tb927.6.200
uniprot id: Q581D6
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.7.5900
gene id: 185431:Tb927.7.5900
uniprot id: Q582K5
names: Similarity
messages: Belongs to the ATG8 family.

185431:Tb927.8.2200
gene id: 185431:Tb927.8.2200
uniprot id: Q581W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

185431:Tb927.4.5790
gene id: 185431:Tb927.4.5790
uniprot id: Q580N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb927.4.1050
gene id: 185431:Tb927.4.1050
uniprot id: Q580D3
names: Domain
names: Function
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

185431:Tb927.3.4410
gene id: 185431:Tb927.3.4410
uniprot id: Q580K1
names: Similarity
messages: Belongs to the PIH1 family.

185431:Tb927.7.5990
gene id: 185431:Tb927.7.5990
uniprot id: Q57VL2
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.406.0260
gene id: 185431:Tb10.406.0260
uniprot id: Q389R3
names: Similarity
messages: Belongs to the NARF family.

185431:Tb927.8.1560
gene id: 185431:Tb927.8.1560
uniprot id: Q580G7
names: Subcellular Location Annotation
messages: Cytoplasm

185431:Tb927.3.3410
gene id: 185431:Tb927.3.3410
uniprot id: Q57V45
names: Similarity
messages: Belongs to the peptidase M18 family.

185431:Tb10.6k15.0390
gene id: 185431:Tb10.6k15.0390
uniprot id: Q389Y6
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

185431:Tb927.6.3280
gene id: 185431:Tb927.6.3280
uniprot id: Q584X1
names: Similarity
messages: Belongs to the APC1 family.

185431:Tb09.211.0450
gene id: 185431:Tb09.211.0450
uniprot id: Q38EB4
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.6k15.0970
gene id: 185431:Tb10.6k15.0970
uniprot id: Q38A32
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

185431:Tb927.4.5430
gene id: 185431:Tb927.4.5430
uniprot id: Q580P4
names: Function
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.8.5510
gene id: 185431:Tb927.8.5510
uniprot id: Q57X31
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

185431:Tb927.4.3750
gene id: 185431:Tb927.4.3750
uniprot id: Q583G9
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.7.6470
gene id: 185431:Tb927.7.6470
uniprot id: Q582L2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
messages: Component of the EKC/KEOPS complex; the whole complex dimerizes.
messages: Cytoplasm
messages: Nucleus

185431:Tb927.2.5190
gene id: 185431:Tb927.2.5190
uniprot id: Q585V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

185431:Tb927.8.2640
gene id: 185431:Tb927.8.2640
uniprot id: Q57XC5
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

185431:Tb927.7.7360
gene id: 185431:Tb927.7.7360
uniprot id: Q57TX3
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.8.7530
gene id: 185431:Tb927.8.7530
uniprot id: Q57V74
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

185431:Tb927.7.2230
gene id: 185431:Tb927.7.2230
uniprot id: Q57XQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

185431:Tb927.3.4360
gene id: 185431:Tb927.3.4360
uniprot id: Q580K6
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

185431:Tb927.4.3610
gene id: 185431:Tb927.4.3610
uniprot id: Q585I9
names: Similarity
messages: Belongs to the PPP phosphatase family.

185431:Tb927.8.7900
gene id: 185431:Tb927.8.7900
uniprot id: Q57U54
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb10.70.0260
gene id: 185431:Tb10.70.0260
uniprot id: Q38AV3
names: Subcellular Location Annotation
messages: Membrane

185431:TB927.1.5170
gene id: 185431:TB927.1.5170
uniprot id: Q4GY64
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.6.1140
gene id: 185431:Tb927.6.1140
uniprot id: Q585D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

185431:Tb10.70.7750
gene id: 185431:Tb10.70.7750
uniprot id: Q38CI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

185431:Tb927.8.5210
gene id: 185431:Tb927.8.5210
uniprot id: Q57UJ3
names: Similarity
messages: Belongs to the cullin family.

185431:Tb927.6.1370
gene id: 185431:Tb927.6.1370
uniprot id: Q585B0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.2.4410
gene id: 185431:Tb927.2.4410
uniprot id: Q586P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

185431:Tb927.8.6330
gene id: 185431:Tb927.8.6330
uniprot id: Q57YN4
names: Subcellular Location Annotation
messages: Cytoplasm

185431:Tb10.70.5950
gene id: 185431:Tb10.70.5950
uniprot id: Q38C53
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb09.160.0110
gene id: 185431:Tb09.160.0110
uniprot id: Q38G20
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.8.3750
gene id: 185431:Tb927.8.3750
uniprot id: Q580Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

185431:Tb927.4.1100
gene id: 185431:Tb927.4.1100
uniprot id: Q580D8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

185431:Tb927.7.5170
gene id: 185431:Tb927.7.5170
uniprot id: Q57ZH2
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

185431:Tb927.3.960
gene id: 185431:Tb927.3.960
uniprot id: Q57WX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

185431:Tb09.244.2740
gene id: 185431:Tb09.244.2740
uniprot id: Q38CY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

185431:Tb927.7.5650
gene id: 185431:Tb927.7.5650
uniprot id: Q582I0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.6.4540
gene id: 185431:Tb927.6.4540
uniprot id: Q587C0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb927.3.3020
gene id: 185431:Tb927.3.3020
uniprot id: Q57ZL0
names: Similarity
messages: Belongs to the actin family.

185431:Tb927.8.3920
gene id: 185431:Tb927.8.3920
uniprot id: Q581B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MET18/MMS19 family.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus

185431:Tb10.70.5540
gene id: 185431:Tb10.70.5540
uniprot id: Q38C23
names: Similarity
messages: Belongs to the peptidase C19 family.

185431:Tb09.211.1510
gene id: 185431:Tb09.211.1510
uniprot id: Q38E05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus

185431:Tb927.7.5760
gene id: 185431:Tb927.7.5760
uniprot id: Q582J1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

185431:Tb09.160.0815
gene id: 185431:Tb09.160.0815
uniprot id: Q38FV6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

185431:Tb927.3.4720
gene id: 185431:Tb927.3.4720
uniprot id: Q582R3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

185431:Tb09.211.2370
gene id: 185431:Tb09.211.2370
uniprot id: Q38DS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

185431:TB927.1.1680
gene id: 185431:TB927.1.1680
uniprot id: Q4GZ51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

185431:Tb927.4.2670
gene id: 185431:Tb927.4.2670
uniprot id: D6XFK3
names: Similarity
messages: Belongs to the peptidase C15 family.

185431:Tb927.8.1960
gene id: 185431:Tb927.8.1960
uniprot id: Q581Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT11 family.
messages: Cytoplasm
messages: Nucleus

185431:Tb10.70.0480
gene id: 185431:Tb10.70.0480
uniprot id: Q38AX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: cytoskeleton

185431:Tb927.3.3110
gene id: 185431:Tb927.3.3110
uniprot id: Q57ZK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

185431:Tb927.6.2970
gene id: 185431:Tb927.6.2970
uniprot id: Q583N7
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

185431:Tb927.5.4220
gene id: 185431:Tb927.5.4220
uniprot id: Q57Z31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the histone H4 family.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.8.3140
gene id: 185431:Tb927.8.3140
uniprot id: Q57YZ9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Mitochondrion matrix
messages: NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

185431:Tb10.61.1530
gene id: 185431:Tb10.61.1530
uniprot id: Q388A7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

185431:Tb927.7.1930
gene id: 185431:Tb927.7.1930
uniprot id: Q57V17
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

185431:Tb10.389.1220
gene id: 185431:Tb10.389.1220
uniprot id: Q388Z5
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.61.3080
gene id: 185431:Tb10.61.3080
uniprot id: Q388L5
names: Similarity
messages: Belongs to the FAM221 family.

185431:TB927.1.4890
gene id: 185431:TB927.1.4890
uniprot id: Q4GY91
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb09.211.4500
gene id: 185431:Tb09.211.4500
uniprot id: Q38D61
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

185431:Tb927.7.1590
gene id: 185431:Tb927.7.1590
uniprot id: Q57WP1
names: Similarity
messages: Belongs to the cyclin family.

185431:Tb10.389.0120
gene id: 185431:Tb10.389.0120
uniprot id: Q388R6
names: Similarity
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.

185431:Tb927.5.450
gene id: 185431:Tb927.5.450
uniprot id: Q57VW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

185431:Tb927.2.4850
gene id: 185431:Tb927.2.4850
uniprot id: Q586S7
names: Similarity
messages: Belongs to the phosducin family.

185431:Tb10.70.4280
gene id: 185431:Tb10.70.4280
uniprot id: Q38BS5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

185431:Tb927.6.1090
gene id: 185431:Tb927.6.1090
uniprot id: D6XHJ3
names: Similarity
messages: Belongs to the AAA ATPase family.

185431:Tb927.7.6360
gene id: 185431:Tb927.7.6360
uniprot id: Q582M3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.6.800
gene id: 185431:Tb927.6.800
uniprot id: Q583S3
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb10.406.0450
gene id: 185431:Tb10.406.0450
uniprot id: Q389T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb10.61.2130
gene id: 185431:Tb10.61.2130
uniprot id: Q388E8
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.

185431:Tb927.5.1830
gene id: 185431:Tb927.5.1830
uniprot id: Q57ZQ2
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

185431:Tb927.4.5250
gene id: 185431:Tb927.4.5250
uniprot id: Q584H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb09.244.2700
gene id: 185431:Tb09.244.2700
uniprot id: Q38CY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

185431:Tb927.8.590
gene id: 185431:Tb927.8.590
uniprot id: Q57YH1
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

185431:Tb09.211.3460
gene id: 185431:Tb09.211.3460
uniprot id: Q38DG0
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

185431:Tb927.8.1800
gene id: 185431:Tb927.8.1800
uniprot id: Q582A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

185431:Tb927.7.300
gene id: 185431:Tb927.7.300
uniprot id: Q57U24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:TB927.1.1350
gene id: 185431:TB927.1.1350
uniprot id: Q4GZ84
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb10.406.0420
gene id: 185431:Tb10.406.0420
uniprot id: Q389T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.5.1700
gene id: 185431:Tb927.5.1700
uniprot id: Q57ZN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 2 family.
messages: Nucleus

185431:Tb927.6.1760
gene id: 185431:Tb927.6.1760
uniprot id: Q585N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus

185431:Tb927.6.1020
gene id: 185431:Tb927.6.1020
uniprot id: Q585E5
names: Similarity
messages: Belongs to the peptidase C1 family.

185431:Tb927.7.4420
gene id: 185431:Tb927.7.4420
uniprot id: Q57X58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.

185431:Tb927.6.5040
gene id: 185431:Tb927.6.5040
uniprot id: Q586H6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

185431:Tb927.8.1330
gene id: 185431:Tb927.8.1330
uniprot id: Q57VM1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

185431:Tb927.7.3500
gene id: 185431:Tb927.7.3500
uniprot id: Q57WG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily.
messages: Membrane

185431:Tb927.7.370
gene id: 185431:Tb927.7.370
uniprot id: Q57U17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb10.70.6780
gene id: 185431:Tb10.70.6780
uniprot id: Q38CB2
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.6.2890
gene id: 185431:Tb927.6.2890
uniprot id: Q583P5
names: Similarity
messages: Belongs to the nuclease type I family.

185431:Tb927.8.1810
gene id: 185431:Tb927.8.1810
uniprot id: Q582A1
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.5.2860
gene id: 185431:Tb927.5.2860
uniprot id: Q57ZW2
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.70.3360
gene id: 185431:Tb10.70.3360
uniprot id: Q38BK6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).
messages: Cytoplasm

185431:Tb09.211.3180
gene id: 185431:Tb09.211.3180
uniprot id: Q38DI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

185431:Tb927.7.5910
gene id: 185431:Tb927.7.5910
uniprot id: Q582K6
names: Similarity
messages: Belongs to the ATG8 family.

185431:Tb927.3.1360
gene id: 185431:Tb927.3.1360
uniprot id: Q57XW9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

185431:Tb927.6.1310
gene id: 185431:Tb927.6.1310
uniprot id: Q585B6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.6.1770
gene id: 185431:Tb927.6.1770
uniprot id: Q585N4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb09.160.4560
gene id: 185431:Tb09.160.4560
uniprot id: Q38EV2
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

185431:Tb09.211.3630
gene id: 185431:Tb09.211.3630
uniprot id: Q38DE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Mitochondrion inner membrane

185431:Tb09.211.2590
gene id: 185431:Tb09.211.2590
uniprot id: Q38DP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

185431:Tb927.7.6170
gene id: 185431:Tb927.7.6170
uniprot id: Q57VJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

185431:Tb927.8.7460
gene id: 185431:Tb927.8.7460
uniprot id: Q57YU8
names: Subcellular Location Annotation
messages: Membrane

185431:Tb09.244.2630
gene id: 185431:Tb09.244.2630
uniprot id: Q38CX3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

185431:Tb927.5.3350
gene id: 185431:Tb927.5.3350
uniprot id: Q57Z58
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

185431:Tb09.160.4280
gene id: 185431:Tb09.160.4280
uniprot id: Q38EX8
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

185431:Tb927.2.2060
gene id: 185431:Tb927.2.2060
uniprot id: Q586J1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.6.980
gene id: 185431:Tb927.6.980
uniprot id: Q585F0
names: Similarity
messages: Belongs to the peptidase C1 family.

185431:Tb927.6.4780
gene id: 185431:Tb927.6.4780
uniprot id: Q587E4
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.

185431:Tb10.70.1730
gene id: 185431:Tb10.70.1730
uniprot id: Q38B69
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

185431:Tb927.3.2440
gene id: 185431:Tb927.3.2440
uniprot id: Q582V7
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb927.8.6020
gene id: 185431:Tb927.8.6020
uniprot id: Q57YK3
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

185431:Tb10.6k15.0110
gene id: 185431:Tb10.6k15.0110
uniprot id: Q389W0
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

185431:Tb10.6k15.3170
gene id: 185431:Tb10.6k15.3170
uniprot id: Q38AL5
names: Similarity
messages: Belongs to the cullin family.

185431:Tb927.4.5390
gene id: 185431:Tb927.4.5390
uniprot id: Q580P8
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb09.211.2910
gene id: 185431:Tb09.211.2910
uniprot id: Q38DL4
names: Similarity
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.

185431:Tb10.70.5840
gene id: 185431:Tb10.70.5840
uniprot id: Q38C44
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Nucleus
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport.
messages: The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs).

185431:Tb927.6.4470
gene id: 185431:Tb927.6.4470
uniprot id: Q587B3
names: Similarity
messages: Belongs to the eukaryotic AdoMetDC family.

185431:Tb10.61.1020
gene id: 185431:Tb10.61.1020
uniprot id: Q387X4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb927.4.1860
gene id: 185431:Tb927.4.1860
uniprot id: Q583K7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

185431:Tb927.7.6500
gene id: 185431:Tb927.7.6500
uniprot id: Q57Y76
names: Function
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.3.1540
gene id: 185431:Tb927.3.1540
uniprot id: Q57XY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

185431:Tb09.211.2970
gene id: 185431:Tb09.211.2970
uniprot id: Q38DK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family.
messages: Nucleus

185431:Tb927.7.6280
gene id: 185431:Tb927.7.6280
uniprot id: Q57VI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme

185431:Tb927.7.6230
gene id: 185431:Tb927.7.6230
uniprot id: Q57VI8
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

185431:Tb927.3.210
gene id: 185431:Tb927.3.210
uniprot id: Q57TR7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.6k15.2350
gene id: 185431:Tb10.6k15.2350
uniprot id: Q38AE7
names: Similarity
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.

185431:Tb927.8.2160
gene id: 185431:Tb927.8.2160
uniprot id: Q581W6
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.6.4810
gene id: 185431:Tb927.6.4810
uniprot id: Q586F3
names: Similarity
messages: Belongs to the yippee family.

185431:Tb09.160.5390
gene id: 185431:Tb09.160.5390
uniprot id: Q38EL3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.4.3580
gene id: 185431:Tb927.4.3580
uniprot id: Q585J0
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

185431:TB927.1.1660
gene id: 185431:TB927.1.1660
uniprot id: Q4GZ53
names: Similarity
messages: Belongs to the acetyltransferase family. ECO subfamily.

185431:Tb927.6.1880
gene id: 185431:Tb927.6.1880
uniprot id: Q585M3
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.

185431:Tb927.8.2770
gene id: 185431:Tb927.8.2770
uniprot id: Q57XB2
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.3.1290
gene id: 185431:Tb927.3.1290
uniprot id: Q57XW2
names: Similarity
messages: Belongs to the cullin family.

185431:Tb10.6k15.3940
gene id: 185431:Tb10.6k15.3940
uniprot id: Q38AS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBS4 family.
messages: Membrane
messages: centrosome
messages: cilium membrane

185431:Tb927.5.4410
gene id: 185431:Tb927.5.4410
uniprot id: Q57Z08
names: Similarity
messages: Belongs to the RRP15 family.

185431:Tb09.354.0060
gene id: 185431:Tb09.354.0060
uniprot id: Q38G47
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.70.2290
gene id: 185431:Tb10.70.2290
uniprot id: Q38BB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

185431:Tb927.5.3170
gene id: 185431:Tb927.5.3170
uniprot id: Q57Z76
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

185431:Tb09.160.2050
gene id: 185431:Tb09.160.2050
uniprot id: Q38FI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeSI family.
messages: Belongs to the glycosyl hydrolase 85 family.
messages: cytosol

185431:Tb09.160.5240
gene id: 185431:Tb09.160.5240
uniprot id: Q38EM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Mitochondrion

185431:Tb927.3.1970
gene id: 185431:Tb927.3.1970
uniprot id: Q57ZB4
names: Similarity
messages: Belongs to the PPC synthetase family.

185431:Tb927.6.4850
gene id: 185431:Tb927.6.4850
uniprot id: Q586G3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

185431:Tb927.4.760
gene id: 185431:Tb927.4.760
uniprot id: Q580A4
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

185431:Tb927.5.1300
gene id: 185431:Tb927.5.1300
uniprot id: Q57VD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

185431:Tb10.70.6210
gene id: 185431:Tb10.70.6210
uniprot id: Q38C73
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.

185431:Tb09.211.1010
gene id: 185431:Tb09.211.1010
uniprot id: Q38E55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target (By similarity).
messages: Membrane

185431:Tb927.8.7870
gene id: 185431:Tb927.8.7870
uniprot id: Q57U56
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb927.8.5980
gene id: 185431:Tb927.8.5980
uniprot id: Q57YJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

185431:Tb927.8.550
gene id: 185431:Tb927.8.550
uniprot id: Q57YH5
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

185431:Tb09.v1.0380
gene id: 185431:Tb09.v1.0380
uniprot id: Q38EH6
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

185431:Tb927.3.1760
gene id: 185431:Tb927.3.1760
uniprot id: Q57ZD5
names: Similarity
messages: Belongs to the HscB family.

185431:Tb09.160.4430
gene id: 185431:Tb09.160.4430
uniprot id: Q38EW4
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.

185431:Tb927.5.800
gene id: 185431:Tb927.5.800
uniprot id: Q57W25
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb09.211.3200
gene id: 185431:Tb09.211.3200
uniprot id: Q38DI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

185431:Tb927.4.2390
gene id: 185431:Tb927.4.2390
uniprot id: Q584E8
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

185431:Tb927.8.3100
gene id: 185431:Tb927.8.3100
uniprot id: Q57W63
names: Similarity
messages: Belongs to the WD repeat coronin family.

185431:TB927.1.2340
gene id: 185431:TB927.1.2340
uniprot id: Q4GYY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

185431:Tb927.3.340
gene id: 185431:Tb927.3.340
uniprot id: Q57TR6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.7.2310
gene id: 185431:Tb927.7.2310
uniprot id: Q57XP3
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

185431:Tb927.8.1080
gene id: 185431:Tb927.8.1080
uniprot id: Q57VP6
names: Similarity
messages: Belongs to the centrin family.

185431:Tb927.8.6940
gene id: 185431:Tb927.8.6940
uniprot id: Q57YQ1
names: Similarity
messages: Belongs to the CFAP43 family.

185431:Tb09.244.0640
gene id: 185431:Tb09.244.0640
uniprot id: Q38CP2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb09.211.0620
gene id: 185431:Tb09.211.0620
uniprot id: Q38E94
names: Similarity
messages: Belongs to the actin family.

185431:Tb10.70.0250
gene id: 185431:Tb10.70.0250
uniprot id: Q38AV2
names: Similarity
messages: Belongs to the PPP phosphatase family.

185431:Tb927.4.1330
gene id: 185431:Tb927.4.1330
uniprot id: Q581U8
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

185431:Tb09.160.2460
gene id: 185431:Tb09.160.2460
uniprot id: Q38FE7
names: Similarity
messages: Belongs to the dymeclin family.

185431:Tb927.8.6030
gene id: 185431:Tb927.8.6030
uniprot id: Q57YK4
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

185431:Tb927.4.1070
gene id: 185431:Tb927.4.1070
uniprot id: Q580D5
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

185431:Tb10.6k15.0070
gene id: 185431:Tb10.6k15.0070
uniprot id: Q389V6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

185431:Tb10.406.0340
gene id: 185431:Tb10.406.0340
uniprot id: Q389S0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.8.4660
gene id: 185431:Tb927.8.4660
uniprot id: Q57UY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Nucleus

185431:Tb927.7.1910
gene id: 185431:Tb927.7.1910
uniprot id: Q57V19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvP family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

185431:Tb927.8.480
gene id: 185431:Tb927.8.480
uniprot id: Q57XI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

185431:Tb927.4.1840
gene id: 185431:Tb927.4.1840
uniprot id: Q583K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Midbody
messages: Nucleus
messages: spindle

185431:Tb09.160.0810
gene id: 185431:Tb09.160.0810
uniprot id: Q38FV7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb927.2.6090
gene id: 185431:Tb927.2.6090
uniprot id: D7SG81
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

185431:Tb927.8.3620
gene id: 185431:Tb927.8.3620
uniprot id: Q580Y2
names: Subcellular Location Annotation
messages: Membrane

185431:Tb10.70.6620
gene id: 185431:Tb10.70.6620
uniprot id: Q38C98
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm

185431:Tb10.70.0370
gene id: 185431:Tb10.70.0370
uniprot id: Q38AW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

185431:Tb10.05.0230
gene id: 185431:Tb10.05.0230
uniprot id: Q388P7
names: Similarity
messages: Belongs to the AAA ATPase family.

185431:Tb927.4.5010
gene id: 185431:Tb927.4.5010
uniprot id: Q584K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

185431:Tb927.8.3400
gene id: 185431:Tb927.8.3400
uniprot id: Q57YX3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

185431:Tb09.v1.0300
gene id: 185431:Tb09.v1.0300
uniprot id: Q38EK8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.7.6150
gene id: 185431:Tb927.7.6150
uniprot id: Q57VJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

185431:Tb927.4.2180
gene id: 185431:Tb927.4.2180
uniprot id: Q584G9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

185431:Tb927.4.5410
gene id: 185431:Tb927.4.5410
uniprot id: Q580P5
names: Function
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.3.3910
gene id: 185431:Tb927.3.3910
uniprot id: Q57WC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: Nucleus

185431:Tb927.5.2530
gene id: 185431:Tb927.5.2530
uniprot id: Q582B4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

185431:Tb927.3.1270
gene id: 185431:Tb927.3.1270
uniprot id: Q57XW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus
messages: Required for pre-mRNA splicing.

185431:Tb927.7.3160
gene id: 185431:Tb927.7.3160
uniprot id: Q57YC6
names: Similarity
messages: Belongs to the dynein heavy chain family.

185431:Tb927.5.4460
gene id: 185431:Tb927.5.4460
uniprot id: Q57Z03
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Nucleus
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport (By similarity).
messages: The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs) (By similarity).

185431:Tb927.3.4910
gene id: 185431:Tb927.3.4910
uniprot id: Q582P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

185431:Tb927.5.4190
gene id: 185431:Tb927.5.4190
uniprot id: Q57Z31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the histone H4 family.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb927.6.1870
gene id: 185431:Tb927.6.1870
uniprot id: Q585M4
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

185431:Tb927.3.2090
gene id: 185431:Tb927.3.2090
uniprot id: Q57ZA2
names: Similarity
messages: Belongs to the peptidase M24B family.

185431:Tb10.6k15.0170
gene id: 185431:Tb10.6k15.0170
uniprot id: Q389W6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

185431:Tb10.6k15.0490
gene id: 185431:Tb10.6k15.0490
uniprot id: Q389Z4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

185431:Tb10.61.0630
gene id: 185431:Tb10.61.0630
uniprot id: Q387U5
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

185431:Tb10.406.0440
gene id: 185431:Tb10.406.0440
uniprot id: Q389T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:TB927.1.2210
gene id: 185431:TB927.1.2210
uniprot id: Q4GZ00
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

185431:Tb927.6.4770
gene id: 185431:Tb927.6.4770
uniprot id: Q587E3
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although it belongs to the XPG/RAD2 endonuclease family, only two of the seven Asp residues involved in Mg(2+) binding are conserved suggesting that it has no nuclease activity.
messages: Belongs to the XPG/RAD2 endonuclease family.
messages: Expressed in the procyclic and bloodstream forms (at protein level).
messages: Forms a complex composed of at least MKT1, PBP1, XAC1 and LSM12 (PubMed:32532821). Within the complex, interacts (via C-terminus) with PBP1; the interaction is direct (PubMed:32532821, PubMed:24470144). Interacts with RNA-binding protein ZC3H11 (via MKT1-binding motif); the interaction is direct (PubMed:32532821, PubMed:24470144). May interact with RNA-binding proteins CFB1 and CFB2 (PubMed:32532821). Interacts with the EIF4E6-EIF4G5 translation initiation complex via EIF4G5; the interaction with EIF4G5 is direct (PubMed:32532821).
messages: Involved in post-transcriptional regulation of gene expression (PubMed:24470144). Promotes mRNA stabilization by recruiting a complex containing PBP1, LSM12 and XAC1 to mRNAs (PubMed:24470144, PubMed:32532821). Recruited to mRNAs by sequence-specific RNA binding proteins (PubMed:24470144). May regulate translation through interactions with the EIF4E6-EIF4G5 translation initiation complex (PubMed:32532821).
messages: RNAI-mediated knockdown in the bloodstream form is lethal (PubMed:24470144). RNAi-mediated knockdown in the procyclic form has no effect on viability (PubMed:24470144).
messages: Stress granule
messages: cytosol

185431:Tb927.4.440
gene id: 185431:Tb927.4.440
uniprot id: Q57UT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFB11 subunit family.
messages: Membrane

185431:Tb10.389.0530
gene id: 185431:Tb10.389.0530
uniprot id: Q388U8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

185431:Tb927.3.4760
gene id: 185431:Tb927.3.4760
uniprot id: Q582Q9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

185431:Tb10.389.0340
gene id: 185431:Tb10.389.0340
uniprot id: Q388T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

185431:Tb10.26.0860
gene id: 185431:Tb10.26.0860
uniprot id: Q389M3
names: Similarity
messages: Belongs to the NifU family.

185431:Tb10.70.3150
gene id: 185431:Tb10.70.3150
uniprot id: Q38BI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Mitochondrion inner membrane

185431:Tb10.05.0010
gene id: 185431:Tb10.05.0010
uniprot id: Q388P2
names: Function
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

185431:Tb10.61.1230
gene id: 185431:Tb10.61.1230
uniprot id: Q387Y5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC56 family.
messages: Gene knockout results in significant reduction of flagellar beating and cell swimming, and absence of outer dynein arms in the distal region of flagellum axoneme. Cell motility is characterized by an erratic swimming pattern with altered propagation of the tip-to-base wave, increased frequency of base-to-tip waves, and frequent tumbling typical of outer dynein arm mutants.
messages: Required for the assembly of dynein arms in the distal portion of flagellum axoneme.
messages: flagellum

185431:Tb927.2.4210
gene id: 185431:Tb927.2.4210
uniprot id: Q586V2
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

185431:Tb927.5.1250
gene id: 185431:Tb927.5.1250
uniprot id: Q57VD8
names: Similarity
messages: Belongs to the TIP41 family.

185431:Tb927.5.4330
gene id: 185431:Tb927.5.4330
uniprot id: Q57Z16
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

185431:Tb927.7.3670
gene id: 185431:Tb927.7.3670
uniprot id: Q57WI2
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

185431:Tb10.70.1770
gene id: 185431:Tb10.70.1770
uniprot id: Q38B73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit.
messages: nucleolus

185431:Tb927.7.2780
gene id: 185431:Tb927.7.2780
uniprot id: Q57Y88
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Expressed in the bloodstream form (at protein level).
messages: Forms a complex composed of at least MKT1, PBP1, XAC1 and LSM12 (PubMed:32532821). Forms a complex composed of at least MKT1L, PBP1, XAC1 and LSM12 (PubMed:32532821).
messages: Involved in post-transcriptional regulation of gene expression.
messages: RNAi-mediated knockdown in the bloodstream form abolishes cell population growth.

185431:Tb10.70.3160
gene id: 185431:Tb10.70.3160
uniprot id: Q38BI8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

185431:Tb927.6.990
gene id: 185431:Tb927.6.990
uniprot id: Q585E8
names: Similarity
messages: Belongs to the peptidase C1 family.

185431:TB927.1.5300
gene id: 185431:TB927.1.5300
uniprot id: Q4GY52
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.8.1110
gene id: 185431:Tb927.8.1110
uniprot id: Q57VP3
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

185431:Tb09.160.0700
gene id: 185431:Tb09.160.0700
uniprot id: Q38FW8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

185431:Tb927.4.2020
gene id: 185431:Tb927.4.2020
uniprot id: Q583J1
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

185431:Tb10.406.0390
gene id: 185431:Tb10.406.0390
uniprot id: Q389S5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

185431:Tb10.26.0190
gene id: 185431:Tb10.26.0190
uniprot id: Q389H0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb10.70.6220
gene id: 185431:Tb10.70.6220
uniprot id: Q38C74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

185431:Tb09.160.5590
gene id: 185431:Tb09.160.5590
uniprot id: Q38EI9
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

185431:Tb09.211.1760
gene id: 185431:Tb09.211.1760
uniprot id: Q38DX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Polyamine:cation symporter (PHS) (TC 2.A.3.12) family.
messages: Membrane

185431:Tb927.6.1420
gene id: 185431:Tb927.6.1420
uniprot id: Q585A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

185431:Tb09.160.1990
gene id: 185431:Tb09.160.1990
uniprot id: Q38FJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

185431:Tb927.5.1550
gene id: 185431:Tb927.5.1550
uniprot id: Q57VA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

185431:Tb927.2.6270
gene id: 185431:Tb927.2.6270
uniprot id: Q586M8
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

185431:Tb10.70.5110
gene id: 185431:Tb10.70.5110
uniprot id: Q38BY9
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

185431:Tb927.3.3320
gene id: 185431:Tb927.3.3320
uniprot id: Q57V54
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

185431:Tb927.2.2260
gene id: 185431:Tb927.2.2260
uniprot id: Q586K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Nucleus

185431:Tb09.160.0970
gene id: 185431:Tb09.160.0970
uniprot id: Q38FU0
names: Similarity
messages: Belongs to the peptidase C48 family.

185431:Tb927.8.2560
gene id: 185431:Tb927.8.2560
uniprot id: Q57XD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus

185431:Tb09.211.3760
gene id: 185431:Tb09.211.3760
uniprot id: Q38DD3
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

185431:Tb927.4.4460
gene id: 185431:Tb927.4.4460
uniprot id: Q583D1
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb10.6k15.0430
gene id: 185431:Tb10.6k15.0430
uniprot id: Q389Y9
names: Similarity
messages: Belongs to the CFAP298 family.

185431:TB927.1.1600
gene id: 185431:TB927.1.1600
uniprot id: Q4GZ59
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

185431:Tb10.70.2260
gene id: 185431:Tb10.70.2260
uniprot id: Q38BA7
names: Similarity
messages: Belongs to the protein kinase superfamily.

185431:Tb09.160.0260
gene id: 185431:Tb09.160.0260
uniprot id: Q38G16
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.7.1730
gene id: 185431:Tb927.7.1730
uniprot id: Q57V37
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

185431:Tb927.6.4460
gene id: 185431:Tb927.6.4460
uniprot id: Q587A7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.

185431:Tb927.3.570
gene id: 185431:Tb927.3.570
uniprot id: Q57TQ9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb927.6.4920
gene id: 185431:Tb927.6.4920
uniprot id: Q586G3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

185431:Tb927.5.2760
gene id: 185431:Tb927.5.2760
uniprot id: Q57ZV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

185431:Tb927.5.3220
gene id: 185431:Tb927.5.3220
uniprot id: Q57Z71
names: Similarity
messages: Belongs to the peptidase S26B family.

185431:Tb927.8.2480
gene id: 185431:Tb927.8.2480
uniprot id: Q57XE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

185431:Tb10.6k15.2130
gene id: 185431:Tb10.6k15.2130
uniprot id: Q38AC8
names: Similarity
messages: Belongs to the CAF1 family.

185431:Tb10.61.1920
gene id: 185431:Tb10.61.1920
uniprot id: Q388C9
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

185431:Tb09.211.4990
gene id: 185431:Tb09.211.4990
uniprot id: Q38D10
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

185431:Tb927.3.1400
gene id: 185431:Tb927.3.1400
uniprot id: Q57XX3
names: Function
names: Similarity
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.

185431:Tb927.3.5270
gene id: 185431:Tb927.3.5270
uniprot id: Q580U8
names: Subcellular Location Annotation
messages: Nucleus

185431:Tb927.6.310
gene id: 185431:Tb927.6.310
uniprot id: Q581E3
names: Function
messages: Could act as a receptor for an unknown ligand.

185431:Tb09.v4.0005
gene id: 185431:Tb09.v4.0005
uniprot id: Q4FKU3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb09.211.4460
gene id: 185431:Tb09.211.4460
uniprot id: Q38D65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

185431:Tb10.70.1100
gene id: 185431:Tb10.70.1100
uniprot id: Q38B20
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

185431:Tb927.8.7320
gene id: 185431:Tb927.8.7320
uniprot id: Q57YT4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb09.211.0220
gene id: 185431:Tb09.211.0220
uniprot id: Q38ED9
names: Subcellular Location Annotation
messages: Membrane

185431:Tb927.8.2100
gene id: 185431:Tb927.8.2100
uniprot id: D6XKU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Vacuole membrane

185431:Tb927.7.5680
gene id: 185431:Tb927.7.5680
uniprot id: Q582I3
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

185431:Tb927.6.5260
gene id: 185431:Tb927.6.5260
uniprot id: Q583L7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.70.7260
gene id: 185431:Tb10.70.7260
uniprot id: Q38CF1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

185431:Tb09.211.1780
gene id: 185431:Tb09.211.1780
uniprot id: Q38DX6
names: Similarity
messages: Belongs to the MIP18 family.

185431:Tb927.6.3340
gene id: 185431:Tb927.6.3340
uniprot id: Q584X7
names: Similarity
messages: Belongs to the CCDC25 family.

185431:Tb927.8.2610
gene id: 185431:Tb927.8.2610
uniprot id: Q57XC8
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

185431:Tb927.6.480
gene id: 185431:Tb927.6.480
uniprot id: Q581F6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Major surface antigen of procyclic forms.
messages: Membrane

185431:Tb927.4.4710
gene id: 185431:Tb927.4.4710
uniprot id: Q583F6
names: Subcellular Location Annotation
messages: Cytoplasm

185431:Tb927.7.2510
gene id: 185431:Tb927.7.2510
uniprot id: Q57XM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

185431:Tb10.26.0260
gene id: 185431:Tb10.26.0260
uniprot id: Q389H7
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.

185431:Tb09.160.1560
gene id: 185431:Tb09.160.1560
uniprot id: Q38FN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

185431:Tb927.3.1700
gene id: 185431:Tb927.3.1700
uniprot id: Q57ZE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

185431:Tb927.6.4760
gene id: 185431:Tb927.6.4760
uniprot id: Q587E2
names: Similarity
messages: Belongs to the TCP11 family.

185431:Tb927.4.1340
gene id: 185431:Tb927.4.1340
uniprot id: Q581U7
names: Subcellular Location Annotation
messages: Nucleus

185431:Tb927.3.2280
gene id: 185431:Tb927.3.2280
uniprot id: Q582U1
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

185431:Tb927.8.1490
gene id: 185431:Tb927.8.1490
uniprot id: Q580H4
names: Similarity
messages: Belongs to the SDHAF4 family.

185431:Tb927.7.2060
gene id: 185431:Tb927.7.2060
uniprot id: Q57V05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

185431:Tb10.61.0610
gene id: 185431:Tb10.61.0610
uniprot id: Q387U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

185431:Tb927.6.4660
gene id: 185431:Tb927.6.4660
uniprot id: D6XIJ5
names: Subcellular Location Annotation
messages: Membrane

185431:TB927.1.2550
gene id: 185431:TB927.1.2550
uniprot id: Q4GYX7
names: Similarity
messages: Belongs to the histone H3 family.

185431:Tb10.70.4900
gene id: 185431:Tb10.70.4900
uniprot id: Q38BX0
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by DHSp. Inhibited by spermididine analog N1-guanyl-1,7-diamineoheptane (GC7).
messages: Belongs to the deoxyhypusine synthase family.
messages: Heterotetramer formed by a homodimer of the non-catalytic regulatory subunit DHSp and a homodimer of the catalytic subunit DHSc where DHSc appears to bind spermidine and DHSp appears to bind NAD(+).
messages: In association with the non-catalytic regulatory subunit DHSp, catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF5A precursor protein to form the intermediate deoxyhypusine residue. Regulates protein levels of its regulatory subunit DHSp. Required for cell growth and survival.
messages: Membrane
messages: RNAi-mediated knockdown causes cell growth arrest followed by death, loss of DHSp expression and a failure to sustain infection in mice.
messages: The binding sites for NAD(+) are contained in the regulatory subunit DHSp.

185431:Tb927.5.4030
gene id: 185431:Tb927.5.4030
uniprot id: D6XGY7
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

185431:Tb927.3.4790
gene id: 185431:Tb927.3.4790
uniprot id: Q582Q6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

185431:Tb927.7.2340
gene id: 185431:Tb927.7.2340
uniprot id: Q57XN7
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

185431:Tb10.61.2630
gene id: 185431:Tb10.61.2630
uniprot id: Q388I4
names: Similarity
messages: Belongs to the WD repeat SEC13 family.

185431:Tb10.70.2650
gene id: 185431:Tb10.70.2650
uniprot id: Q38BE4
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

185431:Tb09.160.3710
gene id: 185431:Tb09.160.3710
uniprot id: Q38F34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

185431:Tb927.8.1720
gene id: 185431:Tb927.8.1720
uniprot id: Q582B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

185431:Tb927.7.2550
gene id: 185431:Tb927.7.2550
uniprot id: Q57XL9
names: Similarity
messages: Belongs to the AAA ATPase family.

185431:Tb927.8.6090
gene id: 185431:Tb927.8.6090
uniprot id: Q57YL0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

185431:Tb927.7.2440
gene id: 185431:Tb927.7.2440
uniprot id: Q57XN0
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

185431:TB927.1.2370
gene id: 185431:TB927.1.2370
uniprot id: Q4GYY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

185431:Tb927.5.1820
gene id: 185431:Tb927.5.1820
uniprot id: Q57ZQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: P1 and P2 exist as dimers at the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

185431:Tb09.211.3570
gene id: 185431:Tb09.211.3570
uniprot id: Q38DF0
names: Similarity
messages: Belongs to the FGGY kinase family.

185431:Tb09.244.0250
gene id: 185431:Tb09.244.0250
uniprot id: Q38CN2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.

185431:Tb10.61.1910
gene id: 185431:Tb10.61.1910
uniprot id: Q388C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

185431:Tb927.6.1610
gene id: 185431:Tb927.6.1610
uniprot id: Q585P9
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

185431:Tb927.6.3650
gene id: 185431:Tb927.6.3650
uniprot id: Q585W3
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.