177437:HRM2 RS16070
gene id: 177437:HRM2_RS16070
uniprot id: C0QLN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS13185
gene id: 177437:HRM2_RS13185
uniprot id: C0QI21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

177437:HRM2 RS11690
gene id: 177437:HRM2_RS11690
uniprot id: C0QFN0
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS17510
gene id: 177437:HRM2_RS17510
uniprot id: C0Q9A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

177437:HRM2 RS24085
gene id: 177437:HRM2_RS24085
uniprot id: C0QIH2
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

177437:HRM2 RS17365
gene id: 177437:HRM2_RS17365
uniprot id: C0Q978
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

177437:HRM2 RS04780
gene id: 177437:HRM2_RS04780
uniprot id: C0QKL2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

177437:HRM2 RS03020
gene id: 177437:HRM2_RS03020
uniprot id: C0QIU5
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

177437:HRM2 RS09450
gene id: 177437:HRM2_RS09450
uniprot id: C0QBY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

177437:HRM2 RS15345
gene id: 177437:HRM2_RS15345
uniprot id: C0QKV1
names: Similarity
messages: Belongs to the CmpA/NrtA family.

177437:HRM2 RS18770
gene id: 177437:HRM2_RS18770
uniprot id: C0QAT0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS21215
gene id: 177437:HRM2_RS21215
uniprot id: C0QDT9
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

177437:HRM2 RS02570
gene id: 177437:HRM2_RS02570
uniprot id: C0QHS5
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase involved in purine salvage.

177437:HRM2 RS12405
gene id: 177437:HRM2_RS12405
uniprot id: C0QGU0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

177437:HRM2 RS15995
gene id: 177437:HRM2_RS15995
uniprot id: C0QLL6
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

177437:HRM2 RS10900
gene id: 177437:HRM2_RS10900
uniprot id: C0QDN6
names: Similarity
messages: Belongs to the MlaA family.

177437:HRM2 RS12490
gene id: 177437:HRM2_RS12490
uniprot id: C0QGV7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

177437:HRM2 RS12720
gene id: 177437:HRM2_RS12720
uniprot id: C0QH02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

177437:HRM2 RS22320
gene id: 177437:HRM2_RS22320
uniprot id: C0QF81
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

177437:HRM2 RS07965
gene id: 177437:HRM2_RS07965
uniprot id: C0QAC7
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS03375
gene id: 177437:HRM2_RS03375
uniprot id: C0QJ20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

177437:HRM2 RS12315
gene id: 177437:HRM2_RS12315
uniprot id: C0QG03
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.

177437:HRM2 RS07770
gene id: 177437:HRM2_RS07770
uniprot id: C0QA84
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS12425
gene id: 177437:HRM2_RS12425
uniprot id: C0QGU4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

177437:HRM2 RS18345
gene id: 177437:HRM2_RS18345
uniprot id: C0QAJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

177437:HRM2 RS08100
gene id: 177437:HRM2_RS08100
uniprot id: C0QAF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

177437:HRM2 RS06740
gene id: 177437:HRM2_RS06740
uniprot id: C0Q8X5
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

177437:HRM2 RS13825
gene id: 177437:HRM2_RS13825
uniprot id: C0QJ70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

177437:HRM2 RS15370
gene id: 177437:HRM2_RS15370
uniprot id: C0QKV6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

177437:HRM2 RS21285
gene id: 177437:HRM2_RS21285
uniprot id: C0QDV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.
messages: Golgi apparatus
messages: Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.
messages: In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.
messages: In the N-terminal section; belongs to the formiminotransferase family.
messages: centriole

177437:HRM2 RS13675
gene id: 177437:HRM2_RS13675
uniprot id: C0QJ40
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS00670
gene id: 177437:HRM2_RS00670
uniprot id: C0QEE7
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

177437:HRM2 RS10955
gene id: 177437:HRM2_RS10955
uniprot id: C0QDP5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

177437:HRM2 RS23625
gene id: 177437:HRM2_RS23625
uniprot id: C0QHG7
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

177437:HRM2 RS06545
gene id: 177437:HRM2_RS06545
uniprot id: C0Q8U0
names: Similarity
messages: Belongs to the myoviridae tail sheath protein family.

177437:HRM2 RS22360
gene id: 177437:HRM2_RS22360
uniprot id: C0QF89
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

177437:HRM2 RS14935
gene id: 177437:HRM2_RS14935
uniprot id: C0QK82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

177437:HRM2 RS04225
gene id: 177437:HRM2_RS04225
uniprot id: C0QKA3
names: Similarity
messages: Belongs to the FBPase class 3 family.

177437:HRM2 RS02470
gene id: 177437:HRM2_RS02470
uniprot id: C0QHQ5
names: Similarity
messages: Belongs to the GSP E family.

177437:HRM2 RS18905
gene id: 177437:HRM2_RS18905
uniprot id: C0QAV6
names: Similarity
messages: Belongs to the universal stress protein A family.

177437:HRM2 RS11340
gene id: 177437:HRM2_RS11340
uniprot id: C0QEN8
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS20150
gene id: 177437:HRM2_RS20150
uniprot id: C0QCC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS00470
gene id: 177437:HRM2_RS00470
uniprot id: C0QEA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

177437:HRM2 RS27710
gene id: 177437:HRM2_RS27710
uniprot id: C0QJW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

177437:HRM2 RS17435
gene id: 177437:HRM2_RS17435
uniprot id: C0Q991
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
messages: Membrane

177437:HRM2 RS01635
gene id: 177437:HRM2_RS01635
uniprot id: C0QGI1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

177437:HRM2 RS24885
gene id: 177437:HRM2_RS24885
uniprot id: C0QIR8
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS04520
gene id: 177437:HRM2_RS04520
uniprot id: C0QKG3
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

177437:HRM2 RS17875
gene id: 177437:HRM2_RS17875
uniprot id: C0Q9W8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

177437:HRM2 RS15300
gene id: 177437:HRM2_RS15300
uniprot id: C0QKU2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

177437:HRM2 RS25540
gene id: 177437:HRM2_RS25540
uniprot id: C0QBL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS25480
gene id: 177437:HRM2_RS25480
uniprot id: C0QA29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

177437:HRM2 RS13550
gene id: 177437:HRM2_RS13550
uniprot id: C0QI92
names: Similarity
messages: Belongs to the LarC family.

177437:HRM2 RS13880
gene id: 177437:HRM2_RS13880
uniprot id: C0QJ81
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS00145
gene id: 177437:HRM2_RS00145
uniprot id: C0QE39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS16020
gene id: 177437:HRM2_RS16020
uniprot id: C0QLM1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

177437:HRM2 RS15495
gene id: 177437:HRM2_RS15495
uniprot id: C0QKY0
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

177437:HRM2 RS20170
gene id: 177437:HRM2_RS20170
uniprot id: C0QCD0
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

177437:HRM2 RS11255
gene id: 177437:HRM2_RS11255
uniprot id: C0QEM2
names: Similarity
messages: Belongs to the UPF0047 family.

177437:HRM2 RS00300
gene id: 177437:HRM2_RS00300
uniprot id: C0QE69
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS04710
gene id: 177437:HRM2_RS04710
uniprot id: C0QKJ8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

177437:HRM2 RS04170
gene id: 177437:HRM2_RS04170
uniprot id: C0QK92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS17370
gene id: 177437:HRM2_RS17370
uniprot id: C0Q979
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

177437:HRM2 RS01785
gene id: 177437:HRM2_RS01785
uniprot id: C0QGK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

177437:HRM2 RS24090
gene id: 177437:HRM2_RS24090
uniprot id: C0QIH3
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

177437:HRM2 RS14970
gene id: 177437:HRM2_RS14970
uniprot id: C0QKM6
names: Similarity
messages: Belongs to the class-D beta-lactamase family.
messages: Belongs to the peptidase S13 family.

177437:HRM2 RS13500
gene id: 177437:HRM2_RS13500
uniprot id: C0QI82
names: Similarity
messages: Belongs to the DprA/Smf family.

177437:HRM2 RS10345
gene id: 177437:HRM2_RS10345
uniprot id: C0QDC4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

177437:HRM2 RS07895
gene id: 177437:HRM2_RS07895
uniprot id: C0QAB1
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS11055
gene id: 177437:HRM2_RS11055
uniprot id: C0QEI7
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

177437:HRM2 RS22455
gene id: 177437:HRM2_RS22455
uniprot id: C0QG30
names: Similarity
messages: Belongs to the peptidase S8 family.

177437:HRM2 RS09675
gene id: 177437:HRM2_RS09675
uniprot id: C0QCH3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

177437:HRM2 RS20905
gene id: 177437:HRM2_RS20905
uniprot id: C0QD66
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

177437:HRM2 RS01965
gene id: 177437:HRM2_RS01965
uniprot id: C0QGP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

177437:HRM2 RS04220
gene id: 177437:HRM2_RS04220
uniprot id: C0QKA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS07875
gene id: 177437:HRM2_RS07875
uniprot id: C0QAA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

177437:HRM2 RS11580
gene id: 177437:HRM2_RS11580
uniprot id: C0QET5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

177437:HRM2 RS02675
gene id: 177437:HRM2_RS02675
uniprot id: C0QHU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS04340
gene id: 177437:HRM2_RS04340
uniprot id: C0QKC6
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

177437:HRM2 RS07255
gene id: 177437:HRM2_RS07255
uniprot id: C0Q9J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

177437:HRM2 RS17275
gene id: 177437:HRM2_RS17275
uniprot id: C0Q965
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS16685
gene id: 177437:HRM2_RS16685
uniprot id: C0QMD8
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS06615
gene id: 177437:HRM2_RS06615
uniprot id: C0Q8V2
names: Function
names: Similarity
messages: Belongs to the ATPase gamma chain family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

177437:HRM2 RS08570
gene id: 177437:HRM2_RS08570
uniprot id: C0QB30
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.

177437:HRM2 RS11145
gene id: 177437:HRM2_RS11145
uniprot id: C0QEK5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS20820
gene id: 177437:HRM2_RS20820
uniprot id: C0QD50
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

177437:HRM2 RS17410
gene id: 177437:HRM2_RS17410
uniprot id: C0Q987
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

177437:HRM2 RS14920
gene id: 177437:HRM2_RS14920
uniprot id: C0QK77
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS03085
gene id: 177437:HRM2_RS03085
uniprot id: C0QIV8
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS16540
gene id: 177437:HRM2_RS16540
uniprot id: C0QMA9
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

177437:HRM2 RS23845
gene id: 177437:HRM2_RS23845
uniprot id: C0QIC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS19825
gene id: 177437:HRM2_RS19825
uniprot id: C0QC62
names: Similarity
messages: Belongs to the universal stress protein A family.

177437:HRM2 RS06080
gene id: 177437:HRM2_RS06080
uniprot id: C0QM31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Periplasm

177437:HRM2 RS11095
gene id: 177437:HRM2_RS11095
uniprot id: C0QEJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

177437:HRM2 RS05385
gene id: 177437:HRM2_RS05385
uniprot id: C0QLB7
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

177437:HRM2 RS21590
gene id: 177437:HRM2_RS21590
uniprot id: C0QE13
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

177437:HRM2 RS01600
gene id: 177437:HRM2_RS01600
uniprot id: C0QGH3
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.

177437:HRM2 RS06005
gene id: 177437:HRM2_RS06005
uniprot id: C0QM17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS20810
gene id: 177437:HRM2_RS20810
uniprot id: C0QD48
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

177437:HRM2 RS17730
gene id: 177437:HRM2_RS17730
uniprot id: C0Q9T6
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

177437:HRM2 RS23075
gene id: 177437:HRM2_RS23075
uniprot id: C0QGE7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS12595
gene id: 177437:HRM2_RS12595
uniprot id: C0QGX9
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

177437:HRM2 RS22730
gene id: 177437:HRM2_RS22730
uniprot id: C0QG82
names: Function
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

177437:HRM2 RS01645
gene id: 177437:HRM2_RS01645
uniprot id: C0QGI3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

177437:HRM2 RS05470
gene id: 177437:HRM2_RS05470
uniprot id: C0QLD4
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

177437:HRM2 RS08310
gene id: 177437:HRM2_RS08310
uniprot id: C0QAY2
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

177437:HRM2 RS05745
gene id: 177437:HRM2_RS05745
uniprot id: C0QLW8
names: Similarity
messages: Belongs to the HypE family.

177437:HRM2 RS17525
gene id: 177437:HRM2_RS17525
uniprot id: C0Q9A6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

177437:HRM2 RS11675
gene id: 177437:HRM2_RS11675
uniprot id: C0QFM8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

177437:HRM2 RS12385
gene id: 177437:HRM2_RS12385
uniprot id: C0QGT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

177437:HRM2 RS22925
gene id: 177437:HRM2_RS22925
uniprot id: C0QGB6
names: Similarity
messages: Belongs to the SlyX family.

177437:HRM2 RS17885
gene id: 177437:HRM2_RS17885
uniprot id: C0Q9X0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

177437:HRM2 RS11085
gene id: 177437:HRM2_RS11085
uniprot id: C0QEJ3
names: Similarity
messages: Belongs to the peptidase A31 family.

177437:HRM2 RS07880
gene id: 177437:HRM2_RS07880
uniprot id: C0QAA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

177437:HRM2 RS13830
gene id: 177437:HRM2_RS13830
uniprot id: C0QJ71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

177437:HRM2 RS15745
gene id: 177437:HRM2_RS15745
uniprot id: C0QLG6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

177437:HRM2 RS15035
gene id: 177437:HRM2_RS15035
uniprot id: C0QKN9
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

177437:HRM2 RS18500
gene id: 177437:HRM2_RS18500
uniprot id: C0QAM4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

177437:HRM2 RS15195
gene id: 177437:HRM2_RS15195
uniprot id: C0QKS2
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

177437:HRM2 RS22505
gene id: 177437:HRM2_RS22505
uniprot id: C0QG39
names: Similarity
messages: Belongs to the P(II) protein family.

177437:HRM2 RS15680
gene id: 177437:HRM2_RS15680
uniprot id: C0QLF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

177437:HRM2 RS18410
gene id: 177437:HRM2_RS18410
uniprot id: C0QAK6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

177437:HRM2 RS18615
gene id: 177437:HRM2_RS18615
uniprot id: C0QAP7
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS15040
gene id: 177437:HRM2_RS15040
uniprot id: C0QKP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

177437:HRM2 RS15840
gene id: 177437:HRM2_RS15840
uniprot id: C0QLI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

177437:HRM2 RS03440
gene id: 177437:HRM2_RS03440
uniprot id: C0QJ33
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

177437:HRM2 RS11725
gene id: 177437:HRM2_RS11725
uniprot id: C0QFN7
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

177437:HRM2 RS24450
gene id: 177437:HRM2_RS24450
uniprot id: C0QIP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

177437:HRM2 RS04525
gene id: 177437:HRM2_RS04525
uniprot id: C0QKG4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

177437:HRM2 RS15085
gene id: 177437:HRM2_RS15085
uniprot id: C0QKP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TolB family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: Periplasm
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

177437:HRM2 RS18640
gene id: 177437:HRM2_RS18640
uniprot id: C0QAQ2
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS02165
gene id: 177437:HRM2_RS02165
uniprot id: C0QHJ8
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

177437:HRM2 RS05025
gene id: 177437:HRM2_RS05025
uniprot id: C0QL45
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

177437:HRM2 RS00390
gene id: 177437:HRM2_RS00390
uniprot id: C0QE88
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

177437:HRM2 RS17060
gene id: 177437:HRM2_RS17060
uniprot id: C0Q924
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kinesin light chain family.
messages: cytoskeleton

177437:HRM2 RS24660
gene id: 177437:HRM2_RS24660
uniprot id: C0QMP8
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

177437:HRM2 RS08850
gene id: 177437:HRM2_RS08850
uniprot id: C0QB81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flotillin-like FloA family.
messages: Cell membrane
messages: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.
messages: Homooligomerizes.
messages: Membrane raft

177437:HRM2 RS08490
gene id: 177437:HRM2_RS08490
uniprot id: C0QB14
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

177437:HRM2 RS02510
gene id: 177437:HRM2_RS02510
uniprot id: C0QHR3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

177437:HRM2 RS03650
gene id: 177437:HRM2_RS03650
uniprot id: C0QJK9
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

177437:HRM2 RS04990
gene id: 177437:HRM2_RS04990
uniprot id: C0QL38
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

177437:HRM2 RS02965
gene id: 177437:HRM2_RS02965
uniprot id: C0QIT4
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

177437:HRM2 RS23995
gene id: 177437:HRM2_RS23995
uniprot id: C0QIF4
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS02505
gene id: 177437:HRM2_RS02505
uniprot id: C0QHR2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

177437:HRM2 RS22275
gene id: 177437:HRM2_RS22275
uniprot id: C0QF72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

177437:HRM2 RS01020
gene id: 177437:HRM2_RS01020
uniprot id: C0QFD8
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

177437:HRM2 RS11080
gene id: 177437:HRM2_RS11080
uniprot id: C0QEJ2
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

177437:HRM2 RS24315
gene id: 177437:HRM2_RS24315
uniprot id: C0QIM1
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS11540
gene id: 177437:HRM2_RS11540
uniprot id: C0QES7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

177437:HRM2 RS09105
gene id: 177437:HRM2_RS09105
uniprot id: C0QBR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

177437:HRM2 RS08920
gene id: 177437:HRM2_RS08920
uniprot id: C0QB95
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

177437:HRM2 RS12015
gene id: 177437:HRM2_RS12015
uniprot id: C0QFU2
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

177437:HRM2 RS20690
gene id: 177437:HRM2_RS20690
uniprot id: C0QD22
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

177437:HRM2 RS11460
gene id: 177437:HRM2_RS11460
uniprot id: C0QER1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP E family.
messages: Cytoplasm

177437:HRM2 RS00835
gene id: 177437:HRM2_RS00835
uniprot id: C0QFA0
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

177437:HRM2 RS08135
gene id: 177437:HRM2_RS08135
uniprot id: C0QAG2
names: Similarity
messages: Belongs to the MotB family.

177437:HRM2 RS11945
gene id: 177437:HRM2_RS11945
uniprot id: C0QFT1
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

177437:HRM2 RS05955
gene id: 177437:HRM2_RS05955
uniprot id: C0QM06
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the epimerization of L-Lys-L-Arg to L-Lys-D-Arg (in vitro). Catalyzes the epimerization of positively charged dipeptides, with a preference for substrates with a basic amino acid in the second position. Has epimerase activity with L-Lys-L-Lys, L-Arg-L-Arg, L-Val-L-Arg, L-Val-L-Lys and L-Ala-L-Arg (in vitro).
messages: Part of a large, functionally divergent protein family. Protein modeling and substrate docking was used to predict the substrate specificity, prior to biochemical analysis.

177437:HRM2 RS09765
gene id: 177437:HRM2_RS09765
uniprot id: C0QCJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

177437:HRM2 RS17795
gene id: 177437:HRM2_RS17795
uniprot id: C0Q9V0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

177437:HRM2 RS09470
gene id: 177437:HRM2_RS09470
uniprot id: C0QBZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

177437:HRM2 RS00840
gene id: 177437:HRM2_RS00840
uniprot id: C0QFA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

177437:HRM2 RS04455
gene id: 177437:HRM2_RS04455
uniprot id: C0QKE9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS22405
gene id: 177437:HRM2_RS22405
uniprot id: C0QG20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS23795
gene id: 177437:HRM2_RS23795
uniprot id: C0QIB5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

177437:HRM2 RS13170
gene id: 177437:HRM2_RS13170
uniprot id: C0QI18
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

177437:HRM2 RS02865
gene id: 177437:HRM2_RS02865
uniprot id: C0QIR5
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

177437:HRM2 RS01960
gene id: 177437:HRM2_RS01960
uniprot id: C0QGP1
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

177437:HRM2 RS04245
gene id: 177437:HRM2_RS04245
uniprot id: C0QKA7
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

177437:HRM2 RS22640
gene id: 177437:HRM2_RS22640
uniprot id: C0QG66
names: Similarity
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

177437:HRM2 RS05190
gene id: 177437:HRM2_RS05190
uniprot id: C0QL79
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

177437:HRM2 RS03345
gene id: 177437:HRM2_RS03345
uniprot id: C0QJ14
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

177437:HRM2 RS02640
gene id: 177437:HRM2_RS02640
uniprot id: C0QHT9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

177437:HRM2 RS09745
gene id: 177437:HRM2_RS09745
uniprot id: C0QCI9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS14760
gene id: 177437:HRM2_RS14760
uniprot id: C0QK45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

177437:HRM2 RS13755
gene id: 177437:HRM2_RS13755
uniprot id: C0QJ56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

177437:HRM2 RS11390
gene id: 177437:HRM2_RS11390
uniprot id: C0QEP8
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

177437:HRM2 RS00220
gene id: 177437:HRM2_RS00220
uniprot id: C0QE54
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

177437:HRM2 RS12470
gene id: 177437:HRM2_RS12470
uniprot id: C0QGV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

177437:HRM2 RS13430
gene id: 177437:HRM2_RS13430
uniprot id: C0QI68
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.
messages: Membrane

177437:HRM2 RS02310
gene id: 177437:HRM2_RS02310
uniprot id: C0QHM4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

177437:HRM2 RS20005
gene id: 177437:HRM2_RS20005
uniprot id: C0QC97
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

177437:HRM2 RS01325
gene id: 177437:HRM2_RS01325
uniprot id: C0QFJ7
names: Similarity
messages: Belongs to the citrate synthase family.

177437:HRM2 RS17285
gene id: 177437:HRM2_RS17285
uniprot id: C0Q967
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS19075
gene id: 177437:HRM2_RS19075
uniprot id: C0QBC3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

177437:HRM2 RS25075
gene id: 177437:HRM2_RS25075
uniprot id: C0QAC6
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

177437:HRM2 RS14670
gene id: 177437:HRM2_RS14670
uniprot id: C0QK26
names: Similarity
messages: Belongs to the heat shock protein 70 family.

177437:HRM2 RS08040
gene id: 177437:HRM2_RS08040
uniprot id: C0QAE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

177437:HRM2 RS18820
gene id: 177437:HRM2_RS18820
uniprot id: C0QAU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS08240
gene id: 177437:HRM2_RS08240
uniprot id: C0QAI2
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

177437:HRM2 RS01305
gene id: 177437:HRM2_RS01305
uniprot id: C0QFJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.

177437:HRM2 RS19280
gene id: 177437:HRM2_RS19280
uniprot id: C0QBG5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

177437:HRM2 RS16175
gene id: 177437:HRM2_RS16175
uniprot id: C0QLQ1
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS09475
gene id: 177437:HRM2_RS09475
uniprot id: C0QBZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

177437:HRM2 RS01080
gene id: 177437:HRM2_RS01080
uniprot id: C0QFE9
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

177437:HRM2 RS02025
gene id: 177437:HRM2_RS02025
uniprot id: C0QGQ4
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

177437:HRM2 RS23055
gene id: 177437:HRM2_RS23055
uniprot id: C0QGE3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS17840
gene id: 177437:HRM2_RS17840
uniprot id: C0Q9W1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

177437:HRM2 RS16055
gene id: 177437:HRM2_RS16055
uniprot id: C0QLM7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

177437:HRM2 RS12415
gene id: 177437:HRM2_RS12415
uniprot id: C0QGU2
names: Function
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

177437:HRM2 RS12500
gene id: 177437:HRM2_RS12500
uniprot id: C0QGV9
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

177437:HRM2 RS07910
gene id: 177437:HRM2_RS07910
uniprot id: C0QAB5
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

177437:HRM2 RS06620
gene id: 177437:HRM2_RS06620
uniprot id: C0Q8V3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

177437:HRM2 RS11645
gene id: 177437:HRM2_RS11645
uniprot id: C0QEU8
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

177437:HRM2 RS06780
gene id: 177437:HRM2_RS06780
uniprot id: C0Q8Y3
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS13305
gene id: 177437:HRM2_RS13305
uniprot id: C0QI45
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

177437:HRM2 RS24330
gene id: 177437:HRM2_RS24330
uniprot id: C0QIM4
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

177437:HRM2 RS12365
gene id: 177437:HRM2_RS12365
uniprot id: C0QGT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm
messages: Mitochondrion

177437:HRM2 RS10920
gene id: 177437:HRM2_RS10920
uniprot id: C0QDP0
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 [2Fe-2S] cluster per subunit.

177437:HRM2 RS06295
gene id: 177437:HRM2_RS06295
uniprot id: C0Q8P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

177437:HRM2 RS15430
gene id: 177437:HRM2_RS15430
uniprot id: C0QKW8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS19005
gene id: 177437:HRM2_RS19005
uniprot id: C0QBA9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

177437:HRM2 RS02305
gene id: 177437:HRM2_RS02305
uniprot id: C0QHM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

177437:HRM2 RS23910
gene id: 177437:HRM2_RS23910
uniprot id: C0QID7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Cell outer membrane
messages: Homodimer.
messages: Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.

177437:HRM2 RS25140
gene id: 177437:HRM2_RS25140
uniprot id: C0QCH4
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

177437:HRM2 RS24115
gene id: 177437:HRM2_RS24115
uniprot id: C0QIH8
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS16805
gene id: 177437:HRM2_RS16805
uniprot id: C0QMG2
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

177437:HRM2 RS23355
gene id: 177437:HRM2_RS23355
uniprot id: C0QHB2
names: Similarity
messages: Belongs to the GSP E family.

177437:HRM2 RS21435
gene id: 177437:HRM2_RS21435
uniprot id: C0QDY2
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS00905
gene id: 177437:HRM2_RS00905
uniprot id: C0QFB4
names: Similarity
messages: Belongs to the alkaline phosphatase family.

177437:HRM2 RS10910
gene id: 177437:HRM2_RS10910
uniprot id: C0QDN8
names: Similarity
messages: Belongs to the Ahb/Nir family.

177437:HRM2 RS12565
gene id: 177437:HRM2_RS12565
uniprot id: C0QGX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

177437:HRM2 RS08360
gene id: 177437:HRM2_RS08360
uniprot id: C0QAZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

177437:HRM2 RS08510
gene id: 177437:HRM2_RS08510
uniprot id: C0QB18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

177437:HRM2 RS09320
gene id: 177437:HRM2_RS09320
uniprot id: C0QBV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Periplasm

177437:HRM2 RS21465
gene id: 177437:HRM2_RS21465
uniprot id: C0QDY8
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

177437:HRM2 RS19260
gene id: 177437:HRM2_RS19260
uniprot id: C0QBG1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

177437:HRM2 RS06065
gene id: 177437:HRM2_RS06065
uniprot id: C0QM28
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS18585
gene id: 177437:HRM2_RS18585
uniprot id: C0QAP1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

177437:HRM2 RS21650
gene id: 177437:HRM2_RS21650
uniprot id: C0QE25
names: Similarity
messages: Belongs to the universal stress protein A family.

177437:HRM2 RS00225
gene id: 177437:HRM2_RS00225
uniprot id: C0QE55
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

177437:HRM2 RS15565
gene id: 177437:HRM2_RS15565
uniprot id: C0QKZ5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

177437:HRM2 RS13455
gene id: 177437:HRM2_RS13455
uniprot id: C0QI73
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

177437:HRM2 RS24000
gene id: 177437:HRM2_RS24000
uniprot id: C0QIF5
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS10375
gene id: 177437:HRM2_RS10375
uniprot id: C0QDD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

177437:HRM2 RS01470
gene id: 177437:HRM2_RS01470
uniprot id: C0QFM5
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

177437:HRM2 RS16305
gene id: 177437:HRM2_RS16305
uniprot id: C0QLS4
names: Function
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif.

177437:HRM2 RS05060
gene id: 177437:HRM2_RS05060
uniprot id: C0QL53
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS02635
gene id: 177437:HRM2_RS02635
uniprot id: C0QHT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

177437:HRM2 RS22685
gene id: 177437:HRM2_RS22685
uniprot id: C0QG74
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

177437:HRM2 RS05665
gene id: 177437:HRM2_RS05665
uniprot id: C0QLV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

177437:HRM2 RS09275
gene id: 177437:HRM2_RS09275
uniprot id: C0QBV0
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

177437:HRM2 RS23490
gene id: 177437:HRM2_RS23490
uniprot id: C0QHE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS21290
gene id: 177437:HRM2_RS21290
uniprot id: C0QDV2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

177437:HRM2 RS22335
gene id: 177437:HRM2_RS22335
uniprot id: C0QF84
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

177437:HRM2 RS20080
gene id: 177437:HRM2_RS20080
uniprot id: C0QCB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

177437:HRM2 RS17615
gene id: 177437:HRM2_RS17615
uniprot id: C0Q9C6
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

177437:HRM2 RS06190
gene id: 177437:HRM2_RS06190
uniprot id: C0QM53
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

177437:HRM2 RS07190
gene id: 177437:HRM2_RS07190
uniprot id: C0Q9I8
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

177437:HRM2 RS01240
gene id: 177437:HRM2_RS01240
uniprot id: C0QFI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

177437:HRM2 RS23810
gene id: 177437:HRM2_RS23810
uniprot id: C0QIB8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

177437:HRM2 RS10705
gene id: 177437:HRM2_RS10705
uniprot id: C0QDJ7
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

177437:HRM2 RS20385
gene id: 177437:HRM2_RS20385
uniprot id: C0QCV6
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS12725
gene id: 177437:HRM2_RS12725
uniprot id: C0QH03
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS07645
gene id: 177437:HRM2_RS07645
uniprot id: C0QA61
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

177437:HRM2 RS09245
gene id: 177437:HRM2_RS09245
uniprot id: C0QBU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

177437:HRM2 RS02450
gene id: 177437:HRM2_RS02450
uniprot id: C0QHQ1
names: Similarity
messages: Belongs to the leucine-binding protein family.

177437:HRM2 RS00115
gene id: 177437:HRM2_RS00115
uniprot id: C0QDB1
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

177437:HRM2 RS14430
gene id: 177437:HRM2_RS14430
uniprot id: C0QJY0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS06455
gene id: 177437:HRM2_RS06455
uniprot id: C0Q8S1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

177437:HRM2 RS17610
gene id: 177437:HRM2_RS17610
uniprot id: C0Q9C5
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

177437:HRM2 RS18355
gene id: 177437:HRM2_RS18355
uniprot id: C0QAJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

177437:HRM2 RS17935
gene id: 177437:HRM2_RS17935
uniprot id: C0Q9Y0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

177437:HRM2 RS11225
gene id: 177437:HRM2_RS11225
uniprot id: C0QEL6
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

177437:HRM2 RS12870
gene id: 177437:HRM2_RS12870
uniprot id: C0QH32
names: Subcellular Location Annotation
messages: Cell outer membrane

177437:HRM2 RS18335
gene id: 177437:HRM2_RS18335
uniprot id: C0QAJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

177437:HRM2 RS16470
gene id: 177437:HRM2_RS16470
uniprot id: C0QM95
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS11530
gene id: 177437:HRM2_RS11530
uniprot id: C0QES5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbiQ family.
messages: Membrane

177437:HRM2 RS13555
gene id: 177437:HRM2_RS13555
uniprot id: C0QI93
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

177437:HRM2 RS12755
gene id: 177437:HRM2_RS12755
uniprot id: C0QH09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

177437:HRM2 RS08170
gene id: 177437:HRM2_RS08170
uniprot id: C0QAG9
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

177437:HRM2 RS00515
gene id: 177437:HRM2_RS00515
uniprot id: C0QEB2
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

177437:HRM2 RS01745
gene id: 177437:HRM2_RS01745
uniprot id: C0QGK0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutC family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

177437:HRM2 RS10090
gene id: 177437:HRM2_RS10090
uniprot id: C0QCR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS23620
gene id: 177437:HRM2_RS23620
uniprot id: C0QHG6
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS19735
gene id: 177437:HRM2_RS19735
uniprot id: C0QC44
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS15095
gene id: 177437:HRM2_RS15095
uniprot id: C0QKQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

177437:HRM2 RS11735
gene id: 177437:HRM2_RS11735
uniprot id: C0QFN9
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.

177437:HRM2 RS15060
gene id: 177437:HRM2_RS15060
uniprot id: C0QKP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

177437:HRM2 RS18900
gene id: 177437:HRM2_RS18900
uniprot id: C0QAV5
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS06075
gene id: 177437:HRM2_RS06075
uniprot id: C0QM30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

177437:HRM2 RS01185
gene id: 177437:HRM2_RS01185
uniprot id: C0QFH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

177437:HRM2 RS05005
gene id: 177437:HRM2_RS05005
uniprot id: C0QL41
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

177437:HRM2 RS17270
gene id: 177437:HRM2_RS17270
uniprot id: C0Q964
names: Similarity
messages: Belongs to the proline racemase family.

177437:HRM2 RS04370
gene id: 177437:HRM2_RS04370
uniprot id: C0QKD3
names: Similarity
messages: Belongs to the AAA ATPase family.

177437:HRM2 RS19225
gene id: 177437:HRM2_RS19225
uniprot id: C0QBF4
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS17725
gene id: 177437:HRM2_RS17725
uniprot id: C0Q9T5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

177437:HRM2 RS01090
gene id: 177437:HRM2_RS01090
uniprot id: C0QFF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cob(I)alamin adenosyltransferase family.
messages: Cytoplasm
messages: Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.

177437:HRM2 RS24120
gene id: 177437:HRM2_RS24120
uniprot id: C0QIH9
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS04265
gene id: 177437:HRM2_RS04265
uniprot id: C0QKB1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

177437:HRM2 RS13260
gene id: 177437:HRM2_RS13260
uniprot id: C0QI36
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

177437:HRM2 RS03320
gene id: 177437:HRM2_RS03320
uniprot id: C0QJ09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

177437:HRM2 RS06565
gene id: 177437:HRM2_RS06565
uniprot id: C0Q8U4
names: Similarity
messages: Belongs to the D-alanine--D-alanine ligase family.

177437:HRM2 RS23505
gene id: 177437:HRM2_RS23505
uniprot id: C0QHE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

177437:HRM2 RS14490
gene id: 177437:HRM2_RS14490
uniprot id: C0QJZ3
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

177437:HRM2 RS03305
gene id: 177437:HRM2_RS03305
uniprot id: C0QJ06
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

177437:HRM2 RS25500
gene id: 177437:HRM2_RS25500
uniprot id: C0QAP4
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS06560
gene id: 177437:HRM2_RS06560
uniprot id: C0Q8U3
names: Similarity
messages: Belongs to the histone deacetylase family.

177437:HRM2 RS06260
gene id: 177437:HRM2_RS06260
uniprot id: C0Q8N4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

177437:HRM2 RS24340
gene id: 177437:HRM2_RS24340
uniprot id: C0QIM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS11835
gene id: 177437:HRM2_RS11835
uniprot id: C0QFQ9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

177437:HRM2 RS16075
gene id: 177437:HRM2_RS16075
uniprot id: C0QLN1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

177437:HRM2 RS13505
gene id: 177437:HRM2_RS13505
uniprot id: C0QI83
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

177437:HRM2 RS17895
gene id: 177437:HRM2_RS17895
uniprot id: C0Q9X2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

177437:HRM2 RS06850
gene id: 177437:HRM2_RS06850
uniprot id: C0Q8Z7
names: Similarity
messages: Belongs to the GSP E family.

177437:HRM2 RS13960
gene id: 177437:HRM2_RS13960
uniprot id: C0QJ97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

177437:HRM2 RS01970
gene id: 177437:HRM2_RS01970
uniprot id: C0QGP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

177437:HRM2 RS12395
gene id: 177437:HRM2_RS12395
uniprot id: C0QGT8
names: Similarity
messages: Belongs to the pyruvate kinase family.

177437:HRM2 RS22760
gene id: 177437:HRM2_RS22760
uniprot id: C0QG85
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS21470
gene id: 177437:HRM2_RS21470
uniprot id: C0QDY9
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

177437:HRM2 RS16570
gene id: 177437:HRM2_RS16570
uniprot id: C0QMB5
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS11885
gene id: 177437:HRM2_RS11885
uniprot id: C0QFR9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

177437:HRM2 RS16680
gene id: 177437:HRM2_RS16680
uniprot id: C0QMD7
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS06180
gene id: 177437:HRM2_RS06180
uniprot id: C0QM51
names: Similarity
names: Subunit
messages: Belongs to the threonine aldolase family.
messages: Homotetramer.

177437:HRM2 RS16350
gene id: 177437:HRM2_RS16350
uniprot id: C0QM71
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

177437:HRM2 RS22490
gene id: 177437:HRM2_RS22490
uniprot id: C0QG36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS00605
gene id: 177437:HRM2_RS00605
uniprot id: C0QE55
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

177437:HRM2 RS01540
gene id: 177437:HRM2_RS01540
uniprot id: C0QGG0
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

177437:HRM2 RS01105
gene id: 177437:HRM2_RS01105
uniprot id: C0QFF4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

177437:HRM2 RS00435
gene id: 177437:HRM2_RS00435
uniprot id: C0QE97
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

177437:HRM2 RS25400
gene id: 177437:HRM2_RS25400
uniprot id: C0QLK2
names: Similarity
names: Subunit
messages: Belongs to the RNase H family.
messages: Monomer.

177437:HRM2 RS05460
gene id: 177437:HRM2_RS05460
uniprot id: C0QLD2
names: Similarity
messages: Belongs to the threonine synthase family.

177437:HRM2 RS08990
gene id: 177437:HRM2_RS08990
uniprot id: C0QBA6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

177437:HRM2 RS09200
gene id: 177437:HRM2_RS09200
uniprot id: C0QBT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

177437:HRM2 RS03765
gene id: 177437:HRM2_RS03765
uniprot id: C0QJN2
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

177437:HRM2 RS18330
gene id: 177437:HRM2_RS18330
uniprot id: C0QAJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

177437:HRM2 RS10370
gene id: 177437:HRM2_RS10370
uniprot id: C0QDC9
names: Similarity
messages: Belongs to the universal stress protein A family.

177437:HRM2 RS12275
gene id: 177437:HRM2_RS12275
uniprot id: C0QFZ5
names: Similarity
messages: Belongs to the DapB family.

177437:HRM2 RS07985
gene id: 177437:HRM2_RS07985
uniprot id: C0QAD2
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

177437:HRM2 RS00290
gene id: 177437:HRM2_RS00290
uniprot id: C0QE67
names: Subcellular Location Annotation
messages: Cytoplasm

177437:HRM2 RS10745
gene id: 177437:HRM2_RS10745
uniprot id: C0QDK5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

177437:HRM2 RS04955
gene id: 177437:HRM2_RS04955
uniprot id: C0QL31
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

177437:HRM2 RS22695
gene id: 177437:HRM2_RS22695
uniprot id: C0QG75
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS20010
gene id: 177437:HRM2_RS20010
uniprot id: C0QC98
names: Similarity
messages: Belongs to the phosphohexose mutase family.

177437:HRM2 RS18020
gene id: 177437:HRM2_RS18020
uniprot id: C0Q9Z3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

177437:HRM2 RS12035
gene id: 177437:HRM2_RS12035
uniprot id: C0QFU6
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS06845
gene id: 177437:HRM2_RS06845
uniprot id: C0Q8Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

177437:HRM2 RS22105
gene id: 177437:HRM2_RS22105
uniprot id: C0QF40
names: Similarity
messages: Belongs to the CFA/CMAS family.

177437:HRM2 RS15675
gene id: 177437:HRM2_RS15675
uniprot id: C0QLF2
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

177437:HRM2 RS08450
gene id: 177437:HRM2_RS08450
uniprot id: C0QB07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

177437:HRM2 RS12545
gene id: 177437:HRM2_RS12545
uniprot id: C0QGW8
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

177437:HRM2 RS03815
gene id: 177437:HRM2_RS03815
uniprot id: C0QJP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

177437:HRM2 RS06095
gene id: 177437:HRM2_RS06095
uniprot id: C0QM34
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

177437:HRM2 RS09380
gene id: 177437:HRM2_RS09380
uniprot id: C0QBX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

177437:HRM2 RS19050
gene id: 177437:HRM2_RS19050
uniprot id: C0QBB8
names: Similarity
messages: Belongs to the AOR/FOR family.

177437:HRM2 RS23935
gene id: 177437:HRM2_RS23935
uniprot id: C0QIE2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

177437:HRM2 RS08845
gene id: 177437:HRM2_RS08845
uniprot id: C0QB80
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS18925
gene id: 177437:HRM2_RS18925
uniprot id: C0QAW0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS22485
gene id: 177437:HRM2_RS22485
uniprot id: C0QG35
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS14505
gene id: 177437:HRM2_RS14505
uniprot id: C0QJZ6
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

177437:HRM2 RS17800
gene id: 177437:HRM2_RS17800
uniprot id: C0Q9V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

177437:HRM2 RS18080
gene id: 177437:HRM2_RS18080
uniprot id: C0QA05
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

177437:HRM2 RS04515
gene id: 177437:HRM2_RS04515
uniprot id: C0QKG2
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

177437:HRM2 RS13770
gene id: 177437:HRM2_RS13770
uniprot id: C0QJ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

177437:HRM2 RS21530
gene id: 177437:HRM2_RS21530
uniprot id: C0QE01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS11545
gene id: 177437:HRM2_RS11545
uniprot id: C0QES8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS02550
gene id: 177437:HRM2_RS02550
uniprot id: C0QHS1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

177437:HRM2 RS11150
gene id: 177437:HRM2_RS11150
uniprot id: C0QEK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

177437:HRM2 RS09755
gene id: 177437:HRM2_RS09755
uniprot id: C0QCJ1
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS18225
gene id: 177437:HRM2_RS18225
uniprot id: C0QA34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

177437:HRM2 RS00440
gene id: 177437:HRM2_RS00440
uniprot id: C0QE98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

177437:HRM2 RS20785
gene id: 177437:HRM2_RS20785
uniprot id: C0QD43
names: Similarity
messages: Belongs to the PspA/IM30 family.

177437:HRM2 RS22600
gene id: 177437:HRM2_RS22600
uniprot id: C0QG58
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS12375
gene id: 177437:HRM2_RS12375
uniprot id: C0QGT4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

177437:HRM2 RS14700
gene id: 177437:HRM2_RS14700
uniprot id: C0QK33
names: Similarity
messages: Belongs to the polysaccharide synthase family.

177437:HRM2 RS08840
gene id: 177437:HRM2_RS08840
uniprot id: C0QB79
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS10145
gene id: 177437:HRM2_RS10145
uniprot id: C0QCR9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

177437:HRM2 RS04140
gene id: 177437:HRM2_RS04140
uniprot id: C0QJV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS07585
gene id: 177437:HRM2_RS07585
uniprot id: C0Q9S0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

177437:HRM2 RS05040
gene id: 177437:HRM2_RS05040
uniprot id: C0QL48
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

177437:HRM2 RS10735
gene id: 177437:HRM2_RS10735
uniprot id: C0QDK3
names: Similarity
messages: Belongs to the RecJ family.

177437:HRM2 RS19685
gene id: 177437:HRM2_RS19685
uniprot id: C0QC34
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

177437:HRM2 RS17250
gene id: 177437:HRM2_RS17250
uniprot id: C0Q960
names: Subunit
messages: Heterodimer of a large and a small subunit.

177437:HRM2 RS10425
gene id: 177437:HRM2_RS10425
uniprot id: C0QDE1
names: Caution
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS04290
gene id: 177437:HRM2_RS04290
uniprot id: C0QKB6
names: Caution
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS07640
gene id: 177437:HRM2_RS07640
uniprot id: C0QA60
names: Function
names: Similarity
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

177437:HRM2 RS07275
gene id: 177437:HRM2_RS07275
uniprot id: C0Q9K2
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

177437:HRM2 RS13800
gene id: 177437:HRM2_RS13800
uniprot id: C0QJ65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

177437:HRM2 RS02125
gene id: 177437:HRM2_RS02125
uniprot id: C0QGS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS05515
gene id: 177437:HRM2_RS05515
uniprot id: C0QLE3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

177437:HRM2 RS23590
gene id: 177437:HRM2_RS23590
uniprot id: C0QHG0
names: Similarity
messages: Belongs to the FGGY kinase family.

177437:HRM2 RS13220
gene id: 177437:HRM2_RS13220
uniprot id: C0QI28
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

177437:HRM2 RS03365
gene id: 177437:HRM2_RS03365
uniprot id: C0QJ18
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrC family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

177437:HRM2 RS00645
gene id: 177437:HRM2_RS00645
uniprot id: C0QEE2
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS02280
gene id: 177437:HRM2_RS02280
uniprot id: C0QHL9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

177437:HRM2 RS21010
gene id: 177437:HRM2_RS21010
uniprot id: C0QDP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

177437:HRM2 RS13725
gene id: 177437:HRM2_RS13725
uniprot id: C0QJ50
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS12285
gene id: 177437:HRM2_RS12285
uniprot id: C0QFZ7
names: Similarity
messages: Belongs to the GPAT/DAPAT family.

177437:HRM2 RS18960
gene id: 177437:HRM2_RS18960
uniprot id: C0QAW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

177437:HRM2 RS18555
gene id: 177437:HRM2_RS18555
uniprot id: C0QAN5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS03245
gene id: 177437:HRM2_RS03245
uniprot id: C0QIZ4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

177437:HRM2 RS04350
gene id: 177437:HRM2_RS04350
uniprot id: C0QKC8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

177437:HRM2 RS00090
gene id: 177437:HRM2_RS00090
uniprot id: C0QDA5
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

177437:HRM2 RS13525
gene id: 177437:HRM2_RS13525
uniprot id: C0QI87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS18460
gene id: 177437:HRM2_RS18460
uniprot id: C0QAL6
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

177437:HRM2 RS12195
gene id: 177437:HRM2_RS12195
uniprot id: C0QFX9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS17340
gene id: 177437:HRM2_RS17340
uniprot id: C0Q974
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

177437:HRM2 RS02585
gene id: 177437:HRM2_RS02585
uniprot id: C0QHS8
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

177437:HRM2 RS05300
gene id: 177437:HRM2_RS05300
uniprot id: C0QLA1
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

177437:HRM2 RS12330
gene id: 177437:HRM2_RS12330
uniprot id: C0QG06
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

177437:HRM2 RS19040
gene id: 177437:HRM2_RS19040
uniprot id: C0QBB6
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

177437:HRM2 RS10750
gene id: 177437:HRM2_RS10750
uniprot id: C0QDK6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

177437:HRM2 RS13660
gene id: 177437:HRM2_RS13660
uniprot id: C0QJ37
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

177437:HRM2 RS23410
gene id: 177437:HRM2_RS23410
uniprot id: C0QHC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

177437:HRM2 RS05730
gene id: 177437:HRM2_RS05730
uniprot id: C0QLW5
names: Similarity
messages: Belongs to the HupF/HypC family.

177437:HRM2 RS19095
gene id: 177437:HRM2_RS19095
uniprot id: C0QBC6
names: Similarity
messages: Belongs to the AOR/FOR family.

177437:HRM2 RS02315
gene id: 177437:HRM2_RS02315
uniprot id: C0QHM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

177437:HRM2 RS07780
gene id: 177437:HRM2_RS07780
uniprot id: C0QA86
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

177437:HRM2 RS04160
gene id: 177437:HRM2_RS04160
uniprot id: C0QK90
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

177437:HRM2 RS08740
gene id: 177437:HRM2_RS08740
uniprot id: C0QB60
names: Similarity
messages: Belongs to the PspA/IM30 family.

177437:HRM2 RS07330
gene id: 177437:HRM2_RS07330
uniprot id: C0Q9L4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

177437:HRM2 RS09800
gene id: 177437:HRM2_RS09800
uniprot id: C0QCK1
names: Similarity
messages: Belongs to the HepT RNase toxin family.

177437:HRM2 RS14530
gene id: 177437:HRM2_RS14530
uniprot id: C0QK00
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

177437:HRM2 RS03435
gene id: 177437:HRM2_RS03435
uniprot id: C0QJ32
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.

177437:HRM2 RS14635
gene id: 177437:HRM2_RS14635
uniprot id: C0QK22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS15950
gene id: 177437:HRM2_RS15950
uniprot id: C0QLK7
names: Similarity
messages: Belongs to the UPF0251 family.

177437:HRM2 RS18485
gene id: 177437:HRM2_RS18485
uniprot id: C0QAM1
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS03655
gene id: 177437:HRM2_RS03655
uniprot id: C0QJL0
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS14000
gene id: 177437:HRM2_RS14000
uniprot id: C0QJA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell inner membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

177437:HRM2 RS11345
gene id: 177437:HRM2_RS11345
uniprot id: C0QEN9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
messages: Membrane

177437:HRM2 RS12245
gene id: 177437:HRM2_RS12245
uniprot id: C0QFY9
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

177437:HRM2 RS25210
gene id: 177437:HRM2_RS25210
uniprot id: C0QFU3
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS01355
gene id: 177437:HRM2_RS01355
uniprot id: C0QFK3
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS21445
gene id: 177437:HRM2_RS21445
uniprot id: C0QDY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

177437:HRM2 RS12250
gene id: 177437:HRM2_RS12250
uniprot id: C0QFZ0
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

177437:HRM2 RS04190
gene id: 177437:HRM2_RS04190
uniprot id: C0QK96
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

177437:HRM2 RS13655
gene id: 177437:HRM2_RS13655
uniprot id: C0QJ36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

177437:HRM2 RS18380
gene id: 177437:HRM2_RS18380
uniprot id: C0QAK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS06435
gene id: 177437:HRM2_RS06435
uniprot id: C0Q8R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Membrane

177437:HRM2 RS14090
gene id: 177437:HRM2_RS14090
uniprot id: C0QJC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Periplasm
messages: Secreted

177437:HRM2 RS13480
gene id: 177437:HRM2_RS13480
uniprot id: C0QI78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

177437:HRM2 RS19940
gene id: 177437:HRM2_RS19940
uniprot id: C0QC85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell inner membrane
messages: Probably functions as a manganese efflux pump.

177437:HRM2 RS13850
gene id: 177437:HRM2_RS13850
uniprot id: C0QJ75
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

177437:HRM2 RS04560
gene id: 177437:HRM2_RS04560
uniprot id: C0QKH1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

177437:HRM2 RS13275
gene id: 177437:HRM2_RS13275
uniprot id: C0QI39
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS20085
gene id: 177437:HRM2_RS20085
uniprot id: C0QCB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

177437:HRM2 RS11595
gene id: 177437:HRM2_RS11595
uniprot id: C0QET8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase Slt family.
messages: Cell outer membrane
messages: Membrane

177437:HRM2 RS02730
gene id: 177437:HRM2_RS02730
uniprot id: C0QHV8
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

177437:HRM2 RS14095
gene id: 177437:HRM2_RS14095
uniprot id: C0QJC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS06285
gene id: 177437:HRM2_RS06285
uniprot id: C0Q8N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

177437:HRM2 RS03335
gene id: 177437:HRM2_RS03335
uniprot id: C0QJ12
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

177437:HRM2 RS05660
gene id: 177437:HRM2_RS05660
uniprot id: C0QLV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

177437:HRM2 RS04915
gene id: 177437:HRM2_RS04915
uniprot id: C0QL23
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

177437:HRM2 RS04830
gene id: 177437:HRM2_RS04830
uniprot id: C0QKM2
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.
messages: Binds 1 zinc ion per subunit.

177437:HRM2 RS10645
gene id: 177437:HRM2_RS10645
uniprot id: C0QDI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS18310
gene id: 177437:HRM2_RS18310
uniprot id: C0QA51
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

177437:HRM2 RS00975
gene id: 177437:HRM2_RS00975
uniprot id: C0QFC8
names: Similarity
messages: Belongs to the AOR/FOR family.

177437:HRM2 RS20965
gene id: 177437:HRM2_RS20965
uniprot id: C0QD78
names: Similarity
messages: Belongs to the UDPGP type 2 family.

177437:HRM2 RS00660
gene id: 177437:HRM2_RS00660
uniprot id: C0QEE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine.
messages: Cytoplasm
messages: Homodimer.

177437:HRM2 RS11480
gene id: 177437:HRM2_RS11480
uniprot id: C0QER5
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

177437:HRM2 RS22425
gene id: 177437:HRM2_RS22425
uniprot id: C0QG24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS23085
gene id: 177437:HRM2_RS23085
uniprot id: C0QH69
names: Similarity
messages: Belongs to the YciI family.

177437:HRM2 RS12700
gene id: 177437:HRM2_RS12700
uniprot id: C0QGZ8
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS13180
gene id: 177437:HRM2_RS13180
uniprot id: C0QI20
names: Similarity
messages: Belongs to the CinA family.

177437:HRM2 RS01950
gene id: 177437:HRM2_RS01950
uniprot id: C0QGN9
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS10970
gene id: 177437:HRM2_RS10970
uniprot id: C0QEH0
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

177437:HRM2 RS21680
gene id: 177437:HRM2_RS21680
uniprot id: C0QE32
names: Cofactor
messages: Binds 1 zinc ion per subunit.

177437:HRM2 RS04135
gene id: 177437:HRM2_RS04135
uniprot id: C0QJV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS06305
gene id: 177437:HRM2_RS06305
uniprot id: C0Q8P3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS11715
gene id: 177437:HRM2_RS11715
uniprot id: C0QFN5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

177437:HRM2 RS17280
gene id: 177437:HRM2_RS17280
uniprot id: C0Q966
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS00325
gene id: 177437:HRM2_RS00325
uniprot id: C0QE74
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

177437:HRM2 RS12010
gene id: 177437:HRM2_RS12010
uniprot id: C0QFU1
names: Subcellular Location Annotation
messages: Cytoplasm

177437:HRM2 RS10365
gene id: 177437:HRM2_RS10365
uniprot id: C0QDC8
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

177437:HRM2 RS10675
gene id: 177437:HRM2_RS10675
uniprot id: C0QDJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS08520
gene id: 177437:HRM2_RS08520
uniprot id: C0QB20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

177437:HRM2 RS07140
gene id: 177437:HRM2_RS07140
uniprot id: C0Q9H8
names: Similarity
messages: Belongs to the HdrA family.

177437:HRM2 RS02205
gene id: 177437:HRM2_RS02205
uniprot id: C0QHK4
names: Subcellular Location Annotation
messages: Cytoplasm

177437:HRM2 RS20315
gene id: 177437:HRM2_RS20315
uniprot id: C0QCF6
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

177437:HRM2 RS15445
gene id: 177437:HRM2_RS15445
uniprot id: C0QKX1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

177437:HRM2 RS14240
gene id: 177437:HRM2_RS14240
uniprot id: C0QJF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

177437:HRM2 RS22470
gene id: 177437:HRM2_RS22470
uniprot id: C0QG33
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS17200
gene id: 177437:HRM2_RS17200
uniprot id: C0Q955
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

177437:HRM2 RS09125
gene id: 177437:HRM2_RS09125
uniprot id: C0QBS1
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS10395
gene id: 177437:HRM2_RS10395
uniprot id: C0QDD4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS12660
gene id: 177437:HRM2_RS12660
uniprot id: C0QGZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

177437:HRM2 RS17640
gene id: 177437:HRM2_RS17640
uniprot id: C0Q9D1
names: Function
names: Similarity
messages: Belongs to the FlgM family.
messages: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

177437:HRM2 RS09130
gene id: 177437:HRM2_RS09130
uniprot id: C0QBS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS27350
gene id: 177437:HRM2_RS27350
uniprot id: C0QKK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

177437:HRM2 RS21065
gene id: 177437:HRM2_RS21065
uniprot id: C0QDQ9
names: Function
names: Similarity
messages: Belongs to the DtxR/MntR family.
messages: In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP.

177437:HRM2 RS00395
gene id: 177437:HRM2_RS00395
uniprot id: C0QE89
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

177437:HRM2 RS23925
gene id: 177437:HRM2_RS23925
uniprot id: C0QIE0
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

177437:HRM2 RS19165
gene id: 177437:HRM2_RS19165
uniprot id: C0QBE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS10010
gene id: 177437:HRM2_RS10010
uniprot id: C0QCP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

177437:HRM2 RS22165
gene id: 177437:HRM2_RS22165
uniprot id: C0QF51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

177437:HRM2 RS05585
gene id: 177437:HRM2_RS05585
uniprot id: C0QLT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family. GSP D subfamily.
messages: Cell outer membrane

177437:HRM2 RS18965
gene id: 177437:HRM2_RS18965
uniprot id: C0QAX0
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

177437:HRM2 RS15555
gene id: 177437:HRM2_RS15555
uniprot id: C0QKZ3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

177437:HRM2 RS15420
gene id: 177437:HRM2_RS15420
uniprot id: C0QKW6
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

177437:HRM2 RS25015
gene id: 177437:HRM2_RS25015
uniprot id: C0Q9H7
names: Subunit
messages: Heterodimer of a large and a small subunit.

177437:HRM2 RS10995
gene id: 177437:HRM2_RS10995
uniprot id: C0QEH5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

177437:HRM2 RS02290
gene id: 177437:HRM2_RS02290
uniprot id: C0QHM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

177437:HRM2 RS04565
gene id: 177437:HRM2_RS04565
uniprot id: C0QKH2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Belongs to the GARS family.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

177437:HRM2 RS02695
gene id: 177437:HRM2_RS02695
uniprot id: C0QHV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

177437:HRM2 RS12410
gene id: 177437:HRM2_RS12410
uniprot id: C0QGU1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

177437:HRM2 RS08515
gene id: 177437:HRM2_RS08515
uniprot id: C0QB19
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.

177437:HRM2 RS09295
gene id: 177437:HRM2_RS09295
uniprot id: C0QBV4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

177437:HRM2 RS05610
gene id: 177437:HRM2_RS05610
uniprot id: C0QLU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

177437:HRM2 RS13540
gene id: 177437:HRM2_RS13540
uniprot id: C0QI90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

177437:HRM2 RS24960
gene id: 177437:HRM2_RS24960
uniprot id: C0QJU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

177437:HRM2 RS17390
gene id: 177437:HRM2_RS17390
uniprot id: C0Q983
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase B chain family.
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Membrane

177437:HRM2 RS16015
gene id: 177437:HRM2_RS16015
uniprot id: C0QLM0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

177437:HRM2 RS04950
gene id: 177437:HRM2_RS04950
uniprot id: C0QL30
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

177437:HRM2 RS02445
gene id: 177437:HRM2_RS02445
uniprot id: C0QHQ0
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS22400
gene id: 177437:HRM2_RS22400
uniprot id: C0QG19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS09230
gene id: 177437:HRM2_RS09230
uniprot id: C0QBU1
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

177437:HRM2 RS11805
gene id: 177437:HRM2_RS11805
uniprot id: C0QFQ3
names: Similarity
messages: Belongs to the universal stress protein A family.

177437:HRM2 RS14995
gene id: 177437:HRM2_RS14995
uniprot id: C0QKN1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

177437:HRM2 RS21740
gene id: 177437:HRM2_RS21740
uniprot id: C0QEW3
names: Similarity
messages: Belongs to the AOR/FOR family.

177437:HRM2 RS17805
gene id: 177437:HRM2_RS17805
uniprot id: C0Q9V3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

177437:HRM2 RS11640
gene id: 177437:HRM2_RS11640
uniprot id: C0QEU7
names: Similarity
messages: Belongs to the peptidase S16 family.

177437:HRM2 RS14245
gene id: 177437:HRM2_RS14245
uniprot id: C0QJF7
names: Similarity
messages: Belongs to the histone deacetylase family.

177437:HRM2 RS05630
gene id: 177437:HRM2_RS05630
uniprot id: C0QLU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

177437:HRM2 RS24440
gene id: 177437:HRM2_RS24440
uniprot id: C0QIP6
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS06635
gene id: 177437:HRM2_RS06635
uniprot id: C0Q8V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

177437:HRM2 RS21225
gene id: 177437:HRM2_RS21225
uniprot id: C0QDU1
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

177437:HRM2 RS05230
gene id: 177437:HRM2_RS05230
uniprot id: C0QL87
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

177437:HRM2 RS15380
gene id: 177437:HRM2_RS15380
uniprot id: C0QKV8
names: Similarity
messages: Belongs to the histone deacetylase family.

177437:HRM2 RS18595
gene id: 177437:HRM2_RS18595
uniprot id: C0QAP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

177437:HRM2 RS01030
gene id: 177437:HRM2_RS01030
uniprot id: C0QFE0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

177437:HRM2 RS02385
gene id: 177437:HRM2_RS02385
uniprot id: C0QHN9
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

177437:HRM2 RS12945
gene id: 177437:HRM2_RS12945
uniprot id: C0QH53
names: Similarity
messages: Belongs to the peptidase S45 family.

177437:HRM2 RS15105
gene id: 177437:HRM2_RS15105
uniprot id: C0QKQ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

177437:HRM2 RS08425
gene id: 177437:HRM2_RS08425
uniprot id: C0QB02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

177437:HRM2 RS05135
gene id: 177437:HRM2_RS05135
uniprot id: C0QL67
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

177437:HRM2 RS05935
gene id: 177437:HRM2_RS05935
uniprot id: C0QM04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

177437:HRM2 RS21515
gene id: 177437:HRM2_RS21515
uniprot id: C0QDZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

177437:HRM2 RS08300
gene id: 177437:HRM2_RS08300
uniprot id: C0QAY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

177437:HRM2 RS23225
gene id: 177437:HRM2_RS23225
uniprot id: C0QH94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

177437:HRM2 RS08910
gene id: 177437:HRM2_RS08910
uniprot id: C0QB93
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

177437:HRM2 RS18400
gene id: 177437:HRM2_RS18400
uniprot id: C0QAK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

177437:HRM2 RS11585
gene id: 177437:HRM2_RS11585
uniprot id: C0QET6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

177437:HRM2 RS08180
gene id: 177437:HRM2_RS08180
uniprot id: C0QAH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

177437:HRM2 RS11825
gene id: 177437:HRM2_RS11825
uniprot id: C0QFQ7
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS00045
gene id: 177437:HRM2_RS00045
uniprot id: C0QD94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Cytoplasm

177437:HRM2 RS17670
gene id: 177437:HRM2_RS17670
uniprot id: C0Q9D7
names: Similarity
messages: Belongs to the PhoH family.

177437:HRM2 RS19680
gene id: 177437:HRM2_RS19680
uniprot id: C0QC33
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

177437:HRM2 RS07620
gene id: 177437:HRM2_RS07620
uniprot id: C0QA56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS03865
gene id: 177437:HRM2_RS03865
uniprot id: C0QJQ0
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS17555
gene id: 177437:HRM2_RS17555
uniprot id: C0Q9B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

177437:HRM2 RS24890
gene id: 177437:HRM2_RS24890
uniprot id: C0QIT8
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

177437:HRM2 RS03315
gene id: 177437:HRM2_RS03315
uniprot id: C0QJ08
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

177437:HRM2 RS00710
gene id: 177437:HRM2_RS00710
uniprot id: C0QEF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

177437:HRM2 RS18265
gene id: 177437:HRM2_RS18265
uniprot id: C0QA42
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

177437:HRM2 RS08505
gene id: 177437:HRM2_RS08505
uniprot id: C0QB17
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

177437:HRM2 RS15230
gene id: 177437:HRM2_RS15230
uniprot id: C0QKS9
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

177437:HRM2 RS20015
gene id: 177437:HRM2_RS20015
uniprot id: C0QC99
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane

177437:HRM2 RS06460
gene id: 177437:HRM2_RS06460
uniprot id: C0Q8S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

177437:HRM2 RS19675
gene id: 177437:HRM2_RS19675
uniprot id: C0QC32
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

177437:HRM2 RS01380
gene id: 177437:HRM2_RS01380
uniprot id: C0QFK8
names: Similarity
messages: Belongs to the UPF0597 family.

177437:HRM2 RS02980
gene id: 177437:HRM2_RS02980
uniprot id: C0QIT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell inner membrane
messages: Membrane

177437:HRM2 RS15605
gene id: 177437:HRM2_RS15605
uniprot id: C0QL01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

177437:HRM2 RS03840
gene id: 177437:HRM2_RS03840
uniprot id: C0QJP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

177437:HRM2 RS06290
gene id: 177437:HRM2_RS06290
uniprot id: C0Q8P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane

177437:HRM2 RS17765
gene id: 177437:HRM2_RS17765
uniprot id: C0Q9U4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

177437:HRM2 RS23830
gene id: 177437:HRM2_RS23830
uniprot id: C0QIC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS11200
gene id: 177437:HRM2_RS11200
uniprot id: C0QEL1
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

177437:HRM2 RS18110
gene id: 177437:HRM2_RS18110
uniprot id: C0QA09
names: Similarity
messages: Belongs to the MotB family.

177437:HRM2 RS18115
gene id: 177437:HRM2_RS18115
uniprot id: C0QA11
names: Similarity
messages: Belongs to the polysaccharide synthase family.

177437:HRM2 RS02155
gene id: 177437:HRM2_RS02155
uniprot id: C0QGS9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

177437:HRM2 RS12305
gene id: 177437:HRM2_RS12305
uniprot id: C0QG01
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

177437:HRM2 RS01710
gene id: 177437:HRM2_RS01710
uniprot id: C0QGJ3
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

177437:HRM2 RS14475
gene id: 177437:HRM2_RS14475
uniprot id: C0QJY9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

177437:HRM2 RS15850
gene id: 177437:HRM2_RS15850
uniprot id: C0QLI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

177437:HRM2 RS12820
gene id: 177437:HRM2_RS12820
uniprot id: C0QH22
names: Similarity
messages: Belongs to the SAICAR synthetase family.

177437:HRM2 RS15685
gene id: 177437:HRM2_RS15685
uniprot id: C0QLF4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

177437:HRM2 RS16455
gene id: 177437:HRM2_RS16455
uniprot id: C0QM91
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

177437:HRM2 RS08680
gene id: 177437:HRM2_RS08680
uniprot id: C0QB48
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

177437:HRM2 RS14565
gene id: 177437:HRM2_RS14565
uniprot id: C0QK08
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

177437:HRM2 RS00035
gene id: 177437:HRM2_RS00035
uniprot id: C0QD92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

177437:HRM2 RS12765
gene id: 177437:HRM2_RS12765
uniprot id: C0QH11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

177437:HRM2 RS03080
gene id: 177437:HRM2_RS03080
uniprot id: C0QIV7
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS00700
gene id: 177437:HRM2_RS00700
uniprot id: C0QEF3
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS13290
gene id: 177437:HRM2_RS13290
uniprot id: C0QI42
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS07335
gene id: 177437:HRM2_RS07335
uniprot id: C0Q9L5
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

177437:HRM2 RS11955
gene id: 177437:HRM2_RS11955
uniprot id: C0QFT2
names: Similarity
messages: Belongs to the PspA/IM30 family.

177437:HRM2 RS06330
gene id: 177437:HRM2_RS06330
uniprot id: C0Q8P8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

177437:HRM2 RS21295
gene id: 177437:HRM2_RS21295
uniprot id: C0QDV3
names: Similarity
messages: Belongs to the IMPACT family.

177437:HRM2 RS04430
gene id: 177437:HRM2_RS04430
uniprot id: C0QKE4
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

177437:HRM2 RS15510
gene id: 177437:HRM2_RS15510
uniprot id: C0QKY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

177437:HRM2 RS00420
gene id: 177437:HRM2_RS00420
uniprot id: C0QE94
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the NapC/NirT/NrfH family.
messages: Binds 4 heme groups per subunit.

177437:HRM2 RS20145
gene id: 177437:HRM2_RS20145
uniprot id: C0QCC5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

177437:HRM2 RS14300
gene id: 177437:HRM2_RS14300
uniprot id: C0QJG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
messages: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
messages: Homodimer.

177437:HRM2 RS13210
gene id: 177437:HRM2_RS13210
uniprot id: C0QI26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

177437:HRM2 RS18195
gene id: 177437:HRM2_RS18195
uniprot id: C0QA28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

177437:HRM2 RS14675
gene id: 177437:HRM2_RS14675
uniprot id: C0QK27
names: Similarity
messages: Belongs to the heat shock protein 70 family.

177437:HRM2 RS02355
gene id: 177437:HRM2_RS02355
uniprot id: C0QHN3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

177437:HRM2 RS05545
gene id: 177437:HRM2_RS05545
uniprot id: C0QLS9
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

177437:HRM2 RS03775
gene id: 177437:HRM2_RS03775
uniprot id: C0QJN4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

177437:HRM2 RS18940
gene id: 177437:HRM2_RS18940
uniprot id: C0QAW4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

177437:HRM2 RS18525
gene id: 177437:HRM2_RS18525
uniprot id: C0QAM9
names: Similarity
messages: Belongs to the thioesterase PaaI family.

177437:HRM2 RS08540
gene id: 177437:HRM2_RS08540
uniprot id: C0QB24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

177437:HRM2 RS22940
gene id: 177437:HRM2_RS22940
uniprot id: C0QGB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS01990
gene id: 177437:HRM2_RS01990
uniprot id: C0QGP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

177437:HRM2 RS15010
gene id: 177437:HRM2_RS15010
uniprot id: C0QKN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

177437:HRM2 RS15865
gene id: 177437:HRM2_RS15865
uniprot id: C0QLJ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

177437:HRM2 RS18920
gene id: 177437:HRM2_RS18920
uniprot id: C0QAV9
names: Similarity
messages: Belongs to the universal stress protein A family.

177437:HRM2 RS08085
gene id: 177437:HRM2_RS08085
uniprot id: C0QAF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

177437:HRM2 RS15475
gene id: 177437:HRM2_RS15475
uniprot id: C0QKX7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

177437:HRM2 RS19070
gene id: 177437:HRM2_RS19070
uniprot id: C0QBA9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

177437:HRM2 RS05445
gene id: 177437:HRM2_RS05445
uniprot id: C0QLC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family.
messages: Cell outer membrane

177437:HRM2 RS17135
gene id: 177437:HRM2_RS17135
uniprot id: C0Q941
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.
messages: Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids.

177437:HRM2 RS11285
gene id: 177437:HRM2_RS11285
uniprot id: C0QEM8
names: Similarity
messages: Belongs to the HdrA family.

177437:HRM2 RS15505
gene id: 177437:HRM2_RS15505
uniprot id: C0QKY2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

177437:HRM2 RS17720
gene id: 177437:HRM2_RS17720
uniprot id: C0Q9T4
names: Similarity
messages: Belongs to the aspartokinase family.

177437:HRM2 RS11120
gene id: 177437:HRM2_RS11120
uniprot id: C0QEK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

177437:HRM2 RS20340
gene id: 177437:HRM2_RS20340
uniprot id: C0QCG2
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

177437:HRM2 RS19100
gene id: 177437:HRM2_RS19100
uniprot id: C0QBC7
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

177437:HRM2 RS15110
gene id: 177437:HRM2_RS15110
uniprot id: C0QKQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

177437:HRM2 RS12940
gene id: 177437:HRM2_RS12940
uniprot id: C0QH52
names: Similarity
messages: Belongs to the RNase T2 family.

177437:HRM2 RS13450
gene id: 177437:HRM2_RS13450
uniprot id: C0QI72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

177437:HRM2 RS14690
gene id: 177437:HRM2_RS14690
uniprot id: C0QK31
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

177437:HRM2 RS05495
gene id: 177437:HRM2_RS05495
uniprot id: C0QLD9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

177437:HRM2 RS09270
gene id: 177437:HRM2_RS09270
uniprot id: C0QBU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

177437:HRM2 RS15270
gene id: 177437:HRM2_RS15270
uniprot id: C0QKT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

177437:HRM2 RS04925
gene id: 177437:HRM2_RS04925
uniprot id: C0QL25
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

177437:HRM2 RS07130
gene id: 177437:HRM2_RS07130
uniprot id: C0Q9H6
names: Similarity
messages: Belongs to the AOR/FOR family.

177437:HRM2 RS19900
gene id: 177437:HRM2_RS19900
uniprot id: C0QC77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

177437:HRM2 RS25370
gene id: 177437:HRM2_RS25370
uniprot id: C0QKP3
names: Similarity
messages: Belongs to the YkuD family.

177437:HRM2 RS06140
gene id: 177437:HRM2_RS06140
uniprot id: C0QM43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

177437:HRM2 RS00210
gene id: 177437:HRM2_RS00210
uniprot id: C0QE52
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

177437:HRM2 RS05685
gene id: 177437:HRM2_RS05685
uniprot id: C0QLV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

177437:HRM2 RS05785
gene id: 177437:HRM2_RS05785
uniprot id: C0QLX6
names: Similarity
messages: Belongs to the peptidase A31 family.

177437:HRM2 RS08810
gene id: 177437:HRM2_RS08810
uniprot id: C0QB74
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS18970
gene id: 177437:HRM2_RS18970
uniprot id: C0QAX1
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

177437:HRM2 RS24445
gene id: 177437:HRM2_RS24445
uniprot id: C0QIP7
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

177437:HRM2 RS02475
gene id: 177437:HRM2_RS02475
uniprot id: C0QHQ6
names: Similarity
messages: Belongs to the GSP E family.

177437:HRM2 RS01545
gene id: 177437:HRM2_RS01545
uniprot id: C0QGG1
names: Cofactor
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

177437:HRM2 RS17950
gene id: 177437:HRM2_RS17950
uniprot id: C0Q9Y3
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

177437:HRM2 RS12775
gene id: 177437:HRM2_RS12775
uniprot id: C0QH13
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

177437:HRM2 RS16250
gene id: 177437:HRM2_RS16250
uniprot id: C0QLR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

177437:HRM2 RS15640
gene id: 177437:HRM2_RS15640
uniprot id: C0QL09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

177437:HRM2 RS17955
gene id: 177437:HRM2_RS17955
uniprot id: C0Q9Y4
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

177437:HRM2 RS21745
gene id: 177437:HRM2_RS21745
uniprot id: C0QEW4
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

177437:HRM2 RS16995
gene id: 177437:HRM2_RS16995
uniprot id: C0QMJ9
names: Similarity
messages: Belongs to the hemerythrin family.

177437:HRM2 RS22765
gene id: 177437:HRM2_RS22765
uniprot id: C0QG86
names: Similarity
messages: Belongs to the AlaDH/PNT family.

177437:HRM2 RS17845
gene id: 177437:HRM2_RS17845
uniprot id: C0Q9W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

177437:HRM2 RS18795
gene id: 177437:HRM2_RS18795
uniprot id: C0QAT5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

177437:HRM2 RS15985
gene id: 177437:HRM2_RS15985
uniprot id: C0QLL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial glucokinase family.
messages: Cytoplasm

177437:HRM2 RS15100
gene id: 177437:HRM2_RS15100
uniprot id: C0QKQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

177437:HRM2 RS06310
gene id: 177437:HRM2_RS06310
uniprot id: C0Q8P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

177437:HRM2 RS16000
gene id: 177437:HRM2_RS16000
uniprot id: C0QLL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane

177437:HRM2 RS09405
gene id: 177437:HRM2_RS09405
uniprot id: C0QBX6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

177437:HRM2 RS03770
gene id: 177437:HRM2_RS03770
uniprot id: C0QJN3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

177437:HRM2 RS13935
gene id: 177437:HRM2_RS13935
uniprot id: C0QJ92
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

177437:HRM2 RS16120
gene id: 177437:HRM2_RS16120
uniprot id: C0QLP0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

177437:HRM2 RS16150
gene id: 177437:HRM2_RS16150
uniprot id: C0QLP6
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

177437:HRM2 RS02800
gene id: 177437:HRM2_RS02800
uniprot id: C0QIQ1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

177437:HRM2 RS08875
gene id: 177437:HRM2_RS08875
uniprot id: C0QB86
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

177437:HRM2 RS14255
gene id: 177437:HRM2_RS14255
uniprot id: C0QJF9
names: Similarity
messages: Belongs to the heat shock protein 70 family.

177437:HRM2 RS02950
gene id: 177437:HRM2_RS02950
uniprot id: C0QIT1
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

177437:HRM2 RS11570
gene id: 177437:HRM2_RS11570
uniprot id: C0QET3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

177437:HRM2 RS10555
gene id: 177437:HRM2_RS10555
uniprot id: C0QDG7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

177437:HRM2 RS20500
gene id: 177437:HRM2_RS20500
uniprot id: C0QCY3
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS21535
gene id: 177437:HRM2_RS21535
uniprot id: C0QE02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS03355
gene id: 177437:HRM2_RS03355
uniprot id: C0QJ16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

177437:HRM2 RS18990
gene id: 177437:HRM2_RS18990
uniprot id: C0QAX5
names: Similarity
messages: Belongs to the citrate synthase family.

177437:HRM2 RS00590
gene id: 177437:HRM2_RS00590
uniprot id: C0QEC8
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS21730
gene id: 177437:HRM2_RS21730
uniprot id: C0QEW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.
messages: Golgi apparatus
messages: Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.
messages: In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.
messages: In the N-terminal section; belongs to the formiminotransferase family.
messages: centriole

177437:HRM2 RS23420
gene id: 177437:HRM2_RS23420
uniprot id: C0QHC5
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

177437:HRM2 RS11795
gene id: 177437:HRM2_RS11795
uniprot id: C0QFQ1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

177437:HRM2 RS22395
gene id: 177437:HRM2_RS22395
uniprot id: C0QG18
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

177437:HRM2 RS20980
gene id: 177437:HRM2_RS20980
uniprot id: C0QD81
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

177437:HRM2 RS17790
gene id: 177437:HRM2_RS17790
uniprot id: C0Q9U9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

177437:HRM2 RS13775
gene id: 177437:HRM2_RS13775
uniprot id: C0QJ60
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

177437:HRM2 RS17970
gene id: 177437:HRM2_RS17970
uniprot id: C0Q9Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

177437:HRM2 RS07805
gene id: 177437:HRM2_RS07805
uniprot id: C0QA91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

177437:HRM2 RS12320
gene id: 177437:HRM2_RS12320
uniprot id: C0QG04
names: Similarity
messages: Belongs to the peptidase S49 family.

177437:HRM2 RS01590
gene id: 177437:HRM2_RS01590
uniprot id: C0QGH1
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

177437:HRM2 RS08145
gene id: 177437:HRM2_RS08145
uniprot id: C0QAG4
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS13965
gene id: 177437:HRM2_RS13965
uniprot id: C0QJ98
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS09290
gene id: 177437:HRM2_RS09290
uniprot id: C0QBV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

177437:HRM2 RS22500
gene id: 177437:HRM2_RS22500
uniprot id: C0QG38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS06085
gene id: 177437:HRM2_RS06085
uniprot id: C0QM32
names: Similarity
messages: Belongs to the ABC transporter superfamily.

177437:HRM2 RS07920
gene id: 177437:HRM2_RS07920
uniprot id: C0QAB7
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

177437:HRM2 RS01555
gene id: 177437:HRM2_RS01555
uniprot id: C0QGG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS07540
gene id: 177437:HRM2_RS07540
uniprot id: C0Q9R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

177437:HRM2 RS23675
gene id: 177437:HRM2_RS23675
uniprot id: C0QHH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

177437:HRM2 RS02170
gene id: 177437:HRM2_RS02170
uniprot id: C0QHJ9
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

177437:HRM2 RS06955
gene id: 177437:HRM2_RS06955
uniprot id: C0Q9E4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS04720
gene id: 177437:HRM2_RS04720
uniprot id: C0QKK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S16 family.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

177437:HRM2 RS20700
gene id: 177437:HRM2_RS20700
uniprot id: C0QD24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the desulfoferrodoxin family.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.
messages: Homodimer.

177437:HRM2 RS11235
gene id: 177437:HRM2_RS11235
uniprot id: C0QEL8
names: Caution
names: Similarity
messages: Belongs to the NTE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS08715
gene id: 177437:HRM2_RS08715
uniprot id: C0QB55
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
messages: Membrane

177437:HRM2 RS06735
gene id: 177437:HRM2_RS06735
uniprot id: C0Q8X4
names: Cofactor
messages: Binds 1 Mg(2+) ion per subunit.

177437:HRM2 RS08090
gene id: 177437:HRM2_RS08090
uniprot id: C0QAF3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

177437:HRM2 RS12550
gene id: 177437:HRM2_RS12550
uniprot id: C0QGW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

177437:HRM2 RS11140
gene id: 177437:HRM2_RS11140
uniprot id: C0QEK4
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

177437:HRM2 RS12785
gene id: 177437:HRM2_RS12785
uniprot id: C0QH15
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.

177437:HRM2 RS09855
gene id: 177437:HRM2_RS09855
uniprot id: C0QCL2
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS08770
gene id: 177437:HRM2_RS08770
uniprot id: C0QB66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS21125
gene id: 177437:HRM2_RS21125
uniprot id: C0QDS1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS02610
gene id: 177437:HRM2_RS02610
uniprot id: C0QHT3
names: Similarity
messages: Belongs to the AOR/FOR family.

177437:HRM2 RS17820
gene id: 177437:HRM2_RS17820
uniprot id: C0Q9V6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

177437:HRM2 RS04900
gene id: 177437:HRM2_RS04900
uniprot id: C0QL20
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

177437:HRM2 RS03665
gene id: 177437:HRM2_RS03665
uniprot id: C0QJL2
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS16285
gene id: 177437:HRM2_RS16285
uniprot id: C0QLS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

177437:HRM2 RS20020
gene id: 177437:HRM2_RS20020
uniprot id: C0QCA0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

177437:HRM2 RS02760
gene id: 177437:HRM2_RS02760
uniprot id: C0QHX7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

177437:HRM2 RS22680
gene id: 177437:HRM2_RS22680
uniprot id: C0QG73
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS17545
gene id: 177437:HRM2_RS17545
uniprot id: C0Q9B0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

177437:HRM2 RS06835
gene id: 177437:HRM2_RS06835
uniprot id: C0Q8Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS11025
gene id: 177437:HRM2_RS11025
uniprot id: C0QEI1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane

177437:HRM2 RS18975
gene id: 177437:HRM2_RS18975
uniprot id: C0QAX2
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

177437:HRM2 RS02680
gene id: 177437:HRM2_RS02680
uniprot id: C0QHU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS14075
gene id: 177437:HRM2_RS14075
uniprot id: C0QJC2
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS23645
gene id: 177437:HRM2_RS23645
uniprot id: C0QHH1
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

177437:HRM2 RS08480
gene id: 177437:HRM2_RS08480
uniprot id: C0QB12
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

177437:HRM2 RS07870
gene id: 177437:HRM2_RS07870
uniprot id: C0QAA5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

177437:HRM2 RS11160
gene id: 177437:HRM2_RS11160
uniprot id: C0QEK8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

177437:HRM2 RS05075
gene id: 177437:HRM2_RS05075
uniprot id: C0QL56
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

177437:HRM2 RS17735
gene id: 177437:HRM2_RS17735
uniprot id: C0Q9T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

177437:HRM2 RS11760
gene id: 177437:HRM2_RS11760
uniprot id: C0QFP4
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS14985
gene id: 177437:HRM2_RS14985
uniprot id: C0QKM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

177437:HRM2 RS07630
gene id: 177437:HRM2_RS07630
uniprot id: C0QA58
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

177437:HRM2 RS05525
gene id: 177437:HRM2_RS05525
uniprot id: C0QLE5
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

177437:HRM2 RS05530
gene id: 177437:HRM2_RS05530
uniprot id: C0QLE6
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

177437:HRM2 RS06270
gene id: 177437:HRM2_RS06270
uniprot id: C0Q8N6
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS17395
gene id: 177437:HRM2_RS17395
uniprot id: C0Q984
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

177437:HRM2 RS19105
gene id: 177437:HRM2_RS19105
uniprot id: C0QBC8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS16875
gene id: 177437:HRM2_RS16875
uniprot id: C0QMH5
names: Subunit
messages: Heterodimer of a large and a small subunit.

177437:HRM2 RS09950
gene id: 177437:HRM2_RS09950
uniprot id: C0QCN2
names: Similarity
messages: Belongs to the CapA family.

177437:HRM2 RS15490
gene id: 177437:HRM2_RS15490
uniprot id: C0QKX9
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

177437:HRM2 RS05200
gene id: 177437:HRM2_RS05200
uniprot id: C0QL81
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

177437:HRM2 RS19890
gene id: 177437:HRM2_RS19890
uniprot id: C0QC75
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS18230
gene id: 177437:HRM2_RS18230
uniprot id: C0QA35
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Secreted

177437:HRM2 RS17900
gene id: 177437:HRM2_RS17900
uniprot id: C0Q9X3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

177437:HRM2 RS06840
gene id: 177437:HRM2_RS06840
uniprot id: C0Q8Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS15065
gene id: 177437:HRM2_RS15065
uniprot id: C0QKP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

177437:HRM2 RS09250
gene id: 177437:HRM2_RS09250
uniprot id: C0QBU5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

177437:HRM2 RS08295
gene id: 177437:HRM2_RS08295
uniprot id: C0QAX9
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

177437:HRM2 RS00030
gene id: 177437:HRM2_RS00030
uniprot id: C0QD91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

177437:HRM2 RS06650
gene id: 177437:HRM2_RS06650
uniprot id: C0Q8V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase epsilon chain family.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

177437:HRM2 RS00490
gene id: 177437:HRM2_RS00490
uniprot id: C0QEA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS15280
gene id: 177437:HRM2_RS15280
uniprot id: C0QKT8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

177437:HRM2 RS17780
gene id: 177437:HRM2_RS17780
uniprot id: C0Q9U7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

177437:HRM2 RS13335
gene id: 177437:HRM2_RS13335
uniprot id: C0QI51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

177437:HRM2 RS17860
gene id: 177437:HRM2_RS17860
uniprot id: C0Q9W5
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

177437:HRM2 RS17835
gene id: 177437:HRM2_RS17835
uniprot id: C0Q9V9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

177437:HRM2 RS12310
gene id: 177437:HRM2_RS12310
uniprot id: C0QG02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

177437:HRM2 RS21140
gene id: 177437:HRM2_RS21140
uniprot id: C0QDS4
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS05395
gene id: 177437:HRM2_RS05395
uniprot id: C0QLB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

177437:HRM2 RS02265
gene id: 177437:HRM2_RS02265
uniprot id: C0QHL6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

177437:HRM2 RS06825
gene id: 177437:HRM2_RS06825
uniprot id: C0Q8Z2
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

177437:HRM2 RS06570
gene id: 177437:HRM2_RS06570
uniprot id: C0Q8U5
names: Similarity
messages: Belongs to the D-alanine--D-alanine ligase family.

177437:HRM2 RS17255
gene id: 177437:HRM2_RS17255
uniprot id: C0Q961
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS16125
gene id: 177437:HRM2_RS16125
uniprot id: C0QLP1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

177437:HRM2 RS01205
gene id: 177437:HRM2_RS01205
uniprot id: C0QFH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Periplasm
messages: Secreted

177437:HRM2 RS07260
gene id: 177437:HRM2_RS07260
uniprot id: C0Q9J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

177437:HRM2 RS09110
gene id: 177437:HRM2_RS09110
uniprot id: C0QBR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell inner membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

177437:HRM2 RS08390
gene id: 177437:HRM2_RS08390
uniprot id: C0QAZ6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

177437:HRM2 RS22325
gene id: 177437:HRM2_RS22325
uniprot id: C0QF82
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

177437:HRM2 RS11405
gene id: 177437:HRM2_RS11405
uniprot id: C0QEQ0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

177437:HRM2 RS17745
gene id: 177437:HRM2_RS17745
uniprot id: C0Q9T9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Homotetramer.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

177437:HRM2 RS19640
gene id: 177437:HRM2_RS19640
uniprot id: C0QBP0
names: Similarity
messages: Belongs to the glutamate synthase family.

177437:HRM2 RS13215
gene id: 177437:HRM2_RS13215
uniprot id: C0QI27
names: Similarity
messages: Belongs to the universal stress protein A family.

177437:HRM2 RS13195
gene id: 177437:HRM2_RS13195
uniprot id: C0QI23
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: May bind 1 zinc ion per subunit.
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

177437:HRM2 RS19805
gene id: 177437:HRM2_RS19805
uniprot id: C0QC58
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

177437:HRM2 RS12880
gene id: 177437:HRM2_RS12880
uniprot id: C0QH35
names: Similarity
messages: Belongs to the type IA topoisomerase family.

177437:HRM2 RS18155
gene id: 177437:HRM2_RS18155
uniprot id: C0QA19
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

177437:HRM2 RS17890
gene id: 177437:HRM2_RS17890
uniprot id: C0Q9X1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

177437:HRM2 RS11880
gene id: 177437:HRM2_RS11880
uniprot id: C0QFR8
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

177437:HRM2 RS11470
gene id: 177437:HRM2_RS11470
uniprot id: C0QER3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

177437:HRM2 RS01530
gene id: 177437:HRM2_RS01530
uniprot id: C0QGF8
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

177437:HRM2 RS15885
gene id: 177437:HRM2_RS15885
uniprot id: C0QLJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

177437:HRM2 RS02955
gene id: 177437:HRM2_RS02955
uniprot id: C0QIT2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS09030
gene id: 177437:HRM2_RS09030
uniprot id: C0QBQ1
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

177437:HRM2 RS15845
gene id: 177437:HRM2_RS15845
uniprot id: C0QLI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

177437:HRM2 RS13485
gene id: 177437:HRM2_RS13485
uniprot id: C0QI79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

177437:HRM2 RS00880
gene id: 177437:HRM2_RS00880
uniprot id: C0QFA9
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

177437:HRM2 RS03055
gene id: 177437:HRM2_RS03055
uniprot id: C0QIV2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

177437:HRM2 RS19945
gene id: 177437:HRM2_RS19945
uniprot id: C0QC86
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

177437:HRM2 RS07020
gene id: 177437:HRM2_RS07020
uniprot id: C0Q9F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

177437:HRM2 RS00265
gene id: 177437:HRM2_RS00265
uniprot id: C0QE63
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

177437:HRM2 RS11930
gene id: 177437:HRM2_RS11930
uniprot id: C0QFS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

177437:HRM2 RS08055
gene id: 177437:HRM2_RS08055
uniprot id: C0QAE7
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS19830
gene id: 177437:HRM2_RS19830
uniprot id: C0QC63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

177437:HRM2 RS20715
gene id: 177437:HRM2_RS20715
uniprot id: C0QD27
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS09085
gene id: 177437:HRM2_RS09085
uniprot id: C0QBR2
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS11605
gene id: 177437:HRM2_RS11605
uniprot id: C0QEU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

177437:HRM2 RS04315
gene id: 177437:HRM2_RS04315
uniprot id: C0QKC1
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

177437:HRM2 RS16500
gene id: 177437:HRM2_RS16500
uniprot id: C0QMA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

177437:HRM2 RS21475
gene id: 177437:HRM2_RS21475
uniprot id: C0QDZ0
names: Subcellular Location Annotation
messages: Cell inner membrane

177437:HRM2 RS03360
gene id: 177437:HRM2_RS03360
uniprot id: C0QJ17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

177437:HRM2 RS06280
gene id: 177437:HRM2_RS06280
uniprot id: C0Q8N8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS05500
gene id: 177437:HRM2_RS05500
uniprot id: C0QLE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

177437:HRM2 RS09140
gene id: 177437:HRM2_RS09140
uniprot id: C0QBS4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS05635
gene id: 177437:HRM2_RS05635
uniprot id: C0QLU7
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS21055
gene id: 177437:HRM2_RS21055
uniprot id: C0QDQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

177437:HRM2 RS21250
gene id: 177437:HRM2_RS21250
uniprot id: C0QDU4
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

177437:HRM2 RS04360
gene id: 177437:HRM2_RS04360
uniprot id: C0QKD0
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

177437:HRM2 RS09280
gene id: 177437:HRM2_RS09280
uniprot id: C0QBV1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

177437:HRM2 RS12185
gene id: 177437:HRM2_RS12185
uniprot id: C0QFX7
names: Similarity
messages: Belongs to the peptidase M1 family.

177437:HRM2 RS13200
gene id: 177437:HRM2_RS13200
uniprot id: C0QI24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

177437:HRM2 RS02185
gene id: 177437:HRM2_RS02185
uniprot id: C0QHK0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

177437:HRM2 RS01985
gene id: 177437:HRM2_RS01985
uniprot id: C0QGP6
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

177437:HRM2 RS21305
gene id: 177437:HRM2_RS21305
uniprot id: C0QDV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

177437:HRM2 RS04760
gene id: 177437:HRM2_RS04760
uniprot id: C0QKK8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg-97 inactivates the nitrogenase reductase and regulates nitrogenase activity.

177437:HRM2 RS22520
gene id: 177437:HRM2_RS22520
uniprot id: C0QG42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

177437:HRM2 RS00380
gene id: 177437:HRM2_RS00380
uniprot id: C0QE86
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

177437:HRM2 RS05760
gene id: 177437:HRM2_RS05760
uniprot id: C0QLX1
names: Similarity
messages: Belongs to the thioredoxin family.

177437:HRM2 RS04935
gene id: 177437:HRM2_RS04935
uniprot id: C0QL27
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

177437:HRM2 RS21455
gene id: 177437:HRM2_RS21455
uniprot id: C0QDY6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

177437:HRM2 RS05770
gene id: 177437:HRM2_RS05770
uniprot id: C0QLX3
names: Similarity
messages: Belongs to the peptidase A31 family.

177437:HRM2 RS14950
gene id: 177437:HRM2_RS14950
uniprot id: C0QK85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

177437:HRM2 RS00150
gene id: 177437:HRM2_RS00150
uniprot id: C0QE40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS20775
gene id: 177437:HRM2_RS20775
uniprot id: C0QD41
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS24950
gene id: 177437:HRM2_RS24950
uniprot id: C0QJP9
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS16800
gene id: 177437:HRM2_RS16800
uniprot id: C0QMG1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

177437:HRM2 RS10835
gene id: 177437:HRM2_RS10835
uniprot id: C0QDM3
names: Similarity
messages: Belongs to the FBPase class 2 family.

177437:HRM2 RS13745
gene id: 177437:HRM2_RS13745
uniprot id: C0QJ54
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

177437:HRM2 RS14930
gene id: 177437:HRM2_RS14930
uniprot id: C0QK81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

177437:HRM2 RS15665
gene id: 177437:HRM2_RS15665
uniprot id: C0QLF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

177437:HRM2 RS19160
gene id: 177437:HRM2_RS19160
uniprot id: C0QBE0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS04785
gene id: 177437:HRM2_RS04785
uniprot id: C0QKL3
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

177437:HRM2 RS13365
gene id: 177437:HRM2_RS13365
uniprot id: C0QI55
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

177437:HRM2 RS04485
gene id: 177437:HRM2_RS04485
uniprot id: C0QKF6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

177437:HRM2 RS17090
gene id: 177437:HRM2_RS17090
uniprot id: C0Q931
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS22285
gene id: 177437:HRM2_RS22285
uniprot id: C0QF74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

177437:HRM2 RS02605
gene id: 177437:HRM2_RS02605
uniprot id: C0QHT2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.

177437:HRM2 RS06990
gene id: 177437:HRM2_RS06990
uniprot id: C0Q9F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS01550
gene id: 177437:HRM2_RS01550
uniprot id: C0QGG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS03240
gene id: 177437:HRM2_RS03240
uniprot id: C0QIZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

177437:HRM2 RS15725
gene id: 177437:HRM2_RS15725
uniprot id: C0QLG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

177437:HRM2 RS12520
gene id: 177437:HRM2_RS12520
uniprot id: C0QGW3
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

177437:HRM2 RS09255
gene id: 177437:HRM2_RS09255
uniprot id: C0QBU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

177437:HRM2 RS11660
gene id: 177437:HRM2_RS11660
uniprot id: C0QEV1
names: Similarity
messages: Belongs to the elongation factor P family.

177437:HRM2 RS00195
gene id: 177437:HRM2_RS00195
uniprot id: C0QE49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

177437:HRM2 RS13530
gene id: 177437:HRM2_RS13530
uniprot id: C0QI88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS17825
gene id: 177437:HRM2_RS17825
uniprot id: C0Q9V7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

177437:HRM2 RS16815
gene id: 177437:HRM2_RS16815
uniprot id: C0QMG4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

177437:HRM2 RS15650
gene id: 177437:HRM2_RS15650
uniprot id: C0QLE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

177437:HRM2 RS21735
gene id: 177437:HRM2_RS21735
uniprot id: C0QEW2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS25680
gene id: 177437:HRM2_RS25680
uniprot id: C0QGD6
names: Similarity
messages: Belongs to the universal stress protein A family.

177437:HRM2 RS02790
gene id: 177437:HRM2_RS02790
uniprot id: C0QIP9
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS01795
gene id: 177437:HRM2_RS01795
uniprot id: C0QGK9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

177437:HRM2 RS15875
gene id: 177437:HRM2_RS15875
uniprot id: C0QLJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

177437:HRM2 RS02995
gene id: 177437:HRM2_RS02995
uniprot id: C0QIU0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

177437:HRM2 RS05805
gene id: 177437:HRM2_RS05805
uniprot id: C0QLX9
names: Subcellular Location Annotation
messages: Periplasm

177437:HRM2 RS11375
gene id: 177437:HRM2_RS11375
uniprot id: C0QEP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

177437:HRM2 RS04395
gene id: 177437:HRM2_RS04395
uniprot id: C0QKD8
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS02490
gene id: 177437:HRM2_RS02490
uniprot id: C0QHQ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

177437:HRM2 RS05290
gene id: 177437:HRM2_RS05290
uniprot id: C0QL99
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

177437:HRM2 RS09195
gene id: 177437:HRM2_RS09195
uniprot id: C0QBT5
names: Similarity
messages: Belongs to the RemA family.

177437:HRM2 RS12230
gene id: 177437:HRM2_RS12230
uniprot id: C0QFY6
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS15390
gene id: 177437:HRM2_RS15390
uniprot id: C0QKW0
names: Similarity
messages: Belongs to the UPF0251 family.

177437:HRM2 RS04270
gene id: 177437:HRM2_RS04270
uniprot id: C0QKB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane
messages: Responsible for the transport of C4-dicarboxylates.

177437:HRM2 RS22700
gene id: 177437:HRM2_RS22700
uniprot id: C0QG76
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

177437:HRM2 RS13385
gene id: 177437:HRM2_RS13385
uniprot id: C0QI59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

177437:HRM2 RS06125
gene id: 177437:HRM2_RS06125
uniprot id: C0QM40
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS17775
gene id: 177437:HRM2_RS17775
uniprot id: C0Q9U6
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

177437:HRM2 RS17945
gene id: 177437:HRM2_RS17945
uniprot id: C0Q9Y2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

177437:HRM2 RS23290
gene id: 177437:HRM2_RS23290
uniprot id: C0QHA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS01230
gene id: 177437:HRM2_RS01230
uniprot id: C0QFH9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

177437:HRM2 RS14360
gene id: 177437:HRM2_RS14360
uniprot id: C0QJW7
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

177437:HRM2 RS16330
gene id: 177437:HRM2_RS16330
uniprot id: C0QM67
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

177437:HRM2 RS10755
gene id: 177437:HRM2_RS10755
uniprot id: C0QDK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

177437:HRM2 RS13640
gene id: 177437:HRM2_RS13640
uniprot id: C0QIB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

177437:HRM2 RS05255
gene id: 177437:HRM2_RS05255
uniprot id: C0QL92
names: Similarity
messages: Belongs to the SUI1 family.

177437:HRM2 RS21760
gene id: 177437:HRM2_RS21760
uniprot id: C0QEW8
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

177437:HRM2 RS20860
gene id: 177437:HRM2_RS20860
uniprot id: C0QD58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

177437:HRM2 RS01460
gene id: 177437:HRM2_RS01460
uniprot id: C0QFM3
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

177437:HRM2 RS18320
gene id: 177437:HRM2_RS18320
uniprot id: C0QA53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

177437:HRM2 RS02220
gene id: 177437:HRM2_RS02220
uniprot id: C0QHK7
names: Similarity
messages: Belongs to the HdrA family.

177437:HRM2 RS14975
gene id: 177437:HRM2_RS14975
uniprot id: C0QKM7
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

177437:HRM2 RS15425
gene id: 177437:HRM2_RS15425
uniprot id: C0QKW7
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

177437:HRM2 RS09375
gene id: 177437:HRM2_RS09375
uniprot id: C0QBW9
names: Similarity
messages: Belongs to the peptidase S41A family.

177437:HRM2 RS10535
gene id: 177437:HRM2_RS10535
uniprot id: C0QDG3
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS16030
gene id: 177437:HRM2_RS16030
uniprot id: C0QLM3
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

177437:HRM2 RS08530
gene id: 177437:HRM2_RS08530
uniprot id: C0QB22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

177437:HRM2 RS17685
gene id: 177437:HRM2_RS17685
uniprot id: C0Q9S7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

177437:HRM2 RS11420
gene id: 177437:HRM2_RS11420
uniprot id: C0QEQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS10085
gene id: 177437:HRM2_RS10085
uniprot id: C0QCQ9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

177437:HRM2 RS10100
gene id: 177437:HRM2_RS10100
uniprot id: C0QCR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS08430
gene id: 177437:HRM2_RS08430
uniprot id: C0QB03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

177437:HRM2 RS04280
gene id: 177437:HRM2_RS04280
uniprot id: C0QKB4
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

177437:HRM2 RS16740
gene id: 177437:HRM2_RS16740
uniprot id: C0QME8
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS12085
gene id: 177437:HRM2_RS12085
uniprot id: C0QFV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

177437:HRM2 RS23985
gene id: 177437:HRM2_RS23985
uniprot id: C0QIF2
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

177437:HRM2 RS10710
gene id: 177437:HRM2_RS10710
uniprot id: C0QDJ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

177437:HRM2 RS06055
gene id: 177437:HRM2_RS06055
uniprot id: C0QM26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS00525
gene id: 177437:HRM2_RS00525
uniprot id: C0QEB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

177437:HRM2 RS06945
gene id: 177437:HRM2_RS06945
uniprot id: C0Q9E2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 7 family.
messages: Homodimer.
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: Periplasm

177437:HRM2 RS04715
gene id: 177437:HRM2_RS04715
uniprot id: C0QKJ9
names: Similarity
messages: Belongs to the class-II DAHP synthase family.

177437:HRM2 RS02700
gene id: 177437:HRM2_RS02700
uniprot id: C0QHV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

177437:HRM2 RS27780
gene id: 177437:HRM2_RS27780
uniprot id: C0QAJ6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

177437:HRM2 RS11115
gene id: 177437:HRM2_RS11115
uniprot id: C0QEJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

177437:HRM2 RS05740
gene id: 177437:HRM2_RS05740
uniprot id: C0QLW7
names: Similarity
messages: Belongs to the HypD family.

177437:HRM2 RS00285
gene id: 177437:HRM2_RS00285
uniprot id: C0QE66
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS16515
gene id: 177437:HRM2_RS16515
uniprot id: C0QMA4
names: Similarity
messages: Belongs to the universal stress protein A family.

177437:HRM2 RS01630
gene id: 177437:HRM2_RS01630
uniprot id: C0QGI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS05330
gene id: 177437:HRM2_RS05330
uniprot id: C0QLA7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

177437:HRM2 RS07565
gene id: 177437:HRM2_RS07565
uniprot id: C0Q9R6
names: Similarity
messages: Belongs to the universal stress protein A family.

177437:HRM2 RS12575
gene id: 177437:HRM2_RS12575
uniprot id: C0QGX4
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS12760
gene id: 177437:HRM2_RS12760
uniprot id: C0QH10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

177437:HRM2 RS17385
gene id: 177437:HRM2_RS17385
uniprot id: C0Q982
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

177437:HRM2 RS05335
gene id: 177437:HRM2_RS05335
uniprot id: C0QLA8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

177437:HRM2 RS01535
gene id: 177437:HRM2_RS01535
uniprot id: C0QGF9
names: Similarity
messages: Belongs to the RutC family.

177437:HRM2 RS15005
gene id: 177437:HRM2_RS15005
uniprot id: C0QKN3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

177437:HRM2 RS13110
gene id: 177437:HRM2_RS13110
uniprot id: C0QI06
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
messages: Belongs to the RecD family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

177437:HRM2 RS25125
gene id: 177437:HRM2_RS25125
uniprot id: C0QBW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-ACP thioesterase family.
messages: chloroplast

177437:HRM2 RS13750
gene id: 177437:HRM2_RS13750
uniprot id: C0QJ55
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

177437:HRM2 RS06830
gene id: 177437:HRM2_RS06830
uniprot id: C0Q8Z3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

177437:HRM2 RS13375
gene id: 177437:HRM2_RS13375
uniprot id: C0QI57
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

177437:HRM2 RS14125
gene id: 177437:HRM2_RS14125
uniprot id: C0QJD2
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS15020
gene id: 177437:HRM2_RS15020
uniprot id: C0QKN6
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

177437:HRM2 RS24205
gene id: 177437:HRM2_RS24205
uniprot id: C0QIJ8
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

177437:HRM2 RS03455
gene id: 177437:HRM2_RS03455
uniprot id: C0QJH3
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS13295
gene id: 177437:HRM2_RS13295
uniprot id: C0QI43
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

177437:HRM2 RS08350
gene id: 177437:HRM2_RS08350
uniprot id: C0QAY9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

177437:HRM2 RS05705
gene id: 177437:HRM2_RS05705
uniprot id: C0QLW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

177437:HRM2 RS06630
gene id: 177437:HRM2_RS06630
uniprot id: C0Q8V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

177437:HRM2 RS14525
gene id: 177437:HRM2_RS14525
uniprot id: C0QJZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

177437:HRM2 RS01120
gene id: 177437:HRM2_RS01120
uniprot id: C0QFF7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

177437:HRM2 RS19925
gene id: 177437:HRM2_RS19925
uniprot id: C0QC82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

177437:HRM2 RS03275
gene id: 177437:HRM2_RS03275
uniprot id: C0QJ00
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family. 5-hydroxybenzimidazole synthase subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Is thus involved in the anaerobic biosynthesis of the benzimidazole lower axial ligand of the cobamide produced by D.autotrophicum.
messages: Homodimer.

177437:HRM2 RS21255
gene id: 177437:HRM2_RS21255
uniprot id: C0QDU5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

177437:HRM2 RS21765
gene id: 177437:HRM2_RS21765
uniprot id: C0QEW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS01320
gene id: 177437:HRM2_RS01320
uniprot id: C0QFJ6
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

177437:HRM2 RS18120
gene id: 177437:HRM2_RS18120
uniprot id: C0QA12
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

177437:HRM2 RS13240
gene id: 177437:HRM2_RS13240
uniprot id: C0QI32
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

177437:HRM2 RS00230
gene id: 177437:HRM2_RS00230
uniprot id: C0QE56
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS01915
gene id: 177437:HRM2_RS01915
uniprot id: C0QGN1
names: Similarity
messages: Belongs to the peptidase S24 family.

177437:HRM2 RS17715
gene id: 177437:HRM2_RS17715
uniprot id: C0Q9T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

177437:HRM2 RS08245
gene id: 177437:HRM2_RS08245
uniprot id: C0QAI3
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

177437:HRM2 RS10310
gene id: 177437:HRM2_RS10310
uniprot id: C0QDB9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.
messages: Belongs to the ParB family.

177437:HRM2 RS16205
gene id: 177437:HRM2_RS16205
uniprot id: C0QLQ6
names: Similarity
messages: Belongs to the DEAD box helicase family.

177437:HRM2 RS02440
gene id: 177437:HRM2_RS02440
uniprot id: C0QHP9
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS01505
gene id: 177437:HRM2_RS01505
uniprot id: C0QGF3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

177437:HRM2 RS18830
gene id: 177437:HRM2_RS18830
uniprot id: C0QAU2
names: Function
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

177437:HRM2 RS06715
gene id: 177437:HRM2_RS06715
uniprot id: C0Q8X2
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

177437:HRM2 RS08780
gene id: 177437:HRM2_RS08780
uniprot id: C0QB68
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

177437:HRM2 RS08500
gene id: 177437:HRM2_RS08500
uniprot id: C0QB16
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

177437:HRM2 RS19130
gene id: 177437:HRM2_RS19130
uniprot id: C0QBD3
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.

177437:HRM2 RS24280
gene id: 177437:HRM2_RS24280
uniprot id: C0QIL4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

177437:HRM2 RS13205
gene id: 177437:HRM2_RS13205
uniprot id: C0QI25
names: Similarity
messages: Belongs to the ClpA/ClpB family.

177437:HRM2 RS03550
gene id: 177437:HRM2_RS03550
uniprot id: C0QJI9
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

177437:HRM2 RS25300
gene id: 177437:HRM2_RS25300
uniprot id: C0QI81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

177437:HRM2 RS10380
gene id: 177437:HRM2_RS10380
uniprot id: C0QDD1
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

177437:HRM2 RS22670
gene id: 177437:HRM2_RS22670
uniprot id: C0QG71
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

177437:HRM2 RS03755
gene id: 177437:HRM2_RS03755
uniprot id: C0QJM9
names: Function
names: Similarity
messages: Belongs to the CbiK family.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin.

177437:HRM2 RS17905
gene id: 177437:HRM2_RS17905
uniprot id: C0Q9X4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

177437:HRM2 RS13120
gene id: 177437:HRM2_RS13120
uniprot id: C0QI08
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
messages: Belongs to the RecC family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

177437:HRM2 RS00215
gene id: 177437:HRM2_RS00215
uniprot id: C0QE53
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

177437:HRM2 RS02415
gene id: 177437:HRM2_RS02415
uniprot id: C0QHP4
names: Similarity
messages: Belongs to the AOR/FOR family.

177437:HRM2 RS25010
gene id: 177437:HRM2_RS25010
uniprot id: C0Q9H5
names: Subunit
messages: Heterodimer of a large and a small subunit.

177437:HRM2 RS14295
gene id: 177437:HRM2_RS14295
uniprot id: C0QJG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
messages: Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
messages: Homotetramer.

177437:HRM2 RS00950
gene id: 177437:HRM2_RS00950
uniprot id: C0QFC3
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

177437:HRM2 RS02300
gene id: 177437:HRM2_RS02300
uniprot id: C0QHM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

177437:HRM2 RS10915
gene id: 177437:HRM2_RS10915
uniprot id: C0QDN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

177437:HRM2 RS13990
gene id: 177437:HRM2_RS13990
uniprot id: C0QJA2
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

177437:HRM2 RS02530
gene id: 177437:HRM2_RS02530
uniprot id: C0QHR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS07100
gene id: 177437:HRM2_RS07100
uniprot id: C0Q9H1
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS16245
gene id: 177437:HRM2_RS16245
uniprot id: C0QLR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS18235
gene id: 177437:HRM2_RS18235
uniprot id: C0QA36
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

177437:HRM2 RS03380
gene id: 177437:HRM2_RS03380
uniprot id: C0QJ21
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrF family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

177437:HRM2 RS21060
gene id: 177437:HRM2_RS21060
uniprot id: C0QDQ8
names: Similarity
messages: Belongs to the FeoA family.

177437:HRM2 RS17710
gene id: 177437:HRM2_RS17710
uniprot id: C0Q9T2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS11415
gene id: 177437:HRM2_RS11415
uniprot id: C0QEQ2
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

177437:HRM2 RS17450
gene id: 177437:HRM2_RS17450
uniprot id: C0Q993
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS07025
gene id: 177437:HRM2_RS07025
uniprot id: C0Q9F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS15305
gene id: 177437:HRM2_RS15305
uniprot id: C0QKU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

177437:HRM2 RS05185
gene id: 177437:HRM2_RS05185
uniprot id: C0QL78
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

177437:HRM2 RS08545
gene id: 177437:HRM2_RS08545
uniprot id: C0QB25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

177437:HRM2 RS05480
gene id: 177437:HRM2_RS05480
uniprot id: C0QLD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

177437:HRM2 RS24125
gene id: 177437:HRM2_RS24125
uniprot id: C0QII0
names: Similarity
messages: Belongs to the leucine-binding protein family.

177437:HRM2 RS01310
gene id: 177437:HRM2_RS01310
uniprot id: C0QFJ5
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

177437:HRM2 RS00275
gene id: 177437:HRM2_RS00275
uniprot id: C0QE65
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

177437:HRM2 RS08340
gene id: 177437:HRM2_RS08340
uniprot id: C0QAY8
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

177437:HRM2 RS17880
gene id: 177437:HRM2_RS17880
uniprot id: C0Q9W9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

177437:HRM2 RS09155
gene id: 177437:HRM2_RS09155
uniprot id: C0QBS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS15465
gene id: 177437:HRM2_RS15465
uniprot id: C0QKX5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

177437:HRM2 RS12485
gene id: 177437:HRM2_RS12485
uniprot id: C0QGV6
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS10650
gene id: 177437:HRM2_RS10650
uniprot id: C0QDI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS14020
gene id: 177437:HRM2_RS14020
uniprot id: C0QJB0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

177437:HRM2 RS06115
gene id: 177437:HRM2_RS06115
uniprot id: C0QM38
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

177437:HRM2 RS05465
gene id: 177437:HRM2_RS05465
uniprot id: C0QLD3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

177437:HRM2 RS17760
gene id: 177437:HRM2_RS17760
uniprot id: C0Q9U3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

177437:HRM2 RS17540
gene id: 177437:HRM2_RS17540
uniprot id: C0Q9A9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS05645
gene id: 177437:HRM2_RS05645
uniprot id: C0QLU9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

177437:HRM2 RS12380
gene id: 177437:HRM2_RS12380
uniprot id: C0QGT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

177437:HRM2 RS23835
gene id: 177437:HRM2_RS23835
uniprot id: C0QIC3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS20875
gene id: 177437:HRM2_RS20875
uniprot id: C0QD61
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

177437:HRM2 RS20765
gene id: 177437:HRM2_RS20765
uniprot id: C0QD39
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

177437:HRM2 RS01155
gene id: 177437:HRM2_RS01155
uniprot id: C0QFG4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

177437:HRM2 RS19915
gene id: 177437:HRM2_RS19915
uniprot id: C0QC80
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS18040
gene id: 177437:HRM2_RS18040
uniprot id: C0Q9Z7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

177437:HRM2 RS25040
gene id: 177437:HRM2_RS25040
uniprot id: C0Q9P9
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS11440
gene id: 177437:HRM2_RS11440
uniprot id: C0QEQ7
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

177437:HRM2 RS07685
gene id: 177437:HRM2_RS07685
uniprot id: C0QA70
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

177437:HRM2 RS24835
gene id: 177437:HRM2_RS24835
uniprot id: C0QFD5
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS11485
gene id: 177437:HRM2_RS11485
uniprot id: C0QER6
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

177437:HRM2 RS05555
gene id: 177437:HRM2_RS05555
uniprot id: C0QLT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

177437:HRM2 RS22530
gene id: 177437:HRM2_RS22530
uniprot id: C0QG44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell inner membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

177437:HRM2 RS22300
gene id: 177437:HRM2_RS22300
uniprot id: C0QF77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS16295
gene id: 177437:HRM2_RS16295
uniprot id: C0QLS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell inner membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

177437:HRM2 RS20045
gene id: 177437:HRM2_RS20045
uniprot id: C0QCA5
names: Similarity
messages: Belongs to the SfsA family.

177437:HRM2 RS11110
gene id: 177437:HRM2_RS11110
uniprot id: C0QEJ8
names: Similarity
messages: Belongs to the Skp family.

177437:HRM2 RS01520
gene id: 177437:HRM2_RS01520
uniprot id: C0QGF6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

177437:HRM2 RS17380
gene id: 177437:HRM2_RS17380
uniprot id: C0Q981
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

177437:HRM2 RS14615
gene id: 177437:HRM2_RS14615
uniprot id: C0QK18
names: Similarity
messages: Belongs to the ABC transporter superfamily.

177437:HRM2 RS22430
gene id: 177437:HRM2_RS22430
uniprot id: C0QG25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS14940
gene id: 177437:HRM2_RS14940
uniprot id: C0QK83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.
messages: Belongs to the GSP E family.
messages: Cell inner membrane

177437:HRM2 RS18325
gene id: 177437:HRM2_RS18325
uniprot id: C0QA54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

177437:HRM2 RS00845
gene id: 177437:HRM2_RS00845
uniprot id: C0QFA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

177437:HRM2 RS02560
gene id: 177437:HRM2_RS02560
uniprot id: C0QHS3
names: Similarity
messages: Belongs to the Ahb/Nir family.

177437:HRM2 RS20865
gene id: 177437:HRM2_RS20865
uniprot id: C0QD59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

177437:HRM2 RS01750
gene id: 177437:HRM2_RS01750
uniprot id: C0QGK1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutB family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

177437:HRM2 RS23270
gene id: 177437:HRM2_RS23270
uniprot id: C0QH97
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

177437:HRM2 RS18930
gene id: 177437:HRM2_RS18930
uniprot id: C0QAW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS19670
gene id: 177437:HRM2_RS19670
uniprot id: C0QC31
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

177437:HRM2 RS06265
gene id: 177437:HRM2_RS06265
uniprot id: C0Q8N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

177437:HRM2 RS20165
gene id: 177437:HRM2_RS20165
uniprot id: C0QCC9
names: Similarity
messages: Belongs to the peptidase S24 family.

177437:HRM2 RS21500
gene id: 177437:HRM2_RS21500
uniprot id: C0QDZ4
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

177437:HRM2 RS00080
gene id: 177437:HRM2_RS00080
uniprot id: C0QDA3
names: Similarity
messages: Belongs to the CobH/CbiC family.

177437:HRM2 RS23875
gene id: 177437:HRM2_RS23875
uniprot id: C0QID0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS01480
gene id: 177437:HRM2_RS01480
uniprot id: C0QGE8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

177437:HRM2 RS01925
gene id: 177437:HRM2_RS01925
uniprot id: C0QGN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

177437:HRM2 RS15225
gene id: 177437:HRM2_RS15225
uniprot id: C0QKS8
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

177437:HRM2 RS10430
gene id: 177437:HRM2_RS10430
uniprot id: C0QDE2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

177437:HRM2 RS15620
gene id: 177437:HRM2_RS15620
uniprot id: C0QL05
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS23100
gene id: 177437:HRM2_RS23100
uniprot id: C0QH72
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS08005
gene id: 177437:HRM2_RS08005
uniprot id: C0QAD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS06185
gene id: 177437:HRM2_RS06185
uniprot id: C0QM52
names: Cofactor
messages: Binds 1 FAD per subunit.

177437:HRM2 RS05650
gene id: 177437:HRM2_RS05650
uniprot id: C0QLV0
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

177437:HRM2 RS00330
gene id: 177437:HRM2_RS00330
uniprot id: C0QE75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

177437:HRM2 RS16080
gene id: 177437:HRM2_RS16080
uniprot id: C0QLN2
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

177437:HRM2 RS19230
gene id: 177437:HRM2_RS19230
uniprot id: C0QBF5
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS15075
gene id: 177437:HRM2_RS15075
uniprot id: C0QKP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

177437:HRM2 RS00050
gene id: 177437:HRM2_RS00050
uniprot id: C0QD95
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

177437:HRM2 RS14965
gene id: 177437:HRM2_RS14965
uniprot id: C0QK89
names: Similarity
messages: Belongs to the peptidase M18 family.

177437:HRM2 RS06675
gene id: 177437:HRM2_RS06675
uniprot id: C0Q8W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

177437:HRM2 RS24220
gene id: 177437:HRM2_RS24220
uniprot id: C0QIK2
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

177437:HRM2 RS05080
gene id: 177437:HRM2_RS05080
uniprot id: C0QL57
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

177437:HRM2 RS02295
gene id: 177437:HRM2_RS02295
uniprot id: C0QHM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

177437:HRM2 RS08130
gene id: 177437:HRM2_RS08130
uniprot id: C0QAG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

177437:HRM2 RS10560
gene id: 177437:HRM2_RS10560
uniprot id: C0QDG8
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

177437:HRM2 RS13795
gene id: 177437:HRM2_RS13795
uniprot id: C0QJ64
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

177437:HRM2 RS14895
gene id: 177437:HRM2_RS14895
uniprot id: C0QK72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

177437:HRM2 RS13245
gene id: 177437:HRM2_RS13245
uniprot id: C0QI33
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

177437:HRM2 RS03635
gene id: 177437:HRM2_RS03635
uniprot id: C0QJK6
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

177437:HRM2 RS17920
gene id: 177437:HRM2_RS17920
uniprot id: C0Q9X7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

177437:HRM2 RS11520
gene id: 177437:HRM2_RS11520
uniprot id: C0QES3
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS12260
gene id: 177437:HRM2_RS12260
uniprot id: C0QFZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

177437:HRM2 RS14810
gene id: 177437:HRM2_RS14810
uniprot id: C0QK55
names: Similarity
messages: Belongs to the ABC transporter superfamily.

177437:HRM2 RS17260
gene id: 177437:HRM2_RS17260
uniprot id: C0Q962
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS13020
gene id: 177437:HRM2_RS13020
uniprot id: C0QHY8
names: Similarity
messages: Belongs to the peptidase S8 family.

177437:HRM2 RS23450
gene id: 177437:HRM2_RS23450
uniprot id: C0QHD3
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

177437:HRM2 RS14165
gene id: 177437:HRM2_RS14165
uniprot id: C0QJE1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

177437:HRM2 RS18885
gene id: 177437:HRM2_RS18885
uniprot id: C0QAV2
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS18205
gene id: 177437:HRM2_RS18205
uniprot id: C0QA30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

177437:HRM2 RS14100
gene id: 177437:HRM2_RS14100
uniprot id: C0QJC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS01260
gene id: 177437:HRM2_RS01260
uniprot id: C0QFI5
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

177437:HRM2 RS10655
gene id: 177437:HRM2_RS10655
uniprot id: C0QDI7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M38 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two zinc ions.
messages: Carboxylation allows a single lysine to coordinate two zinc ions.
messages: Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.
messages: Cytoplasm

177437:HRM2 RS08405
gene id: 177437:HRM2_RS08405
uniprot id: C0QAZ8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

177437:HRM2 RS16505
gene id: 177437:HRM2_RS16505
uniprot id: C0QMA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

177437:HRM2 RS11820
gene id: 177437:HRM2_RS11820
uniprot id: C0QFQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

177437:HRM2 RS16870
gene id: 177437:HRM2_RS16870
uniprot id: C0QMH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS11650
gene id: 177437:HRM2_RS11650
uniprot id: C0QEU9
names: Subcellular Location Annotation
messages: Cytoplasm

177437:HRM2 RS05340
gene id: 177437:HRM2_RS05340
uniprot id: C0QLA9
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

177437:HRM2 RS00180
gene id: 177437:HRM2_RS00180
uniprot id: C0QE46
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

177437:HRM2 RS22595
gene id: 177437:HRM2_RS22595
uniprot id: C0QG57
names: Similarity
messages: Belongs to the aspartokinase family.

177437:HRM2 RS05580
gene id: 177437:HRM2_RS05580
uniprot id: C0QLT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.
messages: Belongs to the GSP E family.
messages: Cell inner membrane

177437:HRM2 RS20255
gene id: 177437:HRM2_RS20255
uniprot id: C0QCE5
names: Similarity
messages: Belongs to the citrate synthase family.

177437:HRM2 RS11575
gene id: 177437:HRM2_RS11575
uniprot id: C0QET4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

177437:HRM2 RS15740
gene id: 177437:HRM2_RS15740
uniprot id: C0QLG5
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

177437:HRM2 RS24190
gene id: 177437:HRM2_RS24190
uniprot id: C0QIJ4
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS04795
gene id: 177437:HRM2_RS04795
uniprot id: C0QKL5
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

177437:HRM2 RS13390
gene id: 177437:HRM2_RS13390
uniprot id: C0QI60
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.
messages: Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).

177437:HRM2 RS07930
gene id: 177437:HRM2_RS07930
uniprot id: C0QAB9
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

177437:HRM2 RS04965
gene id: 177437:HRM2_RS04965
uniprot id: C0QL33
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS09350
gene id: 177437:HRM2_RS09350
uniprot id: C0QBW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

177437:HRM2 RS13105
gene id: 177437:HRM2_RS13105
uniprot id: C0QI04
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

177437:HRM2 RS18065
gene id: 177437:HRM2_RS18065
uniprot id: C0QA02
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

177437:HRM2 RS25545
gene id: 177437:HRM2_RS25545
uniprot id: C0QBP1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

177437:HRM2 RS19330
gene id: 177437:HRM2_RS19330
uniprot id: C0QBH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

177437:HRM2 RS11130
gene id: 177437:HRM2_RS11130
uniprot id: C0QEK2
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

177437:HRM2 RS22565
gene id: 177437:HRM2_RS22565
uniprot id: C0QG51
names: Similarity
messages: Belongs to the glutamine synthetase family.

177437:HRM2 RS18240
gene id: 177437:HRM2_RS18240
uniprot id: C0QA37
names: Function
names: Similarity
messages: Belongs to the FlgN family.
messages: Required for the efficient initiation of filament assembly.

177437:HRM2 RS02830
gene id: 177437:HRM2_RS02830
uniprot id: C0QIQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

177437:HRM2 RS23790
gene id: 177437:HRM2_RS23790
uniprot id: C0QIB4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

177437:HRM2 RS22155
gene id: 177437:HRM2_RS22155
uniprot id: C0QF49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

177437:HRM2 RS14755
gene id: 177437:HRM2_RS14755
uniprot id: C0QK44
names: Subcellular Location Annotation
messages: Periplasm

177437:HRM2 RS18855
gene id: 177437:HRM2_RS18855
uniprot id: C0QAU7
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS19975
gene id: 177437:HRM2_RS19975
uniprot id: C0QC92
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

177437:HRM2 RS01735
gene id: 177437:HRM2_RS01735
uniprot id: C0QGJ8
names: Similarity
messages: Belongs to the leucine-binding protein family.

177437:HRM2 RS17665
gene id: 177437:HRM2_RS17665
uniprot id: C0Q9D6
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS10715
gene id: 177437:HRM2_RS10715
uniprot id: C0QDJ9
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

177437:HRM2 RS24420
gene id: 177437:HRM2_RS24420
uniprot id: C0QIP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

177437:HRM2 RS05350
gene id: 177437:HRM2_RS05350
uniprot id: C0QLB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

177437:HRM2 RS19770
gene id: 177437:HRM2_RS19770
uniprot id: C0QC51
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

177437:HRM2 RS04175
gene id: 177437:HRM2_RS04175
uniprot id: C0QK93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS16010
gene id: 177437:HRM2_RS16010
uniprot id: C0QLL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

177437:HRM2 RS15255
gene id: 177437:HRM2_RS15255
uniprot id: C0QKT3
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

177437:HRM2 RS18275
gene id: 177437:HRM2_RS18275
uniprot id: C0QA44
names: Similarity
messages: Belongs to the type III secretion exporter family.

177437:HRM2 RS08880
gene id: 177437:HRM2_RS08880
uniprot id: C0QB87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

177437:HRM2 RS15655
gene id: 177437:HRM2_RS15655
uniprot id: C0QLE8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

177437:HRM2 RS06105
gene id: 177437:HRM2_RS06105
uniprot id: C0QM36
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

177437:HRM2 RS07775
gene id: 177437:HRM2_RS07775
uniprot id: C0QA85
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS11135
gene id: 177437:HRM2_RS11135
uniprot id: C0QEK3
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS06325
gene id: 177437:HRM2_RS06325
uniprot id: C0Q8P7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

177437:HRM2 RS09335
gene id: 177437:HRM2_RS09335
uniprot id: C0QBW1
names: Similarity
messages: Belongs to the peptidase M16 family.

177437:HRM2 RS15990
gene id: 177437:HRM2_RS15990
uniprot id: C0QLL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

177437:HRM2 RS00815
gene id: 177437:HRM2_RS00815
uniprot id: C0QF96
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

177437:HRM2 RS12080
gene id: 177437:HRM2_RS12080
uniprot id: C0QFV5
names: Similarity
messages: Belongs to the glycosyltransferase 1 family.

177437:HRM2 RS13665
gene id: 177437:HRM2_RS13665
uniprot id: C0QJ38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

177437:HRM2 RS23980
gene id: 177437:HRM2_RS23980
uniprot id: C0QIF1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

177437:HRM2 RS09805
gene id: 177437:HRM2_RS09805
uniprot id: C0QCK2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

177437:HRM2 RS17020
gene id: 177437:HRM2_RS17020
uniprot id: C0Q916
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

177437:HRM2 RS18950
gene id: 177437:HRM2_RS18950
uniprot id: C0QAW6
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

177437:HRM2 RS00450
gene id: 177437:HRM2_RS00450
uniprot id: C0QEA0
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS24565
gene id: 177437:HRM2_RS24565
uniprot id: C0QMM6
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

177437:HRM2 RS06745
gene id: 177437:HRM2_RS06745
uniprot id: C0Q8X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

177437:HRM2 RS22835
gene id: 177437:HRM2_RS22835
uniprot id: C0QG99
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

177437:HRM2 RS08370
gene id: 177437:HRM2_RS08370
uniprot id: C0QAZ3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

177437:HRM2 RS06980
gene id: 177437:HRM2_RS06980
uniprot id: C0Q9E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS01255
gene id: 177437:HRM2_RS01255
uniprot id: C0QFI4
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

177437:HRM2 RS17375
gene id: 177437:HRM2_RS17375
uniprot id: C0Q980
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

177437:HRM2 RS08975
gene id: 177437:HRM2_RS08975
uniprot id: C0QBA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

177437:HRM2 RS10095
gene id: 177437:HRM2_RS10095
uniprot id: C0QCR1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

177437:HRM2 RS14230
gene id: 177437:HRM2_RS14230
uniprot id: C0QJF4
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.
messages: Heterodimer of a large and a small subunit.

177437:HRM2 RS02465
gene id: 177437:HRM2_RS02465
uniprot id: C0QHQ4
names: Subcellular Location Annotation
messages: Cytoplasm

177437:HRM2 RS21755
gene id: 177437:HRM2_RS21755
uniprot id: C0QEW7
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ser-Ser-Gly.
messages: Cytoplasm

177437:HRM2 RS19555
gene id: 177437:HRM2_RS19555
uniprot id: C0QBM2
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

177437:HRM2 RS09685
gene id: 177437:HRM2_RS09685
uniprot id: C0QCH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

177437:HRM2 RS15275
gene id: 177437:HRM2_RS15275
uniprot id: C0QKT7
names: Similarity
messages: Belongs to the UPF0102 family.

177437:HRM2 RS13075
gene id: 177437:HRM2_RS13075
uniprot id: C0QHZ8
names: Similarity
messages: Belongs to the peptidase S8 family.

177437:HRM2 RS13535
gene id: 177437:HRM2_RS13535
uniprot id: C0QI89
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

177437:HRM2 RS08985
gene id: 177437:HRM2_RS08985
uniprot id: C0QBA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

177437:HRM2 RS03370
gene id: 177437:HRM2_RS03370
uniprot id: C0QJ19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

177437:HRM2 RS10335
gene id: 177437:HRM2_RS10335
uniprot id: C0QDC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

177437:HRM2 RS14155
gene id: 177437:HRM2_RS14155
uniprot id: C0QJD9
names: Similarity
messages: Belongs to the MotB family.

177437:HRM2 RS04480
gene id: 177437:HRM2_RS04480
uniprot id: C0QKF5
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS17605
gene id: 177437:HRM2_RS17605
uniprot id: C0Q9C4
names: Similarity
messages: Belongs to the universal stress protein A family.

177437:HRM2 RS06410
gene id: 177437:HRM2_RS06410
uniprot id: C0Q8R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS14340
gene id: 177437:HRM2_RS14340
uniprot id: C0QJW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

177437:HRM2 RS23800
gene id: 177437:HRM2_RS23800
uniprot id: C0QIB6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

177437:HRM2 RS05675
gene id: 177437:HRM2_RS05675
uniprot id: C0QLV5
names: Similarity
messages: Belongs to the peptidase S41A family.

177437:HRM2 RS06575
gene id: 177437:HRM2_RS06575
uniprot id: C0Q8U6
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

177437:HRM2 RS03235
gene id: 177437:HRM2_RS03235
uniprot id: C0QIZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

177437:HRM2 RS17470
gene id: 177437:HRM2_RS17470
uniprot id: C0Q997
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS18875
gene id: 177437:HRM2_RS18875
uniprot id: C0QAV0
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS21310
gene id: 177437:HRM2_RS21310
uniprot id: C0QDV6
names: Similarity
messages: Belongs to the peptidase S1 family.

177437:HRM2 RS02460
gene id: 177437:HRM2_RS02460
uniprot id: C0QHQ3
names: Similarity
messages: Belongs to the YggT family.

177437:HRM2 RS01085
gene id: 177437:HRM2_RS01085
uniprot id: C0QFF0
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

177437:HRM2 RS06100
gene id: 177437:HRM2_RS06100
uniprot id: C0QM35
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

177437:HRM2 RS09025
gene id: 177437:HRM2_RS09025
uniprot id: C0QBQ0
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS06750
gene id: 177437:HRM2_RS06750
uniprot id: C0Q8X7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

177437:HRM2 RS11195
gene id: 177437:HRM2_RS11195
uniprot id: C0QEL0
names: Subcellular Location Annotation
messages: Cytoplasm

177437:HRM2 RS06020
gene id: 177437:HRM2_RS06020
uniprot id: C0QM19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS21540
gene id: 177437:HRM2_RS21540
uniprot id: C0QE03
names: Similarity
messages: Belongs to the ABC transporter superfamily.

177437:HRM2 RS02815
gene id: 177437:HRM2_RS02815
uniprot id: C0QIQ4
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

177437:HRM2 RS23460
gene id: 177437:HRM2_RS23460
uniprot id: C0QHD5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

177437:HRM2 RS07980
gene id: 177437:HRM2_RS07980
uniprot id: C0QAD1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

177437:HRM2 RS04820
gene id: 177437:HRM2_RS04820
uniprot id: C0QKM0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

177437:HRM2 RS09410
gene id: 177437:HRM2_RS09410
uniprot id: C0QBX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

177437:HRM2 RS13635
gene id: 177437:HRM2_RS13635
uniprot id: C0QIA9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

177437:HRM2 RS03300
gene id: 177437:HRM2_RS03300
uniprot id: C0QJ05
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS10385
gene id: 177437:HRM2_RS10385
uniprot id: C0QDD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

177437:HRM2 RS19655
gene id: 177437:HRM2_RS19655
uniprot id: C0QBP3
names: Subcellular Location Annotation
messages: Nucleus

177437:HRM2 RS23600
gene id: 177437:HRM2_RS23600
uniprot id: C0QHG2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

177437:HRM2 RS15670
gene id: 177437:HRM2_RS15670
uniprot id: C0QLF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

177437:HRM2 RS13615
gene id: 177437:HRM2_RS13615
uniprot id: C0QIA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

177437:HRM2 RS16910
gene id: 177437:HRM2_RS16910
uniprot id: C0QMI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

177437:HRM2 RS05655
gene id: 177437:HRM2_RS05655
uniprot id: C0QLV1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS17850
gene id: 177437:HRM2_RS17850
uniprot id: C0Q9W3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

177437:HRM2 RS10160
gene id: 177437:HRM2_RS10160
uniprot id: C0QCS2
names: Similarity
messages: Belongs to the hemerythrin family.

177437:HRM2 RS15580
gene id: 177437:HRM2_RS15580
uniprot id: C0QKZ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

177437:HRM2 RS00555
gene id: 177437:HRM2_RS00555
uniprot id: C0QEC2
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS17070
gene id: 177437:HRM2_RS17070
uniprot id: C0Q927
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS08685
gene id: 177437:HRM2_RS08685
uniprot id: C0QB49
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

177437:HRM2 RS10780
gene id: 177437:HRM2_RS10780
uniprot id: C0QDL2
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS03890
gene id: 177437:HRM2_RS03890
uniprot id: C0QJQ4
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

177437:HRM2 RS10500
gene id: 177437:HRM2_RS10500
uniprot id: C0QDF6
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

177437:HRM2 RS12220
gene id: 177437:HRM2_RS12220
uniprot id: C0QFY4
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS05360
gene id: 177437:HRM2_RS05360
uniprot id: C0QLB3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

177437:HRM2 RS08045
gene id: 177437:HRM2_RS08045
uniprot id: C0QAE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

177437:HRM2 RS13905
gene id: 177437:HRM2_RS13905
uniprot id: C0QJ86
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

177437:HRM2 RS18350
gene id: 177437:HRM2_RS18350
uniprot id: C0QAJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

177437:HRM2 RS15610
gene id: 177437:HRM2_RS15610
uniprot id: C0QL03
names: Similarity
messages: Belongs to the peptidase M18 family.

177437:HRM2 RS06370
gene id: 177437:HRM2_RS06370
uniprot id: C0Q8Q4
names: Similarity
messages: Belongs to the Gfa family.

177437:HRM2 RS02990
gene id: 177437:HRM2_RS02990
uniprot id: C0QIT9
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

177437:HRM2 RS11360
gene id: 177437:HRM2_RS11360
uniprot id: C0QEP2
names: Similarity
messages: Belongs to the UPF0045 family.

177437:HRM2 RS18315
gene id: 177437:HRM2_RS18315
uniprot id: C0QA52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

177437:HRM2 RS23635
gene id: 177437:HRM2_RS23635
uniprot id: C0QHG9
names: Similarity
messages: Belongs to the glutamate synthase family.

177437:HRM2 RS02615
gene id: 177437:HRM2_RS02615
uniprot id: C0QHT4
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

177437:HRM2 RS18060
gene id: 177437:HRM2_RS18060
uniprot id: C0QA01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

177437:HRM2 RS17655
gene id: 177437:HRM2_RS17655
uniprot id: C0Q9D4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

177437:HRM2 RS10540
gene id: 177437:HRM2_RS10540
uniprot id: C0QDG4
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS24400
gene id: 177437:HRM2_RS24400
uniprot id: C0QIN8
names: Similarity
names: Subunit
messages: Belongs to the organic radical-activating enzymes family.
messages: Monomer.

177437:HRM2 RS00005
gene id: 177437:HRM2_RS00005
uniprot id: C0QD86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

177437:HRM2 RS14065
gene id: 177437:HRM2_RS14065
uniprot id: C0QJC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

177437:HRM2 RS12420
gene id: 177437:HRM2_RS12420
uniprot id: C0QGU3
names: Function
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

177437:HRM2 RS13465
gene id: 177437:HRM2_RS13465
uniprot id: C0QI75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

177437:HRM2 RS00640
gene id: 177437:HRM2_RS00640
uniprot id: C0QEE1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

177437:HRM2 RS12780
gene id: 177437:HRM2_RS12780
uniprot id: C0QH14
names: Similarity
messages: Belongs to the TlyA family.

177437:HRM2 RS03490
gene id: 177437:HRM2_RS03490
uniprot id: C0QJH9
names: Function
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

177437:HRM2 RS13870
gene id: 177437:HRM2_RS13870
uniprot id: C0QJ79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

177437:HRM2 RS01195
gene id: 177437:HRM2_RS01195
uniprot id: C0QFH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

177437:HRM2 RS02535
gene id: 177437:HRM2_RS02535
uniprot id: C0QHR8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

177437:HRM2 RS04705
gene id: 177437:HRM2_RS04705
uniprot id: C0QKJ7
names: Similarity
messages: Belongs to the UPF0270 family.

177437:HRM2 RS10880
gene id: 177437:HRM2_RS10880
uniprot id: C0QDN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane

177437:HRM2 RS02500
gene id: 177437:HRM2_RS02500
uniprot id: C0QHR1
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

177437:HRM2 RS05315
gene id: 177437:HRM2_RS05315
uniprot id: C0QLA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

177437:HRM2 RS06070
gene id: 177437:HRM2_RS06070
uniprot id: C0QM29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

177437:HRM2 RS08015
gene id: 177437:HRM2_RS08015
uniprot id: C0QAD8
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.

177437:HRM2 RS15660
gene id: 177437:HRM2_RS15660
uniprot id: C0QLE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

177437:HRM2 RS20115
gene id: 177437:HRM2_RS20115
uniprot id: C0QCB9
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.

177437:HRM2 RS24700
gene id: 177437:HRM2_RS24700
uniprot id: C0QMP8
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

177437:HRM2 RS13820
gene id: 177437:HRM2_RS13820
uniprot id: C0QJ69
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

177437:HRM2 RS12865
gene id: 177437:HRM2_RS12865
uniprot id: C0QH31
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS19020
gene id: 177437:HRM2_RS19020
uniprot id: C0QBB2
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.

177437:HRM2 RS13490
gene id: 177437:HRM2_RS13490
uniprot id: C0QI80
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

177437:HRM2 RS16885
gene id: 177437:HRM2_RS16885
uniprot id: C0QMH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS05320
gene id: 177437:HRM2_RS05320
uniprot id: C0QLA5
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

177437:HRM2 RS21775
gene id: 177437:HRM2_RS21775
uniprot id: C0QEX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS17865
gene id: 177437:HRM2_RS17865
uniprot id: C0Q9W6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

177437:HRM2 RS06655
gene id: 177437:HRM2_RS06655
uniprot id: C0Q8W0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

177437:HRM2 RS23965
gene id: 177437:HRM2_RS23965
uniprot id: C0QIE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

177437:HRM2 RS13565
gene id: 177437:HRM2_RS13565
uniprot id: C0QI95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 7 family.
messages: Homodimer.
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: Periplasm

177437:HRM2 RS22420
gene id: 177437:HRM2_RS22420
uniprot id: C0QG23
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

177437:HRM2 RS00655
gene id: 177437:HRM2_RS00655
uniprot id: C0QEE4
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

177437:HRM2 RS12435
gene id: 177437:HRM2_RS12435
uniprot id: C0QGU6
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

177437:HRM2 RS10990
gene id: 177437:HRM2_RS10990
uniprot id: C0QEH4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS15150
gene id: 177437:HRM2_RS15150
uniprot id: C0QKR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

177437:HRM2 RS04000
gene id: 177437:HRM2_RS04000
uniprot id: C0QJS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

177437:HRM2 RS18395
gene id: 177437:HRM2_RS18395
uniprot id: C0QAK3
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

177437:HRM2 RS13570
gene id: 177437:HRM2_RS13570
uniprot id: C0QI96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS20685
gene id: 177437:HRM2_RS20685
uniprot id: C0QD21
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

177437:HRM2 RS04945
gene id: 177437:HRM2_RS04945
uniprot id: C0QL29
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IcmF family.
messages: Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
messages: Homodimer.
messages: Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS17810
gene id: 177437:HRM2_RS17810
uniprot id: C0Q9V4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

177437:HRM2 RS18270
gene id: 177437:HRM2_RS18270
uniprot id: C0QA43
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

177437:HRM2 RS17415
gene id: 177437:HRM2_RS17415
uniprot id: C0Q988
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

177437:HRM2 RS11465
gene id: 177437:HRM2_RS11465
uniprot id: C0QER2
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

177437:HRM2 RS06415
gene id: 177437:HRM2_RS06415
uniprot id: C0Q8R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS22850
gene id: 177437:HRM2_RS22850
uniprot id: C0QGA2
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS05390
gene id: 177437:HRM2_RS05390
uniprot id: C0QLB8
names: Similarity
messages: Belongs to the FeoA family.
messages: Belongs to the Fur family.

177437:HRM2 RS11445
gene id: 177437:HRM2_RS11445
uniprot id: C0QEQ8
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

177437:HRM2 RS07975
gene id: 177437:HRM2_RS07975
uniprot id: C0QAD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyl-CoA hydrolase/transferase family.
messages: Coenzyme A-transferase that converts butyrate to butyryl-CoA.
messages: Cytoplasm

177437:HRM2 RS24325
gene id: 177437:HRM2_RS24325
uniprot id: C0QIM3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

177437:HRM2 RS01235
gene id: 177437:HRM2_RS01235
uniprot id: C0QFI0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

177437:HRM2 RS02735
gene id: 177437:HRM2_RS02735
uniprot id: C0QHV9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

177437:HRM2 RS17000
gene id: 177437:HRM2_RS17000
uniprot id: C0QMK0
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

177437:HRM2 RS17830
gene id: 177437:HRM2_RS17830
uniprot id: C0Q9V8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

177437:HRM2 RS22100
gene id: 177437:HRM2_RS22100
uniprot id: C0QF39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

177437:HRM2 RS00690
gene id: 177437:HRM2_RS00690
uniprot id: C0QEF0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

177437:HRM2 RS20055
gene id: 177437:HRM2_RS20055
uniprot id: C0QCA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

177437:HRM2 RS02320
gene id: 177437:HRM2_RS02320
uniprot id: C0QHM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

177437:HRM2 RS14335
gene id: 177437:HRM2_RS14335
uniprot id: C0QJW2
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

177437:HRM2 RS10855
gene id: 177437:HRM2_RS10855
uniprot id: C0QDM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

177437:HRM2 RS23615
gene id: 177437:HRM2_RS23615
uniprot id: C0QHG5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS13545
gene id: 177437:HRM2_RS13545
uniprot id: C0QI91
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

177437:HRM2 RS04880
gene id: 177437:HRM2_RS04880
uniprot id: C0QL17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
messages: Membrane

177437:HRM2 RS13360
gene id: 177437:HRM2_RS13360
uniprot id: C0QI54
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

177437:HRM2 RS06625
gene id: 177437:HRM2_RS06625
uniprot id: C0Q8V4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

177437:HRM2 RS01360
gene id: 177437:HRM2_RS01360
uniprot id: C0QFK4
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS22590
gene id: 177437:HRM2_RS22590
uniprot id: C0QG56
names: Function
names: Similarity
messages: Belongs to the CbiK family.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin.

177437:HRM2 RS00370
gene id: 177437:HRM2_RS00370
uniprot id: C0QE84
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS17785
gene id: 177437:HRM2_RS17785
uniprot id: C0Q9U8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

177437:HRM2 RS00025
gene id: 177437:HRM2_RS00025
uniprot id: C0QD90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

177437:HRM2 RS21210
gene id: 177437:HRM2_RS21210
uniprot id: C0QDT8
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

177437:HRM2 RS12460
gene id: 177437:HRM2_RS12460
uniprot id: C0QGV1
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS18790
gene id: 177437:HRM2_RS18790
uniprot id: C0QAT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS13920
gene id: 177437:HRM2_RS13920
uniprot id: C0QJ89
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

177437:HRM2 RS06300
gene id: 177437:HRM2_RS06300
uniprot id: C0Q8P2
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS04130
gene id: 177437:HRM2_RS04130
uniprot id: C0QJV2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

177437:HRM2 RS06120
gene id: 177437:HRM2_RS06120
uniprot id: C0QM39
names: Similarity
messages: Belongs to the thioredoxin family.

177437:HRM2 RS18415
gene id: 177437:HRM2_RS18415
uniprot id: C0QAK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

177437:HRM2 RS17055
gene id: 177437:HRM2_RS17055
uniprot id: C0Q923
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

177437:HRM2 RS15310
gene id: 177437:HRM2_RS15310
uniprot id: C0QKU4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

177437:HRM2 RS04530
gene id: 177437:HRM2_RS04530
uniprot id: C0QKG5
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

177437:HRM2 RS16400
gene id: 177437:HRM2_RS16400
uniprot id: C0QM80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

177437:HRM2 RS17930
gene id: 177437:HRM2_RS17930
uniprot id: C0Q9X9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

177437:HRM2 RS13425
gene id: 177437:HRM2_RS13425
uniprot id: C0QI67
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

177437:HRM2 RS16855
gene id: 177437:HRM2_RS16855
uniprot id: C0QMH1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

177437:HRM2 RS17855
gene id: 177437:HRM2_RS17855
uniprot id: C0Q9W4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

177437:HRM2 RS18095
gene id: 177437:HRM2_RS18095
uniprot id: C0QA06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

177437:HRM2 RS04535
gene id: 177437:HRM2_RS04535
uniprot id: C0QKG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

177437:HRM2 RS18405
gene id: 177437:HRM2_RS18405
uniprot id: C0QAK5
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

177437:HRM2 RS09425
gene id: 177437:HRM2_RS09425
uniprot id: C0QBY0
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS11600
gene id: 177437:HRM2_RS11600
uniprot id: C0QET9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

177437:HRM2 RS19865
gene id: 177437:HRM2_RS19865
uniprot id: C0QC70
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS10625
gene id: 177437:HRM2_RS10625
uniprot id: C0QDI1
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.

177437:HRM2 RS06060
gene id: 177437:HRM2_RS06060
uniprot id: C0QM27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS15470
gene id: 177437:HRM2_RS15470
uniprot id: C0QKX6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

177437:HRM2 RS16235
gene id: 177437:HRM2_RS16235
uniprot id: C0QLR1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

177437:HRM2 RS02645
gene id: 177437:HRM2_RS02645
uniprot id: C0QHU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

177437:HRM2 RS03090
gene id: 177437:HRM2_RS03090
uniprot id: C0QIV9
names: Similarity
messages: Belongs to the universal stress protein A family.

177437:HRM2 RS13380
gene id: 177437:HRM2_RS13380
uniprot id: C0QI58
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

177437:HRM2 RS03750
gene id: 177437:HRM2_RS03750
uniprot id: C0QJM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

177437:HRM2 RS23465
gene id: 177437:HRM2_RS23465
uniprot id: C0QHD6
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

177437:HRM2 RS17360
gene id: 177437:HRM2_RS17360
uniprot id: C0Q977
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

177437:HRM2 RS11325
gene id: 177437:HRM2_RS11325
uniprot id: C0QEN5
names: Similarity
messages: Belongs to the asparagine synthetase family.

177437:HRM2 RS03225
gene id: 177437:HRM2_RS03225
uniprot id: C0QIY9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS23095
gene id: 177437:HRM2_RS23095
uniprot id: C0QH71
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS18220
gene id: 177437:HRM2_RS18220
uniprot id: C0QA33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

177437:HRM2 RS20260
gene id: 177437:HRM2_RS20260
uniprot id: C0QCE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

177437:HRM2 RS24630
gene id: 177437:HRM2_RS24630
uniprot id: C0QMP1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

177437:HRM2 RS04805
gene id: 177437:HRM2_RS04805
uniprot id: C0QKL7
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: This protein is a Fe-Mo-cofactor biosynthetic component.

177437:HRM2 RS18650
gene id: 177437:HRM2_RS18650
uniprot id: C0QAQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

177437:HRM2 RS12240
gene id: 177437:HRM2_RS12240
uniprot id: C0QFY8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

177437:HRM2 RS00785
gene id: 177437:HRM2_RS00785
uniprot id: C0QEG8
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

177437:HRM2 RS06155
gene id: 177437:HRM2_RS06155
uniprot id: C0QM46
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

177437:HRM2 RS12455
gene id: 177437:HRM2_RS12455
uniprot id: C0QGV0
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS15315
gene id: 177437:HRM2_RS15315
uniprot id: C0QKU5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

177437:HRM2 RS01370
gene id: 177437:HRM2_RS01370
uniprot id: C0QFK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS09525
gene id: 177437:HRM2_RS09525
uniprot id: C0QC06
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

177437:HRM2 RS00600
gene id: 177437:HRM2_RS00600
uniprot id: C0QE56
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS16425
gene id: 177437:HRM2_RS16425
uniprot id: C0QM85
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.

177437:HRM2 RS09160
gene id: 177437:HRM2_RS09160
uniprot id: C0QBS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

177437:HRM2 RS03310
gene id: 177437:HRM2_RS03310
uniprot id: C0QJ07
names: Similarity
messages: Belongs to the P(II) protein family.

177437:HRM2 RS18105
gene id: 177437:HRM2_RS18105
uniprot id: C0QA08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

177437:HRM2 RS08355
gene id: 177437:HRM2_RS08355
uniprot id: C0QAZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

177437:HRM2 RS02820
gene id: 177437:HRM2_RS02820
uniprot id: C0QIQ5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

177437:HRM2 RS09020
gene id: 177437:HRM2_RS09020
uniprot id: C0QBP9
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

177437:HRM2 RS22480
gene id: 177437:HRM2_RS22480
uniprot id: C0QG34
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

177437:HRM2 RS05835
gene id: 177437:HRM2_RS05835
uniprot id: C0QLY6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

177437:HRM2 RS09890
gene id: 177437:HRM2_RS09890
uniprot id: C0QCL9
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS13115
gene id: 177437:HRM2_RS13115
uniprot id: C0QI07
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.
messages: The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
messages: The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.

177437:HRM2 RS11050
gene id: 177437:HRM2_RS11050
uniprot id: C0QEI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

177437:HRM2 RS13575
gene id: 177437:HRM2_RS13575
uniprot id: C0QI97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

177437:HRM2 RS13925
gene id: 177437:HRM2_RS13925
uniprot id: C0QJ90
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

177437:HRM2 RS17815
gene id: 177437:HRM2_RS17815
uniprot id: C0Q9V5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

177437:HRM2 RS03975
gene id: 177437:HRM2_RS03975
uniprot id: C0QJS1
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS02270
gene id: 177437:HRM2_RS02270
uniprot id: C0QHL7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

177437:HRM2 RS00010
gene id: 177437:HRM2_RS00010
uniprot id: C0QD87
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

177437:HRM2 RS00575
gene id: 177437:HRM2_RS00575
uniprot id: C0QEC5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

177437:HRM2 RS18340
gene id: 177437:HRM2_RS18340
uniprot id: C0QAJ2
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliO/MopB family.
messages: Cell membrane

177437:HRM2 RS15970
gene id: 177437:HRM2_RS15970
uniprot id: C0QLL1
names: Similarity
messages: Belongs to the glutamate synthase family.

177437:HRM2 RS17915
gene id: 177437:HRM2_RS17915
uniprot id: C0Q9X6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

177437:HRM2 RS18860
gene id: 177437:HRM2_RS18860
uniprot id: C0QAU8
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS13300
gene id: 177437:HRM2_RS13300
uniprot id: C0QI44
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

177437:HRM2 RS20220
gene id: 177437:HRM2_RS20220
uniprot id: C0QCD9
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

177437:HRM2 RS12090
gene id: 177437:HRM2_RS12090
uniprot id: C0QFV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

177437:HRM2 RS15520
gene id: 177437:HRM2_RS15520
uniprot id: C0QKY5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

177437:HRM2 RS14150
gene id: 177437:HRM2_RS14150
uniprot id: C0QJD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

177437:HRM2 RS17870
gene id: 177437:HRM2_RS17870
uniprot id: C0Q9W7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

177437:HRM2 RS21385
gene id: 177437:HRM2_RS21385
uniprot id: C0QDX3
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

177437:HRM2 RS04400
gene id: 177437:HRM2_RS04400
uniprot id: C0QKD9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

177437:HRM2 RS13940
gene id: 177437:HRM2_RS13940
uniprot id: C0QJ93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

177437:HRM2 RS04750
gene id: 177437:HRM2_RS04750
uniprot id: C0QKK6
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

177437:HRM2 RS01335
gene id: 177437:HRM2_RS01335
uniprot id: C0QFJ9
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

177437:HRM2 RS24430
gene id: 177437:HRM2_RS24430
uniprot id: C0QIP4
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

177437:HRM2 RS10150
gene id: 177437:HRM2_RS10150
uniprot id: C0QCS0
names: Subcellular Location Annotation
messages: Cytoplasm

177437:HRM2 RS04475
gene id: 177437:HRM2_RS04475
uniprot id: C0QKF4
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

177437:HRM2 RS21625
gene id: 177437:HRM2_RS21625
uniprot id: C0QE19
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

177437:HRM2 RS13645
gene id: 177437:HRM2_RS13645
uniprot id: C0QIB1
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

177437:HRM2 RS11815
gene id: 177437:HRM2_RS11815
uniprot id: C0QFQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

177437:HRM2 RS14515
gene id: 177437:HRM2_RS14515
uniprot id: C0QJZ8
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

177437:HRM2 RS17650
gene id: 177437:HRM2_RS17650
uniprot id: C0Q9D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

177437:HRM2 RS03270
gene id: 177437:HRM2_RS03270
uniprot id: C0QIZ9
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

177437:HRM2 RS00125
gene id: 177437:HRM2_RS00125
uniprot id: C0QE34
names: Subcellular Location Annotation
messages: Membrane

177437:HRM2 RS08730
gene id: 177437:HRM2_RS08730
uniprot id: C0QB58
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

177437:HRM2 RS17490
gene id: 177437:HRM2_RS17490
uniprot id: C0Q9A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS07455
gene id: 177437:HRM2_RS07455
uniprot id: C0Q9P1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

177437:HRM2 RS03940
gene id: 177437:HRM2_RS03940
uniprot id: C0QJR4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

177437:HRM2 RS01265
gene id: 177437:HRM2_RS01265
uniprot id: C0QFI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

177437:HRM2 RS23955
gene id: 177437:HRM2_RS23955
uniprot id: C0QIE6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

177437:HRM2 RS05020
gene id: 177437:HRM2_RS05020
uniprot id: C0QL44
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

177437:HRM2 RS22095
gene id: 177437:HRM2_RS22095
uniprot id: C0QF38
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

177437:HRM2 RS04540
gene id: 177437:HRM2_RS04540
uniprot id: C0QKG7
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

177437:HRM2 RS18255
gene id: 177437:HRM2_RS18255
uniprot id: C0QA40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

177437:HRM2 RS24335
gene id: 177437:HRM2_RS24335
uniprot id: C0QIM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

177437:HRM2 RS21450
gene id: 177437:HRM2_RS21450
uniprot id: C0QDY5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

177437:HRM2 RS21005
gene id: 177437:HRM2_RS21005
uniprot id: C0QDP7
names: Similarity
messages: Belongs to the UPF0166 family.

177437:HRM2 RS11895
gene id: 177437:HRM2_RS11895
uniprot id: C0QFS1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

177437:HRM2 RS20095
gene id: 177437:HRM2_RS20095
uniprot id: C0QCB5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

177437:HRM2 RS19390
gene id: 177437:HRM2_RS19390
uniprot id: C0QBI7
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

177437:HRM2 RS23065
gene id: 177437:HRM2_RS23065
uniprot id: C0QGE5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

177437:HRM2 RS08485
gene id: 177437:HRM2_RS08485
uniprot id: C0QB13
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.