171285:EXC46 RS02100
gene id: 171285:EXC46_RS02100
uniprot id: A0A449AV64
names: Similarity
messages: Belongs to the ABC transporter superfamily.

171285:EXC46 RS02775
gene id: 171285:EXC46_RS02775
uniprot id: A0A449AVV4
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

171285:EXC46 RS02885
gene id: 171285:EXC46_RS02885
uniprot id: A0A449AVZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

171285:EXC46 RS00975
gene id: 171285:EXC46_RS00975
uniprot id: A0A449AUM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

171285:EXC46 RS00040
gene id: 171285:EXC46_RS00040
uniprot id: A0A449AU51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

171285:EXC46 RS01150
gene id: 171285:EXC46_RS01150
uniprot id: A0A449AUN4
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

171285:EXC46 RS03140
gene id: 171285:EXC46_RS03140
uniprot id: A0A449AW52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

171285:EXC46 RS02425
gene id: 171285:EXC46_RS02425
uniprot id: A0A449AVJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

171285:EXC46 RS01960
gene id: 171285:EXC46_RS01960
uniprot id: A0A449AV43
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

171285:EXC46 RS01060
gene id: 171285:EXC46_RS01060
uniprot id: A0A449AUM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

171285:EXC46 RS02770
gene id: 171285:EXC46_RS02770
uniprot id: A0A449AVY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

171285:EXC46 RS01095
gene id: 171285:EXC46_RS01095
uniprot id: A0A449AUP9
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

171285:EXC46 RS00190
gene id: 171285:EXC46_RS00190
uniprot id: A0A449AU78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

171285:EXC46 RS00475
gene id: 171285:EXC46_RS00475
uniprot id: A0A449AUE3
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

171285:EXC46 RS00895
gene id: 171285:EXC46_RS00895
uniprot id: A0A449AUM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

171285:EXC46 RS01955
gene id: 171285:EXC46_RS01955
uniprot id: A0A449AV76
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171285:EXC46 RS03185
gene id: 171285:EXC46_RS03185
uniprot id: A0A449AWA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

171285:EXC46 RS01570
gene id: 171285:EXC46_RS01570
uniprot id: A0A449AUW5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171285:EXC46 RS00430
gene id: 171285:EXC46_RS00430
uniprot id: A0A449AU92
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

171285:EXC46 RS00115
gene id: 171285:EXC46_RS00115
uniprot id: A0A449AU27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

171285:EXC46 RS03565
gene id: 171285:EXC46_RS03565
uniprot id: A0A449AWK2
names: Similarity
messages: Belongs to the peptidase M17 family.

171285:EXC46 RS00930
gene id: 171285:EXC46_RS00930
uniprot id: A0A449AUK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

171285:EXC46 RS01555
gene id: 171285:EXC46_RS01555
uniprot id: A0A449AUZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

171285:EXC46 RS02105
gene id: 171285:EXC46_RS02105
uniprot id: A0A449AVA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

171285:EXC46 RS00355
gene id: 171285:EXC46_RS00355
uniprot id: A0A449AUA9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

171285:EXC46 RS02445
gene id: 171285:EXC46_RS02445
uniprot id: A0A449AVJ9
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

171285:EXC46 RS00815
gene id: 171285:EXC46_RS00815
uniprot id: A0A449AUJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

171285:EXC46 RS01170
gene id: 171285:EXC46_RS01170
uniprot id: A0A449AUR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

171285:EXC46 RS02910
gene id: 171285:EXC46_RS02910
uniprot id: A0A449AW08
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171285:EXC46 RS02040
gene id: 171285:EXC46_RS02040
uniprot id: A0A449AV57
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

171285:EXC46 RS02475
gene id: 171285:EXC46_RS02475
uniprot id: A0A449AVK9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

171285:EXC46 RS01265
gene id: 171285:EXC46_RS01265
uniprot id: A0A449AUR4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

171285:EXC46 RS02080
gene id: 171285:EXC46_RS02080
uniprot id: A0A449AV82
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171285:EXC46 RS00785
gene id: 171285:EXC46_RS00785
uniprot id: A0A449AUG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

171285:EXC46 RS00925
gene id: 171285:EXC46_RS00925
uniprot id: A0A449AUL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

171285:EXC46 RS00600
gene id: 171285:EXC46_RS00600
uniprot id: A0A449AUF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

171285:EXC46 RS03315
gene id: 171285:EXC46_RS03315
uniprot id: A0A449AWH0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

171285:EXC46 RS01385
gene id: 171285:EXC46_RS01385
uniprot id: A0A449AUV8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

171285:EXC46 RS00480
gene id: 171285:EXC46_RS00480
uniprot id: A0A449AUA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

171285:EXC46 RS03505
gene id: 171285:EXC46_RS03505
uniprot id: A0A449AWT1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

171285:EXC46 RS03100
gene id: 171285:EXC46_RS03100
uniprot id: A0A449AW79
names: Subcellular Location Annotation
messages: Membrane

171285:EXC46 RS01215
gene id: 171285:EXC46_RS01215
uniprot id: A0A449AUU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

171285:EXC46 RS01585
gene id: 171285:EXC46_RS01585
uniprot id: A0A449AUZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

171285:EXC46 RS00440
gene id: 171285:EXC46_RS00440
uniprot id: A0A449AUC8
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

171285:EXC46 RS03175
gene id: 171285:EXC46_RS03175
uniprot id: A0A449AWE7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

171285:EXC46 RS00150
gene id: 171285:EXC46_RS00150
uniprot id: A0A449AU83
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171285:EXC46 RS02065
gene id: 171285:EXC46_RS02065
uniprot id: A0A449AVA7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

171285:EXC46 RS01235
gene id: 171285:EXC46_RS01235
uniprot id: A0A449AUS6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

171285:EXC46 RS03515
gene id: 171285:EXC46_RS03515
uniprot id: A0A449AWJ2
names: Similarity
messages: Belongs to the thioredoxin family.

171285:EXC46 RS01590
gene id: 171285:EXC46_RS01590
uniprot id: A0A449AUW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

171285:EXC46 RS00935
gene id: 171285:EXC46_RS00935
uniprot id: A0A449AUM2
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

171285:EXC46 RS00610
gene id: 171285:EXC46_RS00610
uniprot id: A0A449AUE6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

171285:EXC46 RS01225
gene id: 171285:EXC46_RS01225
uniprot id: A0A449AUP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

171285:EXC46 RS02465
gene id: 171285:EXC46_RS02465
uniprot id: A0A449AVJ7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

171285:EXC46 RS00105
gene id: 171285:EXC46_RS00105
uniprot id: A0A449AU31
names: Similarity
messages: Belongs to the peptidase M13 family.

171285:EXC46 RS02790
gene id: 171285:EXC46_RS02790
uniprot id: A0A449AVV0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

171285:EXC46 RS02165
gene id: 171285:EXC46_RS02165
uniprot id: A0A449AVC6
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

171285:EXC46 RS01610
gene id: 171285:EXC46_RS01610
uniprot id: A0A449AV01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

171285:EXC46 RS00155
gene id: 171285:EXC46_RS00155
uniprot id: A0A449AU41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

171285:EXC46 RS00235
gene id: 171285:EXC46_RS00235
uniprot id: A0A449AU49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

171285:EXC46 RS03015
gene id: 171285:EXC46_RS03015
uniprot id: A0A449AW49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

171285:EXC46 RS03355
gene id: 171285:EXC46_RS03355
uniprot id: A0A449AWL7
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

171285:EXC46 RS01270
gene id: 171285:EXC46_RS01270
uniprot id: A0A449AUV2
names: Subcellular Location Annotation
messages: Membrane

171285:EXC46 RS03135
gene id: 171285:EXC46_RS03135
uniprot id: A0A449AWD7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

171285:EXC46 RS02000
gene id: 171285:EXC46_RS02000
uniprot id: A0A449AV47
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

171285:EXC46 RS02760
gene id: 171285:EXC46_RS02760
uniprot id: A0A449AVT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

171285:EXC46 RS02955
gene id: 171285:EXC46_RS02955
uniprot id: A0A449AW53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

171285:EXC46 RS01830
gene id: 171285:EXC46_RS01830
uniprot id: A0A449AV45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

171285:EXC46 RS01335
gene id: 171285:EXC46_RS01335
uniprot id: A0A449AUU7
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

171285:EXC46 RS00060
gene id: 171285:EXC46_RS00060
uniprot id: A0A449AU72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

171285:EXC46 RS00715
gene id: 171285:EXC46_RS00715
uniprot id: A0A449AUF3
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

171285:EXC46 RS00870
gene id: 171285:EXC46_RS00870
uniprot id: A0A449AUK6
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

171285:EXC46 RS02140
gene id: 171285:EXC46_RS02140
uniprot id: A0A449AV75
names: Similarity
messages: Belongs to the LacAB/RpiB family.

171285:EXC46 RS03220
gene id: 171285:EXC46_RS03220
uniprot id: A0A449AWD9
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

171285:EXC46 RS00410
gene id: 171285:EXC46_RS00410
uniprot id: A0A449AUA7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

171285:EXC46 RS00825
gene id: 171285:EXC46_RS00825
uniprot id: A0A449AUI4
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

171285:EXC46 RS00490
gene id: 171285:EXC46_RS00490
uniprot id: A0A449AUD6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

171285:EXC46 RS02875
gene id: 171285:EXC46_RS02875
uniprot id: A0A449AW11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

171285:EXC46 RS00560
gene id: 171285:EXC46_RS00560
uniprot id: A0A449AUF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

171285:EXC46 RS02745
gene id: 171285:EXC46_RS02745
uniprot id: A0A449AVW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

171285:EXC46 RS00050
gene id: 171285:EXC46_RS00050
uniprot id: A0A449AU64
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

171285:EXC46 RS00085
gene id: 171285:EXC46_RS00085
uniprot id: A0A449AU60
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

171285:EXC46 RS02765
gene id: 171285:EXC46_RS02765
uniprot id: A0A449AVX1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

171285:EXC46 RS02030
gene id: 171285:EXC46_RS02030
uniprot id: A0A449AV72
names: Subcellular Location Annotation
messages: Membrane

171285:EXC46 RS00665
gene id: 171285:EXC46_RS00665
uniprot id: A0A449AUI3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171285:EXC46 RS01435
gene id: 171285:EXC46_RS01435
uniprot id: A0A449AUX9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

171285:EXC46 RS00960
gene id: 171285:EXC46_RS00960
uniprot id: A0A449AUN7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

171285:EXC46 RS02160
gene id: 171285:EXC46_RS02160
uniprot id: A0A449AV90
names: Subcellular Location Annotation
messages: Membrane

171285:EXC46 RS03660
gene id: 171285:EXC46_RS03660
uniprot id: A0A449AWY5
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

171285:EXC46 RS02920
gene id: 171285:EXC46_RS02920
uniprot id: A0A449AVY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

171285:EXC46 RS00670
gene id: 171285:EXC46_RS00670
uniprot id: A0A449AUE2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171285:EXC46 RS00655
gene id: 171285:EXC46_RS00655
uniprot id: A0A449AUE8
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

171285:EXC46 RS02455
gene id: 171285:EXC46_RS02455
uniprot id: A0A449AVH0
names: Subcellular Location Annotation
messages: Membrane

171285:EXC46 RS01580
gene id: 171285:EXC46_RS01580
uniprot id: A0A449AV10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

171285:EXC46 RS01370
gene id: 171285:EXC46_RS01370
uniprot id: A0A449AUX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

171285:EXC46 RS03605
gene id: 171285:EXC46_RS03605
uniprot id: A0A449AWR8
names: Similarity
messages: Belongs to the XFP family.

171285:EXC46 RS01520
gene id: 171285:EXC46_RS01520
uniprot id: A0A449AUV4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

171285:EXC46 RS01065
gene id: 171285:EXC46_RS01065
uniprot id: A0A449AUR0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

171285:EXC46 RS01025
gene id: 171285:EXC46_RS01025
uniprot id: A0A449AUN2
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

171285:EXC46 RS02795
gene id: 171285:EXC46_RS02795
uniprot id: A0A449AVU7
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171285:EXC46 RS02060
gene id: 171285:EXC46_RS02060
uniprot id: A0A449AV68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

171285:EXC46 RS01905
gene id: 171285:EXC46_RS01905
uniprot id: A0A449AV34
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

171285:EXC46 RS01160
gene id: 171285:EXC46_RS01160
uniprot id: A0A449AUP6
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

171285:EXC46 RS03205
gene id: 171285:EXC46_RS03205
uniprot id: A0A449AW74
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

171285:EXC46 RS00170
gene id: 171285:EXC46_RS00170
uniprot id: A0A449AU80
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

171285:EXC46 RS01600
gene id: 171285:EXC46_RS01600
uniprot id: A0A449AV02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

171285:EXC46 RS02880
gene id: 171285:EXC46_RS02880
uniprot id: A0A449AW20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

171285:EXC46 RS03115
gene id: 171285:EXC46_RS03115
uniprot id: A0A449AW84
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

171285:EXC46 RS00080
gene id: 171285:EXC46_RS00080
uniprot id: A0A449AU17
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

171285:EXC46 RS03200
gene id: 171285:EXC46_RS03200
uniprot id: A0A449AWF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

171285:EXC46 RS00710
gene id: 171285:EXC46_RS00710
uniprot id: A0A449AUJ7
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

171285:EXC46 RS01220
gene id: 171285:EXC46_RS01220
uniprot id: A0A449AUS9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

171285:EXC46 RS00140
gene id: 171285:EXC46_RS00140
uniprot id: A0A449AU67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

171285:EXC46 RS02740
gene id: 171285:EXC46_RS02740
uniprot id: A0A449AVW6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

171285:EXC46 RS00915
gene id: 171285:EXC46_RS00915
uniprot id: A0A449AUI6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

171285:EXC46 RS01950
gene id: 171285:EXC46_RS01950
uniprot id: A0A449AV36
names: Similarity
messages: Belongs to the ClpA/ClpB family.

171285:EXC46 RS01530
gene id: 171285:EXC46_RS01530
uniprot id: A0A449AUW6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

171285:EXC46 RS00205
gene id: 171285:EXC46_RS00205
uniprot id: A0A449AU93
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

171285:EXC46 RS02495
gene id: 171285:EXC46_RS02495
uniprot id: A0A449AVG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

171285:EXC46 RS02360
gene id: 171285:EXC46_RS02360
uniprot id: A0A449AVC2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

171285:EXC46 RS00845
gene id: 171285:EXC46_RS00845
uniprot id: A0A449AUI1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

171285:EXC46 RS03610
gene id: 171285:EXC46_RS03610
uniprot id: A0A449AWS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

171285:EXC46 RS01915
gene id: 171285:EXC46_RS01915
uniprot id: A0A449AV54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

171285:EXC46 RS03480
gene id: 171285:EXC46_RS03480
uniprot id: A0A449AWI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

171285:EXC46 RS00035
gene id: 171285:EXC46_RS00035
uniprot id: A0A449AU47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

171285:EXC46 RS00890
gene id: 171285:EXC46_RS00890
uniprot id: A0A449AUH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

171285:EXC46 RS01865
gene id: 171285:EXC46_RS01865
uniprot id: A0A449AV40
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

171285:EXC46 RS03440
gene id: 171285:EXC46_RS03440
uniprot id: A0A449AWL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

171285:EXC46 RS01550
gene id: 171285:EXC46_RS01550
uniprot id: A0A449AUY2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

171285:EXC46 RS02035
gene id: 171285:EXC46_RS02035
uniprot id: A0A449AV74
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.

171285:EXC46 RS03250
gene id: 171285:EXC46_RS03250
uniprot id: A0A449AWH8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

171285:EXC46 RS03485
gene id: 171285:EXC46_RS03485
uniprot id: A0A449AWM2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

171285:EXC46 RS02075
gene id: 171285:EXC46_RS02075
uniprot id: A0A449AV51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

171285:EXC46 RS02305
gene id: 171285:EXC46_RS02305
uniprot id: A0A449AVB2
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.

171285:EXC46 RS01595
gene id: 171285:EXC46_RS01595
uniprot id: A0A449AUZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

171285:EXC46 RS00125
gene id: 171285:EXC46_RS00125
uniprot id: A0A449AU74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

171285:EXC46 RS01050
gene id: 171285:EXC46_RS01050
uniprot id: A0A449AUR2
names: Subcellular Location Annotation
messages: Membrane

171285:EXC46 RS03085
gene id: 171285:EXC46_RS03085
uniprot id: A0A449AW94
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

171285:EXC46 RS00220
gene id: 171285:EXC46_RS00220
uniprot id: A0A449AU50
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

171285:EXC46 RS00340
gene id: 171285:EXC46_RS00340
uniprot id: A0A449AUB5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

171285:EXC46 RS00275
gene id: 171285:EXC46_RS00275
uniprot id: A0A449AUA0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

171285:EXC46 RS03655
gene id: 171285:EXC46_RS03655
uniprot id: A0A449AWU0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.

171285:EXC46 RS00420
gene id: 171285:EXC46_RS00420
uniprot id: A0A449AU88
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

171285:EXC46 RS00435
gene id: 171285:EXC46_RS00435
uniprot id: A0A449AUD4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

171285:EXC46 RS00585
gene id: 171285:EXC46_RS00585
uniprot id: A0A449AUG5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

171285:EXC46 RS02380
gene id: 171285:EXC46_RS02380
uniprot id: A0A449AVI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

171285:EXC46 RS02430
gene id: 171285:EXC46_RS02430
uniprot id: A0A449AVK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

171285:EXC46 RS00555
gene id: 171285:EXC46_RS00555
uniprot id: A0A449AUG0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

171285:EXC46 RS03540
gene id: 171285:EXC46_RS03540
uniprot id: A0A449AWP7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

171285:EXC46 RS00045
gene id: 171285:EXC46_RS00045
uniprot id: A0A449AU36
names: Caution
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

171285:EXC46 RS00025
gene id: 171285:EXC46_RS00025
uniprot id: A0A449AU56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).

171285:EXC46 RS02545
gene id: 171285:EXC46_RS02545
uniprot id: A0A449AVP9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

171285:EXC46 RS03350
gene id: 171285:EXC46_RS03350
uniprot id: A0A449AWI7
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

171285:EXC46 RS01880
gene id: 171285:EXC46_RS01880
uniprot id: A0A449AV60
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171285:EXC46 RS01480
gene id: 171285:EXC46_RS01480
uniprot id: A0A449AUV3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

171285:EXC46 RS03020
gene id: 171285:EXC46_RS03020
uniprot id: A0A449AW21
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

171285:EXC46 RS01090
gene id: 171285:EXC46_RS01090
uniprot id: A0A449AUN0
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

171285:EXC46 RS02460
gene id: 171285:EXC46_RS02460
uniprot id: A0A449AVJ0
names: Similarity
messages: Belongs to the peptidase S16 family.

171285:EXC46 RS00380
gene id: 171285:EXC46_RS00380
uniprot id: A0A449AU81
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

171285:EXC46 RS00280
gene id: 171285:EXC46_RS00280
uniprot id: A0A449AUA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

171285:EXC46 RS00660
gene id: 171285:EXC46_RS00660
uniprot id: A0A449AUI8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

171285:EXC46 RS02930
gene id: 171285:EXC46_RS02930
uniprot id: A0A449AW41
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

171285:EXC46 RS01990
gene id: 171285:EXC46_RS01990
uniprot id: A0A449AV48
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

171285:EXC46 RS03150
gene id: 171285:EXC46_RS03150
uniprot id: A0A449AWB4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

171285:EXC46 RS00950
gene id: 171285:EXC46_RS00950
uniprot id: A0A449AUK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

171285:EXC46 RS00640
gene id: 171285:EXC46_RS00640
uniprot id: A0A449AUF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.

171285:EXC46 RS02115
gene id: 171285:EXC46_RS02115
uniprot id: A0A449AVB7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

171285:EXC46 RS02090
gene id: 171285:EXC46_RS02090
uniprot id: A0A449AV66
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

171285:EXC46 RS00185
gene id: 171285:EXC46_RS00185
uniprot id: A0A449AU39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta sliding clamp family.
messages: Cytoplasm

171285:EXC46 RS03120
gene id: 171285:EXC46_RS03120
uniprot id: A0A449AW83
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

171285:EXC46 RS01295
gene id: 171285:EXC46_RS01295
uniprot id: A0A449AUU1
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

171285:EXC46 RS00920
gene id: 171285:EXC46_RS00920
uniprot id: A0A449AUL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

171285:EXC46 RS03435
gene id: 171285:EXC46_RS03435
uniprot id: A0A449AWK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

171285:EXC46 RS01575
gene id: 171285:EXC46_RS01575
uniprot id: A0A449AUX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane

171285:EXC46 RS01195
gene id: 171285:EXC46_RS01195
uniprot id: A0A449AUS3
names: Subcellular Location Annotation
messages: Membrane

171285:EXC46 RS00470
gene id: 171285:EXC46_RS00470
uniprot id: A0A449AUE5
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

171285:EXC46 RS00160
gene id: 171285:EXC46_RS00160
uniprot id: A0A449AU90
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171285:EXC46 RS02095
gene id: 171285:EXC46_RS02095
uniprot id: A0A449AV99
names: Similarity
messages: Belongs to the ABC transporter superfamily.

171285:EXC46 RS01165
gene id: 171285:EXC46_RS01165
uniprot id: A0A449AUT3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

171285:EXC46 RS00360
gene id: 171285:EXC46_RS00360
uniprot id: A0A449AU97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

171285:EXC46 RS01995
gene id: 171285:EXC46_RS01995
uniprot id: A0A449AV79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

171285:EXC46 RS03195
gene id: 171285:EXC46_RS03195
uniprot id: A0A449AWC8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

171285:EXC46 RS01085
gene id: 171285:EXC46_RS01085
uniprot id: A0A449AUP1
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

171285:EXC46 RS03145
gene id: 171285:EXC46_RS03145
uniprot id: A0A449AW96
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

171285:EXC46 RS03390
gene id: 171285:EXC46_RS03390
uniprot id: A0A449AWI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

171285:EXC46 RS01390
gene id: 171285:EXC46_RS01390
uniprot id: A0A449AUR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

171285:EXC46 RS02815
gene id: 171285:EXC46_RS02815
uniprot id: A0A449AVW1
names: Subcellular Location Annotation
messages: cytosol

171285:EXC46 RS02490
gene id: 171285:EXC46_RS02490
uniprot id: A0A449AVM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

171285:EXC46 RS01890
gene id: 171285:EXC46_RS01890
uniprot id: A0A449AV26
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

171285:EXC46 RS01185
gene id: 171285:EXC46_RS01185
uniprot id: A0A449AUR6
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

171285:EXC46 RS02950
gene id: 171285:EXC46_RS02950
uniprot id: A0A449AW40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

171285:EXC46 RS00905
gene id: 171285:EXC46_RS00905
uniprot id: A0A449AUM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

171285:EXC46 RS02125
gene id: 171285:EXC46_RS02125
uniprot id: A0A449AV61
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

171285:EXC46 RS00580
gene id: 171285:EXC46_RS00580
uniprot id: A0A449AUH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

171285:EXC46 RS02300
gene id: 171285:EXC46_RS02300
uniprot id: A0A449AVE7
names: Subcellular Location Annotation
messages: Membrane

171285:EXC46 RS00620
gene id: 171285:EXC46_RS00620
uniprot id: A0A449AUC9
names: Similarity
messages: Belongs to the pyruvate kinase family.

171285:EXC46 RS00900
gene id: 171285:EXC46_RS00900
uniprot id: A0A449AUJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

171285:EXC46 RS03190
gene id: 171285:EXC46_RS03190
uniprot id: A0A449AWC6
names: Subcellular Location Annotation
messages: Membrane

171285:EXC46 RS00200
gene id: 171285:EXC46_RS00200
uniprot id: A0A449AU65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

171285:EXC46 RS00595
gene id: 171285:EXC46_RS00595
uniprot id: A0A449AUC2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

171285:EXC46 RS00695
gene id: 171285:EXC46_RS00695
uniprot id: A0A449AUF0
names: Subcellular Location Annotation
messages: Membrane

171285:EXC46 RS00705
gene id: 171285:EXC46_RS00705
uniprot id: A0A449AUG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

171285:EXC46 RS02700
gene id: 171285:EXC46_RS02700
uniprot id: A0A449AVT2
names: Similarity
messages: Belongs to the Nudix hydrolase family.

171285:EXC46 RS00940
gene id: 171285:EXC46_RS00940
uniprot id: A0A449AUI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

171285:EXC46 RS01930
gene id: 171285:EXC46_RS01930
uniprot id: A0A449AV55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

171285:EXC46 RS00605
gene id: 171285:EXC46_RS00605
uniprot id: A0A449AUF4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

171285:EXC46 RS00365
gene id: 171285:EXC46_RS00365
uniprot id: A0A449AUC3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

171285:EXC46 RS02915
gene id: 171285:EXC46_RS02915
uniprot id: A0A449AW02
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

171285:EXC46 RS03130
gene id: 171285:EXC46_RS03130
uniprot id: A0A449AWA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

171285:EXC46 RS00345
gene id: 171285:EXC46_RS00345
uniprot id: A0A449AU73
names: Similarity
messages: Belongs to the ABC transporter superfamily.

171285:EXC46 RS00910
gene id: 171285:EXC46_RS00910
uniprot id: A0A449AUM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

171285:EXC46 RS02135
gene id: 171285:EXC46_RS02135
uniprot id: A0A449AV97
names: Similarity
messages: Belongs to the ABC transporter superfamily.

171285:EXC46 RS01855
gene id: 171285:EXC46_RS01855
uniprot id: A0A449AV46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

171285:EXC46 RS03590
gene id: 171285:EXC46_RS03590
uniprot id: A0A449AWL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm

171285:EXC46 RS02705
gene id: 171285:EXC46_RS02705
uniprot id: A0A449AVR0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

171285:EXC46 RS01605
gene id: 171285:EXC46_RS01605
uniprot id: A0A449AUX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

171285:EXC46 RS02120
gene id: 171285:EXC46_RS02120
uniprot id: A0A449AV93
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

171285:EXC46 RS02735
gene id: 171285:EXC46_RS02735
uniprot id: A0A449AVS5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171285:EXC46 RS03475
gene id: 171285:EXC46_RS03475
uniprot id: A0A449AWS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

171285:EXC46 RS01325
gene id: 171285:EXC46_RS01325
uniprot id: A0A449AUS1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

171285:EXC46 RS00120
gene id: 171285:EXC46_RS00120
uniprot id: A0A449AU70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

171285:EXC46 RS03340
gene id: 171285:EXC46_RS03340
uniprot id: A0A449AWG0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

171285:EXC46 RS03125
gene id: 171285:EXC46_RS03125
uniprot id: A0A449AWA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

171285:EXC46 RS00970
gene id: 171285:EXC46_RS00970
uniprot id: A0A449AUM7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

171285:EXC46 RS03080
gene id: 171285:EXC46_RS03080
uniprot id: A0A449AW44
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

171285:EXC46 RS03635
gene id: 171285:EXC46_RS03635
uniprot id: A0A449AWT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

171285:EXC46 RS00865
gene id: 171285:EXC46_RS00865
uniprot id: A0A449AUH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

171285:EXC46 RS01005
gene id: 171285:EXC46_RS01005
uniprot id: A0A449AUQ2
names: Similarity
messages: Belongs to the ATPase gamma chain family.

171285:EXC46 RS01070
gene id: 171285:EXC46_RS01070
uniprot id: A0A449AUQ4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

171285:EXC46 RS00945
gene id: 171285:EXC46_RS00945
uniprot id: A0A449AUP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

171285:EXC46 RS03360
gene id: 171285:EXC46_RS03360
uniprot id: A0A449AWD1
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

171285:EXC46 RS02715
gene id: 171285:EXC46_RS02715
uniprot id: A0A449AVU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

171285:EXC46 RS01840
gene id: 171285:EXC46_RS01840
uniprot id: A0A449AV58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

171285:EXC46 RS03715
gene id: 171285:EXC46_RS03715
uniprot id: A0A449AUE4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

171285:EXC46 RS01375
gene id: 171285:EXC46_RS01375
uniprot id: A0A449AUT5
names: Similarity
messages: Belongs to the RibF family.

171285:EXC46 RS02485
gene id: 171285:EXC46_RS02485
uniprot id: A0A449AVL2
names: Subcellular Location Annotation
messages: Membrane

171285:EXC46 RS00680
gene id: 171285:EXC46_RS00680
uniprot id: A0A449AUH5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

171285:EXC46 RS03240
gene id: 171285:EXC46_RS03240
uniprot id: A0A449AWE4
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

171285:EXC46 RS02980
gene id: 171285:EXC46_RS02980
uniprot id: A0A449AW62
names: Subcellular Location Annotation
messages: Membrane

171285:EXC46 RS01910
gene id: 171285:EXC46_RS01910
uniprot id: A0A449AV73
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecU family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.

171285:EXC46 RS01635
gene id: 171285:EXC46_RS01635
uniprot id: A0A449AUY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

171285:EXC46 RS02085
gene id: 171285:EXC46_RS02085
uniprot id: A0A449AV83
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

171285:EXC46 RS03645
gene id: 171285:EXC46_RS03645
uniprot id: A0A449AWN6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

171285:EXC46 RS00965
gene id: 171285:EXC46_RS00965
uniprot id: A0A449AUJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

171285:EXC46 RS02975
gene id: 171285:EXC46_RS02975
uniprot id: A0A449AW51
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

171285:EXC46 RS00955
gene id: 171285:EXC46_RS00955
uniprot id: A0A449AUN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

171285:EXC46 RS01405
gene id: 171285:EXC46_RS01405
uniprot id: A0A449AUT7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

171285:EXC46 RS02055
gene id: 171285:EXC46_RS02055
uniprot id: A0A449AV96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

171285:EXC46 RS03235
gene id: 171285:EXC46_RS03235
uniprot id: A0A449AWC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

171285:EXC46 RS00720
gene id: 171285:EXC46_RS00720
uniprot id: A0A449AUI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

171285:EXC46 RS03180
gene id: 171285:EXC46_RS03180
uniprot id: A0A449AW63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

171285:EXC46 RS00285
gene id: 171285:EXC46_RS00285
uniprot id: A0A449AU62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Cell membrane
messages: Membrane

171285:EXC46 RS02935
gene id: 171285:EXC46_RS02935
uniprot id: A0A449AW19
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

171285:EXC46 RS02670
gene id: 171285:EXC46_RS02670
uniprot id: A0A449AVS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

171285:EXC46 RS00400
gene id: 171285:EXC46_RS00400
uniprot id: A0A449AUB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

171285:EXC46 RS01075
gene id: 171285:EXC46_RS01075
uniprot id: A0A449AUL4
names: Similarity
messages: Belongs to the peptidase M13 family.

171285:EXC46 RS00270
gene id: 171285:EXC46_RS00270
uniprot id: A0A449AU59
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

171285:EXC46 RS02890
gene id: 171285:EXC46_RS02890
uniprot id: A0A449AVZ2
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

171285:EXC46 RS01540
gene id: 171285:EXC46_RS01540
uniprot id: A0A449AUY7
names: Subcellular Location Annotation
messages: Membrane