163003:CL1 RS08235
gene id: 163003:CL1_RS08235
uniprot id: I3ZVQ6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

163003:CL1 RS06230
gene id: 163003:CL1_RS06230
uniprot id: I3ZUM1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

163003:CL1 RS07855
gene id: 163003:CL1_RS07855
uniprot id: I3ZVH9
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS00735
gene id: 163003:CL1_RS00735
uniprot id: I3ZRM7
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

163003:CL1 RS02820
gene id: 163003:CL1_RS02820
uniprot id: I3ZSS0
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

163003:CL1 RS07850
gene id: 163003:CL1_RS07850
uniprot id: I3ZVH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

163003:CL1 RS01720
gene id: 163003:CL1_RS01720
uniprot id: I3ZS66
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

163003:CL1 RS08730
gene id: 163003:CL1_RS08730
uniprot id: I3ZW02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

163003:CL1 RS06510
gene id: 163003:CL1_RS06510
uniprot id: I3ZUS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

163003:CL1 RS07600
gene id: 163003:CL1_RS07600
uniprot id: I3ZVC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

163003:CL1 RS01030
gene id: 163003:CL1_RS01030
uniprot id: I3ZRT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

163003:CL1 RS03825
gene id: 163003:CL1_RS03825
uniprot id: I3ZTA6
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

163003:CL1 RS05085
gene id: 163003:CL1_RS05085
uniprot id: I3ZTZ9
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS01945
gene id: 163003:CL1_RS01945
uniprot id: I3ZSB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

163003:CL1 RS02420
gene id: 163003:CL1_RS02420
uniprot id: I3ZSJ3
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

163003:CL1 RS03325
gene id: 163003:CL1_RS03325
uniprot id: I3ZT11
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

163003:CL1 RS02815
gene id: 163003:CL1_RS02815
uniprot id: I3ZSR9
names: Similarity
messages: Belongs to the P(II) protein family.

163003:CL1 RS00550
gene id: 163003:CL1_RS00550
uniprot id: I3ZRJ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

163003:CL1 RS04135
gene id: 163003:CL1_RS04135
uniprot id: I3ZTG4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

163003:CL1 RS03980
gene id: 163003:CL1_RS03980
uniprot id: I3ZTD3
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

163003:CL1 RS07425
gene id: 163003:CL1_RS07425
uniprot id: I3ZV95
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

163003:CL1 RS01955
gene id: 163003:CL1_RS01955
uniprot id: I3ZSB2
names: Similarity
messages: Belongs to the glutaredoxin family.

163003:CL1 RS02875
gene id: 163003:CL1_RS02875
uniprot id: I3ZST1
names: Similarity
messages: Belongs to the peptidase M24B family.

163003:CL1 RS00210
gene id: 163003:CL1_RS00210
uniprot id: I3ZRC4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the N-terminal section; belongs to the DHBP synthase family.

163003:CL1 RS03995
gene id: 163003:CL1_RS03995
uniprot id: I3ZTD6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

163003:CL1 RS07725
gene id: 163003:CL1_RS07725
uniprot id: I3ZVF3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

163003:CL1 RS03805
gene id: 163003:CL1_RS03805
uniprot id: I3ZTA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

163003:CL1 RS09405
gene id: 163003:CL1_RS09405
uniprot id: I3ZWD4
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

163003:CL1 RS01150
gene id: 163003:CL1_RS01150
uniprot id: I3ZRV6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

163003:CL1 RS06715
gene id: 163003:CL1_RS06715
uniprot id: I3ZUW1
names: Similarity
messages: Belongs to the UPF0047 family.

163003:CL1 RS01820
gene id: 163003:CL1_RS01820
uniprot id: I3ZS85
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS04965
gene id: 163003:CL1_RS04965
uniprot id: I3ZTX6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

163003:CL1 RS01685
gene id: 163003:CL1_RS01685
uniprot id: I3ZS59
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.
messages: Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif).
messages: DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS09880
gene id: 163003:CL1_RS09880
uniprot id: I3ZWM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

163003:CL1 RS03485
gene id: 163003:CL1_RS03485
uniprot id: I3ZT42
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

163003:CL1 RS04865
gene id: 163003:CL1_RS04865
uniprot id: I3ZTV7
names: Function
messages: Part of a potassium transport system.

163003:CL1 RS02530
gene id: 163003:CL1_RS02530
uniprot id: I3ZSL4
names: Similarity
messages: Belongs to the HypE family.

163003:CL1 RS04585
gene id: 163003:CL1_RS04585
uniprot id: I3ZTQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

163003:CL1 RS00980
gene id: 163003:CL1_RS00980
uniprot id: I3ZRS2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

163003:CL1 RS04870
gene id: 163003:CL1_RS04870
uniprot id: I3ZTV8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

163003:CL1 RS01445
gene id: 163003:CL1_RS01445
uniprot id: I3ZS14
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

163003:CL1 RS05590
gene id: 163003:CL1_RS05590
uniprot id: I3ZU99
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

163003:CL1 RS02030
gene id: 163003:CL1_RS02030
uniprot id: I3ZSC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

163003:CL1 RS08520
gene id: 163003:CL1_RS08520
uniprot id: I3ZVW1
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS05135
gene id: 163003:CL1_RS05135
uniprot id: I3ZU09
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS02305
gene id: 163003:CL1_RS02305
uniprot id: I3ZSH3
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS03260
gene id: 163003:CL1_RS03260
uniprot id: I3ZSZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

163003:CL1 RS01485
gene id: 163003:CL1_RS01485
uniprot id: I3ZS21
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

163003:CL1 RS03125
gene id: 163003:CL1_RS03125
uniprot id: I3ZSX2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

163003:CL1 RS06655
gene id: 163003:CL1_RS06655
uniprot id: I3ZUU9
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

163003:CL1 RS09690
gene id: 163003:CL1_RS09690
uniprot id: I3ZWJ1
names: Similarity
messages: Belongs to the peptidase U62 family.

163003:CL1 RS03470
gene id: 163003:CL1_RS03470
uniprot id: I3ZT39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

163003:CL1 RS03180
gene id: 163003:CL1_RS03180
uniprot id: I3ZSY3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

163003:CL1 RS09020
gene id: 163003:CL1_RS09020
uniprot id: I3ZW55
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

163003:CL1 RS06570
gene id: 163003:CL1_RS06570
uniprot id: I3ZUT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

163003:CL1 RS00635
gene id: 163003:CL1_RS00635
uniprot id: I3ZRK7
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

163003:CL1 RS05895
gene id: 163003:CL1_RS05895
uniprot id: I3ZUF8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

163003:CL1 RS02055
gene id: 163003:CL1_RS02055
uniprot id: I3ZSD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

163003:CL1 RS09265
gene id: 163003:CL1_RS09265
uniprot id: I3ZWA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

163003:CL1 RS07390
gene id: 163003:CL1_RS07390
uniprot id: I3ZV88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

163003:CL1 RS04085
gene id: 163003:CL1_RS04085
uniprot id: I3ZTF3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

163003:CL1 RS03220
gene id: 163003:CL1_RS03220
uniprot id: I3ZSZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

163003:CL1 RS02580
gene id: 163003:CL1_RS02580
uniprot id: I3ZSM4
names: Similarity
messages: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.

163003:CL1 RS03560
gene id: 163003:CL1_RS03560
uniprot id: I3ZT57
names: Similarity
messages: Belongs to the thioesterase PaaI family.

163003:CL1 RS00110
gene id: 163003:CL1_RS00110
uniprot id: I3ZRA4
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS00925
gene id: 163003:CL1_RS00925
uniprot id: I3ZRR1
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

163003:CL1 RS00425
gene id: 163003:CL1_RS00425
uniprot id: I3ZRG6
names: Similarity
messages: Belongs to the CinA family.

163003:CL1 RS03095
gene id: 163003:CL1_RS03095
uniprot id: I3ZSW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

163003:CL1 RS05475
gene id: 163003:CL1_RS05475
uniprot id: I3ZU77
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

163003:CL1 RS00055
gene id: 163003:CL1_RS00055
uniprot id: I3ZR93
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

163003:CL1 RS04735
gene id: 163003:CL1_RS04735
uniprot id: I3ZTT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

163003:CL1 RS09950
gene id: 163003:CL1_RS09950
uniprot id: I3ZWP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

163003:CL1 RS05485
gene id: 163003:CL1_RS05485
uniprot id: I3ZU79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

163003:CL1 RS08715
gene id: 163003:CL1_RS08715
uniprot id: I3ZVZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

163003:CL1 RS05880
gene id: 163003:CL1_RS05880
uniprot id: I3ZUF5
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS03330
gene id: 163003:CL1_RS03330
uniprot id: I3ZT12
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.

163003:CL1 RS08800
gene id: 163003:CL1_RS08800
uniprot id: I3ZW16
names: Similarity
messages: Belongs to the peptidase S9C family.

163003:CL1 RS09190
gene id: 163003:CL1_RS09190
uniprot id: I3ZW89
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

163003:CL1 RS04615
gene id: 163003:CL1_RS04615
uniprot id: I3ZTQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

163003:CL1 RS04625
gene id: 163003:CL1_RS04625
uniprot id: I3ZTR0
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS02020
gene id: 163003:CL1_RS02020
uniprot id: I3ZSC3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

163003:CL1 RS08565
gene id: 163003:CL1_RS08565
uniprot id: I3ZVW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

163003:CL1 RS03195
gene id: 163003:CL1_RS03195
uniprot id: I3ZSY6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

163003:CL1 RS03160
gene id: 163003:CL1_RS03160
uniprot id: I3ZSX9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

163003:CL1 RS01800
gene id: 163003:CL1_RS01800
uniprot id: I3ZS81
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

163003:CL1 RS04830
gene id: 163003:CL1_RS04830
uniprot id: I3ZTV0
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

163003:CL1 RS02915
gene id: 163003:CL1_RS02915
uniprot id: I3ZST8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

163003:CL1 RS00250
gene id: 163003:CL1_RS00250
uniprot id: I3ZRD2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

163003:CL1 RS04055
gene id: 163003:CL1_RS04055
uniprot id: I3ZTE7
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

163003:CL1 RS08710
gene id: 163003:CL1_RS08710
uniprot id: I3ZVZ8
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS06410
gene id: 163003:CL1_RS06410
uniprot id: I3ZUQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

163003:CL1 RS03150
gene id: 163003:CL1_RS03150
uniprot id: I3ZSX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

163003:CL1 RS09080
gene id: 163003:CL1_RS09080
uniprot id: I3ZW67
names: Similarity
messages: Belongs to the HerA family.

163003:CL1 RS04105
gene id: 163003:CL1_RS04105
uniprot id: I3ZTF7
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

163003:CL1 RS01135
gene id: 163003:CL1_RS01135
uniprot id: I3ZRV3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS04700
gene id: 163003:CL1_RS04700
uniprot id: I3ZTS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

163003:CL1 RS09315
gene id: 163003:CL1_RS09315
uniprot id: I3ZWB6
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS02050
gene id: 163003:CL1_RS02050
uniprot id: I3ZSC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

163003:CL1 RS09025
gene id: 163003:CL1_RS09025
uniprot id: I3ZW56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

163003:CL1 RS01915
gene id: 163003:CL1_RS01915
uniprot id: I3ZSA4
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

163003:CL1 RS02500
gene id: 163003:CL1_RS02500
uniprot id: I3ZSK8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

163003:CL1 RS10380
gene id: 163003:CL1_RS10380
uniprot id: I3ZWX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

163003:CL1 RS05550
gene id: 163003:CL1_RS05550
uniprot id: I3ZU92
names: Similarity
messages: Belongs to the UPF0310 family.

163003:CL1 RS01535
gene id: 163003:CL1_RS01535
uniprot id: I3ZS31
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS07895
gene id: 163003:CL1_RS07895
uniprot id: I3ZVI7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

163003:CL1 RS07605
gene id: 163003:CL1_RS07605
uniprot id: I3ZVC9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

163003:CL1 RS09655
gene id: 163003:CL1_RS09655
uniprot id: I3ZWI4
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

163003:CL1 RS03745
gene id: 163003:CL1_RS03745
uniprot id: I3ZT90
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

163003:CL1 RS09075
gene id: 163003:CL1_RS09075
uniprot id: I3ZW66
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

163003:CL1 RS08330
gene id: 163003:CL1_RS08330
uniprot id: I3ZVS4
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

163003:CL1 RS03135
gene id: 163003:CL1_RS03135
uniprot id: I3ZSX4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

163003:CL1 RS06020
gene id: 163003:CL1_RS06020
uniprot id: I3ZUI1
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

163003:CL1 RS03810
gene id: 163003:CL1_RS03810
uniprot id: I3ZTA3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

163003:CL1 RS01350
gene id: 163003:CL1_RS01350
uniprot id: I3ZRZ6
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS02935
gene id: 163003:CL1_RS02935
uniprot id: I3ZSU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

163003:CL1 RS03960
gene id: 163003:CL1_RS03960
uniprot id: I3ZTC9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

163003:CL1 RS02035
gene id: 163003:CL1_RS02035
uniprot id: I3ZSC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

163003:CL1 RS07345
gene id: 163003:CL1_RS07345
uniprot id: I3ZV80
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

163003:CL1 RS01155
gene id: 163003:CL1_RS01155
uniprot id: I3ZRV7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

163003:CL1 RS09145
gene id: 163003:CL1_RS09145
uniprot id: I3ZW80
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

163003:CL1 RS07050
gene id: 163003:CL1_RS07050
uniprot id: I3ZV25
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

163003:CL1 RS04015
gene id: 163003:CL1_RS04015
uniprot id: I3ZTE0
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS03450
gene id: 163003:CL1_RS03450
uniprot id: I3ZT35
names: Similarity
messages: Belongs to the ZPR1 family.

163003:CL1 RS06355
gene id: 163003:CL1_RS06355
uniprot id: I3ZUP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

163003:CL1 RS03650
gene id: 163003:CL1_RS03650
uniprot id: I3ZT74
names: Similarity
messages: Belongs to the UPF0045 family.

163003:CL1 RS06560
gene id: 163003:CL1_RS06560
uniprot id: I3ZUT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

163003:CL1 RS09335
gene id: 163003:CL1_RS09335
uniprot id: I3ZWC0
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS00005
gene id: 163003:CL1_RS00005
uniprot id: I3ZR83
names: Cofactor
messages: Binds 1 zinc ion per subunit.

163003:CL1 RS04185
gene id: 163003:CL1_RS04185
uniprot id: I3ZTH4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

163003:CL1 RS05000
gene id: 163003:CL1_RS05000
uniprot id: I3ZTY3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

163003:CL1 RS09625
gene id: 163003:CL1_RS09625
uniprot id: I3ZWH8
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

163003:CL1 RS02635
gene id: 163003:CL1_RS02635
uniprot id: I3ZSN5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

163003:CL1 RS07275
gene id: 163003:CL1_RS07275
uniprot id: I3ZV66
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

163003:CL1 RS08220
gene id: 163003:CL1_RS08220
uniprot id: I3ZVQ3
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

163003:CL1 RS01805
gene id: 163003:CL1_RS01805
uniprot id: I3ZS82
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

163003:CL1 RS06160
gene id: 163003:CL1_RS06160
uniprot id: I3ZUK7
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS02275
gene id: 163003:CL1_RS02275
uniprot id: I3ZSG8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

163003:CL1 RS05655
gene id: 163003:CL1_RS05655
uniprot id: I3ZUB1
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

163003:CL1 RS02765
gene id: 163003:CL1_RS02765
uniprot id: I3ZSQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

163003:CL1 RS09050
gene id: 163003:CL1_RS09050
uniprot id: I3ZW61
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.
messages: Cytoplasm
messages: Homodimer.

163003:CL1 RS05875
gene id: 163003:CL1_RS05875
uniprot id: I3ZUF4
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS10080
gene id: 163003:CL1_RS10080
uniprot id: I3ZWR8
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

163003:CL1 RS08550
gene id: 163003:CL1_RS08550
uniprot id: I3ZVW6
names: Similarity
messages: Belongs to the SfsA family.

163003:CL1 RS04695
gene id: 163003:CL1_RS04695
uniprot id: I3ZTS4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

163003:CL1 RS01320
gene id: 163003:CL1_RS01320
uniprot id: I3ZRZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

163003:CL1 RS09170
gene id: 163003:CL1_RS09170
uniprot id: I3ZW85
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

163003:CL1 RS00455
gene id: 163003:CL1_RS00455
uniprot id: I3ZRH2
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

163003:CL1 RS06645
gene id: 163003:CL1_RS06645
uniprot id: I3ZUU7
names: Similarity
messages: Belongs to the BtpA family.

163003:CL1 RS10210
gene id: 163003:CL1_RS10210
uniprot id: I3ZWU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

163003:CL1 RS05785
gene id: 163003:CL1_RS05785
uniprot id: I3ZUD6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

163003:CL1 RS04100
gene id: 163003:CL1_RS04100
uniprot id: I3ZTF6
names: Similarity
messages: Belongs to the GARS family.

163003:CL1 RS03265
gene id: 163003:CL1_RS03265
uniprot id: I3ZSZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

163003:CL1 RS07420
gene id: 163003:CL1_RS07420
uniprot id: I3ZV94
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS02465
gene id: 163003:CL1_RS02465
uniprot id: I3ZSK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

163003:CL1 RS02730
gene id: 163003:CL1_RS02730
uniprot id: I3ZSQ4
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

163003:CL1 RS06470
gene id: 163003:CL1_RS06470
uniprot id: I3ZUR5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

163003:CL1 RS06535
gene id: 163003:CL1_RS06535
uniprot id: I3ZUS7
names: Similarity
messages: Belongs to the class-I fumarase family.

163003:CL1 RS09965
gene id: 163003:CL1_RS09965
uniprot id: I3ZWP4
names: Similarity
messages: Belongs to the AOR/FOR family.

163003:CL1 RS02805
gene id: 163003:CL1_RS02805
uniprot id: I3ZSR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

163003:CL1 RS00960
gene id: 163003:CL1_RS00960
uniprot id: I3ZRR8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

163003:CL1 RS07960
gene id: 163003:CL1_RS07960
uniprot id: I3ZVK0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS08080
gene id: 163003:CL1_RS08080
uniprot id: I3ZVM3
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

163003:CL1 RS00040
gene id: 163003:CL1_RS00040
uniprot id: I3ZR90
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

163003:CL1 RS10240
gene id: 163003:CL1_RS10240
uniprot id: I3ZWV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

163003:CL1 RS03385
gene id: 163003:CL1_RS03385
uniprot id: I3ZT23
names: Subcellular Location Annotation
messages: Nucleus

163003:CL1 RS08860
gene id: 163003:CL1_RS08860
uniprot id: I3ZW27
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS05290
gene id: 163003:CL1_RS05290
uniprot id: I3ZU40
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS01490
gene id: 163003:CL1_RS01490
uniprot id: I3ZS22
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS00010
gene id: 163003:CL1_RS00010
uniprot id: I3ZR84
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

163003:CL1 RS05885
gene id: 163003:CL1_RS05885
uniprot id: I3ZUF6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

163003:CL1 RS01325
gene id: 163003:CL1_RS01325
uniprot id: I3ZRZ1
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

163003:CL1 RS06370
gene id: 163003:CL1_RS06370
uniprot id: I3ZUP5
names: Similarity
messages: Belongs to the CutA family.

163003:CL1 RS02485
gene id: 163003:CL1_RS02485
uniprot id: I3ZSK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

163003:CL1 RS04605
gene id: 163003:CL1_RS04605
uniprot id: I3ZTQ6
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

163003:CL1 RS01495
gene id: 163003:CL1_RS01495
uniprot id: I3ZS23
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

163003:CL1 RS03895
gene id: 163003:CL1_RS03895
uniprot id: I3ZTB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

163003:CL1 RS01425
gene id: 163003:CL1_RS01425
uniprot id: I3ZS11
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

163003:CL1 RS02690
gene id: 163003:CL1_RS02690
uniprot id: I3ZSP6
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

163003:CL1 RS06420
gene id: 163003:CL1_RS06420
uniprot id: I3ZUQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

163003:CL1 RS00205
gene id: 163003:CL1_RS00205
uniprot id: I3ZRC3
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

163003:CL1 RS07545
gene id: 163003:CL1_RS07545
uniprot id: I3ZVB9
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS08150
gene id: 163003:CL1_RS08150
uniprot id: I3ZVN8
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

163003:CL1 RS07645
gene id: 163003:CL1_RS07645
uniprot id: I3ZVD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

163003:CL1 RS03045
gene id: 163003:CL1_RS03045
uniprot id: I3ZSW0
names: Similarity
messages: Belongs to the enolase family.

163003:CL1 RS07550
gene id: 163003:CL1_RS07550
uniprot id: I3ZVC0
names: Similarity
messages: Belongs to the UPF0201 family.

163003:CL1 RS02085
gene id: 163003:CL1_RS02085
uniprot id: I3ZSD5
names: Similarity
messages: Belongs to the UPF0292 family.

163003:CL1 RS08770
gene id: 163003:CL1_RS08770
uniprot id: I3ZW10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

163003:CL1 RS10060
gene id: 163003:CL1_RS10060
uniprot id: I3ZWR4
names: Similarity
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.

163003:CL1 RS06975
gene id: 163003:CL1_RS06975
uniprot id: I3ZV11
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

163003:CL1 RS10245
gene id: 163003:CL1_RS10245
uniprot id: I3ZWV1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

163003:CL1 RS09410
gene id: 163003:CL1_RS09410
uniprot id: I3ZWD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

163003:CL1 RS04635
gene id: 163003:CL1_RS04635
uniprot id: I3ZTR2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

163003:CL1 RS07810
gene id: 163003:CL1_RS07810
uniprot id: I3ZVH0
names: Similarity
messages: Belongs to the UPF0047 family.

163003:CL1 RS02870
gene id: 163003:CL1_RS02870
uniprot id: I3ZST0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

163003:CL1 RS02480
gene id: 163003:CL1_RS02480
uniprot id: I3ZSK5
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

163003:CL1 RS02400
gene id: 163003:CL1_RS02400
uniprot id: I3ZSJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

163003:CL1 RS06930
gene id: 163003:CL1_RS06930
uniprot id: I3ZV02
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

163003:CL1 RS06520
gene id: 163003:CL1_RS06520
uniprot id: I3ZUS4
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

163003:CL1 RS09710
gene id: 163003:CL1_RS09710
uniprot id: I3ZWJ4
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

163003:CL1 RS06940
gene id: 163003:CL1_RS06940
uniprot id: I3ZV04
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

163003:CL1 RS10100
gene id: 163003:CL1_RS10100
uniprot id: I3ZWS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

163003:CL1 RS08415
gene id: 163003:CL1_RS08415
uniprot id: I3ZVT9
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

163003:CL1 RS02825
gene id: 163003:CL1_RS02825
uniprot id: I3ZSS1
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

163003:CL1 RS04210
gene id: 163003:CL1_RS04210
uniprot id: I3ZTH9
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

163003:CL1 RS01290
gene id: 163003:CL1_RS01290
uniprot id: I3ZRY4
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS09645
gene id: 163003:CL1_RS09645
uniprot id: I3ZWI2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-64 and Arg-67) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

163003:CL1 RS10095
gene id: 163003:CL1_RS10095
uniprot id: I3ZWS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

163003:CL1 RS03130
gene id: 163003:CL1_RS03130
uniprot id: I3ZSX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

163003:CL1 RS03955
gene id: 163003:CL1_RS03955
uniprot id: I3ZTC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

163003:CL1 RS00370
gene id: 163003:CL1_RS00370
uniprot id: I3ZRF5
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS05095
gene id: 163003:CL1_RS05095
uniprot id: I3ZU01
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

163003:CL1 RS06385
gene id: 163003:CL1_RS06385
uniprot id: I3ZUP8
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

163003:CL1 RS02945
gene id: 163003:CL1_RS02945
uniprot id: I3ZSU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
messages: Cytoplasm

163003:CL1 RS02800
gene id: 163003:CL1_RS02800
uniprot id: I3ZSR6
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

163003:CL1 RS00320
gene id: 163003:CL1_RS00320
uniprot id: I3ZRE5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

163003:CL1 RS03215
gene id: 163003:CL1_RS03215
uniprot id: I3ZSZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

163003:CL1 RS03060
gene id: 163003:CL1_RS03060
uniprot id: I3ZSW2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

163003:CL1 RS10220
gene id: 163003:CL1_RS10220
uniprot id: I3ZWU6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

163003:CL1 RS10485
gene id: 163003:CL1_RS10485
uniprot id: I3ZWZ8
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS05810
gene id: 163003:CL1_RS05810
uniprot id: I3ZUE1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

163003:CL1 RS07510
gene id: 163003:CL1_RS07510
uniprot id: I3ZVB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

163003:CL1 RS05360
gene id: 163003:CL1_RS05360
uniprot id: I3ZU54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

163003:CL1 RS00020
gene id: 163003:CL1_RS00020
uniprot id: I3ZR86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

163003:CL1 RS06035
gene id: 163003:CL1_RS06035
uniprot id: I3ZUI4
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS06945
gene id: 163003:CL1_RS06945
uniprot id: I3ZV05
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

163003:CL1 RS09955
gene id: 163003:CL1_RS09955
uniprot id: I3ZWP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

163003:CL1 RS03075
gene id: 163003:CL1_RS03075
uniprot id: I3ZSW5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

163003:CL1 RS00365
gene id: 163003:CL1_RS00365
uniprot id: I3ZRF4
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS03065
gene id: 163003:CL1_RS03065
uniprot id: I3ZSW3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

163003:CL1 RS04755
gene id: 163003:CL1_RS04755
uniprot id: I3ZTT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

163003:CL1 RS06045
gene id: 163003:CL1_RS06045
uniprot id: I3ZUI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

163003:CL1 RS08195
gene id: 163003:CL1_RS08195
uniprot id: I3ZVP8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

163003:CL1 RS10160
gene id: 163003:CL1_RS10160
uniprot id: I3ZWT3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

163003:CL1 RS09725
gene id: 163003:CL1_RS09725
uniprot id: I3ZWJ7
names: Similarity
messages: Belongs to the UPF0166 family.

163003:CL1 RS10055
gene id: 163003:CL1_RS10055
uniprot id: I3ZWR3
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.

163003:CL1 RS05125
gene id: 163003:CL1_RS05125
uniprot id: I3ZU07
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

163003:CL1 RS06835
gene id: 163003:CL1_RS06835
uniprot id: I3ZUY5
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

163003:CL1 RS03145
gene id: 163003:CL1_RS03145
uniprot id: I3ZSX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

163003:CL1 RS04790
gene id: 163003:CL1_RS04790
uniprot id: I3ZTU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

163003:CL1 RS02965
gene id: 163003:CL1_RS02965
uniprot id: I3ZSU6
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

163003:CL1 RS00860
gene id: 163003:CL1_RS00860
uniprot id: I3ZRQ1
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS05075
gene id: 163003:CL1_RS05075
uniprot id: I3ZTZ7
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

163003:CL1 RS09415
gene id: 163003:CL1_RS09415
uniprot id: I3ZWD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

163003:CL1 RS07535
gene id: 163003:CL1_RS07535
uniprot id: I3ZVB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

163003:CL1 RS06140
gene id: 163003:CL1_RS06140
uniprot id: I3ZUK4
names: Subunit
messages: Homotetramer.

163003:CL1 RS00580
gene id: 163003:CL1_RS00580
uniprot id: I3ZRJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

163003:CL1 RS03245
gene id: 163003:CL1_RS03245
uniprot id: I3ZSZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

163003:CL1 RS01005
gene id: 163003:CL1_RS01005
uniprot id: I3ZRS7
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

163003:CL1 RS02505
gene id: 163003:CL1_RS02505
uniprot id: I3ZSK9
names: Similarity
messages: Belongs to the HupF/HypC family.

163003:CL1 RS04370
gene id: 163003:CL1_RS04370
uniprot id: I3ZTK9
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS10415
gene id: 163003:CL1_RS10415
uniprot id: I3ZWY5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

163003:CL1 RS03740
gene id: 163003:CL1_RS03740
uniprot id: I3ZT89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

163003:CL1 RS04760
gene id: 163003:CL1_RS04760
uniprot id: I3ZTT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

163003:CL1 RS09495
gene id: 163003:CL1_RS09495
uniprot id: I3ZWF2
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

163003:CL1 RS04475
gene id: 163003:CL1_RS04475
uniprot id: I3ZTN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

163003:CL1 RS08200
gene id: 163003:CL1_RS08200
uniprot id: I3ZVP9
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS06970
gene id: 163003:CL1_RS06970
uniprot id: I3ZV10
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

163003:CL1 RS04785
gene id: 163003:CL1_RS04785
uniprot id: I3ZTU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

163003:CL1 RS10175
gene id: 163003:CL1_RS10175
uniprot id: I3ZWT6
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

163003:CL1 RS01750
gene id: 163003:CL1_RS01750
uniprot id: I3ZS72
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

163003:CL1 RS06790
gene id: 163003:CL1_RS06790
uniprot id: I3ZUX6
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

163003:CL1 RS05630
gene id: 163003:CL1_RS05630
uniprot id: I3ZUA6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

163003:CL1 RS09865
gene id: 163003:CL1_RS09865
uniprot id: I3ZWM5
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

163003:CL1 RS05045
gene id: 163003:CL1_RS05045
uniprot id: I3ZTZ1
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

163003:CL1 RS07340
gene id: 163003:CL1_RS07340
uniprot id: I3ZV79
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

163003:CL1 RS04945
gene id: 163003:CL1_RS04945
uniprot id: I3ZTX2
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

163003:CL1 RS01250
gene id: 163003:CL1_RS01250
uniprot id: I3ZRX6
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

163003:CL1 RS07435
gene id: 163003:CL1_RS07435
uniprot id: I3ZV97
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

163003:CL1 RS01990
gene id: 163003:CL1_RS01990
uniprot id: I3ZSB7
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

163003:CL1 RS10465
gene id: 163003:CL1_RS10465
uniprot id: I3ZWZ4
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

163003:CL1 RS01550
gene id: 163003:CL1_RS01550
uniprot id: I3ZS34
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS09140
gene id: 163003:CL1_RS09140
uniprot id: I3ZW79
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

163003:CL1 RS01770
gene id: 163003:CL1_RS01770
uniprot id: I3ZS77
names: Similarity
messages: Belongs to the UPF0212 family.

163003:CL1 RS04610
gene id: 163003:CL1_RS04610
uniprot id: I3ZTQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

163003:CL1 RS04810
gene id: 163003:CL1_RS04810
uniprot id: I3ZTU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

163003:CL1 RS05925
gene id: 163003:CL1_RS05925
uniprot id: I3ZUG4
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS07540
gene id: 163003:CL1_RS07540
uniprot id: I3ZVB8
names: Similarity
messages: Belongs to the UPF0200 family.

163003:CL1 RS08190
gene id: 163003:CL1_RS08190
uniprot id: I3ZVP7
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

163003:CL1 RS00280
gene id: 163003:CL1_RS00280
uniprot id: I3ZRD7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

163003:CL1 RS06250
gene id: 163003:CL1_RS06250
uniprot id: I3ZUM4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

163003:CL1 RS03625
gene id: 163003:CL1_RS03625
uniprot id: I3ZT69
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

163003:CL1 RS01310
gene id: 163003:CL1_RS01310
uniprot id: I3ZRY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

163003:CL1 RS00650
gene id: 163003:CL1_RS00650
uniprot id: I3ZRL0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS01715
gene id: 163003:CL1_RS01715
uniprot id: I3ZS65
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS06040
gene id: 163003:CL1_RS06040
uniprot id: I3ZUI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

163003:CL1 RS09790
gene id: 163003:CL1_RS09790
uniprot id: I3ZWL0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

163003:CL1 RS00985
gene id: 163003:CL1_RS00985
uniprot id: I3ZRS3
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS10260
gene id: 163003:CL1_RS10260
uniprot id: I3ZWV4
names: Similarity
messages: Belongs to the HepT RNase toxin family.

163003:CL1 RS00605
gene id: 163003:CL1_RS00605
uniprot id: I3ZRK2
names: Similarity
messages: Belongs to the NodU/CmcH family.

163003:CL1 RS01570
gene id: 163003:CL1_RS01570
uniprot id: I3ZS38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

163003:CL1 RS03380
gene id: 163003:CL1_RS03380
uniprot id: I3ZT22
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

163003:CL1 RS08120
gene id: 163003:CL1_RS08120
uniprot id: I3ZVN2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

163003:CL1 RS00965
gene id: 163003:CL1_RS00965
uniprot id: I3ZRR9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

163003:CL1 RS06965
gene id: 163003:CL1_RS06965
uniprot id: I3ZV09
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

163003:CL1 RS09860
gene id: 163003:CL1_RS09860
uniprot id: I3ZWM4
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

163003:CL1 RS03480
gene id: 163003:CL1_RS03480
uniprot id: I3ZT41
names: Similarity
messages: Belongs to the SDO1/SBDS family.

163003:CL1 RS01925
gene id: 163003:CL1_RS01925
uniprot id: I3ZSA6
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

163003:CL1 RS09350
gene id: 163003:CL1_RS09350
uniprot id: I3ZWC3
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

163003:CL1 RS07825
gene id: 163003:CL1_RS07825
uniprot id: I3ZVH3
names: Subunit
messages: Homodimer.

163003:CL1 RS07845
gene id: 163003:CL1_RS07845
uniprot id: I3ZVH7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

163003:CL1 RS04895
gene id: 163003:CL1_RS04895
uniprot id: I3ZTW3
names: Similarity
messages: Belongs to the UPF0273 family.

163003:CL1 RS05905
gene id: 163003:CL1_RS05905
uniprot id: I3ZUG0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

163003:CL1 RS01810
gene id: 163003:CL1_RS01810
uniprot id: I3ZS83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

163003:CL1 RS03635
gene id: 163003:CL1_RS03635
uniprot id: I3ZT71
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

163003:CL1 RS05235
gene id: 163003:CL1_RS05235
uniprot id: I3ZU29
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

163003:CL1 RS04075
gene id: 163003:CL1_RS04075
uniprot id: I3ZTF1
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

163003:CL1 RS05220
gene id: 163003:CL1_RS05220
uniprot id: I3ZU26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

163003:CL1 RS02940
gene id: 163003:CL1_RS02940
uniprot id: I3ZSU3
names: Similarity
messages: Belongs to the MEMO1 family.

163003:CL1 RS07910
gene id: 163003:CL1_RS07910
uniprot id: I3ZVJ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

163003:CL1 RS04840
gene id: 163003:CL1_RS04840
uniprot id: I3ZTV2
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

163003:CL1 RS02045
gene id: 163003:CL1_RS02045
uniprot id: I3ZSC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

163003:CL1 RS04490
gene id: 163003:CL1_RS04490
uniprot id: I3ZTN3
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

163003:CL1 RS01875
gene id: 163003:CL1_RS01875
uniprot id: I3ZS96
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

163003:CL1 RS03200
gene id: 163003:CL1_RS03200
uniprot id: I3ZSY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

163003:CL1 RS00495
gene id: 163003:CL1_RS00495
uniprot id: I3ZRI0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

163003:CL1 RS03840
gene id: 163003:CL1_RS03840
uniprot id: I3ZTA9
names: Similarity
messages: Belongs to the UPF0145 family.

163003:CL1 RS07635
gene id: 163003:CL1_RS07635
uniprot id: I3ZVD5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS04505
gene id: 163003:CL1_RS04505
uniprot id: I3ZTN6
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

163003:CL1 RS01420
gene id: 163003:CL1_RS01420
uniprot id: I3ZS10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

163003:CL1 RS00865
gene id: 163003:CL1_RS00865
uniprot id: I3ZRQ2
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS08865
gene id: 163003:CL1_RS08865
uniprot id: I3ZW28
names: Similarity
messages: Belongs to the band 7/mec-2 family.

163003:CL1 RS09875
gene id: 163003:CL1_RS09875
uniprot id: I3ZWM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

163003:CL1 RS08630
gene id: 163003:CL1_RS08630
uniprot id: I3ZVY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

163003:CL1 RS04850
gene id: 163003:CL1_RS04850
uniprot id: I3ZTV4
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS03395
gene id: 163003:CL1_RS03395
uniprot id: I3ZT25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

163003:CL1 RS05130
gene id: 163003:CL1_RS05130
uniprot id: I3ZU08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

163003:CL1 RS01265
gene id: 163003:CL1_RS01265
uniprot id: I3ZRX9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

163003:CL1 RS04155
gene id: 163003:CL1_RS04155
uniprot id: I3ZTG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

163003:CL1 RS02365
gene id: 163003:CL1_RS02365
uniprot id: I3ZSI3
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

163003:CL1 RS01975
gene id: 163003:CL1_RS01975
uniprot id: I3ZSB6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

163003:CL1 RS02105
gene id: 163003:CL1_RS02105
uniprot id: I3ZSD9
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

163003:CL1 RS02285
gene id: 163003:CL1_RS02285
uniprot id: I3ZSH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

163003:CL1 RS06705
gene id: 163003:CL1_RS06705
uniprot id: I3ZUV9
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

163003:CL1 RS07965
gene id: 163003:CL1_RS07965
uniprot id: I3ZVK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

163003:CL1 RS02075
gene id: 163003:CL1_RS02075
uniprot id: I3ZSD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

163003:CL1 RS03415
gene id: 163003:CL1_RS03415
uniprot id: I3ZT29
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

163003:CL1 RS00355
gene id: 163003:CL1_RS00355
uniprot id: I3ZRF2
names: Function
names: PTM
names: Similarity
messages: Belongs to the HepT RNase toxin family.
messages: Modified by cognate antitoxin MntA; probably at least 2 successive AMPylation events occur on Tyr-82.
messages: Toxic component of a type VII toxin-antitoxin (TA) system. Overexpression in E.coli inhibits cell growth. Neutralized by cognate antitoxin MntA (PubMed:33045733). Neutralization is probably due to AMPylation by MntA (Probable). Probably an RNAase (By similarity).

163003:CL1 RS06215
gene id: 163003:CL1_RS06215
uniprot id: I3ZUL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

163003:CL1 RS03155
gene id: 163003:CL1_RS03155
uniprot id: I3ZSX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

163003:CL1 RS09360
gene id: 163003:CL1_RS09360
uniprot id: I3ZWC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

163003:CL1 RS07285
gene id: 163003:CL1_RS07285
uniprot id: I3ZV68
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

163003:CL1 RS07355
gene id: 163003:CL1_RS07355
uniprot id: I3ZV82
names: Similarity
messages: Belongs to the UPF0173 family.

163003:CL1 RS06395
gene id: 163003:CL1_RS06395
uniprot id: I3ZUQ0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

163003:CL1 RS09070
gene id: 163003:CL1_RS09070
uniprot id: I3ZW65
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

163003:CL1 RS08260
gene id: 163003:CL1_RS08260
uniprot id: I3ZVR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

163003:CL1 RS03695
gene id: 163003:CL1_RS03695
uniprot id: I3ZT83
names: Similarity
messages: Belongs to the DtxR/MntR family.

163003:CL1 RS04550
gene id: 163003:CL1_RS04550
uniprot id: I3ZTP5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

163003:CL1 RS01860
gene id: 163003:CL1_RS01860
uniprot id: I3ZS93
names: Similarity
messages: Belongs to the arginase family.

163003:CL1 RS03770
gene id: 163003:CL1_RS03770
uniprot id: I3ZT95
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

163003:CL1 RS03465
gene id: 163003:CL1_RS03465
uniprot id: I3ZT38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

163003:CL1 RS04950
gene id: 163003:CL1_RS04950
uniprot id: I3ZTX3
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

163003:CL1 RS09385
gene id: 163003:CL1_RS09385
uniprot id: I3ZWD0
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.

163003:CL1 RS00080
gene id: 163003:CL1_RS00080
uniprot id: I3ZR98
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

163003:CL1 RS07720
gene id: 163003:CL1_RS07720
uniprot id: I3ZVF2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

163003:CL1 RS03365
gene id: 163003:CL1_RS03365
uniprot id: I3ZT19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

163003:CL1 RS07620
gene id: 163003:CL1_RS07620
uniprot id: I3ZVD2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS03235
gene id: 163003:CL1_RS03235
uniprot id: I3ZSZ3
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

163003:CL1 RS02040
gene id: 163003:CL1_RS02040
uniprot id: I3ZSC7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

163003:CL1 RS09500
gene id: 163003:CL1_RS09500
uniprot id: I3ZWF3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

163003:CL1 RS03115
gene id: 163003:CL1_RS03115
uniprot id: I3ZSX0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

163003:CL1 RS02785
gene id: 163003:CL1_RS02785
uniprot id: I3ZSR3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

163003:CL1 RS01510
gene id: 163003:CL1_RS01510
uniprot id: I3ZS26
names: Similarity
messages: Belongs to the HepT RNase toxin family.

163003:CL1 RS10290
gene id: 163003:CL1_RS10290
uniprot id: I3ZWW0
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

163003:CL1 RS03675
gene id: 163003:CL1_RS03675
uniprot id: I3ZT79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

163003:CL1 RS06205
gene id: 163003:CL1_RS06205
uniprot id: I3ZUL6
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

163003:CL1 RS02230
gene id: 163003:CL1_RS02230
uniprot id: I3ZSG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

163003:CL1 RS04425
gene id: 163003:CL1_RS04425
uniprot id: I3ZTM0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

163003:CL1 RS04995
gene id: 163003:CL1_RS04995
uniprot id: I3ZTY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

163003:CL1 RS04630
gene id: 163003:CL1_RS04630
uniprot id: I3ZTR1
names: Similarity
messages: Belongs to the UPF0146 family.

163003:CL1 RS06890
gene id: 163003:CL1_RS06890
uniprot id: I3ZUZ4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS03140
gene id: 163003:CL1_RS03140
uniprot id: I3ZSX5
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS00090
gene id: 163003:CL1_RS00090
uniprot id: I3ZRA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

163003:CL1 RS02360
gene id: 163003:CL1_RS02360
uniprot id: I3ZSI2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

163003:CL1 RS04820
gene id: 163003:CL1_RS04820
uniprot id: I3ZTU8
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

163003:CL1 RS10445
gene id: 163003:CL1_RS10445
uniprot id: I3ZWZ0
names: Similarity
messages: Belongs to the peptidase U62 family.

163003:CL1 RS07205
gene id: 163003:CL1_RS07205
uniprot id: I3ZV52
names: Similarity
messages: Belongs to the peptidase C56 family.

163003:CL1 RS03070
gene id: 163003:CL1_RS03070
uniprot id: I3ZSW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

163003:CL1 RS07400
gene id: 163003:CL1_RS07400
uniprot id: I3ZV90
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

163003:CL1 RS02410
gene id: 163003:CL1_RS02410
uniprot id: I3ZSJ1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

163003:CL1 RS00465
gene id: 163003:CL1_RS00465
uniprot id: I3ZRH4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

163003:CL1 RS07070
gene id: 163003:CL1_RS07070
uniprot id: I3ZV28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

163003:CL1 RS09850
gene id: 163003:CL1_RS09850
uniprot id: I3ZWM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

163003:CL1 RS08835
gene id: 163003:CL1_RS08835
uniprot id: I3ZW23
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS00595
gene id: 163003:CL1_RS00595
uniprot id: I3ZRK0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

163003:CL1 RS08485
gene id: 163003:CL1_RS08485
uniprot id: I3ZVV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

163003:CL1 RS08685
gene id: 163003:CL1_RS08685
uniprot id: I3ZVZ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

163003:CL1 RS08530
gene id: 163003:CL1_RS08530
uniprot id: I3ZVW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

163003:CL1 RS04650
gene id: 163003:CL1_RS04650
uniprot id: I3ZTR5
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS08435
gene id: 163003:CL1_RS08435
uniprot id: I3ZVU3
names: Similarity
messages: Belongs to the band 7/mec-2 family.

163003:CL1 RS09000
gene id: 163003:CL1_RS09000
uniprot id: I3ZW51
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

163003:CL1 RS05420
gene id: 163003:CL1_RS05420
uniprot id: I3ZU66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

163003:CL1 RS07035
gene id: 163003:CL1_RS07035
uniprot id: I3ZV22
names: Similarity
messages: Belongs to the UPF0282 family.

163003:CL1 RS05250
gene id: 163003:CL1_RS05250
uniprot id: I3ZU32
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

163003:CL1 RS01855
gene id: 163003:CL1_RS01855
uniprot id: I3ZS92
names: Similarity
messages: Belongs to the HPS/KGPDC family. HPS subfamily.
messages: Belongs to the SIS family. PHI subfamily.

163003:CL1 RS08145
gene id: 163003:CL1_RS08145
uniprot id: I3ZVN7
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

163003:CL1 RS10190
gene id: 163003:CL1_RS10190
uniprot id: I3ZWT9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

163003:CL1 RS02515
gene id: 163003:CL1_RS02515
uniprot id: I3ZSL1
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

163003:CL1 RS00760
gene id: 163003:CL1_RS00760
uniprot id: I3ZRN2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

163003:CL1 RS04170
gene id: 163003:CL1_RS04170
uniprot id: I3ZTH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

163003:CL1 RS06800
gene id: 163003:CL1_RS06800
uniprot id: I3ZUX7
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

163003:CL1 RS08670
gene id: 163003:CL1_RS08670
uniprot id: I3ZVZ0
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS10130
gene id: 163003:CL1_RS10130
uniprot id: I3ZWS8
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS05725
gene id: 163003:CL1_RS05725
uniprot id: I3ZUC5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

163003:CL1 RS06995
gene id: 163003:CL1_RS06995
uniprot id: I3ZV14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S8 family.
messages: Monomer.
messages: Serine protease with a broad substrate specificity.

163003:CL1 RS08180
gene id: 163003:CL1_RS08180
uniprot id: I3ZVP5
names: Similarity
messages: Belongs to the PDCD5 family.

163003:CL1 RS01440
gene id: 163003:CL1_RS01440
uniprot id: I3ZS13
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

163003:CL1 RS09365
gene id: 163003:CL1_RS09365
uniprot id: I3ZWC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

163003:CL1 RS07280
gene id: 163003:CL1_RS07280
uniprot id: I3ZV67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

163003:CL1 RS09185
gene id: 163003:CL1_RS09185
uniprot id: I3ZW88
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

163003:CL1 RS06990
gene id: 163003:CL1_RS06990
uniprot id: I3ZV13
names: Similarity
messages: Belongs to the AOR/FOR family.

163003:CL1 RS04835
gene id: 163003:CL1_RS04835
uniprot id: I3ZTV1
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

163003:CL1 RS04515
gene id: 163003:CL1_RS04515
uniprot id: I3ZTN8
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

163003:CL1 RS06120
gene id: 163003:CL1_RS06120
uniprot id: I3ZUK1
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

163003:CL1 RS09375
gene id: 163003:CL1_RS09375
uniprot id: I3ZWC8
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

163003:CL1 RS03240
gene id: 163003:CL1_RS03240
uniprot id: I3ZSZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

163003:CL1 RS01205
gene id: 163003:CL1_RS01205
uniprot id: I3ZRW7
names: Similarity
messages: Belongs to the AOR/FOR family.

163003:CL1 RS04770
gene id: 163003:CL1_RS04770
uniprot id: I3ZTT8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

163003:CL1 RS03175
gene id: 163003:CL1_RS03175
uniprot id: I3ZSY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

163003:CL1 RS00850
gene id: 163003:CL1_RS00850
uniprot id: I3ZRP9
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS05640
gene id: 163003:CL1_RS05640
uniprot id: I3ZUA8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS05680
gene id: 163003:CL1_RS05680
uniprot id: I3ZUB6
names: Similarity
messages: Belongs to the GbsR family.

163003:CL1 RS00870
gene id: 163003:CL1_RS00870
uniprot id: I3ZRQ3
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS03210
gene id: 163003:CL1_RS03210
uniprot id: I3ZSY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

163003:CL1 RS02930
gene id: 163003:CL1_RS02930
uniprot id: I3ZSU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

163003:CL1 RS02395
gene id: 163003:CL1_RS02395
uniprot id: I3ZSI9
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS05650
gene id: 163003:CL1_RS05650
uniprot id: I3ZUB0
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS09605
gene id: 163003:CL1_RS09605
uniprot id: I3ZWH3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

163003:CL1 RS02335
gene id: 163003:CL1_RS02335
uniprot id: I3ZSH7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

163003:CL1 RS06485
gene id: 163003:CL1_RS06485
uniprot id: I3ZUR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

163003:CL1 RS08545
gene id: 163003:CL1_RS08545
uniprot id: I3ZVW5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

163003:CL1 RS08650
gene id: 163003:CL1_RS08650
uniprot id: I3ZVY6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

163003:CL1 RS10065
gene id: 163003:CL1_RS10065
uniprot id: I3ZWR5
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

163003:CL1 RS07780
gene id: 163003:CL1_RS07780
uniprot id: I3ZVG4
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS04145
gene id: 163003:CL1_RS04145
uniprot id: I3ZTG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

163003:CL1 RS03040
gene id: 163003:CL1_RS03040
uniprot id: I3ZSV9
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

163003:CL1 RS04805
gene id: 163003:CL1_RS04805
uniprot id: I3ZTU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

163003:CL1 RS06165
gene id: 163003:CL1_RS06165
uniprot id: I3ZUK8
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS09970
gene id: 163003:CL1_RS09970
uniprot id: I3ZWP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

163003:CL1 RS01735
gene id: 163003:CL1_RS01735
uniprot id: I3ZS69
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

163003:CL1 RS00535
gene id: 163003:CL1_RS00535
uniprot id: I3ZRI8
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS02110
gene id: 163003:CL1_RS02110
uniprot id: I3ZSE0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS09325
gene id: 163003:CL1_RS09325
uniprot id: I3ZWB8
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

163003:CL1 RS05450
gene id: 163003:CL1_RS05450
uniprot id: I3ZU72
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS05325
gene id: 163003:CL1_RS05325
uniprot id: I3ZU47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

163003:CL1 RS01360
gene id: 163003:CL1_RS01360
uniprot id: I3ZRZ8
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

163003:CL1 RS07710
gene id: 163003:CL1_RS07710
uniprot id: I3ZVF0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

163003:CL1 RS05395
gene id: 163003:CL1_RS05395
uniprot id: I3ZU61
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS02070
gene id: 163003:CL1_RS02070
uniprot id: I3ZSD2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS02620
gene id: 163003:CL1_RS02620
uniprot id: I3ZSN2
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

163003:CL1 RS09165
gene id: 163003:CL1_RS09165
uniprot id: I3ZW84
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

163003:CL1 RS06365
gene id: 163003:CL1_RS06365
uniprot id: I3ZUP4
names: Similarity
messages: Belongs to the UPF0215 family.

163003:CL1 RS05690
gene id: 163003:CL1_RS05690
uniprot id: I3ZUB8
names: Similarity
messages: Belongs to the MoaD family.

163003:CL1 RS01680
gene id: 163003:CL1_RS01680
uniprot id: I3ZS58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

163003:CL1 RS08500
gene id: 163003:CL1_RS08500
uniprot id: I3ZVV7
names: Similarity
messages: Belongs to the UPF0179 family.

163003:CL1 RS01170
gene id: 163003:CL1_RS01170
uniprot id: I3ZRW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

163003:CL1 RS02290
gene id: 163003:CL1_RS02290
uniprot id: I3ZSH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

163003:CL1 RS08760
gene id: 163003:CL1_RS08760
uniprot id: I3ZW08
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS02225
gene id: 163003:CL1_RS02225
uniprot id: I3ZSG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

163003:CL1 RS00585
gene id: 163003:CL1_RS00585
uniprot id: I3ZRJ8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

163003:CL1 RS03090
gene id: 163003:CL1_RS03090
uniprot id: I3ZSW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

163003:CL1 RS00430
gene id: 163003:CL1_RS00430
uniprot id: I3ZRG7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

163003:CL1 RS08310
gene id: 163003:CL1_RS08310
uniprot id: I3ZVS0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

163003:CL1 RS00820
gene id: 163003:CL1_RS00820
uniprot id: I3ZRP4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

163003:CL1 RS05950
gene id: 163003:CL1_RS05950
uniprot id: I3ZUG9
names: Similarity
messages: Belongs to the FrhG family.

163003:CL1 RS06005
gene id: 163003:CL1_RS06005
uniprot id: I3ZUH8
names: Similarity
messages: Belongs to the UPF0111 family.

163003:CL1 RS09640
gene id: 163003:CL1_RS09640
uniprot id: I3ZWI1
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS07055
gene id: 163003:CL1_RS07055
uniprot id: I3ZV26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

163003:CL1 RS02090
gene id: 163003:CL1_RS02090
uniprot id: I3ZSD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

163003:CL1 RS04875
gene id: 163003:CL1_RS04875
uniprot id: I3ZTV9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

163003:CL1 RS06500
gene id: 163003:CL1_RS06500
uniprot id: I3ZUS0
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

163003:CL1 RS01560
gene id: 163003:CL1_RS01560
uniprot id: I3ZS36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

163003:CL1 RS09980
gene id: 163003:CL1_RS09980
uniprot id: I3ZWP8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

163003:CL1 RS02280
gene id: 163003:CL1_RS02280
uniprot id: I3ZSG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

163003:CL1 RS01845
gene id: 163003:CL1_RS01845
uniprot id: I3ZS90
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

163003:CL1 RS06805
gene id: 163003:CL1_RS06805
uniprot id: I3ZUX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

163003:CL1 RS09720
gene id: 163003:CL1_RS09720
uniprot id: I3ZWJ6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS08815
gene id: 163003:CL1_RS08815
uniprot id: I3ZW19
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

163003:CL1 RS07235
gene id: 163003:CL1_RS07235
uniprot id: I3ZV58
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

163003:CL1 RS02425
gene id: 163003:CL1_RS02425
uniprot id: I3ZSJ4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP-dependent glucokinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate.
messages: Cytoplasm

163003:CL1 RS08375
gene id: 163003:CL1_RS08375
uniprot id: I3ZVT1
names: Similarity
messages: Belongs to the DEAD box helicase family.

163003:CL1 RS04375
gene id: 163003:CL1_RS04375
uniprot id: I3ZTL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

163003:CL1 RS10195
gene id: 163003:CL1_RS10195
uniprot id: I3ZWU0
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS02265
gene id: 163003:CL1_RS02265
uniprot id: I3ZSG6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

163003:CL1 RS10025
gene id: 163003:CL1_RS10025
uniprot id: I3ZWQ7
names: Similarity
messages: Belongs to the HypE family.

163003:CL1 RS04165
gene id: 163003:CL1_RS04165
uniprot id: I3ZTH0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

163003:CL1 RS02980
gene id: 163003:CL1_RS02980
uniprot id: I3ZSU9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

163003:CL1 RS01880
gene id: 163003:CL1_RS01880
uniprot id: I3ZS97
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

163003:CL1 RS08590
gene id: 163003:CL1_RS08590
uniprot id: I3ZVX4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS03525
gene id: 163003:CL1_RS03525
uniprot id: I3ZT50
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

163003:CL1 RS07975
gene id: 163003:CL1_RS07975
uniprot id: I3ZVK3
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

163003:CL1 RS08165
gene id: 163003:CL1_RS08165
uniprot id: I3ZVP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

163003:CL1 RS00625
gene id: 163003:CL1_RS00625
uniprot id: I3ZRK6
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS07495
gene id: 163003:CL1_RS07495
uniprot id: I3ZVA9
names: Subcellular Location Annotation
messages: Cytoplasm

163003:CL1 RS05285
gene id: 163003:CL1_RS05285
uniprot id: I3ZU39
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

163003:CL1 RS08395
gene id: 163003:CL1_RS08395
uniprot id: I3ZVT5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

163003:CL1 RS06440
gene id: 163003:CL1_RS06440
uniprot id: I3ZUQ9
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

163003:CL1 RS03965
gene id: 163003:CL1_RS03965
uniprot id: I3ZTD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

163003:CL1 RS04080
gene id: 163003:CL1_RS04080
uniprot id: I3ZTF2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

163003:CL1 RS04005
gene id: 163003:CL1_RS04005
uniprot id: I3ZTD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

163003:CL1 RS01655
gene id: 163003:CL1_RS01655
uniprot id: I3ZS53
names: Similarity
messages: Belongs to the peptidase S49 family.

163003:CL1 RS04305
gene id: 163003:CL1_RS04305
uniprot id: I3ZTJ6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

163003:CL1 RS00175
gene id: 163003:CL1_RS00175
uniprot id: I3ZRB7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS00770
gene id: 163003:CL1_RS00770
uniprot id: I3ZRN4
names: Similarity
messages: Belongs to the RutC family.

163003:CL1 RS07385
gene id: 163003:CL1_RS07385
uniprot id: I3ZV87
names: Subcellular Location Annotation
messages: Cell membrane

163003:CL1 RS02510
gene id: 163003:CL1_RS02510
uniprot id: I3ZSL0
names: Similarity
messages: Belongs to the HypD family.

163003:CL1 RS05675
gene id: 163003:CL1_RS05675
uniprot id: I3ZUB5
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS09905
gene id: 163003:CL1_RS09905
uniprot id: I3ZWN3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

163003:CL1 RS03205
gene id: 163003:CL1_RS03205
uniprot id: I3ZSY8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

163003:CL1 RS06265
gene id: 163003:CL1_RS06265
uniprot id: I3ZUM7
names: Similarity
messages: Belongs to the carbamate kinase family.

163003:CL1 RS03255
gene id: 163003:CL1_RS03255
uniprot id: I3ZSZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

163003:CL1 RS09620
gene id: 163003:CL1_RS09620
uniprot id: I3ZWH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

163003:CL1 RS05335
gene id: 163003:CL1_RS05335
uniprot id: I3ZU49
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

163003:CL1 RS10490
gene id: 163003:CL1_RS10490
uniprot id: I3ZWZ9
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

163003:CL1 RS09430
gene id: 163003:CL1_RS09430
uniprot id: I3ZWD9
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.

163003:CL1 RS08115
gene id: 163003:CL1_RS08115
uniprot id: I3ZVN1
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

163003:CL1 RS07735
gene id: 163003:CL1_RS07735
uniprot id: I3ZVF5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

163003:CL1 RS01690
gene id: 163003:CL1_RS01690
uniprot id: I3ZS60
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS09045
gene id: 163003:CL1_RS09045
uniprot id: I3ZW60
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

163003:CL1 RS02370
gene id: 163003:CL1_RS02370
uniprot id: I3ZSI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

163003:CL1 RS03680
gene id: 163003:CL1_RS03680
uniprot id: I3ZT80
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS10400
gene id: 163003:CL1_RS10400
uniprot id: I3ZWY2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

163003:CL1 RS06135
gene id: 163003:CL1_RS06135
uniprot id: I3ZUK3
names: Similarity
messages: Belongs to the UPF0147 family.

163003:CL1 RS06255
gene id: 163003:CL1_RS06255
uniprot id: I3ZUM5
names: Similarity
messages: Belongs to the AOR/FOR family.

163003:CL1 RS07005
gene id: 163003:CL1_RS07005
uniprot id: I3ZV16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

163003:CL1 RS09400
gene id: 163003:CL1_RS09400
uniprot id: I3ZWD3
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

163003:CL1 RS07515
gene id: 163003:CL1_RS07515
uniprot id: I3ZVB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

163003:CL1 RS00485
gene id: 163003:CL1_RS00485
uniprot id: I3ZRH8
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS02200
gene id: 163003:CL1_RS02200
uniprot id: I3ZSF6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

163003:CL1 RS04115
gene id: 163003:CL1_RS04115
uniprot id: I3ZTF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

163003:CL1 RS01935
gene id: 163003:CL1_RS01935
uniprot id: I3ZSA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

163003:CL1 RS00490
gene id: 163003:CL1_RS00490
uniprot id: I3ZRH9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

163003:CL1 RS04065
gene id: 163003:CL1_RS04065
uniprot id: I3ZTE9
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

163003:CL1 RS00515
gene id: 163003:CL1_RS00515
uniprot id: I3ZRI4
names: Similarity
messages: Belongs to the HypE family.

163003:CL1 RS04775
gene id: 163003:CL1_RS04775
uniprot id: I3ZTT9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

163003:CL1 RS03295
gene id: 163003:CL1_RS03295
uniprot id: I3ZT05
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

163003:CL1 RS03975
gene id: 163003:CL1_RS03975
uniprot id: I3ZTD2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

163003:CL1 RS07955
gene id: 163003:CL1_RS07955
uniprot id: I3ZVJ9
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

163003:CL1 RS00360
gene id: 163003:CL1_RS00360
uniprot id: I3ZRF3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

163003:CL1 RS01380
gene id: 163003:CL1_RS01380
uniprot id: I3ZS02
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

163003:CL1 RS02880
gene id: 163003:CL1_RS02880
uniprot id: I3ZST2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

163003:CL1 RS10270
gene id: 163003:CL1_RS10270
uniprot id: I3ZWV6
names: Subcellular Location Annotation
messages: Cytoplasm

163003:CL1 RS03100
gene id: 163003:CL1_RS03100
uniprot id: I3ZSW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

163003:CL1 RS04110
gene id: 163003:CL1_RS04110
uniprot id: I3ZTF8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS07450
gene id: 163003:CL1_RS07450
uniprot id: I3ZVA0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

163003:CL1 RS05385
gene id: 163003:CL1_RS05385
uniprot id: I3ZU59
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

163003:CL1 RS03775
gene id: 163003:CL1_RS03775
uniprot id: I3ZT96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

163003:CL1 RS09010
gene id: 163003:CL1_RS09010
uniprot id: I3ZW53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

163003:CL1 RS02025
gene id: 163003:CL1_RS02025
uniprot id: I3ZSC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

163003:CL1 RS00440
gene id: 163003:CL1_RS00440
uniprot id: I3ZRG9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

163003:CL1 RS04720
gene id: 163003:CL1_RS04720
uniprot id: I3ZTS8
names: Similarity
messages: Belongs to the UPF0216 family.

163003:CL1 RS00460
gene id: 163003:CL1_RS00460
uniprot id: I3ZRH3
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

163003:CL1 RS01515
gene id: 163003:CL1_RS01515
uniprot id: I3ZS27
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

163003:CL1 RS09995
gene id: 163003:CL1_RS09995
uniprot id: I3ZWQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.
messages: Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
messages: Cytoplasm

163003:CL1 RS06850
gene id: 163003:CL1_RS06850
uniprot id: I3ZUY9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

163003:CL1 RS07165
gene id: 163003:CL1_RS07165
uniprot id: I3ZV44
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

163003:CL1 RS09940
gene id: 163003:CL1_RS09940
uniprot id: I3ZWP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

163003:CL1 RS07860
gene id: 163003:CL1_RS07860
uniprot id: I3ZVI0
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

163003:CL1 RS02595
gene id: 163003:CL1_RS02595
uniprot id: I3ZSM7
names: Similarity
messages: Belongs to the peptidase S8 family.

163003:CL1 RS07655
gene id: 163003:CL1_RS07655
uniprot id: I3ZVD9
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

163003:CL1 RS07130
gene id: 163003:CL1_RS07130
uniprot id: I3ZV37
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS05060
gene id: 163003:CL1_RS05060
uniprot id: I3ZTZ4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

163003:CL1 RS05610
gene id: 163003:CL1_RS05610
uniprot id: I3ZUA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

163003:CL1 RS02430
gene id: 163003:CL1_RS02430
uniprot id: I3ZSJ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal-type GPI family.
messages: Cytoplasm
messages: Homodimer.

163003:CL1 RS08325
gene id: 163003:CL1_RS08325
uniprot id: I3ZVS3
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

163003:CL1 RS08570
gene id: 163003:CL1_RS08570
uniprot id: I3ZVX0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

163003:CL1 RS03615
gene id: 163003:CL1_RS03615
uniprot id: I3ZT67
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

163003:CL1 RS06375
gene id: 163003:CL1_RS06375
uniprot id: I3ZUP6
names: Similarity
messages: Belongs to the acylphosphatase family.

163003:CL1 RS07455
gene id: 163003:CL1_RS07455
uniprot id: I3ZVA1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

163003:CL1 RS02375
gene id: 163003:CL1_RS02375
uniprot id: I3ZSI5
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

163003:CL1 RS01525
gene id: 163003:CL1_RS01525
uniprot id: I3ZS29
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

163003:CL1 RS03690
gene id: 163003:CL1_RS03690
uniprot id: I3ZT82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

163003:CL1 RS08430
gene id: 163003:CL1_RS08430
uniprot id: I3ZVU2
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

163003:CL1 RS09715
gene id: 163003:CL1_RS09715
uniprot id: I3ZWJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

163003:CL1 RS09015
gene id: 163003:CL1_RS09015
uniprot id: I3ZW54
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

163003:CL1 RS04725
gene id: 163003:CL1_RS04725
uniprot id: I3ZTS9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

163003:CL1 RS06955
gene id: 163003:CL1_RS06955
uniprot id: I3ZV07
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

163003:CL1 RS03020
gene id: 163003:CL1_RS03020
uniprot id: I3ZSV6
names: Similarity
messages: Belongs to the FUN14 family.

163003:CL1 RS04845
gene id: 163003:CL1_RS04845
uniprot id: I3ZTV3
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

163003:CL1 RS01000
gene id: 163003:CL1_RS01000
uniprot id: I3ZRS6
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS06475
gene id: 163003:CL1_RS06475
uniprot id: I3ZUR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

163003:CL1 RS04595
gene id: 163003:CL1_RS04595
uniprot id: I3ZTQ4
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

163003:CL1 RS01755
gene id: 163003:CL1_RS01755
uniprot id: I3ZS74
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

163003:CL1 RS03270
gene id: 163003:CL1_RS03270
uniprot id: I3ZT00
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

163003:CL1 RS08440
gene id: 163003:CL1_RS08440
uniprot id: I3ZVU4
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS01175
gene id: 163003:CL1_RS01175
uniprot id: I3ZRW1
names: Similarity
messages: Belongs to the UPF0440 family.

163003:CL1 RS01460
gene id: 163003:CL1_RS01460
uniprot id: I3ZS17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Membrane

163003:CL1 RS06455
gene id: 163003:CL1_RS06455
uniprot id: I3ZUR2
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

163003:CL1 RS04855
gene id: 163003:CL1_RS04855
uniprot id: I3ZTV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

163003:CL1 RS03190
gene id: 163003:CL1_RS03190
uniprot id: I3ZSY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

163003:CL1 RS00450
gene id: 163003:CL1_RS00450
uniprot id: I3ZRH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

163003:CL1 RS07090
gene id: 163003:CL1_RS07090
uniprot id: I3ZV30
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS06465
gene id: 163003:CL1_RS06465
uniprot id: I3ZUR4
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

163003:CL1 RS04315
gene id: 163003:CL1_RS04315
uniprot id: I3ZTJ8
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

163003:CL1 RS03755
gene id: 163003:CL1_RS03755
uniprot id: I3ZT92
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

163003:CL1 RS01015
gene id: 163003:CL1_RS01015
uniprot id: I3ZRS9
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

163003:CL1 RS05445
gene id: 163003:CL1_RS05445
uniprot id: I3ZU71
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

163003:CL1 RS01315
gene id: 163003:CL1_RS01315
uniprot id: I3ZRY9
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS06200
gene id: 163003:CL1_RS06200
uniprot id: I3ZUL5
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

163003:CL1 RS04090
gene id: 163003:CL1_RS04090
uniprot id: I3ZTF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

163003:CL1 RS09035
gene id: 163003:CL1_RS09035
uniprot id: I3ZW58
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

163003:CL1 RS10355
gene id: 163003:CL1_RS10355
uniprot id: I3ZWX3
names: Similarity
messages: Belongs to the UPF0284 family.

163003:CL1 RS06785
gene id: 163003:CL1_RS06785
uniprot id: I3ZUX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

163003:CL1 RS03185
gene id: 163003:CL1_RS03185
uniprot id: I3ZSY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

163003:CL1 RS05685
gene id: 163003:CL1_RS05685
uniprot id: I3ZUB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

163003:CL1 RS05850
gene id: 163003:CL1_RS05850
uniprot id: I3ZUE9
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS01465
gene id: 163003:CL1_RS01465
uniprot id: I3ZS18
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

163003:CL1 RS04150
gene id: 163003:CL1_RS04150
uniprot id: I3ZTG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

163003:CL1 RS05480
gene id: 163003:CL1_RS05480
uniprot id: I3ZU78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

163003:CL1 RS00435
gene id: 163003:CL1_RS00435
uniprot id: I3ZRG8
names: Similarity
messages: Belongs to the UPF0235 family.

163003:CL1 RS06755
gene id: 163003:CL1_RS06755
uniprot id: I3ZUW9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

163003:CL1 RS06745
gene id: 163003:CL1_RS06745
uniprot id: I3ZUW7
names: Similarity
messages: Belongs to the threonine synthase family.

163003:CL1 RS06525
gene id: 163003:CL1_RS06525
uniprot id: I3ZUS5
names: Similarity
messages: Belongs to the UPF0111 family.

163003:CL1 RS06830
gene id: 163003:CL1_RS06830
uniprot id: I3ZUY4
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

163003:CL1 RS05295
gene id: 163003:CL1_RS05295
uniprot id: I3ZU41
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS03765
gene id: 163003:CL1_RS03765
uniprot id: I3ZT94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

163003:CL1 RS07770
gene id: 163003:CL1_RS07770
uniprot id: I3ZVG2
names: Similarity
messages: Belongs to the UPF0128 family.

163003:CL1 RS07180
gene id: 163003:CL1_RS07180
uniprot id: I3ZV47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

163003:CL1 RS08135
gene id: 163003:CL1_RS08135
uniprot id: I3ZVN5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

163003:CL1 RS08380
gene id: 163003:CL1_RS08380
uniprot id: I3ZVT2
names: Similarity
messages: Belongs to the UPF0252 family.

163003:CL1 RS03030
gene id: 163003:CL1_RS03030
uniprot id: I3ZSV8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

163003:CL1 RS07260
gene id: 163003:CL1_RS07260
uniprot id: I3ZV63
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

163003:CL1 RS02615
gene id: 163003:CL1_RS02615
uniprot id: I3ZSN1
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS00905
gene id: 163003:CL1_RS00905
uniprot id: I3ZRQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

163003:CL1 RS06590
gene id: 163003:CL1_RS06590
uniprot id: I3ZUT7
names: Similarity
messages: Belongs to the peptidase U62 family.

163003:CL1 RS00185
gene id: 163003:CL1_RS00185
uniprot id: I3ZRB9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

163003:CL1 RS09105
gene id: 163003:CL1_RS09105
uniprot id: I3ZW72
names: Similarity
messages: Belongs to the UPF0248 family.

163003:CL1 RS07980
gene id: 163003:CL1_RS07980
uniprot id: I3ZVK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

163003:CL1 RS03085
gene id: 163003:CL1_RS03085
uniprot id: I3ZSW6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

163003:CL1 RS00190
gene id: 163003:CL1_RS00190
uniprot id: I3ZRC0
names: Similarity
messages: Belongs to the SAICAR synthetase family.

163003:CL1 RS01410
gene id: 163003:CL1_RS01410
uniprot id: I3ZS08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

163003:CL1 RS03050
gene id: 163003:CL1_RS03050
uniprot id: I3ZSW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

163003:CL1 RS01765
gene id: 163003:CL1_RS01765
uniprot id: I3ZS76
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS05330
gene id: 163003:CL1_RS05330
uniprot id: I3ZU48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

163003:CL1 RS04620
gene id: 163003:CL1_RS04620
uniprot id: I3ZTQ9
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

163003:CL1 RS03170
gene id: 163003:CL1_RS03170
uniprot id: I3ZSY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

163003:CL1 RS00030
gene id: 163003:CL1_RS00030
uniprot id: I3ZR88
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

163003:CL1 RS06605
gene id: 163003:CL1_RS06605
uniprot id: I3ZUU0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

163003:CL1 RS00590
gene id: 163003:CL1_RS00590
uniprot id: I3ZRJ9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

163003:CL1 RS06820
gene id: 163003:CL1_RS06820
uniprot id: I3ZUY2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS06280
gene id: 163003:CL1_RS06280
uniprot id: I3ZUN0
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

163003:CL1 RS05645
gene id: 163003:CL1_RS05645
uniprot id: I3ZUA9
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS09635
gene id: 163003:CL1_RS09635
uniprot id: I3ZWI0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS10180
gene id: 163003:CL1_RS10180
uniprot id: I3ZWT7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

163003:CL1 RS08400
gene id: 163003:CL1_RS08400
uniprot id: I3ZVT6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

163003:CL1 RS05970
gene id: 163003:CL1_RS05970
uniprot id: I3ZUH2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

163003:CL1 RS06765
gene id: 163003:CL1_RS06765
uniprot id: I3ZUX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

163003:CL1 RS09820
gene id: 163003:CL1_RS09820
uniprot id: I3ZWL6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

163003:CL1 RS07715
gene id: 163003:CL1_RS07715
uniprot id: I3ZVF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

163003:CL1 RS00805
gene id: 163003:CL1_RS00805
uniprot id: I3ZRP1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

163003:CL1 RS01035
gene id: 163003:CL1_RS01035
uniprot id: I3ZRT3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

163003:CL1 RS03475
gene id: 163003:CL1_RS03475
uniprot id: I3ZT40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

163003:CL1 RS02835
gene id: 163003:CL1_RS02835
uniprot id: I3ZSS3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

163003:CL1 RS01740
gene id: 163003:CL1_RS01740
uniprot id: I3ZS70
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Cytoplasm
messages: Homotetramer.

163003:CL1 RS10120
gene id: 163003:CL1_RS10120
uniprot id: I3ZWS6
names: Similarity
messages: Belongs to the IMPACT family.

163003:CL1 RS00715
gene id: 163003:CL1_RS00715
uniprot id: I3ZRM3
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

163003:CL1 RS09195
gene id: 163003:CL1_RS09195
uniprot id: I3ZW91
names: Similarity
messages: Belongs to the UPF0251 family.

163003:CL1 RS08280
gene id: 163003:CL1_RS08280
uniprot id: I3ZVR5
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

163003:CL1 RS09805
gene id: 163003:CL1_RS09805
uniprot id: I3ZWL3
names: Similarity
messages: Belongs to the UPF0045 family.

163003:CL1 RS02260
gene id: 163003:CL1_RS02260
uniprot id: I3ZSG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

163003:CL1 RS02095
gene id: 163003:CL1_RS02095
uniprot id: I3ZSD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

163003:CL1 RS02450
gene id: 163003:CL1_RS02450
uniprot id: I3ZSJ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

163003:CL1 RS01905
gene id: 163003:CL1_RS01905
uniprot id: I3ZSA2
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

163003:CL1 RS09775
gene id: 163003:CL1_RS09775
uniprot id: I3ZWK7
names: Similarity
messages: Belongs to the pyruvate kinase family.

163003:CL1 RS10230
gene id: 163003:CL1_RS10230
uniprot id: I3ZWU8
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

163003:CL1 RS03545
gene id: 163003:CL1_RS03545
uniprot id: I3ZT54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

163003:CL1 RS08915
gene id: 163003:CL1_RS08915
uniprot id: I3ZW38
names: Similarity
messages: Belongs to the AAA ATPase family.

163003:CL1 RS06700
gene id: 163003:CL1_RS06700
uniprot id: I3ZUV8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

163003:CL1 RS05245
gene id: 163003:CL1_RS05245
uniprot id: I3ZU31
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

163003:CL1 RS00975
gene id: 163003:CL1_RS00975
uniprot id: I3ZRS1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

163003:CL1 RS01665
gene id: 163003:CL1_RS01665
uniprot id: I3ZS55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

163003:CL1 RS10405
gene id: 163003:CL1_RS10405
uniprot id: I3ZWY3
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

163003:CL1 RS08765
gene id: 163003:CL1_RS08765
uniprot id: I3ZW09
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

163003:CL1 RS02255
gene id: 163003:CL1_RS02255
uniprot id: I3ZSG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

163003:CL1 RS09815
gene id: 163003:CL1_RS09815
uniprot id: I3ZWL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

163003:CL1 RS07020
gene id: 163003:CL1_RS07020
uniprot id: I3ZV19
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

163003:CL1 RS02905
gene id: 163003:CL1_RS02905
uniprot id: I3ZST6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

163003:CL1 RS03285
gene id: 163003:CL1_RS03285
uniprot id: I3ZT03
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

163003:CL1 RS02270
gene id: 163003:CL1_RS02270
uniprot id: I3ZSG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

163003:CL1 RS07660
gene id: 163003:CL1_RS07660
uniprot id: I3ZVE0
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

163003:CL1 RS00115
gene id: 163003:CL1_RS00115
uniprot id: I3ZRA5
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS07140
gene id: 163003:CL1_RS07140
uniprot id: I3ZV39
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

163003:CL1 RS04275
gene id: 163003:CL1_RS04275
uniprot id: I3ZTJ2
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

163003:CL1 RS00795
gene id: 163003:CL1_RS00795
uniprot id: I3ZRN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

163003:CL1 RS03165
gene id: 163003:CL1_RS03165
uniprot id: I3ZSY0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

163003:CL1 RS08140
gene id: 163003:CL1_RS08140
uniprot id: I3ZVN6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

163003:CL1 RS09785
gene id: 163003:CL1_RS09785
uniprot id: I3ZWK9
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS04070
gene id: 163003:CL1_RS04070
uniprot id: I3ZTF0
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

163003:CL1 RS06725
gene id: 163003:CL1_RS06725
uniprot id: I3ZUW3
names: Subcellular Location Annotation
messages: Membrane

163003:CL1 RS00615
gene id: 163003:CL1_RS00615
uniprot id: I3ZRK4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

163003:CL1 RS10000
gene id: 163003:CL1_RS10000
uniprot id: I3ZWQ2
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

163003:CL1 RS01125
gene id: 163003:CL1_RS01125
uniprot id: I3ZRV1
names: Similarity
messages: Belongs to the RuvB family.

163003:CL1 RS06545
gene id: 163003:CL1_RS06545
uniprot id: I3ZUS9
names: Similarity
messages: Belongs to the malic enzymes family.

163003:CL1 RS08340
gene id: 163003:CL1_RS08340
uniprot id: I3ZVS6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

163003:CL1 RS01430
gene id: 163003:CL1_RS01430
uniprot id: I3ZS12
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

163003:CL1 RS09280
gene id: 163003:CL1_RS09280
uniprot id: I3ZWA8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

163003:CL1 RS03340
gene id: 163003:CL1_RS03340
uniprot id: I3ZT14
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

163003:CL1 RS05410
gene id: 163003:CL1_RS05410
uniprot id: I3ZU64
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

163003:CL1 RS04250
gene id: 163003:CL1_RS04250
uniprot id: I3ZTI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

163003:CL1 RS06445
gene id: 163003:CL1_RS06445
uniprot id: I3ZUR0
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.