158189:SPIBUDDY RS03875
gene id: 158189:SPIBUDDY_RS03875
uniprot id: F0RYA1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

158189:SPIBUDDY RS07100
gene id: 158189:SPIBUDDY_RS07100
uniprot id: F0RZ10
names: Similarity
messages: Belongs to the RibF family.

158189:SPIBUDDY RS07075
gene id: 158189:SPIBUDDY_RS07075
uniprot id: F0RZ05
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS09610
gene id: 158189:SPIBUDDY_RS09610
uniprot id: F0RWT3
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

158189:SPIBUDDY RS15115
gene id: 158189:SPIBUDDY_RS15115
uniprot id: F0RZP1
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

158189:SPIBUDDY RS08065
gene id: 158189:SPIBUDDY_RS08065
uniprot id: F0RZC7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

158189:SPIBUDDY RS08485
gene id: 158189:SPIBUDDY_RS08485
uniprot id: F0RZE2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mg(2+). Can also accept Mn(2+).

158189:SPIBUDDY RS11625
gene id: 158189:SPIBUDDY_RS11625
uniprot id: F0RSJ4
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

158189:SPIBUDDY RS13815
gene id: 158189:SPIBUDDY_RS13815
uniprot id: F0RRT8
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

158189:SPIBUDDY RS00975
gene id: 158189:SPIBUDDY_RS00975
uniprot id: F0RXI6
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS07115
gene id: 158189:SPIBUDDY_RS07115
uniprot id: F0RZ13
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

158189:SPIBUDDY RS11645
gene id: 158189:SPIBUDDY_RS11645
uniprot id: F0RSJ8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

158189:SPIBUDDY RS00890
gene id: 158189:SPIBUDDY_RS00890
uniprot id: F0RXG9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

158189:SPIBUDDY RS06420
gene id: 158189:SPIBUDDY_RS06420
uniprot id: F0RYV1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

158189:SPIBUDDY RS09885
gene id: 158189:SPIBUDDY_RS09885
uniprot id: F0RWY5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS10885
gene id: 158189:SPIBUDDY_RS10885
uniprot id: F0RT14
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS06480
gene id: 158189:SPIBUDDY_RS06480
uniprot id: F0RYW3
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

158189:SPIBUDDY RS07205
gene id: 158189:SPIBUDDY_RS07205
uniprot id: F0RZ31
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS09185
gene id: 158189:SPIBUDDY_RS09185
uniprot id: F0RWJ9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

158189:SPIBUDDY RS05190
gene id: 158189:SPIBUDDY_RS05190
uniprot id: F0RYL3
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

158189:SPIBUDDY RS06135
gene id: 158189:SPIBUDDY_RS06135
uniprot id: F0RVP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

158189:SPIBUDDY RS07150
gene id: 158189:SPIBUDDY_RS07150
uniprot id: F0RZ20
names: Caution
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

158189:SPIBUDDY RS08285
gene id: 158189:SPIBUDDY_RS08285
uniprot id: F0RW96
names: Similarity
messages: Belongs to the KdgT transporter family.

158189:SPIBUDDY RS00340
gene id: 158189:SPIBUDDY_RS00340
uniprot id: F0RX63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.
messages: The complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

158189:SPIBUDDY RS11175
gene id: 158189:SPIBUDDY_RS11175
uniprot id: F0RSW6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

158189:SPIBUDDY RS13805
gene id: 158189:SPIBUDDY_RS13805
uniprot id: F0RRT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS04830
gene id: 158189:SPIBUDDY_RS04830
uniprot id: F0RV64
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

158189:SPIBUDDY RS10660
gene id: 158189:SPIBUDDY_RS10660
uniprot id: F0RTL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

158189:SPIBUDDY RS04405
gene id: 158189:SPIBUDDY_RS04405
uniprot id: F0RYD1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS06095
gene id: 158189:SPIBUDDY_RS06095
uniprot id: F0RVN7
names: Similarity
messages: Belongs to the FemABX family.

158189:SPIBUDDY RS05015
gene id: 158189:SPIBUDDY_RS05015
uniprot id: F0RVA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

158189:SPIBUDDY RS13650
gene id: 158189:SPIBUDDY_RS13650
uniprot id: F0RRS4
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS08630
gene id: 158189:SPIBUDDY_RS08630
uniprot id: F0RZH1
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS11755
gene id: 158189:SPIBUDDY_RS11755
uniprot id: F0RSN2
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

158189:SPIBUDDY RS13655
gene id: 158189:SPIBUDDY_RS13655
uniprot id: F0RRS5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

158189:SPIBUDDY RS09840
gene id: 158189:SPIBUDDY_RS09840
uniprot id: F0RWX7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

158189:SPIBUDDY RS00415
gene id: 158189:SPIBUDDY_RS00415
uniprot id: F0RX78
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

158189:SPIBUDDY RS11635
gene id: 158189:SPIBUDDY_RS11635
uniprot id: F0RSJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

158189:SPIBUDDY RS07840
gene id: 158189:SPIBUDDY_RS07840
uniprot id: F0RZ82
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS09135
gene id: 158189:SPIBUDDY_RS09135
uniprot id: F0RWI9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

158189:SPIBUDDY RS02005
gene id: 158189:SPIBUDDY_RS02005
uniprot id: F0RXV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS14160
gene id: 158189:SPIBUDDY_RS14160
uniprot id: F0RS06
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

158189:SPIBUDDY RS05790
gene id: 158189:SPIBUDDY_RS05790
uniprot id: F0RVH9
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

158189:SPIBUDDY RS02210
gene id: 158189:SPIBUDDY_RS02210
uniprot id: F0RUB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS00025
gene id: 158189:SPIBUDDY_RS00025
uniprot id: F0RX01
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

158189:SPIBUDDY RS09120
gene id: 158189:SPIBUDDY_RS09120
uniprot id: F0RWI6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

158189:SPIBUDDY RS14445
gene id: 158189:SPIBUDDY_RS14445
uniprot id: F0RS65
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

158189:SPIBUDDY RS07695
gene id: 158189:SPIBUDDY_RS07695
uniprot id: F0RW48
names: Similarity
messages: Belongs to the disproportionating enzyme family.

158189:SPIBUDDY RS15790
gene id: 158189:SPIBUDDY_RS15790
uniprot id: F0RSW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

158189:SPIBUDDY RS07020
gene id: 158189:SPIBUDDY_RS07020
uniprot id: F0RYZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

158189:SPIBUDDY RS14415
gene id: 158189:SPIBUDDY_RS14415
uniprot id: F0RS59
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

158189:SPIBUDDY RS13635
gene id: 158189:SPIBUDDY_RS13635
uniprot id: F0RSP8
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

158189:SPIBUDDY RS06620
gene id: 158189:SPIBUDDY_RS06620
uniprot id: F0RVR1
names: Subcellular Location Annotation
messages: Nucleus

158189:SPIBUDDY RS07225
gene id: 158189:SPIBUDDY_RS07225
uniprot id: F0RZ35
names: Function
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.

158189:SPIBUDDY RS11110
gene id: 158189:SPIBUDDY_RS11110
uniprot id: F0RSV5
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS00345
gene id: 158189:SPIBUDDY_RS00345
uniprot id: F0RX64
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS09795
gene id: 158189:SPIBUDDY_RS09795
uniprot id: F0RWW8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

158189:SPIBUDDY RS10825
gene id: 158189:SPIBUDDY_RS10825
uniprot id: F0RT04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS08705
gene id: 158189:SPIBUDDY_RS08705
uniprot id: F0RZI5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

158189:SPIBUDDY RS04190
gene id: 158189:SPIBUDDY_RS04190
uniprot id: F0RV11
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

158189:SPIBUDDY RS09160
gene id: 158189:SPIBUDDY_RS09160
uniprot id: F0RWJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

158189:SPIBUDDY RS14710
gene id: 158189:SPIBUDDY_RS14710
uniprot id: F0RTQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

158189:SPIBUDDY RS14665
gene id: 158189:SPIBUDDY_RS14665
uniprot id: F0RS99
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

158189:SPIBUDDY RS05980
gene id: 158189:SPIBUDDY_RS05980
uniprot id: F0RVL4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

158189:SPIBUDDY RS06210
gene id: 158189:SPIBUDDY_RS06210
uniprot id: F0RYR6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

158189:SPIBUDDY RS05470
gene id: 158189:SPIBUDDY_RS05470
uniprot id: F0RVC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

158189:SPIBUDDY RS04940
gene id: 158189:SPIBUDDY_RS04940
uniprot id: F0RV86
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

158189:SPIBUDDY RS02595
gene id: 158189:SPIBUDDY_RS02595
uniprot id: F0RUJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS11050
gene id: 158189:SPIBUDDY_RS11050
uniprot id: F0RSU3
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

158189:SPIBUDDY RS08520
gene id: 158189:SPIBUDDY_RS08520
uniprot id: F0RZE9
names: Similarity
messages: Belongs to the FemABX family.

158189:SPIBUDDY RS08815
gene id: 158189:SPIBUDDY_RS08815
uniprot id: F0RWC6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

158189:SPIBUDDY RS07165
gene id: 158189:SPIBUDDY_RS07165
uniprot id: F0RZ23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

158189:SPIBUDDY RS11620
gene id: 158189:SPIBUDDY_RS11620
uniprot id: F0RSJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

158189:SPIBUDDY RS04575
gene id: 158189:SPIBUDDY_RS04575
uniprot id: F0RYG4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

158189:SPIBUDDY RS07105
gene id: 158189:SPIBUDDY_RS07105
uniprot id: F0RZ11
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

158189:SPIBUDDY RS13595
gene id: 158189:SPIBUDDY_RS13595
uniprot id: F0RSP0
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

158189:SPIBUDDY RS00430
gene id: 158189:SPIBUDDY_RS00430
uniprot id: F0RX81
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

158189:SPIBUDDY RS10290
gene id: 158189:SPIBUDDY_RS10290
uniprot id: F0RTT2
names: Similarity
messages: Belongs to the UPF0047 family.

158189:SPIBUDDY RS09115
gene id: 158189:SPIBUDDY_RS09115
uniprot id: F0RWI5
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS11420
gene id: 158189:SPIBUDDY_RS11420
uniprot id: F0RTY9
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

158189:SPIBUDDY RS00365
gene id: 158189:SPIBUDDY_RS00365
uniprot id: F0RX68
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

158189:SPIBUDDY RS13935
gene id: 158189:SPIBUDDY_RS13935
uniprot id: F0RRW2
names: Similarity
messages: Belongs to the pyruvate kinase family.

158189:SPIBUDDY RS05945
gene id: 158189:SPIBUDDY_RS05945
uniprot id: F0RVK7
names: Similarity
messages: Belongs to the glutamine synthetase family.

158189:SPIBUDDY RS01790
gene id: 158189:SPIBUDDY_RS01790
uniprot id: F0RXR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS04410
gene id: 158189:SPIBUDDY_RS04410
uniprot id: F0RYD2
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS12845
gene id: 158189:SPIBUDDY_RS12845
uniprot id: F0RSF3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

158189:SPIBUDDY RS10220
gene id: 158189:SPIBUDDY_RS10220
uniprot id: F0RTW2
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS11135
gene id: 158189:SPIBUDDY_RS11135
uniprot id: F0RSX4
names: Similarity
messages: Belongs to the peptidase M20A family.

158189:SPIBUDDY RS08530
gene id: 158189:SPIBUDDY_RS08530
uniprot id: F0RZF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

158189:SPIBUDDY RS07735
gene id: 158189:SPIBUDDY_RS07735
uniprot id: F0RZ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS02050
gene id: 158189:SPIBUDDY_RS02050
uniprot id: F0RXW8
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

158189:SPIBUDDY RS04600
gene id: 158189:SPIBUDDY_RS04600
uniprot id: F0RYG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

158189:SPIBUDDY RS09100
gene id: 158189:SPIBUDDY_RS09100
uniprot id: F0RWI2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

158189:SPIBUDDY RS02340
gene id: 158189:SPIBUDDY_RS02340
uniprot id: F0RUE0
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

158189:SPIBUDDY RS10850
gene id: 158189:SPIBUDDY_RS10850
uniprot id: F0RT09
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

158189:SPIBUDDY RS15485
gene id: 158189:SPIBUDDY_RS15485
uniprot id: F0RZV8
names: Similarity
messages: Belongs to the ParB family.

158189:SPIBUDDY RS03235
gene id: 158189:SPIBUDDY_RS03235
uniprot id: F0RUP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS06265
gene id: 158189:SPIBUDDY_RS06265
uniprot id: F0RYS7
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

158189:SPIBUDDY RS12205
gene id: 158189:SPIBUDDY_RS12205
uniprot id: F0RRH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS12950
gene id: 158189:SPIBUDDY_RS12950
uniprot id: F0RT69
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

158189:SPIBUDDY RS05670
gene id: 158189:SPIBUDDY_RS05670
uniprot id: F0RVF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.

158189:SPIBUDDY RS07390
gene id: 158189:SPIBUDDY_RS07390
uniprot id: F0RVY9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

158189:SPIBUDDY RS06275
gene id: 158189:SPIBUDDY_RS06275
uniprot id: F0RYS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

158189:SPIBUDDY RS00385
gene id: 158189:SPIBUDDY_RS00385
uniprot id: F0RX72
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS08985
gene id: 158189:SPIBUDDY_RS08985
uniprot id: F0RWF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS05880
gene id: 158189:SPIBUDDY_RS05880
uniprot id: F0RVJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS06690
gene id: 158189:SPIBUDDY_RS06690
uniprot id: F0RVS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

158189:SPIBUDDY RS13745
gene id: 158189:SPIBUDDY_RS13745
uniprot id: F0RSC1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

158189:SPIBUDDY RS02970
gene id: 158189:SPIBUDDY_RS02970
uniprot id: F0RY03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

158189:SPIBUDDY RS03330
gene id: 158189:SPIBUDDY_RS03330
uniprot id: F0RUR4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

158189:SPIBUDDY RS09025
gene id: 158189:SPIBUDDY_RS09025
uniprot id: F0RWG6
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

158189:SPIBUDDY RS14240
gene id: 158189:SPIBUDDY_RS14240
uniprot id: F0RS22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

158189:SPIBUDDY RS12920
gene id: 158189:SPIBUDDY_RS12920
uniprot id: F0RTC4
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS04310
gene id: 158189:SPIBUDDY_RS04310
uniprot id: F0RV35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS14355
gene id: 158189:SPIBUDDY_RS14355
uniprot id: F0RS47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

158189:SPIBUDDY RS05910
gene id: 158189:SPIBUDDY_RS05910
uniprot id: F0RVK0
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

158189:SPIBUDDY RS08760
gene id: 158189:SPIBUDDY_RS08760
uniprot id: F0RZJ5
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

158189:SPIBUDDY RS05400
gene id: 158189:SPIBUDDY_RS05400
uniprot id: F0RYQ6
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

158189:SPIBUDDY RS09620
gene id: 158189:SPIBUDDY_RS09620
uniprot id: F0RWT5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

158189:SPIBUDDY RS10180
gene id: 158189:SPIBUDDY_RS10180
uniprot id: F0RTV4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS05805
gene id: 158189:SPIBUDDY_RS05805
uniprot id: F0RVI2
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

158189:SPIBUDDY RS11345
gene id: 158189:SPIBUDDY_RS11345
uniprot id: F0RTX4
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS01710
gene id: 158189:SPIBUDDY_RS01710
uniprot id: F0RU93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS15310
gene id: 158189:SPIBUDDY_RS15310
uniprot id: F0RZS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS11675
gene id: 158189:SPIBUDDY_RS11675
uniprot id: F0RSK5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

158189:SPIBUDDY RS15175
gene id: 158189:SPIBUDDY_RS15175
uniprot id: F0RZQ2
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

158189:SPIBUDDY RS11790
gene id: 158189:SPIBUDDY_RS11790
uniprot id: F0RSM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

158189:SPIBUDDY RS01090
gene id: 158189:SPIBUDDY_RS01090
uniprot id: F0RXK9
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

158189:SPIBUDDY RS14660
gene id: 158189:SPIBUDDY_RS14660
uniprot id: F0RS98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

158189:SPIBUDDY RS08955
gene id: 158189:SPIBUDDY_RS08955
uniprot id: F0RWF2
names: Similarity
messages: Belongs to the UPF0178 family.

158189:SPIBUDDY RS06725
gene id: 158189:SPIBUDDY_RS06725
uniprot id: F0RVT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS10600
gene id: 158189:SPIBUDDY_RS10600
uniprot id: F0RTJ9
names: Similarity
messages: Belongs to the LacAB/RpiB family.

158189:SPIBUDDY RS05105
gene id: 158189:SPIBUDDY_RS05105
uniprot id: F0RYJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS00905
gene id: 158189:SPIBUDDY_RS00905
uniprot id: F0RXH2
names: Similarity
messages: Belongs to the DapA family.

158189:SPIBUDDY RS04445
gene id: 158189:SPIBUDDY_RS04445
uniprot id: F0RYD9
names: Similarity
messages: Belongs to the CobT family.

158189:SPIBUDDY RS07110
gene id: 158189:SPIBUDDY_RS07110
uniprot id: F0RZ12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

158189:SPIBUDDY RS07050
gene id: 158189:SPIBUDDY_RS07050
uniprot id: F0RZ00
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

158189:SPIBUDDY RS12715
gene id: 158189:SPIBUDDY_RS12715
uniprot id: F0RSC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS01815
gene id: 158189:SPIBUDDY_RS01815
uniprot id: F0RXS3
names: Similarity
messages: Belongs to the polysaccharide synthase family.

158189:SPIBUDDY RS02215
gene id: 158189:SPIBUDDY_RS02215
uniprot id: F0RUB6
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

158189:SPIBUDDY RS08920
gene id: 158189:SPIBUDDY_RS08920
uniprot id: F0RWE5
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

158189:SPIBUDDY RS13785
gene id: 158189:SPIBUDDY_RS13785
uniprot id: F0RRT2
names: Similarity
messages: Belongs to the ice-binding protein family.

158189:SPIBUDDY RS11030
gene id: 158189:SPIBUDDY_RS11030
uniprot id: F0RST9
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS00630
gene id: 158189:SPIBUDDY_RS00630
uniprot id: F0RXB9
names: Similarity
messages: Belongs to the asparagine synthetase family.

158189:SPIBUDDY RS07095
gene id: 158189:SPIBUDDY_RS07095
uniprot id: F0RZ09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

158189:SPIBUDDY RS05810
gene id: 158189:SPIBUDDY_RS05810
uniprot id: F0RVI3
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

158189:SPIBUDDY RS13715
gene id: 158189:SPIBUDDY_RS13715
uniprot id: F0RSB4
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

158189:SPIBUDDY RS12530
gene id: 158189:SPIBUDDY_RS12530
uniprot id: F0RRN2
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

158189:SPIBUDDY RS07665
gene id: 158189:SPIBUDDY_RS07665
uniprot id: F0RW42
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

158189:SPIBUDDY RS02835
gene id: 158189:SPIBUDDY_RS02835
uniprot id: F0RUN9
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

158189:SPIBUDDY RS08785
gene id: 158189:SPIBUDDY_RS08785
uniprot id: F0RZJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

158189:SPIBUDDY RS00335
gene id: 158189:SPIBUDDY_RS00335
uniprot id: F0RX62
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Periplasm
messages: The ABC transporter complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

158189:SPIBUDDY RS09445
gene id: 158189:SPIBUDDY_RS09445
uniprot id: F0RWQ0
names: Subcellular Location Annotation
messages: Virion

158189:SPIBUDDY RS12730
gene id: 158189:SPIBUDDY_RS12730
uniprot id: F0RSD1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

158189:SPIBUDDY RS06455
gene id: 158189:SPIBUDDY_RS06455
uniprot id: F0RYV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS08245
gene id: 158189:SPIBUDDY_RS08245
uniprot id: F0RW88
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

158189:SPIBUDDY RS10970
gene id: 158189:SPIBUDDY_RS10970
uniprot id: F0RSS8
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

158189:SPIBUDDY RS03995
gene id: 158189:SPIBUDDY_RS03995
uniprot id: F0RUX2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

158189:SPIBUDDY RS09995
gene id: 158189:SPIBUDDY_RS09995
uniprot id: F0RZX7
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS01835
gene id: 158189:SPIBUDDY_RS01835
uniprot id: F0RXS7
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

158189:SPIBUDDY RS08350
gene id: 158189:SPIBUDDY_RS08350
uniprot id: F0RWA9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS14790
gene id: 158189:SPIBUDDY_RS14790
uniprot id: F0RTN0
names: Similarity
messages: Belongs to the YggT family.

158189:SPIBUDDY RS13605
gene id: 158189:SPIBUDDY_RS13605
uniprot id: F0RSP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

158189:SPIBUDDY RS01795
gene id: 158189:SPIBUDDY_RS01795
uniprot id: F0RXR9
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

158189:SPIBUDDY RS02350
gene id: 158189:SPIBUDDY_RS02350
uniprot id: F0RUE2
names: Similarity
messages: Belongs to the fabD family.

158189:SPIBUDDY RS13995
gene id: 158189:SPIBUDDY_RS13995
uniprot id: F0RRX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

158189:SPIBUDDY RS14680
gene id: 158189:SPIBUDDY_RS14680
uniprot id: F0RSA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

158189:SPIBUDDY RS05555
gene id: 158189:SPIBUDDY_RS05555
uniprot id: F0RVD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P(II) protein family.
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

158189:SPIBUDDY RS09060
gene id: 158189:SPIBUDDY_RS09060
uniprot id: F0RWH3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

158189:SPIBUDDY RS10215
gene id: 158189:SPIBUDDY_RS10215
uniprot id: F0RTW1
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS04730
gene id: 158189:SPIBUDDY_RS04730
uniprot id: F0RV43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS04795
gene id: 158189:SPIBUDDY_RS04795
uniprot id: F0RV57
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS14525
gene id: 158189:SPIBUDDY_RS14525
uniprot id: F0RS80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS10340
gene id: 158189:SPIBUDDY_RS10340
uniprot id: F0RTU0
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS00010
gene id: 158189:SPIBUDDY_RS00010
uniprot id: F0RWZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

158189:SPIBUDDY RS07465
gene id: 158189:SPIBUDDY_RS07465
uniprot id: F0RW04
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS14440
gene id: 158189:SPIBUDDY_RS14440
uniprot id: F0RS64
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

158189:SPIBUDDY RS01740
gene id: 158189:SPIBUDDY_RS01740
uniprot id: F0RXQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS07255
gene id: 158189:SPIBUDDY_RS07255
uniprot id: F0RZ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS03845
gene id: 158189:SPIBUDDY_RS03845
uniprot id: F0RY95
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS10470
gene id: 158189:SPIBUDDY_RS10470
uniprot id: F0RZY3
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS00805
gene id: 158189:SPIBUDDY_RS00805
uniprot id: F0RXF3
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS01605
gene id: 158189:SPIBUDDY_RS01605
uniprot id: F0RU73
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

158189:SPIBUDDY RS00445
gene id: 158189:SPIBUDDY_RS00445
uniprot id: F0RX84
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

158189:SPIBUDDY RS06115
gene id: 158189:SPIBUDDY_RS06115
uniprot id: F0RVP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

158189:SPIBUDDY RS14425
gene id: 158189:SPIBUDDY_RS14425
uniprot id: F0RS61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

158189:SPIBUDDY RS02000
gene id: 158189:SPIBUDDY_RS02000
uniprot id: F0RXV8
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

158189:SPIBUDDY RS08935
gene id: 158189:SPIBUDDY_RS08935
uniprot id: F0RWE8
names: Similarity
messages: Belongs to the ArsC family.

158189:SPIBUDDY RS15340
gene id: 158189:SPIBUDDY_RS15340
uniprot id: F0RZT5
names: Subcellular Location Annotation
messages: Nucleus

158189:SPIBUDDY RS14265
gene id: 158189:SPIBUDDY_RS14265
uniprot id: F0RS27
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

158189:SPIBUDDY RS00320
gene id: 158189:SPIBUDDY_RS00320
uniprot id: F0RX59
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

158189:SPIBUDDY RS02900
gene id: 158189:SPIBUDDY_RS02900
uniprot id: F0RXZ0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

158189:SPIBUDDY RS03360
gene id: 158189:SPIBUDDY_RS03360
uniprot id: F0RUS0
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

158189:SPIBUDDY RS03490
gene id: 158189:SPIBUDDY_RS03490
uniprot id: F0RUU5
names: Similarity
messages: Belongs to the UPF0758 family.

158189:SPIBUDDY RS03860
gene id: 158189:SPIBUDDY_RS03860
uniprot id: F0RY98
names: Similarity
messages: Belongs to the disproportionating enzyme family.

158189:SPIBUDDY RS14850
gene id: 158189:SPIBUDDY_RS14850
uniprot id: F0RTP2
names: Similarity
messages: Belongs to the PspA/IM30 family.

158189:SPIBUDDY RS06405
gene id: 158189:SPIBUDDY_RS06405
uniprot id: F0RYU8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

158189:SPIBUDDY RS02745
gene id: 158189:SPIBUDDY_RS02745
uniprot id: F0RUM2
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.

158189:SPIBUDDY RS04200
gene id: 158189:SPIBUDDY_RS04200
uniprot id: F0RV13
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

158189:SPIBUDDY RS05915
gene id: 158189:SPIBUDDY_RS05915
uniprot id: F0RVK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
messages: Cytoplasm

158189:SPIBUDDY RS02775
gene id: 158189:SPIBUDDY_RS02775
uniprot id: F0RUM8
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

158189:SPIBUDDY RS14805
gene id: 158189:SPIBUDDY_RS14805
uniprot id: F0RTN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-ACP thioesterase family.
messages: chloroplast

158189:SPIBUDDY RS06105
gene id: 158189:SPIBUDDY_RS06105
uniprot id: F0RVN9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

158189:SPIBUDDY RS08740
gene id: 158189:SPIBUDDY_RS08740
uniprot id: F0RZJ1
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

158189:SPIBUDDY RS05550
gene id: 158189:SPIBUDDY_RS05550
uniprot id: F0RVD1
names: Similarity
messages: Belongs to the peptidase M29 family.

158189:SPIBUDDY RS08615
gene id: 158189:SPIBUDDY_RS08615
uniprot id: F0RZG8
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS07825
gene id: 158189:SPIBUDDY_RS07825
uniprot id: F0RZ79
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

158189:SPIBUDDY RS04680
gene id: 158189:SPIBUDDY_RS04680
uniprot id: F0RYI4
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS05370
gene id: 158189:SPIBUDDY_RS05370
uniprot id: F0RYQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS00540
gene id: 158189:SPIBUDDY_RS00540
uniprot id: F0RXA2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS06650
gene id: 158189:SPIBUDDY_RS06650
uniprot id: F0RVR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

158189:SPIBUDDY RS00230
gene id: 158189:SPIBUDDY_RS00230
uniprot id: F0RX41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

158189:SPIBUDDY RS08180
gene id: 158189:SPIBUDDY_RS08180
uniprot id: F0RW75
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS06645
gene id: 158189:SPIBUDDY_RS06645
uniprot id: F0RVR6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

158189:SPIBUDDY RS10080
gene id: 158189:SPIBUDDY_RS10080
uniprot id: F0RTR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

158189:SPIBUDDY RS10110
gene id: 158189:SPIBUDDY_RS10110
uniprot id: F0RTS1
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

158189:SPIBUDDY RS01785
gene id: 158189:SPIBUDDY_RS01785
uniprot id: F0RXR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS11340
gene id: 158189:SPIBUDDY_RS11340
uniprot id: F0RTX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases.
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

158189:SPIBUDDY RS13415
gene id: 158189:SPIBUDDY_RS13415
uniprot id: F0RT19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS05815
gene id: 158189:SPIBUDDY_RS05815
uniprot id: F0RVI4
names: Similarity
messages: Belongs to the universal stress protein A family.

158189:SPIBUDDY RS03890
gene id: 158189:SPIBUDDY_RS03890
uniprot id: F0RYA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

158189:SPIBUDDY RS11740
gene id: 158189:SPIBUDDY_RS11740
uniprot id: F0RSL9
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

158189:SPIBUDDY RS00105
gene id: 158189:SPIBUDDY_RS00105
uniprot id: F0RX17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

158189:SPIBUDDY RS14330
gene id: 158189:SPIBUDDY_RS14330
uniprot id: F0RS42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

158189:SPIBUDDY RS04115
gene id: 158189:SPIBUDDY_RS04115
uniprot id: F0RUZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell inner membrane
messages: Probably functions as a manganese efflux pump.

158189:SPIBUDDY RS14210
gene id: 158189:SPIBUDDY_RS14210
uniprot id: F0RS16
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

158189:SPIBUDDY RS14995
gene id: 158189:SPIBUDDY_RS14995
uniprot id: F0RZL7
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS08195
gene id: 158189:SPIBUDDY_RS08195
uniprot id: F0RW78
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS04255
gene id: 158189:SPIBUDDY_RS04255
uniprot id: F0RV24
names: Similarity
messages: Belongs to the aspartokinase family.

158189:SPIBUDDY RS10945
gene id: 158189:SPIBUDDY_RS10945
uniprot id: F0RSS3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

158189:SPIBUDDY RS09670
gene id: 158189:SPIBUDDY_RS09670
uniprot id: F0RWU5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arabinose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of L-arabinose to L-ribulose.

158189:SPIBUDDY RS09830
gene id: 158189:SPIBUDDY_RS09830
uniprot id: F0RWX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

158189:SPIBUDDY RS08070
gene id: 158189:SPIBUDDY_RS08070
uniprot id: F0RW52
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

158189:SPIBUDDY RS08790
gene id: 158189:SPIBUDDY_RS08790
uniprot id: F0RZK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS00625
gene id: 158189:SPIBUDDY_RS00625
uniprot id: F0RXB8
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

158189:SPIBUDDY RS02455
gene id: 158189:SPIBUDDY_RS02455
uniprot id: F0RUG3
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

158189:SPIBUDDY RS06665
gene id: 158189:SPIBUDDY_RS06665
uniprot id: F0RVS0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

158189:SPIBUDDY RS00305
gene id: 158189:SPIBUDDY_RS00305
uniprot id: F0RX56
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

158189:SPIBUDDY RS04225
gene id: 158189:SPIBUDDY_RS04225
uniprot id: F0RV18
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS07510
gene id: 158189:SPIBUDDY_RS07510
uniprot id: F0RW12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

158189:SPIBUDDY RS09215
gene id: 158189:SPIBUDDY_RS09215
uniprot id: F0RWK5
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

158189:SPIBUDDY RS11290
gene id: 158189:SPIBUDDY_RS11290
uniprot id: F0RTG7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

158189:SPIBUDDY RS14140
gene id: 158189:SPIBUDDY_RS14140
uniprot id: F0RS02
names: Function
names: Similarity
messages: Belongs to the bacterial histone-like protein family.
messages: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.

158189:SPIBUDDY RS10295
gene id: 158189:SPIBUDDY_RS10295
uniprot id: F0RTT3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

158189:SPIBUDDY RS01900
gene id: 158189:SPIBUDDY_RS01900
uniprot id: F0RXU0
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

158189:SPIBUDDY RS07315
gene id: 158189:SPIBUDDY_RS07315
uniprot id: F0RZ53
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

158189:SPIBUDDY RS11605
gene id: 158189:SPIBUDDY_RS11605
uniprot id: F0RSJ0
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

158189:SPIBUDDY RS15295
gene id: 158189:SPIBUDDY_RS15295
uniprot id: F0RZS6
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

158189:SPIBUDDY RS15195
gene id: 158189:SPIBUDDY_RS15195
uniprot id: F0RZQ6
names: Similarity
messages: Belongs to the BMP lipoprotein family.

158189:SPIBUDDY RS06370
gene id: 158189:SPIBUDDY_RS06370
uniprot id: F0RYU1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS08965
gene id: 158189:SPIBUDDY_RS08965
uniprot id: F0RWF4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

158189:SPIBUDDY RS06045
gene id: 158189:SPIBUDDY_RS06045
uniprot id: F0RVM7
names: Similarity
messages: Belongs to the citrate synthase family.

158189:SPIBUDDY RS05660
gene id: 158189:SPIBUDDY_RS05660
uniprot id: F0RVF4
names: Similarity
messages: Belongs to the DapB family.

158189:SPIBUDDY RS08845
gene id: 158189:SPIBUDDY_RS08845
uniprot id: F0RWD0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

158189:SPIBUDDY RS08805
gene id: 158189:SPIBUDDY_RS08805
uniprot id: F0RWC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS09850
gene id: 158189:SPIBUDDY_RS09850
uniprot id: F0RWX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

158189:SPIBUDDY RS02070
gene id: 158189:SPIBUDDY_RS02070
uniprot id: F0RXX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS07060
gene id: 158189:SPIBUDDY_RS07060
uniprot id: F0RZ02
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

158189:SPIBUDDY RS06815
gene id: 158189:SPIBUDDY_RS06815
uniprot id: F0RVV0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

158189:SPIBUDDY RS02885
gene id: 158189:SPIBUDDY_RS02885
uniprot id: F0RXY7
names: Similarity
messages: Belongs to the GPI family.

158189:SPIBUDDY RS02635
gene id: 158189:SPIBUDDY_RS02635
uniprot id: F0RUK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

158189:SPIBUDDY RS08430
gene id: 158189:SPIBUDDY_RS08430
uniprot id: F0RZD0
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

158189:SPIBUDDY RS12495
gene id: 158189:SPIBUDDY_RS12495
uniprot id: F0RRM5
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

158189:SPIBUDDY RS07000
gene id: 158189:SPIBUDDY_RS07000
uniprot id: F0RYZ0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

158189:SPIBUDDY RS12825
gene id: 158189:SPIBUDDY_RS12825
uniprot id: F0RSE9
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

158189:SPIBUDDY RS05420
gene id: 158189:SPIBUDDY_RS05420
uniprot id: F0RYQ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

158189:SPIBUDDY RS14450
gene id: 158189:SPIBUDDY_RS14450
uniprot id: F0RS66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

158189:SPIBUDDY RS14605
gene id: 158189:SPIBUDDY_RS14605
uniprot id: F0RS87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

158189:SPIBUDDY RS00310
gene id: 158189:SPIBUDDY_RS00310
uniprot id: F0RX57
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

158189:SPIBUDDY RS04550
gene id: 158189:SPIBUDDY_RS04550
uniprot id: F0RYF8
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS05050
gene id: 158189:SPIBUDDY_RS05050
uniprot id: F0RVA8
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

158189:SPIBUDDY RS06185
gene id: 158189:SPIBUDDY_RS06185
uniprot id: F0RVQ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

158189:SPIBUDDY RS02800
gene id: 158189:SPIBUDDY_RS02800
uniprot id: F0RUN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OadG family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane

158189:SPIBUDDY RS00125
gene id: 158189:SPIBUDDY_RS00125
uniprot id: F0RX21
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.

158189:SPIBUDDY RS06110
gene id: 158189:SPIBUDDY_RS06110
uniprot id: F0RVP0
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS08545
gene id: 158189:SPIBUDDY_RS08545
uniprot id: F0RZF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

158189:SPIBUDDY RS07415
gene id: 158189:SPIBUDDY_RS07415
uniprot id: F0RVZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
messages: Cytoplasm

158189:SPIBUDDY RS07180
gene id: 158189:SPIBUDDY_RS07180
uniprot id: F0RZ26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

158189:SPIBUDDY RS03325
gene id: 158189:SPIBUDDY_RS03325
uniprot id: F0RUR3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

158189:SPIBUDDY RS12295
gene id: 158189:SPIBUDDY_RS12295
uniprot id: F0RRJ1
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS14670
gene id: 158189:SPIBUDDY_RS14670
uniprot id: F0RSA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

158189:SPIBUDDY RS14250
gene id: 158189:SPIBUDDY_RS14250
uniprot id: F0RS24
names: Similarity
messages: Belongs to the TlyA family.

158189:SPIBUDDY RS14130
gene id: 158189:SPIBUDDY_RS14130
uniprot id: F0RS00
names: Similarity
messages: Belongs to the CinA family.

158189:SPIBUDDY RS03200
gene id: 158189:SPIBUDDY_RS03200
uniprot id: F0RY42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

158189:SPIBUDDY RS04090
gene id: 158189:SPIBUDDY_RS04090
uniprot id: F0RUZ1
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

158189:SPIBUDDY RS00035
gene id: 158189:SPIBUDDY_RS00035
uniprot id: F0RX03
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

158189:SPIBUDDY RS14350
gene id: 158189:SPIBUDDY_RS14350
uniprot id: F0RS46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

158189:SPIBUDDY RS06205
gene id: 158189:SPIBUDDY_RS06205
uniprot id: F0RYR5
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

158189:SPIBUDDY RS10560
gene id: 158189:SPIBUDDY_RS10560
uniprot id: F0RTJ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.

158189:SPIBUDDY RS11760
gene id: 158189:SPIBUDDY_RS11760
uniprot id: F0RSN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

158189:SPIBUDDY RS03670
gene id: 158189:SPIBUDDY_RS03670
uniprot id: F0RY60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS12480
gene id: 158189:SPIBUDDY_RS12480
uniprot id: F0RRM2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

158189:SPIBUDDY RS02420
gene id: 158189:SPIBUDDY_RS02420
uniprot id: F0RUF6
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS02035
gene id: 158189:SPIBUDDY_RS02035
uniprot id: F0RXW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS06430
gene id: 158189:SPIBUDDY_RS06430
uniprot id: F0RYV3
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS06600
gene id: 158189:SPIBUDDY_RS06600
uniprot id: F0RVQ8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS14460
gene id: 158189:SPIBUDDY_RS14460
uniprot id: F0RS67
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

158189:SPIBUDDY RS02910
gene id: 158189:SPIBUDDY_RS02910
uniprot id: F0RXZ2
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

158189:SPIBUDDY RS06170
gene id: 158189:SPIBUDDY_RS06170
uniprot id: F0RVQ2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

158189:SPIBUDDY RS10905
gene id: 158189:SPIBUDDY_RS10905
uniprot id: F0RSR5
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

158189:SPIBUDDY RS14020
gene id: 158189:SPIBUDDY_RS14020
uniprot id: F0RRX9
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS09900
gene id: 158189:SPIBUDDY_RS09900
uniprot id: F0RWY8
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.

158189:SPIBUDDY RS01720
gene id: 158189:SPIBUDDY_RS01720
uniprot id: F0RU95
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

158189:SPIBUDDY RS07090
gene id: 158189:SPIBUDDY_RS07090
uniprot id: F0RZ08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

158189:SPIBUDDY RS05615
gene id: 158189:SPIBUDDY_RS05615
uniprot id: F0RVE5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS06305
gene id: 158189:SPIBUDDY_RS06305
uniprot id: F0RYT5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

158189:SPIBUDDY RS02960
gene id: 158189:SPIBUDDY_RS02960
uniprot id: F0RY02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

158189:SPIBUDDY RS05440
gene id: 158189:SPIBUDDY_RS05440
uniprot id: F0RVB4
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

158189:SPIBUDDY RS13885
gene id: 158189:SPIBUDDY_RS13885
uniprot id: F0RRV2
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

158189:SPIBUDDY RS09680
gene id: 158189:SPIBUDDY_RS09680
uniprot id: F0RWU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

158189:SPIBUDDY RS14765
gene id: 158189:SPIBUDDY_RS14765
uniprot id: F0RTM5
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

158189:SPIBUDDY RS12475
gene id: 158189:SPIBUDDY_RS12475
uniprot id: F0RRM1
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS04375
gene id: 158189:SPIBUDDY_RS04375
uniprot id: F0RYC7
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

158189:SPIBUDDY RS05445
gene id: 158189:SPIBUDDY_RS05445
uniprot id: F0RVB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

158189:SPIBUDDY RS03440
gene id: 158189:SPIBUDDY_RS03440
uniprot id: F0RUT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

158189:SPIBUDDY RS04535
gene id: 158189:SPIBUDDY_RS04535
uniprot id: F0RYF5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS15400
gene id: 158189:SPIBUDDY_RS15400
uniprot id: F0RZU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

158189:SPIBUDDY RS00095
gene id: 158189:SPIBUDDY_RS00095
uniprot id: F0RX15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

158189:SPIBUDDY RS04380
gene id: 158189:SPIBUDDY_RS04380
uniprot id: F0RYC8
names: Similarity
messages: Belongs to the UPF0597 family.

158189:SPIBUDDY RS11325
gene id: 158189:SPIBUDDY_RS11325
uniprot id: F0RTX0
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS01905
gene id: 158189:SPIBUDDY_RS01905
uniprot id: F0RXU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

158189:SPIBUDDY RS03320
gene id: 158189:SPIBUDDY_RS03320
uniprot id: F0RUR2
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

158189:SPIBUDDY RS14375
gene id: 158189:SPIBUDDY_RS14375
uniprot id: F0RS51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

158189:SPIBUDDY RS12040
gene id: 158189:SPIBUDDY_RS12040
uniprot id: F0RRD7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

158189:SPIBUDDY RS05650
gene id: 158189:SPIBUDDY_RS05650
uniprot id: F0RVF2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

158189:SPIBUDDY RS00580
gene id: 158189:SPIBUDDY_RS00580
uniprot id: F0RXA9
names: Similarity
messages: Belongs to the glutamine synthetase family.

158189:SPIBUDDY RS06125
gene id: 158189:SPIBUDDY_RS06125
uniprot id: F0RVP3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

158189:SPIBUDDY RS05045
gene id: 158189:SPIBUDDY_RS05045
uniprot id: F0RVA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS00855
gene id: 158189:SPIBUDDY_RS00855
uniprot id: F0RXG3
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS06825
gene id: 158189:SPIBUDDY_RS06825
uniprot id: F0RVV2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

158189:SPIBUDDY RS05600
gene id: 158189:SPIBUDDY_RS05600
uniprot id: F0RVE2
names: Similarity
messages: Belongs to the type IA topoisomerase family.

158189:SPIBUDDY RS04475
gene id: 158189:SPIBUDDY_RS04475
uniprot id: F0RYE5
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

158189:SPIBUDDY RS13810
gene id: 158189:SPIBUDDY_RS13810
uniprot id: F0RRT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS15330
gene id: 158189:SPIBUDDY_RS15330
uniprot id: F0RZT3
names: Similarity
messages: Belongs to the thymidine kinase family.

158189:SPIBUDDY RS05665
gene id: 158189:SPIBUDDY_RS05665
uniprot id: F0RVF5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

158189:SPIBUDDY RS15475
gene id: 158189:SPIBUDDY_RS15475
uniprot id: F0RZV6
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

158189:SPIBUDDY RS14320
gene id: 158189:SPIBUDDY_RS14320
uniprot id: F0RS39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

158189:SPIBUDDY RS16190
gene id: 158189:SPIBUDDY_RS16190
uniprot id: F0RWZ4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

158189:SPIBUDDY RS12770
gene id: 158189:SPIBUDDY_RS12770
uniprot id: F0RSD8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

158189:SPIBUDDY RS10755
gene id: 158189:SPIBUDDY_RS10755
uniprot id: F0RSY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

158189:SPIBUDDY RS07155
gene id: 158189:SPIBUDDY_RS07155
uniprot id: F0RZ21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

158189:SPIBUDDY RS08610
gene id: 158189:SPIBUDDY_RS08610
uniprot id: F0RZG7
names: Similarity
messages: Belongs to the serpin family.

158189:SPIBUDDY RS01200
gene id: 158189:SPIBUDDY_RS01200
uniprot id: F0RXN0
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

158189:SPIBUDDY RS07730
gene id: 158189:SPIBUDDY_RS07730
uniprot id: F0RZ60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS14370
gene id: 158189:SPIBUDDY_RS14370
uniprot id: F0RS50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

158189:SPIBUDDY RS02030
gene id: 158189:SPIBUDDY_RS02030
uniprot id: F0RXW4
names: Function
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

158189:SPIBUDDY RS07435
gene id: 158189:SPIBUDDY_RS07435
uniprot id: F0RVZ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

158189:SPIBUDDY RS02905
gene id: 158189:SPIBUDDY_RS02905
uniprot id: F0RXZ1
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

158189:SPIBUDDY RS07635
gene id: 158189:SPIBUDDY_RS07635
uniprot id: F0RW36
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Cytoplasm
messages: Homodimer.

158189:SPIBUDDY RS11465
gene id: 158189:SPIBUDDY_RS11465
uniprot id: F0RTZ8
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS06215
gene id: 158189:SPIBUDDY_RS06215
uniprot id: F0RYR7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

158189:SPIBUDDY RS14100
gene id: 158189:SPIBUDDY_RS14100
uniprot id: F0RRZ4
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

158189:SPIBUDDY RS00535
gene id: 158189:SPIBUDDY_RS00535
uniprot id: F0RXA1
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

158189:SPIBUDDY RS05240
gene id: 158189:SPIBUDDY_RS05240
uniprot id: F0RYM3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

158189:SPIBUDDY RS10750
gene id: 158189:SPIBUDDY_RS10750
uniprot id: F0RSY8
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

158189:SPIBUDDY RS02275
gene id: 158189:SPIBUDDY_RS02275
uniprot id: F0RUC7
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS04790
gene id: 158189:SPIBUDDY_RS04790
uniprot id: F0RV56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

158189:SPIBUDDY RS08270
gene id: 158189:SPIBUDDY_RS08270
uniprot id: F0RW93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS07495
gene id: 158189:SPIBUDDY_RS07495
uniprot id: F0RW09
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

158189:SPIBUDDY RS05800
gene id: 158189:SPIBUDDY_RS05800
uniprot id: F0RVI1
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

158189:SPIBUDDY RS10380
gene id: 158189:SPIBUDDY_RS10380
uniprot id: F0RU05
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

158189:SPIBUDDY RS04595
gene id: 158189:SPIBUDDY_RS04595
uniprot id: F0RYG8
names: Similarity
messages: Belongs to the TrpR family.

158189:SPIBUDDY RS02530
gene id: 158189:SPIBUDDY_RS02530
uniprot id: F0RUH8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS10580
gene id: 158189:SPIBUDDY_RS10580
uniprot id: F0RTJ5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

158189:SPIBUDDY RS14325
gene id: 158189:SPIBUDDY_RS14325
uniprot id: F0RS41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

158189:SPIBUDDY RS04685
gene id: 158189:SPIBUDDY_RS04685
uniprot id: F0RYI5
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS14305
gene id: 158189:SPIBUDDY_RS14305
uniprot id: F0RS36
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

158189:SPIBUDDY RS12720
gene id: 158189:SPIBUDDY_RS12720
uniprot id: F0RSC9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

158189:SPIBUDDY RS10695
gene id: 158189:SPIBUDDY_RS10695
uniprot id: F0RSX8
names: Similarity
messages: Belongs to the leucine-binding protein family.

158189:SPIBUDDY RS06805
gene id: 158189:SPIBUDDY_RS06805
uniprot id: F0RVU8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

158189:SPIBUDDY RS00700
gene id: 158189:SPIBUDDY_RS00700
uniprot id: F0RXD2
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

158189:SPIBUDDY RS06780
gene id: 158189:SPIBUDDY_RS06780
uniprot id: F0RVU3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

158189:SPIBUDDY RS07170
gene id: 158189:SPIBUDDY_RS07170
uniprot id: F0RZ24
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

158189:SPIBUDDY RS07845
gene id: 158189:SPIBUDDY_RS07845
uniprot id: F0RZ83
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS07175
gene id: 158189:SPIBUDDY_RS07175
uniprot id: F0RZ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

158189:SPIBUDDY RS04340
gene id: 158189:SPIBUDDY_RS04340
uniprot id: F0RV40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the encapsulin family. Family 1 subfamily.
messages: Encapsulin nanocompartment

158189:SPIBUDDY RS03700
gene id: 158189:SPIBUDDY_RS03700
uniprot id: F0RY66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS10055
gene id: 158189:SPIBUDDY_RS10055
uniprot id: F0RTR0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

158189:SPIBUDDY RS00670
gene id: 158189:SPIBUDDY_RS00670
uniprot id: F0RXC7
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

158189:SPIBUDDY RS10685
gene id: 158189:SPIBUDDY_RS10685
uniprot id: F0RSN6
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS06150
gene id: 158189:SPIBUDDY_RS06150
uniprot id: F0RVP8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

158189:SPIBUDDY RS12505
gene id: 158189:SPIBUDDY_RS12505
uniprot id: F0RRM7
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

158189:SPIBUDDY RS11630
gene id: 158189:SPIBUDDY_RS11630
uniprot id: F0RSJ5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS14310
gene id: 158189:SPIBUDDY_RS14310
uniprot id: F0RS37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

158189:SPIBUDDY RS13370
gene id: 158189:SPIBUDDY_RS13370
uniprot id: F0RT64
names: Similarity
messages: Belongs to the alkaline phosphatase family.

158189:SPIBUDDY RS06425
gene id: 158189:SPIBUDDY_RS06425
uniprot id: F0RYV2
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS08010
gene id: 158189:SPIBUDDY_RS08010
uniprot id: F0RZB6
names: Similarity
messages: Belongs to the group II decarboxylase family.

158189:SPIBUDDY RS14270
gene id: 158189:SPIBUDDY_RS14270
uniprot id: F0RS28
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

158189:SPIBUDDY RS08735
gene id: 158189:SPIBUDDY_RS08735
uniprot id: F0RZJ0
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

158189:SPIBUDDY RS15620
gene id: 158189:SPIBUDDY_RS15620
uniprot id: F0RUU1
names: Similarity
messages: Belongs to the ice-binding protein family.

158189:SPIBUDDY RS00200
gene id: 158189:SPIBUDDY_RS00200
uniprot id: F0RX35
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

158189:SPIBUDDY RS00990
gene id: 158189:SPIBUDDY_RS00990
uniprot id: F0RXI9
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

158189:SPIBUDDY RS14520
gene id: 158189:SPIBUDDY_RS14520
uniprot id: F0RS79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

158189:SPIBUDDY RS11490
gene id: 158189:SPIBUDDY_RS11490
uniprot id: F0RSG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS13965
gene id: 158189:SPIBUDDY_RS13965
uniprot id: F0RRW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS08370
gene id: 158189:SPIBUDDY_RS08370
uniprot id: F0RWB3
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

158189:SPIBUDDY RS12430
gene id: 158189:SPIBUDDY_RS12430
uniprot id: F0RRL2
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. Sucrose phosphorylase subfamily.

158189:SPIBUDDY RS09740
gene id: 158189:SPIBUDDY_RS09740
uniprot id: F0RWV9
names: Similarity
messages: Belongs to the peptidase S1C family.

158189:SPIBUDDY RS03340
gene id: 158189:SPIBUDDY_RS03340
uniprot id: F0RUR6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: In the N-terminal section; belongs to the histidinol-phosphatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS15595
gene id: 158189:SPIBUDDY_RS15595
uniprot id: F0RY00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

158189:SPIBUDDY RS14395
gene id: 158189:SPIBUDDY_RS14395
uniprot id: F0RS55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

158189:SPIBUDDY RS13305
gene id: 158189:SPIBUDDY_RS13305
uniprot id: F0RT86
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

158189:SPIBUDDY RS09960
gene id: 158189:SPIBUDDY_RS09960
uniprot id: F0RZX0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

158189:SPIBUDDY RS02240
gene id: 158189:SPIBUDDY_RS02240
uniprot id: F0RUC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

158189:SPIBUDDY RS00235
gene id: 158189:SPIBUDDY_RS00235
uniprot id: F0RX42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

158189:SPIBUDDY RS02510
gene id: 158189:SPIBUDDY_RS02510
uniprot id: F0RUH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

158189:SPIBUDDY RS01595
gene id: 158189:SPIBUDDY_RS01595
uniprot id: F0RU71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS12450
gene id: 158189:SPIBUDDY_RS12450
uniprot id: F0RRL6
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

158189:SPIBUDDY RS00920
gene id: 158189:SPIBUDDY_RS00920
uniprot id: F0RXH5
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.

158189:SPIBUDDY RS06505
gene id: 158189:SPIBUDDY_RS06505
uniprot id: F0RYW8
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS07770
gene id: 158189:SPIBUDDY_RS07770
uniprot id: F0RZ68
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

158189:SPIBUDDY RS01130
gene id: 158189:SPIBUDDY_RS01130
uniprot id: F0RXL6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS05565
gene id: 158189:SPIBUDDY_RS05565
uniprot id: F0RVD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

158189:SPIBUDDY RS04095
gene id: 158189:SPIBUDDY_RS04095
uniprot id: F0RUZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

158189:SPIBUDDY RS11185
gene id: 158189:SPIBUDDY_RS11185
uniprot id: F0RSW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS06785
gene id: 158189:SPIBUDDY_RS06785
uniprot id: F0RVU4
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

158189:SPIBUDDY RS06475
gene id: 158189:SPIBUDDY_RS06475
uniprot id: F0RYW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

158189:SPIBUDDY RS01735
gene id: 158189:SPIBUDDY_RS01735
uniprot id: F0RXQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS14430
gene id: 158189:SPIBUDDY_RS14430
uniprot id: F0RS62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

158189:SPIBUDDY RS03515
gene id: 158189:SPIBUDDY_RS03515
uniprot id: F0RUV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS07065
gene id: 158189:SPIBUDDY_RS07065
uniprot id: F0RZ03
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS12365
gene id: 158189:SPIBUDDY_RS12365
uniprot id: F0RRJ8
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS04205
gene id: 158189:SPIBUDDY_RS04205
uniprot id: F0RV14
names: Similarity
messages: Belongs to the DEAD box helicase family.

158189:SPIBUDDY RS13490
gene id: 158189:SPIBUDDY_RS13490
uniprot id: F0RT34
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

158189:SPIBUDDY RS03100
gene id: 158189:SPIBUDDY_RS03100
uniprot id: F0RY24
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

158189:SPIBUDDY RS06605
gene id: 158189:SPIBUDDY_RS06605
uniprot id: F0RVQ9
names: Similarity
messages: Belongs to the peptidase M29 family.

158189:SPIBUDDY RS07645
gene id: 158189:SPIBUDDY_RS07645
uniprot id: F0RW38
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

158189:SPIBUDDY RS06910
gene id: 158189:SPIBUDDY_RS06910
uniprot id: F0RVW9
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

158189:SPIBUDDY RS09175
gene id: 158189:SPIBUDDY_RS09175
uniprot id: F0RWJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

158189:SPIBUDDY RS02270
gene id: 158189:SPIBUDDY_RS02270
uniprot id: F0RUC6
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS00275
gene id: 158189:SPIBUDDY_RS00275
uniprot id: F0RX50
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS15425
gene id: 158189:SPIBUDDY_RS15425
uniprot id: F0RZU7
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

158189:SPIBUDDY RS04850
gene id: 158189:SPIBUDDY_RS04850
uniprot id: F0RV68
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS14490
gene id: 158189:SPIBUDDY_RS14490
uniprot id: F0RS72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

158189:SPIBUDDY RS07705
gene id: 158189:SPIBUDDY_RS07705
uniprot id: F0RW50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS08415
gene id: 158189:SPIBUDDY_RS08415
uniprot id: F0RWC2
names: Similarity
messages: Belongs to the DapA family.

158189:SPIBUDDY RS14830
gene id: 158189:SPIBUDDY_RS14830
uniprot id: F0RTN8
names: Similarity
messages: Belongs to the peptidase S16 family.

158189:SPIBUDDY RS14385
gene id: 158189:SPIBUDDY_RS14385
uniprot id: F0RS53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

158189:SPIBUDDY RS07430
gene id: 158189:SPIBUDDY_RS07430
uniprot id: F0RVZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

158189:SPIBUDDY RS14145
gene id: 158189:SPIBUDDY_RS14145
uniprot id: F0RS03
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

158189:SPIBUDDY RS14135
gene id: 158189:SPIBUDDY_RS14135
uniprot id: F0RS01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

158189:SPIBUDDY RS11480
gene id: 158189:SPIBUDDY_RS11480
uniprot id: F0RSG6
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

158189:SPIBUDDY RS10275
gene id: 158189:SPIBUDDY_RS10275
uniprot id: F0RTS9
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS14010
gene id: 158189:SPIBUDDY_RS14010
uniprot id: F0RRX7
names: Similarity
messages: Belongs to the band 7/mec-2 family.

158189:SPIBUDDY RS07915
gene id: 158189:SPIBUDDY_RS07915
uniprot id: F0RZ97
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS04425
gene id: 158189:SPIBUDDY_RS04425
uniprot id: F0RYD5
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

158189:SPIBUDDY RS03275
gene id: 158189:SPIBUDDY_RS03275
uniprot id: F0RUQ3
names: Similarity
messages: Belongs to the UPF0251 family.

158189:SPIBUDDY RS02375
gene id: 158189:SPIBUDDY_RS02375
uniprot id: F0RUE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

158189:SPIBUDDY RS13710
gene id: 158189:SPIBUDDY_RS13710
uniprot id: F0RSB3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

158189:SPIBUDDY RS03300
gene id: 158189:SPIBUDDY_RS03300
uniprot id: F0RUQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

158189:SPIBUDDY RS04065
gene id: 158189:SPIBUDDY_RS04065
uniprot id: F0RUY6
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.

158189:SPIBUDDY RS05900
gene id: 158189:SPIBUDDY_RS05900
uniprot id: F0RVJ8
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS11695
gene id: 158189:SPIBUDDY_RS11695
uniprot id: F0RSK9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.

158189:SPIBUDDY RS09125
gene id: 158189:SPIBUDDY_RS09125
uniprot id: F0RWI7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS14120
gene id: 158189:SPIBUDDY_RS14120
uniprot id: F0RRZ8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

158189:SPIBUDDY RS02675
gene id: 158189:SPIBUDDY_RS02675
uniprot id: F0RUK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS10915
gene id: 158189:SPIBUDDY_RS10915
uniprot id: F0RSR7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

158189:SPIBUDDY RS01180
gene id: 158189:SPIBUDDY_RS01180
uniprot id: F0RXM6
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

158189:SPIBUDDY RS14715
gene id: 158189:SPIBUDDY_RS14715
uniprot id: F0RTL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

158189:SPIBUDDY RS02450
gene id: 158189:SPIBUDDY_RS02450
uniprot id: F0RUG2
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

158189:SPIBUDDY RS14750
gene id: 158189:SPIBUDDY_RS14750
uniprot id: F0RTM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer.

158189:SPIBUDDY RS00930
gene id: 158189:SPIBUDDY_RS00930
uniprot id: F0RXH7
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

158189:SPIBUDDY RS15320
gene id: 158189:SPIBUDDY_RS15320
uniprot id: F0RZT1
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

158189:SPIBUDDY RS03785
gene id: 158189:SPIBUDDY_RS03785
uniprot id: F0RY83
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

158189:SPIBUDDY RS08465
gene id: 158189:SPIBUDDY_RS08465
uniprot id: F0RZD8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

158189:SPIBUDDY RS03910
gene id: 158189:SPIBUDDY_RS03910
uniprot id: F0RYA8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

158189:SPIBUDDY RS00925
gene id: 158189:SPIBUDDY_RS00925
uniprot id: F0RXH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS06130
gene id: 158189:SPIBUDDY_RS06130
uniprot id: F0RVP4
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

158189:SPIBUDDY RS03720
gene id: 158189:SPIBUDDY_RS03720
uniprot id: F0RY70
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS01290
gene id: 158189:SPIBUDDY_RS01290
uniprot id: F0RXP7
names: Similarity
messages: Belongs to the archaeal-type GPI family.

158189:SPIBUDDY RS10955
gene id: 158189:SPIBUDDY_RS10955
uniprot id: F0RSS5
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

158189:SPIBUDDY RS10830
gene id: 158189:SPIBUDDY_RS10830
uniprot id: F0RT05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS12235
gene id: 158189:SPIBUDDY_RS12235
uniprot id: F0RRH9
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS07230
gene id: 158189:SPIBUDDY_RS07230
uniprot id: F0RZ36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

158189:SPIBUDDY RS06675
gene id: 158189:SPIBUDDY_RS06675
uniprot id: F0RVS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

158189:SPIBUDDY RS03015
gene id: 158189:SPIBUDDY_RS03015
uniprot id: F0RY09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS13035
gene id: 158189:SPIBUDDY_RS13035
uniprot id: F0RT89
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

158189:SPIBUDDY RS14260
gene id: 158189:SPIBUDDY_RS14260
uniprot id: F0RS26
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

158189:SPIBUDDY RS14075
gene id: 158189:SPIBUDDY_RS14075
uniprot id: F0RRY9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

158189:SPIBUDDY RS07305
gene id: 158189:SPIBUDDY_RS07305
uniprot id: F0RZ51
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

158189:SPIBUDDY RS15250
gene id: 158189:SPIBUDDY_RS15250
uniprot id: F0RZR7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

158189:SPIBUDDY RS02140
gene id: 158189:SPIBUDDY_RS02140
uniprot id: F0RUA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS11805
gene id: 158189:SPIBUDDY_RS11805
uniprot id: F0RSM8
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

158189:SPIBUDDY RS06245
gene id: 158189:SPIBUDDY_RS06245
uniprot id: F0RYS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

158189:SPIBUDDY RS09825
gene id: 158189:SPIBUDDY_RS09825
uniprot id: F0RWX4
names: Similarity
messages: Belongs to the aldose epimerase family.

158189:SPIBUDDY RS06560
gene id: 158189:SPIBUDDY_RS06560
uniprot id: F0RYX9
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

158189:SPIBUDDY RS14215
gene id: 158189:SPIBUDDY_RS14215
uniprot id: F0RS17
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

158189:SPIBUDDY RS05330
gene id: 158189:SPIBUDDY_RS05330
uniprot id: F0RYP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

158189:SPIBUDDY RS02100
gene id: 158189:SPIBUDDY_RS02100
uniprot id: F0RXX8
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

158189:SPIBUDDY RS10300
gene id: 158189:SPIBUDDY_RS10300
uniprot id: F0RTT4
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

158189:SPIBUDDY RS11575
gene id: 158189:SPIBUDDY_RS11575
uniprot id: F0RSI5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

158189:SPIBUDDY RS00055
gene id: 158189:SPIBUDDY_RS00055
uniprot id: F0RX07
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

158189:SPIBUDDY RS04750
gene id: 158189:SPIBUDDY_RS04750
uniprot id: F0RV48
names: Similarity
messages: Belongs to the DtxR/MntR family.

158189:SPIBUDDY RS03545
gene id: 158189:SPIBUDDY_RS03545
uniprot id: F0RUV6
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS11065
gene id: 158189:SPIBUDDY_RS11065
uniprot id: F0RSU6
names: Similarity
messages: Belongs to the thioredoxin family.

158189:SPIBUDDY RS01935
gene id: 158189:SPIBUDDY_RS01935
uniprot id: F0RXU7
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

158189:SPIBUDDY RS08945
gene id: 158189:SPIBUDDY_RS08945
uniprot id: F0RWF0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

158189:SPIBUDDY RS06630
gene id: 158189:SPIBUDDY_RS06630
uniprot id: F0RVR3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

158189:SPIBUDDY RS07450
gene id: 158189:SPIBUDDY_RS07450
uniprot id: F0RW01
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

158189:SPIBUDDY RS04820
gene id: 158189:SPIBUDDY_RS04820
uniprot id: F0RV62
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

158189:SPIBUDDY RS06800
gene id: 158189:SPIBUDDY_RS06800
uniprot id: F0RVU7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

158189:SPIBUDDY RS14945
gene id: 158189:SPIBUDDY_RS14945
uniprot id: F0RZK7
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

158189:SPIBUDDY RS00620
gene id: 158189:SPIBUDDY_RS00620
uniprot id: F0RXB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

158189:SPIBUDDY RS14900
gene id: 158189:SPIBUDDY_RS14900
uniprot id: F0RTQ1
names: Similarity
messages: Belongs to the CarB family.

158189:SPIBUDDY RS00960
gene id: 158189:SPIBUDDY_RS00960
uniprot id: F0RXI3
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

158189:SPIBUDDY RS11880
gene id: 158189:SPIBUDDY_RS11880
uniprot id: F0RSQ4
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.

158189:SPIBUDDY RS03675
gene id: 158189:SPIBUDDY_RS03675
uniprot id: F0RY61
names: Similarity
messages: Belongs to the glycosyl hydrolase 51 family.

158189:SPIBUDDY RS08695
gene id: 158189:SPIBUDDY_RS08695
uniprot id: F0RZI3
names: Similarity
messages: Belongs to the threonine synthase family.

158189:SPIBUDDY RS03870
gene id: 158189:SPIBUDDY_RS03870
uniprot id: F0RYA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

158189:SPIBUDDY RS02705
gene id: 158189:SPIBUDDY_RS02705
uniprot id: F0RUL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

158189:SPIBUDDY RS08115
gene id: 158189:SPIBUDDY_RS08115
uniprot id: F0RW61
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

158189:SPIBUDDY RS14125
gene id: 158189:SPIBUDDY_RS14125
uniprot id: F0RRZ9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS04275
gene id: 158189:SPIBUDDY_RS04275
uniprot id: F0RV28
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS10990
gene id: 158189:SPIBUDDY_RS10990
uniprot id: F0RST2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS05710
gene id: 158189:SPIBUDDY_RS05710
uniprot id: F0RVG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

158189:SPIBUDDY RS07700
gene id: 158189:SPIBUDDY_RS07700
uniprot id: F0RW49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS15450
gene id: 158189:SPIBUDDY_RS15450
uniprot id: F0RZV1
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

158189:SPIBUDDY RS16185
gene id: 158189:SPIBUDDY_RS16185
uniprot id: F0RWZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

158189:SPIBUDDY RS05350
gene id: 158189:SPIBUDDY_RS05350
uniprot id: F0RYP6
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

158189:SPIBUDDY RS13495
gene id: 158189:SPIBUDDY_RS13495
uniprot id: F0RT35
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS00490
gene id: 158189:SPIBUDDY_RS00490
uniprot id: F0RX93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS13460
gene id: 158189:SPIBUDDY_RS13460
uniprot id: F0RT30
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

158189:SPIBUDDY RS01830
gene id: 158189:SPIBUDDY_RS01830
uniprot id: F0RXS6
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

158189:SPIBUDDY RS14400
gene id: 158189:SPIBUDDY_RS14400
uniprot id: F0RS56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

158189:SPIBUDDY RS11530
gene id: 158189:SPIBUDDY_RS11530
uniprot id: F0RSH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS01285
gene id: 158189:SPIBUDDY_RS01285
uniprot id: F0RXP6
names: Similarity
messages: Belongs to the polysaccharide synthase family.

158189:SPIBUDDY RS03070
gene id: 158189:SPIBUDDY_RS03070
uniprot id: F0RY20
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS06390
gene id: 158189:SPIBUDDY_RS06390
uniprot id: F0RYU5
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

158189:SPIBUDDY RS06635
gene id: 158189:SPIBUDDY_RS06635
uniprot id: F0RVR4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

158189:SPIBUDDY RS13410
gene id: 158189:SPIBUDDY_RS13410
uniprot id: F0RT18
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

158189:SPIBUDDY RS06495
gene id: 158189:SPIBUDDY_RS06495
uniprot id: F0RYW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

158189:SPIBUDDY RS04485
gene id: 158189:SPIBUDDY_RS04485
uniprot id: F0RYE7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

158189:SPIBUDDY RS03695
gene id: 158189:SPIBUDDY_RS03695
uniprot id: F0RY65
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS04110
gene id: 158189:SPIBUDDY_RS04110
uniprot id: F0RUZ5
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS12725
gene id: 158189:SPIBUDDY_RS12725
uniprot id: F0RSD0
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

158189:SPIBUDDY RS13095
gene id: 158189:SPIBUDDY_RS13095
uniprot id: F0RTA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS12360
gene id: 158189:SPIBUDDY_RS12360
uniprot id: F0RRJ7
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS09710
gene id: 158189:SPIBUDDY_RS09710
uniprot id: F0RWV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS13235
gene id: 158189:SPIBUDDY_RS13235
uniprot id: F0RTE7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

158189:SPIBUDDY RS14650
gene id: 158189:SPIBUDDY_RS14650
uniprot id: F0RS96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

158189:SPIBUDDY RS08325
gene id: 158189:SPIBUDDY_RS08325
uniprot id: F0RWA4
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

158189:SPIBUDDY RS12255
gene id: 158189:SPIBUDDY_RS12255
uniprot id: F0RRI3
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

158189:SPIBUDDY RS02355
gene id: 158189:SPIBUDDY_RS02355
uniprot id: F0RUE3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

158189:SPIBUDDY RS08250
gene id: 158189:SPIBUDDY_RS08250
uniprot id: F0RW89
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS14080
gene id: 158189:SPIBUDDY_RS14080
uniprot id: F0RRZ0
names: Similarity
messages: Belongs to the AOR/FOR family.

158189:SPIBUDDY RS15245
gene id: 158189:SPIBUDDY_RS15245
uniprot id: F0RZR6
names: Similarity
messages: Belongs to the UxaA family.

158189:SPIBUDDY RS03245
gene id: 158189:SPIBUDDY_RS03245
uniprot id: F0RUP7
names: Similarity
messages: Belongs to the ABC transporter superfamily.

158189:SPIBUDDY RS02170
gene id: 158189:SPIBUDDY_RS02170
uniprot id: F0RUA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS06195
gene id: 158189:SPIBUDDY_RS06195
uniprot id: F0RYR3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS10045
gene id: 158189:SPIBUDDY_RS10045
uniprot id: F0RTQ8
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

158189:SPIBUDDY RS06685
gene id: 158189:SPIBUDDY_RS06685
uniprot id: F0RVS4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

158189:SPIBUDDY RS09040
gene id: 158189:SPIBUDDY_RS09040
uniprot id: F0RWG9
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

158189:SPIBUDDY RS04860
gene id: 158189:SPIBUDDY_RS04860
uniprot id: F0RV70
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

158189:SPIBUDDY RS00140
gene id: 158189:SPIBUDDY_RS00140
uniprot id: F0RX24
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS10305
gene id: 158189:SPIBUDDY_RS10305
uniprot id: F0RTT5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS00030
gene id: 158189:SPIBUDDY_RS00030
uniprot id: F0RX02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

158189:SPIBUDDY RS04250
gene id: 158189:SPIBUDDY_RS04250
uniprot id: F0RV23
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS11115
gene id: 158189:SPIBUDDY_RS11115
uniprot id: F0RSV6
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS03630
gene id: 158189:SPIBUDDY_RS03630
uniprot id: F0RY52
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

158189:SPIBUDDY RS00665
gene id: 158189:SPIBUDDY_RS00665
uniprot id: F0RXC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS01925
gene id: 158189:SPIBUDDY_RS01925
uniprot id: F0RXU5
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

158189:SPIBUDDY RS14905
gene id: 158189:SPIBUDDY_RS14905
uniprot id: F0RTQ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS08825
gene id: 158189:SPIBUDDY_RS08825
uniprot id: F0RWC8
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

158189:SPIBUDDY RS12385
gene id: 158189:SPIBUDDY_RS12385
uniprot id: F0RRK2
names: Similarity
messages: Belongs to the DEAD box helicase family.

158189:SPIBUDDY RS07520
gene id: 158189:SPIBUDDY_RS07520
uniprot id: F0RW14
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

158189:SPIBUDDY RS02175
gene id: 158189:SPIBUDDY_RS02175
uniprot id: F0RUA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS01165
gene id: 158189:SPIBUDDY_RS01165
uniprot id: F0RXM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS14295
gene id: 158189:SPIBUDDY_RS14295
uniprot id: F0RS34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

158189:SPIBUDDY RS09845
gene id: 158189:SPIBUDDY_RS09845
uniprot id: F0RWX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

158189:SPIBUDDY RS11800
gene id: 158189:SPIBUDDY_RS11800
uniprot id: F0RSM7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS15480
gene id: 158189:SPIBUDDY_RS15480
uniprot id: F0RZV7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

158189:SPIBUDDY RS06950
gene id: 158189:SPIBUDDY_RS06950
uniprot id: F0RVX5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

158189:SPIBUDDY RS07820
gene id: 158189:SPIBUDDY_RS07820
uniprot id: F0RZ78
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

158189:SPIBUDDY RS00825
gene id: 158189:SPIBUDDY_RS00825
uniprot id: F0RXF7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

158189:SPIBUDDY RS04060
gene id: 158189:SPIBUDDY_RS04060
uniprot id: F0RUY5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

158189:SPIBUDDY RS09220
gene id: 158189:SPIBUDDY_RS09220
uniprot id: F0RWK6
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.

158189:SPIBUDDY RS03345
gene id: 158189:SPIBUDDY_RS03345
uniprot id: F0RUR7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

158189:SPIBUDDY RS11265
gene id: 158189:SPIBUDDY_RS11265
uniprot id: F0RTG2
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS06700
gene id: 158189:SPIBUDDY_RS06700
uniprot id: F0RVS7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

158189:SPIBUDDY RS15185
gene id: 158189:SPIBUDDY_RS15185
uniprot id: F0RZQ4
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS00120
gene id: 158189:SPIBUDDY_RS00120
uniprot id: F0RX20
names: Similarity
messages: Belongs to the peptidase M24B family.

158189:SPIBUDDY RS03645
gene id: 158189:SPIBUDDY_RS03645
uniprot id: F0RY55
names: Similarity
messages: Belongs to the DapA family.

158189:SPIBUDDY RS06140
gene id: 158189:SPIBUDDY_RS06140
uniprot id: F0RVP6
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS03315
gene id: 158189:SPIBUDDY_RS03315
uniprot id: F0RUR1
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

158189:SPIBUDDY RS02120
gene id: 158189:SPIBUDDY_RS02120
uniprot id: F0RXY2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates zinc uptake. May also transport other divalent cations.
messages: Membrane

158189:SPIBUDDY RS07210
gene id: 158189:SPIBUDDY_RS07210
uniprot id: F0RZ32
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

158189:SPIBUDDY RS00545
gene id: 158189:SPIBUDDY_RS00545
uniprot id: F0RXA3
names: Similarity
messages: Belongs to the glutamine synthetase family.

158189:SPIBUDDY RS05795
gene id: 158189:SPIBUDDY_RS05795
uniprot id: F0RVI0
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

158189:SPIBUDDY RS15075
gene id: 158189:SPIBUDDY_RS15075
uniprot id: F0RZN3
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

158189:SPIBUDDY RS08400
gene id: 158189:SPIBUDDY_RS08400
uniprot id: F0RWB9
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS12275
gene id: 158189:SPIBUDDY_RS12275
uniprot id: F0RRI7
names: Similarity
messages: Belongs to the FGGY kinase family.

158189:SPIBUDDY RS11170
gene id: 158189:SPIBUDDY_RS11170
uniprot id: F0RSW5
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

158189:SPIBUDDY RS13905
gene id: 158189:SPIBUDDY_RS13905
uniprot id: F0RRV6
names: Similarity
messages: Belongs to the creatininase superfamily.

158189:SPIBUDDY RS04670
gene id: 158189:SPIBUDDY_RS04670
uniprot id: F0RYI2
names: Similarity
messages: Belongs to the BMP lipoprotein family.

158189:SPIBUDDY RS01100
gene id: 158189:SPIBUDDY_RS01100
uniprot id: F0RXL1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

158189:SPIBUDDY RS11485
gene id: 158189:SPIBUDDY_RS11485
uniprot id: F0RSG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS14835
gene id: 158189:SPIBUDDY_RS14835
uniprot id: F0RTN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

158189:SPIBUDDY RS06715
gene id: 158189:SPIBUDDY_RS06715
uniprot id: F0RVT0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

158189:SPIBUDDY RS10650
gene id: 158189:SPIBUDDY_RS10650
uniprot id: F0RTK8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS08550
gene id: 158189:SPIBUDDY_RS08550
uniprot id: F0RZF5
names: Function
names: Similarity
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.

158189:SPIBUDDY RS07385
gene id: 158189:SPIBUDDY_RS07385
uniprot id: F0RVY8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

158189:SPIBUDDY RS04005
gene id: 158189:SPIBUDDY_RS04005
uniprot id: F0RUX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmKL family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.

158189:SPIBUDDY RS01035
gene id: 158189:SPIBUDDY_RS01035
uniprot id: F0RXJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS06410
gene id: 158189:SPIBUDDY_RS06410
uniprot id: F0RYU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

158189:SPIBUDDY RS07215
gene id: 158189:SPIBUDDY_RS07215
uniprot id: F0RZ33
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS02540
gene id: 158189:SPIBUDDY_RS02540
uniprot id: F0RUI1
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

158189:SPIBUDDY RS00440
gene id: 158189:SPIBUDDY_RS00440
uniprot id: F0RX83
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS15165
gene id: 158189:SPIBUDDY_RS15165
uniprot id: F0RZQ0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

158189:SPIBUDDY RS12270
gene id: 158189:SPIBUDDY_RS12270
uniprot id: F0RRI6
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

158189:SPIBUDDY RS05995
gene id: 158189:SPIBUDDY_RS05995
uniprot id: F0RVL7
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS03455
gene id: 158189:SPIBUDDY_RS03455
uniprot id: F0RUT9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS10535
gene id: 158189:SPIBUDDY_RS10535
uniprot id: F0RTF5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

158189:SPIBUDDY RS13320
gene id: 158189:SPIBUDDY_RS13320
uniprot id: F0RT97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS06445
gene id: 158189:SPIBUDDY_RS06445
uniprot id: F0RYV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

158189:SPIBUDDY RS03395
gene id: 158189:SPIBUDDY_RS03395
uniprot id: F0RUS7
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

158189:SPIBUDDY RS02345
gene id: 158189:SPIBUDDY_RS02345
uniprot id: F0RUE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

158189:SPIBUDDY RS07945
gene id: 158189:SPIBUDDY_RS07945
uniprot id: F0RZA3
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS11775
gene id: 158189:SPIBUDDY_RS11775
uniprot id: F0RSM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

158189:SPIBUDDY RS06925
gene id: 158189:SPIBUDDY_RS06925
uniprot id: F0RVX2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

158189:SPIBUDDY RS05455
gene id: 158189:SPIBUDDY_RS05455
uniprot id: F0RVB7
names: Similarity
messages: Belongs to the ArsC family.

158189:SPIBUDDY RS04635
gene id: 158189:SPIBUDDY_RS04635
uniprot id: F0RYH6
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS05140
gene id: 158189:SPIBUDDY_RS05140
uniprot id: F0RYK3
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS10940
gene id: 158189:SPIBUDDY_RS10940
uniprot id: F0RSS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

158189:SPIBUDDY RS12710
gene id: 158189:SPIBUDDY_RS12710
uniprot id: F0RSC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS10995
gene id: 158189:SPIBUDDY_RS10995
uniprot id: F0RST3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS03355
gene id: 158189:SPIBUDDY_RS03355
uniprot id: F0RUR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

158189:SPIBUDDY RS11460
gene id: 158189:SPIBUDDY_RS11460
uniprot id: F0RTZ7
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS06365
gene id: 158189:SPIBUDDY_RS06365
uniprot id: F0RYU0
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

158189:SPIBUDDY RS05680
gene id: 158189:SPIBUDDY_RS05680
uniprot id: F0RVF8
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

158189:SPIBUDDY RS14610
gene id: 158189:SPIBUDDY_RS14610
uniprot id: F0RS88
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

158189:SPIBUDDY RS11455
gene id: 158189:SPIBUDDY_RS11455
uniprot id: F0RTZ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS14865
gene id: 158189:SPIBUDDY_RS14865
uniprot id: F0RTP5
names: Similarity
messages: Belongs to the PspA/IM30 family.

158189:SPIBUDDY RS12210
gene id: 158189:SPIBUDDY_RS12210
uniprot id: F0RRH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS04930
gene id: 158189:SPIBUDDY_RS04930
uniprot id: F0RV84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS13290
gene id: 158189:SPIBUDDY_RS13290
uniprot id: F0RT59
names: Similarity
messages: Belongs to the peptidase S33 family.

158189:SPIBUDDY RS00015
gene id: 158189:SPIBUDDY_RS00015
uniprot id: F0RWZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

158189:SPIBUDDY RS00660
gene id: 158189:SPIBUDDY_RS00660
uniprot id: F0RXC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS04235
gene id: 158189:SPIBUDDY_RS04235
uniprot id: F0RV20
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

158189:SPIBUDDY RS10925
gene id: 158189:SPIBUDDY_RS10925
uniprot id: F0RSR9
names: Similarity
messages: Belongs to the GARS family.

158189:SPIBUDDY RS06820
gene id: 158189:SPIBUDDY_RS06820
uniprot id: F0RVV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

158189:SPIBUDDY RS11180
gene id: 158189:SPIBUDDY_RS11180
uniprot id: F0RSW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS09050
gene id: 158189:SPIBUDDY_RS09050
uniprot id: F0RWH1
names: Similarity
messages: Belongs to the MEMO1 family.

158189:SPIBUDDY RS02370
gene id: 158189:SPIBUDDY_RS02370
uniprot id: F0RUE6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS14970
gene id: 158189:SPIBUDDY_RS14970
uniprot id: F0RZL2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

158189:SPIBUDDY RS14345
gene id: 158189:SPIBUDDY_RS14345
uniprot id: F0RS45
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

158189:SPIBUDDY RS04195
gene id: 158189:SPIBUDDY_RS04195
uniprot id: F0RV12
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.

158189:SPIBUDDY RS10640
gene id: 158189:SPIBUDDY_RS10640
uniprot id: F0RTK6
names: Function
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

158189:SPIBUDDY RS14185
gene id: 158189:SPIBUDDY_RS14185
uniprot id: F0RS11
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS09140
gene id: 158189:SPIBUDDY_RS09140
uniprot id: F0RWJ0
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

158189:SPIBUDDY RS05510
gene id: 158189:SPIBUDDY_RS05510
uniprot id: F0RVC3
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

158189:SPIBUDDY RS06500
gene id: 158189:SPIBUDDY_RS06500
uniprot id: F0RYW7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS02260
gene id: 158189:SPIBUDDY_RS02260
uniprot id: F0RUC4
names: Similarity
messages: Belongs to the BMP lipoprotein family.

158189:SPIBUDDY RS10700
gene id: 158189:SPIBUDDY_RS10700
uniprot id: F0RSX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

158189:SPIBUDDY RS05360
gene id: 158189:SPIBUDDY_RS05360
uniprot id: F0RYP8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

158189:SPIBUDDY RS06575
gene id: 158189:SPIBUDDY_RS06575
uniprot id: F0RYY1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

158189:SPIBUDDY RS05075
gene id: 158189:SPIBUDDY_RS05075
uniprot id: F0RVB1
names: Similarity
messages: Belongs to the glutathione peroxidase family.

158189:SPIBUDDY RS12935
gene id: 158189:SPIBUDDY_RS12935
uniprot id: F0RTE0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

158189:SPIBUDDY RS11410
gene id: 158189:SPIBUDDY_RS11410
uniprot id: F0RTY7
names: Similarity
messages: Belongs to the peptidase S66 family.

158189:SPIBUDDY RS02010
gene id: 158189:SPIBUDDY_RS02010
uniprot id: F0RXW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS14470
gene id: 158189:SPIBUDDY_RS14470
uniprot id: F0RS68
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

158189:SPIBUDDY RS06080
gene id: 158189:SPIBUDDY_RS06080
uniprot id: F0RVN4
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

158189:SPIBUDDY RS11160
gene id: 158189:SPIBUDDY_RS11160
uniprot id: F0RSW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

158189:SPIBUDDY RS11520
gene id: 158189:SPIBUDDY_RS11520
uniprot id: F0RSH4
names: Similarity
messages: Belongs to the LacAB/RpiB family.

158189:SPIBUDDY RS01315
gene id: 158189:SPIBUDDY_RS01315
uniprot id: F0RXQ1
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

158189:SPIBUDDY RS05155
gene id: 158189:SPIBUDDY_RS05155
uniprot id: F0RYK6
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

158189:SPIBUDDY RS09010
gene id: 158189:SPIBUDDY_RS09010
uniprot id: F0RWG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS05745
gene id: 158189:SPIBUDDY_RS05745
uniprot id: F0RVH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

158189:SPIBUDDY RS14340
gene id: 158189:SPIBUDDY_RS14340
uniprot id: F0RS44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

158189:SPIBUDDY RS09640
gene id: 158189:SPIBUDDY_RS09640
uniprot id: F0RWT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

158189:SPIBUDDY RS13730
gene id: 158189:SPIBUDDY_RS13730
uniprot id: F0RSB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

158189:SPIBUDDY RS02435
gene id: 158189:SPIBUDDY_RS02435
uniprot id: F0RUF9
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS09760
gene id: 158189:SPIBUDDY_RS09760
uniprot id: F0RWW2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

158189:SPIBUDDY RS03290
gene id: 158189:SPIBUDDY_RS03290
uniprot id: F0RUQ6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

158189:SPIBUDDY RS06230
gene id: 158189:SPIBUDDY_RS06230
uniprot id: F0RYS0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

158189:SPIBUDDY RS01170
gene id: 158189:SPIBUDDY_RS01170
uniprot id: F0RXM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS08660
gene id: 158189:SPIBUDDY_RS08660
uniprot id: F0RZH7
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.
messages: Binds 1 zinc ion per subunit.

158189:SPIBUDDY RS11215
gene id: 158189:SPIBUDDY_RS11215
uniprot id: F0RSX6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell inner membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

158189:SPIBUDDY RS07120
gene id: 158189:SPIBUDDY_RS07120
uniprot id: F0RZ14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

158189:SPIBUDDY RS07320
gene id: 158189:SPIBUDDY_RS07320
uniprot id: F0RZ54
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

158189:SPIBUDDY RS12775
gene id: 158189:SPIBUDDY_RS12775
uniprot id: F0RSD9
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS03120
gene id: 158189:SPIBUDDY_RS03120
uniprot id: F0RY27
names: Similarity
messages: Belongs to the ice-binding protein family.

158189:SPIBUDDY RS15395
gene id: 158189:SPIBUDDY_RS15395
uniprot id: F0RZU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

158189:SPIBUDDY RS06165
gene id: 158189:SPIBUDDY_RS06165
uniprot id: F0RVQ1
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

158189:SPIBUDDY RS05780
gene id: 158189:SPIBUDDY_RS05780
uniprot id: F0RVH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

158189:SPIBUDDY RS10690
gene id: 158189:SPIBUDDY_RS10690
uniprot id: F0RSN7
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS10645
gene id: 158189:SPIBUDDY_RS10645
uniprot id: F0RTK7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

158189:SPIBUDDY RS06280
gene id: 158189:SPIBUDDY_RS06280
uniprot id: F0RYT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

158189:SPIBUDDY RS09890
gene id: 158189:SPIBUDDY_RS09890
uniprot id: F0RWY6
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

158189:SPIBUDDY RS09800
gene id: 158189:SPIBUDDY_RS09800
uniprot id: F0RWW9
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

158189:SPIBUDDY RS14435
gene id: 158189:SPIBUDDY_RS14435
uniprot id: F0RS63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

158189:SPIBUDDY RS05965
gene id: 158189:SPIBUDDY_RS05965
uniprot id: F0RVL1
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

158189:SPIBUDDY RS14285
gene id: 158189:SPIBUDDY_RS14285
uniprot id: F0RS31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

158189:SPIBUDDY RS05570
gene id: 158189:SPIBUDDY_RS05570
uniprot id: F0RVD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

158189:SPIBUDDY RS06735
gene id: 158189:SPIBUDDY_RS06735
uniprot id: F0RVT4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

158189:SPIBUDDY RS03450
gene id: 158189:SPIBUDDY_RS03450
uniprot id: F0RUT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

158189:SPIBUDDY RS07055
gene id: 158189:SPIBUDDY_RS07055
uniprot id: F0RZ01
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

158189:SPIBUDDY RS15610
gene id: 158189:SPIBUDDY_RS15610
uniprot id: F0RY29
names: Similarity
messages: Belongs to the ice-binding protein family.

158189:SPIBUDDY RS14405
gene id: 158189:SPIBUDDY_RS14405
uniprot id: F0RS57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

158189:SPIBUDDY RS07185
gene id: 158189:SPIBUDDY_RS07185
uniprot id: F0RZ27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

158189:SPIBUDDY RS13960
gene id: 158189:SPIBUDDY_RS13960
uniprot id: F0RRW7
names: Similarity
messages: Belongs to the Fur family.

158189:SPIBUDDY RS06375
gene id: 158189:SPIBUDDY_RS06375
uniprot id: F0RYU2
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

158189:SPIBUDDY RS09870
gene id: 158189:SPIBUDDY_RS09870
uniprot id: F0RWY2
names: Subcellular Location Annotation
messages: Nucleus

158189:SPIBUDDY RS05925
gene id: 158189:SPIBUDDY_RS05925
uniprot id: F0RVK3
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

158189:SPIBUDDY RS10790
gene id: 158189:SPIBUDDY_RS10790
uniprot id: F0RSZ6
names: Similarity
messages: Belongs to the DprA/Smf family.

158189:SPIBUDDY RS04760
gene id: 158189:SPIBUDDY_RS04760
uniprot id: F0RV50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS14025
gene id: 158189:SPIBUDDY_RS14025
uniprot id: F0RRY0
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS05865
gene id: 158189:SPIBUDDY_RS05865
uniprot id: F0RVJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS08810
gene id: 158189:SPIBUDDY_RS08810
uniprot id: F0RWC5
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

158189:SPIBUDDY RS11330
gene id: 158189:SPIBUDDY_RS11330
uniprot id: F0RTX1
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS08510
gene id: 158189:SPIBUDDY_RS08510
uniprot id: F0RZE7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

158189:SPIBUDDY RS09910
gene id: 158189:SPIBUDDY_RS09910
uniprot id: F0RWZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS02895
gene id: 158189:SPIBUDDY_RS02895
uniprot id: F0RXY9
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

158189:SPIBUDDY RS10555
gene id: 158189:SPIBUDDY_RS10555
uniprot id: F0RTJ0
names: Cofactor
messages: Binds 2 Mg(2+) ions per monomer.

158189:SPIBUDDY RS09860
gene id: 158189:SPIBUDDY_RS09860
uniprot id: F0RWY0
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

158189:SPIBUDDY RS08475
gene id: 158189:SPIBUDDY_RS08475
uniprot id: F0RZE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

158189:SPIBUDDY RS15785
gene id: 158189:SPIBUDDY_RS15785
uniprot id: F0RSU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

158189:SPIBUDDY RS14420
gene id: 158189:SPIBUDDY_RS14420
uniprot id: F0RS60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

158189:SPIBUDDY RS09820
gene id: 158189:SPIBUDDY_RS09820
uniprot id: F0RWX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

158189:SPIBUDDY RS06760
gene id: 158189:SPIBUDDY_RS06760
uniprot id: F0RVT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

158189:SPIBUDDY RS14335
gene id: 158189:SPIBUDDY_RS14335
uniprot id: F0RS43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

158189:SPIBUDDY RS09075
gene id: 158189:SPIBUDDY_RS09075
uniprot id: F0RWH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

158189:SPIBUDDY RS04215
gene id: 158189:SPIBUDDY_RS04215
uniprot id: F0RV16
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

158189:SPIBUDDY RS15725
gene id: 158189:SPIBUDDY_RS15725
uniprot id: F0RWY1
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

158189:SPIBUDDY RS15335
gene id: 158189:SPIBUDDY_RS15335
uniprot id: F0RZT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

158189:SPIBUDDY RS02135
gene id: 158189:SPIBUDDY_RS02135
uniprot id: F0RUA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS08385
gene id: 158189:SPIBUDDY_RS08385
uniprot id: F0RWB6
names: Similarity
messages: Belongs to the carbamate kinase family.

158189:SPIBUDDY RS06010
gene id: 158189:SPIBUDDY_RS06010
uniprot id: F0RVM0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

158189:SPIBUDDY RS05040
gene id: 158189:SPIBUDDY_RS05040
uniprot id: F0RVA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS02290
gene id: 158189:SPIBUDDY_RS02290
uniprot id: F0RUD0
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

158189:SPIBUDDY RS14820
gene id: 158189:SPIBUDDY_RS14820
uniprot id: F0RTN6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

158189:SPIBUDDY RS08005
gene id: 158189:SPIBUDDY_RS08005
uniprot id: F0RZB5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

158189:SPIBUDDY RS13395
gene id: 158189:SPIBUDDY_RS13395
uniprot id: F0RTB8
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS14290
gene id: 158189:SPIBUDDY_RS14290
uniprot id: F0RS33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

158189:SPIBUDDY RS15050
gene id: 158189:SPIBUDDY_RS15050
uniprot id: F0RZM8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS10020
gene id: 158189:SPIBUDDY_RS10020
uniprot id: F0RZW3
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS03610
gene id: 158189:SPIBUDDY_RS03610
uniprot id: F0RUW9
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

158189:SPIBUDDY RS11220
gene id: 158189:SPIBUDDY_RS11220
uniprot id: F0RSX7
names: Similarity
messages: Belongs to the threonine aldolase family.

158189:SPIBUDDY RS08405
gene id: 158189:SPIBUDDY_RS08405
uniprot id: F0RWC0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

158189:SPIBUDDY RS07040
gene id: 158189:SPIBUDDY_RS07040
uniprot id: F0RYZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

158189:SPIBUDDY RS07355
gene id: 158189:SPIBUDDY_RS07355
uniprot id: F0RVY2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

158189:SPIBUDDY RS00980
gene id: 158189:SPIBUDDY_RS00980
uniprot id: F0RXI7
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

158189:SPIBUDDY RS13705
gene id: 158189:SPIBUDDY_RS13705
uniprot id: F0RSB2
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

158189:SPIBUDDY RS09625
gene id: 158189:SPIBUDDY_RS09625
uniprot id: F0RWT6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

158189:SPIBUDDY RS02955
gene id: 158189:SPIBUDDY_RS02955
uniprot id: F0RY01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

158189:SPIBUDDY RS00690
gene id: 158189:SPIBUDDY_RS00690
uniprot id: F0RXD0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

158189:SPIBUDDY RS15105
gene id: 158189:SPIBUDDY_RS15105
uniprot id: F0RZN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

158189:SPIBUDDY RS07980
gene id: 158189:SPIBUDDY_RS07980
uniprot id: F0RZA9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

158189:SPIBUDDY RS10050
gene id: 158189:SPIBUDDY_RS10050
uniprot id: F0RTQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

158189:SPIBUDDY RS01940
gene id: 158189:SPIBUDDY_RS01940
uniprot id: F0RXU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

158189:SPIBUDDY RS05725
gene id: 158189:SPIBUDDY_RS05725
uniprot id: F0RVG7
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS00115
gene id: 158189:SPIBUDDY_RS00115
uniprot id: F0RX19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

158189:SPIBUDDY RS06460
gene id: 158189:SPIBUDDY_RS06460
uniprot id: F0RYV9
names: Similarity
messages: Belongs to the DprA/Smf family.

158189:SPIBUDDY RS04315
gene id: 158189:SPIBUDDY_RS04315
uniprot id: F0RV36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS06400
gene id: 158189:SPIBUDDY_RS06400
uniprot id: F0RYU7
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

158189:SPIBUDDY RS14235
gene id: 158189:SPIBUDDY_RS14235
uniprot id: F0RS21
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

158189:SPIBUDDY RS13830
gene id: 158189:SPIBUDDY_RS13830
uniprot id: F0RRU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS14090
gene id: 158189:SPIBUDDY_RS14090
uniprot id: F0RRZ2
names: Function
names: Similarity
messages: Belongs to the UxaE family.
messages: Catalyzes the epimerization of D-tagaturonate (D-TagA) to D-fructuronate (D-FruA).

158189:SPIBUDDY RS10265
gene id: 158189:SPIBUDDY_RS10265
uniprot id: F0RTS7
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

158189:SPIBUDDY RS10950
gene id: 158189:SPIBUDDY_RS10950
uniprot id: F0RSS4
names: Similarity
messages: Belongs to the SAICAR synthetase family.

158189:SPIBUDDY RS13045
gene id: 158189:SPIBUDDY_RS13045
uniprot id: F0RT91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

158189:SPIBUDDY RS10320
gene id: 158189:SPIBUDDY_RS10320
uniprot id: F0RTT8
names: Similarity
messages: Belongs to the thioredoxin family.

158189:SPIBUDDY RS12305
gene id: 158189:SPIBUDDY_RS12305
uniprot id: F0RRJ3
names: Similarity
messages: Belongs to the BMP lipoprotein family.

158189:SPIBUDDY RS12440
gene id: 158189:SPIBUDDY_RS12440
uniprot id: F0RRL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS01930
gene id: 158189:SPIBUDDY_RS01930
uniprot id: F0RXU6
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

158189:SPIBUDDY RS07530
gene id: 158189:SPIBUDDY_RS07530
uniprot id: F0RW16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

158189:SPIBUDDY RS04800
gene id: 158189:SPIBUDDY_RS04800
uniprot id: F0RV58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

158189:SPIBUDDY RS07460
gene id: 158189:SPIBUDDY_RS07460
uniprot id: F0RW03
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

158189:SPIBUDDY RS05340
gene id: 158189:SPIBUDDY_RS05340
uniprot id: F0RYP4
names: Similarity
messages: Belongs to the glutathione peroxidase family.

158189:SPIBUDDY RS04055
gene id: 158189:SPIBUDDY_RS04055
uniprot id: F0RUY4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

158189:SPIBUDDY RS03950
gene id: 158189:SPIBUDDY_RS03950
uniprot id: F0RYB6
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

158189:SPIBUDDY RS00615
gene id: 158189:SPIBUDDY_RS00615
uniprot id: F0RXB6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

158189:SPIBUDDY RS14220
gene id: 158189:SPIBUDDY_RS14220
uniprot id: F0RS18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

158189:SPIBUDDY RS07135
gene id: 158189:SPIBUDDY_RS07135
uniprot id: F0RZ17
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA.

158189:SPIBUDDY RS10375
gene id: 158189:SPIBUDDY_RS10375
uniprot id: F0RU04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

158189:SPIBUDDY RS02680
gene id: 158189:SPIBUDDY_RS02680
uniprot id: F0RUK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS02765
gene id: 158189:SPIBUDDY_RS02765
uniprot id: F0RUM6
names: Similarity
messages: Belongs to the BMP lipoprotein family.

158189:SPIBUDDY RS14910
gene id: 158189:SPIBUDDY_RS14910
uniprot id: F0RTQ3
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS11585
gene id: 158189:SPIBUDDY_RS11585
uniprot id: F0RSI6
names: Similarity
messages: Belongs to the class-I fumarase family.

158189:SPIBUDDY RS15110
gene id: 158189:SPIBUDDY_RS15110
uniprot id: F0RZP0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

158189:SPIBUDDY RS00150
gene id: 158189:SPIBUDDY_RS00150
uniprot id: F0RX26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

158189:SPIBUDDY RS07195
gene id: 158189:SPIBUDDY_RS07195
uniprot id: F0RZ29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

158189:SPIBUDDY RS08125
gene id: 158189:SPIBUDDY_RS08125
uniprot id: F0RW63
names: Similarity
messages: Belongs to the UPF0047 family.

158189:SPIBUDDY RS01220
gene id: 158189:SPIBUDDY_RS01220
uniprot id: F0RXN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS04740
gene id: 158189:SPIBUDDY_RS04740
uniprot id: F0RV46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

158189:SPIBUDDY RS10505
gene id: 158189:SPIBUDDY_RS10505
uniprot id: F0RZZ0
names: Similarity
messages: Belongs to the UMP kinase family.

158189:SPIBUDDY RS11155
gene id: 158189:SPIBUDDY_RS11155
uniprot id: F0RSW2
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

158189:SPIBUDDY RS12290
gene id: 158189:SPIBUDDY_RS12290
uniprot id: F0RRJ0
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS08540
gene id: 158189:SPIBUDDY_RS08540
uniprot id: F0RZF3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

158189:SPIBUDDY RS13940
gene id: 158189:SPIBUDDY_RS13940
uniprot id: F0RRW3
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS02380
gene id: 158189:SPIBUDDY_RS02380
uniprot id: F0RUE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

158189:SPIBUDDY RS08085
gene id: 158189:SPIBUDDY_RS08085
uniprot id: F0RW55
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS09920
gene id: 158189:SPIBUDDY_RS09920
uniprot id: F0RWZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

158189:SPIBUDDY RS04185
gene id: 158189:SPIBUDDY_RS04185
uniprot id: F0RV10
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

158189:SPIBUDDY RS02755
gene id: 158189:SPIBUDDY_RS02755
uniprot id: F0RUM4
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS00610
gene id: 158189:SPIBUDDY_RS00610
uniprot id: F0RXB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

158189:SPIBUDDY RS04570
gene id: 158189:SPIBUDDY_RS04570
uniprot id: F0RYG3
names: Similarity
messages: Belongs to the FGGY kinase family.

158189:SPIBUDDY RS02865
gene id: 158189:SPIBUDDY_RS02865
uniprot id: F0RXY3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.

158189:SPIBUDDY RS10730
gene id: 158189:SPIBUDDY_RS10730
uniprot id: F0RSY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

158189:SPIBUDDY RS07380
gene id: 158189:SPIBUDDY_RS07380
uniprot id: F0RVY7
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

158189:SPIBUDDY RS05905
gene id: 158189:SPIBUDDY_RS05905
uniprot id: F0RVJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

158189:SPIBUDDY RS09895
gene id: 158189:SPIBUDDY_RS09895
uniprot id: F0RWY7
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

158189:SPIBUDDY RS09660
gene id: 158189:SPIBUDDY_RS09660
uniprot id: F0RWU3
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

158189:SPIBUDDY RS08455
gene id: 158189:SPIBUDDY_RS08455
uniprot id: F0RZD6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

158189:SPIBUDDY RS10765
gene id: 158189:SPIBUDDY_RS10765
uniprot id: F0RSZ1
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS10150
gene id: 158189:SPIBUDDY_RS10150
uniprot id: F0RTU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

158189:SPIBUDDY RS15005
gene id: 158189:SPIBUDDY_RS15005
uniprot id: F0RZL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

158189:SPIBUDDY RS04170
gene id: 158189:SPIBUDDY_RS04170
uniprot id: F0RV07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

158189:SPIBUDDY RS12340
gene id: 158189:SPIBUDDY_RS12340
uniprot id: F0RRS0
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

158189:SPIBUDDY RS04590
gene id: 158189:SPIBUDDY_RS04590
uniprot id: F0RYG7
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS01085
gene id: 158189:SPIBUDDY_RS01085
uniprot id: F0RXK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

158189:SPIBUDDY RS02360
gene id: 158189:SPIBUDDY_RS02360
uniprot id: F0RUE4
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

158189:SPIBUDDY RS12860
gene id: 158189:SPIBUDDY_RS12860
uniprot id: F0RSF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

158189:SPIBUDDY RS02600
gene id: 158189:SPIBUDDY_RS02600
uniprot id: F0RUJ3
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

158189:SPIBUDDY RS00215
gene id: 158189:SPIBUDDY_RS00215
uniprot id: F0RX38
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS00170
gene id: 158189:SPIBUDDY_RS00170
uniprot id: F0RX30
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

158189:SPIBUDDY RS11580
gene id: 158189:SPIBUDDY_RS11580
uniprot id: F0RSK2
names: Similarity
messages: Belongs to the class-I fumarase family.

158189:SPIBUDDY RS04815
gene id: 158189:SPIBUDDY_RS04815
uniprot id: F0RV61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

158189:SPIBUDDY RS04810
gene id: 158189:SPIBUDDY_RS04810
uniprot id: F0RV60
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

158189:SPIBUDDY RS11310
gene id: 158189:SPIBUDDY_RS11310
uniprot id: F0RTH1
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

158189:SPIBUDDY RS10770
gene id: 158189:SPIBUDDY_RS10770
uniprot id: F0RSZ2
names: Subcellular Location Annotation
messages: Cytoplasm

158189:SPIBUDDY RS05785
gene id: 158189:SPIBUDDY_RS05785
uniprot id: F0RVH8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

158189:SPIBUDDY RS15270
gene id: 158189:SPIBUDDY_RS15270
uniprot id: F0RZS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS00315
gene id: 158189:SPIBUDDY_RS00315
uniprot id: F0RX58
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS12990
gene id: 158189:SPIBUDDY_RS12990
uniprot id: F0RT75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

158189:SPIBUDDY RS07515
gene id: 158189:SPIBUDDY_RS07515
uniprot id: F0RW13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

158189:SPIBUDDY RS08035
gene id: 158189:SPIBUDDY_RS08035
uniprot id: F0RZC1
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

158189:SPIBUDDY RS13000
gene id: 158189:SPIBUDDY_RS13000
uniprot id: F0RT77
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

158189:SPIBUDDY RS05675
gene id: 158189:SPIBUDDY_RS05675
uniprot id: F0RVF7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

158189:SPIBUDDY RS14190
gene id: 158189:SPIBUDDY_RS14190
uniprot id: F0RS12
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS12925
gene id: 158189:SPIBUDDY_RS12925
uniprot id: F0RTD8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

158189:SPIBUDDY RS04825
gene id: 158189:SPIBUDDY_RS04825
uniprot id: F0RV63
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS15020
gene id: 158189:SPIBUDDY_RS15020
uniprot id: F0RZM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS14390
gene id: 158189:SPIBUDDY_RS14390
uniprot id: F0RS54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

158189:SPIBUDDY RS10635
gene id: 158189:SPIBUDDY_RS10635
uniprot id: F0RTK5
names: Function
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

158189:SPIBUDDY RS02625
gene id: 158189:SPIBUDDY_RS02625
uniprot id: F0RUJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS04040
gene id: 158189:SPIBUDDY_RS04040
uniprot id: F0RUY1
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS01215
gene id: 158189:SPIBUDDY_RS01215
uniprot id: F0RXN3
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

158189:SPIBUDDY RS03920
gene id: 158189:SPIBUDDY_RS03920
uniprot id: F0RYB0
names: Similarity
messages: Belongs to the sigma-54 factor family.

158189:SPIBUDDY RS09130
gene id: 158189:SPIBUDDY_RS09130
uniprot id: F0RWI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

158189:SPIBUDDY RS05235
gene id: 158189:SPIBUDDY_RS05235
uniprot id: F0RYM2
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

158189:SPIBUDDY RS14855
gene id: 158189:SPIBUDDY_RS14855
uniprot id: F0RTP3
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS13540
gene id: 158189:SPIBUDDY_RS13540
uniprot id: F0RT44
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS10465
gene id: 158189:SPIBUDDY_RS10465
uniprot id: F0RZY2
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS00945
gene id: 158189:SPIBUDDY_RS00945
uniprot id: F0RXI0
names: Similarity
messages: Belongs to the UxaA family.

158189:SPIBUDDY RS07370
gene id: 158189:SPIBUDDY_RS07370
uniprot id: F0RVY5
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS11355
gene id: 158189:SPIBUDDY_RS11355
uniprot id: F0RTX6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rhamnose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
messages: Cytoplasm

158189:SPIBUDDY RS01705
gene id: 158189:SPIBUDDY_RS01705
uniprot id: F0RU92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS02590
gene id: 158189:SPIBUDDY_RS02590
uniprot id: F0RUJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS06845
gene id: 158189:SPIBUDDY_RS06845
uniprot id: F0RVV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

158189:SPIBUDDY RS10190
gene id: 158189:SPIBUDDY_RS10190
uniprot id: F0RTV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

158189:SPIBUDDY RS06550
gene id: 158189:SPIBUDDY_RS06550
uniprot id: F0RYX7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the KduI family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.

158189:SPIBUDDY RS14365
gene id: 158189:SPIBUDDY_RS14365
uniprot id: F0RS49
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

158189:SPIBUDDY RS13850
gene id: 158189:SPIBUDDY_RS13850
uniprot id: F0RRU5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

158189:SPIBUDDY RS08795
gene id: 158189:SPIBUDDY_RS08795
uniprot id: F0RZK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS15775
gene id: 158189:SPIBUDDY_RS15775
uniprot id: F0RSS1
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS08355
gene id: 158189:SPIBUDDY_RS08355
uniprot id: F0RWB0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

158189:SPIBUDDY RS01895
gene id: 158189:SPIBUDDY_RS01895
uniprot id: F0RXT9
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

158189:SPIBUDDY RS05055
gene id: 158189:SPIBUDDY_RS05055
uniprot id: F0RVA9
names: Similarity
messages: Belongs to the glutathione peroxidase family.

158189:SPIBUDDY RS07285
gene id: 158189:SPIBUDDY_RS07285
uniprot id: F0RZ47
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

158189:SPIBUDDY RS10130
gene id: 158189:SPIBUDDY_RS10130
uniprot id: F0RTS5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

158189:SPIBUDDY RS10590
gene id: 158189:SPIBUDDY_RS10590
uniprot id: F0RTJ7
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

158189:SPIBUDDY RS09655
gene id: 158189:SPIBUDDY_RS09655
uniprot id: F0RWU2
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

158189:SPIBUDDY RS05560
gene id: 158189:SPIBUDDY_RS05560
uniprot id: F0RVD3
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

158189:SPIBUDDY RS08300
gene id: 158189:SPIBUDDY_RS08300
uniprot id: F0RW99
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

158189:SPIBUDDY RS11070
gene id: 158189:SPIBUDDY_RS11070
uniprot id: F0RSU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

158189:SPIBUDDY RS10800
gene id: 158189:SPIBUDDY_RS10800
uniprot id: F0RSZ8
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

158189:SPIBUDDY RS04125
gene id: 158189:SPIBUDDY_RS04125
uniprot id: F0RUZ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

158189:SPIBUDDY RS06655
gene id: 158189:SPIBUDDY_RS06655
uniprot id: F0RVR8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

158189:SPIBUDDY RS11545
gene id: 158189:SPIBUDDY_RS11545
uniprot id: F0RSH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

158189:SPIBUDDY RS04455
gene id: 158189:SPIBUDDY_RS04455
uniprot id: F0RYE1
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

158189:SPIBUDDY RS09650
gene id: 158189:SPIBUDDY_RS09650
uniprot id: F0RWU1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

158189:SPIBUDDY RS05450
gene id: 158189:SPIBUDDY_RS05450
uniprot id: F0RVB6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

158189:SPIBUDDY RS11475
gene id: 158189:SPIBUDDY_RS11475
uniprot id: F0RSG5
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

158189:SPIBUDDY RS06530
gene id: 158189:SPIBUDDY_RS06530
uniprot id: F0RYX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

158189:SPIBUDDY RS10030
gene id: 158189:SPIBUDDY_RS10030
uniprot id: F0RZW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

158189:SPIBUDDY RS08470
gene id: 158189:SPIBUDDY_RS08470
uniprot id: F0RZD9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

158189:SPIBUDDY RS03335
gene id: 158189:SPIBUDDY_RS03335
uniprot id: F0RUR5
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

158189:SPIBUDDY RS05395
gene id: 158189:SPIBUDDY_RS05395
uniprot id: F0RYQ5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

158189:SPIBUDDY RS14280
gene id: 158189:SPIBUDDY_RS14280
uniprot id: F0RS30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

158189:SPIBUDDY RS13425
gene id: 158189:SPIBUDDY_RS13425
uniprot id: F0RT21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS04160
gene id: 158189:SPIBUDDY_RS04160
uniprot id: F0RV05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS10545
gene id: 158189:SPIBUDDY_RS10545
uniprot id: F0RTI8
names: Similarity
messages: Belongs to the hexokinase family.

158189:SPIBUDDY RS01040
gene id: 158189:SPIBUDDY_RS01040
uniprot id: F0RXJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS14275
gene id: 158189:SPIBUDDY_RS14275
uniprot id: F0RS29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

158189:SPIBUDDY RS07630
gene id: 158189:SPIBUDDY_RS07630
uniprot id: F0RW35
names: Similarity
messages: Belongs to the arginase family.

158189:SPIBUDDY RS02770
gene id: 158189:SPIBUDDY_RS02770
uniprot id: F0RUM7
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

158189:SPIBUDDY RS09190
gene id: 158189:SPIBUDDY_RS09190
uniprot id: F0RWK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS09615
gene id: 158189:SPIBUDDY_RS09615
uniprot id: F0RWT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

158189:SPIBUDDY RS15180
gene id: 158189:SPIBUDDY_RS15180
uniprot id: F0RZQ3
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS04370
gene id: 158189:SPIBUDDY_RS04370
uniprot id: F0RYC6
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS07755
gene id: 158189:SPIBUDDY_RS07755
uniprot id: F0RZ65
names: Similarity
messages: Belongs to the catalase family.

158189:SPIBUDDY RS03215
gene id: 158189:SPIBUDDY_RS03215
uniprot id: F0RY45
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

158189:SPIBUDDY RS02205
gene id: 158189:SPIBUDDY_RS02205
uniprot id: F0RUB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS08120
gene id: 158189:SPIBUDDY_RS08120
uniprot id: F0RW62
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

158189:SPIBUDDY RS15435
gene id: 158189:SPIBUDDY_RS15435
uniprot id: F0RZU8
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

158189:SPIBUDDY RS02330
gene id: 158189:SPIBUDDY_RS02330
uniprot id: F0RUD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TER reductase family.
messages: Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA).
messages: Monomer.

158189:SPIBUDDY RS02425
gene id: 158189:SPIBUDDY_RS02425
uniprot id: F0RUF7
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

158189:SPIBUDDY RS00395
gene id: 158189:SPIBUDDY_RS00395
uniprot id: F0RX74
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

158189:SPIBUDDY RS05525
gene id: 158189:SPIBUDDY_RS05525
uniprot id: F0RVC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

158189:SPIBUDDY RS02040
gene id: 158189:SPIBUDDY_RS02040
uniprot id: F0RXW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS11305
gene id: 158189:SPIBUDDY_RS11305
uniprot id: F0RTH0
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

158189:SPIBUDDY RS10330
gene id: 158189:SPIBUDDY_RS10330
uniprot id: F0RTU3
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS14510
gene id: 158189:SPIBUDDY_RS14510
uniprot id: F0RS77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

158189:SPIBUDDY RS08360
gene id: 158189:SPIBUDDY_RS08360
uniprot id: F0RWB1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

158189:SPIBUDDY RS14380
gene id: 158189:SPIBUDDY_RS14380
uniprot id: F0RS52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

158189:SPIBUDDY RS12525
gene id: 158189:SPIBUDDY_RS12525
uniprot id: F0RRN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

158189:SPIBUDDY RS03025
gene id: 158189:SPIBUDDY_RS03025
uniprot id: F0RY11
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

158189:SPIBUDDY RS03715
gene id: 158189:SPIBUDDY_RS03715
uniprot id: F0RY69
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS04555
gene id: 158189:SPIBUDDY_RS04555
uniprot id: F0RYF9
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

158189:SPIBUDDY RS06870
gene id: 158189:SPIBUDDY_RS06870
uniprot id: F0RVW1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

158189:SPIBUDDY RS08425
gene id: 158189:SPIBUDDY_RS08425
uniprot id: F0RZC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

158189:SPIBUDDY RS13900
gene id: 158189:SPIBUDDY_RS13900
uniprot id: F0RRV5
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

158189:SPIBUDDY RS04140
gene id: 158189:SPIBUDDY_RS04140
uniprot id: F0RV01
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS05000
gene id: 158189:SPIBUDDY_RS05000
uniprot id: F0RV98
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

158189:SPIBUDDY RS06155
gene id: 158189:SPIBUDDY_RS06155
uniprot id: F0RVP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

158189:SPIBUDDY RS04155
gene id: 158189:SPIBUDDY_RS04155
uniprot id: F0RV04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS12520
gene id: 158189:SPIBUDDY_RS12520
uniprot id: F0RRN0
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

158189:SPIBUDDY RS06640
gene id: 158189:SPIBUDDY_RS06640
uniprot id: F0RVR5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

158189:SPIBUDDY RS04545
gene id: 158189:SPIBUDDY_RS04545
uniprot id: F0RYF7
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

158189:SPIBUDDY RS14675
gene id: 158189:SPIBUDDY_RS14675
uniprot id: F0RSA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

158189:SPIBUDDY RS15350
gene id: 158189:SPIBUDDY_RS15350
uniprot id: F0RZT7
names: Similarity
messages: Belongs to the IMPACT family.

158189:SPIBUDDY RS11610
gene id: 158189:SPIBUDDY_RS11610
uniprot id: F0RSJ1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

158189:SPIBUDDY RS03975
gene id: 158189:SPIBUDDY_RS03975
uniprot id: F0RYC0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

158189:SPIBUDDY RS09015
gene id: 158189:SPIBUDDY_RS09015
uniprot id: F0RWG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS13790
gene id: 158189:SPIBUDDY_RS13790
uniprot id: F0RRT3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

158189:SPIBUDDY RS12310
gene id: 158189:SPIBUDDY_RS12310
uniprot id: F0RRJ4
names: Similarity
messages: Belongs to the BtpA family.

158189:SPIBUDDY RS02805
gene id: 158189:SPIBUDDY_RS02805
uniprot id: F0RUN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

158189:SPIBUDDY RS14560
gene id: 158189:SPIBUDDY_RS14560
uniprot id: F0RS83
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS03815
gene id: 158189:SPIBUDDY_RS03815
uniprot id: F0RY89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS15700
gene id: 158189:SPIBUDDY_RS15700
uniprot id: F0RWD5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

158189:SPIBUDDY RS10230
gene id: 158189:SPIBUDDY_RS10230
uniprot id: F0RTW4
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

158189:SPIBUDDY RS03480
gene id: 158189:SPIBUDDY_RS03480
uniprot id: F0RUU3
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

158189:SPIBUDDY RS04015
gene id: 158189:SPIBUDDY_RS04015
uniprot id: F0RUX6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

158189:SPIBUDDY RS03075
gene id: 158189:SPIBUDDY_RS03075
uniprot id: F0RY21
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS12650
gene id: 158189:SPIBUDDY_RS12650
uniprot id: F0RRQ6
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS14795
gene id: 158189:SPIBUDDY_RS14795
uniprot id: F0RTN1
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

158189:SPIBUDDY RS04890
gene id: 158189:SPIBUDDY_RS04890
uniprot id: F0RV76
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

158189:SPIBUDDY RS11415
gene id: 158189:SPIBUDDY_RS11415
uniprot id: F0RTY8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

158189:SPIBUDDY RS13160
gene id: 158189:SPIBUDDY_RS13160
uniprot id: F0RTC9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

158189:SPIBUDDY RS09815
gene id: 158189:SPIBUDDY_RS09815
uniprot id: F0RWX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

158189:SPIBUDDY RS04765
gene id: 158189:SPIBUDDY_RS04765
uniprot id: F0RV51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS14300
gene id: 158189:SPIBUDDY_RS14300
uniprot id: F0RS35
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

158189:SPIBUDDY RS00280
gene id: 158189:SPIBUDDY_RS00280
uniprot id: F0RX51
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

158189:SPIBUDDY RS07570
gene id: 158189:SPIBUDDY_RS07570
uniprot id: F0RW24
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

158189:SPIBUDDY RS03240
gene id: 158189:SPIBUDDY_RS03240
uniprot id: F0RUP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS06015
gene id: 158189:SPIBUDDY_RS06015
uniprot id: F0RVM1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

158189:SPIBUDDY RS06580
gene id: 158189:SPIBUDDY_RS06580
uniprot id: F0RYY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

158189:SPIBUDDY RS05185
gene id: 158189:SPIBUDDY_RS05185
uniprot id: F0RYL2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

158189:SPIBUDDY RS05335
gene id: 158189:SPIBUDDY_RS05335
uniprot id: F0RYP3
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

158189:SPIBUDDY RS10655
gene id: 158189:SPIBUDDY_RS10655
uniprot id: F0RTK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

158189:SPIBUDDY RS00565
gene id: 158189:SPIBUDDY_RS00565
uniprot id: F0RXA7
names: Similarity
messages: Belongs to the glutamate synthase family.

158189:SPIBUDDY RS05580
gene id: 158189:SPIBUDDY_RS05580
uniprot id: F0RVD7
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

158189:SPIBUDDY RS03460
gene id: 158189:SPIBUDDY_RS03460
uniprot id: F0RUU0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS02845
gene id: 158189:SPIBUDDY_RS02845
uniprot id: F0RUP1
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

158189:SPIBUDDY RS09775
gene id: 158189:SPIBUDDY_RS09775
uniprot id: F0RWW5
names: Similarity
messages: Belongs to the Fur family.

158189:SPIBUDDY RS15605
gene id: 158189:SPIBUDDY_RS15605
uniprot id: F0RY28
names: Similarity
messages: Belongs to the ice-binding protein family.

158189:SPIBUDDY RS01225
gene id: 158189:SPIBUDDY_RS01225
uniprot id: F0RXN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS14000
gene id: 158189:SPIBUDDY_RS14000
uniprot id: F0RRX5
names: Similarity
messages: Belongs to the pirin family.

158189:SPIBUDDY RS03590
gene id: 158189:SPIBUDDY_RS03590
uniprot id: F0RUW5
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

158189:SPIBUDDY RS01800
gene id: 158189:SPIBUDDY_RS01800
uniprot id: F0RXS0
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS02025
gene id: 158189:SPIBUDDY_RS02025
uniprot id: F0RXW3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CutC family.
messages: Cytoplasm
messages: Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.

158189:SPIBUDDY RS15405
gene id: 158189:SPIBUDDY_RS15405
uniprot id: F0RZU3
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

158189:SPIBUDDY RS15895
gene id: 158189:SPIBUDDY_RS15895
uniprot id: F0RT47
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS05355
gene id: 158189:SPIBUDDY_RS05355
uniprot id: F0RYP7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

158189:SPIBUDDY RS06470
gene id: 158189:SPIBUDDY_RS06470
uniprot id: F0RYW1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

158189:SPIBUDDY RS06695
gene id: 158189:SPIBUDDY_RS06695
uniprot id: F0RVS6
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

158189:SPIBUDDY RS04805
gene id: 158189:SPIBUDDY_RS04805
uniprot id: F0RV59
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

158189:SPIBUDDY RS14110
gene id: 158189:SPIBUDDY_RS14110
uniprot id: F0RRZ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

158189:SPIBUDDY RS08715
gene id: 158189:SPIBUDDY_RS08715
uniprot id: F0RZI7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

158189:SPIBUDDY RS07310
gene id: 158189:SPIBUDDY_RS07310
uniprot id: F0RZ52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

158189:SPIBUDDY RS00485
gene id: 158189:SPIBUDDY_RS00485
uniprot id: F0RX92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS06060
gene id: 158189:SPIBUDDY_RS06060
uniprot id: F0RVN0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

158189:SPIBUDDY RS10070
gene id: 158189:SPIBUDDY_RS10070
uniprot id: F0RTR3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

158189:SPIBUDDY RS05475
gene id: 158189:SPIBUDDY_RS05475
uniprot id: F0RVC1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

158189:SPIBUDDY RS06160
gene id: 158189:SPIBUDDY_RS06160
uniprot id: F0RVQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

158189:SPIBUDDY RS01160
gene id: 158189:SPIBUDDY_RS01160
uniprot id: F0RXM2
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

158189:SPIBUDDY RS06660
gene id: 158189:SPIBUDDY_RS06660
uniprot id: F0RVR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

158189:SPIBUDDY RS11505
gene id: 158189:SPIBUDDY_RS11505
uniprot id: F0RSH1
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

158189:SPIBUDDY RS14505
gene id: 158189:SPIBUDDY_RS14505
uniprot id: F0RS75
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

158189:SPIBUDDY RS11650
gene id: 158189:SPIBUDDY_RS11650
uniprot id: F0RSJ9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS14315
gene id: 158189:SPIBUDDY_RS14315
uniprot id: F0RS38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

158189:SPIBUDDY RS08175
gene id: 158189:SPIBUDDY_RS08175
uniprot id: F0RW74
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

158189:SPIBUDDY RS04430
gene id: 158189:SPIBUDDY_RS04430
uniprot id: F0RYD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

158189:SPIBUDDY RS03560
gene id: 158189:SPIBUDDY_RS03560
uniprot id: F0RUV9
names: Subcellular Location Annotation
messages: Membrane

158189:SPIBUDDY RS10540
gene id: 158189:SPIBUDDY_RS10540
uniprot id: F0RTI7
names: Function
names: Similarity
messages: Belongs to the vsr family.
messages: May nick specific sequences that contain T:G mispairs resulting from m5C-deamination.

158189:SPIBUDDY RS07260
gene id: 158189:SPIBUDDY_RS07260
uniprot id: F0RZ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS06680
gene id: 158189:SPIBUDDY_RS06680
uniprot id: F0RVS3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

158189:SPIBUDDY RS08980
gene id: 158189:SPIBUDDY_RS08980
uniprot id: F0RWF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

158189:SPIBUDDY RS10075
gene id: 158189:SPIBUDDY_RS10075
uniprot id: F0RTR4
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.

158189:SPIBUDDY RS04180
gene id: 158189:SPIBUDDY_RS04180
uniprot id: F0RV09
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS10245
gene id: 158189:SPIBUDDY_RS10245
uniprot id: F0RTW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

158189:SPIBUDDY RS14615
gene id: 158189:SPIBUDDY_RS14615
uniprot id: F0RS89
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

158189:SPIBUDDY RS03510
gene id: 158189:SPIBUDDY_RS03510
uniprot id: F0RUU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane