1434110:MSHOH RS05430
gene id: 1434110:MSHOH_RS05430
uniprot id: A0A0E3S9U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434110:MSHOH RS02050
gene id: 1434110:MSHOH_RS02050
uniprot id: A0A0E3SC63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

1434110:MSHOH RS18300
gene id: 1434110:MSHOH_RS18300
uniprot id: A0A0E3SD12
names: Subcellular Location Annotation
messages: Cell membrane

1434110:MSHOH RS01300
gene id: 1434110:MSHOH_RS01300
uniprot id: A0A0E3S837
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1434110:MSHOH RS00745
gene id: 1434110:MSHOH_RS00745
uniprot id: A0A0E3S602
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1434110:MSHOH RS16155
gene id: 1434110:MSHOH_RS16155
uniprot id: A0A0E3SC40
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS13175
gene id: 1434110:MSHOH_RS13175
uniprot id: A0A0E3SH06
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS10970
gene id: 1434110:MSHOH_RS10970
uniprot id: A0A0E3SA62
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS18960
gene id: 1434110:MSHOH_RS18960
uniprot id: A0A0E3SFW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

1434110:MSHOH RS04075
gene id: 1434110:MSHOH_RS04075
uniprot id: A0A0E3S9B2
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS21715
gene id: 1434110:MSHOH_RS21715
uniprot id: A0A0E3SJ25
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS03000
gene id: 1434110:MSHOH_RS03000
uniprot id: A0A0E3S6Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

1434110:MSHOH RS17140
gene id: 1434110:MSHOH_RS17140
uniprot id: A0A0E3SGZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1434110:MSHOH RS02055
gene id: 1434110:MSHOH_RS02055
uniprot id: A0A0E3S6M0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1434110:MSHOH RS06015
gene id: 1434110:MSHOH_RS06015
uniprot id: A0A0E3SA33
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1434110:MSHOH RS13895
gene id: 1434110:MSHOH_RS13895
uniprot id: A0A0E3WW52
names: Similarity
messages: Belongs to the AOR/FOR family.

1434110:MSHOH RS08245
gene id: 1434110:MSHOH_RS08245
uniprot id: A0A0E3SD83
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

1434110:MSHOH RS12935
gene id: 1434110:MSHOH_RS12935
uniprot id: A0A0E3WW17
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS21230
gene id: 1434110:MSHOH_RS21230
uniprot id: A0A0E3SIQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

1434110:MSHOH RS14195
gene id: 1434110:MSHOH_RS14195
uniprot id: A0A0E3SE06
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1434110:MSHOH RS20670
gene id: 1434110:MSHOH_RS20670
uniprot id: A0A0E3SE13
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

1434110:MSHOH RS16200
gene id: 1434110:MSHOH_RS16200
uniprot id: A0A0E3SHY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434110:MSHOH RS02065
gene id: 1434110:MSHOH_RS02065
uniprot id: A0A0E3S8D7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

1434110:MSHOH RS00255
gene id: 1434110:MSHOH_RS00255
uniprot id: A0A0E3SA56
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS04245
gene id: 1434110:MSHOH_RS04245
uniprot id: A0A0E3SBS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

1434110:MSHOH RS04040
gene id: 1434110:MSHOH_RS04040
uniprot id: A0A0E3WT54
names: Subcellular Location Annotation
messages: Cytoplasm

1434110:MSHOH RS17205
gene id: 1434110:MSHOH_RS17205
uniprot id: A0A0E3WWJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1434110:MSHOH RS18565
gene id: 1434110:MSHOH_RS18565
uniprot id: A0A0E3SHI6
names: Similarity
messages: Belongs to the thioesterase PaaI family.

1434110:MSHOH RS05400
gene id: 1434110:MSHOH_RS05400
uniprot id: A0A0E3WSX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

1434110:MSHOH RS20695
gene id: 1434110:MSHOH_RS20695
uniprot id: A0A0E3SE18
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS10870
gene id: 1434110:MSHOH_RS10870
uniprot id: A0A0E3SCE7
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS10880
gene id: 1434110:MSHOH_RS10880
uniprot id: A0A0E3SG80
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1434110:MSHOH RS07035
gene id: 1434110:MSHOH_RS07035
uniprot id: A0A0E3SAI2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

1434110:MSHOH RS08095
gene id: 1434110:MSHOH_RS08095
uniprot id: A0A0E3SD68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane

1434110:MSHOH RS03660
gene id: 1434110:MSHOH_RS03660
uniprot id: A0A0E3WV53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS16255
gene id: 1434110:MSHOH_RS16255
uniprot id: A0A0E3SC54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1434110:MSHOH RS19325
gene id: 1434110:MSHOH_RS19325
uniprot id: A0A0E3SDF9
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

1434110:MSHOH RS13515
gene id: 1434110:MSHOH_RS13515
uniprot id: A0A0E3SB42
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1434110:MSHOH RS20100
gene id: 1434110:MSHOH_RS20100
uniprot id: A0A0E3SGJ1
names: Similarity
messages: Belongs to the LarC family.

1434110:MSHOH RS17710
gene id: 1434110:MSHOH_RS17710
uniprot id: A0A0E3SCV1
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

1434110:MSHOH RS20565
gene id: 1434110:MSHOH_RS20565
uniprot id: A0A0E3WVP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434110:MSHOH RS20335
gene id: 1434110:MSHOH_RS20335
uniprot id: A0A0E3SIF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

1434110:MSHOH RS17380
gene id: 1434110:MSHOH_RS17380
uniprot id: A0A0E3SCM5
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1434110:MSHOH RS04825
gene id: 1434110:MSHOH_RS04825
uniprot id: A0A0E3WU57
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS17230
gene id: 1434110:MSHOH_RS17230
uniprot id: A0A0E3WV03
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1434110:MSHOH RS02290
gene id: 1434110:MSHOH_RS02290
uniprot id: A0A0E3WSZ0
names: Similarity
messages: Belongs to the glutamate synthase family.

1434110:MSHOH RS17795
gene id: 1434110:MSHOH_RS17795
uniprot id: A0A0E3WVH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

1434110:MSHOH RS17595
gene id: 1434110:MSHOH_RS17595
uniprot id: A0A0E3WWL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1434110:MSHOH RS03975
gene id: 1434110:MSHOH_RS03975
uniprot id: A0A0E3WSS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

1434110:MSHOH RS02705
gene id: 1434110:MSHOH_RS02705
uniprot id: A0A0E3WV16
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS21335
gene id: 1434110:MSHOH_RS21335
uniprot id: A0A0E3SJN1
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

1434110:MSHOH RS08545
gene id: 1434110:MSHOH_RS08545
uniprot id: A0A0E3WUH7
names: Similarity
messages: Belongs to the UPF0758 family.

1434110:MSHOH RS00585
gene id: 1434110:MSHOH_RS00585
uniprot id: A0A0E3S7R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

1434110:MSHOH RS18585
gene id: 1434110:MSHOH_RS18585
uniprot id: A0A0E3WVK6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1434110:MSHOH RS11035
gene id: 1434110:MSHOH_RS11035
uniprot id: A0A0E3WTF3
names: Similarity
messages: Belongs to the UPF0210 family.

1434110:MSHOH RS06520
gene id: 1434110:MSHOH_RS06520
uniprot id: A0A0E3S8E3
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

1434110:MSHOH RS06160
gene id: 1434110:MSHOH_RS06160
uniprot id: A0A0E3SDU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434110:MSHOH RS05515
gene id: 1434110:MSHOH_RS05515
uniprot id: A0A0E3WTW7
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

1434110:MSHOH RS01850
gene id: 1434110:MSHOH_RS01850
uniprot id: A0A0E3S8A6
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS04990
gene id: 1434110:MSHOH_RS04990
uniprot id: A0A0E3SC20
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1434110:MSHOH RS05425
gene id: 1434110:MSHOH_RS05425
uniprot id: A0A0E3WU80
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

1434110:MSHOH RS14700
gene id: 1434110:MSHOH_RS14700
uniprot id: A0A0E3SBK6
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS17915
gene id: 1434110:MSHOH_RS17915
uniprot id: A0A0E3SFG5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS03615
gene id: 1434110:MSHOH_RS03615
uniprot id: A0A0E3SBJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS15405
gene id: 1434110:MSHOH_RS15405
uniprot id: A0A0E3SEI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

1434110:MSHOH RS05375
gene id: 1434110:MSHOH_RS05375
uniprot id: A0A0E3WTW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1434110:MSHOH RS03880
gene id: 1434110:MSHOH_RS03880
uniprot id: A0A0E3SBN0
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.

1434110:MSHOH RS04115
gene id: 1434110:MSHOH_RS04115
uniprot id: A0A0E3S7C3
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS08255
gene id: 1434110:MSHOH_RS08255
uniprot id: A0A0E3S929
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

1434110:MSHOH RS14435
gene id: 1434110:MSHOH_RS14435
uniprot id: A0A0E3SBI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1434110:MSHOH RS06195
gene id: 1434110:MSHOH_RS06195
uniprot id: A0A0E3WT05
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434110:MSHOH RS16655
gene id: 1434110:MSHOH_RS16655
uniprot id: A0A0E3SEZ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS20190
gene id: 1434110:MSHOH_RS20190
uniprot id: A0A0E3SJ95
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

1434110:MSHOH RS13180
gene id: 1434110:MSHOH_RS13180
uniprot id: A0A0E3SAZ0
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS13865
gene id: 1434110:MSHOH_RS13865
uniprot id: A0A0E3SB95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

1434110:MSHOH RS12975
gene id: 1434110:MSHOH_RS12975
uniprot id: A0A0E3SGY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS18125
gene id: 1434110:MSHOH_RS18125
uniprot id: A0A0E3SHD6
names: Similarity
messages: Belongs to the archaeal-type GPI family.

1434110:MSHOH RS14225
gene id: 1434110:MSHOH_RS14225
uniprot id: A0A0E3SFT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS19470
gene id: 1434110:MSHOH_RS19470
uniprot id: A0A0E3SG67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

1434110:MSHOH RS21225
gene id: 1434110:MSHOH_RS21225
uniprot id: A0A0E3SGZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

1434110:MSHOH RS05325
gene id: 1434110:MSHOH_RS05325
uniprot id: A0A0E3S9T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

1434110:MSHOH RS17135
gene id: 1434110:MSHOH_RS17135
uniprot id: A0A0E3SF74
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1434110:MSHOH RS15375
gene id: 1434110:MSHOH_RS15375
uniprot id: A0A0E3WUJ8
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS12625
gene id: 1434110:MSHOH_RS12625
uniprot id: A0A0E3SF25
names: Similarity
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.

1434110:MSHOH RS21125
gene id: 1434110:MSHOH_RS21125
uniprot id: A0A0E3SJK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
messages: Cytoplasm

1434110:MSHOH RS01990
gene id: 1434110:MSHOH_RS01990
uniprot id: A0A0E3SAV6
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

1434110:MSHOH RS08215
gene id: 1434110:MSHOH_RS08215
uniprot id: A0A0E3SD81
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS00215
gene id: 1434110:MSHOH_RS00215
uniprot id: A0A0E3S5S0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1434110:MSHOH RS03560
gene id: 1434110:MSHOH_RS03560
uniprot id: A0A0E3SBH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS01675
gene id: 1434110:MSHOH_RS01675
uniprot id: A0A0E3S6G3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS03700
gene id: 1434110:MSHOH_RS03700
uniprot id: A0A0E3S764
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

1434110:MSHOH RS16720
gene id: 1434110:MSHOH_RS16720
uniprot id: A0A0E3SCB7
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1434110:MSHOH RS20420
gene id: 1434110:MSHOH_RS20420
uniprot id: A0A0E3SDY1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS12350
gene id: 1434110:MSHOH_RS12350
uniprot id: A0A0E3SGS6
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

1434110:MSHOH RS07980
gene id: 1434110:MSHOH_RS07980
uniprot id: A0A0E3SD58
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1434110:MSHOH RS06165
gene id: 1434110:MSHOH_RS06165
uniprot id: A0A0E3S865
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS10945
gene id: 1434110:MSHOH_RS10945
uniprot id: A0A0E3SA58
names: Similarity
messages: Belongs to the TlyA family.

1434110:MSHOH RS11765
gene id: 1434110:MSHOH_RS11765
uniprot id: A0A0E3SGK8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS10920
gene id: 1434110:MSHOH_RS10920
uniprot id: A0A0E3WUQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1434110:MSHOH RS09060
gene id: 1434110:MSHOH_RS09060
uniprot id: A0A0E3S9E9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

1434110:MSHOH RS14410
gene id: 1434110:MSHOH_RS14410
uniprot id: A0A0E3SBH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

1434110:MSHOH RS15110
gene id: 1434110:MSHOH_RS15110
uniprot id: A0A0E3SHL7
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS17060
gene id: 1434110:MSHOH_RS17060
uniprot id: A0A0E3SCI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1434110:MSHOH RS00550
gene id: 1434110:MSHOH_RS00550
uniprot id: A0A0E3S5X2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1434110:MSHOH RS15900
gene id: 1434110:MSHOH_RS15900
uniprot id: A0A0E3SEP9
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1434110:MSHOH RS03825
gene id: 1434110:MSHOH_RS03825
uniprot id: A0A0E3S990
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1434110:MSHOH RS15905
gene id: 1434110:MSHOH_RS15905
uniprot id: A0A0E3SGG4
names: Similarity
messages: Belongs to the UPF0212 family.

1434110:MSHOH RS09650
gene id: 1434110:MSHOH_RS09650
uniprot id: A0A0E3SDU8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434110:MSHOH RS17190
gene id: 1434110:MSHOH_RS17190
uniprot id: A0A0E3SH09
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

1434110:MSHOH RS20280
gene id: 1434110:MSHOH_RS20280
uniprot id: A0A0E3SGM4
names: Subcellular Location Annotation
messages: Cell membrane

1434110:MSHOH RS01785
gene id: 1434110:MSHOH_RS01785
uniprot id: A0A0E3S899
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1434110:MSHOH RS08855
gene id: 1434110:MSHOH_RS08855
uniprot id: A0A0E3WVN2
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1434110:MSHOH RS02845
gene id: 1434110:MSHOH_RS02845
uniprot id: A0A0E3WV21
names: Similarity
messages: Belongs to the AAA ATPase family.

1434110:MSHOH RS22340
gene id: 1434110:MSHOH_RS22340
uniprot id: A0A0E3SEW3
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1434110:MSHOH RS20225
gene id: 1434110:MSHOH_RS20225
uniprot id: A0A0E3WWU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

1434110:MSHOH RS21380
gene id: 1434110:MSHOH_RS21380
uniprot id: A0A0E3SIV3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

1434110:MSHOH RS02040
gene id: 1434110:MSHOH_RS02040
uniprot id: A0A0E3S8D3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1434110:MSHOH RS20405
gene id: 1434110:MSHOH_RS20405
uniprot id: A0A0E3SGP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS03930
gene id: 1434110:MSHOH_RS03930
uniprot id: A0A0E3SBN8
names: Similarity
messages: Belongs to the UPF0285 family.

1434110:MSHOH RS05795
gene id: 1434110:MSHOH_RS05795
uniprot id: A0A0E3SCC4
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS04505
gene id: 1434110:MSHOH_RS04505
uniprot id: A0A0E3SBV8
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

1434110:MSHOH RS17055
gene id: 1434110:MSHOH_RS17055
uniprot id: A0A0E3SIB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1434110:MSHOH RS02265
gene id: 1434110:MSHOH_RS02265
uniprot id: A0A0E3WTZ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS01295
gene id: 1434110:MSHOH_RS01295
uniprot id: A0A0E3WTL1
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

1434110:MSHOH RS20180
gene id: 1434110:MSHOH_RS20180
uniprot id: A0A0E3SGK3
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS02620
gene id: 1434110:MSHOH_RS02620
uniprot id: A0A0E3WSM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

1434110:MSHOH RS03090
gene id: 1434110:MSHOH_RS03090
uniprot id: A0A0E3WT16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1434110:MSHOH RS21660
gene id: 1434110:MSHOH_RS21660
uniprot id: A0A0E3SJ19
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

1434110:MSHOH RS05395
gene id: 1434110:MSHOH_RS05395
uniprot id: A0A0E3S7X2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

1434110:MSHOH RS02150
gene id: 1434110:MSHOH_RS02150
uniprot id: A0A0E3SAX9
names: Similarity
messages: Belongs to the UPF0251 family.

1434110:MSHOH RS08025
gene id: 1434110:MSHOH_RS08025
uniprot id: A0A0E3WUG3
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1434110:MSHOH RS00460
gene id: 1434110:MSHOH_RS00460
uniprot id: A0A0E3SA85
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1434110:MSHOH RS11280
gene id: 1434110:MSHOH_RS11280
uniprot id: A0A0E3SEJ5
names: Similarity
messages: Belongs to the ATPase gamma chain family.

1434110:MSHOH RS09480
gene id: 1434110:MSHOH_RS09480
uniprot id: A0A0E3S9L0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

1434110:MSHOH RS09565
gene id: 1434110:MSHOH_RS09565
uniprot id: A0A0E3SDT7
names: Similarity
messages: Belongs to the HdrC family.

1434110:MSHOH RS02545
gene id: 1434110:MSHOH_RS02545
uniprot id: A0A0E3WT00
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS17770
gene id: 1434110:MSHOH_RS17770
uniprot id: A0A0E3WU86
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

1434110:MSHOH RS06595
gene id: 1434110:MSHOH_RS06595
uniprot id: A0A0E3SE38
names: Similarity
messages: Belongs to the MtxX family.

1434110:MSHOH RS17240
gene id: 1434110:MSHOH_RS17240
uniprot id: A0A0E3SH16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

1434110:MSHOH RS11150
gene id: 1434110:MSHOH_RS11150
uniprot id: A0A0E3SA82
names: Similarity
messages: Belongs to the UPF0677 family.

1434110:MSHOH RS09030
gene id: 1434110:MSHOH_RS09030
uniprot id: A0A0E3SFD2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS05045
gene id: 1434110:MSHOH_RS05045
uniprot id: A0A0E3S7Q9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1434110:MSHOH RS00580
gene id: 1434110:MSHOH_RS00580
uniprot id: A0A0E3WTP1
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

1434110:MSHOH RS13035
gene id: 1434110:MSHOH_RS13035
uniprot id: A0A0E3SAX2
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1434110:MSHOH RS11305
gene id: 1434110:MSHOH_RS11305
uniprot id: A0A0E3WTG2
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

1434110:MSHOH RS14475
gene id: 1434110:MSHOH_RS14475
uniprot id: A0A0E3SFZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

1434110:MSHOH RS07635
gene id: 1434110:MSHOH_RS07635
uniprot id: A0A0E3WTI4
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

1434110:MSHOH RS00355
gene id: 1434110:MSHOH_RS00355
uniprot id: A0A0E3WSI6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1434110:MSHOH RS14965
gene id: 1434110:MSHOH_RS14965
uniprot id: A0A0E3SHK3
names: Similarity
messages: Belongs to the PspA/IM30 family.

1434110:MSHOH RS10830
gene id: 1434110:MSHOH_RS10830
uniprot id: A0A0E3SG62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

1434110:MSHOH RS08160
gene id: 1434110:MSHOH_RS08160
uniprot id: A0A0E3SD76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1434110:MSHOH RS10525
gene id: 1434110:MSHOH_RS10525
uniprot id: A0A0E3WUP3
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1434110:MSHOH RS01635
gene id: 1434110:MSHOH_RS01635
uniprot id: A0A0E3WST5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS19800
gene id: 1434110:MSHOH_RS19800
uniprot id: A0A0E3SDP1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

1434110:MSHOH RS02095
gene id: 1434110:MSHOH_RS02095
uniprot id: A0A0E3S8E1
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

1434110:MSHOH RS06025
gene id: 1434110:MSHOH_RS06025
uniprot id: A0A0E3SDR7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1434110:MSHOH RS13745
gene id: 1434110:MSHOH_RS13745
uniprot id: A0A0E3SH78
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1434110:MSHOH RS20580
gene id: 1434110:MSHOH_RS20580
uniprot id: A0A0E3SJD6
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

1434110:MSHOH RS21800
gene id: 1434110:MSHOH_RS21800
uniprot id: A0A0E3SJ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1434110:MSHOH RS05570
gene id: 1434110:MSHOH_RS05570
uniprot id: A0A0E3WU85
names: Similarity
messages: Belongs to the UPF0228 family.

1434110:MSHOH RS14595
gene id: 1434110:MSHOH_RS14595
uniprot id: A0A0E3WW76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434110:MSHOH RS04705
gene id: 1434110:MSHOH_RS04705
uniprot id: A0A0E3S7K0
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS21655
gene id: 1434110:MSHOH_RS21655
uniprot id: A0A0E3SH47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

1434110:MSHOH RS10835
gene id: 1434110:MSHOH_RS10835
uniprot id: A0A0E3SA42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

1434110:MSHOH RS07215
gene id: 1434110:MSHOH_RS07215
uniprot id: A0A0E3S8N6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS00365
gene id: 1434110:MSHOH_RS00365
uniprot id: A0A0E3SA71
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS20805
gene id: 1434110:MSHOH_RS20805
uniprot id: A0A0E3WUI2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1434110:MSHOH RS20095
gene id: 1434110:MSHOH_RS20095
uniprot id: A0A0E3WWT9
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

1434110:MSHOH RS18100
gene id: 1434110:MSHOH_RS18100
uniprot id: A0A0E3SHD3
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1434110:MSHOH RS10255
gene id: 1434110:MSHOH_RS10255
uniprot id: A0A0E3S9W3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1434110:MSHOH RS19035
gene id: 1434110:MSHOH_RS19035
uniprot id: A0A0E3WWR0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

1434110:MSHOH RS06030
gene id: 1434110:MSHOH_RS06030
uniprot id: A0A0E3S850
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1434110:MSHOH RS14920
gene id: 1434110:MSHOH_RS14920
uniprot id: A0A0E3SBN9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

1434110:MSHOH RS12985
gene id: 1434110:MSHOH_RS12985
uniprot id: A0A0E3WTM0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS21220
gene id: 1434110:MSHOH_RS21220
uniprot id: A0A0E3WVR2
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

1434110:MSHOH RS06380
gene id: 1434110:MSHOH_RS06380
uniprot id: A0A0E3SAA6
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1434110:MSHOH RS21710
gene id: 1434110:MSHOH_RS21710
uniprot id: A0A0E3SH56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

1434110:MSHOH RS17445
gene id: 1434110:MSHOH_RS17445
uniprot id: A0A0E3SH42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex.

1434110:MSHOH RS14380
gene id: 1434110:MSHOH_RS14380
uniprot id: A0A0E3SFV6
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

1434110:MSHOH RS18460
gene id: 1434110:MSHOH_RS18460
uniprot id: A0A0E3SHG0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

1434110:MSHOH RS14995
gene id: 1434110:MSHOH_RS14995
uniprot id: A0A0E3SBP9
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

1434110:MSHOH RS19010
gene id: 1434110:MSHOH_RS19010
uniprot id: A0A0E3SFX5
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1434110:MSHOH RS07555
gene id: 1434110:MSHOH_RS07555
uniprot id: A0A0E3SAQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

1434110:MSHOH RS18805
gene id: 1434110:MSHOH_RS18805
uniprot id: A0A0E3SFU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS21000
gene id: 1434110:MSHOH_RS21000
uniprot id: A0A0E3SIM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1434110:MSHOH RS19375
gene id: 1434110:MSHOH_RS19375
uniprot id: A0A0E3SIZ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434110:MSHOH RS14675
gene id: 1434110:MSHOH_RS14675
uniprot id: A0A0E3SBK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

1434110:MSHOH RS14590
gene id: 1434110:MSHOH_RS14590
uniprot id: A0A0E3SBJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434110:MSHOH RS20870
gene id: 1434110:MSHOH_RS20870
uniprot id: A0A0E3SGV8
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

1434110:MSHOH RS03770
gene id: 1434110:MSHOH_RS03770
uniprot id: A0A0E3WT43
names: Similarity
messages: Belongs to the UPF0284 family.

1434110:MSHOH RS01280
gene id: 1434110:MSHOH_RS01280
uniprot id: A0A0E3SAN4
names: Similarity
messages: Belongs to the thymidylate kinase family.

1434110:MSHOH RS03990
gene id: 1434110:MSHOH_RS03990
uniprot id: A0A0E3SD06
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS15915
gene id: 1434110:MSHOH_RS15915
uniprot id: A0A0E3SC13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

1434110:MSHOH RS17170
gene id: 1434110:MSHOH_RS17170
uniprot id: A0A0E3SIC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1434110:MSHOH RS12440
gene id: 1434110:MSHOH_RS12440
uniprot id: A0A0E3SAQ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS10515
gene id: 1434110:MSHOH_RS10515
uniprot id: A0A0E3SFZ7
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

1434110:MSHOH RS19150
gene id: 1434110:MSHOH_RS19150
uniprot id: A0A0E3SHU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1434110:MSHOH RS16585
gene id: 1434110:MSHOH_RS16585
uniprot id: A0A0E3SI43
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS21685
gene id: 1434110:MSHOH_RS21685
uniprot id: A0A0E3SJ23
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

1434110:MSHOH RS00600
gene id: 1434110:MSHOH_RS00600
uniprot id: A0A0E3WSJ3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1434110:MSHOH RS08385
gene id: 1434110:MSHOH_RS08385
uniprot id: A0A0E3S945
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS04745
gene id: 1434110:MSHOH_RS04745
uniprot id: A0A0E3WV82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

1434110:MSHOH RS19715
gene id: 1434110:MSHOH_RS19715
uniprot id: A0A0E3SDM8
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

1434110:MSHOH RS09925
gene id: 1434110:MSHOH_RS09925
uniprot id: A0A0E3SBW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1434110:MSHOH RS21650
gene id: 1434110:MSHOH_RS21650
uniprot id: A0A0E3WV70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1434110:MSHOH RS02000
gene id: 1434110:MSHOH_RS02000
uniprot id: A0A0E3S6L1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1434110:MSHOH RS16875
gene id: 1434110:MSHOH_RS16875
uniprot id: A0A0E3SI86
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

1434110:MSHOH RS01510
gene id: 1434110:MSHOH_RS01510
uniprot id: A0A0E3S864
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434110:MSHOH RS20535
gene id: 1434110:MSHOH_RS20535
uniprot id: A0A0E3SDZ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434110:MSHOH RS10510
gene id: 1434110:MSHOH_RS10510
uniprot id: A0A0E3SE64
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

1434110:MSHOH RS03100
gene id: 1434110:MSHOH_RS03100
uniprot id: A0A0E3SBC2
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

1434110:MSHOH RS10120
gene id: 1434110:MSHOH_RS10120
uniprot id: A0A0E3SFT7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1434110:MSHOH RS20540
gene id: 1434110:MSHOH_RS20540
uniprot id: A0A0E3WUH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434110:MSHOH RS06345
gene id: 1434110:MSHOH_RS06345
uniprot id: A0A0E3S8B5
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

1434110:MSHOH RS15215
gene id: 1434110:MSHOH_RS15215
uniprot id: A0A0E3SBS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1434110:MSHOH RS02190
gene id: 1434110:MSHOH_RS02190
uniprot id: A0A0E3WUZ5
names: Similarity
messages: Belongs to the HdrB family.

1434110:MSHOH RS13585
gene id: 1434110:MSHOH_RS13585
uniprot id: A0A0E3SFK1
names: Similarity
messages: Belongs to the HerA family.

1434110:MSHOH RS00420
gene id: 1434110:MSHOH_RS00420
uniprot id: A0A0E3S5V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

1434110:MSHOH RS12855
gene id: 1434110:MSHOH_RS12855
uniprot id: A0A0E3WTL4
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS10560
gene id: 1434110:MSHOH_RS10560
uniprot id: A0A0E3SC98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434110:MSHOH RS12945
gene id: 1434110:MSHOH_RS12945
uniprot id: A0A0E3SF68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1434110:MSHOH RS00200
gene id: 1434110:MSHOH_RS00200
uniprot id: A0A0E3SB82
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS19145
gene id: 1434110:MSHOH_RS19145
uniprot id: A0A0E3SFZ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1434110:MSHOH RS01680
gene id: 1434110:MSHOH_RS01680
uniprot id: A0A0E3WTQ2
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS20590
gene id: 1434110:MSHOH_RS20590
uniprot id: A0A0E3WV36
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1434110:MSHOH RS04025
gene id: 1434110:MSHOH_RS04025
uniprot id: A0A0E3SD10
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

1434110:MSHOH RS05215
gene id: 1434110:MSHOH_RS05215
uniprot id: A0A0E3SC43
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS20995
gene id: 1434110:MSHOH_RS20995
uniprot id: A0A0E3SGX4
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

1434110:MSHOH RS06545
gene id: 1434110:MSHOH_RS06545
uniprot id: A0A0E3S8E8
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS08365
gene id: 1434110:MSHOH_RS08365
uniprot id: A0A0E3WU22
names: Similarity
messages: Belongs to the glutamine synthetase family.

1434110:MSHOH RS21035
gene id: 1434110:MSHOH_RS21035
uniprot id: A0A0E3WVD4
names: Similarity
messages: Belongs to the UPF0677 family.

1434110:MSHOH RS04770
gene id: 1434110:MSHOH_RS04770
uniprot id: A0A0E3S7L3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

1434110:MSHOH RS21785
gene id: 1434110:MSHOH_RS21785
uniprot id: A0A0E3SEH4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS23050
gene id: 1434110:MSHOH_RS23050
uniprot id: A0A0E3WUW9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

1434110:MSHOH RS06640
gene id: 1434110:MSHOH_RS06640
uniprot id: A0A0E3SAE0
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

1434110:MSHOH RS03775
gene id: 1434110:MSHOH_RS03775
uniprot id: A0A0E3S981
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1434110:MSHOH RS14740
gene id: 1434110:MSHOH_RS14740
uniprot id: A0A0E3SG23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS08620
gene id: 1434110:MSHOH_RS08620
uniprot id: A0A0E3S973
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

1434110:MSHOH RS17855
gene id: 1434110:MSHOH_RS17855
uniprot id: A0A0E3SCV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1434110:MSHOH RS20795
gene id: 1434110:MSHOH_RS20795
uniprot id: A0A0E3SJG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1434110:MSHOH RS16345
gene id: 1434110:MSHOH_RS16345
uniprot id: A0A0E3SGN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

1434110:MSHOH RS08395
gene id: 1434110:MSHOH_RS08395
uniprot id: A0A0E3SB48
names: Subcellular Location Annotation
messages: Periplasm

1434110:MSHOH RS15990
gene id: 1434110:MSHOH_RS15990
uniprot id: A0A0E3WVB3
names: Similarity
messages: Belongs to the TPP enzyme family.

1434110:MSHOH RS10750
gene id: 1434110:MSHOH_RS10750
uniprot id: A0A0E3SEA4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS01480
gene id: 1434110:MSHOH_RS01480
uniprot id: A0A0E3S6D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

1434110:MSHOH RS18720
gene id: 1434110:MSHOH_RS18720
uniprot id: A0A0E3WVL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

1434110:MSHOH RS17845
gene id: 1434110:MSHOH_RS17845
uniprot id: A0A0E3SHA1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS16400
gene id: 1434110:MSHOH_RS16400
uniprot id: A0A0E3SI16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

1434110:MSHOH RS16700
gene id: 1434110:MSHOH_RS16700
uniprot id: A0A0E3WUY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1434110:MSHOH RS00940
gene id: 1434110:MSHOH_RS00940
uniprot id: A0A0E3WSB8
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS12420
gene id: 1434110:MSHOH_RS12420
uniprot id: A0A0E3SDB2
names: Similarity
messages: Belongs to the pirin family.

1434110:MSHOH RS00005
gene id: 1434110:MSHOH_RS00005
uniprot id: A0A0E3S5P4
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1434110:MSHOH RS00470
gene id: 1434110:MSHOH_RS00470
uniprot id: A0A0E3S5W2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1434110:MSHOH RS15305
gene id: 1434110:MSHOH_RS15305
uniprot id: A0A0E3SEH3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

1434110:MSHOH RS14200
gene id: 1434110:MSHOH_RS14200
uniprot id: A0A0E3SFT0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1434110:MSHOH RS09000
gene id: 1434110:MSHOH_RS09000
uniprot id: A0A0E3SDK2
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1434110:MSHOH RS15370
gene id: 1434110:MSHOH_RS15370
uniprot id: A0A0E3SBU5
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS10605
gene id: 1434110:MSHOH_RS10605
uniprot id: A0A0E3SA10
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1434110:MSHOH RS05225
gene id: 1434110:MSHOH_RS05225
uniprot id: A0A0E3S7U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS08360
gene id: 1434110:MSHOH_RS08360
uniprot id: A0A0E3S942
names: Similarity
messages: Belongs to the UPF0145 family.

1434110:MSHOH RS11260
gene id: 1434110:MSHOH_RS11260
uniprot id: A0A0E3SGC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane

1434110:MSHOH RS05150
gene id: 1434110:MSHOH_RS05150
uniprot id: A0A0E3SC36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

1434110:MSHOH RS05530
gene id: 1434110:MSHOH_RS05530
uniprot id: A0A0E3SDJ3
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

1434110:MSHOH RS21265
gene id: 1434110:MSHOH_RS21265
uniprot id: A0A0E3SJM3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1434110:MSHOH RS03055
gene id: 1434110:MSHOH_RS03055
uniprot id: A0A0E3S6Z7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS13640
gene id: 1434110:MSHOH_RS13640
uniprot id: A0A0E3SH60
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

1434110:MSHOH RS03980
gene id: 1434110:MSHOH_RS03980
uniprot id: A0A0E3S9A6
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

1434110:MSHOH RS20690
gene id: 1434110:MSHOH_RS20690
uniprot id: A0A0E3SJF0
names: Similarity
messages: Belongs to the UPF0107 family.

1434110:MSHOH RS09305
gene id: 1434110:MSHOH_RS09305
uniprot id: A0A0E3SDP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Membrane

1434110:MSHOH RS16425
gene id: 1434110:MSHOH_RS16425
uniprot id: A0A0E3SI21
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1434110:MSHOH RS16285
gene id: 1434110:MSHOH_RS16285
uniprot id: A0A0E3WWG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Homodimer.

1434110:MSHOH RS07245
gene id: 1434110:MSHOH_RS07245
uniprot id: A0A0E3S8N9
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS15210
gene id: 1434110:MSHOH_RS15210
uniprot id: A0A0E3SHM7
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS17180
gene id: 1434110:MSHOH_RS17180
uniprot id: A0A0E3WUR4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

1434110:MSHOH RS09875
gene id: 1434110:MSHOH_RS09875
uniprot id: A0A0E3SBV2
names: Similarity
messages: Belongs to the TPP enzyme family.

1434110:MSHOH RS04185
gene id: 1434110:MSHOH_RS04185
uniprot id: A0A0E3SBS0
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

1434110:MSHOH RS11720
gene id: 1434110:MSHOH_RS11720
uniprot id: A0A0E3SAG5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS09795
gene id: 1434110:MSHOH_RS09795
uniprot id: A0A0E3WVS0
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

1434110:MSHOH RS01900
gene id: 1434110:MSHOH_RS01900
uniprot id: A0A0E3WSX3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1434110:MSHOH RS17910
gene id: 1434110:MSHOH_RS17910
uniprot id: A0A0E3WU92
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS19345
gene id: 1434110:MSHOH_RS19345
uniprot id: A0A0E3SIZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

1434110:MSHOH RS19065
gene id: 1434110:MSHOH_RS19065
uniprot id: A0A0E3SFY4
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

1434110:MSHOH RS06585
gene id: 1434110:MSHOH_RS06585
uniprot id: A0A0E3SAD3
names: Similarity
messages: Belongs to the MtrH family.

1434110:MSHOH RS00610
gene id: 1434110:MSHOH_RS00610
uniprot id: A0A0E3SAA8
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

1434110:MSHOH RS16505
gene id: 1434110:MSHOH_RS16505
uniprot id: A0A0E3SGQ7
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

1434110:MSHOH RS14910
gene id: 1434110:MSHOH_RS14910
uniprot id: A0A0E3SG53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

1434110:MSHOH RS09525
gene id: 1434110:MSHOH_RS09525
uniprot id: A0A0E3S9L7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

1434110:MSHOH RS02590
gene id: 1434110:MSHOH_RS02590
uniprot id: A0A0E3S6T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

1434110:MSHOH RS21050
gene id: 1434110:MSHOH_RS21050
uniprot id: A0A0E3SJJ6
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS05270
gene id: 1434110:MSHOH_RS05270
uniprot id: A0A0E3S7V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS00010
gene id: 1434110:MSHOH_RS00010
uniprot id: A0A0E3WS89
names: Similarity
messages: Belongs to the UPF0200 family.

1434110:MSHOH RS06645
gene id: 1434110:MSHOH_RS06645
uniprot id: A0A0E3SCQ7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1434110:MSHOH RS16395
gene id: 1434110:MSHOH_RS16395
uniprot id: A0A0E3SGN9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS11100
gene id: 1434110:MSHOH_RS11100
uniprot id: A0A0E3SA76
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

1434110:MSHOH RS10115
gene id: 1434110:MSHOH_RS10115
uniprot id: A0A0E3SE08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1434110:MSHOH RS11570
gene id: 1434110:MSHOH_RS11570
uniprot id: A0A0E3SAD0
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS05995
gene id: 1434110:MSHOH_RS05995
uniprot id: A0A0E3SCF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

1434110:MSHOH RS08105
gene id: 1434110:MSHOH_RS08105
uniprot id: A0A0E3S914
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS03230
gene id: 1434110:MSHOH_RS03230
uniprot id: A0A0E3WT23
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1434110:MSHOH RS05220
gene id: 1434110:MSHOH_RS05220
uniprot id: A0A0E3SDF8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS15105
gene id: 1434110:MSHOH_RS15105
uniprot id: A0A0E3SG68
names: Function
messages: Part of a potassium transport system.

1434110:MSHOH RS15540
gene id: 1434110:MSHOH_RS15540
uniprot id: A0A0E3SEK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

1434110:MSHOH RS01100
gene id: 1434110:MSHOH_RS01100
uniprot id: A0A0E3SAK7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

1434110:MSHOH RS21790
gene id: 1434110:MSHOH_RS21790
uniprot id: A0A0E3WWY7
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

1434110:MSHOH RS16515
gene id: 1434110:MSHOH_RS16515
uniprot id: A0A0E3SC82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1434110:MSHOH RS17160
gene id: 1434110:MSHOH_RS17160
uniprot id: A0A0E3SF78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1434110:MSHOH RS17455
gene id: 1434110:MSHOH_RS17455
uniprot id: A0A0E3SCN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

1434110:MSHOH RS12905
gene id: 1434110:MSHOH_RS12905
uniprot id: A0A0E3SAU5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS19480
gene id: 1434110:MSHOH_RS19480
uniprot id: A0A0E3SJ04
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1434110:MSHOH RS20505
gene id: 1434110:MSHOH_RS20505
uniprot id: A0A0E3SJC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ModE family.
messages: Membrane

1434110:MSHOH RS05535
gene id: 1434110:MSHOH_RS05535
uniprot id: A0A0E3S7Y4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS06290
gene id: 1434110:MSHOH_RS06290
uniprot id: A0A0E3SDY9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS06570
gene id: 1434110:MSHOH_RS06570
uniprot id: A0A0E3S8F0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS14715
gene id: 1434110:MSHOH_RS14715
uniprot id: A0A0E3SG19
names: Similarity
messages: Belongs to the DtxR/MntR family.

1434110:MSHOH RS14685
gene id: 1434110:MSHOH_RS14685
uniprot id: A0A0E3SE94
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1434110:MSHOH RS21925
gene id: 1434110:MSHOH_RS21925
uniprot id: A0A0E3S7M7
names: Similarity
messages: Belongs to the UPF0677 family.

1434110:MSHOH RS02820
gene id: 1434110:MSHOH_RS02820
uniprot id: A0A0E3S8Q8
names: Similarity
messages: Belongs to the SUI1 family.

1434110:MSHOH RS15925
gene id: 1434110:MSHOH_RS15925
uniprot id: A0A0E3SEQ0
names: Subcellular Location Annotation
messages: Cytoplasm

1434110:MSHOH RS03050
gene id: 1434110:MSHOH_RS03050
uniprot id: A0A0E3SCL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1434110:MSHOH RS18490
gene id: 1434110:MSHOH_RS18490
uniprot id: A0A0E3SIR7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

1434110:MSHOH RS18735
gene id: 1434110:MSHOH_RS18735
uniprot id: A0A0E3SIU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1434110:MSHOH RS19385
gene id: 1434110:MSHOH_RS19385
uniprot id: A0A0E3WVN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1434110:MSHOH RS06175
gene id: 1434110:MSHOH_RS06175
uniprot id: A0A0E3SA55
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS20475
gene id: 1434110:MSHOH_RS20475
uniprot id: A0A0E3SIG9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1434110:MSHOH RS05510
gene id: 1434110:MSHOH_RS05510
uniprot id: A0A0E3S7Y2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

1434110:MSHOH RS18580
gene id: 1434110:MSHOH_RS18580
uniprot id: A0A0E3SD48
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

1434110:MSHOH RS07415
gene id: 1434110:MSHOH_RS07415
uniprot id: A0A0E3SEE4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the threonine synthase family. Cysteate synthase subfamily.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate.

1434110:MSHOH RS14800
gene id: 1434110:MSHOH_RS14800
uniprot id: A0A0E3SHI5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

1434110:MSHOH RS19565
gene id: 1434110:MSHOH_RS19565
uniprot id: A0A0E3SJ14
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS09285
gene id: 1434110:MSHOH_RS09285
uniprot id: A0A0E3SFG4
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS15400
gene id: 1434110:MSHOH_RS15400
uniprot id: A0A0E3WWD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

1434110:MSHOH RS21345
gene id: 1434110:MSHOH_RS21345
uniprot id: A0A0E3WVR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

1434110:MSHOH RS20245
gene id: 1434110:MSHOH_RS20245
uniprot id: A0A0E3SDW0
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

1434110:MSHOH RS03445
gene id: 1434110:MSHOH_RS03445
uniprot id: A0A0E3WSQ6
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1434110:MSHOH RS04765
gene id: 1434110:MSHOH_RS04765
uniprot id: A0A0E3SD91
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

1434110:MSHOH RS01265
gene id: 1434110:MSHOH_RS01265
uniprot id: A0A0E3S698
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

1434110:MSHOH RS05165
gene id: 1434110:MSHOH_RS05165
uniprot id: A0A0E3WSW1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

1434110:MSHOH RS05195
gene id: 1434110:MSHOH_RS05195
uniprot id: A0A0E3SDF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1434110:MSHOH RS20710
gene id: 1434110:MSHOH_RS20710
uniprot id: A0A0E3SIJ8
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

1434110:MSHOH RS02060
gene id: 1434110:MSHOH_RS02060
uniprot id: A0A0E3WUZ0
names: Similarity
messages: Belongs to the UPF0215 family.

1434110:MSHOH RS01745
gene id: 1434110:MSHOH_RS01745
uniprot id: A0A0E3SC01
names: Similarity
messages: Belongs to the alkaline phosphatase family.

1434110:MSHOH RS17460
gene id: 1434110:MSHOH_RS17460
uniprot id: A0A0E3WWK4
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

1434110:MSHOH RS15145
gene id: 1434110:MSHOH_RS15145
uniprot id: A0A0E3WWC8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

1434110:MSHOH RS03675
gene id: 1434110:MSHOH_RS03675
uniprot id: A0A0E3S760
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS17425
gene id: 1434110:MSHOH_RS17425
uniprot id: A0A0E3SIF5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

1434110:MSHOH RS08535
gene id: 1434110:MSHOH_RS08535
uniprot id: A0A0E3SF45
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1434110:MSHOH RS03680
gene id: 1434110:MSHOH_RS03680
uniprot id: A0A0E3WTU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS17130
gene id: 1434110:MSHOH_RS17130
uniprot id: A0A0E3WU64
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1434110:MSHOH RS20005
gene id: 1434110:MSHOH_RS20005
uniprot id: A0A0E3SJ82
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434110:MSHOH RS15545
gene id: 1434110:MSHOH_RS15545
uniprot id: A0A0E3SGB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

1434110:MSHOH RS19975
gene id: 1434110:MSHOH_RS19975
uniprot id: A0A0E3SJ78
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434110:MSHOH RS02615
gene id: 1434110:MSHOH_RS02615
uniprot id: A0A0E3S6U1
names: Similarity
messages: Belongs to the PurH family.

1434110:MSHOH RS06425
gene id: 1434110:MSHOH_RS06425
uniprot id: A0A0E3WTY1
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS19795
gene id: 1434110:MSHOH_RS19795
uniprot id: A0A0E3SJ56
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

1434110:MSHOH RS02375
gene id: 1434110:MSHOH_RS02375
uniprot id: A0A0E3SB17
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1434110:MSHOH RS14420
gene id: 1434110:MSHOH_RS14420
uniprot id: A0A0E3SE58
names: Similarity
messages: Belongs to the SDO1/SBDS family.

1434110:MSHOH RS14655
gene id: 1434110:MSHOH_RS14655
uniprot id: A0A0E3SE90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

1434110:MSHOH RS17430
gene id: 1434110:MSHOH_RS17430
uniprot id: A0A0E3S997
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

1434110:MSHOH RS02100
gene id: 1434110:MSHOH_RS02100
uniprot id: A0A0E3SAX0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1434110:MSHOH RS18550
gene id: 1434110:MSHOH_RS18550
uniprot id: A0A0E3SD45
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS01585
gene id: 1434110:MSHOH_RS01585
uniprot id: A0A0E3S6E5
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS14445
gene id: 1434110:MSHOH_RS14445
uniprot id: A0A0E3SE65
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

1434110:MSHOH RS20170
gene id: 1434110:MSHOH_RS20170
uniprot id: A0A0E3SDV0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS03960
gene id: 1434110:MSHOH_RS03960
uniprot id: A0A0E3SBP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1434110:MSHOH RS00225
gene id: 1434110:MSHOH_RS00225
uniprot id: A0A0E3S7L1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1434110:MSHOH RS05315
gene id: 1434110:MSHOH_RS05315
uniprot id: A0A0E3S7W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS20730
gene id: 1434110:MSHOH_RS20730
uniprot id: A0A0E3SGU2
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1434110:MSHOH RS16245
gene id: 1434110:MSHOH_RS16245
uniprot id: A0A0E3SGL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1434110:MSHOH RS02645
gene id: 1434110:MSHOH_RS02645
uniprot id: A0A0E3WTZ8
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS08285
gene id: 1434110:MSHOH_RS08285
uniprot id: A0A0E3SD89
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS21360
gene id: 1434110:MSHOH_RS21360
uniprot id: A0A0E3SJN5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS17735
gene id: 1434110:MSHOH_RS17735
uniprot id: A0A0E3SCV2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1434110:MSHOH RS16335
gene id: 1434110:MSHOH_RS16335
uniprot id: A0A0E3SEV1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1434110:MSHOH RS18305
gene id: 1434110:MSHOH_RS18305
uniprot id: A0A0E3WUA6
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

1434110:MSHOH RS06375
gene id: 1434110:MSHOH_RS06375
uniprot id: A0A0E3WTE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1434110:MSHOH RS04315
gene id: 1434110:MSHOH_RS04315
uniprot id: A0A0E3S9D2
names: Similarity
messages: Belongs to the NAD synthetase family.

1434110:MSHOH RS08860
gene id: 1434110:MSHOH_RS08860
uniprot id: A0A0E3SBC5
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

1434110:MSHOH RS19350
gene id: 1434110:MSHOH_RS19350
uniprot id: A0A0E3SDG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

1434110:MSHOH RS17580
gene id: 1434110:MSHOH_RS17580
uniprot id: A0A0E3SH62
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

1434110:MSHOH RS02385
gene id: 1434110:MSHOH_RS02385
uniprot id: A0A0E3S6Q6
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

1434110:MSHOH RS14730
gene id: 1434110:MSHOH_RS14730
uniprot id: A0A0E3WW80
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS12190
gene id: 1434110:MSHOH_RS12190
uniprot id: A0A0E3SCY9
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS21465
gene id: 1434110:MSHOH_RS21465
uniprot id: A0A0E3SH23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

1434110:MSHOH RS16690
gene id: 1434110:MSHOH_RS16690
uniprot id: A0A0E3SI63
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS02570
gene id: 1434110:MSHOH_RS02570
uniprot id: A0A0E3WV11
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

1434110:MSHOH RS13525
gene id: 1434110:MSHOH_RS13525
uniprot id: A0A0E3SDR8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

1434110:MSHOH RS17465
gene id: 1434110:MSHOH_RS17465
uniprot id: A0A0E3SFB4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS09290
gene id: 1434110:MSHOH_RS09290
uniprot id: A0A0E3S9I2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS20570
gene id: 1434110:MSHOH_RS20570
uniprot id: A0A0E3SGR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434110:MSHOH RS02575
gene id: 1434110:MSHOH_RS02575
uniprot id: A0A0E3S8M1
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS16855
gene id: 1434110:MSHOH_RS16855
uniprot id: A0A0E3SCD8
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

1434110:MSHOH RS03125
gene id: 1434110:MSHOH_RS03125
uniprot id: A0A0E3SCM9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1434110:MSHOH RS17050
gene id: 1434110:MSHOH_RS17050
uniprot id: A0A0E3SGY9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434110:MSHOH RS17725
gene id: 1434110:MSHOH_RS17725
uniprot id: A0A0E3SH87
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS16775
gene id: 1434110:MSHOH_RS16775
uniprot id: A0A0E3SI73
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

1434110:MSHOH RS04390
gene id: 1434110:MSHOH_RS04390
uniprot id: A0A0E3WST7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

1434110:MSHOH RS19465
gene id: 1434110:MSHOH_RS19465
uniprot id: A0A0E3WV81
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

1434110:MSHOH RS03655
gene id: 1434110:MSHOH_RS03655
uniprot id: A0A0E3S756
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434110:MSHOH RS17530
gene id: 1434110:MSHOH_RS17530
uniprot id: A0A0E3SIG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

1434110:MSHOH RS07020
gene id: 1434110:MSHOH_RS07020
uniprot id: A0A0E3S8L2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

1434110:MSHOH RS18715
gene id: 1434110:MSHOH_RS18715
uniprot id: A0A0E3SD77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434110:MSHOH RS19330
gene id: 1434110:MSHOH_RS19330
uniprot id: A0A0E3WV75
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1434110:MSHOH RS00480
gene id: 1434110:MSHOH_RS00480
uniprot id: A0A0E3S7Q0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS03885
gene id: 1434110:MSHOH_RS03885
uniprot id: A0A0E3SCZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex.

1434110:MSHOH RS16545
gene id: 1434110:MSHOH_RS16545
uniprot id: A0A0E3WWH6
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS01115
gene id: 1434110:MSHOH_RS01115
uniprot id: A0A0E3S673
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

1434110:MSHOH RS02035
gene id: 1434110:MSHOH_RS02035
uniprot id: A0A0E3WSX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

1434110:MSHOH RS15205
gene id: 1434110:MSHOH_RS15205
uniprot id: A0A0E3SG77
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS11040
gene id: 1434110:MSHOH_RS11040
uniprot id: A0A0E3SCG9
names: Similarity
messages: Belongs to the UPF0237 family.

1434110:MSHOH RS19060
gene id: 1434110:MSHOH_RS19060
uniprot id: A0A0E3WV67
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1434110:MSHOH RS19630
gene id: 1434110:MSHOH_RS19630
uniprot id: A0A0E3SGA0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS04255
gene id: 1434110:MSHOH_RS04255
uniprot id: A0A0E3S7E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

1434110:MSHOH RS16780
gene id: 1434110:MSHOH_RS16780
uniprot id: A0A0E3SCC6
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

1434110:MSHOH RS17840
gene id: 1434110:MSHOH_RS17840
uniprot id: A0A0E3SFF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1434110:MSHOH RS22025
gene id: 1434110:MSHOH_RS22025
uniprot id: A0A0E3WT40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kinesin light chain family.
messages: cytoskeleton

1434110:MSHOH RS01955
gene id: 1434110:MSHOH_RS01955
uniprot id: A0A0E3WTQ8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

1434110:MSHOH RS19950
gene id: 1434110:MSHOH_RS19950
uniprot id: A0A0E3SDR9
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1434110:MSHOH RS16705
gene id: 1434110:MSHOH_RS16705
uniprot id: A0A0E3SEZ7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS10915
gene id: 1434110:MSHOH_RS10915
uniprot id: A0A0E3SA54
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1434110:MSHOH RS07560
gene id: 1434110:MSHOH_RS07560
uniprot id: A0A0E3SD13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

1434110:MSHOH RS02830
gene id: 1434110:MSHOH_RS02830
uniprot id: A0A0E3SCI5
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

1434110:MSHOH RS14235
gene id: 1434110:MSHOH_RS14235
uniprot id: A0A0E3SBE0
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS12450
gene id: 1434110:MSHOH_RS12450
uniprot id: A0A0E3SDC9
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS02025
gene id: 1434110:MSHOH_RS02025
uniprot id: A0A0E3SC59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1434110:MSHOH RS13150
gene id: 1434110:MSHOH_RS13150
uniprot id: A0A0E3SAY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

1434110:MSHOH RS05855
gene id: 1434110:MSHOH_RS05855
uniprot id: A0A0E3SA11
names: Similarity
messages: Belongs to the peptidase S8 family.

1434110:MSHOH RS17145
gene id: 1434110:MSHOH_RS17145
uniprot id: A0A0E3SIC6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1434110:MSHOH RS12265
gene id: 1434110:MSHOH_RS12265
uniprot id: A0A0E3SD11
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

1434110:MSHOH RS12030
gene id: 1434110:MSHOH_RS12030
uniprot id: A0A0E3SAK0
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1434110:MSHOH RS18150
gene id: 1434110:MSHOH_RS18150
uniprot id: A0A0E3SFJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1434110:MSHOH RS20600
gene id: 1434110:MSHOH_RS20600
uniprot id: A0A0E3SGS2
names: Subunit
messages: Homotetramer.

1434110:MSHOH RS03895
gene id: 1434110:MSHOH_RS03895
uniprot id: A0A0E3WT49
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

1434110:MSHOH RS00390
gene id: 1434110:MSHOH_RS00390
uniprot id: A0A0E3SA74
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS20510
gene id: 1434110:MSHOH_RS20510
uniprot id: A0A0E3SDZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS18980
gene id: 1434110:MSHOH_RS18980
uniprot id: A0A0E3WVM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1434110:MSHOH RS03750
gene id: 1434110:MSHOH_RS03750
uniprot id: A0A0E3S773
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

1434110:MSHOH RS01090
gene id: 1434110:MSHOH_RS01090
uniprot id: A0A0E3WTR2
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1434110:MSHOH RS02260
gene id: 1434110:MSHOH_RS02260
uniprot id: A0A0E3S6N9
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS15475
gene id: 1434110:MSHOH_RS15475
uniprot id: A0A0E3SHQ6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1434110:MSHOH RS14935
gene id: 1434110:MSHOH_RS14935
uniprot id: A0A0E3SG55
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS06140
gene id: 1434110:MSHOH_RS06140
uniprot id: A0A0E3S862
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1434110:MSHOH RS08175
gene id: 1434110:MSHOH_RS08175
uniprot id: A0A0E3WTK6
names: Similarity
messages: Belongs to the UPF0282 family.

1434110:MSHOH RS03420
gene id: 1434110:MSHOH_RS03420
uniprot id: A0A0E3WTU1
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

1434110:MSHOH RS09730
gene id: 1434110:MSHOH_RS09730
uniprot id: A0A0E3SBS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1434110:MSHOH RS02105
gene id: 1434110:MSHOH_RS02105
uniprot id: A0A0E3SC75
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1434110:MSHOH RS21395
gene id: 1434110:MSHOH_RS21395
uniprot id: A0A0E3SH17
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

1434110:MSHOH RS18575
gene id: 1434110:MSHOH_RS18575
uniprot id: A0A0E3SIS6
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

1434110:MSHOH RS09295
gene id: 1434110:MSHOH_RS09295
uniprot id: A0A0E3WU49
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS13535
gene id: 1434110:MSHOH_RS13535
uniprot id: A0A0E3SH44
names: Subcellular Location Annotation
messages: Cytoplasm

1434110:MSHOH RS19475
gene id: 1434110:MSHOH_RS19475
uniprot id: A0A0E3SI20
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1434110:MSHOH RS07330
gene id: 1434110:MSHOH_RS07330
uniprot id: A0A0E3SCY6
names: Similarity
messages: Belongs to the GARS family.

1434110:MSHOH RS17470
gene id: 1434110:MSHOH_RS17470
uniprot id: A0A0E3SH45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

1434110:MSHOH RS10500
gene id: 1434110:MSHOH_RS10500
uniprot id: A0A0E3WTD5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1434110:MSHOH RS18710
gene id: 1434110:MSHOH_RS18710
uniprot id: A0A0E3SIT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

1434110:MSHOH RS20860
gene id: 1434110:MSHOH_RS20860
uniprot id: A0A0E3SE41
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS04360
gene id: 1434110:MSHOH_RS04360
uniprot id: A0A0E3WTV1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

1434110:MSHOH RS06260
gene id: 1434110:MSHOH_RS06260
uniprot id: A0A0E3SCK0
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

1434110:MSHOH RS16675
gene id: 1434110:MSHOH_RS16675
uniprot id: A0A0E3WWH9
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS02045
gene id: 1434110:MSHOH_RS02045
uniprot id: A0A0E3SAW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

1434110:MSHOH RS20515
gene id: 1434110:MSHOH_RS20515
uniprot id: A0A0E3WVB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434110:MSHOH RS12965
gene id: 1434110:MSHOH_RS12965
uniprot id: A0A0E3SDK6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS04195
gene id: 1434110:MSHOH_RS04195
uniprot id: A0A0E3SD30
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

1434110:MSHOH RS12860
gene id: 1434110:MSHOH_RS12860
uniprot id: A0A0E3SDJ5
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS03710
gene id: 1434110:MSHOH_RS03710
uniprot id: A0A0E3S974
names: Similarity
messages: Belongs to the P(II) protein family.

1434110:MSHOH RS19390
gene id: 1434110:MSHOH_RS19390
uniprot id: A0A0E3SG37
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

1434110:MSHOH RS18170
gene id: 1434110:MSHOH_RS18170
uniprot id: A0A0E3WUA2
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS16820
gene id: 1434110:MSHOH_RS16820
uniprot id: A0A0E3SGU5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

1434110:MSHOH RS06350
gene id: 1434110:MSHOH_RS06350
uniprot id: A0A0E3WUB5
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

1434110:MSHOH RS13905
gene id: 1434110:MSHOH_RS13905
uniprot id: A0A0E3SFQ1
names: Similarity
messages: Belongs to the UPF0280 family.

1434110:MSHOH RS01915
gene id: 1434110:MSHOH_RS01915
uniprot id: A0A0E3SC39
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS20525
gene id: 1434110:MSHOH_RS20525
uniprot id: A0A0E3SIH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1434110:MSHOH RS20520
gene id: 1434110:MSHOH_RS20520
uniprot id: A0A0E3SGQ9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

1434110:MSHOH RS05420
gene id: 1434110:MSHOH_RS05420
uniprot id: A0A0E3S7X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434110:MSHOH RS21435
gene id: 1434110:MSHOH_RS21435
uniprot id: A0A0E3SIY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1434110:MSHOH RS09845
gene id: 1434110:MSHOH_RS09845
uniprot id: A0A0E3WTB7
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS17245
gene id: 1434110:MSHOH_RS17245
uniprot id: A0A0E3SID8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1434110:MSHOH RS03240
gene id: 1434110:MSHOH_RS03240
uniprot id: A0A0E3SBE1
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

1434110:MSHOH RS15085
gene id: 1434110:MSHOH_RS15085
uniprot id: A0A0E3SHL4
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

1434110:MSHOH RS03425
gene id: 1434110:MSHOH_RS03425
uniprot id: A0A0E3S8Z0
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1434110:MSHOH RS21485
gene id: 1434110:MSHOH_RS21485
uniprot id: A0A0E3WVR9
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1434110:MSHOH RS15465
gene id: 1434110:MSHOH_RS15465
uniprot id: A0A0E3SGA7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

1434110:MSHOH RS03905
gene id: 1434110:MSHOH_RS03905
uniprot id: A0A0E3SBN4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

1434110:MSHOH RS03965
gene id: 1434110:MSHOH_RS03965
uniprot id: A0A0E3SD03
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1434110:MSHOH RS14895
gene id: 1434110:MSHOH_RS14895
uniprot id: A0A0E3SBN5
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

1434110:MSHOH RS15580
gene id: 1434110:MSHOH_RS15580
uniprot id: A0A0E3SBX0
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS05415
gene id: 1434110:MSHOH_RS05415
uniprot id: A0A0E3SDH8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1434110:MSHOH RS17605
gene id: 1434110:MSHOH_RS17605
uniprot id: A0A0E3SH66
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS19040
gene id: 1434110:MSHOH_RS19040
uniprot id: A0A0E3SFX8
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

1434110:MSHOH RS04180
gene id: 1434110:MSHOH_RS04180
uniprot id: A0A0E3S9C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

1434110:MSHOH RS09150
gene id: 1434110:MSHOH_RS09150
uniprot id: A0A0E3WU45
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1434110:MSHOH RS07130
gene id: 1434110:MSHOH_RS07130
uniprot id: A0A0E3SCU8
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434110:MSHOH RS21185
gene id: 1434110:MSHOH_RS21185
uniprot id: A0A0E3SJL3
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS20790
gene id: 1434110:MSHOH_RS20790
uniprot id: A0A0E3SIK4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity.

1434110:MSHOH RS11425
gene id: 1434110:MSHOH_RS11425
uniprot id: A0A0E3SAB3
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

1434110:MSHOH RS03555
gene id: 1434110:MSHOH_RS03555
uniprot id: A0A0E3S934
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

1434110:MSHOH RS15220
gene id: 1434110:MSHOH_RS15220
uniprot id: A0A0E3WV89
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS06540
gene id: 1434110:MSHOH_RS06540
uniprot id: A0A0E3SE29
names: Function
messages: Part of a potassium transport system.

1434110:MSHOH RS16205
gene id: 1434110:MSHOH_RS16205
uniprot id: A0A0E3SC45
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS02485
gene id: 1434110:MSHOH_RS02485
uniprot id: A0A0E3SCD7
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

1434110:MSHOH RS09735
gene id: 1434110:MSHOH_RS09735
uniprot id: A0A0E3SDV6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS01360
gene id: 1434110:MSHOH_RS01360
uniprot id: A0A0E3SAP6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1434110:MSHOH RS20835
gene id: 1434110:MSHOH_RS20835
uniprot id: A0A0E3SE37
names: Similarity
messages: Belongs to the peptidase M24B family.

1434110:MSHOH RS04985
gene id: 1434110:MSHOH_RS04985
uniprot id: A0A0E3S9N0
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

1434110:MSHOH RS10580
gene id: 1434110:MSHOH_RS10580
uniprot id: A0A0E3WVU0
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS03220
gene id: 1434110:MSHOH_RS03220
uniprot id: A0A0E3SCP2
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1434110:MSHOH RS11710
gene id: 1434110:MSHOH_RS11710
uniprot id: A0A0E3SES0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434110:MSHOH RS10555
gene id: 1434110:MSHOH_RS10555
uniprot id: A0A0E3WTU0
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS11325
gene id: 1434110:MSHOH_RS11325
uniprot id: A0A0E3SAA2
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS09555
gene id: 1434110:MSHOH_RS09555
uniprot id: A0A0E3WU58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

1434110:MSHOH RS18090
gene id: 1434110:MSHOH_RS18090
uniprot id: A0A0E3WUU6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

1434110:MSHOH RS10420
gene id: 1434110:MSHOH_RS10420
uniprot id: A0A0E3SC70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1434110:MSHOH RS11180
gene id: 1434110:MSHOH_RS11180
uniprot id: A0A0E3SA84
names: Similarity
messages: Belongs to the CutA family.

1434110:MSHOH RS06270
gene id: 1434110:MSHOH_RS06270
uniprot id: A0A0E3S8A4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

1434110:MSHOH RS14580
gene id: 1434110:MSHOH_RS14580
uniprot id: A0A0E3SFZ9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

1434110:MSHOH RS01175
gene id: 1434110:MSHOH_RS01175
uniprot id: A0A0E3S814
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1434110:MSHOH RS04170
gene id: 1434110:MSHOH_RS04170
uniprot id: A0A0E3S7C9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

1434110:MSHOH RS20930
gene id: 1434110:MSHOH_RS20930
uniprot id: A0A0E3SIL9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1434110:MSHOH RS21490
gene id: 1434110:MSHOH_RS21490
uniprot id: A0A0E3SH27
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1434110:MSHOH RS18530
gene id: 1434110:MSHOH_RS18530
uniprot id: A0A0E3SFQ5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

1434110:MSHOH RS03745
gene id: 1434110:MSHOH_RS03745
uniprot id: A0A0E3SCX1
names: Similarity
messages: Belongs to the pyruvate kinase family.

1434110:MSHOH RS03215
gene id: 1434110:MSHOH_RS03215
uniprot id: A0A0E3SBD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

1434110:MSHOH RS14665
gene id: 1434110:MSHOH_RS14665
uniprot id: A0A0E3SG12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

1434110:MSHOH RS03105
gene id: 1434110:MSHOH_RS03105
uniprot id: A0A0E3SCM6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

1434110:MSHOH RS00270
gene id: 1434110:MSHOH_RS00270
uniprot id: A0A0E3WTG5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS16250
gene id: 1434110:MSHOH_RS16250
uniprot id: A0A0E3SHZ4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

1434110:MSHOH RS20945
gene id: 1434110:MSHOH_RS20945
uniprot id: A0A0E3WUI6
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS15485
gene id: 1434110:MSHOH_RS15485
uniprot id: A0A0E3WV96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1434110:MSHOH RS16420
gene id: 1434110:MSHOH_RS16420
uniprot id: A0A0E3SGP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1434110:MSHOH RS19560
gene id: 1434110:MSHOH_RS19560
uniprot id: A0A0E3SI37
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS12815
gene id: 1434110:MSHOH_RS12815
uniprot id: A0A0E3SF53
names: Similarity
messages: Belongs to the class-I fumarase family.

1434110:MSHOH RS17105
gene id: 1434110:MSHOH_RS17105
uniprot id: A0A0E3WUZ8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1434110:MSHOH RS16300
gene id: 1434110:MSHOH_RS16300
uniprot id: A0A0E3SI02
names: Similarity
messages: Belongs to the UPF0047 family.

1434110:MSHOH RS21410
gene id: 1434110:MSHOH_RS21410
uniprot id: A0A0E3SEB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

1434110:MSHOH RS18745
gene id: 1434110:MSHOH_RS18745
uniprot id: A0A0E3WUW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

1434110:MSHOH RS10735
gene id: 1434110:MSHOH_RS10735
uniprot id: A0A0E3SA29
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS09955
gene id: 1434110:MSHOH_RS09955
uniprot id: A0A0E3SDY3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

1434110:MSHOH RS14600
gene id: 1434110:MSHOH_RS14600
uniprot id: A0A0E3SE82
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS15705
gene id: 1434110:MSHOH_RS15705
uniprot id: A0A0E3SEM3
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS09630
gene id: 1434110:MSHOH_RS09630
uniprot id: A0A0E3S9N1
names: Similarity
messages: Belongs to the AOR/FOR family.

1434110:MSHOH RS14425
gene id: 1434110:MSHOH_RS14425
uniprot id: A0A0E3SFY1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1434110:MSHOH RS05410
gene id: 1434110:MSHOH_RS05410
uniprot id: A0A0E3SC71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

1434110:MSHOH RS17990
gene id: 1434110:MSHOH_RS17990
uniprot id: A0A0E3SFH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

1434110:MSHOH RS19410
gene id: 1434110:MSHOH_RS19410
uniprot id: A0A0E3SDG5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1434110:MSHOH RS21010
gene id: 1434110:MSHOH_RS21010
uniprot id: A0A0E3SE59
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1434110:MSHOH RS09190
gene id: 1434110:MSHOH_RS09190
uniprot id: A0A0E3SDM6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1434110:MSHOH RS20585
gene id: 1434110:MSHOH_RS20585
uniprot id: A0A0E3SE04
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

1434110:MSHOH RS05085
gene id: 1434110:MSHOH_RS05085
uniprot id: A0A0E3S9P4
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1434110:MSHOH RS13835
gene id: 1434110:MSHOH_RS13835
uniprot id: A0A0E3SH89
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1434110:MSHOH RS21530
gene id: 1434110:MSHOH_RS21530
uniprot id: A0A0E3SJP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

1434110:MSHOH RS15335
gene id: 1434110:MSHOH_RS15335
uniprot id: A0A0E3SHP3
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS17115
gene id: 1434110:MSHOH_RS17115
uniprot id: A0A0E3SGZ5
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS21590
gene id: 1434110:MSHOH_RS21590
uniprot id: A0A0E3WUK8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS15170
gene id: 1434110:MSHOH_RS15170
uniprot id: A0A0E3WUT0
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

1434110:MSHOH RS02765
gene id: 1434110:MSHOH_RS02765
uniprot id: A0A0E3S8Q0
names: Similarity
messages: Belongs to the peptidase S49 family.

1434110:MSHOH RS10960
gene id: 1434110:MSHOH_RS10960
uniprot id: A0A0E3SEE0
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

1434110:MSHOH RS00170
gene id: 1434110:MSHOH_RS00170
uniprot id: A0A0E3WTM7
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1434110:MSHOH RS13310
gene id: 1434110:MSHOH_RS13310
uniprot id: A0A0E3SH21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1434110:MSHOH RS20325
gene id: 1434110:MSHOH_RS20325
uniprot id: A0A0E3WV27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS18985
gene id: 1434110:MSHOH_RS18985
uniprot id: A0A0E3SFX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1434110:MSHOH RS12170
gene id: 1434110:MSHOH_RS12170
uniprot id: A0A0E3SEX0
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS17165
gene id: 1434110:MSHOH_RS17165
uniprot id: A0A0E3SH04
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

1434110:MSHOH RS19615
gene id: 1434110:MSHOH_RS19615
uniprot id: A0A0E3SJ21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.
messages: Monomer and homodimer.

1434110:MSHOH RS07960
gene id: 1434110:MSHOH_RS07960
uniprot id: A0A0E3SEN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1434110:MSHOH RS02410
gene id: 1434110:MSHOH_RS02410
uniprot id: A0A0E3SCC5
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS01855
gene id: 1434110:MSHOH_RS01855
uniprot id: A0A0E3SAU9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434110:MSHOH RS07345
gene id: 1434110:MSHOH_RS07345
uniprot id: A0A0E3WUE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

1434110:MSHOH RS15445
gene id: 1434110:MSHOH_RS15445
uniprot id: A0A0E3SHQ5
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1434110:MSHOH RS21250
gene id: 1434110:MSHOH_RS21250
uniprot id: A0A0E3SH00
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

1434110:MSHOH RS19440
gene id: 1434110:MSHOH_RS19440
uniprot id: A0A0E3WWR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

1434110:MSHOH RS17545
gene id: 1434110:MSHOH_RS17545
uniprot id: A0A0E3SFC3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

1434110:MSHOH RS19660
gene id: 1434110:MSHOH_RS19660
uniprot id: A0A0E3SGC4
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434110:MSHOH RS06090
gene id: 1434110:MSHOH_RS06090
uniprot id: A0A0E3WUA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

1434110:MSHOH RS01590
gene id: 1434110:MSHOH_RS01590
uniprot id: A0A0E3WSI0
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS00015
gene id: 1434110:MSHOH_RS00015
uniprot id: A0A0E3S7I2
names: Similarity
messages: Belongs to the UPF0201 family.

1434110:MSHOH RS03540
gene id: 1434110:MSHOH_RS03540
uniprot id: A0A0E3SCT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

1434110:MSHOH RS12335
gene id: 1434110:MSHOH_RS12335
uniprot id: A0A0E3WU56
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

1434110:MSHOH RS15855
gene id: 1434110:MSHOH_RS15855
uniprot id: A0A0E3SGF7
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

1434110:MSHOH RS09345
gene id: 1434110:MSHOH_RS09345
uniprot id: A0A0E3SDQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

1434110:MSHOH RS17835
gene id: 1434110:MSHOH_RS17835
uniprot id: A0A0E3WUT8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS19830
gene id: 1434110:MSHOH_RS19830
uniprot id: A0A0E3SJ59
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

1434110:MSHOH RS20330
gene id: 1434110:MSHOH_RS20330
uniprot id: A0A0E3SGN2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS03575
gene id: 1434110:MSHOH_RS03575
uniprot id: A0A0E3S738
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0060 family.
messages: Cell membrane

1434110:MSHOH RS03695
gene id: 1434110:MSHOH_RS03695
uniprot id: A0A0E3SCW4
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

1434110:MSHOH RS03060
gene id: 1434110:MSHOH_RS03060
uniprot id: A0A0E3WU07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1434110:MSHOH RS19400
gene id: 1434110:MSHOH_RS19400
uniprot id: A0A0E3SI09
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

1434110:MSHOH RS03900
gene id: 1434110:MSHOH_RS03900
uniprot id: A0A0E3S997
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

1434110:MSHOH RS02330
gene id: 1434110:MSHOH_RS02330
uniprot id: A0A0E3SCB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS13750
gene id: 1434110:MSHOH_RS13750
uniprot id: A0A0E3SB80
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

1434110:MSHOH RS02835
gene id: 1434110:MSHOH_RS02835
uniprot id: A0A0E3S6X3
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1434110:MSHOH RS15090
gene id: 1434110:MSHOH_RS15090
uniprot id: A0A0E3SBQ9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1434110:MSHOH RS16835
gene id: 1434110:MSHOH_RS16835
uniprot id: A0A0E3WUY9
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

1434110:MSHOH RS00750
gene id: 1434110:MSHOH_RS00750
uniprot id: A0A0E3WUS1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1434110:MSHOH RS09485
gene id: 1434110:MSHOH_RS09485
uniprot id: A0A0E3WUK7
names: Similarity
messages: Belongs to the UPF0111 family.

1434110:MSHOH RS15725
gene id: 1434110:MSHOH_RS15725
uniprot id: A0A0E3WU15
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS05820
gene id: 1434110:MSHOH_RS05820
uniprot id: A0A0E3SCC7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1434110:MSHOH RS17870
gene id: 1434110:MSHOH_RS17870
uniprot id: A0A0E3SHA3
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

1434110:MSHOH RS16305
gene id: 1434110:MSHOH_RS16305
uniprot id: A0A0E3SC61
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1434110:MSHOH RS20550
gene id: 1434110:MSHOH_RS20550
uniprot id: A0A0E3SIH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434110:MSHOH RS13250
gene id: 1434110:MSHOH_RS13250
uniprot id: A0A0E3SDN6
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS13660
gene id: 1434110:MSHOH_RS13660
uniprot id: A0A0E3SDT4
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1434110:MSHOH RS09520
gene id: 1434110:MSHOH_RS09520
uniprot id: A0A0E3SDS7
names: Subcellular Location Annotation
messages: Cell membrane

1434110:MSHOH RS06840
gene id: 1434110:MSHOH_RS06840
uniprot id: A0A0E3SCS2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS00220
gene id: 1434110:MSHOH_RS00220
uniprot id: A0A0E3WSI2
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

1434110:MSHOH RS02930
gene id: 1434110:MSHOH_RS02930
uniprot id: A0A0E3WU04
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1434110:MSHOH RS17220
gene id: 1434110:MSHOH_RS17220
uniprot id: A0A0E3SID5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

1434110:MSHOH RS18680
gene id: 1434110:MSHOH_RS18680
uniprot id: A0A0E3SHK7
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

1434110:MSHOH RS10485
gene id: 1434110:MSHOH_RS10485
uniprot id: A0A0E3SE60
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

1434110:MSHOH RS06705
gene id: 1434110:MSHOH_RS06705
uniprot id: A0A0E3SE51
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1434110:MSHOH RS07010
gene id: 1434110:MSHOH_RS07010
uniprot id: A0A0E3SE93
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.

1434110:MSHOH RS08195
gene id: 1434110:MSHOH_RS08195
uniprot id: A0A0E3S924
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434110:MSHOH RS04155
gene id: 1434110:MSHOH_RS04155
uniprot id: A0A0E3SBR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1434110:MSHOH RS18480
gene id: 1434110:MSHOH_RS18480
uniprot id: A0A0E3SFP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

1434110:MSHOH RS20205
gene id: 1434110:MSHOH_RS20205
uniprot id: A0A0E3SGL2
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1434110:MSHOH RS04045
gene id: 1434110:MSHOH_RS04045
uniprot id: A0A0E3S9B0
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

1434110:MSHOH RS07300
gene id: 1434110:MSHOH_RS07300
uniprot id: A0A0E3SED2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kinesin light chain family.
messages: cytoskeleton

1434110:MSHOH RS17495
gene id: 1434110:MSHOH_RS17495
uniprot id: A0A0E3SH50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1434110:MSHOH RS06095
gene id: 1434110:MSHOH_RS06095
uniprot id: A0A0E3SA45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

1434110:MSHOH RS13730
gene id: 1434110:MSHOH_RS13730
uniprot id: A0A0E3WUA8
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1434110:MSHOH RS17905
gene id: 1434110:MSHOH_RS17905
uniprot id: A0A0E3SCW1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434110:MSHOH RS20050
gene id: 1434110:MSHOH_RS20050
uniprot id: A0A0E3SIB9
names: Function
names: Similarity
messages: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

1434110:MSHOH RS21235
gene id: 1434110:MSHOH_RS21235
uniprot id: A0A0E3SJM0
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

1434110:MSHOH RS20900
gene id: 1434110:MSHOH_RS20900
uniprot id: A0A0E3SGW1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS09825
gene id: 1434110:MSHOH_RS09825
uniprot id: A0A0E3SBU4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1434110:MSHOH RS02625
gene id: 1434110:MSHOH_RS02625
uniprot id: A0A0E3S8M9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1434110:MSHOH RS05070
gene id: 1434110:MSHOH_RS05070
uniprot id: A0A0E3S7R5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1434110:MSHOH RS18730
gene id: 1434110:MSHOH_RS18730
uniprot id: A0A0E3SHL6
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

1434110:MSHOH RS16290
gene id: 1434110:MSHOH_RS16290
uniprot id: A0A0E3SEU5
names: Similarity
messages: Belongs to the UPF0173 family.

1434110:MSHOH RS04375
gene id: 1434110:MSHOH_RS04375
uniprot id: A0A0E3SBU2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

1434110:MSHOH RS11045
gene id: 1434110:MSHOH_RS11045
uniprot id: A0A0E3SEF4
names: Similarity
messages: Belongs to the TrpF family.

1434110:MSHOH RS06455
gene id: 1434110:MSHOH_RS06455
uniprot id: A0A0E3SAB9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS17825
gene id: 1434110:MSHOH_RS17825
uniprot id: A0A0E3SIJ2
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1434110:MSHOH RS13375
gene id: 1434110:MSHOH_RS13375
uniprot id: A0A0E3SB22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Homodimer.

1434110:MSHOH RS02145
gene id: 1434110:MSHOH_RS02145
uniprot id: A0A0E3S8F1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1434110:MSHOH RS21170
gene id: 1434110:MSHOH_RS21170
uniprot id: A0A0E3SGZ1
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434110:MSHOH RS17670
gene id: 1434110:MSHOH_RS17670
uniprot id: A0A0E3SFD6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1434110:MSHOH RS21540
gene id: 1434110:MSHOH_RS21540
uniprot id: A0A0E3WWX9
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

1434110:MSHOH RS17175
gene id: 1434110:MSHOH_RS17175
uniprot id: A0A0E3SCJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1434110:MSHOH RS07990
gene id: 1434110:MSHOH_RS07990
uniprot id: A0A0E3S901
names: Similarity
messages: Belongs to the heat shock protein 90 family.

1434110:MSHOH RS18975
gene id: 1434110:MSHOH_RS18975
uniprot id: A0A0E3SDB0
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS09315
gene id: 1434110:MSHOH_RS09315
uniprot id: A0A0E3SBK5
names: Subcellular Location Annotation
messages: Cell membrane

1434110:MSHOH RS11705
gene id: 1434110:MSHOH_RS11705
uniprot id: A0A0E3SCS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434110:MSHOH RS19905
gene id: 1434110:MSHOH_RS19905
uniprot id: A0A0E3SJ69
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1434110:MSHOH RS02650
gene id: 1434110:MSHOH_RS02650
uniprot id: A0A0E3S8N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434110:MSHOH RS07205
gene id: 1434110:MSHOH_RS07205
uniprot id: A0A0E3SCV0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1434110:MSHOH RS09830
gene id: 1434110:MSHOH_RS09830
uniprot id: A0A0E3SDW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS04355
gene id: 1434110:MSHOH_RS04355
uniprot id: A0A0E3S7F7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

1434110:MSHOH RS16415
gene id: 1434110:MSHOH_RS16415
uniprot id: A0A0E3SEW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

1434110:MSHOH RS08290
gene id: 1434110:MSHOH_RS08290
uniprot id: A0A0E3SF10
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS09740
gene id: 1434110:MSHOH_RS09740
uniprot id: A0A0E3SFM8
names: Similarity
messages: Belongs to the TrpF family.

1434110:MSHOH RS17980
gene id: 1434110:MSHOH_RS17980
uniprot id: A0A0E3SCX0
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434110:MSHOH RS16985
gene id: 1434110:MSHOH_RS16985
uniprot id: A0A0E3SCG0
names: Subcellular Location Annotation
messages: Cell membrane

1434110:MSHOH RS22270
gene id: 1434110:MSHOH_RS22270
uniprot id: A0A0E3SBL7
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS20740
gene id: 1434110:MSHOH_RS20740
uniprot id: A0A0E3SJF6
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS19120
gene id: 1434110:MSHOH_RS19120
uniprot id: A0A0E3SHT8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS16185
gene id: 1434110:MSHOH_RS16185
uniprot id: A0A0E3WUW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS00090
gene id: 1434110:MSHOH_RS00090
uniprot id: A0A0E3S7J4
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

1434110:MSHOH RS18810
gene id: 1434110:MSHOH_RS18810
uniprot id: A0A0E3SHN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434110:MSHOH RS02300
gene id: 1434110:MSHOH_RS02300
uniprot id: A0A0E3SB02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

1434110:MSHOH RS13850
gene id: 1434110:MSHOH_RS13850
uniprot id: A0A0E3SDW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1434110:MSHOH RS19780
gene id: 1434110:MSHOH_RS19780
uniprot id: A0A0E3SGF0
names: Similarity
messages: Belongs to the HsdR family.

1434110:MSHOH RS21145
gene id: 1434110:MSHOH_RS21145
uniprot id: A0A0E3SIP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1434110:MSHOH RS12810
gene id: 1434110:MSHOH_RS12810
uniprot id: A0A0E3SDJ1
names: Similarity
messages: Belongs to the class-I fumarase family.

1434110:MSHOH RS15880
gene id: 1434110:MSHOH_RS15880
uniprot id: A0A0E3SGG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

1434110:MSHOH RS17200
gene id: 1434110:MSHOH_RS17200
uniprot id: A0A0E3SCJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

1434110:MSHOH RS00765
gene id: 1434110:MSHOH_RS00765
uniprot id: A0A0E3SBH2
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1434110:MSHOH RS12555
gene id: 1434110:MSHOH_RS12555
uniprot id: A0A0E3SDE7
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1434110:MSHOH RS05160
gene id: 1434110:MSHOH_RS05160
uniprot id: A0A0E3S7S9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

1434110:MSHOH RS10285
gene id: 1434110:MSHOH_RS10285
uniprot id: A0A0E3WTT0
names: Similarity
messages: Belongs to the group II decarboxylase family.

1434110:MSHOH RS15945
gene id: 1434110:MSHOH_RS15945
uniprot id: A0A0E3WUV9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434110:MSHOH RS21955
gene id: 1434110:MSHOH_RS21955
uniprot id: A0A0E3S9N7
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS01935
gene id: 1434110:MSHOH_RS01935
uniprot id: A0A0E3S8B6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS15780
gene id: 1434110:MSHOH_RS15780
uniprot id: A0A0E3SEN4
names: Caution
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transcriptional regulator.

1434110:MSHOH RS16510
gene id: 1434110:MSHOH_RS16510
uniprot id: A0A0E3SI32
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

1434110:MSHOH RS02365
gene id: 1434110:MSHOH_RS02365
uniprot id: A0A0E3WSM0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS03620
gene id: 1434110:MSHOH_RS03620
uniprot id: A0A0E3SCV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS03715
gene id: 1434110:MSHOH_RS03715
uniprot id: A0A0E3SBK9
names: Similarity
messages: Belongs to the P(II) protein family.

1434110:MSHOH RS19315
gene id: 1434110:MSHOH_RS19315
uniprot id: A0A0E3SHZ6
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

1434110:MSHOH RS06535
gene id: 1434110:MSHOH_RS06535
uniprot id: A0A0E3SCP3
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

1434110:MSHOH RS20545
gene id: 1434110:MSHOH_RS20545
uniprot id: A0A0E3SGR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434110:MSHOH RS18220
gene id: 1434110:MSHOH_RS18220
uniprot id: A0A0E3WUV0
names: Similarity
messages: Belongs to the catalase family.

1434110:MSHOH RS04775
gene id: 1434110:MSHOH_RS04775
uniprot id: A0A0E3WTV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homodimer.

1434110:MSHOH RS03430
gene id: 1434110:MSHOH_RS03430
uniprot id: A0A0E3SBF9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS17155
gene id: 1434110:MSHOH_RS17155
uniprot id: A0A0E3WVF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1434110:MSHOH RS08125
gene id: 1434110:MSHOH_RS08125
uniprot id: A0A0E3WT64
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

1434110:MSHOH RS10745
gene id: 1434110:MSHOH_RS10745
uniprot id: A0A0E3SCC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1434110:MSHOH RS08740
gene id: 1434110:MSHOH_RS08740
uniprot id: A0A0E3SBA3
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS07340
gene id: 1434110:MSHOH_RS07340
uniprot id: A0A0E3S8P9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS16890
gene id: 1434110:MSHOH_RS16890
uniprot id: A0A0E3SF23
names: Similarity
messages: Belongs to the HypD family.

1434110:MSHOH RS15185
gene id: 1434110:MSHOH_RS15185
uniprot id: A0A0E3SHM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: FPO is composed of at least 12 different subunits. Subunits FpoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: FPO shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to quinones in the F(420)H(2):heterodisulfide oxidoreduction chain. The immediate electron acceptor for the enzyme in this species is believed to be methanophenazine. Couples the redox reaction to proton translocation (for every two electrons transferred, 0.9 hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
messages: Membrane

1434110:MSHOH RS01750
gene id: 1434110:MSHOH_RS01750
uniprot id: A0A0E3S6H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS02425
gene id: 1434110:MSHOH_RS02425
uniprot id: A0A0E3S8J6
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

1434110:MSHOH RS16320
gene id: 1434110:MSHOH_RS16320
uniprot id: A0A0E3SI06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1434110:MSHOH RS16225
gene id: 1434110:MSHOH_RS16225
uniprot id: A0A0E3SHZ1
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

1434110:MSHOH RS12640
gene id: 1434110:MSHOH_RS12640
uniprot id: A0A0E3WU65
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

1434110:MSHOH RS14885
gene id: 1434110:MSHOH_RS14885
uniprot id: A0A0E3SG49
names: Similarity
messages: Belongs to the Nudix hydrolase family. NudC subfamily.

1434110:MSHOH RS00275
gene id: 1434110:MSHOH_RS00275
uniprot id: A0A0E3S7M1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS20800
gene id: 1434110:MSHOH_RS20800
uniprot id: A0A0E3SE34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1434110:MSHOH RS03015
gene id: 1434110:MSHOH_RS03015
uniprot id: A0A0E3SBB2
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

1434110:MSHOH RS15295
gene id: 1434110:MSHOH_RS15295
uniprot id: A0A0E3SBT3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

1434110:MSHOH RS08610
gene id: 1434110:MSHOH_RS08610
uniprot id: A0A0E3SDC3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS18495
gene id: 1434110:MSHOH_RS18495
uniprot id: A0A0E3SD38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

1434110:MSHOH RS13530
gene id: 1434110:MSHOH_RS13530
uniprot id: A0A0E3SFJ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1434110:MSHOH RS18895
gene id: 1434110:MSHOH_RS18895
uniprot id: A0A0E3SDA2
names: Similarity
messages: Belongs to the MCM family.

1434110:MSHOH RS01045
gene id: 1434110:MSHOH_RS01045
uniprot id: A0A0E3WTK1
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS06445
gene id: 1434110:MSHOH_RS06445
uniprot id: A0A0E3S8D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS00295
gene id: 1434110:MSHOH_RS00295
uniprot id: A0A0E3WS97
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1434110:MSHOH RS18945
gene id: 1434110:MSHOH_RS18945
uniprot id: A0A0E3SIV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

1434110:MSHOH RS06450
gene id: 1434110:MSHOH_RS06450
uniprot id: A0A0E3WT14
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS10925
gene id: 1434110:MSHOH_RS10925
uniprot id: A0A0E3SCF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

1434110:MSHOH RS02195
gene id: 1434110:MSHOH_RS02195
uniprot id: A0A0E3S8F9
names: Similarity
messages: Belongs to the HdrC family.

1434110:MSHOH RS05615
gene id: 1434110:MSHOH_RS05615
uniprot id: A0A0E3WVB1
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

1434110:MSHOH RS03440
gene id: 1434110:MSHOH_RS03440
uniprot id: A0A0E3S724
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

1434110:MSHOH RS07355
gene id: 1434110:MSHOH_RS07355
uniprot id: A0A0E3SCZ1
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

1434110:MSHOH RS10470
gene id: 1434110:MSHOH_RS10470
uniprot id: A0A0E3S9Z3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1434110:MSHOH RS00240
gene id: 1434110:MSHOH_RS00240
uniprot id: A0A0E3S5S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434110:MSHOH RS18995
gene id: 1434110:MSHOH_RS18995
uniprot id: A0A0E3SIW1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

1434110:MSHOH RS15270
gene id: 1434110:MSHOH_RS15270
uniprot id: A0A0E3SBS9
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS02030
gene id: 1434110:MSHOH_RS02030
uniprot id: A0A0E3S6L5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1434110:MSHOH RS15585
gene id: 1434110:MSHOH_RS15585
uniprot id: A0A0E3WU14
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434110:MSHOH RS16825
gene id: 1434110:MSHOH_RS16825
uniprot id: A0A0E3SI80
names: Similarity
messages: Belongs to the FBPase class 2 family.

1434110:MSHOH RS12010
gene id: 1434110:MSHOH_RS12010
uniprot id: A0A0E3SCW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1434110:MSHOH RS03040
gene id: 1434110:MSHOH_RS03040
uniprot id: A0A0E3SBB6
names: Similarity
messages: Belongs to the UPF0292 family.

1434110:MSHOH RS19235
gene id: 1434110:MSHOH_RS19235
uniprot id: A0A0E3SDE8
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS08570
gene id: 1434110:MSHOH_RS08570
uniprot id: A0A0E3S965
names: Similarity
messages: Belongs to the UPF0228 family.

1434110:MSHOH RS00370
gene id: 1434110:MSHOH_RS00370
uniprot id: A0A0E3SBB0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS19110
gene id: 1434110:MSHOH_RS19110
uniprot id: A0A0E3WVM5
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1434110:MSHOH RS10795
gene id: 1434110:MSHOH_RS10795
uniprot id: A0A0E3SCD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

1434110:MSHOH RS17185
gene id: 1434110:MSHOH_RS17185
uniprot id: A0A0E3SF81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1434110:MSHOH RS00245
gene id: 1434110:MSHOH_RS00245
uniprot id: A0A0E3WUQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434110:MSHOH RS05810
gene id: 1434110:MSHOH_RS05810
uniprot id: A0A0E3WU94
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1434110:MSHOH RS08210
gene id: 1434110:MSHOH_RS08210
uniprot id: A0A0E3SB24
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS17215
gene id: 1434110:MSHOH_RS17215
uniprot id: A0A0E3SH13
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1434110:MSHOH RS19550
gene id: 1434110:MSHOH_RS19550
uniprot id: A0A0E3WWS3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

1434110:MSHOH RS03580
gene id: 1434110:MSHOH_RS03580
uniprot id: A0A0E3WSR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1434110:MSHOH RS07030
gene id: 1434110:MSHOH_RS07030
uniprot id: A0A0E3WUE0
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.

1434110:MSHOH RS00575
gene id: 1434110:MSHOH_RS00575
uniprot id: A0A0E3S5X8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

1434110:MSHOH RS02490
gene id: 1434110:MSHOH_RS02490
uniprot id: A0A0E3S6S2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

1434110:MSHOH RS17520
gene id: 1434110:MSHOH_RS17520
uniprot id: A0A0E3SFC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

1434110:MSHOH RS21275
gene id: 1434110:MSHOH_RS21275
uniprot id: A0A0E3WWX1
names: Similarity
messages: Belongs to the aspartokinase family.

1434110:MSHOH RS03225
gene id: 1434110:MSHOH_RS03225
uniprot id: A0A0E3S711
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1434110:MSHOH RS12960
gene id: 1434110:MSHOH_RS12960
uniprot id: A0A0E3WUI4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS05875
gene id: 1434110:MSHOH_RS05875
uniprot id: A0A0E3WVC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

1434110:MSHOH RS04220
gene id: 1434110:MSHOH_RS04220
uniprot id: A0A0E3SD33
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

1434110:MSHOH RS15290
gene id: 1434110:MSHOH_RS15290
uniprot id: A0A0E3SHN6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

1434110:MSHOH RS06070
gene id: 1434110:MSHOH_RS06070
uniprot id: A0A0E3SA40
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

1434110:MSHOH RS13930
gene id: 1434110:MSHOH_RS13930
uniprot id: A0A0E3SDX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

1434110:MSHOH RS00475
gene id: 1434110:MSHOH_RS00475
uniprot id: A0A0E3WSJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

1434110:MSHOH RS11135
gene id: 1434110:MSHOH_RS11135
uniprot id: A0A0E3SCI0
names: Similarity
messages: Belongs to the UPF0228 family.

1434110:MSHOH RS20705
gene id: 1434110:MSHOH_RS20705
uniprot id: A0A0E3SGT8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1434110:MSHOH RS03705
gene id: 1434110:MSHOH_RS03705
uniprot id: A0A0E3WSR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

1434110:MSHOH RS14430
gene id: 1434110:MSHOH_RS14430
uniprot id: A0A0E3SHG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1434110:MSHOH RS19490
gene id: 1434110:MSHOH_RS19490
uniprot id: A0A0E3WUE6
names: Similarity
messages: Belongs to the Ahb/Nir family.

1434110:MSHOH RS00105
gene id: 1434110:MSHOH_RS00105
uniprot id: A0A0E3S5Q8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

1434110:MSHOH RS09465
gene id: 1434110:MSHOH_RS09465
uniprot id: A0A0E3SBM3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1434110:MSHOH RS06740
gene id: 1434110:MSHOH_RS06740
uniprot id: A0A0E3WUC9
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS17450
gene id: 1434110:MSHOH_RS17450
uniprot id: A0A0E3SIF8
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.

1434110:MSHOH RS04260
gene id: 1434110:MSHOH_RS04260
uniprot id: A0A0E3WST1
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

1434110:MSHOH RS06635
gene id: 1434110:MSHOH_RS06635
uniprot id: A0A0E3WTF2
names: Similarity
messages: Belongs to the DMRL synthase family.

1434110:MSHOH RS17225
gene id: 1434110:MSHOH_RS17225
uniprot id: A0A0E3SCK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1434110:MSHOH RS00545
gene id: 1434110:MSHOH_RS00545
uniprot id: A0A0E3SBE3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1434110:MSHOH RS06795
gene id: 1434110:MSHOH_RS06795
uniprot id: A0A0E3S8I2
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS20410
gene id: 1434110:MSHOH_RS20410
uniprot id: A0A0E3SIG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS18660
gene id: 1434110:MSHOH_RS18660
uniprot id: A0A0E3SIT2
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS07450
gene id: 1434110:MSHOH_RS07450
uniprot id: A0A0E3S8R0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1434110:MSHOH RS00095
gene id: 1434110:MSHOH_RS00095
uniprot id: A0A0E3SA35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

1434110:MSHOH RS00865
gene id: 1434110:MSHOH_RS00865
uniprot id: A0A0E3S7V4
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS06050
gene id: 1434110:MSHOH_RS06050
uniprot id: A0A0E3SDS2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

1434110:MSHOH RS15165
gene id: 1434110:MSHOH_RS15165
uniprot id: A0A0E3SBR9
names: Similarity
messages: Belongs to the complex I subunit 3 family.

1434110:MSHOH RS10940
gene id: 1434110:MSHOH_RS10940
uniprot id: A0A0E3SG87
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS00430
gene id: 1434110:MSHOH_RS00430
uniprot id: A0A0E3S7P2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1434110:MSHOH RS14415
gene id: 1434110:MSHOH_RS14415
uniprot id: A0A0E3WUD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

1434110:MSHOH RS03720
gene id: 1434110:MSHOH_RS03720
uniprot id: A0A0E3SCW8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-98 inactivates the nitrogenase reductase and regulates nitrogenase activity.

1434110:MSHOH RS12210
gene id: 1434110:MSHOH_RS12210
uniprot id: A0A0E3WU51
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS09945
gene id: 1434110:MSHOH_RS09945
uniprot id: A0A0E3S9S2
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

1434110:MSHOH RS05230
gene id: 1434110:MSHOH_RS05230
uniprot id: A0A0E3WV98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS12705
gene id: 1434110:MSHOH_RS12705
uniprot id: A0A0E3SGW3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1434110:MSHOH RS06330
gene id: 1434110:MSHOH_RS06330
uniprot id: A0A0E3SA97
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1434110:MSHOH RS09725
gene id: 1434110:MSHOH_RS09725
uniprot id: A0A0E3WTB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1434110:MSHOH RS00285
gene id: 1434110:MSHOH_RS00285
uniprot id: A0A0E3SB94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

1434110:MSHOH RS04900
gene id: 1434110:MSHOH_RS04900
uniprot id: A0A0E3S7N3
names: Similarity
messages: Belongs to the arginase family.

1434110:MSHOH RS17680
gene id: 1434110:MSHOH_RS17680
uniprot id: A0A0E3SII0
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

1434110:MSHOH RS05585
gene id: 1434110:MSHOH_RS05585
uniprot id: A0A0E3SDK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

1434110:MSHOH RS17375
gene id: 1434110:MSHOH_RS17375
uniprot id: A0A0E3SIF1
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1434110:MSHOH RS05955
gene id: 1434110:MSHOH_RS05955
uniprot id: A0A0E3S839
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1434110:MSHOH RS11095
gene id: 1434110:MSHOH_RS11095
uniprot id: A0A0E3SGA8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

1434110:MSHOH RS06300
gene id: 1434110:MSHOH_RS06300
uniprot id: A0A0E3WTY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434110:MSHOH RS12175
gene id: 1434110:MSHOH_RS12175
uniprot id: A0A0E3SGQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1434110:MSHOH RS12340
gene id: 1434110:MSHOH_RS12340
uniprot id: A0A0E3SD72
names: Similarity
messages: Belongs to the oxoprolinase family.

1434110:MSHOH RS08880
gene id: 1434110:MSHOH_RS08880
uniprot id: A0A0E3S9A8
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS14725
gene id: 1434110:MSHOH_RS14725
uniprot id: A0A0E3SBL0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS06430
gene id: 1434110:MSHOH_RS06430
uniprot id: A0A0E3SAB5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS02810
gene id: 1434110:MSHOH_RS02810
uniprot id: A0A0E3S6W9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1434110:MSHOH RS02995
gene id: 1434110:MSHOH_RS02995
uniprot id: A0A0E3SCL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

1434110:MSHOH RS01885
gene id: 1434110:MSHOH_RS01885
uniprot id: A0A0E3SAV0
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS18590
gene id: 1434110:MSHOH_RS18590
uniprot id: A0A0E3SFR1
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

1434110:MSHOH RS19455
gene id: 1434110:MSHOH_RS19455
uniprot id: A0A0E3SIZ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

1434110:MSHOH RS06125
gene id: 1434110:MSHOH_RS06125
uniprot id: A0A0E3SCH0
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS12840
gene id: 1434110:MSHOH_RS12840
uniprot id: A0A0E3SF56
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

1434110:MSHOH RS20240
gene id: 1434110:MSHOH_RS20240
uniprot id: A0A0E3SJ98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

1434110:MSHOH RS00350
gene id: 1434110:MSHOH_RS00350
uniprot id: A0A0E3S5U2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1434110:MSHOH RS03780
gene id: 1434110:MSHOH_RS03780
uniprot id: A0A0E3SBL4
names: Similarity
messages: Belongs to the ZPR1 family.

1434110:MSHOH RS03610
gene id: 1434110:MSHOH_RS03610
uniprot id: A0A0E3S939
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS00385
gene id: 1434110:MSHOH_RS00385
uniprot id: A0A0E3S7N5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS18760
gene id: 1434110:MSHOH_RS18760
uniprot id: A0A0E3SIU2
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS10570
gene id: 1434110:MSHOH_RS10570
uniprot id: A0A0E3SG05
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1434110:MSHOH RS19705
gene id: 1434110:MSHOH_RS19705
uniprot id: A0A0E3SI87
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1434110:MSHOH RS00755
gene id: 1434110:MSHOH_RS00755
uniprot id: A0A0E3S7T8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

1434110:MSHOH RS04445
gene id: 1434110:MSHOH_RS04445
uniprot id: A0A0E3S9F0
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1434110:MSHOH RS14915
gene id: 1434110:MSHOH_RS14915
uniprot id: A0A0E3SHJ7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

1434110:MSHOH RS13165
gene id: 1434110:MSHOH_RS13165
uniprot id: A0A0E3SFA3
names: Similarity
messages: Belongs to the Fur family.

1434110:MSHOH RS16660
gene id: 1434110:MSHOH_RS16660
uniprot id: A0A0E3SGS7
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS04165
gene id: 1434110:MSHOH_RS04165
uniprot id: A0A0E3SD26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1434110:MSHOH RS21585
gene id: 1434110:MSHOH_RS21585
uniprot id: A0A0E3SEE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1434110:MSHOH RS02605
gene id: 1434110:MSHOH_RS02605
uniprot id: A0A0E3SB55
names: Subcellular Location Annotation
messages: Cell membrane

1434110:MSHOH RS06620
gene id: 1434110:MSHOH_RS06620
uniprot id: A0A0E3SCQ4
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1434110:MSHOH RS21770
gene id: 1434110:MSHOH_RS21770
uniprot id: A0A0E3SH68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

1434110:MSHOH RS02325
gene id: 1434110:MSHOH_RS02325
uniprot id: A0A0E3SB06
names: Similarity
messages: Belongs to the P(II) protein family.

1434110:MSHOH RS19335
gene id: 1434110:MSHOH_RS19335
uniprot id: A0A0E3SG29
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

1434110:MSHOH RS21675
gene id: 1434110:MSHOH_RS21675
uniprot id: A0A0E3WWY3
names: Function
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

1434110:MSHOH RS09850
gene id: 1434110:MSHOH_RS09850
uniprot id: A0A0E3SBU8
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS01320
gene id: 1434110:MSHOH_RS01320
uniprot id: A0A0E3WSD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Membrane

1434110:MSHOH RS16710
gene id: 1434110:MSHOH_RS16710
uniprot id: A0A0E3SGT3
names: Similarity
messages: Belongs to the HsdR family.

1434110:MSHOH RS08815
gene id: 1434110:MSHOH_RS08815
uniprot id: A0A0E3SBB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1434110:MSHOH RS15080
gene id: 1434110:MSHOH_RS15080
uniprot id: A0A0E3SG65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1434110:MSHOH RS11845
gene id: 1434110:MSHOH_RS11845
uniprot id: A0A0E3SET6
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

1434110:MSHOH RS20675
gene id: 1434110:MSHOH_RS20675
uniprot id: A0A0E3WUH8
names: Similarity
messages: Belongs to the citrate synthase family.

1434110:MSHOH RS15820
gene id: 1434110:MSHOH_RS15820
uniprot id: A0A0E3WUV3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1434110:MSHOH RS03830
gene id: 1434110:MSHOH_RS03830
uniprot id: A0A0E3SBM2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434110:MSHOH RS16895
gene id: 1434110:MSHOH_RS16895
uniprot id: A0A0E3SGV6
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

1434110:MSHOH RS19590
gene id: 1434110:MSHOH_RS19590
uniprot id: A0A0E3SJ17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1434110:MSHOH RS06230
gene id: 1434110:MSHOH_RS06230
uniprot id: A0A0E3SCJ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1434110:MSHOH RS09470
gene id: 1434110:MSHOH_RS09470
uniprot id: A0A0E3SDS0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1434110:MSHOH RS08580
gene id: 1434110:MSHOH_RS08580
uniprot id: A0A0E3SB77
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

1434110:MSHOH RS15920
gene id: 1434110:MSHOH_RS15920
uniprot id: A0A0E3WWF7
names: Similarity
messages: Belongs to the glutaredoxin family.

1434110:MSHOH RS14400
gene id: 1434110:MSHOH_RS14400
uniprot id: A0A0E3SFX3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1434110:MSHOH RS02380
gene id: 1434110:MSHOH_RS02380
uniprot id: A0A0E3SCC2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

1434110:MSHOH RS00440
gene id: 1434110:MSHOH_RS00440
uniprot id: A0A0E3SBC4
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

1434110:MSHOH RS21030
gene id: 1434110:MSHOH_RS21030
uniprot id: A0A0E3SE62
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1434110:MSHOH RS05190
gene id: 1434110:MSHOH_RS05190
uniprot id: A0A0E3SC41
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

1434110:MSHOH RS03840
gene id: 1434110:MSHOH_RS03840
uniprot id: A0A0E3S785
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1434110:MSHOH RS09025
gene id: 1434110:MSHOH_RS09025
uniprot id: A0A0E3SDK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1434110:MSHOH RS15285
gene id: 1434110:MSHOH_RS15285
uniprot id: A0A0E3SG85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

1434110:MSHOH RS12990
gene id: 1434110:MSHOH_RS12990
uniprot id: A0A0E3SDK9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS04110
gene id: 1434110:MSHOH_RS04110
uniprot id: A0A0E3SD20
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

1434110:MSHOH RS16670
gene id: 1434110:MSHOH_RS16670
uniprot id: A0A0E3SCA9
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS06630
gene id: 1434110:MSHOH_RS06630
uniprot id: A0A0E3S8F8
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1434110:MSHOH RS19380
gene id: 1434110:MSHOH_RS19380
uniprot id: A0A0E3SDG3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1434110:MSHOH RS14350
gene id: 1434110:MSHOH_RS14350
uniprot id: A0A0E3SBF0
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS17920
gene id: 1434110:MSHOH_RS17920
uniprot id: A0A0E3SHB0
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS02585
gene id: 1434110:MSHOH_RS02585
uniprot id: A0A0E3SCF3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1434110:MSHOH RS17235
gene id: 1434110:MSHOH_RS17235
uniprot id: A0A0E3SF87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1434110:MSHOH RS00280
gene id: 1434110:MSHOH_RS00280
uniprot id: A0A0E3SA60
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

1434110:MSHOH RS09910
gene id: 1434110:MSHOH_RS09910
uniprot id: A0A0E3SFQ6
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS21375
gene id: 1434110:MSHOH_RS21375
uniprot id: A0A0E3SH15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

1434110:MSHOH RS04095
gene id: 1434110:MSHOH_RS04095
uniprot id: A0A0E3WTU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

1434110:MSHOH RS12455
gene id: 1434110:MSHOH_RS12455
uniprot id: A0A0E3SF01
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS15630
gene id: 1434110:MSHOH_RS15630
uniprot id: A0A0E3SGC5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS08515
gene id: 1434110:MSHOH_RS08515
uniprot id: A0A0E3S959
names: Similarity
messages: Belongs to the pirin family.

1434110:MSHOH RS08985
gene id: 1434110:MSHOH_RS08985
uniprot id: A0A0E3WVP0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1434110:MSHOH RS04515
gene id: 1434110:MSHOH_RS04515
uniprot id: A0A0E3S7H9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1434110:MSHOH RS00375
gene id: 1434110:MSHOH_RS00375
uniprot id: A0A0E3S5U6
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS07325
gene id: 1434110:MSHOH_RS07325
uniprot id: A0A0E3SAL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1434110:MSHOH RS22225
gene id: 1434110:MSHOH_RS22225
uniprot id: A0A0E3SF89
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1434110:MSHOH RS02635
gene id: 1434110:MSHOH_RS02635
uniprot id: A0A0E3SCG1
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS19135
gene id: 1434110:MSHOH_RS19135
uniprot id: A0A0E3SIJ8
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

1434110:MSHOH RS01860
gene id: 1434110:MSHOH_RS01860
uniprot id: A0A0E3SC21
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434110:MSHOH RS04975
gene id: 1434110:MSHOH_RS04975
uniprot id: A0A0E3S7P5
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS21740
gene id: 1434110:MSHOH_RS21740
uniprot id: A0A0E3SEG6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1434110:MSHOH RS13360
gene id: 1434110:MSHOH_RS13360
uniprot id: A0A0E3SFG9
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS03500
gene id: 1434110:MSHOH_RS03500
uniprot id: A0A0E3WT32
names: Similarity
messages: Belongs to the DEAD box helicase family.

1434110:MSHOH RS22020
gene id: 1434110:MSHOH_RS22020
uniprot id: A0A0E3SAE8
names: Subcellular Location Annotation
messages: Cell inner membrane

1434110:MSHOH RS02555
gene id: 1434110:MSHOH_RS02555
uniprot id: A0A0E3SB46
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS01340
gene id: 1434110:MSHOH_RS01340
uniprot id: A0A0E3SBR8
names: Similarity
messages: Belongs to the HepT RNase toxin family.

1434110:MSHOH RS03335
gene id: 1434110:MSHOH_RS03335
uniprot id: A0A0E3SCQ5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

1434110:MSHOH RS13120
gene id: 1434110:MSHOH_RS13120
uniprot id: A0A0E3SAY1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.

1434110:MSHOH RS18135
gene id: 1434110:MSHOH_RS18135
uniprot id: A0A0E3SCZ0
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1434110:MSHOH RS15490
gene id: 1434110:MSHOH_RS15490
uniprot id: A0A0E3SEJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1434110:MSHOH RS03985
gene id: 1434110:MSHOH_RS03985
uniprot id: A0A0E3SBP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1434110:MSHOH RS06155
gene id: 1434110:MSHOH_RS06155
uniprot id: A0A0E3SCH3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1434110:MSHOH RS16540
gene id: 1434110:MSHOH_RS16540
uniprot id: A0A0E3SC86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1434110:MSHOH RS07690
gene id: 1434110:MSHOH_RS07690
uniprot id: A0A0E3SAV5
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS12925
gene id: 1434110:MSHOH_RS12925
uniprot id: A0A0E3SGY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS15050
gene id: 1434110:MSHOH_RS15050
uniprot id: A0A0E3SED8
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

1434110:MSHOH RS10130
gene id: 1434110:MSHOH_RS10130
uniprot id: A0A0E3WUN2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1434110:MSHOH RS04010
gene id: 1434110:MSHOH_RS04010
uniprot id: A0A0E3SBP8
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

1434110:MSHOH RS04995
gene id: 1434110:MSHOH_RS04995
uniprot id: A0A0E3SDC5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

1434110:MSHOH RS19070
gene id: 1434110:MSHOH_RS19070
uniprot id: A0A0E3SHT1
names: Similarity
messages: Belongs to the eIF-2-alpha family.

1434110:MSHOH RS17250
gene id: 1434110:MSHOH_RS17250
uniprot id: A0A0E3SCK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

1434110:MSHOH RS06650
gene id: 1434110:MSHOH_RS06650
uniprot id: A0A0E3SE45
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS19340
gene id: 1434110:MSHOH_RS19340
uniprot id: A0A0E3SI00
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS11300
gene id: 1434110:MSHOH_RS11300
uniprot id: A0A0E3SA98
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1434110:MSHOH RS01840
gene id: 1434110:MSHOH_RS01840
uniprot id: A0A0E3S6I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS20895
gene id: 1434110:MSHOH_RS20895
uniprot id: A0A0E3WWW1
names: Similarity
messages: Belongs to the HerA family.

1434110:MSHOH RS15825
gene id: 1434110:MSHOH_RS15825
uniprot id: A0A0E3SEP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1434110:MSHOH RS21355
gene id: 1434110:MSHOH_RS21355
uniprot id: A0A0E3SIT6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

1434110:MSHOH RS08875
gene id: 1434110:MSHOH_RS08875
uniprot id: A0A0E3SF99
names: Similarity
messages: Belongs to the LOR family.

1434110:MSHOH RS01330
gene id: 1434110:MSHOH_RS01330
uniprot id: A0A0E3S841
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

1434110:MSHOH RS13320
gene id: 1434110:MSHOH_RS13320
uniprot id: A0A0E3WU93
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

1434110:MSHOH RS18190
gene id: 1434110:MSHOH_RS18190
uniprot id: A0A0E3SCZ9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

1434110:MSHOH RS00640
gene id: 1434110:MSHOH_RS00640
uniprot id: A0A0E3SBF6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

1434110:MSHOH RS08800
gene id: 1434110:MSHOH_RS08800
uniprot id: A0A0E3SF86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1434110:MSHOH RS14610
gene id: 1434110:MSHOH_RS14610
uniprot id: A0A0E3SHG8
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS13510
gene id: 1434110:MSHOH_RS13510
uniprot id: A0A0E3SH41
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1434110:MSHOH RS17435
gene id: 1434110:MSHOH_RS17435
uniprot id: A0A0E3WUS4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

1434110:MSHOH RS10425
gene id: 1434110:MSHOH_RS10425
uniprot id: A0A0E3SE53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1434110:MSHOH RS00510
gene id: 1434110:MSHOH_RS00510
uniprot id: A0A0E3SA92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1434110:MSHOH RS16350
gene id: 1434110:MSHOH_RS16350
uniprot id: A0A0E3SI10
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS06680
gene id: 1434110:MSHOH_RS06680
uniprot id: A0A0E3S8G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1434110:MSHOH RS13425
gene id: 1434110:MSHOH_RS13425
uniprot id: A0A0E3SH31
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS00415
gene id: 1434110:MSHOH_RS00415
uniprot id: A0A0E3SBC0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

1434110:MSHOH RS09720
gene id: 1434110:MSHOH_RS09720
uniprot id: A0A0E3S9P3
names: Similarity
messages: Belongs to the TrpC family.

1434110:MSHOH RS18400
gene id: 1434110:MSHOH_RS18400
uniprot id: A0A0E3SD25
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS15115
gene id: 1434110:MSHOH_RS15115
uniprot id: A0A0E3SBR2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

1434110:MSHOH RS16550
gene id: 1434110:MSHOH_RS16550
uniprot id: A0A0E3SEX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

1434110:MSHOH RS02495
gene id: 1434110:MSHOH_RS02495
uniprot id: A0A0E3WSM5
names: Similarity
messages: Belongs to the AOR/FOR family.

1434110:MSHOH RS08605
gene id: 1434110:MSHOH_RS08605
uniprot id: A0A0E3SB81
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

1434110:MSHOH RS09070
gene id: 1434110:MSHOH_RS09070
uniprot id: A0A0E3SBH4
names: Similarity
messages: Belongs to the HerA family.

1434110:MSHOH RS15480
gene id: 1434110:MSHOH_RS15480
uniprot id: A0A0E3SBV7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1434110:MSHOH RS10320
gene id: 1434110:MSHOH_RS10320
uniprot id: A0A0E3SE40
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

1434110:MSHOH RS10965
gene id: 1434110:MSHOH_RS10965
uniprot id: A0A0E3SG90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

1434110:MSHOH RS03140
gene id: 1434110:MSHOH_RS03140
uniprot id: A0A0E3S8U6
names: Similarity
messages: Belongs to the AAA ATPase family.

1434110:MSHOH RS25175
gene id: 1434110:MSHOH_RS25175
uniprot id: A0A0E3WTS5
names: Similarity
messages: Belongs to the myoviridae tail sheath protein family.

1434110:MSHOH RS03120
gene id: 1434110:MSHOH_RS03120
uniprot id: A0A0E3SBC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

1434110:MSHOH RS20810
gene id: 1434110:MSHOH_RS20810
uniprot id: A0A0E3SGV2
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

1434110:MSHOH RS01490
gene id: 1434110:MSHOH_RS01490
uniprot id: A0A0E3S860
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1434110:MSHOH RS04520
gene id: 1434110:MSHOH_RS04520
uniprot id: A0A0E3WSU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1434110:MSHOH RS03850
gene id: 1434110:MSHOH_RS03850
uniprot id: A0A0E3S993
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

1434110:MSHOH RS15095
gene id: 1434110:MSHOH_RS15095
uniprot id: A0A0E3WV84
names: Function
messages: Part of a potassium transport system.

1434110:MSHOH RS17570
gene id: 1434110:MSHOH_RS17570
uniprot id: A0A0E3SFC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1434110:MSHOH RS14240
gene id: 1434110:MSHOH_RS14240
uniprot id: A0A0E3WTR0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS18820
gene id: 1434110:MSHOH_RS18820
uniprot id: A0A0E3SD90
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS00540
gene id: 1434110:MSHOH_RS00540
uniprot id: A0A0E3SA96
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1434110:MSHOH RS05050
gene id: 1434110:MSHOH_RS05050
uniprot id: A0A0E3WU66
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

1434110:MSHOH RS21400
gene id: 1434110:MSHOH_RS21400
uniprot id: A0A0E3SIX1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS03805
gene id: 1434110:MSHOH_RS03805
uniprot id: A0A0E3SBL8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

1434110:MSHOH RS12760
gene id: 1434110:MSHOH_RS12760
uniprot id: A0A0E3SDI6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1434110:MSHOH RS09745
gene id: 1434110:MSHOH_RS09745
uniprot id: A0A0E3S9P7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

1434110:MSHOH RS19360
gene id: 1434110:MSHOH_RS19360
uniprot id: A0A0E3SG33
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1434110:MSHOH RS10575
gene id: 1434110:MSHOH_RS10575
uniprot id: A0A0E3SA08
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

1434110:MSHOH RS20555
gene id: 1434110:MSHOH_RS20555
uniprot id: A0A0E3SJD3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

1434110:MSHOH RS17195
gene id: 1434110:MSHOH_RS17195
uniprot id: A0A0E3SID2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1434110:MSHOH RS20465
gene id: 1434110:MSHOH_RS20465
uniprot id: A0A0E3WV31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1434110:MSHOH RS16885
gene id: 1434110:MSHOH_RS16885
uniprot id: A0A0E3WVE4
names: Similarity
messages: Belongs to the HupF/HypC family.

1434110:MSHOH RS16310
gene id: 1434110:MSHOH_RS16310
uniprot id: A0A0E3SEU7
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

1434110:MSHOH RS21350
gene id: 1434110:MSHOH_RS21350
uniprot id: A0A0E3SH11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

1434110:MSHOH RS17110
gene id: 1434110:MSHOH_RS17110
uniprot id: A0A0E3SF71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

1434110:MSHOH RS17150
gene id: 1434110:MSHOH_RS17150
uniprot id: A0A0E3SCJ2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1434110:MSHOH RS00290
gene id: 1434110:MSHOH_RS00290
uniprot id: A0A0E3S5T3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1434110:MSHOH RS17585
gene id: 1434110:MSHOH_RS17585
uniprot id: A0A0E3SIH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

1434110:MSHOH RS04380
gene id: 1434110:MSHOH_RS04380
uniprot id: A0A0E3SD52
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

1434110:MSHOH RS04405
gene id: 1434110:MSHOH_RS04405
uniprot id: A0A0E3SD56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1434110:MSHOH RS14735
gene id: 1434110:MSHOH_RS14735
uniprot id: A0A0E3SEA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1434110:MSHOH RS05815
gene id: 1434110:MSHOH_RS05815
uniprot id: A0A0E3SA07
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1434110:MSHOH RS17505
gene id: 1434110:MSHOH_RS17505
uniprot id: A0A0E3SCP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

1434110:MSHOH RS01475
gene id: 1434110:MSHOH_RS01475
uniprot id: A0A0E3SBU3
names: Subcellular Location Annotation
messages: Membrane

1434110:MSHOH RS17865
gene id: 1434110:MSHOH_RS17865
uniprot id: A0A0E3SFF7
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1434110:MSHOH RS06225
gene id: 1434110:MSHOH_RS06225
uniprot id: A0A0E3SA63
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1434110:MSHOH RS17720
gene id: 1434110:MSHOH_RS17720
uniprot id: A0A0E3SFE2
names: Similarity
messages: Belongs to the band 7/mec-2 family.

1434110:MSHOH RS19495
gene id: 1434110:MSHOH_RS19495
uniprot id: A0A0E3SG78
names: Similarity
messages: Belongs to the Ahb/Nir family.