1407499:HHUB RS12740
gene id: 1407499:HHUB_RS12740
uniprot id: A0A0U5HXJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

1407499:HHUB RS10530
gene id: 1407499:HHUB_RS10530
uniprot id: A0A0U5D052
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

1407499:HHUB RS13070
gene id: 1407499:HHUB_RS13070
uniprot id: A0A0U5H5B1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1407499:HHUB RS04725
gene id: 1407499:HHUB_RS04725
uniprot id: A0A0U5H213
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

1407499:HHUB RS01180
gene id: 1407499:HHUB_RS01180
uniprot id: A0A0U5GXG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

1407499:HHUB RS07970
gene id: 1407499:HHUB_RS07970
uniprot id: A0A0U5H4X9
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group I subfamily.

1407499:HHUB RS10320
gene id: 1407499:HHUB_RS10320
uniprot id: A0A0U5H7F7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

1407499:HHUB RS07780
gene id: 1407499:HHUB_RS07780
uniprot id: A0A0U5H108
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

1407499:HHUB RS08755
gene id: 1407499:HHUB_RS08755
uniprot id: A0A0U5H471
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

1407499:HHUB RS09320
gene id: 1407499:HHUB_RS09320
uniprot id: A0A0U5H327
names: Function
messages: Part of a potassium transport system.

1407499:HHUB RS10390
gene id: 1407499:HHUB_RS10390
uniprot id: A0A0U5D032
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

1407499:HHUB RS00030
gene id: 1407499:HHUB_RS00030
uniprot id: A0A0U5GZ94
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS09585
gene id: 1407499:HHUB_RS09585
uniprot id: A0A0U5HVS3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

1407499:HHUB RS11615
gene id: 1407499:HHUB_RS11615
uniprot id: A0A0U5H5W0
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

1407499:HHUB RS08600
gene id: 1407499:HHUB_RS08600
uniprot id: A0A0U5H437
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

1407499:HHUB RS09605
gene id: 1407499:HHUB_RS09605
uniprot id: A0A0U5H5W4
names: Similarity
messages: Belongs to the PspA/IM30 family.

1407499:HHUB RS14410
gene id: 1407499:HHUB_RS14410
uniprot id: A0A0U5AJZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1407499:HHUB RS08500
gene id: 1407499:HHUB_RS08500
uniprot id: A0A0U5H1D9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

1407499:HHUB RS03490
gene id: 1407499:HHUB_RS03490
uniprot id: A0A0U5GYU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADH dehydrogenase family.
messages: Cytoplasm

1407499:HHUB RS02970
gene id: 1407499:HHUB_RS02970
uniprot id: A0A0U5CW36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

1407499:HHUB RS01505
gene id: 1407499:HHUB_RS01505
uniprot id: A0A0U5H3H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

1407499:HHUB RS09100
gene id: 1407499:HHUB_RS09100
uniprot id: A0A0U5CZD4
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

1407499:HHUB RS05880
gene id: 1407499:HHUB_RS05880
uniprot id: A0A0U5H3N7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

1407499:HHUB RS01185
gene id: 1407499:HHUB_RS01185
uniprot id: A0A0U5GXM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1407499:HHUB RS05145
gene id: 1407499:HHUB_RS05145
uniprot id: A0A0U5CXA4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS02230
gene id: 1407499:HHUB_RS02230
uniprot id: A0A0U5H3X9
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

1407499:HHUB RS02240
gene id: 1407499:HHUB_RS02240
uniprot id: A0A0U5GY01
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

1407499:HHUB RS04895
gene id: 1407499:HHUB_RS04895
uniprot id: A0A0U5HT49
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1407499:HHUB RS12220
gene id: 1407499:HHUB_RS12220
uniprot id: A0A0U5D143
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

1407499:HHUB RS01855
gene id: 1407499:HHUB_RS01855
uniprot id: A0A0U5H2B9
names: Similarity
messages: Belongs to the UPF0440 family.

1407499:HHUB RS08820
gene id: 1407499:HHUB_RS08820
uniprot id: A0A0U5HVB6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

1407499:HHUB RS12690
gene id: 1407499:HHUB_RS12690
uniprot id: A0A0U5D129
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

1407499:HHUB RS11385
gene id: 1407499:HHUB_RS11385
uniprot id: A0A0U5H4V9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

1407499:HHUB RS01120
gene id: 1407499:HHUB_RS01120
uniprot id: A0A0U5AAI1
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

1407499:HHUB RS03500
gene id: 1407499:HHUB_RS03500
uniprot id: A0A0U5HSD9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

1407499:HHUB RS08505
gene id: 1407499:HHUB_RS08505
uniprot id: A0A0U5H3L4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

1407499:HHUB RS13705
gene id: 1407499:HHUB_RS13705
uniprot id: A0A0U5H746
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1407499:HHUB RS08825
gene id: 1407499:HHUB_RS08825
uniprot id: A0A0U5AFV7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1407499:HHUB RS06085
gene id: 1407499:HHUB_RS06085
uniprot id: A0A0U5HTT2
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS09460
gene id: 1407499:HHUB_RS09460
uniprot id: A0A0U5CZG0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1407499:HHUB RS07580
gene id: 1407499:HHUB_RS07580
uniprot id: A0A0U5H4P7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1407499:HHUB RS06330
gene id: 1407499:HHUB_RS06330
uniprot id: A0A0U5H299
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS10650
gene id: 1407499:HHUB_RS10650
uniprot id: A0A0U5HWD4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS00080
gene id: 1407499:HHUB_RS00080
uniprot id: A0A0U5GX23
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

1407499:HHUB RS04930
gene id: 1407499:HHUB_RS04930
uniprot id: A0A0U5CXI1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1407499:HHUB RS05255
gene id: 1407499:HHUB_RS05255
uniprot id: A0A0U5GZP7
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS13685
gene id: 1407499:HHUB_RS13685
uniprot id: A0A0U5H6Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1407499:HHUB RS03025
gene id: 1407499:HHUB_RS03025
uniprot id: A0A0U5HS61
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1407499:HHUB RS05470
gene id: 1407499:HHUB_RS05470
uniprot id: A0A0U5H3I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

1407499:HHUB RS02170
gene id: 1407499:HHUB_RS02170
uniprot id: A0A0U5GY50
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

1407499:HHUB RS11570
gene id: 1407499:HHUB_RS11570
uniprot id: A0A0U5D0P4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS04850
gene id: 1407499:HHUB_RS04850
uniprot id: A0A0U5CX48
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

1407499:HHUB RS03600
gene id: 1407499:HHUB_RS03600
uniprot id: A0A0U5CWK0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS14700
gene id: 1407499:HHUB_RS14700
uniprot id: A0A0U5H7G6
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS12595
gene id: 1407499:HHUB_RS12595
uniprot id: A0A0U5H5J8
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS01945
gene id: 1407499:HHUB_RS01945
uniprot id: A0A0U5H0B1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS06710
gene id: 1407499:HHUB_RS06710
uniprot id: A0A0U5HU53
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1407499:HHUB RS06485
gene id: 1407499:HHUB_RS06485
uniprot id: A0A0U5H0A7
names: Similarity
messages: Belongs to the DNA photolyase family.

1407499:HHUB RS13425
gene id: 1407499:HHUB_RS13425
uniprot id: A0A0U5HAN3
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS08720
gene id: 1407499:HHUB_RS08720
uniprot id: A0A0U5H7W2
names: Similarity
messages: Belongs to the archease family.

1407499:HHUB RS11235
gene id: 1407499:HHUB_RS11235
uniprot id: A0A0U5H6Z3
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

1407499:HHUB RS09665
gene id: 1407499:HHUB_RS09665
uniprot id: A0A0U5HVT2
names: Similarity
messages: Belongs to the MoaB/Mog family.

1407499:HHUB RS09405
gene id: 1407499:HHUB_RS09405
uniprot id: A0A0U5H6T6
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

1407499:HHUB RS02870
gene id: 1407499:HHUB_RS02870
uniprot id: A0A0U5ABR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1407499:HHUB RS11240
gene id: 1407499:HHUB_RS11240
uniprot id: A0A0U5D0I2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

1407499:HHUB RS07325
gene id: 1407499:HHUB_RS07325
uniprot id: A0A0U5HUH2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1407499:HHUB RS08090
gene id: 1407499:HHUB_RS08090
uniprot id: A0A0U5H427
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1407499:HHUB RS11955
gene id: 1407499:HHUB_RS11955
uniprot id: A0A0U5D0Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1407499:HHUB RS03780
gene id: 1407499:HHUB_RS03780
uniprot id: A0A0U5H2M3
names: Similarity
messages: Belongs to the DtxR/MntR family.

1407499:HHUB RS04810
gene id: 1407499:HHUB_RS04810
uniprot id: A0A0U5H234
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1407499:HHUB RS11315
gene id: 1407499:HHUB_RS11315
uniprot id: A0A0U5H700
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

1407499:HHUB RS03420
gene id: 1407499:HHUB_RS03420
uniprot id: A0A0U5HSC3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS13260
gene id: 1407499:HHUB_RS13260
uniprot id: A0A0U5H766
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS09530
gene id: 1407499:HHUB_RS09530
uniprot id: A0A0U5CZN5
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

1407499:HHUB RS12700
gene id: 1407499:HHUB_RS12700
uniprot id: A0A0U5D179
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1407499:HHUB RS04905
gene id: 1407499:HHUB_RS04905
uniprot id: A0A0U5H0Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1407499:HHUB RS10325
gene id: 1407499:HHUB_RS10325
uniprot id: A0A0U5H8V4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1407499:HHUB RS12600
gene id: 1407499:HHUB_RS12600
uniprot id: A0A0U5H6H2
names: Similarity
messages: Belongs to the Dps family.

1407499:HHUB RS06995
gene id: 1407499:HHUB_RS06995
uniprot id: A0A0U5H0M0
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

1407499:HHUB RS04735
gene id: 1407499:HHUB_RS04735
uniprot id: A0A0U5GZF3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS05415
gene id: 1407499:HHUB_RS05415
uniprot id: A0A0U5GZS1
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS09915
gene id: 1407499:HHUB_RS09915
uniprot id: A0A0U5H4W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

1407499:HHUB RS01615
gene id: 1407499:HHUB_RS01615
uniprot id: A0A0U5GXU7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

1407499:HHUB RS12195
gene id: 1407499:HHUB_RS12195
uniprot id: A0A0U5HX94
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1407499:HHUB RS12930
gene id: 1407499:HHUB_RS12930
uniprot id: A0A0U5H7T0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

1407499:HHUB RS08395
gene id: 1407499:HHUB_RS08395
uniprot id: A0A0U5H655
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1407499:HHUB RS07995
gene id: 1407499:HHUB_RS07995
uniprot id: A0A0U5CYX4
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1407499:HHUB RS09950
gene id: 1407499:HHUB_RS09950
uniprot id: A0A0U5H8M3
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

1407499:HHUB RS11885
gene id: 1407499:HHUB_RS11885
uniprot id: A0A0U5D0Q0
names: Similarity
messages: Belongs to the MCM family.

1407499:HHUB RS11050
gene id: 1407499:HHUB_RS11050
uniprot id: A0A0U5H543
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1407499:HHUB RS10880
gene id: 1407499:HHUB_RS10880
uniprot id: A0A0U5H5T4
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

1407499:HHUB RS14885
gene id: 1407499:HHUB_RS14885
uniprot id: A0A0U5HBL5
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS02825
gene id: 1407499:HHUB_RS02825
uniprot id: A0A0U5CW96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

1407499:HHUB RS11550
gene id: 1407499:HHUB_RS11550
uniprot id: A0A0U5H744
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

1407499:HHUB RS07345
gene id: 1407499:HHUB_RS07345
uniprot id: A0A0U5H3C1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS12200
gene id: 1407499:HHUB_RS12200
uniprot id: A0A0U5AIL0
names: Similarity
messages: Belongs to the HMBS family.

1407499:HHUB RS12385
gene id: 1407499:HHUB_RS12385
uniprot id: A0A0U5H4W9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

1407499:HHUB RS13090
gene id: 1407499:HHUB_RS13090
uniprot id: A0A0U5HAG9
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS09325
gene id: 1407499:HHUB_RS09325
uniprot id: A0A0U5CZK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

1407499:HHUB RS08425
gene id: 1407499:HHUB_RS08425
uniprot id: A0A0U5H3J5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1407499:HHUB RS12735
gene id: 1407499:HHUB_RS12735
uniprot id: A0A0U5H661
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

1407499:HHUB RS05375
gene id: 1407499:HHUB_RS05375
uniprot id: A0A0U5CXH3
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS02420
gene id: 1407499:HHUB_RS02420
uniprot id: A0A0U5GZL1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1407499:HHUB RS13080
gene id: 1407499:HHUB_RS13080
uniprot id: A0A0U5H7W3
names: Similarity
messages: Belongs to the aspartokinase family.

1407499:HHUB RS03395
gene id: 1407499:HHUB_RS03395
uniprot id: A0A0U5H4P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

1407499:HHUB RS05810
gene id: 1407499:HHUB_RS05810
uniprot id: A0A0U5CXP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

1407499:HHUB RS03690
gene id: 1407499:HHUB_RS03690
uniprot id: A0A0U5GZX7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

1407499:HHUB RS10270
gene id: 1407499:HHUB_RS10270
uniprot id: A0A0U5HW67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1407499:HHUB RS07425
gene id: 1407499:HHUB_RS07425
uniprot id: A0A0U5H4K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

1407499:HHUB RS10520
gene id: 1407499:HHUB_RS10520
uniprot id: A0A0U5H584
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1407499:HHUB RS05875
gene id: 1407499:HHUB_RS05875
uniprot id: A0A0U5H2H7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS04995
gene id: 1407499:HHUB_RS04995
uniprot id: A0A0U5CXC3
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

1407499:HHUB RS11690
gene id: 1407499:HHUB_RS11690
uniprot id: A0A0U5H524
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Brp/Blh beta-carotene diooxygenase family.
messages: Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal.
messages: Cell membrane

1407499:HHUB RS02540
gene id: 1407499:HHUB_RS02540
uniprot id: A0A0U5H0Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

1407499:HHUB RS02155
gene id: 1407499:HHUB_RS02155
uniprot id: A0A0U5H3W2
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

1407499:HHUB RS08695
gene id: 1407499:HHUB_RS08695
uniprot id: A0A0U5CZ35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1407499:HHUB RS04900
gene id: 1407499:HHUB_RS04900
uniprot id: A0A0U5ADG6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

1407499:HHUB RS03695
gene id: 1407499:HHUB_RS03695
uniprot id: A0A0U5CWV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1407499:HHUB RS11070
gene id: 1407499:HHUB_RS11070
uniprot id: A0A0U5H5L3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

1407499:HHUB RS04825
gene id: 1407499:HHUB_RS04825
uniprot id: A0A0U5HT33
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1407499:HHUB RS12920
gene id: 1407499:HHUB_RS12920
uniprot id: A0A0U5D170
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

1407499:HHUB RS04360
gene id: 1407499:HHUB_RS04360
uniprot id: A0A0U5H1L1
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

1407499:HHUB RS13095
gene id: 1407499:HHUB_RS13095
uniprot id: A0A0U5H732
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS01720
gene id: 1407499:HHUB_RS01720
uniprot id: A0A0U5H047
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

1407499:HHUB RS11160
gene id: 1407499:HHUB_RS11160
uniprot id: A0A0U5D090
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1407499:HHUB RS04970
gene id: 1407499:HHUB_RS04970
uniprot id: A0A0U5ADI5
names: Subcellular Location Annotation
messages: Cell membrane

1407499:HHUB RS11655
gene id: 1407499:HHUB_RS11655
uniprot id: A0A0U5H9L1
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS14400
gene id: 1407499:HHUB_RS14400
uniprot id: A0A0U5H794
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS00075
gene id: 1407499:HHUB_RS00075
uniprot id: A0A0U5GWU2
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: The active site is a redox-active disulfide bond.

1407499:HHUB RS13100
gene id: 1407499:HHUB_RS13100
uniprot id: A0A0U5H466
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS02365
gene id: 1407499:HHUB_RS02365
uniprot id: A0A0U5GZ66
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

1407499:HHUB RS00245
gene id: 1407499:HHUB_RS00245
uniprot id: A0A0U5H1D4
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS12070
gene id: 1407499:HHUB_RS12070
uniprot id: A0A0U5H7E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1407499:HHUB RS00255
gene id: 1407499:HHUB_RS00255
uniprot id: A0A0U5GZF1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

1407499:HHUB RS02800
gene id: 1407499:HHUB_RS02800
uniprot id: A0A0U5GZT3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1407499:HHUB RS07820
gene id: 1407499:HHUB_RS07820
uniprot id: A0A0U5CYR4
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS13385
gene id: 1407499:HHUB_RS13385
uniprot id: A0A0U5H6Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

1407499:HHUB RS02700
gene id: 1407499:HHUB_RS02700
uniprot id: A0A0U5GYD7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

1407499:HHUB RS07045
gene id: 1407499:HHUB_RS07045
uniprot id: A0A0U5H1S7
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

1407499:HHUB RS08945
gene id: 1407499:HHUB_RS08945
uniprot id: A0A0U5H5G5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS06225
gene id: 1407499:HHUB_RS06225
uniprot id: A0A0U5H6D6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

1407499:HHUB RS15290
gene id: 1407499:HHUB_RS15290
uniprot id: A0A0U5D2Y0
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

1407499:HHUB RS05365
gene id: 1407499:HHUB_RS05365
uniprot id: A0A0U5H3C9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1407499:HHUB RS12710
gene id: 1407499:HHUB_RS12710
uniprot id: A0A0U5H8Z3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

1407499:HHUB RS02135
gene id: 1407499:HHUB_RS02135
uniprot id: A0A0U5GZ12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

1407499:HHUB RS07560
gene id: 1407499:HHUB_RS07560
uniprot id: A0A0U5HUM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

1407499:HHUB RS06660
gene id: 1407499:HHUB_RS06660
uniprot id: A0A0U5CY50
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1407499:HHUB RS07180
gene id: 1407499:HHUB_RS07180
uniprot id: A0A0U5H293
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

1407499:HHUB RS10840
gene id: 1407499:HHUB_RS10840
uniprot id: A0A0U5H6P4
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1407499:HHUB RS12455
gene id: 1407499:HHUB_RS12455
uniprot id: A0A0U5D177
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS10890
gene id: 1407499:HHUB_RS10890
uniprot id: A0A0U5H2Q8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

1407499:HHUB RS11515
gene id: 1407499:HHUB_RS11515
uniprot id: A0A0U5H383
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

1407499:HHUB RS07985
gene id: 1407499:HHUB_RS07985
uniprot id: A0A0U5CYT8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1407499:HHUB RS06605
gene id: 1407499:HHUB_RS06605
uniprot id: A0A0U5CY39
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS00320
gene id: 1407499:HHUB_RS00320
uniprot id: A0A0U5H0F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1407499:HHUB RS11075
gene id: 1407499:HHUB_RS11075
uniprot id: A0A0U5H6U3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

1407499:HHUB RS15875
gene id: 1407499:HHUB_RS15875
uniprot id: A0A0U5H5P0
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS08455
gene id: 1407499:HHUB_RS08455
uniprot id: A0A0U5CZ24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Homodimer.

1407499:HHUB RS00050
gene id: 1407499:HHUB_RS00050
uniprot id: A0A0U5GXV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1407499:HHUB RS07585
gene id: 1407499:HHUB_RS07585
uniprot id: A0A0U5CYL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1407499:HHUB RS09540
gene id: 1407499:HHUB_RS09540
uniprot id: A0A0U5H370
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1407499:HHUB RS08440
gene id: 1407499:HHUB_RS08440
uniprot id: A0A0U5H303
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

1407499:HHUB RS01145
gene id: 1407499:HHUB_RS01145
uniprot id: A0A0U5CVH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

1407499:HHUB RS09275
gene id: 1407499:HHUB_RS09275
uniprot id: A0A0U5H1V0
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

1407499:HHUB RS11920
gene id: 1407499:HHUB_RS11920
uniprot id: A0A0U5H3G7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

1407499:HHUB RS01665
gene id: 1407499:HHUB_RS01665
uniprot id: A0A0U5CVJ2
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS08670
gene id: 1407499:HHUB_RS08670
uniprot id: A0A0U5AFS5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

1407499:HHUB RS10190
gene id: 1407499:HHUB_RS10190
uniprot id: A0A0U5HW50
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

1407499:HHUB RS12705
gene id: 1407499:HHUB_RS12705
uniprot id: A0A0U5H7M7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1407499:HHUB RS12950
gene id: 1407499:HHUB_RS12950
uniprot id: A0A0U5H3V0
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1407499:HHUB RS11100
gene id: 1407499:HHUB_RS11100
uniprot id: A0A0U5H6M9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS07280
gene id: 1407499:HHUB_RS07280
uniprot id: A0A0U5H1X8
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1407499:HHUB RS04655
gene id: 1407499:HHUB_RS04655
uniprot id: A0A0U5GZE1
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

1407499:HHUB RS11245
gene id: 1407499:HHUB_RS11245
uniprot id: A0A0U5D0A4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

1407499:HHUB RS12560
gene id: 1407499:HHUB_RS12560
uniprot id: A0A0U5H8W2
names: Similarity
messages: Belongs to the UPF0200 family.

1407499:HHUB RS04775
gene id: 1407499:HHUB_RS04775
uniprot id: A0A0U5CX35
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

1407499:HHUB RS11065
gene id: 1407499:HHUB_RS11065
uniprot id: A0A0U5H4N6
names: Similarity
messages: Belongs to the PDCD5 family.

1407499:HHUB RS08305
gene id: 1407499:HHUB_RS08305
uniprot id: A0A0U5H533
names: Similarity
messages: Belongs to the AOR/FOR family.

1407499:HHUB RS03270
gene id: 1407499:HHUB_RS03270
uniprot id: A0A0U5AC14
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

1407499:HHUB RS10065
gene id: 1407499:HHUB_RS10065
uniprot id: A0A0U5AGY9
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS03720
gene id: 1407499:HHUB_RS03720
uniprot id: A0A0U5GYS8
names: Similarity
messages: Belongs to the threonine synthase family.

1407499:HHUB RS01420
gene id: 1407499:HHUB_RS01420
uniprot id: A0A0U5GXJ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS07835
gene id: 1407499:HHUB_RS07835
uniprot id: A0A0U5H4U7
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS01990
gene id: 1407499:HHUB_RS01990
uniprot id: A0A0U5CW02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

1407499:HHUB RS07650
gene id: 1407499:HHUB_RS07650
uniprot id: A0A0U5H3I2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

1407499:HHUB RS10060
gene id: 1407499:HHUB_RS10060
uniprot id: A0A0U5HW14
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS08325
gene id: 1407499:HHUB_RS08325
uniprot id: A0A0U5H1D7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

1407499:HHUB RS11080
gene id: 1407499:HHUB_RS11080
uniprot id: A0A0U5D0E6
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS02955
gene id: 1407499:HHUB_RS02955
uniprot id: A0A0U5GZW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1407499:HHUB RS07130
gene id: 1407499:HHUB_RS07130
uniprot id: A0A0U5CYI6
names: Function
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
messages: Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC), the main low-molecular-weight thiol compound instead of glutathione in halophilic archaea.

1407499:HHUB RS00755
gene id: 1407499:HHUB_RS00755
uniprot id: A0A0U5H0T4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS11375
gene id: 1407499:HHUB_RS11375
uniprot id: A0A0U5HWT8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS12655
gene id: 1407499:HHUB_RS12655
uniprot id: A0A0U5H644
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

1407499:HHUB RS11360
gene id: 1407499:HHUB_RS11360
uniprot id: A0A0U5H360
names: Similarity
messages: Belongs to the UPF0215 family.

1407499:HHUB RS05085
gene id: 1407499:HHUB_RS05085
uniprot id: A0A0U5H3B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1407499:HHUB RS04190
gene id: 1407499:HHUB_RS04190
uniprot id: A0A0U5GZ09
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

1407499:HHUB RS00225
gene id: 1407499:HHUB_RS00225
uniprot id: A0A0U5CV14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NosZ family.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.
messages: Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide.
messages: Periplasm

1407499:HHUB RS05165
gene id: 1407499:HHUB_RS05165
uniprot id: A0A0U5H5P4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1407499:HHUB RS04945
gene id: 1407499:HHUB_RS04945
uniprot id: A0A0U5H264
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

1407499:HHUB RS01705
gene id: 1407499:HHUB_RS01705
uniprot id: A0A0U5GZK6
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

1407499:HHUB RS09830
gene id: 1407499:HHUB_RS09830
uniprot id: A0A0U5AGK7
names: Similarity
messages: Belongs to the acetolactate synthase small subunit family.

1407499:HHUB RS06600
gene id: 1407499:HHUB_RS06600
uniprot id: A0A0U5CY09
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

1407499:HHUB RS06215
gene id: 1407499:HHUB_RS06215
uniprot id: A0A0U5H3Y4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1407499:HHUB RS12250
gene id: 1407499:HHUB_RS12250
uniprot id: A0A0U5H8P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

1407499:HHUB RS00120
gene id: 1407499:HHUB_RS00120
uniprot id: A0A0U5CV04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

1407499:HHUB RS09430
gene id: 1407499:HHUB_RS09430
uniprot id: A0A0U5H458
names: Similarity
messages: Belongs to the TrpF family.

1407499:HHUB RS14685
gene id: 1407499:HHUB_RS14685
uniprot id: A0A0U5H834
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1407499:HHUB RS08050
gene id: 1407499:HHUB_RS08050
uniprot id: A0A0U5H3R6
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS14025
gene id: 1407499:HHUB_RS14025
uniprot id: A0A0U5H8I3
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS12585
gene id: 1407499:HHUB_RS12585
uniprot id: A0A0U5HXG3
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

1407499:HHUB RS01660
gene id: 1407499:HHUB_RS01660
uniprot id: A0A0U5GYQ8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1407499:HHUB RS11210
gene id: 1407499:HHUB_RS11210
uniprot id: A0A0U5H581
names: Similarity
messages: Belongs to the HAM1 NTPase family.

1407499:HHUB RS04835
gene id: 1407499:HHUB_RS04835
uniprot id: A0A0U5H0Y2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS08510
gene id: 1407499:HHUB_RS08510
uniprot id: A0A0U5HV58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

1407499:HHUB RS10340
gene id: 1407499:HHUB_RS10340
uniprot id: A0A0U5H2F2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

1407499:HHUB RS01590
gene id: 1407499:HHUB_RS01590
uniprot id: A0A0U5H270
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

1407499:HHUB RS07185
gene id: 1407499:HHUB_RS07185
uniprot id: A0A0U5H397
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1407499:HHUB RS13825
gene id: 1407499:HHUB_RS13825
uniprot id: A0A0U5AJK5
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1407499:HHUB RS11165
gene id: 1407499:HHUB_RS11165
uniprot id: A0A0U5H477
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1407499:HHUB RS11410
gene id: 1407499:HHUB_RS11410
uniprot id: A0A0U5D0M8
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS09740
gene id: 1407499:HHUB_RS09740
uniprot id: A0A0U5H4C2
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS14030
gene id: 1407499:HHUB_RS14030
uniprot id: A0A0U5D274
names: Similarity
messages: Belongs to the ComB family.

1407499:HHUB RS01515
gene id: 1407499:HHUB_RS01515
uniprot id: A0A0U5GXL6
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

1407499:HHUB RS10125
gene id: 1407499:HHUB_RS10125
uniprot id: A0A0U5H699
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

1407499:HHUB RS05350
gene id: 1407499:HHUB_RS05350
uniprot id: A0A0U5ADQ9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.

1407499:HHUB RS04010
gene id: 1407499:HHUB_RS04010
uniprot id: A0A0U5H035
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

1407499:HHUB RS15695
gene id: 1407499:HHUB_RS15695
uniprot id: A0A0U5HZA9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS10510
gene id: 1407499:HHUB_RS10510
uniprot id: A0A0U5AHI0
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS01930
gene id: 1407499:HHUB_RS01930
uniprot id: A0A0U5H1D5
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

1407499:HHUB RS10560
gene id: 1407499:HHUB_RS10560
uniprot id: A0A0U5H907
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

1407499:HHUB RS12470
gene id: 1407499:HHUB_RS12470
uniprot id: A0A0U5D138
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

1407499:HHUB RS00355
gene id: 1407499:HHUB_RS00355
uniprot id: A0A0U5HQK8
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS04065
gene id: 1407499:HHUB_RS04065
uniprot id: A0A0U5H1F6
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1407499:HHUB RS08725
gene id: 1407499:HHUB_RS08725
uniprot id: A0A0U5H4E9
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS06230
gene id: 1407499:HHUB_RS06230
uniprot id: A0A0U5H300
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1407499:HHUB RS09245
gene id: 1407499:HHUB_RS09245
uniprot id: A0A0U5CZG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1407499:HHUB RS14395
gene id: 1407499:HHUB_RS14395
uniprot id: A0A0U5H4Q3
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS00535
gene id: 1407499:HHUB_RS00535
uniprot id: A0A0U5CV66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the oxidation of methyl-H(4)MPT to methylene-H(4)MPT.
messages: Cytoplasm

1407499:HHUB RS08435
gene id: 1407499:HHUB_RS08435
uniprot id: A0A0U5AFM2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1407499:HHUB RS05260
gene id: 1407499:HHUB_RS05260
uniprot id: A0A0U5H1P4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS14860
gene id: 1407499:HHUB_RS14860
uniprot id: A0A0U5D2R2
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1407499:HHUB RS13465
gene id: 1407499:HHUB_RS13465
uniprot id: A0A0U5H858
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1407499:HHUB RS08470
gene id: 1407499:HHUB_RS08470
uniprot id: A0A0U5CZ30
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1407499:HHUB RS02105
gene id: 1407499:HHUB_RS02105
uniprot id: A0A0U5AB81
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

1407499:HHUB RS09960
gene id: 1407499:HHUB_RS09960
uniprot id: A0A0U5H2A1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1407499:HHUB RS05465
gene id: 1407499:HHUB_RS05465
uniprot id: A0A0U5CXR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

1407499:HHUB RS14565
gene id: 1407499:HHUB_RS14565
uniprot id: A0A0U5H7M5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS04935
gene id: 1407499:HHUB_RS04935
uniprot id: A0A0U5H470
names: Similarity
messages: Belongs to the UPF0212 family.

1407499:HHUB RS02965
gene id: 1407499:HHUB_RS02965
uniprot id: A0A0U5H252
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

1407499:HHUB RS12945
gene id: 1407499:HHUB_RS12945
uniprot id: A0A0U5H432
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

1407499:HHUB RS12290
gene id: 1407499:HHUB_RS12290
uniprot id: A0A0U5H5D2
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS03685
gene id: 1407499:HHUB_RS03685
uniprot id: A0A0U5CWT8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

1407499:HHUB RS12320
gene id: 1407499:HHUB_RS12320
uniprot id: A0A0U5H8R0
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

1407499:HHUB RS00780
gene id: 1407499:HHUB_RS00780
uniprot id: A0A0U5H318
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS09185
gene id: 1407499:HHUB_RS09185
uniprot id: A0A0U5H5L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
messages: Cell membrane
messages: Forms a complex with DabB.
messages: Part of an energy-coupled inorganic carbon pump.

1407499:HHUB RS00655
gene id: 1407499:HHUB_RS00655
uniprot id: A0A0U5GX56
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS08555
gene id: 1407499:HHUB_RS08555
uniprot id: A0A0U5H588
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

1407499:HHUB RS07555
gene id: 1407499:HHUB_RS07555
uniprot id: A0A0U5H307
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS04390
gene id: 1407499:HHUB_RS04390
uniprot id: A0A0U5H2Y6
names: Similarity
messages: Belongs to the PEPCase type 1 family.

1407499:HHUB RS06090
gene id: 1407499:HHUB_RS06090
uniprot id: A0A0U5AE74
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS05865
gene id: 1407499:HHUB_RS05865
uniprot id: A0A0U5AE19
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS03410
gene id: 1407499:HHUB_RS03410
uniprot id: A0A0U5GYT0
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS00125
gene id: 1407499:HHUB_RS00125
uniprot id: A0A0U5GXW9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1407499:HHUB RS00335
gene id: 1407499:HHUB_RS00335
uniprot id: A0A0U5GZH2
names: Similarity
messages: Belongs to the carbamate kinase family.

1407499:HHUB RS04405
gene id: 1407499:HHUB_RS04405
uniprot id: A0A0U5H1V2
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

1407499:HHUB RS07495
gene id: 1407499:HHUB_RS07495
uniprot id: A0A0U5H2F6
names: Subcellular Location Annotation
messages: Cytoplasm

1407499:HHUB RS02140
gene id: 1407499:HHUB_RS02140
uniprot id: A0A0U5CVR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

1407499:HHUB RS06320
gene id: 1407499:HHUB_RS06320
uniprot id: A0A0U5H058
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1407499:HHUB RS07125
gene id: 1407499:HHUB_RS07125
uniprot id: A0A0U5H1U5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

1407499:HHUB RS05490
gene id: 1407499:HHUB_RS05490
uniprot id: A0A0U5GZQ7
names: Function
names: Subunit
messages: Interacts with chemotaxis (Che) proteins as well as flagella accessory (Fla) proteins.
messages: Involved in taxis signal transduction.

1407499:HHUB RS01950
gene id: 1407499:HHUB_RS01950
uniprot id: A0A0U5GXT8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1407499:HHUB RS09060
gene id: 1407499:HHUB_RS09060
uniprot id: A0A0U5HVH0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1407499:HHUB RS06260
gene id: 1407499:HHUB_RS06260
uniprot id: A0A0U5H1T4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

1407499:HHUB RS10770
gene id: 1407499:HHUB_RS10770
uniprot id: A0A0U5D009
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

1407499:HHUB RS08585
gene id: 1407499:HHUB_RS08585
uniprot id: A0A0U5HV71
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

1407499:HHUB RS03140
gene id: 1407499:HHUB_RS03140
uniprot id: A0A0U5CWE6
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS12085
gene id: 1407499:HHUB_RS12085
uniprot id: A0A0U5H4Q8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS02185
gene id: 1407499:HHUB_RS02185
uniprot id: A0A0U5ABA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

1407499:HHUB RS12430
gene id: 1407499:HHUB_RS12430
uniprot id: A0A0U5HXD1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1407499:HHUB RS05945
gene id: 1407499:HHUB_RS05945
uniprot id: A0A0U5H1L4
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

1407499:HHUB RS00340
gene id: 1407499:HHUB_RS00340
uniprot id: A0A0U5GWY3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS05040
gene id: 1407499:HHUB_RS05040
uniprot id: A0A0U5HT79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1407499:HHUB RS03595
gene id: 1407499:HHUB_RS03595
uniprot id: A0A0U5H2D5
names: Subcellular Location Annotation
messages: Cytoplasm

1407499:HHUB RS04760
gene id: 1407499:HHUB_RS04760
uniprot id: A0A0U5H0X0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1407499:HHUB RS06495
gene id: 1407499:HHUB_RS06495
uniprot id: A0A0U5HU08
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1407499:HHUB RS09480
gene id: 1407499:HHUB_RS09480
uniprot id: A0A0U5H6V3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.
messages: Membrane

1407499:HHUB RS10350
gene id: 1407499:HHUB_RS10350
uniprot id: A0A0U5HW81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1407499:HHUB RS11525
gene id: 1407499:HHUB_RS11525
uniprot id: A0A0U5H5F4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS06385
gene id: 1407499:HHUB_RS06385
uniprot id: A0A0U5H507
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1407499:HHUB RS01900
gene id: 1407499:HHUB_RS01900
uniprot id: A0A0U5H089
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS14110
gene id: 1407499:HHUB_RS14110
uniprot id: A0A0U5D1V6
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS02110
gene id: 1407499:HHUB_RS02110
uniprot id: A0A0U5GZF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

1407499:HHUB RS14445
gene id: 1407499:HHUB_RS14445
uniprot id: A0A0U5H666
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS13845
gene id: 1407499:HHUB_RS13845
uniprot id: A0A0U5D243
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

1407499:HHUB RS14105
gene id: 1407499:HHUB_RS14105
uniprot id: A0A0U5H5Y8
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

1407499:HHUB RS10200
gene id: 1407499:HHUB_RS10200
uniprot id: A0A0U5H442
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS06065
gene id: 1407499:HHUB_RS06065
uniprot id: A0A0U5H2W2
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.
messages: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).

1407499:HHUB RS11035
gene id: 1407499:HHUB_RS11035
uniprot id: A0A0U5H5V8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

1407499:HHUB RS05160
gene id: 1407499:HHUB_RS05160
uniprot id: A0A0U5H4B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

1407499:HHUB RS01465
gene id: 1407499:HHUB_RS01465
uniprot id: A0A0U5H178
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

1407499:HHUB RS15140
gene id: 1407499:HHUB_RS15140
uniprot id: A0A0U5D293
names: Subcellular Location Annotation
messages: Cytoplasm

1407499:HHUB RS10450
gene id: 1407499:HHUB_RS10450
uniprot id: A0A0U5H6G5
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

1407499:HHUB RS02560
gene id: 1407499:HHUB_RS02560
uniprot id: A0A0U5HRW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ModE family.
messages: Membrane

1407499:HHUB RS12460
gene id: 1407499:HHUB_RS12460
uniprot id: A0A0U5D0Z4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

1407499:HHUB RS02935
gene id: 1407499:HHUB_RS02935
uniprot id: A0A0U5GYJ0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS06370
gene id: 1407499:HHUB_RS06370
uniprot id: A0A0U5H1D0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

1407499:HHUB RS04860
gene id: 1407499:HHUB_RS04860
uniprot id: A0A0U5H0J1
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

1407499:HHUB RS12215
gene id: 1407499:HHUB_RS12215
uniprot id: A0A0U5H7H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

1407499:HHUB RS10540
gene id: 1407499:HHUB_RS10540
uniprot id: A0A0U5H3U3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

1407499:HHUB RS04380
gene id: 1407499:HHUB_RS04380
uniprot id: A0A0U5H0A3
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS08115
gene id: 1407499:HHUB_RS08115
uniprot id: A0A0U5H2U8
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS09995
gene id: 1407499:HHUB_RS09995
uniprot id: A0A0U5H4Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

1407499:HHUB RS12955
gene id: 1407499:HHUB_RS12955
uniprot id: A0A0U5H6B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

1407499:HHUB RS02485
gene id: 1407499:HHUB_RS02485
uniprot id: A0A0U5HRU9
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

1407499:HHUB RS00020
gene id: 1407499:HHUB_RS00020
uniprot id: A0A0U5A9S1
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1407499:HHUB RS07095
gene id: 1407499:HHUB_RS07095
uniprot id: A0A0U5AES7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS03340
gene id: 1407499:HHUB_RS03340
uniprot id: A0A0U5H0K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1407499:HHUB RS12495
gene id: 1407499:HHUB_RS12495
uniprot id: A0A0U5H3T2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

1407499:HHUB RS01625
gene id: 1407499:HHUB_RS01625
uniprot id: A0A0U5HRC2
names: Similarity
messages: Belongs to the HypE family.

1407499:HHUB RS09925
gene id: 1407499:HHUB_RS09925
uniprot id: A0A0U5CZU7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS02270
gene id: 1407499:HHUB_RS02270
uniprot id: A0A0U5H0F8
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase involved in purine salvage.

1407499:HHUB RS10375
gene id: 1407499:HHUB_RS10375
uniprot id: A0A0U5D025
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1407499:HHUB RS10410
gene id: 1407499:HHUB_RS10410
uniprot id: A0A0U5H5H3
names: Similarity
messages: Belongs to the UPF0045 family.

1407499:HHUB RS01895
gene id: 1407499:HHUB_RS01895
uniprot id: A0A0U5GZA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1407499:HHUB RS05215
gene id: 1407499:HHUB_RS05215
uniprot id: A0A0U5CXF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Homodimer.

1407499:HHUB RS05500
gene id: 1407499:HHUB_RS05500
uniprot id: A0A0U5H1U2
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

1407499:HHUB RS02165
gene id: 1407499:HHUB_RS02165
uniprot id: A0A0U5GXY1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS13835
gene id: 1407499:HHUB_RS13835
uniprot id: A0A0U5H774
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

1407499:HHUB RS14035
gene id: 1407499:HHUB_RS14035
uniprot id: A0A0U5D1Q1
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

1407499:HHUB RS09855
gene id: 1407499:HHUB_RS09855
uniprot id: A0A0U5H3D5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

1407499:HHUB RS03175
gene id: 1407499:HHUB_RS03175
uniprot id: A0A0U5H0H0
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

1407499:HHUB RS10795
gene id: 1407499:HHUB_RS10795
uniprot id: A0A0U5H954
names: Similarity
messages: Belongs to the thymidylate kinase family.

1407499:HHUB RS04270
gene id: 1407499:HHUB_RS04270
uniprot id: A0A0U5H156
names: Similarity
messages: Belongs to the AOR/FOR family.

1407499:HHUB RS03630
gene id: 1407499:HHUB_RS03630
uniprot id: A0A0U5H4V2
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS01540
gene id: 1407499:HHUB_RS01540
uniprot id: A0A0U5HRA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1407499:HHUB RS15385
gene id: 1407499:HHUB_RS15385
uniprot id: A0A0U5HAN8
names: Similarity
messages: Belongs to the UPF0175 family.

1407499:HHUB RS01115
gene id: 1407499:HHUB_RS01115
uniprot id: A0A0U5HR20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1407499:HHUB RS09055
gene id: 1407499:HHUB_RS09055
uniprot id: A0A0U5H3X5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

1407499:HHUB RS14020
gene id: 1407499:HHUB_RS14020
uniprot id: A0A0U5H7A9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1407499:HHUB RS03955
gene id: 1407499:HHUB_RS03955
uniprot id: A0A0U5H1L2
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS15295
gene id: 1407499:HHUB_RS15295
uniprot id: A0A0U5D2B8
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

1407499:HHUB RS07300
gene id: 1407499:HHUB_RS07300
uniprot id: A0A0U5H720
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

1407499:HHUB RS06305
gene id: 1407499:HHUB_RS06305
uniprot id: A0A0U5H4Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1407499:HHUB RS06880
gene id: 1407499:HHUB_RS06880
uniprot id: A0A0U5CY63
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1407499:HHUB RS05835
gene id: 1407499:HHUB_RS05835
uniprot id: A0A0U5H657
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

1407499:HHUB RS15840
gene id: 1407499:HHUB_RS15840
uniprot id: A0A0U5H882
names: Similarity
messages: Belongs to the MCM family.

1407499:HHUB RS12775
gene id: 1407499:HHUB_RS12775
uniprot id: A0A0U5H548
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

1407499:HHUB RS06700
gene id: 1407499:HHUB_RS06700
uniprot id: A0A0U5H0G1
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS15350
gene id: 1407499:HHUB_RS15350
uniprot id: A0A0U5H9G0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1407499:HHUB RS09945
gene id: 1407499:HHUB_RS09945
uniprot id: A0A0U5H5Y6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

1407499:HHUB RS06835
gene id: 1407499:HHUB_RS06835
uniprot id: A0A0U5H6R4
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS00395
gene id: 1407499:HHUB_RS00395
uniprot id: A0A0U5CUY2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

1407499:HHUB RS07480
gene id: 1407499:HHUB_RS07480
uniprot id: A0A0U5H2Z0
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

1407499:HHUB RS06980
gene id: 1407499:HHUB_RS06980
uniprot id: A0A0U5H6V1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1407499:HHUB RS07255
gene id: 1407499:HHUB_RS07255
uniprot id: A0A0U5H2A2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1407499:HHUB RS03605
gene id: 1407499:HHUB_RS03605
uniprot id: A0A0U5CWS4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS11255
gene id: 1407499:HHUB_RS11255
uniprot id: A0A0U5D0K6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1407499:HHUB RS03050
gene id: 1407499:HHUB_RS03050
uniprot id: A0A0U5CW49
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS10460
gene id: 1407499:HHUB_RS10460
uniprot id: A0A0U5H3S3
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

1407499:HHUB RS01475
gene id: 1407499:HHUB_RS01475
uniprot id: A0A0U5CVM6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1407499:HHUB RS03650
gene id: 1407499:HHUB_RS03650
uniprot id: A0A0U5H0T1
names: Function
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: May catalyze a purine salvage reaction, the substrate is unknown.

1407499:HHUB RS12625
gene id: 1407499:HHUB_RS12625
uniprot id: A0A0U5H7L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

1407499:HHUB RS01545
gene id: 1407499:HHUB_RS01545
uniprot id: A0A0U5AAT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1407499:HHUB RS10260
gene id: 1407499:HHUB_RS10260
uniprot id: A0A0U5H2D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

1407499:HHUB RS08385
gene id: 1407499:HHUB_RS08385
uniprot id: A0A0U5CZ19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1407499:HHUB RS01620
gene id: 1407499:HHUB_RS01620
uniprot id: A0A0U5GZI8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

1407499:HHUB RS05990
gene id: 1407499:HHUB_RS05990
uniprot id: A0A0U5H2V2
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS03045
gene id: 1407499:HHUB_RS03045
uniprot id: A0A0U5H258
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS10385
gene id: 1407499:HHUB_RS10385
uniprot id: A0A0U5H3Q5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

1407499:HHUB RS09140
gene id: 1407499:HHUB_RS09140
uniprot id: A0A0U5HVI4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

1407499:HHUB RS11220
gene id: 1407499:HHUB_RS11220
uniprot id: A0A0U5AI20
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

1407499:HHUB RS06380
gene id: 1407499:HHUB_RS06380
uniprot id: A0A0U5H415
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS04180
gene id: 1407499:HHUB_RS04180
uniprot id: A0A0U5H556
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

1407499:HHUB RS02545
gene id: 1407499:HHUB_RS02545
uniprot id: A0A0U5GY64
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1407499:HHUB RS14905
gene id: 1407499:HHUB_RS14905
uniprot id: A0A0U5H7L3
names: Function
messages: Part of a potassium transport system.

1407499:HHUB RS07825
gene id: 1407499:HHUB_RS07825
uniprot id: A0A0U5H273
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

1407499:HHUB RS11335
gene id: 1407499:HHUB_RS11335
uniprot id: A0A0U5D0L8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS07620
gene id: 1407499:HHUB_RS07620
uniprot id: A0A0U5H3S2
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS09150
gene id: 1407499:HHUB_RS09150
uniprot id: A0A0U5H3G0
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

1407499:HHUB RS13830
gene id: 1407499:HHUB_RS13830
uniprot id: A0A0U5H683
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

1407499:HHUB RS10000
gene id: 1407499:HHUB_RS10000
uniprot id: A0A0U5H664
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

1407499:HHUB RS01165
gene id: 1407499:HHUB_RS01165
uniprot id: A0A0U5H203
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1407499:HHUB RS06100
gene id: 1407499:HHUB_RS06100
uniprot id: A0A0U5H2M4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

1407499:HHUB RS06105
gene id: 1407499:HHUB_RS06105
uniprot id: A0A0U5H3T5
names: Similarity
messages: Belongs to the anthranilate synthase component I family.
messages: Belongs to the isochorismate synthase family.

1407499:HHUB RS05460
gene id: 1407499:HHUB_RS05460
uniprot id: A0A0U5H0U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

1407499:HHUB RS05450
gene id: 1407499:HHUB_RS05450
uniprot id: A0A0U5CXI8
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1407499:HHUB RS09550
gene id: 1407499:HHUB_RS09550
uniprot id: A0A0U5H5R7
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

1407499:HHUB RS13170
gene id: 1407499:HHUB_RS13170
uniprot id: A0A0U5HAI5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS01865
gene id: 1407499:HHUB_RS01865
uniprot id: A0A0U5H093
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

1407499:HHUB RS08560
gene id: 1407499:HHUB_RS08560
uniprot id: A0A0U5H688
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

1407499:HHUB RS02220
gene id: 1407499:HHUB_RS02220
uniprot id: A0A0U5H1K5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS03390
gene id: 1407499:HHUB_RS03390
uniprot id: A0A0U5H3B2
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS04890
gene id: 1407499:HHUB_RS04890
uniprot id: A0A0U5GZI2
names: Similarity
messages: Belongs to the arginase family.

1407499:HHUB RS07720
gene id: 1407499:HHUB_RS07720
uniprot id: A0A0U5H2K7
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS08895
gene id: 1407499:HHUB_RS08895
uniprot id: A0A0U5H3U0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1407499:HHUB RS08545
gene id: 1407499:HHUB_RS08545
uniprot id: A0A0U5H2M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1407499:HHUB RS02370
gene id: 1407499:HHUB_RS02370
uniprot id: A0A0U5CVW3
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

1407499:HHUB RS06785
gene id: 1407499:HHUB_RS06785
uniprot id: A0A0U5AEL2
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS08465
gene id: 1407499:HHUB_RS08465
uniprot id: A0A0U5H2L2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

1407499:HHUB RS11015
gene id: 1407499:HHUB_RS11015
uniprot id: A0A0U5D0F9
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

1407499:HHUB RS12540
gene id: 1407499:HHUB_RS12540
uniprot id: A0A0U5D109
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

1407499:HHUB RS11275
gene id: 1407499:HHUB_RS11275
uniprot id: A0A0U5H624
names: Similarity
messages: Belongs to the AAA ATPase family.

1407499:HHUB RS08995
gene id: 1407499:HHUB_RS08995
uniprot id: A0A0U5H5I2
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS05045
gene id: 1407499:HHUB_RS05045
uniprot id: A0A0U5ADJ6
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS03350
gene id: 1407499:HHUB_RS03350
uniprot id: A0A0U5AC36
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1407499:HHUB RS01345
gene id: 1407499:HHUB_RS01345
uniprot id: A0A0U5GXI3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1407499:HHUB RS09775
gene id: 1407499:HHUB_RS09775
uniprot id: A0A0U5CZJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1407499:HHUB RS04530
gene id: 1407499:HHUB_RS04530
uniprot id: A0A0U5CWZ5
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

1407499:HHUB RS08065
gene id: 1407499:HHUB_RS08065
uniprot id: A0A0U5H2C4
names: Subunit
messages: Homotrimer.

1407499:HHUB RS09190
gene id: 1407499:HHUB_RS09190
uniprot id: A0A0U5H6N8
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS11450
gene id: 1407499:HHUB_RS11450
uniprot id: A0A0U5H5D4
names: Similarity
messages: Belongs to the RutC family.

1407499:HHUB RS10950
gene id: 1407499:HHUB_RS10950
uniprot id: A0A0U5H993
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

1407499:HHUB RS08390
gene id: 1407499:HHUB_RS08390
uniprot id: A0A0U5H551
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1407499:HHUB RS05485
gene id: 1407499:HHUB_RS05485
uniprot id: A0A0U5H2J2
names: Function
names: Subunit
messages: Interacts with chemotaxis (Che) proteins as well as flagella accessory (Fla) proteins.
messages: Involved in taxis signal transduction.

1407499:HHUB RS13045
gene id: 1407499:HHUB_RS13045
uniprot id: A0A0U5H6R5
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS01085
gene id: 1407499:HHUB_RS01085
uniprot id: A0A0U5H392
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS09795
gene id: 1407499:HHUB_RS09795
uniprot id: A0A0U5H722
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS09450
gene id: 1407499:HHUB_RS09450
uniprot id: A0A0U5H5U0
names: Subcellular Location Annotation
messages: Cytoplasm

1407499:HHUB RS08685
gene id: 1407499:HHUB_RS08685
uniprot id: A0A0U5H5B8
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

1407499:HHUB RS06400
gene id: 1407499:HHUB_RS06400
uniprot id: A0A0U5H088
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

1407499:HHUB RS14155
gene id: 1407499:HHUB_RS14155
uniprot id: A0A0U5HYD1
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS12075
gene id: 1407499:HHUB_RS12075
uniprot id: A0A0U5D119
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1407499:HHUB RS03745
gene id: 1407499:HHUB_RS03745
uniprot id: A0A0U5H0C4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

1407499:HHUB RS00145
gene id: 1407499:HHUB_RS00145
uniprot id: A0A0U5H2N4
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

1407499:HHUB RS00520
gene id: 1407499:HHUB_RS00520
uniprot id: A0A0U5AA29
names: Similarity
messages: Belongs to the SUI1 family.

1407499:HHUB RS11580
gene id: 1407499:HHUB_RS11580
uniprot id: A0A0U5H8A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

1407499:HHUB RS12980
gene id: 1407499:HHUB_RS12980
uniprot id: A0A0U5H7X2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

1407499:HHUB RS10555
gene id: 1407499:HHUB_RS10555
uniprot id: A0A0U5H7K8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

1407499:HHUB RS10765
gene id: 1407499:HHUB_RS10765
uniprot id: A0A0U5D095
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

1407499:HHUB RS11045
gene id: 1407499:HHUB_RS11045
uniprot id: A0A0U5H2U3
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS01955
gene id: 1407499:HHUB_RS01955
uniprot id: A0A0U5GY05
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

1407499:HHUB RS15240
gene id: 1407499:HHUB_RS15240
uniprot id: A0A0U5HBU8
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1407499:HHUB RS05140
gene id: 1407499:HHUB_RS05140
uniprot id: A0A0U5H389
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS14590
gene id: 1407499:HHUB_RS14590
uniprot id: A0A0U5H8V5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS13805
gene id: 1407499:HHUB_RS13805
uniprot id: A0A0U5H5S1
names: Similarity
messages: Belongs to the UPF0175 family.

1407499:HHUB RS00585
gene id: 1407499:HHUB_RS00585
uniprot id: A0A0U5GYY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

1407499:HHUB RS00425
gene id: 1407499:HHUB_RS00425
uniprot id: A0A0U5GYV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH.
messages: Homotetramer.

1407499:HHUB RS05805
gene id: 1407499:HHUB_RS05805
uniprot id: A0A0U5CXP4
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

1407499:HHUB RS09725
gene id: 1407499:HHUB_RS09725
uniprot id: A0A0U5H513
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS09700
gene id: 1407499:HHUB_RS09700
uniprot id: A0A0U5H3B0
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

1407499:HHUB RS08910
gene id: 1407499:HHUB_RS08910
uniprot id: A0A0U5H3A2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

1407499:HHUB RS07775
gene id: 1407499:HHUB_RS07775
uniprot id: A0A0U5H128
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1407499:HHUB RS01150
gene id: 1407499:HHUB_RS01150
uniprot id: A0A0U5GYH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

1407499:HHUB RS15105
gene id: 1407499:HHUB_RS15105
uniprot id: A0A0U5H7R6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS09305
gene id: 1407499:HHUB_RS09305
uniprot id: A0A0U5H5P8
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS00055
gene id: 1407499:HHUB_RS00055
uniprot id: A0A0U5H096
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS10010
gene id: 1407499:HHUB_RS10010
uniprot id: A0A0U5CZN4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1407499:HHUB RS09000
gene id: 1407499:HHUB_RS09000
uniprot id: A0A0U5CZB5
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS04660
gene id: 1407499:HHUB_RS04660
uniprot id: A0A0U5H1C4
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS07730
gene id: 1407499:HHUB_RS07730
uniprot id: A0A0U5H4S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Nucleus

1407499:HHUB RS12720
gene id: 1407499:HHUB_RS12720
uniprot id: A0A0U5H6V9
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS08480
gene id: 1407499:HHUB_RS08480
uniprot id: A0A0U5H670
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

1407499:HHUB RS03170
gene id: 1407499:HHUB_RS03170
uniprot id: A0A0U5GYM9
names: Similarity
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

1407499:HHUB RS11405
gene id: 1407499:HHUB_RS11405
uniprot id: A0A0U5H4C5
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

1407499:HHUB RS02600
gene id: 1407499:HHUB_RS02600
uniprot id: A0A0U5CW08
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

1407499:HHUB RS11865
gene id: 1407499:HHUB_RS11865
uniprot id: A0A0U5H555
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

1407499:HHUB RS07530
gene id: 1407499:HHUB_RS07530
uniprot id: A0A0U5H5Q5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

1407499:HHUB RS03815
gene id: 1407499:HHUB_RS03815
uniprot id: A0A0U5HSJ9
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

1407499:HHUB RS00470
gene id: 1407499:HHUB_RS00470
uniprot id: A0A0U5GY37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

1407499:HHUB RS08730
gene id: 1407499:HHUB_RS08730
uniprot id: A0A0U5H1L8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

1407499:HHUB RS01975
gene id: 1407499:HHUB_RS01975
uniprot id: A0A0U5GZC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

1407499:HHUB RS11225
gene id: 1407499:HHUB_RS11225
uniprot id: A0A0U5H4S7
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit.

1407499:HHUB RS13305
gene id: 1407499:HHUB_RS13305
uniprot id: A0A0U5D1L6
names: Similarity
messages: Belongs to the glycosyl hydrolase 51 family.

1407499:HHUB RS10205
gene id: 1407499:HHUB_RS10205
uniprot id: A0A0U5H528
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1407499:HHUB RS01125
gene id: 1407499:HHUB_RS01125
uniprot id: A0A0U5GYX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1407499:HHUB RS07100
gene id: 1407499:HHUB_RS07100
uniprot id: A0A0U5H290
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

1407499:HHUB RS10290
gene id: 1407499:HHUB_RS10290
uniprot id: A0A0U5H6D4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1407499:HHUB RS12555
gene id: 1407499:HHUB_RS12555
uniprot id: A0A0U5H7J3
names: Similarity
messages: Belongs to the UPF0201 family.

1407499:HHUB RS05210
gene id: 1407499:HHUB_RS05210
uniprot id: A0A0U5CXF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

1407499:HHUB RS14895
gene id: 1407499:HHUB_RS14895
uniprot id: A0A0U5H599
names: Function
messages: Part of a potassium transport system.

1407499:HHUB RS02295
gene id: 1407499:HHUB_RS02295
uniprot id: A0A0U5CVU8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

1407499:HHUB RS15455
gene id: 1407499:HHUB_RS15455
uniprot id: A0A0U5HAQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1407499:HHUB RS00605
gene id: 1407499:HHUB_RS00605
uniprot id: A0A0U5GZI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

1407499:HHUB RS03495
gene id: 1407499:HHUB_RS03495
uniprot id: A0A0U5H0P9
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

1407499:HHUB RS12620
gene id: 1407499:HHUB_RS12620
uniprot id: A0A0U5D164
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS06840
gene id: 1407499:HHUB_RS06840
uniprot id: A0A0U5H3B7
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS12680
gene id: 1407499:HHUB_RS12680
uniprot id: A0A0U5H7Q9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

1407499:HHUB RS10370
gene id: 1407499:HHUB_RS10370
uniprot id: A0A0U5H6F1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1407499:HHUB RS10415
gene id: 1407499:HHUB_RS10415
uniprot id: A0A0U5H2H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
messages: Cytoplasm

1407499:HHUB RS07885
gene id: 1407499:HHUB_RS07885
uniprot id: A0A0U5H3N4
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS03405
gene id: 1407499:HHUB_RS03405
uniprot id: A0A0U5GYM4
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS08370
gene id: 1407499:HHUB_RS08370
uniprot id: A0A0U5CYZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1407499:HHUB RS12995
gene id: 1407499:HHUB_RS12995
uniprot id: A0A0U5H594
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

1407499:HHUB RS12360
gene id: 1407499:HHUB_RS12360
uniprot id: A0A0U5H5F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

1407499:HHUB RS01225
gene id: 1407499:HHUB_RS01225
uniprot id: A0A0U5CV51
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS09815
gene id: 1407499:HHUB_RS09815
uniprot id: A0A0U5H265
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

1407499:HHUB RS13150
gene id: 1407499:HHUB_RS13150
uniprot id: A0A0U5H5C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1407499:HHUB RS02575
gene id: 1407499:HHUB_RS02575
uniprot id: A0A0U5H0L7
names: Caution
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS10685
gene id: 1407499:HHUB_RS10685
uniprot id: A0A0U5H3X0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

1407499:HHUB RS02130
gene id: 1407499:HHUB_RS02130
uniprot id: A0A0U5CW29
names: Similarity
messages: Belongs to the TrpC family.

1407499:HHUB RS10945
gene id: 1407499:HHUB_RS10945
uniprot id: A0A0U5H7V8
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS10360
gene id: 1407499:HHUB_RS10360
uniprot id: A0A0U5H481
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

1407499:HHUB RS07705
gene id: 1407499:HHUB_RS07705
uniprot id: A0A0U5H342
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

1407499:HHUB RS14505
gene id: 1407499:HHUB_RS14505
uniprot id: A0A0U5H8T4
names: Subcellular Location Annotation
messages: Cytoplasm

1407499:HHUB RS10425
gene id: 1407499:HHUB_RS10425
uniprot id: A0A0U5H4Q7
names: Subcellular Location Annotation
messages: Cell membrane

1407499:HHUB RS04100
gene id: 1407499:HHUB_RS04100
uniprot id: A0A0U5H3S6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1407499:HHUB RS08430
gene id: 1407499:HHUB_RS08430
uniprot id: A0A0U5HV40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1407499:HHUB RS01410
gene id: 1407499:HHUB_RS01410
uniprot id: A0A0U5H3G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1407499:HHUB RS10005
gene id: 1407499:HHUB_RS10005
uniprot id: A0A0U5CZV9
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

1407499:HHUB RS09810
gene id: 1407499:HHUB_RS09810
uniprot id: A0A0U5H285
names: Function
names: Similarity
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

1407499:HHUB RS10345
gene id: 1407499:HHUB_RS10345
uniprot id: A0A0U5H4P1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1407499:HHUB RS10965
gene id: 1407499:HHUB_RS10965
uniprot id: A0A0U5H2S7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

1407499:HHUB RS00575
gene id: 1407499:HHUB_RS00575
uniprot id: A0A0U5GX36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

1407499:HHUB RS01630
gene id: 1407499:HHUB_RS01630
uniprot id: A0A0U5AAV6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

1407499:HHUB RS01550
gene id: 1407499:HHUB_RS01550
uniprot id: A0A0U5GZ54
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS08595
gene id: 1407499:HHUB_RS08595
uniprot id: A0A0U5H337
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

1407499:HHUB RS02880
gene id: 1407499:HHUB_RS02880
uniprot id: A0A0U5H0S7
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS11530
gene id: 1407499:HHUB_RS11530
uniprot id: A0A0U5HWW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

1407499:HHUB RS10940
gene id: 1407499:HHUB_RS10940
uniprot id: A0A0U5H6J2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

1407499:HHUB RS12490
gene id: 1407499:HHUB_RS12490
uniprot id: A0A0U5H6R0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

1407499:HHUB RS15245
gene id: 1407499:HHUB_RS15245
uniprot id: A0A0U5H8G7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1407499:HHUB RS13010
gene id: 1407499:HHUB_RS13010
uniprot id: A0A0U5HAE9
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

1407499:HHUB RS01445
gene id: 1407499:HHUB_RS01445
uniprot id: A0A0U5HR87
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS15080
gene id: 1407499:HHUB_RS15080
uniprot id: A0A0U5HAH7
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS06530
gene id: 1407499:HHUB_RS06530
uniprot id: A0A0U5H1G1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS09315
gene id: 1407499:HHUB_RS09315
uniprot id: A0A0U5CZD5
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS00590
gene id: 1407499:HHUB_RS00590
uniprot id: A0A0U5HQQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

1407499:HHUB RS02780
gene id: 1407499:HHUB_RS02780
uniprot id: A0A0U5GYF6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS13115
gene id: 1407499:HHUB_RS13115
uniprot id: A0A0U5HXR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1407499:HHUB RS07790
gene id: 1407499:HHUB_RS07790
uniprot id: A0A0U5HUS1
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

1407499:HHUB RS02125
gene id: 1407499:HHUB_RS02125
uniprot id: A0A0U5CVP7
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

1407499:HHUB RS09755
gene id: 1407499:HHUB_RS09755
uniprot id: A0A0U5H3T6
names: Subcellular Location Annotation
messages: Cytoplasm

1407499:HHUB RS00550
gene id: 1407499:HHUB_RS00550
uniprot id: A0A0U5CV08
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1407499:HHUB RS10285
gene id: 1407499:HHUB_RS10285
uniprot id: A0A0U5H544
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1407499:HHUB RS08915
gene id: 1407499:HHUB_RS08915
uniprot id: A0A0U5H4A3
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

1407499:HHUB RS10545
gene id: 1407499:HHUB_RS10545
uniprot id: A0A0U5D062
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

1407499:HHUB RS00130
gene id: 1407499:HHUB_RS00130
uniprot id: A0A0U5CUU4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

1407499:HHUB RS07570
gene id: 1407499:HHUB_RS07570
uniprot id: A0A0U5H2H8
names: Similarity
messages: Belongs to the FUN14 family.

1407499:HHUB RS05030
gene id: 1407499:HHUB_RS05030
uniprot id: A0A0U5GZK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

1407499:HHUB RS13225
gene id: 1407499:HHUB_RS13225
uniprot id: A0A0U5D1K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1407499:HHUB RS08495
gene id: 1407499:HHUB_RS08495
uniprot id: A0A0U5H1G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

1407499:HHUB RS03750
gene id: 1407499:HHUB_RS03750
uniprot id: A0A0U5H1A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

1407499:HHUB RS09825
gene id: 1407499:HHUB_RS09825
uniprot id: A0A0U5HVV3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS10960
gene id: 1407499:HHUB_RS10960
uniprot id: A0A0U5H2U5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

1407499:HHUB RS00645
gene id: 1407499:HHUB_RS00645
uniprot id: A0A0U5H2Y3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

1407499:HHUB RS04680
gene id: 1407499:HHUB_RS04680
uniprot id: A0A0U5H1S0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

1407499:HHUB RS02940
gene id: 1407499:HHUB_RS02940
uniprot id: A0A0U5H0D2
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS12330
gene id: 1407499:HHUB_RS12330
uniprot id: A0A0U5H6M8
names: Similarity
messages: Belongs to the peptidase S9C family.

1407499:HHUB RS08135
gene id: 1407499:HHUB_RS08135
uniprot id: A0A0U5CYX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1407499:HHUB RS01925
gene id: 1407499:HHUB_RS01925
uniprot id: A0A0U5CVM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

1407499:HHUB RS12975
gene id: 1407499:HHUB_RS12975
uniprot id: A0A0U5H6Q1
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS10860
gene id: 1407499:HHUB_RS10860
uniprot id: A0A0U5D0D2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1407499:HHUB RS02680
gene id: 1407499:HHUB_RS02680
uniprot id: A0A0U5H1V7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

1407499:HHUB RS12725
gene id: 1407499:HHUB_RS12725
uniprot id: A0A0U5H3Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

1407499:HHUB RS04370
gene id: 1407499:HHUB_RS04370
uniprot id: A0A0U5CWX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

1407499:HHUB RS13120
gene id: 1407499:HHUB_RS13120
uniprot id: A0A0U5AJ54
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

1407499:HHUB RS11300
gene id: 1407499:HHUB_RS11300
uniprot id: A0A0U5AI43
names: Function
messages: Part of a potassium transport system.

1407499:HHUB RS10680
gene id: 1407499:HHUB_RS10680
uniprot id: A0A0U5CZZ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS06705
gene id: 1407499:HHUB_RS06705
uniprot id: A0A0U5H2I7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1407499:HHUB RS02950
gene id: 1407499:HHUB_RS02950
uniprot id: A0A0U5ABT2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

1407499:HHUB RS09240
gene id: 1407499:HHUB_RS09240
uniprot id: A0A0U5H312
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

1407499:HHUB RS03890
gene id: 1407499:HHUB_RS03890
uniprot id: A0A0U5HSL7
names: Subcellular Location Annotation
messages: Cell membrane

1407499:HHUB RS13840
gene id: 1407499:HHUB_RS13840
uniprot id: A0A0U5H8D5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

1407499:HHUB RS13075
gene id: 1407499:HHUB_RS13075
uniprot id: A0A0U5D1E1
names: Similarity
messages: Belongs to the beta-eliminating lyase family.

1407499:HHUB RS07540
gene id: 1407499:HHUB_RS07540
uniprot id: A0A0U5H3Q8
names: Similarity
messages: Belongs to the UPF0212 family.

1407499:HHUB RS02835
gene id: 1407499:HHUB_RS02835
uniprot id: A0A0U5H2Y5
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

1407499:HHUB RS14300
gene id: 1407499:HHUB_RS14300
uniprot id: A0A0U5H8P0
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS11500
gene id: 1407499:HHUB_RS11500
uniprot id: A0A0U5H891
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

1407499:HHUB RS02845
gene id: 1407499:HHUB_RS02845
uniprot id: A0A0U5H0X5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

1407499:HHUB RS08535
gene id: 1407499:HHUB_RS08535
uniprot id: A0A0U5CZ37
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

1407499:HHUB RS08450
gene id: 1407499:HHUB_RS08450
uniprot id: A0A0U5H567
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

1407499:HHUB RS05895
gene id: 1407499:HHUB_RS05895
uniprot id: A0A0U5H143
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

1407499:HHUB RS00095
gene id: 1407499:HHUB_RS00095
uniprot id: A0A0U5A9U6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

1407499:HHUB RS13220
gene id: 1407499:HHUB_RS13220
uniprot id: A0A0U5H810
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1407499:HHUB RS07410
gene id: 1407499:HHUB_RS07410
uniprot id: A0A0U5HUJ3
names: Similarity
messages: Belongs to the UPF0111 family.

1407499:HHUB RS11695
gene id: 1407499:HHUB_RS11695
uniprot id: A0A0U5H5X5
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1407499:HHUB RS08740
gene id: 1407499:HHUB_RS08740
uniprot id: A0A0U5HV99
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

1407499:HHUB RS01890
gene id: 1407499:HHUB_RS01890
uniprot id: A0A0U5AB24
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

1407499:HHUB RS06075
gene id: 1407499:HHUB_RS06075
uniprot id: A0A0U5H049
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1407499:HHUB RS05520
gene id: 1407499:HHUB_RS05520
uniprot id: A0A0U5H271
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

1407499:HHUB RS05795
gene id: 1407499:HHUB_RS05795
uniprot id: A0A0U5H2F7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1407499:HHUB RS04985
gene id: 1407499:HHUB_RS04985
uniprot id: A0A0U5H354
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

1407499:HHUB RS01905
gene id: 1407499:HHUB_RS01905
uniprot id: A0A0U5H1G5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

1407499:HHUB RS01140
gene id: 1407499:HHUB_RS01140
uniprot id: A0A0U5CV34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

1407499:HHUB RS12545
gene id: 1407499:HHUB_RS12545
uniprot id: A0A0U5H501
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

1407499:HHUB RS03335
gene id: 1407499:HHUB_RS03335
uniprot id: A0A0U5GYQ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS06310
gene id: 1407499:HHUB_RS06310
uniprot id: A0A0U5H6F2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS10865
gene id: 1407499:HHUB_RS10865
uniprot id: A0A0U5H6H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1407499:HHUB RS06390
gene id: 1407499:HHUB_RS06390
uniprot id: A0A0U5H6G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1407499:HHUB RS10335
gene id: 1407499:HHUB_RS10335
uniprot id: A0A0U5H2G5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1407499:HHUB RS01935
gene id: 1407499:HHUB_RS01935
uniprot id: A0A0U5H2D4
names: Similarity
messages: Belongs to the UPF0175 family.

1407499:HHUB RS05570
gene id: 1407499:HHUB_RS05570
uniprot id: A0A0U5H2L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

1407499:HHUB RS11280
gene id: 1407499:HHUB_RS11280
uniprot id: A0A0U5H339
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS05625
gene id: 1407499:HHUB_RS05625
uniprot id: A0A0U5H4L5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

1407499:HHUB RS09220
gene id: 1407499:HHUB_RS09220
uniprot id: A0A0U5H4G5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

1407499:HHUB RS07385
gene id: 1407499:HHUB_RS07385
uniprot id: A0A0U5H735
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1407499:HHUB RS08410
gene id: 1407499:HHUB_RS08410
uniprot id: A0A0U5H489
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

1407499:HHUB RS05075
gene id: 1407499:HHUB_RS05075
uniprot id: A0A0U5H0M7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS01095
gene id: 1407499:HHUB_RS01095
uniprot id: A0A0U5GXL2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS10265
gene id: 1407499:HHUB_RS10265
uniprot id: A0A0U5H4M4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS04870
gene id: 1407499:HHUB_RS04870
uniprot id: A0A0U5H455
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADH dehydrogenase family.
messages: Cytoplasm

1407499:HHUB RS15640
gene id: 1407499:HHUB_RS15640
uniprot id: A0A0U5H9L7
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS10310
gene id: 1407499:HHUB_RS10310
uniprot id: A0A0U5D018
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

1407499:HHUB RS09980
gene id: 1407499:HHUB_RS09980
uniprot id: A0A0U5HW03
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1407499:HHUB RS06190
gene id: 1407499:HHUB_RS06190
uniprot id: A0A0U5H2P2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

1407499:HHUB RS01275
gene id: 1407499:HHUB_RS01275
uniprot id: A0A0U5GZC5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS09620
gene id: 1407499:HHUB_RS09620
uniprot id: A0A0U5H388
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS03840
gene id: 1407499:HHUB_RS03840
uniprot id: A0A0U5CWN5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

1407499:HHUB RS09175
gene id: 1407499:HHUB_RS09175
uniprot id: A0A0U5H2Z5
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

1407499:HHUB RS10295
gene id: 1407499:HHUB_RS10295
uniprot id: A0A0U5D011
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

1407499:HHUB RS13330
gene id: 1407499:HHUB_RS13330
uniprot id: A0A0U5H9B8
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

1407499:HHUB RS08490
gene id: 1407499:HHUB_RS08490
uniprot id: A0A0U5H4A4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

1407499:HHUB RS03130
gene id: 1407499:HHUB_RS03130
uniprot id: A0A0U5CWI5
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS11460
gene id: 1407499:HHUB_RS11460
uniprot id: A0A0U5AI68
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

1407499:HHUB RS09330
gene id: 1407499:HHUB_RS09330
uniprot id: A0A0U5H5N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1407499:HHUB RS08205
gene id: 1407499:HHUB_RS08205
uniprot id: A0A0U5H526
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1407499:HHUB RS11680
gene id: 1407499:HHUB_RS11680
uniprot id: A0A0U5HWZ3
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

1407499:HHUB RS01385
gene id: 1407499:HHUB_RS01385
uniprot id: A0A0U5CVL1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1407499:HHUB RS04845
gene id: 1407499:HHUB_RS04845
uniprot id: A0A0U5H328
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS05825
gene id: 1407499:HHUB_RS05825
uniprot id: A0A0U5H3Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

1407499:HHUB RS11030
gene id: 1407499:HHUB_RS11030
uniprot id: A0A0U5H9A0
names: Similarity
messages: Belongs to the PdaD family.

1407499:HHUB RS00405
gene id: 1407499:HHUB_RS00405
uniprot id: A0A0U5H1H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1407499:HHUB RS00420
gene id: 1407499:HHUB_RS00420
uniprot id: A0A0U5GX03
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS03075
gene id: 1407499:HHUB_RS03075
uniprot id: A0A0U5H338
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

1407499:HHUB RS02765
gene id: 1407499:HHUB_RS02765
uniprot id: A0A0U5H4A6
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

1407499:HHUB RS03215
gene id: 1407499:HHUB_RS03215
uniprot id: A0A0U5GZL9
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

1407499:HHUB RS12105
gene id: 1407499:HHUB_RS12105
uniprot id: A0A0U5H6I6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1407499:HHUB RS03035
gene id: 1407499:HHUB_RS03035
uniprot id: A0A0U5GZY0
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS01750
gene id: 1407499:HHUB_RS01750
uniprot id: A0A0U5H1A4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1407499:HHUB RS00760
gene id: 1407499:HHUB_RS00760
uniprot id: A0A0U5CUX4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS00720
gene id: 1407499:HHUB_RS00720
uniprot id: A0A0U5GX73
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

1407499:HHUB RS04790
gene id: 1407499:HHUB_RS04790
uniprot id: A0A0U5CXG1
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS03610
gene id: 1407499:HHUB_RS03610
uniprot id: A0A0U5GZV8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS03965
gene id: 1407499:HHUB_RS03965
uniprot id: A0A0U5GZ26
names: Function
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: May catalyze a purine salvage reaction, the substrate is unknown.

1407499:HHUB RS03805
gene id: 1407499:HHUB_RS03805
uniprot id: A0A0U5GYZ9
names: Similarity
messages: Belongs to the peptidase C56 family.

1407499:HHUB RS13420
gene id: 1407499:HHUB_RS13420
uniprot id: A0A0U5H9D3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS06220
gene id: 1407499:HHUB_RS06220
uniprot id: A0A0U5H4X6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

1407499:HHUB RS02555
gene id: 1407499:HHUB_RS02555
uniprot id: A0A0U5H034
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1407499:HHUB RS09165
gene id: 1407499:HHUB_RS09165
uniprot id: A0A0U5CZD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

1407499:HHUB RS04470
gene id: 1407499:HHUB_RS04470
uniprot id: A0A0U5CX69
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

1407499:HHUB RS10805
gene id: 1407499:HHUB_RS10805
uniprot id: A0A0U5H2R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

1407499:HHUB RS12940
gene id: 1407499:HHUB_RS12940
uniprot id: A0A0U5HAD1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

1407499:HHUB RS07655
gene id: 1407499:HHUB_RS07655
uniprot id: A0A0U5H4R2
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

1407499:HHUB RS08375
gene id: 1407499:HHUB_RS08375
uniprot id: A0A0U5H2J4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS05065
gene id: 1407499:HHUB_RS05065
uniprot id: A0A0U5CX86
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

1407499:HHUB RS08415
gene id: 1407499:HHUB_RS08415
uniprot id: A0A0U5H1F3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1407499:HHUB RS07575
gene id: 1407499:HHUB_RS07575
uniprot id: A0A0U5H3G5
names: Similarity
messages: Belongs to the SDO1/SBDS family.

1407499:HHUB RS10085
gene id: 1407499:HHUB_RS10085
uniprot id: A0A0U5CZX7
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS10475
gene id: 1407499:HHUB_RS10475
uniprot id: A0A0U5H7J0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

1407499:HHUB RS10305
gene id: 1407499:HHUB_RS10305
uniprot id: A0A0U5H3N9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

1407499:HHUB RS06070
gene id: 1407499:HHUB_RS06070
uniprot id: A0A0U5H018
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

1407499:HHUB RS12515
gene id: 1407499:HHUB_RS12515
uniprot id: A0A0U5AIS2
names: Similarity
messages: Belongs to the AOR/FOR family.

1407499:HHUB RS15235
gene id: 1407499:HHUB_RS15235
uniprot id: A0A0U5HAK7
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1407499:HHUB RS01075
gene id: 1407499:HHUB_RS01075
uniprot id: A0A0U5H0W5
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS01860
gene id: 1407499:HHUB_RS01860
uniprot id: A0A0U5H3P3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1407499:HHUB RS00990
gene id: 1407499:HHUB_RS00990
uniprot id: A0A0U5H0V0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1407499:HHUB RS00680
gene id: 1407499:HHUB_RS00680
uniprot id: A0A0U5GYM8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

1407499:HHUB RS12420
gene id: 1407499:HHUB_RS12420
uniprot id: A0A0U5H3K2
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

1407499:HHUB RS08220
gene id: 1407499:HHUB_RS08220
uniprot id: A0A0U5CZ06
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

1407499:HHUB RS08250
gene id: 1407499:HHUB_RS08250
uniprot id: A0A0U5H192
names: Similarity
messages: Belongs to the UPF0179 family.

1407499:HHUB RS08145
gene id: 1407499:HHUB_RS08145
uniprot id: A0A0U5CYZ7
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

1407499:HHUB RS15355
gene id: 1407499:HHUB_RS15355
uniprot id: A0A0U5D2Z8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1407499:HHUB RS10235
gene id: 1407499:HHUB_RS10235
uniprot id: A0A0U5H637
names: Function
messages: Part of a potassium transport system.

1407499:HHUB RS02285
gene id: 1407499:HHUB_RS02285
uniprot id: A0A0U5CW54
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

1407499:HHUB RS06030
gene id: 1407499:HHUB_RS06030
uniprot id: A0A0U5CXT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

1407499:HHUB RS11670
gene id: 1407499:HHUB_RS11670
uniprot id: A0A0U5H364
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1407499:HHUB RS15110
gene id: 1407499:HHUB_RS15110
uniprot id: A0A0U5HYZ1
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS02740
gene id: 1407499:HHUB_RS02740
uniprot id: A0A0U5CWB8
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

1407499:HHUB RS13270
gene id: 1407499:HHUB_RS13270
uniprot id: A0A0U5H418
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1407499:HHUB RS11195
gene id: 1407499:HHUB_RS11195
uniprot id: A0A0U5H609
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

1407499:HHUB RS08420
gene id: 1407499:HHUB_RS08420
uniprot id: A0A0U5H1C3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1407499:HHUB RS01870
gene id: 1407499:HHUB_RS01870
uniprot id: A0A0U5GXS4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1407499:HHUB RS02210
gene id: 1407499:HHUB_RS02210
uniprot id: A0A0U5GZ29
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

1407499:HHUB RS10585
gene id: 1407499:HHUB_RS10585
uniprot id: A0A0U5AHJ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

1407499:HHUB RS09010
gene id: 1407499:HHUB_RS09010
uniprot id: A0A0U5H2X3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

1407499:HHUB RS08525
gene id: 1407499:HHUB_RS08525
uniprot id: A0A0U5H422
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.

1407499:HHUB RS03180
gene id: 1407499:HHUB_RS03180
uniprot id: A0A0U5HS69
names: Similarity
messages: Belongs to the complex I subunit 3 family.

1407499:HHUB RS11320
gene id: 1407499:HHUB_RS11320
uniprot id: A0A0U5D0J3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

1407499:HHUB RS01365
gene id: 1407499:HHUB_RS01365
uniprot id: A0A0U5AAP5
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

1407499:HHUB RS00540
gene id: 1407499:HHUB_RS00540
uniprot id: A0A0U5GY53
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monovalent cation. The ion could be potassium.

1407499:HHUB RS07930
gene id: 1407499:HHUB_RS07930
uniprot id: A0A0U5H7E8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

1407499:HHUB RS06475
gene id: 1407499:HHUB_RS06475
uniprot id: A0A0U5H347
names: Similarity
messages: Belongs to the thioesterase PaaI family.

1407499:HHUB RS07565
gene id: 1407499:HHUB_RS07565
uniprot id: A0A0U5AF34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1407499:HHUB RS12525
gene id: 1407499:HHUB_RS12525
uniprot id: A0A0U5H6F5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

1407499:HHUB RS00325
gene id: 1407499:HHUB_RS00325
uniprot id: A0A0U5H1F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1407499:HHUB RS03185
gene id: 1407499:HHUB_RS03185
uniprot id: A0A0U5ABZ2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

1407499:HHUB RS10275
gene id: 1407499:HHUB_RS10275
uniprot id: A0A0U5AH80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

1407499:HHUB RS03810
gene id: 1407499:HHUB_RS03810
uniprot id: A0A0U5H0W4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1407499:HHUB RS12750
gene id: 1407499:HHUB_RS12750
uniprot id: A0A0U5H5M0
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS07265
gene id: 1407499:HHUB_RS07265
uniprot id: A0A0U5H4H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

1407499:HHUB RS04920
gene id: 1407499:HHUB_RS04920
uniprot id: A0A0U5CXB7
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

1407499:HHUB RS06975
gene id: 1407499:HHUB_RS06975
uniprot id: A0A0U5H5E5
names: Subunit
messages: Homotetramer.

1407499:HHUB RS15115
gene id: 1407499:HHUB_RS15115
uniprot id: A0A0U5AKF1
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS07935
gene id: 1407499:HHUB_RS07935
uniprot id: A0A0U5H3Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

1407499:HHUB RS12650
gene id: 1407499:HHUB_RS12650
uniprot id: A0A0U5H3P9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in both the arginine and lysine biosynthetic pathways.

1407499:HHUB RS04690
gene id: 1407499:HHUB_RS04690
uniprot id: A0A0U5CX21
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

1407499:HHUB RS09485
gene id: 1407499:HHUB_RS09485
uniprot id: A0A0U5H8D3
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS10815
gene id: 1407499:HHUB_RS10815
uniprot id: A0A0U5H4Z7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

1407499:HHUB RS15680
gene id: 1407499:HHUB_RS15680
uniprot id: A0A0U5H5P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family. BdbC subfamily.
messages: Membrane

1407499:HHUB RS10330
gene id: 1407499:HHUB_RS10330
uniprot id: A0A0U5H5F5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

1407499:HHUB RS02315
gene id: 1407499:HHUB_RS02315
uniprot id: A0A0U5GY18
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS04990
gene id: 1407499:HHUB_RS04990
uniprot id: A0A0U5CX73
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1407499:HHUB RS12830
gene id: 1407499:HHUB_RS12830
uniprot id: A0A0U5H5M8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

1407499:HHUB RS15940
gene id: 1407499:HHUB_RS15940
uniprot id: A0A0U5H5Q9
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1407499:HHUB RS02795
gene id: 1407499:HHUB_RS02795
uniprot id: A0A0U5ABP8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

1407499:HHUB RS03100
gene id: 1407499:HHUB_RS03100
uniprot id: A0A0U5H0F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

1407499:HHUB RS00615
gene id: 1407499:HHUB_RS00615
uniprot id: A0A0U5CUV1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS04665
gene id: 1407499:HHUB_RS04665
uniprot id: A0A0U5HT00
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

1407499:HHUB RS06290
gene id: 1407499:HHUB_RS06290
uniprot id: A0A0U5H1B6
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS07595
gene id: 1407499:HHUB_RS07595
uniprot id: A0A0U5H238
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1407499:HHUB RS04620
gene id: 1407499:HHUB_RS04620
uniprot id: A0A0U5H0D7
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS03545
gene id: 1407499:HHUB_RS03545
uniprot id: A0A0U5H2I5
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS12925
gene id: 1407499:HHUB_RS12925
uniprot id: A0A0U5D1B4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

1407499:HHUB RS03200
gene id: 1407499:HHUB_RS03200
uniprot id: A0A0U5H275
names: Caution
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS09435
gene id: 1407499:HHUB_RS09435
uniprot id: A0A0U5HVP1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS06415
gene id: 1407499:HHUB_RS06415
uniprot id: A0A0U5HTZ2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

1407499:HHUB RS11685
gene id: 1407499:HHUB_RS11685
uniprot id: A0A0U5AIA9
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS02045
gene id: 1407499:HHUB_RS02045
uniprot id: A0A0U5GZE6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1407499:HHUB RS12860
gene id: 1407499:HHUB_RS12860
uniprot id: A0A0U5D1A6
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 zinc ion.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

1407499:HHUB RS11590
gene id: 1407499:HHUB_RS11590
uniprot id: A0A0U5H681
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

1407499:HHUB RS02350
gene id: 1407499:HHUB_RS02350
uniprot id: A0A0U5H1R1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

1407499:HHUB RS04385
gene id: 1407499:HHUB_RS04385
uniprot id: A0A0U5CX55
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS11665
gene id: 1407499:HHUB_RS11665
uniprot id: A0A0U5H3B6
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1407499:HHUB RS13020
gene id: 1407499:HHUB_RS13020
uniprot id: A0A0U5H3W7
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS03835
gene id: 1407499:HHUB_RS03835
uniprot id: A0A0U5H2H5
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

1407499:HHUB RS01470
gene id: 1407499:HHUB_RS01470
uniprot id: A0A0U5CV88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Homodimer.

1407499:HHUB RS06455
gene id: 1407499:HHUB_RS06455
uniprot id: A0A0U5CY94
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

1407499:HHUB RS03030
gene id: 1407499:HHUB_RS03030
uniprot id: A0A0U5ABV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

1407499:HHUB RS10380
gene id: 1407499:HHUB_RS10380
uniprot id: A0A0U5CZU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

1407499:HHUB RS02115
gene id: 1407499:HHUB_RS02115
uniprot id: A0A0U5H0D3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1407499:HHUB RS07855
gene id: 1407499:HHUB_RS07855
uniprot id: A0A0U5H145
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

1407499:HHUB RS02610
gene id: 1407499:HHUB_RS02610
uniprot id: A0A0U5H2T7
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS07140
gene id: 1407499:HHUB_RS07140
uniprot id: A0A0U5H5H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1407499:HHUB RS00915
gene id: 1407499:HHUB_RS00915
uniprot id: A0A0U5CV72
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1407499:HHUB RS09005
gene id: 1407499:HHUB_RS09005
uniprot id: A0A0U5CZ88
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

1407499:HHUB RS12380
gene id: 1407499:HHUB_RS12380
uniprot id: A0A0U5D0Y2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

1407499:HHUB RS01415
gene id: 1407499:HHUB_RS01415
uniprot id: A0A0U5H027
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS06505
gene id: 1407499:HHUB_RS06505
uniprot id: A0A0U5H1X7
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1407499:HHUB RS08650
gene id: 1407499:HHUB_RS08650
uniprot id: A0A0U5H1K1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

1407499:HHUB RS02785
gene id: 1407499:HHUB_RS02785
uniprot id: A0A0U5H091
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

1407499:HHUB RS03135
gene id: 1407499:HHUB_RS03135
uniprot id: A0A0U5GZK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

1407499:HHUB RS11395
gene id: 1407499:HHUB_RS11395
uniprot id: A0A0U5D0K5
names: Cofactor
messages: Can also use Mn(2+) ion.

1407499:HHUB RS03205
gene id: 1407499:HHUB_RS03205
uniprot id: A0A0U5CWC4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1407499:HHUB RS09625
gene id: 1407499:HHUB_RS09625
uniprot id: A0A0U5CZR2
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1407499:HHUB RS01320
gene id: 1407499:HHUB_RS01320
uniprot id: A0A0U5CVE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

1407499:HHUB RS09335
gene id: 1407499:HHUB_RS09335
uniprot id: A0A0U5H6R9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS13005
gene id: 1407499:HHUB_RS13005
uniprot id: A0A0U5H950
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

1407499:HHUB RS03700
gene id: 1407499:HHUB_RS03700
uniprot id: A0A0U5H2K8
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

1407499:HHUB RS06885
gene id: 1407499:HHUB_RS06885
uniprot id: A0A0U5CYC8
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS04565
gene id: 1407499:HHUB_RS04565
uniprot id: A0A0U5H1Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

1407499:HHUB RS10990
gene id: 1407499:HHUB_RS10990
uniprot id: A0A0U5H5I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

1407499:HHUB RS07550
gene id: 1407499:HHUB_RS07550
uniprot id: A0A0U5H0W3
names: Similarity
messages: Belongs to the acylphosphatase family.

1407499:HHUB RS10625
gene id: 1407499:HHUB_RS10625
uniprot id: A0A0U5H7N0
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

1407499:HHUB RS02625
gene id: 1407499:HHUB_RS02625
uniprot id: A0A0U5GY78
names: Similarity
messages: Belongs to the peptidase S49 family.

1407499:HHUB RS01335
gene id: 1407499:HHUB_RS01335
uniprot id: A0A0U5H3E2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

1407499:HHUB RS07380
gene id: 1407499:HHUB_RS07380
uniprot id: A0A0U5H5M7
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS01135
gene id: 1407499:HHUB_RS01135
uniprot id: A0A0U5H113
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

1407499:HHUB RS09910
gene id: 1407499:HHUB_RS09910
uniprot id: A0A0U5H3X3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

1407499:HHUB RS11940
gene id: 1407499:HHUB_RS11940
uniprot id: A0A0U5H561
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1407499:HHUB RS10150
gene id: 1407499:HHUB_RS10150
uniprot id: A0A0U5H626
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS00635
gene id: 1407499:HHUB_RS00635
uniprot id: A0A0U5H0L8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1407499:HHUB RS06255
gene id: 1407499:HHUB_RS06255
uniprot id: A0A0U5AEB1
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

1407499:HHUB RS05840
gene id: 1407499:HHUB_RS05840
uniprot id: A0A0U5H2S0
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

1407499:HHUB RS02550
gene id: 1407499:HHUB_RS02550
uniprot id: A0A0U5GYA8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS00135
gene id: 1407499:HHUB_RS00135
uniprot id: A0A0U5H0B0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

1407499:HHUB RS12365
gene id: 1407499:HHUB_RS12365
uniprot id: A0A0U5H6C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

1407499:HHUB RS10935
gene id: 1407499:HHUB_RS10935
uniprot id: A0A0U5D0E4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

1407499:HHUB RS13210
gene id: 1407499:HHUB_RS13210
uniprot id: A0A0U5H5V0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS10315
gene id: 1407499:HHUB_RS10315
uniprot id: A0A0U5H653
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

1407499:HHUB RS10355
gene id: 1407499:HHUB_RS10355
uniprot id: A0A0U5AHB2
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1407499:HHUB RS10570
gene id: 1407499:HHUB_RS10570
uniprot id: A0A0U5H2J6
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS09850
gene id: 1407499:HHUB_RS09850
uniprot id: A0A0U5CZK7
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS08400
gene id: 1407499:HHUB_RS08400
uniprot id: A0A0U5H7P7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

1407499:HHUB RS10145
gene id: 1407499:HHUB_RS10145
uniprot id: A0A0U5CZZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

1407499:HHUB RS15070
gene id: 1407499:HHUB_RS15070
uniprot id: A0A0U5D2B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

1407499:HHUB RS09900
gene id: 1407499:HHUB_RS09900
uniprot id: A0A0U5HVX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

1407499:HHUB RS12110
gene id: 1407499:HHUB_RS12110
uniprot id: A0A0U5H3K4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

1407499:HHUB RS07340
gene id: 1407499:HHUB_RS07340
uniprot id: A0A0U5H2C8
names: Similarity
messages: Belongs to the peptidase M24B family.

1407499:HHUB RS02645
gene id: 1407499:HHUB_RS02645
uniprot id: A0A0U5ABK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

1407499:HHUB RS09580
gene id: 1407499:HHUB_RS09580
uniprot id: A0A0U5H491
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.

1407499:HHUB RS12245
gene id: 1407499:HHUB_RS12245
uniprot id: A0A0U5H7D5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

1407499:HHUB RS06775
gene id: 1407499:HHUB_RS06775
uniprot id: A0A0U5H2K2
names: Subcellular Location Annotation
messages: Cell membrane

1407499:HHUB RS12645
gene id: 1407499:HHUB_RS12645
uniprot id: A0A0U5H3W9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS05925
gene id: 1407499:HHUB_RS05925
uniprot id: A0A0U5GZZ6
names: Similarity
messages: Belongs to the UPF0173 family.

1407499:HHUB RS03065
gene id: 1407499:HHUB_RS03065
uniprot id: A0A0U5CWD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

1407499:HHUB RS02685
gene id: 1407499:HHUB_RS02685
uniprot id: A0A0U5H488
names: Similarity
messages: Belongs to the glutamate synthase family.

1407499:HHUB RS02310
gene id: 1407499:HHUB_RS02310
uniprot id: A0A0U5H3Z6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1407499:HHUB RS12500
gene id: 1407499:HHUB_RS12500
uniprot id: A0A0U5H3L8
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

1407499:HHUB RS01690
gene id: 1407499:HHUB_RS01690
uniprot id: A0A0U5GXP7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

1407499:HHUB RS03795
gene id: 1407499:HHUB_RS03795
uniprot id: A0A0U5H1I1
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

1407499:HHUB RS11875
gene id: 1407499:HHUB_RS11875
uniprot id: A0A0U5H797
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

1407499:HHUB RS12575
gene id: 1407499:HHUB_RS12575
uniprot id: A0A0U5H3V3
names: Similarity
messages: Belongs to the threonine aldolase family.

1407499:HHUB RS07805
gene id: 1407499:HHUB_RS07805
uniprot id: A0A0U5H3M0
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

1407499:HHUB RS11575
gene id: 1407499:HHUB_RS11575
uniprot id: A0A0U5H6Z5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

1407499:HHUB RS12310
gene id: 1407499:HHUB_RS12310
uniprot id: A0A0U5D113
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

1407499:HHUB RS00685
gene id: 1407499:HHUB_RS00685
uniprot id: A0A0U5GZJ4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1407499:HHUB RS10730
gene id: 1407499:HHUB_RS10730
uniprot id: A0A0U5H4X8
names: Similarity
messages: Belongs to the Ahb/Nir family.

1407499:HHUB RS10220
gene id: 1407499:HHUB_RS10220
uniprot id: A0A0U5CZR9
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS12025
gene id: 1407499:HHUB_RS12025
uniprot id: A0A0U5H9T8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

1407499:HHUB RS09685
gene id: 1407499:HHUB_RS09685
uniprot id: A0A0U5H5Y3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS11650
gene id: 1407499:HHUB_RS11650
uniprot id: A0A0U5H8C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

1407499:HHUB RS02235
gene id: 1407499:HHUB_RS02235
uniprot id: A0A0U5H0J2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1407499:HHUB RS09500
gene id: 1407499:HHUB_RS09500
uniprot id: A0A0U5H200
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

1407499:HHUB RS04040
gene id: 1407499:HHUB_RS04040
uniprot id: A0A0U5GZ39
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

1407499:HHUB RS12240
gene id: 1407499:HHUB_RS12240
uniprot id: A0A0U5D105
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS06595
gene id: 1407499:HHUB_RS06595
uniprot id: A0A0U5H429
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1407499:HHUB RS11420
gene id: 1407499:HHUB_RS11420
uniprot id: A0A0U5H875
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

1407499:HHUB RS11565
gene id: 1407499:HHUB_RS11565
uniprot id: A0A0U5H4F8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

1407499:HHUB RS15180
gene id: 1407499:HHUB_RS15180
uniprot id: A0A0U5H7T6
names: Similarity
messages: Belongs to the glutaredoxin family.

1407499:HHUB RS12760
gene id: 1407499:HHUB_RS12760
uniprot id: A0A0U5H7S5
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

1407499:HHUB RS04840
gene id: 1407499:HHUB_RS04840
uniprot id: A0A0U5H1V3
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS13215
gene id: 1407499:HHUB_RS13215
uniprot id: A0A0U5H6U8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS09455
gene id: 1407499:HHUB_RS09455
uniprot id: A0A0U5CZM2
names: Similarity
messages: Belongs to the pirin family.

1407499:HHUB RS14930
gene id: 1407499:HHUB_RS14930
uniprot id: A0A0U5D249
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS01130
gene id: 1407499:HHUB_RS01130
uniprot id: A0A0U5GZT7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

1407499:HHUB RS12400
gene id: 1407499:HHUB_RS12400
uniprot id: A0A0U5H8S7
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS08515
gene id: 1407499:HHUB_RS08515
uniprot id: A0A0U5AFN9
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS11560
gene id: 1407499:HHUB_RS11560
uniprot id: A0A0U5D0F6
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS14500
gene id: 1407499:HHUB_RS14500
uniprot id: A0A0U5H7L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

1407499:HHUB RS06845
gene id: 1407499:HHUB_RS06845
uniprot id: A0A0U5H0I2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS12635
gene id: 1407499:HHUB_RS12635
uniprot id: A0A0U5HA67
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

1407499:HHUB RS02945
gene id: 1407499:HHUB_RS02945
uniprot id: A0A0U5HS47
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS06440
gene id: 1407499:HHUB_RS06440
uniprot id: A0A0U5CXZ0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

1407499:HHUB RS03145
gene id: 1407499:HHUB_RS03145
uniprot id: A0A0U5H253
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS13275
gene id: 1407499:HHUB_RS13275
uniprot id: A0A0U5H6H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1407499:HHUB RS06755
gene id: 1407499:HHUB_RS06755
uniprot id: A0A0U5H6P8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

1407499:HHUB RS03165
gene id: 1407499:HHUB_RS03165
uniprot id: A0A0U5GYH7
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS07060
gene id: 1407499:HHUB_RS07060
uniprot id: A0A0U5H5G0
names: Similarity
messages: Belongs to the GARS family.

1407499:HHUB RS03875
gene id: 1407499:HHUB_RS03875
uniprot id: A0A0U5GYV4
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS11660
gene id: 1407499:HHUB_RS11660
uniprot id: A0A0U5H695
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

1407499:HHUB RS10195
gene id: 1407499:HHUB_RS10195
uniprot id: A0A0U5AH67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

1407499:HHUB RS11555
gene id: 1407499:HHUB_RS11555
uniprot id: A0A0U5D0S7
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS07840
gene id: 1407499:HHUB_RS07840
uniprot id: A0A0U5H5V4
names: Similarity
messages: Belongs to the Nth/MutY family.

1407499:HHUB RS12510
gene id: 1407499:HHUB_RS12510
uniprot id: A0A0U5HXE8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

1407499:HHUB RS10230
gene id: 1407499:HHUB_RS10230
uniprot id: A0A0U5D008
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS15700
gene id: 1407499:HHUB_RS15700
uniprot id: A0A0U5AKW0
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS13055
gene id: 1407499:HHUB_RS13055
uniprot id: A0A0U5D1I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

1407499:HHUB RS15160
gene id: 1407499:HHUB_RS15160
uniprot id: A0A0U5HAJ0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

1407499:HHUB RS11610
gene id: 1407499:HHUB_RS11610
uniprot id: A0A0U5H506
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

1407499:HHUB RS09160
gene id: 1407499:HHUB_RS09160
uniprot id: A0A0U5H5L1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1407499:HHUB RS07795
gene id: 1407499:HHUB_RS07795
uniprot id: A0A0U5AF88
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS12660
gene id: 1407499:HHUB_RS12660
uniprot id: A0A0U5HXI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

1407499:HHUB RS11465
gene id: 1407499:HHUB_RS11465
uniprot id: A0A0U5H5T5
names: Similarity
messages: Belongs to the citrate synthase family.

1407499:HHUB RS01355
gene id: 1407499:HHUB_RS01355
uniprot id: A0A0U5GZE3
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

1407499:HHUB RS09135
gene id: 1407499:HHUB_RS09135
uniprot id: A0A0U5H3Z0
names: Similarity
messages: Belongs to the UPF0284 family.

1407499:HHUB RS10600
gene id: 1407499:HHUB_RS10600
uniprot id: A0A0U5H6J5
names: Similarity
messages: Belongs to the SUI1 family.

1407499:HHUB RS00115
gene id: 1407499:HHUB_RS00115
uniprot id: A0A0U5CUN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homodimer.

1407499:HHUB RS01370
gene id: 1407499:HHUB_RS01370
uniprot id: A0A0U5GZ16
names: Similarity
messages: Belongs to the HerA family.

1407499:HHUB RS06670
gene id: 1407499:HHUB_RS06670
uniprot id: A0A0U5CYB4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1407499:HHUB RS12485
gene id: 1407499:HHUB_RS12485
uniprot id: A0A0U5HA35
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

1407499:HHUB RS12765
gene id: 1407499:HHUB_RS12765
uniprot id: A0A0U5D1D0
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

1407499:HHUB RS10365
gene id: 1407499:HHUB_RS10365
uniprot id: A0A0U5H559
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1407499:HHUB RS05020
gene id: 1407499:HHUB_RS05020
uniprot id: A0A0U5H5L2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

1407499:HHUB RS04090
gene id: 1407499:HHUB_RS04090
uniprot id: A0A0U5CX10
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS08660
gene id: 1407499:HHUB_RS08660
uniprot id: A0A0U5H3P4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

1407499:HHUB RS02050
gene id: 1407499:HHUB_RS02050
uniprot id: A0A0U5H1K6
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS02705
gene id: 1407499:HHUB_RS02705
uniprot id: A0A0U5H081
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS04275
gene id: 1407499:HHUB_RS04275
uniprot id: A0A0U5HST3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

1407499:HHUB RS13495
gene id: 1407499:HHUB_RS13495
uniprot id: A0A0U5HAP9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

1407499:HHUB RS09355
gene id: 1407499:HHUB_RS09355
uniprot id: A0A0U5H1W5
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

1407499:HHUB RS09590
gene id: 1407499:HHUB_RS09590
uniprot id: A0A0U5AGE7
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS12335
gene id: 1407499:HHUB_RS12335
uniprot id: A0A0U5H3Q6
names: Similarity
messages: Belongs to the IMPACT family.

1407499:HHUB RS00740
gene id: 1407499:HHUB_RS00740
uniprot id: A0A0U5AA93
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.

1407499:HHUB RS15550
gene id: 1407499:HHUB_RS15550
uniprot id: A0A0U5AKS0
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

1407499:HHUB RS03855
gene id: 1407499:HHUB_RS03855
uniprot id: A0A0U5CWX7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

1407499:HHUB RS01845
gene id: 1407499:HHUB_RS01845
uniprot id: A0A0U5CVL4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

1407499:HHUB RS11295
gene id: 1407499:HHUB_RS11295
uniprot id: A0A0U5HWS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

1407499:HHUB RS01030
gene id: 1407499:HHUB_RS01030
uniprot id: A0A0U5GZ65
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS10930
gene id: 1407499:HHUB_RS10930
uniprot id: A0A0U5H416
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

1407499:HHUB RS10300
gene id: 1407499:HHUB_RS10300
uniprot id: A0A0U5CZT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1407499:HHUB RS12670
gene id: 1407499:HHUB_RS12670
uniprot id: A0A0U5H5K9
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

1407499:HHUB RS02570
gene id: 1407499:HHUB_RS02570
uniprot id: A0A0U5GZP3
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

1407499:HHUB RS12795
gene id: 1407499:HHUB_RS12795
uniprot id: A0A0U5H6X5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

1407499:HHUB RS01050
gene id: 1407499:HHUB_RS01050
uniprot id: A0A0U5GZS2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS07800
gene id: 1407499:HHUB_RS07800
uniprot id: A0A0U5H2N0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

1407499:HHUB RS11925
gene id: 1407499:HHUB_RS11925
uniprot id: A0A0U5H5M6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS08310
gene id: 1407499:HHUB_RS08310
uniprot id: A0A0U5H638
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

1407499:HHUB RS01405
gene id: 1407499:HHUB_RS01405
uniprot id: A0A0U5H246
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1407499:HHUB RS15560
gene id: 1407499:HHUB_RS15560
uniprot id: A0A0U5H877
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS10280
gene id: 1407499:HHUB_RS10280
uniprot id: A0A0U5H463
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1407499:HHUB RS13065
gene id: 1407499:HHUB_RS13065
uniprot id: A0A0U5D190
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

1407499:HHUB RS03900
gene id: 1407499:HHUB_RS03900
uniprot id: A0A0U5H0F0
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

1407499:HHUB RS04055
gene id: 1407499:HHUB_RS04055
uniprot id: A0A0U5ACL3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

1407499:HHUB RS03850
gene id: 1407499:HHUB_RS03850
uniprot id: A0A0U5H002
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

1407499:HHUB RS15520
gene id: 1407499:HHUB_RS15520
uniprot id: A0A0U5H9D7
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS11105
gene id: 1407499:HHUB_RS11105
uniprot id: A0A0U5H7Z1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS00065
gene id: 1407499:HHUB_RS00065
uniprot id: A0A0U5H2L9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

1407499:HHUB RS09020
gene id: 1407499:HHUB_RS09020
uniprot id: A0A0U5H5I5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

1407499:HHUB RS02710
gene id: 1407499:HHUB_RS02710
uniprot id: A0A0U5HS03
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1407499:HHUB RS14350
gene id: 1407499:HHUB_RS14350
uniprot id: A0A0U5H6K9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

1407499:HHUB RS05265
gene id: 1407499:HHUB_RS05265
uniprot id: A0A0U5HTB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

1407499:HHUB RS06930
gene id: 1407499:HHUB_RS06930
uniprot id: A0A0U5HUA1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

1407499:HHUB RS06135
gene id: 1407499:HHUB_RS06135
uniprot id: A0A0U5H4V6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

1407499:HHUB RS11775
gene id: 1407499:HHUB_RS11775
uniprot id: A0A0U5H539
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

1407499:HHUB RS02145
gene id: 1407499:HHUB_RS02145
uniprot id: A0A0U5H1I7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

1407499:HHUB RS15120
gene id: 1407499:HHUB_RS15120
uniprot id: A0A0U5H756
names: Subcellular Location Annotation
messages: Membrane

1407499:HHUB RS12505
gene id: 1407499:HHUB_RS12505
uniprot id: A0A0U5H615
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

1407499:HHUB RS03295
gene id: 1407499:HHUB_RS03295
uniprot id: A0A0U5CWL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

1407499:HHUB RS10240
gene id: 1407499:HHUB_RS10240
uniprot id: A0A0U5H7D6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

1407499:HHUB RS04910
gene id: 1407499:HHUB_RS04910
uniprot id: A0A0U5H1W6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

1407499:HHUB RS12640
gene id: 1407499:HHUB_RS12640
uniprot id: A0A0U5H6U0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS03190
gene id: 1407499:HHUB_RS03190
uniprot id: A0A0U5H011
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1407499:HHUB RS04695
gene id: 1407499:HHUB_RS04695
uniprot id: A0A0U5CX82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

1407499:HHUB RS11755
gene id: 1407499:HHUB_RS11755
uniprot id: A0A0U5H5J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

1407499:HHUB RS11675
gene id: 1407499:HHUB_RS11675
uniprot id: A0A0U5H5H9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

1407499:HHUB RS11230
gene id: 1407499:HHUB_RS11230
uniprot id: A0A0U5H5N7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

1407499:HHUB RS05845
gene id: 1407499:HHUB_RS05845
uniprot id: A0A0U5GZX6
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

1407499:HHUB RS03620
gene id: 1407499:HHUB_RS03620
uniprot id: A0A0U5H2J8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

1407499:HHUB RS11285
gene id: 1407499:HHUB_RS11285
uniprot id: A0A0U5H2Z6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

1407499:HHUB RS10635
gene id: 1407499:HHUB_RS10635
uniprot id: A0A0U5H2N2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.